28
Arch. Environm. Contam. Toxicol. 12, 355-382 (1983) E Archives of nvironrnen1~l c ontamination Springer-Verlag 1983 The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds E. W. Schafer, Jr., W. A. Bowles, Jr., and J. Hurlbut ~ U.S. Fish and Wildlife Service, Wildlife Research Center, Bldg. 16, Denver Federal Center, Denver, Colorado 80225 Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was deter- mined by standardized testing procedures. Red- winged blackbirds were the most sensitive of the bird species tested on a large number of chemicals, and an index based on redwing toxicity and repel- lency may provide an appropriate indication of the probability of acute avian poisoning episodes. Avian repellency and toxicity were not positively correlated (i.e. toxicity varied independently with repellency). In a program designed to evaluate chemicals as potential avian toxicants, stupefacients, or repel- lents, personnel of the Wildlife Research Center at Denver, Colorado have tested (since 1960) over 2000 chemicals for acute oral toxicity to one or more species of wild and domestic birds. The pur- pose of this paper is to summarize the data on 998 known chemicals, draw appropriate generalizations from the data, and make recommendations on how these data might be used to predict acute avian poisoning potential. Methods The chemicals included technical and analytical grade, pestici- dal, pharmaceutical, and other commercial or experimental compounds that were either purchased or solicited from cooperating firms. For presentation purposes, they have been arranged according to Chemical Abstracts Registry Numbers (CAS), and are identified by an accepted trade, coined, product 1 Present address: Department of Chemistry, Metropolitan State College, Auraria Campus, 1006 1lth Street Denver, CO 80204 or other chemical name that is not included in the 9th Collective Index of Chemical Abstracts Service. z Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or sus- pensions of the test chemical in propylene glycol, according to methods described by DeCino et al. (1966), Schafer (1972), and Schafer et al. (1967). Other oral dosing methods were occasion- ally used (pellets, gelatin capsules) but are not noted in the tables (Schafer, 1972). LDs0 values were calculated by the method of Thompson (1948), Thompson and Weil (1952), and Well (1952). Repellency tests were conducted by the methods of Starr et al. (1964) and Schafer and Brunton (1971), and Rs0's (analogous to LDs0's) were calculated either by the method of Litchfield and Wilcoxin (1949) or Thompson and Weft (1952). A repellency-toxicity index (hazard factor) was calculated by assuming that at the Rs0 level, a sixty-five g male redwing would consume 50% of his approximate individual maximum food ca- pacity of 1 g. By making this assumption, it was possible to estimate the mg/kg of a chemical that could conceivably be in- gested by a redwing at a given R~0 level. This value, when divided by the acute oral LDs0, provides an index for indicating how likely it would be for acute oral poisoning to occur in the wild. An index value > 1.00 indicates well-accepted toxic agents that have definite potential for causing acute poisoning episodes, an index value 1>0.25 ~<1.00 indicates these compounds with a possi- ble potential, and an index value <0.25 indicates those compounds with little or no potential to cause acute avian poisoning episodes, at least in redwings. Because of the large amount of data accumulated, an attempt was made to determine the significance of and/or correlation between the two of the measured parameters. Statistical com- parisons of species sensitivities and ranked data were made by Friedmans ranking procedure (Friedman 1937) and ANOVA followed by Duncans Multiple Range Test. Although the non- parametric Friedmans procedure is a more accurate and valid 2 Because of the length and complexity of chemical abstracts nomenclature, the names used to identify chemicals in Table 2 were extracted from several sources. Primary consideration was given to the common name, but shortened chemical names, code numbers, or registered trademarks were also used but may not be specifically identified

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Page 1: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Arch. Environm. Contam. Toxicol. 12, 355-382 (1983) E A r c h i v e s o f

n v i r o n r n e n 1 ~ l

c o n t a m i n a t i o n

�9 Springer-Verlag 1983

The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds

E. W. Schafer, Jr., W. A. Bowles, Jr., and J. Hurlbut ~

U.S. Fish and Wildlife Service, Wildlife Research Center, Bldg. 16, Denver Federal Center, Denver, Colorado 80225

Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was deter- mined by standardized testing procedures. Red- winged blackbirds were the most sensitive of the bird species tested on a large number of chemicals, and an index based on redwing toxicity and repel- lency may provide an appropriate indication of the probability of acute avian poisoning episodes. Avian repellency and toxicity were not positively correlated (i.e. toxicity varied independently with repellency).

In a program designed to evaluate chemicals as potential avian toxicants, stupefacients, or repel- lents, personnel of the Wildlife Research Center at Denver, Colorado have tested (since 1960) over 2000 chemicals for acute oral toxicity to one or more species of wild and domestic birds. The pur- pose of this paper is to summarize the data on 998 known chemicals, draw appropriate generalizations from the data, and make recommendations on how these data might be used to predict acute avian poisoning potential.

Methods

The chemicals included technical and analytical grade, pestici- dal, pharmaceutical, and other commercial or experimental compounds that were either purchased or solicited from cooperating firms. For presentation purposes, they have been arranged according to Chemical Abstracts Registry Numbers (CAS), and are identified by an accepted trade, coined, product

1 Present address: Department of Chemistry, Metropolitan State College, Auraria Campus, 1006 1 lth Street Denver, CO 80204

or other chemical name that is not included in the 9th Collective Index of Chemical Abstracts Service. z

Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or sus- pensions of the test chemical in propylene glycol, according to methods described by DeCino et al. (1966), Schafer (1972), and Schafer et al. (1967). Other oral dosing methods were occasion- ally used (pellets, gelatin capsules) but are not noted in the tables (Schafer, 1972). LDs0 values were calculated by the method of Thompson (1948), Thompson and Weil (1952), and Well (1952). Repellency tests were conducted by the methods of Starr et al.

(1964) and Schafer and Brunton (1971), and Rs0's (analogous to LDs0's) were calculated either by the method of Litchfield and Wilcoxin (1949) or Thompson and Weft (1952).

A repellency-toxicity index (hazard factor) was calculated by assuming that at the Rs0 level, a sixty-five g male redwing would consume 50% of his approximate individual maximum food ca- pacity of 1 g. By making this assumption, it was possible to estimate the mg/kg of a chemical that could conceivably be in- gested by a redwing at a given R~0 level. This value, when divided by the acute oral LDs0, provides an index for indicating how likely it would be for acute oral poisoning to occur in the wild. An index value > 1.00 indicates well-accepted toxic agents that have definite potential for causing acute poisoning episodes, an index value 1>0.25 ~<1.00 indicates these compounds with a possi- ble potential, and an index value <0.25 indicates those compounds with little or no potential to cause acute avian poisoning episodes, at least in redwings.

Because of the large amount of data accumulated, an attempt was made to determine the significance of and/or correlation between the two of the measured parameters. Statistical com- parisons of species sensitivities and ranked data were made by Friedmans ranking procedure (Friedman 1937) and ANOVA followed by Duncans Multiple Range Test. Although the non- parametric Friedmans procedure is a more accurate and valid

2 Because of the length and complexity of chemical abstracts nomenclature, the names used to identify chemicals in Table 2 were extracted from several sources. Primary consideration was given to the common name, but shortened chemical names, code numbers, or registered trademarks were also used but may not be specifically identified

Page 2: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

356 E.W. Schafer, Jr., et al.

method for determining the significance of our data, ANOVA re- sulted in a similar evaluation and allowed us to separate the three most-tested species. In addition, Pearson and Spearman correla- tion coefficients (Snedecor & Cochran 1971) were calculated for redwing R j s and L D j s (when both values were known) to determine possible correlations.

Results

The 68 bird species tested, along with their cur- rently accepted scientific names and a four letter species code that was used in the following tabular data, are detailed in Table 1. Table 2 presents a tabular listing of the acute oral toxicity (LDs0) of the 998 chemicals to one or more of three avian species (redwing, starling, coturnix) plus the avian repel- lency values (Rs0) and the toxicity-repellency index for redwings. Redwing, starling, and coturnix data were analyzed for those cases where L D j s (other than ~< or I> values) were available for all these species (n = 73) or for redwings and starlings along (n = 130). It was shown that redwings were sig- nificantly more sensitive than starlings (p = 0.001), and that starlings and coturnix were not different (p = 0.05). The difference in toxicological sensi- tivity between redwings and starlings was 2. lx and the difference between coturnix and redwings was 1.4x. This agrees with previously published obser- vations of the relative sensitivity relationships of redwings compared to other wild and domestic avian species (Schafer 1972; Schafer et al. 1979).

Statistical comparisons of the correlation be- tween redwing LD~0's and Rs0's were made to de- termine the validity of observations made over the past 20 years indicating that avian repellent activity appears to increase with increasing acute oral tox- icity. Of the 998 chemicals tested, redwing Rs0's and L D j s are presented for 836. Of the 836, Rso and LD~0 values for 501 chemicals (60.0%) were both greater than selected minimum activity levels (1.00% for Rs0 and 100 mg/kg or (90 mg/kg) for LDs0), 84 (10.1%) were repellent at or below 1.00% but toxic above 100 mg/kg, 75 (8.9%) were toxic at or below 100 mg/kg but repellent above 1.00%, 41 (4.9%) were not usable and 135 (16.2%) possessed activity in the range (Rs0 ~<1.00%, LDs0 ~<100

mg/kg) that could be used to examine the relation- ship between these two factors. However, neither Pearson or Spearman correlation coefficients (0.33 and 0.43, respectively) showed any positive corre- lation between Rs0's and LDs0's. Thus, the data in- dicate that gross acute toxicity, as defined by the LDs0, is not positively related to gross repellency, as defined by the R~0, at least over the small range examined.

The repellency/toxicity index or acute avian hazard index was calculated for 377 chemicals where one or both Rs0 and LDso values were known. Those chemicals for which the LDs0 and Rs0 were only known to exceed some value could not be used in subsequent calculations since no meaningful value or trend could be determined by the index. Of the 223 chemicals for which definite index values could be calculated, 124 fell into the > 1.00 class, 47 into the 1>0.25 ~<1.00 class and 52 in the <0.25 class. Examples of some chemicals in the >1.00 class (hazardous) are: Mitomycin C, TEM, thiotepa, famphos, parathion, and dimethoate. Examples of chemicals in the possibly hazardous class (/>0.25 <~ 1.00) are: coumaphos, aprocarb, fen- sulfothion, fenitrothion, and malathion. Examples of chemicals that fall into the probably non- hazardous class (<0.25) are: lidane, sulphenone, chlorpropham, thiram, and chlorothion. This index appears to have great potential for predicting those chemicals that may cause acute avian poisoning episodes in the field. It is the first time, to our knowledge, that an attempt has been made to equate potential hazards to an index that combines the toxicity of a compound with a behavioral mea- sure that predicts how much of the chemical could potentially be consumed in a field situation. Thus, field application of a highly toxic chemical that is aversive to birds could have the same or less likeli- hood of inducing acute avian poisoning as a less toxic chemical that was more readily accepted.

Table 3 presents acute oral toxicity data of 82 chemicals to one or more of seven additional avian species. Table 4 presents the acute oral toxicity and repellency data of 90 chemicals to one or more of 58 other species of birds.

Table 1. Species code, common, and scientific names of birds referred to in this paper

Species code Common name Scientific name

akes American kestrel (Falco sparverius) bbgr Blue-black grassquit (Volatia jacarina) bbmp Black-billed magpie (Pica pica) bhcb Brown-headed cowbird (Molothrus ater) bjay Blue jay (Cyanocitta cristata) brcb Bronzed cowbird (Tangavius aeneus) bowl Barn owl (Tyro alba)

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Chemical Hazards to Birds 357

Table 1. (cont'd)

Species code Common name Scientific name

brth Brown thrasher (Toxostoma rufum) btgr Boat-tailed grackle (Cassidix major) btpa Brown-throated conure (Aratinga pertinax) budg Budgerigar (Melopsittacus undulatus) bwqu Common bobwhite (Cotinus virginianus) bwte Blue-winged teal (Anas discors) cbth Curve-billed thrasher (Toxostoma curvirostre) ccro American crow (Corvus brachyrhynchos) cfin Cassins finch (Carpodacus cassinii) cgoo Canada goose (Branta canadensis) cgra Common grackle (Quiscalus quiscula) chac Plain chachalaca (Ortalis vetula) chaw Cooper's hawk (Accipiter cooperii) cotq Coturnix (Coturnix coturnix) cpig Rock dove or common pigeon (Columba livia) crav Northern raven (Corvus corax) cwax Cedar waxwing (Bombycilla cedrorum) dicl Dickcissel (Spiza americana) edov Eared dove (Zebauda auriculata) gcsp Golden-crowned sparrow (Zonotrichia atricapilla) gdov Common or ground dove (Columbina passerina) geag Golden eagle (Aquila chrysaetos) gosp Golden sparrow (Passer luteus) grja Green jay (Cyanocorax yncas) hfin House finch (Carpodacus mexicanus) hlar Horned lark (Eremophila alpestris) hspa House sparrow (Passer domesticus) idov Inca dove (Scardafella inca) larb Lark bunting (Calamospiza melanocory) maid Mallard (Anas platyrhynchos) mdov Mourning dove (Zenaida macroura) mhaw Northern barrier (Circus cyaneus)

(Marsh hawk) mpar Monk parakeet (Myiopsitta monachus) mwea Northern masked weaver (Ploceus taeniopterus) ofpa Orange-fronted conure (Aratinga canicularis) pind Common pintail (Anas acuta) rbis Red bishop (Euplectes orix) rbgu Ring-billed gull (Larus delawarensis) rbqu Red-billed quelea (Quelea quelea) rbse Ruddy-breasted seedeater (Sporophila minuta) recb Red-eyed cowbird (Tangavius aeneus) rdgo Ruddy ground dove (Columbina talpacoti) rnph Ring-necked pheasant (Phasianus colchicus) robi American robin (Turdus migratorius) rwbb Red-winged blackbird (Agetaius phoeniceus) scrj Scrub jay (Aphelocoma coerulescens) sdov Scaly dove (Scardafella squammata) shcb Shiny cowbird (Molothrus bonariensis) shcr Sandhill crane (Grus canadensis) star European starling (Sturnus vulgaris) swha Swainson's hawk (Buteo swainsoni) tcbb Tricolored blackbird (Agelaius tricolor) turk Wild turkey (Meleagris gallopavo) valq California quail (Loportyx californica) vwea Village weaver (Ploceus cucullatus) wcsp White-crowned sparrow (Zonotrichia leucophrys) wfdo White-fronted dove (Leptotila verreauxi) wwdo White-winged dove (Zenaida asiatica) yhbb Yellow-headed blackbird (Xanthocephalus xanthocephatus) ybmp Yellow-billed magpie (Pica nuttalli)

Page 4: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le

2.

Acu

te

ora

l to

xic

ity

an

d

rep

elle

ncy

o

f 99

8 ch

emic

als

to

Red

win

ged

b

lack

bir

ds,

S

tarl

ing

s,

and

C

otu

rnix

Q

uai

l O

O

Nam

e

Red

win

ged

R

egis

try

L

D~0

bl

ackb

ird

Rs0

n

um

ber

(m

g/kg

) R

so

(mg/

kg)

(CA

S)

(1,2

,5)

(%)(

5)

(3)

Haz

ard

fa

cto

r (4

)

Sta

rlin

g L

D~o

(m

g/kg

)

Co

turn

ix

LD

~0

(mg/

kg)

Phe

noba

rbit

al

Mit

om

yci

n C

H

exob

arbi

tal

sod

ium

M

etha

rbit

al

Ly

serg

ide

Chl

orpr

omaz

ine

Res

erpi

ne

Nic

losa

mid

e A

llox

an

Dac

tiia

omyc

in

Asp

irin

P

iper

onyl

bu

toxi

de

Pro

cain

e H

CI

Tri

eth

yle

nem

elam

ine

2,4-

Din

itro

phen

ol

d-A

mph

etam

ine

SO

4 T

rem

ori

ne

Ure

than

e T

etra

met

hy

lmet

hy

len

edia

min

e T

biot

epa

Cyc

loba

rbit

al

All

obar

bita

l C

yclo

leuc

ine

Bay

373

41

Tri

chlo

rfon

F

amo

ph

os

Hy

dro

xy

dio

ne

sod

ium

N

icot

ine

6-A

zaur

idin

e P

enty

lene

tetr

azol

e 3,

4-D

iam

inop

yrid

ine

gam

ma-

Pic

olin

ic ac

id

Bay

373

42

Fen

thio

n B

usul

fan

Tet

raet

hy

lam

mo

niu

m

chlo

ride

T

ribu

tylt

in o

xide

P

arat

hion

C

ou

map

ho

s C

hlor

obut

anol

S

tryc

hnin

e P

ento

barb

ital

so

diu

m

Mep

rob

amat

e 9,

10-D

imet

hyl-

1,2-

benz

anth

race

ne

Caf

fein

e M

enad

ione

D

ID 4

7 P

erph

enaz

ine

Pro

maz

ine

The

ophy

llin

e L

inda

ne

Bro

mo

deo

xy

uri

din

e &

Chl

oro-

m-c

reso

l

5006

6 +

100(

a,e)

+

1.00

--

50

077

7.50

+

1.00

+

76.9

50

099

+ 10

0(a,

e)

+1.

00

--

5011

3 +

100(

a,e)

+

1.00

--

50

373

1.78

(a,e

) --

--

50

533

--

--

--

5055

5 10

0(a,

e)

--

--

5065

7 +

(60.

0)

0.85

0 65

.4

5071

5 --

1.

70

--

5076

0 1

.00

-3.1

6

+0.

100

+ 7.

69

5078

2 1

00

- +

lO0(

a,e)

+

1.00

+

76.9

51

036

+ 10

0(a)

+

1.00

--

51

058

--

--

5118

3 2

.87

-5.6

2

+1.

00

+76

.9

5128

5 13

.3(a

) --

--

51

638

56.2

0.

121

9.30

51

730

100(

a,e)

+

1.00

+

76.9

51

796

+ 10

0(a)

+

0.10

0 --

51

809

+ 10

0 +

1.00

--

52

244

5.62

0.

805

61.9

52

313

+ 10

0(a,

e)

+1.

00

--

5243

7 +

100-

133(

e)

--

--

5252

8 +

178

+1.

00

--

5260

8 4.

22(a

) 0.

237

18.5

52

686

37

.0-7

5.0

0

.11

0-0

.56

2

43.2

52

857

1.78

(e)

0.13

3 10

.2

5310

1 +

100(

a,e)

+

1.00

--

54

115

17.8

0.

650

50.0

54

251

+ 10

0 +

1.00

--

54

955

+ 10

0 0.

826

63.5

54

966

75.0

+

1.00

+

76.9

55

221

+10

00

+1.

00

--

5537

8 7

.50

-10

.0(a

) 0.

110

8.46

55

389

1.69

-3.5

0(a,

b,c)

0.

060

4.62

55

981

56.2

+

1.00

+

76.9

56

348

--

+ 1.

00

--

5635

9 +

(30.

0)

0.31

6 24

.3

5638

2 2.

37(a

,b,c

,e)

0.13

3 10

.2

5672

4 1.

78-3

.60(

a,b,

c)

0.0

02

-0.0

20

1.

53

5715

8 +

100(

a,e)

+

1.00

--

57

249

--

0.03

0 --

57

330

75. 0

(a.e

) --

--

57

534

--

--

--

5797

6 +

100

+ 1.

00

--

5808

2 31

6 0.

180

13.9

58

275

+ 31

6 +

1.00

--

58

366

23.7

(a)

0.08

9 6.

85

5839

9 31

.6(a

,e)

+ 1.

00

+76

.9

5840

2 --

--

--

58

559

--

0.31

6 --

58

899

75.0

(a)

0.12

1 9.

31

5914

3 +

100

+1.

00

--

5950

7 +

(113

) +

1.00

--

+10

.3

- 1.

09

+ 7.

69

+ 0.

769

+27

.4

0.16

5 +

0.76

9

11.0

4.39

1.

17

5.75

2.81

- 0.

635

+ 1.

03

1.13

2.

73

+ 1.

37

- 0.

810

4.31

0.

864

0.04

4

0.28

9 +

2.43

0.12

4

+ 17

.8

+ 31

.6(a

,e)

+ 7

4.0

-+1

00

(a,e

)

+ 3.

16

+ 10

0(a)

+

10

0-

+95

3(a,

e)

3.6

6-4

.22

4

2.2

-46

.0(a

)

+ 10

0(a,

e)

+ 10

0(a)

17.8

+ 10

0(a,

e)

+ 10

0(a)

43

.0

4.22

(e)

+ 10

0(a,

e)

42.2

+ 10

00

+ 50

0(a)

5.3

0-1

7.8

(a,c

)

5.62

(a,c

,e)

75

.0-3

16

(a,c

)

+ 1

00

- +

665(

a,e)

+

127(

e)

50

0-

+ 50

0(e)

100(

a,e)

+

32

5-

+33

5(a,

e)

100(

a)

+ 1

0.0

-+1

00

(m)

+ 3.

16

100-

133(

g)

+ 31

6(m

) 23

7(f,

m)

+ 1

00

-31

6(m

)

42

.2-3

16

(m)

+ I0

0-

316(

m)

+ 31

6(0

+ t 0

00

17.8

(c)

31

6-

750(

g)

4.22

(c)

13.3

(c)

237(

1")

+ 31

6(0

+ 10

0

Page 5: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

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Hyp

oxan

thin

e F

luph

enaz

ine

Xan

thin

e M

ephe

noxa

lone

p

-Tol

tten

esul

fona

mid

e 4'

-Am

inop

ropi

ophe

none

S

ucci

nylc

holi

ne c

hlor

ide

n-B

utyl

alc

ohol

T

hiop

enta

l so

dium

E

ndri

n M

estr

anol

A

liza

rin

Ade

nine

G

uani

ne

Eth

ylam

ine

Met

hane

sulf

onic

aci

d T

rieh

loro

acet

alde

hyde

T

riph

enyl

tin

hydr

oxid

e G

lute

thim

ide

But

albi

tal

But

etha

l T

omat

idin

e Q

uini

c ac

id

Dio

xath

ion

DE

F

Pro

pion

amid

e A

cryl

ic a

cid

Thi

osem

icar

bazi

de

Isob

utyr

ic a

cid

Met

hacr

ylic

aci

d C

amph

ene

Phe

nagl

ycod

ol

5967

6 59

927

6035

5 60

413

6051

5 60

571

6081

1 60

899

6112

1 61

825

6253

3 62

737

6274

8 63

127

6325

2 64

006

6418

6 64

551

6486

8 65

305

6585

0 66

251

6627

3 66

819

6721

0 67

516

6768

5 68

882

6894

0 69

238

6989

6 70

075

7055

3 70

699

7127

2 71

363

7173

8 72

208

7233

3 72

480

7324

5 73

405

7504

7 75

752

7587

6 76

879

7721

4 77

269

7728

1 77

598

7795

2 78

342

7848

8 7

90

50

79

107

7919

6 79

312

7941

4 79

925

7993

6

+ 10

00

lO0

+ (l

Ol)

6.

00(e

) 6.

60-1

7.8(

a)

17.8

(c)

+ 10

0

42.2

(a,e

) +

100

562 13

.3-1

7.8(

a,c)

4.

22

100(

a,e)

5

6.2

- +

150(

a)

3.16

-10.

0(a,

d,e)

+

(111

) 10

0(a,

e)

- 31

.6

75.0

(a,e

,h)

+ lO

0(a)

56.2

+ 10

0 +

(104

) 1

00

- +

lO0(

a)

+ 10

0-17

8(a,

e)

+ lO

0(a,

e)

75.0

(a)

133

+ 10

0- +

500(

e)

133(

e)

2.37

(a,c

) +

1000

31

6

+ (1

01)

+ 10

0 +

lO0(

a,e)

+

100

+ lO

0(a,

e)

lO0(

a,e)

13

3-17

8(e)

+

100

+ 10

0 +

100

+ (1

01)

+ (9

8.0)

+

(98.

0)

+ (1

01)

+ (1

11)

+ (9

6~0)

31.6

-316

(a,e

)

+ 1.

00

+0.

316

+ 1.

00

O. 1

60-0

.562

+ 1.

00

+1.

oo

+ 1.

oo

+ 1.

OO

0.

488

+1.

00

O. 1

20-0

.210

0.

020

+1.

oo

+1.

00

0.28

4 0.

095 -

0.2

55(h

) +

1.oo

+1.

oo

o.31

6 +

1.oo

+

1.0o

+

1.oo

+3.

16

0.48

6 2.

65

+1.

oo

0.68

0

+1.

0o

+1.

oo

0.08

3 +

1.oo

+

1.0o

2.

55

+2.

50

+1.

oo

+ 1.

o0

+1.

oo

+1.

o0

0.90

0 +

1.oo

+

i.0

0

+1.

oo

+ 1.

oo

+1.

0o

+1.

00

+1.

oo

+ 1.

o0

+1.

o0

+1.

oo

+1.

00

+ 1.

00

+24

.3

43.2

+76

.9

+76

.9

37.5

+76

.9

16.2

1.

54

+76

.9

21.8

19

.6

+76

.9

+ 76

.9

37.4

52.3

+76

.9

6.38

+76

.9

69.2

+

76.9

+

76.9

+ 76

.9

+ 0.

234

6.55

+ 1.

82

+ O

. 137

2.

82

+ 0.

769

0.28

7 0.

481

+ 0.

769

+ 0.

690

0.26

1

+ 1.

37

+ 0.

769

0.21

0

0.69

7

+ 0.

578

2.69

+ 0.

243

- 0.

692

+ 0.

769

+ 0.

769

+ 2.

43

+ 10

00

- 5.

00(a

) 31

.6(a

) 23

7(c)

- 18

3-20

0(e)

lO

0(a)

+ I0

00

11.0

-42.

2(a,

c)

2.37

+

lO0(

a,e)

17.0

(a,d

,e)

+ lO

0(a,

e)

+ lO

0(a,

e)

+ lO

0(a)

1 O

0-

+ lO

0(a)

+

527(

e)

+ lO

0-56

2(a,

e)

+ lO

0(a,

e)

75.0

(a)

316

460(

e)

-25

00

+

lO0(

a,e)

2.

37-3

.16(

a,c,

k)

+ lO

0(a,

e)

+ lO

0(a,

e)

+ lO

0(a,

e)

9. l

o -

11.O

(a)

+ 1

00

- +

577(

e)

+ lO

OO

56.2

(c)

+ 31

6(m

) 75

0 23.7

(c)

42.2

-64.

7(f)

31

6 75.0

(0

+ lo

oo(0

31

6-

+31

6(m

)

4.22

(c)

+ lO

00(g

)

lOO

t(t)

+ lO

O

g~

N

r~

Page 6: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

. (c

on

t'd

)

Nam

e

Su

lph

eno

ne

Dap

son

e D

iaza

ld

CI

3715

1 T

igli

c ac

id

Ch

lorm

ezan

on

e 4-

Am

ino-

l-b

enzo

yla

min

oan

thra

qu

ino

ne

l-A

min

o-2

,4-d

ibro

mo

anth

raq

uin

on

e Q

uini

zari

n 3

,9-D

ibro

mo

ben

zan

thro

ne

Ben

zan

thro

ne

An

thri

mid

e 1 -

Am

ino

-2-m

eth

yla

nth

raq

uin

on

e 1,

5-D

init

roan

thra

quin

one

1 -M

eth

yla

min

oan

thra

qu

ino

ne

1,8-

Dic

hlor

oant

hraq

uino

ne

l-C

hlor

oant

hraq

uino

ne

1-A

min

oan

thra

qu

ino

ne

1,5-

Dic

hlor

oant

hraq

uino

ne

1-A

nthr

aqui

none

sulf

onic

aci

d A

cen

aph

tho

qu

ino

ne

Buc

lizi

ne

Am

py

ron

e A

cen

aph

then

e S

kato

le

l-A

min

o-2

-an

thra

qu

ino

nes

ulf

on

ic a

cid

Th

eob

rom

ine

Ph

enan

thre

neq

uin

on

e 9,

10-A

nthr

aqai

none

-2-s

u/fo

nic

acid

A

nthr

aqui

none

-2,6

-dis

ulfo

nic

acid

2

-Met

hy

lan

thra

qu

ino

ne

An

thra

qu

ino

ne

Met

hy

lmet

han

thra

nil

ate

Ph

enan

thre

ne

2,2

-Ter

eph

thal

oy

l di

benz

oic

acid

M

eth

ylm

eth

anth

ran

ilat

e C

hro

mo

flav

ine

Azi

np

ho

s-m

eth

yl

Flu

ore

ne

3,4

,5-T

rim

eth

ox

yb

enza

ldeh

yd

e E

thy

lan

thra

nil

ate

Vio

luri

c ac

id

6-C

hlor

opur

ine

Pyr

olan

3-

Chl

oro-

o-to

luid

ine

Pyr

ogal

lol

Chl

oran

ilic

aci

d V

inyl

pyrr

olid

one

2-C

arb

ox

yfu

ran

E

x 5

004

An

thra

nil

amid

e 2-

Nit

roan

ilin

e T

IBA

Reg

istr

y

nu

mb

er

(CA

S)

LD

so

(mg/

kg)

(1,2

,5)

Red

win

ged

b

lack

bir

d

Rs0

(%

)(5)

Rso

(m

g/kg

) (3

)

Haz

ard

fa

cto

r (4

)

Sta

rlin

g L

Dso

(m

g/kg

)

8000

2 80

080

8011

5 80

228

8059

1 80

773

8146

9 81

492

8164

1 81

981

8205

3 82

224

8228

0 82

359

8238

2 82

439

8244

0 82

451

8246

2 82

495

8286

0 82

951

8307

8 83

329

8334

1 83

625

8367

0 84

117

8448

0 84

504

8454

8 84

651

8501

6 85

018

8559

6 85

916

8640

8 86

500

8673

7 86

817

8725

2 87

398

8742

3 87

478

8760

5 87

661

8788

7 88

120

8814

2 88

368

8868

6 88

744

8882

4

+

100

+

100

+

mO

O(a

) +

(m

id

+

lOO

(a,e

) +

(m m

3)

+

316

+

(40.

0)

+ (

113)

4

316

+10

00

+

316

+

316

+ (

113)

+

(10

3)

+

lO0(

a,e)

+

m

00(a

) +

(10

1)

+

(98.

0)

+ (9

0.0)

+ (1

04)

+ (

113)

+

(11

3)

+ (

113)

+

1

00

- +

300(

a)

+ (

113)

+

(10

0)

56.2

8

.00

-8.5

0(a

) +

(10

1)

422

+ 10

0 +

m

oo

237 75

.0

+

(96

.0-9

6.3

) +

(9

8.0)

+

(9

8.0)

+

10

0(a,

e)

1000

75

0 +

10

0

0.08

0 +

1.0

0 +

1.0

0 +

l.O

0 +

1.0

0 +

1.00

+

1.00

+

3.1

6

1.65

+

1.4

6 0

.29

0-

+3

.16

0

.20

0-0

.23

0

0.60

0 +

2.6

6

0.60

0 0.

600

0.42

2 +

m.0

0 +

1.00

+

0.10

0 +

1.00

+

m.0

0 +

1.oo

+

1.0

0 +

1.0

0 0.

800

L27

0.

800

+

1.00

+

1.00

0.

800

0.10

0 0.

600

+1

.90

+

l.0

0

+ 1

.00

+ 1

.00

0.61

9 0.

160

+1.

00

+ m

.oo

+1.

oo

+l.

00

+

1.0

0 0.

040

+1.

00

+ 1

.00

0.58

0 -

+ 1

.00

+1.

00

+l.

O0

+ l

.O0

+1.

00

+ 1

.00

+ 1

.00

6.15

127 46

.2

46.2

46

.2

32.3

61.5

61.5

61.5

46

.1

47.6

12

.3

+76

.9

+76

.9

+76

.9

+76

.9

+76

.9

- 0.

062

- 0.

402

- 1.

16

- 0.

409

- 0.

537

- 0.

032

- 0.

683

- 0.

591

- 0.

544

- 0.

154

0. 8

47

1.54

+

0.18

3

+

0.32

5 +

1.

03

+

0.07

7 +

0.

103

+

lO0(

a)

+

lO0(

a,e)

+

lO0(

a,e)

+

m

OO

(a)

27.0

(a)

38.7

(a)

562

+

I00(

a,e)

+

100

0 +

100

0

Co

turn

ix

LD

so

(mg/

kg)

F +

m

00(m

)

+

10

0-3

16

(m)

+ 1

000

750

Page 7: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Din

oseb

2

,4-D

init

rob

enze

ne

sulf

onic

aci

d N

orp

hen

azo

ne

3,5

-Dih

yd

rox

y-2

-nap

hth

oic

aci

d 1,

4-D

imet

hox

y-2-

nit

rob

enze

ne

1,2,

4-T

rich

loro

-5-n

itro

ben

zen

e 2

-Hy

dro

xy

ben

zoh

yd

rox

amic

aci

d (+

)-P

ule

go

ne

Res

acet

op

hen

on

e S

alic

ylal

dehy

de

2-A

min

oani

sole

1-

Nap

htho

l H

ym

ecro

mo

ne

An

thro

oe

3,4

,5-T

rim

eth

ox

yci

nn

amic

aci

d M

ichl

ers

ket

on

e T

olu

ene-

2,6

-dii

socy

anat

e Is

atin

D

iph

eny

l S

copo

leti

n 3

-Hy

dro

xy

-2-n

aph

tho

ic a

cid

Tri

toso

l P

hen

oth

iazi

ne

Qui

nald

ic a

cid

Met

hy

leu

gen

ol

Iso

eug

eno

l m

eth

yle

ther

U

mb

elli

fero

ne

Th

ioq

uin

ox

B

enzo

cain

e T

etra

cain

e B

uta

mb

en

Ch

alco

ne

Saf

role

E

tho

hex

adio

l 5-

Chl

oro-

o-an

isid

ine

Ind

ene

Ben

zoth

iazo

le

o-C

hlor

oani

line

o

-Flu

oro

tolu

ene

o-T

olui

dine

o

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eny

len

edia

min

e o

-Am

ino

ph

eno

l o

-Ch

loro

ph

eno

l 3,

4-X

ylid

ine

4-C

hlor

o-o

-tol

uidi

ne

Met

hy

lhy

dro

qu

ino

ne

3-C

hlor

o-p

-tol

uidi

ne

3,4-

Dic

hlor

oani

line

5-

Chl

oro-

o-to

luid

ine

3-C

hlor

o- 1

,2-p

ropa

nedi

ol

Th

iog

lyce

rol

Bu

tyro

lact

on

e 2

-Am

ino

thia

zole

2-

Nit

ro-p

-ani

sidi

ne

4-C

hlor

o-3-

nitr

oben

zoic

aci

d D

ichl

ofen

thio

n 5-

Chl

oro-

2,4-

dim

etho

xyan

ilin

e E

ug

eno

l Is

oeu

gen

ol

Dis

ulfi

ram

8885

7 89

021

8925

8 89

350

8939

4 89

690

8973

6 89

827

8984

9 90

028

9004

0 90

153

9033

5 90

448

9050

6 90

948

9108

7 91

565

9252

4 92

615

9270

6 92

717

9284

2 93

107

9315

2 93

163

9335

6 93

754

9409

7 94

246

9425

7 94

417

9459

7 94

962

9503

4 95

136

9516

9 95

512

9552

3 95

534

9554

5 95

556

9557

8 95

647

9569

2 95

716

9574

9 95

761

9576

4 96

242

9627

5 96

480

9650

4 96

968

9699

1 97

176

975O

7 97

530

9754

1 97

778

7.50

+

lO

0(a)

+

(9

6.0)

+

10

0 +

lO

0(a)

lO

0(a)

+

lO

0 +

31

6 +

(lo

D

+ (

111)

75

0 +

(to

o)

+

100

+ 0

13

) 42

2 lO

0 10

0 +

(lO

l)

+

(96.

0)

+ 10

o +

(68.

0)

+

(96.

2)

+

lO0(

e)

lO0(

a)

+

316

+

316

+

100

+ (

106)

(a)

56.0

(a)

+

100(

e)

100(

e)

+

100

+

316

+

100

+

lO0(

a)

+ (

lOl)

+

(9

6.0)

+

1

00

- 56

2(a)

+

10

0 +

1

00

-31

6

133

+ 1

000

+ (

113)

5.

62(a

) 75

.0

+ (1

48) 1.0

0-2

.37

(a)

237

+ 1

000 23

.7

+

100

+

100

+

(98.

0)

+

lO0(

a)

75

.0-

lO0(

a)

,14

.0-1

7.8

(a,c

) +

lO

0(a)

+

31

6 +

31

6 +

(11

1)

0.64

8 +

1.0

0 +

1.0

0 +

1.0

0

O. 6

80

+1.

00

0.56

2 +

1.0

0 +

1.0

0 +

1.0

0 +

1.0

0 +

1.0

0 +

1.00

+

1.oo

+

1.0

0

+ 1

.00

+ 1

.oo

+ 1

.00

+ 1

.00

0.42

2 +

1.0

0

+ 1

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+ 1

.00

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.00

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00

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+

1.oo

0.

237

+1.

00

o.31

6 +

1.00

+

1.0

0 +

1.o

o +

l.OO

+

1.0

0 +

1.0

0 +

1.00

+

1.0

0

+ 1

.oo

+ 1

.oo

+ 1

.00

+ 1

.00

0.31

6 +

1.0

0 +

1.0

0

+ 1

.00

+ 1

.00

0.31

6 +

1.0

0

o. 1

70

-0.8

26

0.

680

+ 1

.00

+ 1

.oo,

+

1.0

0

49.8

57.3

+

76.9

43

.2

+76

.9

+7

6.9

+

76.9

32.3

+76

,9

+7

6,9

+7

6.9

18.2

24.6

+76

.9

+7

6.9

+

76.9

+76

.9

+76

.9

+7

6.9

24

.6

+7

6.9

24.6

+

76.9

63

.5

52.3

6.64

- 0.

523

+

0.76

9 -

0.43

2

+

0.10

3

+

0.18

3 +

0.

769

- 0.

475

+

0.76

9

+

1.37

+

0.76

9

- 0.

058

- 0.

246

+ O

. 137

+ O

.243

+

0.

578

+1

3.7

+

1.

03

+7

6.9

O

. 104

+ 3.

25

- 0.

246

+

1.03

3.

57

- 0.

523

7.1

0-8

.30

(a)

+

lO0(

a)

+

lOO

+

lO

0(a)

+

lO

0(a)

+

10

0

+ I

000

+

100

+

lO0(

a)

+ lO

O(a

) +

31

6

+

316(

a)

+

10

0-2

98

(e)

+

100(

a,e)

+

316

+

lO0(

a)

+ 10

00

100

+

lOO

-422

+

100

o +

1o00

lO.O

(a)

+

100 3

.16

-4.2

2(a

,k)

562

+10

00

+

lO0(

a)

+

lO0(

a)

80.0

- 23

70(a

,c)

+

lO0(

a)

+

316

422

+

316(

m)

+ 1

000

+ 1

000

+ 1

000

316 1.

00

31

6-4

22

(g)

3 16

(c)

+

316

~Z

N

c~

Page 8: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

. (c

ont'

d)

Nam

e

Fur

fura

l T

hiop

hene

-2-a

ldeh

yde

Ben

zotr

ichl

orid

e B

enze

ne s

ulfo

nic

acid

4-

test

- But

ylca

tech

ol

Cum

ene

alph

a -M

ethy

lben

zyla

min

e 2-

Pyr

idin

ecar

boxy

lic

acid

3-

Car

boxy

anil

ine

3-N

itro

anil

ine

Cit

razi

nic

acid

D

ichl

oran

5-

Nit

ro-o

-tol

uidi

ne

5-N

itro

-o -a

nisi

dine

m

-Din

itro

benz

ene

Met

hylp

arab

en

Cym

ene

4'-A

min

oace

toph

enon

e 4-

Nit

roan

ilin

e T

MP

D

4-V

inyl

pyri

dine

P

heny

l cy

anid

e B

enzy

l al

coho

l N

icot

inyl

alc

ohol

T

riph

enyl

guan

idin

e D

yren

e C

hlor

prop

ham

4,

4'-M

ethy

lene

dian

ilin

e P

heny

lure

than

e 1,

3-D

iphe

nylg

uani

dine

1-

Am

ino-

2,5-

dim

etho

xybe

nzen

e T

riba

tyla

min

e be

ta -N

itro

styr

ene

Azo

benz

ene

Ace

tani

lide

C

hlor

phen

esin

4-

Pro

pyla

niso

le

Ane

thol

e C

inna

mal

dehy

de

p-T

olun

itri

le

p-A

nisi

dine

4-

Met

hylt

hioa

nili

ne

Met

hyln

reth

ane

beta

-Citr

onel

lol

p-C

reso

l 4-

Thi

ocre

sol

p-C

hlor

oani

line

p-

Chl

orop

heno

l p-

Tol

uidi

ne

p-P

heny

lene

diam

ine

Qui

none

A

crol

ein

But

yric

aci

d

Reg

istr

y L

Dso

nu

mbe

r (m

g/kg

) (C

AS

) (1

,2,5

)

9801

1 98

033

9807

7 98

113

9829

3 98

828

9884

0 98

986

9905

8 99

092

9911

6 99

309

9955

8 99

592

9965

0 99

763

9987

6 99

923

1000

16

1002

21

1004

36

1004

70

1005

16

1005

50

1010

19

1010

53

1012

13

1017

79

1019

95

1020

67

1025

67

1028

29

1029

65

1033

33

1038

44

1042

90

1044

50

1044

61

1045

52

1048

58

1049

49

1049

61

1054

08

1062

29

1064

45

1064

56

1064

78

1064

89

1064

90

1065

03

1065

14

1070

28

1079

26

+ (9

8.0)

+

(101

) +

100

+ lO

0(a)

+

(96.

0)

+ (9

8.0)

+

100

178

75O

13

3(a)

+

(104

) +

lO0

+ 10

0(a)

+

100(

a)

42.2

(a)

+ 31

6 +

100-

237(

a)

75.0

-100

(a)

13.3

10

0 +

tOO

(a)

100(

a)

+ 10

00

+ 10

0(a)

+

100

+ 50

0 +

(148

) +

100

+ lO

0(a)

+

100-

+ l

O0(

a)

+ (1

01)

+ (9

8.0)

+

100(

e)

+ 10

0 +

316

316

+ (9

6.0)

+

100

31

6-

+31

6(a)

17

8-23

7(a)

+

lO0(

a)

+ (9

6.0)

+

(98.

O)

+ (1

13)

56.2

(a)

100

+ 1

0.0

- +

100(

a)

Red

win

ged

blac

kbir

d R

~o

(%)(

5)

Rs0

H

azar

d

Sta

rlin

g (m

g/kg

) fa

ctor

L

Ds0

(3

) (4

) (m

g/kg

)

+1.

00

+1.

00

+1.

00

+ 1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

0.31

6 +

1.00

0.

562

0.42

2 0.

680

0.31

6 +

0.1

00

- +

1.00

+

1.00

0.

540

0.31

6 0.

487

+1.

00

+1.

00

+1.

00

+1.

00

0.56

2 0.

237-

0.52

0 0.

120

+1.

00

+0.

100

0.56

4 +

1.00

+

1.00

0.

900

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+I.

00

+1.

00

+ 1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

m

__

m

+76

.9

+ 0.

432

+76

.9

+ 0.

103

24.6

0.

185

43.2

-

0.43

2 32

.3

- 0.

323

52.3

-

0.52

3 24

.6

0.58

5

41.5

0.

175

24.6

0.

328

37.5

2.

82

+76

.9

+ 0.

769

+7

6.9

+

0.76

9

43.2

-

0.43

2 40

.0

- 0.

400

9.23

-

0.0t

8

43.4

-

0.43

4 +

76.9

+

0.76

9

+76

.9

+ 0.

243

+76

.9

+ 0.

240

+76

.9

+ 0.

324

+76

.9

+ 1.

37

+76

.9

+ 0.

769

75.0

(a)

750

+ 10

00

+ m

00(a

)

+ lO

0(a)

+

lO0(

a)

+ lO

0(a)

+ 1

00

-42

2

+ 10

00(a

) 23

.7

+ lO

0(a)

+

100(

a)

+ 10

00

+ 50

0

+ 10

0

+ lO

0(a)

+ 10

0(e)

+ 31

6

+ 3

16

- +

1000

(a)

+ lO

00(a

) +

lO0(

a)

1000

(a)

42.2

(a)

562

+ 10

.0-+

100(

a)

Cot

urni

x L

D5o

(m

g/kg

)

562

+ 10

00

562

13

3-3

16

10

00

42.2

(m)

+ 10

00

+ 10

00

562

237

237

100

Page 9: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Isop

ropy

lace

tone

S

ucci

nic

anhy

drid

e 2-

Am

ino-

5-m

ethy

lthi

adia

zole

P

yraz

oxon

m

-Cre

sol

m -C

hlor

oani

line

m

-Tol

uidi

ne

m-P

heny

lene

diam

ine

3,5-

Dim

ethy

lphe

nol

gam

ma-

Pic

olin

e P

heno

l T

hiop

heno

I B

-Pic

olin

e 3-

Hyd

roxy

pyri

dine

2-

Met

hylp

yrid

ine

2-C

hlor

opyr

idin

e n-

But

ylam

ine

But

yron

itri

le

Pyr

role

T

etra

hydr

ofur

an

Fu

ran

Thi

ophe

ne

Mal

eic

acid

T

etra

ethy

lene

diam

ine

2-B

utyn

edio

l P

yrid

ine

6-M

ethy

l-5-

hept

ene-

2-on

e T

etra

met

hylp

ropa

nedi

amin

e H

exyl

met

hyl

keto

ne

Hex

ylam

ine

Tet

ram

ethy

lput

resc

ine

1,4-

Bis

(dim

eth

ylam

ino)

-2-b

uty

ne

Oct

yl c

hlor

ide

Oct

ylam

ine

Oct

yl a

lcoh

ol

2-U

ndec

anon

e D

imet

hyld

odec

ylam

ine

Non

ylam

ine

Tri

ethy

lene

tetr

amin

e D

ecan

al

Und

ecan

oic

acid

D

odec

yl c

hlor

ide

Dod

ecyl

alc

ohol

L

etha

ne 3

84

Dod

ecyl

ace

tate

E

thcl

orvy

nol

Chl

orpr

othi

xene

C

hlor

phen

iram

ine

mal

eate

5-

Hyd

roxy

tryp

toph

an

Ap

roca

rb

End

osul

fan

Tha

nite

M

epho

barb

ital

T

albu

tal

2-A

min

o-2-

met

hyl-

1-p

ropa

nol

Chl

orph

oniu

m

Am

beno

nium

chl

orid

e F

ensu

lfot

hion

A

ldic

arb

1-A

min

o-4-

hydr

oxya

nthr

aqui

none

1081

01

1083

05

1083

38

1083

49

1083

94

1084

29

1084

41

1084

52

1086

89

1088

94

1089

52

1089

85

1089

96

1090

02

1090

68

1090

91

1097

39

1097

40

1099

77

1099

99

1100

09

1100

21

1101

67

1101

89

1106

56

1108

61

1109

30

1109

52

1t11

37

1112

62

1115

13

1115

35

1118

53

1118

64

1118

75

1121

29

1121

85

1122

09

1122

43

1123

12

1123

78

1125

27

1125

38

]125

61

1126

63

1131

88

1135

97

1139

28

1140

34

1142

61

1152

97

1153

11

1153

88

1154

46

1156

95

1157

86

1157

97

1159

02

1160

63

1168

58

+ 1o

o +

(96.

0)

+ 10

0

+ (1

13)

133(

a)

242

+ 10

00

+ (1

13)

+ 1

00

-+1

00

0

+ (l

l3)

23.7

(a)

1000

75

0 +

lOO

O

10oo

+ (

1oo)

+

(98.

0)

+ (1

Ol)

+

(1O

l)

+ (9

8.0)

+

(96.

o)-+

(lO

O)

75.0

+

IOO

0 +

(111

) +

100

+ (9

8.0)

+

100

+ 10

0

+ 10

0 +

(1O

l)

+ (9

6.0)

+

(lO

l)

+ (1

11)

+ lO

O

+ 1o

o 42

.2(a

,e)

+ lO

0(a,

e)

75.0

(a,e

) +

100 3.

83(a

,c,d

,e)

+ I0

0 +

178-

+31

6(e)

75

.0(a

,e)

+ (1

02)

+ 10

0 +

100(

a,e)

0.

237-

0.31

6(a,

b,c)

1.

78(c

) +

(77.

0)

+1.

oo

+1.

oo

+1.

00

+1.

oo

+ 1.

o0

o. 8

00

+ 1.

oo

+ 1.

oo

+1.

00

+ 1.

00

+1.

00

+ 1.

00

+1.

00

+ 1.

00

+1.

00

+1.

00

+ 1.

00

+1.

00

+1.

00

+ 1.

00

+1.

oo

+1.

00

+1.

oo

+ 1.

oo

+ 1.

oo

+ 1.

oo

+1.

o0

+1.

00

+1.

00

+1.

00

+1.

00

+1.

o0

+1.

oo

+1.

00

+1.

00

+1.

oo

+1.

00

+1.

00

+0.

316

+1.

00

+1.

oo

+ 1.

00

0.31

6 +

0.31

6 0.

036

0.23

7 +

1.o0

+

1.00

+

1.00

+

1.00

0.

562

+1.

00

0.00

09

0. 6

00

+76

.9

+76

.9

61.5

+76

.9

+76

.9

+76

.9

+76

.9

+76

.9

+76

.0

24.3

2.77

+76

.9

43.2

0.06

9

46.2

h-

+ 0.

578

+ ~

318

- 0.

062

+ 3.

25

+ 0.

077

+ 0.

103

+ 0.

077

+ 1.

03

+ 1.

83

0.32

4

0.72

3

+ 1.

03

- 0.

432

0.29

2

- 0,

600

40.0

+10

00

+10

00

+10

00

+10

00

31.6

-75.

0(a)

+

10oo

+

lO0O

+

100o

+

10oo

+1o

0o

+ 10

o

- 10

0(a)

+ 10

0(a,

e)

]00(

a,e)

13.3

-17.

0(a,

c,d,

e)

35.0

(a)

+ lO

0(a,

e)

+ lO

0(a,

e)

+ 10

0(a,

e)

0.56

2(a,

c)

4.22

(c)

+ 31

6(m

)

422

562

562

422

1000

+

1000

+

1000

+

1000

+ 31

6(m

) +

75.0

(m)

+ 1o

oo

+ 31

6(m

)

+ 31

6(m

) +

316(

m)

42.2

(c)

1.78

(c)

4.22

(c)

N

t,o

Page 10: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

. (c

ont'

d)

4~

Nam

e

Dia

nthr

on

An

thra

rufi

n

1,5-

Dis

ulfo

anth

raqu

inon

e Q

uerc

itin

A

nth

raq

uin

on

e-2

-car

bo

xy

lic

acid

2

-Am

ino

anth

raq

uin

on

e D

ichl

one

Chl

oran

il

Ura

mil

2

-Am

ino

ben

zoic

aci

d 3-

Nit

ro-p

-tol

uidi

ne

Iso

lan

B

enzo

in

An

thra

zen

e 3

-Am

ino

-4-m

eth

ox

yb

enza

nil

ide

Iso

safr

ole

In

do

le

N ,

N '-

Dim

eth

yld

ith

ioo

xa

mid

e C

atec

hin

N

,N '-

Did

odec

yldi

thio

ox

amid

e 2-

Imid

azol

idin

one

Van

illi

c ac

id

Tri

eth

yla

min

e 3-

Am

ino-

4-ch

loro

benz

o tr

iflu

orid

e A

cety

lsul

fani

lyl

chlo

ride

2-

Am

ino-

5-ni

trot

hiaz

ole

Mal

athi

on

Bo

my

l F

enit

roth

ion

Dip

hen

yla

min

e p

-Ch

loro

ph

eno

xy

ace

tic

acid

p

-Am

ino

ph

eno

l S

ucci

nim

ide

Par

ald

ehy

de

Pyr

roli

dine

B

ayta

n

Cap

ryli

c ac

id

1,6-

Hex

aned

iam

ine

Cap

ryli

c al

deh

yd

e D

od

ecy

lam

ine

Car

boni

c an

hy

dri

de

Un

sic

acid

E

NT

175

96

Bu

ton

ate

Ox

eth

azai

ne

1-B

rom

o-2

,2-d

imet

ho

xy

pro

pan

on

e E

thin

amat

e 2,

4-D

imet

hylt

hiaz

ole

Dem

eclo

cycl

ine

1,8

-Dia

min

o-4

,5-d

ihy

dro

xy

anth

raq

uin

on

e 1,

4-D

iam

inoa

nthr

aqui

none

2-

Met

hyl-

1-n

itro

anth

raqu

inon

e 1,

5-D

iam

inoa

nthr

aqui

none

Reg

istr

y

LD

so

nu

mb

er

(mg/

kg)

(CA

S)

(1,2

,5)

1171

02

1171

24

1171

46

1173

95

1177

82

1177

93

1178

06

1187

52

1187

85

1189

23

1193

24

1193

80

1195

39

1201

27

1203

54

1205

81

1207

29

1207

96

1208

09

1208

87

1209

34

1213

46

1214

48

1215

06

1216

08

1216

64

1217

55

1221

01

1221

45

1223

94

1228

83

1233

08

1235

68

1236

37

1237

51

1238

86

1240

72

1240

94

1241

30

1242

21

1243

89

1254

62

1261

58

1262

27

1262

72

1263

85

1265

23

1268

18

1273

33

1289

49

1289

50

1291

57

1294

42

+

316

+ (

113)

+

(11

3)

+

100

+ (

113)

+

31

6 +

31

6 +

(10

0)

+

100

750 3.

16(a

)

+

(98.

0)

+ (

111)

+

10

0(a)

+

100

0 +

(10

0)

7.5

0-1

0.0

+

10

0 +

(10

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Page 11: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Car

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Page 12: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

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Page 13: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Inda

n A

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an

3,5-

Dia

min

o be

nzoi

c ac

id

p-D

imet

hyla

min

obey

al r

hoda

nine

4-

Eth

ylpy

ridi

ne

3-A

min

oani

sole

D

iper

odon

4-

lodo

anil

ine

n-B

utyr

amid

e T

rich

loro

acet

onit

rile

D

rope

rido

l Z

olam

ine

Gly

cery

l io

dide

2,

2' ,2

"-T

rich

loro

trie

t hyl

amin

e E

thio

n 2-

Eth

ylan

ilin

e P

otas

sium

car

bona

te

4-A

min

o- 1

,2,4

-tri

azol

e T

olue

ne-2

,4-d

iis o

cyan

ate

n- B

utyl

oxam

ate

4-P

yrid

ylca

rbin

ol

2-py

ridy

lcar

bino

l 3-

Eth

ylan

ilir

te

4-E

thyl

anil

ine

Hyd

roxy

uret

hane

A

cety

lthi

oure

a 3-

Am

inop

heno

l B

utyl

car

bam

ate

Dib

utyl

sul

fone

al

pha-

Met

hyl-

n-bu

tyri

c ac

id

Tri

phen

ylar

sine

T

riph

enyl

bism

uth

Dip

heny

lure

than

e O

xaze

pam

2,

4-D

init

roph

enet

ole

2-C

hlor

o-p-

tolu

idin

e 6-

Chl

oro-

m-c

reso

l

4961

17

4991

27

5002

21

5002

87

5018

26

5033

00

5042

45

5042

90

5101

56

5125

61

5134

95

5188

21

5202

63

5203

65

5238

08

5238

75

5244

03

5244

25

5252

68

5258

26

5277

20

5284

83

5293

40

5320

36

5342

25

5358

75

5361

74

5367

54

536903

5371

22

5403

74

5413

55

545062

5487

32

5531

39

5541

09

555771

5631

22

578541

5840

87

5841

34

5848

49

5852

84

5869

58

5869

81

5870

20

5891

62

5894

13

5910

82

5912

75

5923

58

5980

49

6000

77

6033

27

6033

38

6035

21

6047

51

6105

48

6156

56

6157

47

+ (1

01)

+ (I

00)

+ 10

O0

+ 28

0(a)

+

lO0(

a)

+ I0

0 1.78

-8.5

0(a,

b,c,

*)

31.6

+

10O

+

100

+ (9

6.0)

+

10O

+

100

+ 10

0 +

10

0-+

31

6

+ 42

.2

75.0

+

10o(

a)

+ 10

O

+ (9

6.0)

+

100

+ (1

13)

+ 10

0(a,

e)

+ (9

8.0)

+

100(

a)

+ 10

0(a)

+

10O

56

2 +

1 0o(

a,e)

10

o(a)

+

(96.

0)

+ 10

0 +

100(

a,e)

+

10o(

a,e)

+

100 3L

6

45

.0-

58.I

Ra)

75

0 I0

0 +

100

100

422

75O

31

6 75.0

+

(98.

0)

+ (9

6.0)

23

7 +

100(

a,e)

(111

) +

(98.

0)

+ (9

8.0)

+

lOO

(a)

+ 1

0o

- 17

8(a,

e)

+ 31

.6

562

+1.

0O

+1.

00

+1.

0O

0.3

91

-0,5

62

+

1.0O

+

1.00

0

.04

0-0

.05

3

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

00

+1.

0O

+1.

00

+I.

00

0.355

+1.

00

0.90

8 +

1.00

+

1.00

+

1.00

+

1.00

+1

.0O

+1.

00

0.31

6 +

1.00

0.

562

+1.

00

0.42

2 +

1.00

+

1.00

1.

00

0.42

2 +

1.0O

-0

.17

8

0.31

6 +

1.0O

+

1.00

+

1.00

+1.

0O

+1.

00

+ 1.

00

+1.

0O

+1.

0O

+1.

00

+ 1.

00

0.26

1 +

1.00

+

1.00

+

1,0O

+

1.00

+

1.00

+

1.0O

+

1.00

+

1.0O

+

1.00

+

1.0O

43.2

4.07

+

76.9

27.3

69.8

24.6

43.2

32.3

76.9

32

.5

~---

13.7

24

.3

+76

.9

+76

.9

+76

.9

+76

.9

+76

.9

+76

.9

20.1

+ 76

.9

+76

.9

m -

0.15

4

2.29

+

2.43

0.36

4

- 0.

698

- 0.

246

0.07

7

+ 0.

323

- 0.

769

- 0.

325

- 0.

434

0.54

0 +

0.10

3 +

0.76

9

+ 0.

182

+ 0.

103

+ 0.

243

+ 1.

03

0.08

5

+ 0.

432

+ 0.

137

+1o

00

+ 50

0(a)

+

10o(

a)

4.90

(a,c

,e,l

)

75

.0-1

00

+ 10

0

+ 5

0-

+62

5(e)

+ 10

o(a)

+ 10

o(a,

e)

+ 10

o(a)

+

10o(

a)

+10

O0

+ 10

o(a,

e)

+ 10

o(a)

+ 10

o(a,

e)

+ 10

o(a,

e)

+ 30

4(a)

+

10O

0

+ 10

0

+10

O0

+ 10

00

+ 10

O0

750

+10

O0

+ 10

0(a,

e)

+ lO

0(a)

+

lO0(

a,e)

750

+ 10

4)0 7.

65-8

.05(

c,1)

13

3

86o(

f)

+ 31

6

562

117-

133(

f)

+ lO

OO

+ 31

6(m

)

+10

oo

lOO

0 75

0 42

2

750

562

ta~

Page 14: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

. (c

on

t'd

)

Nam

e

3-A

min

o- 1

,2-p

ropa

nedi

ol

2-P

yrro

lido

ne

2-F

urfu

ryla

min

e N

- Ace

tylp

iper

idin

e p-

Nit

rodi

phen

yl e

ther

1,

3,5-

Tri

met

hoxy

benz

ene

4-C

hlor

oben

zoni

tril

e 3-

Dim

etby

lam

ino-

1,2

-pro

pane

diol

N

-Eth

ylur

etha

ne

3-Io

doan

ilin

e 3-

Chl

orop

yrid

ine

4-C

hlor

opyr

idin

e 4-

Hyd

roxy

pyri

dine

P

ropy

l ca

rbam

ate

Hex

yl c

yani

de

Nap

htho

cain

e H

exad

ecyl

ace

tate

C

arbo

n m

onox

ide

Met

hyls

yrin

gol

4-C

hlor

o- 3-

nitr

oani

line

T

rim

etoz

ine

Dis

tam

ycin

A

3-P

yrid

ylsu

lfon

ic a

cid

Con

iine

HB

r T

rich

loro

cyan

uric

aci

d T

riph

enyl

tin

chl

orid

e F

luor

oace

tam

ide

1,3,

5-T

rim

etho

xyph

enol

D

imet

ilan

H

exam

ethy

lmel

amin

e A

min

ooxy

ace

tic

acid

C

arba

nola

te

U

1755

6 R

E 5

305

Hem

pa

Pyr

idin

e 1-

oxid

e N

-Met

hyl-

2-py

rido

ne

4-P

yrid

inea

ldox

ime

2-(2

-Nit

rovi

nyl)

fura

n T

etra

met

hyl-

1,2

-ben

zene

diam

ine

Pri

loca

ine

Pho

smet

E

PT

C

Dod

ecyl

thi

ocya

nate

A

dam

anta

min

e C

arbo

phen

othi

on

Cal

cium

cit

rate

C

upri

c ox

alat

e D

imet

hoxa

ne

Mes

cali

ne H

CI

Sud

an I

N

apht

hol

Yel

low

S

Lev

opro

maz

ine

Reg

istr

y L

Dso

n

um

ber

(m

g/kg

) (C

AS

) (1

,2,5

)

6163

08

6164

55

6178

90

6184

28

6208

82

6212

38

6230

30

6235

74

6237

89

6260

17

6266

08

6266

19

6266

42

6271

23

6290

83

6295

05

6297

09

6300

80

6343

66

6352

23

6354

16

6364

75

6367

37

6374

90

6381

64

6395

87

6401

97

6427

17

6446

44

6450

56

6458

85

6710

45

6720

60

6731

98

6803

19

6945

97

6948

59

6965

48

6991

83

7040

18

7215

06

7321

16

7599

44

7651

51

7689

45

7861

96

8139

45

8149

15

8280

02

8329

28

8420

79

8467

08

8516

83

+ 10

0 +

(98.

0)

+ (9

6.0)

+

(96.

0)

+ (l

OO

) +

1000

+ i0

0 +

100(

a)

+ 10

0(a)

10

00

+ 10

0 +

10

0-+

10

00

+

100

+ 10

0 13

34(6

) +

lO00

lO

0(a)

+

100(

a,e)

-

(72.

0)

+ 10

0 56.2

+

100 5.

62

+ 10

o0 2.3

7-

6.00

(a,c

,*)

13.3

(d,e

,h)

4.0

0-

5.00

(a,d

,e)

+ 10

0 10

00

+ 10

0 +

100

+ lO

0(a,

e)

17.8

(a)

100(

a)

+ 10

0(a)

+

178 7.

50(a

) +

(lO

O)

+ (1

11)

+ (9

8.0)

+

100

+ 5O

0

lO0(

a,e)

Red

win

ged

blac

kbir

d R

so

Haz

ard

S

tarl

ing

Rs0

(m

g/kg

) fa

ctor

L

Dzo

(%

)(5)

(3

) (4

) (m

g/kg

)

+ 1.

00

+ 1.

00

+ 1.

00

+ 1.

00

+ 1.

00

+1.

00

+1.

00

+ 1.

00

+0.

100

+1.

00

+1.

00

+ 1.

00

+ 1.

00

+ 1.

00

+1.

00

+ 1.

00

+1.

00

o.31

6 +

1.00

0.

422

+ 1.

00

+ 1.

00

+ 1.

00

0.42

2 +

1.00

+

1.00

0.

800

+1.

00

0.09

1 0.

030

+ 1.

00

+1.

00

+ 1.

00

+ 1.

00

+1.

00

0.24

4 +

l.0

0

+ 1.

00

0.28

2 +

1.00

1

.00

-1.1

0

+ 1.

00

+0.

316

+ 1.

00

+1.

00

0.65

0

+76

.9

24.6

32.3

+76

.9

+76

.9

70.0

2.

31

+76

.9

18.8

+

76.9

21.7

84.6

50.0

w m m m

+ 0.

077

0.24

6

+ 0.

449

+ 0.

137

+13

.7

5.26

0.

502

+ 0.

077

1.05

+

0.76

9

2.89

- 0.

762

0.50

0

m m m

+ lO

0(a)

+

lO0(

a)

1000

+ 10

00

+ 10

0

2213

(6)

+ lO

0(a)

+

lO0(

a,e)

250(

a)

11.5

(a,c

,d,e

) +

100(

d,e)

5.

00-6

.00(

a,d)

+ 10

00

+ 10

0(a,

e)

+ 10

0(a)

+

lO0(

a)

+ lO

0(a)

5.62

(a)

+ lO

0(a,

e)

Cot

urni

x L

Ds0

(m

g/kg

)

m m m

750

+ 10

0(m

) +

1000

2103

(6)

+ 31

6(m

) +

56.2

(m)

13.3

(13

316(

13

7.50

(c)

100o

(0

+ 10

00

422(

13

+ 31

6(m

)

+ 1

00

- +

316(

m)

r

~r

Page 15: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Eth

ylen

egly

col

met

hacr

ylat

e D

ieth

ylam

inoe

thyl

chl

orid

e H

CI

4-P

yrid

inec

arbo

xald

ehyd

e 4-

Cya

noan

ilin

e C

hlor

phen

esin

car

bam

ate

Tri

cain

e F

enti

n ac

etat

e Is

opro

pylm

etha

nesu

lfon

ate

2-M

ethy

lpyr

idin

e-N

- oxi

de

Aza

cyto

sine

F

onof

os

Phe

nyls

ulfo

xide

P

hosp

hola

n M

ethy

ltri

thio

n P

henc

ycli

dine

HC

1 T

etra

chlo

rvin

phos

D

inob

uton

N

orbo

rmid

e V

C 3

-676

T

ribu

tylp

hosp

hine

4-

Met

hylp

yrid

ine

1-ox

ide

3-M

ethy

lpyr

idin

e 1-

oxid

e 2,

4,6-

Tri

amin

opyr

imid

ine

3-(2

-Pyr

idyl

)-5,

6-di

phen

yltr

iazi

ne

Tri

met

hylt

in c

hlor

ide

Tri

prop

ylti

n ox

ide

Ace

thyd

razi

de

l-(2

-Cya

noet

hyl)

azir

idin

e D

imer

capt

othi

adia

zole

4-

Hyd

roxy

coum

arin

M

obam

D

ichl

oflu

anid

P

ebul

ate

Lau

ryl

amid

e 3-

Am

ino-

1,2,

4-tr

iazi

ne

3-N

itro

isox

azol

ine

Pyr

ithi

one

Pic

olin

al

4-A

cety

lpyr

idin

e 4-

Dim

ethy

lam

inop

yrid

ine

2-A

cety

lpyr

idin

e P

heny

lfin

tri

chlo

ride

M

OP

S

Ro-

neet

F

erul

ic a

cid

CA

PS

4-

Am

inob

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phen

one

SU

874

6 M

etos

erpa

te H

C1

4-A

min

othi

ophe

nol

Fen

chon

e 4-

Am

inop

heny

l ac

etic

aci

d B

isfp

-nit

roph

enyl

) sul

fide

E

upro

cin

Cal

cium

hyd

roxi

de

Ant

imon

y tr

ioxi

de

Lea

d te

trox

ide

Zin

c ph

osph

ide

Mon

aste

ral

Gre

en

8687

79

8692

49

8728

55

8737

45

8867

48

8868

62

9009

58

9260

67

9311

91

9318

62

9442

29

9455

17

9470

24

9531

73

9569

01

9611

15

9732

17

9914

24

9960

43

9984

03

1003

674

1003

732

1004

382

1046

566

1066

451

1067

294

1068

571

1072

668

1072

715

1076

386

1079

330

1085

989

1114

712

1120

167

1120

996

1121

148

1121

308

1121

604

1122

549

1122

583

1122

629

1124

192

1132

612

1134

232

1135

246

1135

406

1137

413

1142

843

1178

296

1193

028

1195

795

1197

553

1223

310

1301

424

1305

620

1309

644

1314

416

1314

847

1328

536

+ (9

8.0)

42

.2(a

) +

lOO

O

23.7

+

100(

a,e)

+

lO0(

a,e)

10

0 56

2 +

lOO

-+10

00

+ 10

0 lO.O

(a,c

) +

lO0(

a)

2.37

(b,c

) 17

.8(a

) 42

.2(a

,e)

100

+ lO

0(a)

+ (9

8.0)

10

00

+ 10

00

+ 10

0 +

178

+ (9

8.0)

+

(40.

0)

42.2

+ 17

8 +

100 17

.8(c

) +

100(

a)

+ lO

0(a)

+

(96.

0)

+ 10

0 +

(96.

0)

100

+ 10

0 +

10

0-7

50

+

100

1000

+

(98.

0)

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0 +

100(

a)

+ 10

0 +

100

562

+ 10

0 10

0 42.2

+

316

+ 31

6 +

(102

) +

100(

a,e)

+

(111

)

+ (1

11)

23

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237

+ (1

11)

+ 1.

00

0.56

2 +

1.00

0.

316

+ 1.

00

+ 1.

00

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00

+ 1.

00

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00

+ 1.

00

0.23

8 0

.42

2-0

.75

0

O. 1

28

0.13

0 0.

395

+ 1.

00

0.65

0 +

1.00

0.

050

+ 1.

00

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oo

+ 1.

00

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00

0.82

6 +

1.oo

0.

316

+1.

00

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00

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00

o.11

2 +

1.oo

+

1.00

+

1.00

+

1.00

0.

422

+1.

00

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00

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00

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00

+ 1.

0o

+1.

00

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00

+ 1.

00

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00

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00

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00

0.15

3 +

1.00

+

1.00

+

1.00

+

1.00

0.

562

+ 1.

00

+ 1.

00

+ 1.

00

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00

43.1

24.3

+76

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+76

.9

18.3

57

,7

9.84

10

.0

30.4

+

76.9

+76

.9

63.5

24.6

+

76.9

8.61

32.3

+

76.9

+76

.9

+76

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11.8

+

76.9

43.2

1.02

1.03

+ 0.

769

+ 0.

137

1.83

- 0.

577

4.15

0.

562

0.72

2 +

0.76

9

+ 0.

077

- 0.

357

- 0.

615

+ 1.

83

0.48

4

- 0.

337

+ 0.

769

+ o.

103

+ 0.

077

0.11

8 +

1.83

- 0.

432

100(

a)

+ 10

00

316

+ lO

0(a,

e)

+ lO

0(a,

e)

287

+10

00

42.2

(a,c

) +

100 5.

62(c

) +

78

.0-+

17

8(a

) 23

7(a,

e)

+ 10

0

+ lO

0(a)

1000

+

1 000

750(

c)

+ lO

0(a)

+

lO0(

a)

+ 1 0

00

+ 10

00

+ lO

0(a)

+ 56

2 +

100

100 56

.2

+ 31

6

+ 10

0(a,

e)

w +

1000

23

.7

100-

117(

0 5

62

- +

lO00

(g)

+ lO

00(0

+

1oo 31

.6(e

)

23.7

(c)

75O

+

1000

+ 31

6(m

)

5.62

(m)

+ 31

6(m

)

42.2

(c)

+ 1

00

- +

316(

m)

133-

178(

f)

+ 10

00

+ 10

00

+ 31

6(m

)

+ 31

6(m

) +

316 42

.2

8'

~Z

N

r~

Page 16: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

, (c

on

t'd

)

Nam

e

Tri

brom

oeth

anol

C

upro

us o

xide

T

anni

n B

acit

raci

n H

umic

aci

d N

iclo

sam

ide

Am

idep

hrin

e m

esyl

ate

Gua

nazo

le

Tri

buty

l ti

n ch

lori

de

Naf

talo

fos

Tri

fluo

ro m

etha

nesu

lfon

ic a

cid

Eth

ylcy

cloh

exan

e ca

rbam

ate

Gal

locy

anin

e C

arbo

fura

n D

amin

azid

e M

etax

alon

e 1-

(4-E

thox

yphe

nyl)

etha

none

4-A

min

obut

yrop

heno

ne

Nel

lite

A

kton

1,

2-D

iam

inoa

nthr

aqui

none

3-

(Met

hylt

hio)

anil

ine

2-C

yano

anil

ine

2,4,

6-T

riph

enox

y-s-

tria

zine

V

erno

late

N

-Ser

ve

AC

240

55

Phe

nyl

N- m

ethy

lcar

bam

ate

4-A

min

o-3-

pico

line

B

utyl

ate

Am

inoc

arb

Met

hioc

arb

2-A

min

o-4-

mor

phol

ino-

s- tr

iazi

ne

Bis

(4-c

hlor

o-2-

nitr

ophe

nyl)

disu

lfid

e T

rifl

uper

idol

HC

1 B

enpe

rido

l 1 -

Chl

oro-

2,5-

dim

etho

xybe

nzen

e E

PN

4-

Ben

zylp

yrid

ine

Pem

olin

e M

ethi

ocar

b su

lfon

e 1-

Phe

nylc

yclo

hexy

lam

ine

Dow

co 1

59

Eth

yl N

,N-d

ibut

ylca

rbam

ic a

cid

3-C

yano

anil

ine

Fen

cam

fam

in

d- P

hell

andr

ene

Phe

neth

yl i

soth

iocy

anat

e O

lin

5313

9 D

owco

177

P

henc

apto

u T

ripr

opyl

tin

chlo

ride

O

mit

e

Reg

istr

y L

Dso

nu

mbe

r (m

g/kg

) (C

AS

) (1

,2,5

)

1329

868

1371

391

1401

554

1405

874

1415

936

1420

048

1421

687

1455

772

1461

229

1491

414

1493

136

1541

191

1562

852

1563

662

1596

845

1665

481

1676

637

1688

717

1754

581

1757

182

1758

685

1783

819

1885

296

1919

488

1929

777

1929

824

1933

502

1943

799

1990

905

2008

415

2032

599

2032

657

2045

252

2050

660

2062

773

2062

842

2100

427

2104

645

2116

656

2152

343

2179

251

2201

243

2213

845

2217

881

2237

301

2240

144

2243

336

2257

092

2271

934

2274

911

2275

141

2279

767

2312

358

316

+ (5

0.0)

+

100

+ 10

0 +

(101

) +

(96.

0)

+ 10

0 +

100 75

.0-

+ 10

0(a)

1.

78-2

.37(

a)

+ 10

0 +

100

+ 10

0 0.42

2(b,

c)

+ 10

0 +

100(

a,e)

+

(96.

0)

42.2

13

.3(a

,e)

75.0

+

(113

) 75

0 +

1000

+

178

+ 10

0(a)

56.2

(a,e

) +

100(

a,d,

e)

2.37

(a)

+ 10

0(a)

50

.0(a

,d,e

) 4.

67-1

2.6(

a,b,

*)

+ 10

0 +

(96.

0)

133(

e)

+ 10

0(a,

e)

+ 10

0 (a)

3.

16(a

,c,e

) +

17.8

(a)

100(

a,e)

42

.2-1

47(a

) +

(98.

0)

+ 56

.2(a

,e)

+ 10

0(a)

56

2 +

100(

a,e)

+ 10

0

100(

a)

+ 17

8(a)

+

(79.

0)

+ 10

0

Red

win

ged

blac

kbir

d R

s0

(%)(

5)

Rs0

(m

g/kg

) (3

)

Haz

ard

fa

ctor

(4

)

Sta

rlin

g L

Dso

(m

g/kg

)

0.66

0 +

1.00

+

1.00

+

1.00

+

1.00

+

1.00

+

1.00

0.

520

0.02

0 +

1.00

+

1.00

+

1.oo

0.

028

+1.

00

+1.

oo

+1.

o0

+1.

00

0.75

0 +

1.00

0.

650

+ 1.

00

+1.

00

+ 1.

oo

+ 1.

00

+1.

00

+1.

00

0.48

6 +

1.00

o.

150

0.

050-

0.08

9(h)

+

1.00

+

1.00

0.

178

0.56

2 +

1.00

0.

464

0.80

0 +

1.00

0.

562

+1.

00

0.80

0 +

0.10

0 0.

355

+1.

00

1.78

0.

750

+ 1.

00

0.42

2 0.

316

0.80

0 +

1.00

50.8

40.0

1.

54

2.15

+76

.9

57.7

50.0

+76

.9

37.4

11.5

6.

85

13.7

43

.2

35.7

61

.5

+76

.9

43.2

61.5

27.3

57.7

32.3

24

.3

61.5

- 1.

02

0.53

3 0.

864

5.11

+ 5.

78

0.76

9

0.06

7

+ 1.

37

15.8

0.23

1 1.

47

0.13

7 -

0.43

2

11.3

3.

46

+ 0.

769

1.03

1.10

0.04

9

- 0.

577

0.32

3 -

0.13

5 -

0.77

9

+ 31

6-44

5(e)

+ lO

0(a)

+ lO

0 5.62

(c)

+ lO

0(a,

e)

178 75

.0(a

,e)

+ 10

00

+ lO

O0

+ 10

0(a)

75.0

(a,e

) +

100(

a,d,

e)

3.16

(a)

+ 10

0(a)

+

100-

212(

a,d,

e)

11

.3-

+50

.0(c

,d)

+ 10

0(a,

e)

+ 10

0(a,

e)

+ 10

0(a)

7.

50(a

,c,e

) +

100(

a)

+ 10

0(a,

e)

+ 10

0(a,

e)

+ 10

0(a)

10

00

+ 10

0(a,

e)

+ 10

0(a)

+

178(

a)

Cot

urni

x L

Dso

(m

g/kg

)

422

+ 1

00

- +

316(

m)

+ 31

6(m

)

+ lO

00(f

)

178

750

+ 10

00

+ 31

6(m

)

8,84

-10.

4(c)

+

316 lO

.O(c

)

562

31

6-+

31

6(0

O

Page 17: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

2-M

etho

xy- 1

,4-n

apht

hoqu

inon

e M

irex

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utan

e su

ffon

ic a

cid

Her

cule

s 39

44

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nom

ethi

onat

e D

odin

e 4-

Am

ino-

2-ch

loro

benz

oic

acid

M

erca

ptob

enzo

thia

zole

sod

ium

P

icry

l su

lfon

ic a

cid

Enc

ypra

te

Py

ram

at

2-B

rom

oeth

ylam

ine

HB

r D

ow E

T-1

5 B

ay 3

8920

p-

Chl

orop

heny

l N- m

ethy

lcar

bam

ate

Eth

yl-4

-chl

orop

heny

l car

bam

ate

Per

icya

zine

E

NT

256

70

Met

hioc

arb

sulf

oxid

e 3,

5-X

ylyl

N-m

ethy

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bam

ate

Bay

224

08

Chl

oron

eb

SD

853

0 E

ntic

ide

Dia

llyl

itac

onat

e 4-

Am

inob

enza

mid

e 5-

Am

ino-

o-cr

esol

D

owco

210

D

ID 9

5 be

ta-D

imet

hyla

min

oeth

yl m

etha

cryl

ate

1-A

min

o-4-

chlo

roan

thra

quin

one

tran

s-A

saro

ne

Sul

azep

am

RE

565

5 C

hlor

pyri

fos

Bay

429

03

2-(M

ethy

lthi

o)an

ilin

e E

NT

624

88

Hex

amet

hylt

riet

hyle

nete

tram

ine

Acr

izan

e ch

lori

de

d-C

arnp

hors

ulfo

nic

acid

A

cid

fuch

sine

A

spon

G

C 6

506

Her

cule

s 96

99

N- C

yclo

hexy

l- 1

,3-p

ropa

nedi

amin

e C

yclo

hexy

lpip

erid

ine

O,S

,S-T

ride

hylp

hosp

horo

trith

ioic

aci

d T

emep

hos

3-A

min

oben

zam

ide

R-8

74

Pim

etin

e B

ay 3

2651

B

ay 3

4042

R

epel

lent

120

7 E

thox

oman

e 2-

Chl

oroe

thyl

met

hane

sulf

onat

e T

PT

Z

SD

772

7 S

ulfo

tepp

2348

825

2385

855

2386

472

2425

050

2439

012

2439

103

2457

763

2492

264

2508

192

2521

019

2532

492

2576

478

2591

664

2592

623

2620

533

2621

809

2622

266

2631

405

2635

101

2655

143

2668

920

2675

776

2686

999

2728

021

2767

999

2835

689

2835

952

2864

611

2865

705

2867

472

2872

471

2883

989

2898

137

2917

193

2921

882

2984

658

2987

533

3054

215

3083

101

3131

086

3144

169

3244

880

3244

904

3254

635

3279

467

3312

605

3319

015

3347

306

3383

968

3544

249

3547

339

3565

035

3566

005

3568

567

3569

571

3570

465

3570

589

3682

357

3687

136

3689

245

316

+ 10

0(a)

+ 1

00

- +

500(

a)

+ lO

O- +

500

+ 31

6

+ 10

0 +

100(

a,e)

+ (1

04)

+ 40

0 +

28.0

(a)

+ 10

0(a,

d,e)

+

lO0(

a)

100(

a)

56.2

1.

78-3

.16(

a)

75

.0-

80.0

(a,d

,e)

17.8

-31.

6 +

100(

a)

10.0

-31.

6(a,

e)

+ 10

0(a)

+ 10

0o

+ 10

00

23.7

(a,e

) lO

0(a)

+

(98.

0)

+ (2

7.0)

75

O

+ lO

IXa,

e)

2.37

-3.0

0(a,

d,e)

13

.3(a

,c,e

,h)

5.62

(a)

+ 10

00

10.0

+

100

+ 17

8 +

100

+ lO

0(a)

0.

562(

a)

45.0

(a,d

,e)

+ (4

0.0)

+

(98.

0)

42.2

(a)

1000

+

100

+ lO

0(a)

67

.0-7

0.O

(a,d

) -

0.31

6(a)

+

100

100(

a,e)

+

100 5.

62

lO0(

a)

+1.

00

+ 1.

00

+ 1.

00

0.74

0 +

0.3

16

- +

1.00

0

.40

0-0

.62

0

+1.

oo

+ 1 .

oo

+ 1.

00

+1.

00

0.26

0 +

1.00

O

. 150

0.

050

+I.

00

0.

422

0.65

0 0.

487

0.12

1 +

1.00

0.

020-

0.05

0 +

1.00

+

1.00

+

1.00

+

1.00

+

1.00

+

1.00

0.05

6 +

1.0o

0.

600

0.23

7 +

1.0o

0.

050

0.08

3(h)

+ 1.

00

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oo

+ l.O

O

o.2

1o

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37

+

1.oo

+

1.oo

o.

150

0.

035

o. 8

00

o.31

6 +

1.o0

+

o. lO

O

+ 1.

00

+ 1.

o0

+ 1.

oo

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0o

0.0

02

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20

+1.

00

+1.

0o

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oo

o. 1

68

0.56

2 0.

060

+76

.9

56.9

11.5

3.

85

32.3

50

.0

37.5

9.

31

+76

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3.85

+76

.9

4.31

46.2

18

.2

3.85

6.

38

+ 76

.9

11.5

2.

69

61.5

24

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+76

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+76

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1.54

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12.9

4.62

+ 0.

243

- 0.

114

- 0.

029

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38

- 0.

323

0.50

0 0.

666

5.23

+

1.03

0.

216

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69

0.04

3

1.71

0.

024

1.

62

0.48

0

+ 7.

69

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115

4.79

1.

37

- 0.

615

+ 1.

82

+ 0.

077

0.02

3

+ 0.

769

2.30

+ 0.

046

+ 56

2

+ 50

0

+ 31

6

+ 10

0(a,

e)

+ 50

0(a)

50.O

(a)

+ lO

0(a,

d,e)

+

lO0(

a)

1000

(a)

+ 10

0(a,

d,e)

50

0(a)

+

lO0(

a)

+ lO

0(a,

e)

+ 10

0(a)

+ 10

00

+ 10

00

+ 10

0(a,

e)

+ 10

0 +

100(

a,e)

5.

62(a

,d,e

) 75

.0(c

,e)

31.6

(a)

+ 10

00

+ 10

0(a)

0.

562(

a)

45.0

(a,d

,e)

+ 10

0(a)

+

1000

+ 10

0 (a

) 57

.0-6

5.0(

a,d)

1.

78(a

)

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0(a,

e)

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0

100(

a)

i + 31

6

+ 31

6(m

)

+ 10

00

750

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0 13.3

(c)

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00

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6(t)

+

316(

m)

+ 1

00

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16

75.0

+

1000

q

178 -

237(

1)

75

.0-

+31

6(m

)

t~ W

Page 18: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Ta

bl

e

2.

(c

on

t'

d)

Nam

e

Chl

orop

haci

none

H

ercu

les

8717

1,

5-D

ichl

oro-

2,4-

dini

trob

enze

ne

2-P

icol

ylam

ine

3-P

icol

ylam

ine

4-A

min

omet

hylp

yrid

ine

Den

ato

niu

m

ben

zoat

e D

ilox

anid

e fu

roat

e E

NT

17

591

EN

T 6

249a

2-

Chl

oro-

4,6-

diam

ino-

1,3

,5-t

riaz

ine

Chl

orop

roca

ine

HC

1 S

D 8

786

Ro

nn

ox

on

D

owic

ide

Q

VC

3-6

68

Gop

haci

de

Eth

yl c

arb

azat

e 7

-Hy

dro

xy

-4,8

-dim

eth

ylc

ou

mar

in

Val

noct

amid

e S

udan

bla

ck B

2

-Ph

eno

xy

tetr

aby

dro

py

ran

K

elev

an

Tri

chlo

roac

etop

heno

ne

2-B

rom

oeth

ane

sulf

onic

aci

d N

a sa

lt

Ty

bam

ate

Rau

wol

fine

S

udan

gre

en

ME

S

Clo

thiz

amid

e di

mal

eate

2,

4,5-

Tri

met

hoxy

ben

zald

ehyd

e 4-

Mer

capt

opyr

idin

e T

hion

ieot

inam

ide

(+)-

Fen

cho

ne

Tri

octy

lpho

sphi

ne

5-C

hlor

oisa

toic

an

hydr

ide

Lil

ly 2

1784

3-

Pip

erid

ino-

l,2-

prop

aned

iol

Pen

tyl-

2-fu

roic

aci

d 4-

Ace

tam

idop

yrid

ine

Car

boxi

n M

etom

idat

e C

itra

l 3,

3'-T

hiob

ispr

opio

nam

ide

1,2,

5-T

riac

etox

y p

enta

ne

Cap

urid

e B

rom

chlo

ren

on

e D

imef

adan

e M

esor

idaz

ine

Thi

othi

xene

C

hlor

pyri

fos-

met

hyl

Do

wco

217

Reg

istr

y

LD

z0

nu

mb

er

(mg/

kg)

(CA

S)

(1,2

,5)

3691

358

3692

908

3698

837

3731

519

3731

520

3731

531

3734

336

3736

810

3737

222

3750

434

3797

624

3858

897

3971

899

3983

457

4080

313

4104

034

4104

147

4114

312

4115

768

4171

135

4197

255

4203

503

4234

791

4252

782

4263

529

4268

364

4360

127

4392

681

4432

319

4434

202

4460

860

4556

234

4621

663

4695

629

4731

537

4743

173

4806

875

4847

932

4996

489

5221

421

5234

684

5377

208

5392

405

5459

109

5470

860

5579

135

5579

851

5581

408

5588

330

5591

457

5598

130

5598

527

+ lO

0(a)

15

.0(a

,d,e

) +

100

562

+ 10

0o

+ 1

00

-+

1000

+

100

+ (9

8.0)

+

100 13

.3

+ 10

0 +

100(

a,e)

42

.2(a

,e)

17.8

(a,e

) +

100(

a)

4.2

2-4

.46

2

3.7

-+1

00

+

100

+ lO

0(a,

e)

+ 1

00

- +

50

0

+ 10

00

+ (l

O4)

+

100

+ 10

0 +

lO0(

a)

178

+ 50

0 +

100

+ lO

0(a,

e)

422

+ 10

0 +

100

+ 31

6 +

(98.

0)

+ 10

0 75.0

(a,e

) +

100

+ (9

8.0)

42

.2(a

) 42

.2

56

.2-

lO0(

a,e)

+ (9

8.0)

+

100(

a,e)

+

(42.

1)

75.0

(a,e

) +

100(

a)

+ 10

0(a,

e)

100 13

.3(a

,e)

Red

win

ged

b

lack

bir

d

Rs0

H

azar

d

Sta

rlin

g R

s0

(mg/

kg)

fact

or

LD

so

(%)(

5)

(3)

(4)

(mg/

kg)

0.31

6 24

.3

1.62

+

29

.0-1

50(a

,d,e

) 0.

824

63.4

-

0.63

4 --

+

1.00

+

7.69

+

0.13

7 +

1000

+

1.oo

--

--

+

100o

0.

856

65.8

-

0.06

6 +

1000

+

1.00

--

--

--

+

1.00

-

-

--

-

-

+ 1.

00

--

--

--

--

--

--

23.7

+

1.00

-

-

--

-

-

+1

.0

0

--

-

-

--

0.5

62

43

.2

1.03

+"

10

0(a,

e)

0.40

0 30

.8

1.73

+

100(

a,e)

+

1.

00

-

-

--

+

lO0(

a)

+1.

00

--

-

-

--

--

--

--

17

.8(a

,e)

0.54

0 41

.5

1.75

10

0 +

1.00

-

-

--

-

-

+1

.0

0

--

-

-

+ lO

0(a

,e)

+1

.00

-

-

--

-

-

+ 1.

00

--

--

--

+1

.0

0

--

-

-

--

+ 1.

00

--

--

--

+1

.0

0

--

-

-

--

+1

.0

0

--

-

-

+ lO

0(a)

+

1.00

+

76.9

+

0.43

2 -

-

+1

.0

0

--

-

-

--

+1

.0

0

--

-

-

--

0.6

50

50

.0

- 0.

500

+ 10

0(a,

e)

+1.

00

+76

.9

+ 0.

182

--

+1

.00

-

-

--

-

-

+1

.0

0

--

-

-

--

+1

.0

0

--

-

-

--

+1

.0

0

--

-

-

--

+1

.0

0

--

-

-

--

+1

.0

0

+76

.9

+ 1.

03

+ 10

0(a,

e)

+1.

00

--

-

-

--

+1.

o0

--

--

--

--

--

--

13.3

(a)

+1.

00

+76

.9

+ 1.

83

--

+1.

00

+76

.9

+ 1.

37

17

8-

+ 17

8(e)

+ 1.

00

--

--

--

+1.

00

--

-

-

--

+ 1.

00

--

-

-

lO0(

e)

0.31

6 24

.3

- 0.

577

--

0.93

0 71

.5

0.95

4 +

lO0(

a,e)

0.

562

43.2

-

0.43

2 +

lO0(

a)

+1

.0

0

--

-

-

+ 10

0(a,

e)

+1.

00

+76

.9

+ 0.

769

+ 10

0 0.

154

11.8

0.

890

56.2

(a,e

)

Cot

urni

x L

Ds0

(m

g/kg

)

750

+10

00

+ 10

00

75

.0-+

10

0(D

+

316

100(

m)

+ 10

00(~

+ 10

0(m

)

+ 31

6(m

)

750

t~

::Y

e~

Page 19: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Ch

lore

that

e 56

3437

7 +

10

0(a,

e)

+ 1

.00

l-B

orn

yla

ceta

te

5655

518

316

+ 1

.00

Ace

top

hen

zain

e m

alea

te

5714

001

75

,0(a

,e)

+1

.00

E

thyl

-4-n

itro

phen

yl c

arb

amat

e 58

1921

6 75

.0(a

) 0.

316

Ch

loro

pro

py

late

58

3610

2 +

10

0 +

1.0

0

Ben

aphy

llin

58

7861

5 +

10

0 0.

422

4-P

rop

ylv

erat

role

58

8852

8 +

31

6 +

1.0

0

Nar

len

e 59

0252

3 75

.0 (a

) 0.

030

1,3-

Bis

(dim

ethy

lam

ino)

isop

ropa

nol

5966

518

+

100

+1

.00

B

eno

xin

ate

HC

I 59

8782

6 13

3 +

1.0

0 d-

Lim

on

ene

5989

275

+

(Ill

) +

1.0

0

N 2

44

6012

926

+

100(

a)

0,0

20

-0,1

10

p

-Am

ino

pro

pio

ph

eno

ne

HC

1 61

7025

8 23

7 --

p

-Am

ino

pro

pio

ph

eno

ne

SO4

6170

269

133

--

p-T

olu

enes

ulf

on

ic a

cid,

mo

no

hy

dra

te

6192

525

+

100

+I.

00

M

orin

HC

1 62

0227

3 +

10

0 +

i.0

0

Tri

ally

l ci

trat

e 62

9973

6 --

+

1.0

0 4-

Chl

oro-

2,5-

dim

etho

xyan

ilin

e 63

5864

1 +

10

0(a)

+

1.0

0 B

ithi

onol

ate

sodi

um

6385

586

+

(75.

0)

0.75

0 A

lty

xy

carb

63

9246

7 13

,3(a

,d,e

) 0.

100

3-C

Mo

rob

enza

nth

ron

e 64

0944

5 --

0.

340

Tri

do

dec

ylp

ho

sph

ine

64 1

1241

+

(9

8.0)

+

1.0

0 H

RS

163

5 64

3605

1 75

.0(a

) 0.

422

So

diu

m s

ilic

ate

6834

920

+

(100

) +

i.0

0

Mo

no

cro

top

ho

s 69

2322

4 1.

00(a

,b,c

,e)

0.05

6 2

-Ben

zyla

min

o p

yri

din

e 69

3527

9 +

10

0 --

4

-Ch

loro

-2,5

-dim

eth

ox

yn

itro

ben

zen

e 69

4053

0 +

10

0 0.

680

2-C

h[or

o-4-

acet

otol

uidi

de

7149

793

1.78

(a)

0.2

82

- +

1.0

0 H

EP

ES

73

6545

9 +

10

0 +

1.0

0

Dim

eth

ylo

cty

lam

ine

7378

996

+

(101

) +

1.0

0

4-C

hlor

opyr

idin

e H

CI

7379

353

+

10

0-

+ 1

000

+ 1

.00

Alu

min

um

74

2990

5 +

(l

id

+1

.00

C

arb

on

74

4044

0 +

(1

00)

+ 1

.00

Th

alli

um

sul

fate

74

4618

6 --

+

1.0

0 L

ith

ium

chl

orid

e 74

4741

8 42

2 +

1.0

0 T

rich

loro

mel

amin

e 76

7309

8 +-

10

0 +

1.0

0 S

odiu

m f

luor

ide

7681

494

--

+ 1

,00

Bay

755

46

7682

908

2,37

(a,b

) 0.

056

Cro

tox

yp

ho

s 77

0017

6 56

.2

0.64

9 S

ulfu

r 77

0434

9 --

+

0.3

16

- +

1.0

0 S

tarl

icid

e 77

4589

3 2.

41(a

,j)

0.80

0 3-

Bro

mo-

p-to

luid

ine

7745

917

1.90

(a)

0.76

0 D

ow

co 1

05

7780

338

600

0.09

0 P

ota

ssiu

m a

lum

do

dec

ahy

dra

te

7784

249

+

(100

) +

1.0

0

Am

mo

niu

m a

lum

77

8425

0 +

(1

00)

+1

.00

P

ho

sdri

n

7786

347

1.78

(c)

--

Bo

ne

oil

8001

852

--

+ 1

.00

Nee

m o

il

8002

651

I00

0-

+ 1

000

+1

.00

C

hem

agro

263

5 80

0346

1 +

10

0(a)

-0

.10

0

Cin

nam

on

oil

80

0780

5 +

10

00

+ 1

.00

Dit

ran

80

1554

1 +

10

0(a,

e)

--

Ver

atri

ne

8051

023

17.8

0.

178

Lig

nosu

lfon

ic a

cid

sod

ium

80

6151

6 +

10

0 +

I.0

0

Bu

fen

carb

80

6536

9 4.

22(c

) +

1.0

0 D

emet

on

80

6548

3 2

,37

-22

.0(a

,b,c

) --

C

alci

um

nit

rate

10

1243

75

+

(99.

0)

+1

.00

B

ES

10

1911

81

+

100

+1

.00

N

arin

gin

10

2364

72

+

100

+ 1

.00

Res

met

hri

n

1045

3868

75

.0

+ 1

.00

Pro

pin

eb

1207

1839

+

10

0 --

Z

ineb

12

1226

77

+

100(

a)

+1

.00

-2.5

5

Man

eb

1242

7382

+

10

0 +

100

m +

76

,9

+7

6,9

24

.6

32.5

2.31

+7

6.9

8.46

+7

6.9

57

.7

%69

32.3

4.31

52,3

+

76

.9

+7

6.9

4.31

49

.9

61.5

58

.5

6.92

+7

6.9

- 7.

69

13.7

+7

6.9

+7

6.9

196

+

0.24

3 +

1.

03

0.32

8

- 0.

325

0.03

1

- 0.

578

- 0.

085

+

0.76

9 -

0.76

9 6,

578

0.43

1

4.31

- 0,

523

+4

3,2

+

0.18

3

1.82

0.

888

25.5

30

.8

0.01

2

+

0.07

7 --

0.0

77

0.77

0

+18

.3

+

1.03

- 1.

96

+

lO0(

a,e)

1O0(

a,e)

+

lO

0(a)

+

316

422

+

178

+

100(

a)

10

.0-1

3.3

(a,d

,e)

+

lO0(

a)

3.1

6-5

.62

(a,c

,e)

+

100 1.

33(a

)

+ 1

000 34

.6-

56.6

(a)

+ 1

000

+

200

+

100(

a)

3.1

6-4

.1 l

(aj,

k)

6.6

0-7

.50

(a)

3.9

0-7

.50

(a,c

)

+

100(

a)

+

100(

a,e)

75 0

(c)

13

.3-

+3

9.0

(a,c

)

+

100

m

m

+

lO0(

m)

+

316(

m)

lO0(

m)

133

+

178

+

316 4.

22(c

)

1,33

+

31

6(m

)

+ 1

000

422 2

.24

- lO

.O(j

)

23,7

(c)

42, 2

- 56

,2(c

) 13

.3(c

)

+

316(

m)

c~

Page 20: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 2

. (c

on

t'd

)

Nam

e

GC

594

2 Ph

illip

s 26

05

Mic

olut

eina

des

taci

na

(l-A

dam

anty

l) ure

a 5-

Ani

lino

- 1,2

,3,4

-thi

atri

azol

e E

NT

273

18

SD

141

14

Tit

aniu

m d

ioxi

de

Wy

524

4 F

ench

yl

acet

ate

Am

ino

met

han

esu

lfo

nic

aci

d F

enp

ipra

mid

e H

CI

Tri

met

hid

iniu

m m

eth

osu

lfat

e A

CD

702

9 S

D 3

450

Ba

3321

5 B

is(1

,2,2

-tri

chlo

roet

hyl)

sulf

oxid

e P

ho

xim

B

ay 7

8172

be

ta-I

onon

e C

ryol

ite

2-C

hlor

oeth

ane

sulf

onic

aci

d N

a sa

lt

Tri

ph

eny

llea

d p

hen

yl

sulf

ide

Ry

ania

C

yp

raze

pam

al

pha-

Chl

oral

ose

RE

545

4 2,

3,4-

Tri

chlo

roph

enol

E

PP

S 3

-Am

ino

-5-m

erca

pto

-l,2

,4-t

riaz

ole

M

eth

om

yl

4'-

Ace

tam

ido

pro

pio

ph

eno

ne

Ed

infe

np

ho

s X

anth

iol

HC

I 2

,2,2

-Tri

chlo

roet

hy

leh

loro

form

ate

To

mat

ine

5-A

min

o-3-

phen

yl- 1

,2,4

,-th

iadi

azol

e 3-

Am

ino-

5,6-

dim

ethy

l- 1,

2,4-

tria

zine

1,

2,4-

tria

zine

D

od

ecy

lam

ine

pic

rate

B

eno

my

l B

rom

op

rop

yla

te

Bay

690

47

Thi

oglu

cose

C

alci

um s

ulfi

de

Pot

assi

um a

zide

C

hlo

ran

ifo

rmet

han

M

etri

buzi

n 4

-Cy

clo

hex

ylt

hio

sem

icar

baz

ide

Reg

istr

y

nu

mb

er

(CA

S)

1270

7607

12

7122

86

1276

4475

13

0726

90

1307

8303

13

1944

84

1335

6086

13

4636

77

1382

2054

13

8511

11

1388

1919

14

0075

35

1414

9430

14

2854

39

1445

8958

14

5484

60

1478

8977

14

8161

83

1481

6207

14

9010

76

1509

6523

15

4844

43

1559

0779

15

6623

36

1568

7077

15

8799

33

1594

2480

15

9506

60

1605

2065

16

6914

33

1675

2775

16

9604

99

1710

9498

17

1623

22

1734

1934

17

4064

50

1746

7151

1758

4122

17

6234

15

1780

4352

18

1818

01

1964

5422

20

4089

73

2054

8543

20

7626

01

2085

6579

21

0876

49

2119

8185

LD

s0

(mg/

kg)

(1,2

,5)

Red

win

ged

b

lack

bir

d

Rs0

(%

)(5)

R~0

(mg/

kg)

(3)

Haz

ard

fa

cto

r (4

)

Sta

rlin

g L

D,~

o (m

g/kg

)

+

100(

a)

2.37

(a)

2.37

(a)

+

100

+

100 4.

22(c

) +

10

0 10

0 1

00

- +

100

(a,e

) +

31

6 +

10

0

+

100(

a,e)

31

.6(a

,e)

- (2

5.0)

(a)

+

100

+

100 10

.0(c

) +

10

0 +

56

2 +

lO

0(a)

+

10

0 +

(lOO

) 1.78

(c)

+

lO0(

a,e)

31

.6(a

,e)

9.00

(a,d

,e)

+

100

+

100

+

100 10

.0(a

,c,e

) +

31

6 +

10

0 +

10

0(a,

e)

+

100

+

100 56

.2-

+ 1

00

+

100

+ (l

O4)

1

00

- +

100

(a)

+

100

+

(113

) +

10

0 17.8

+

10

0 +

10

0 +

10

0

0.20

0 0.

178

0.15

0 +

1.0

0 0.

453

+ 1

.00

+1

.00

+

1.0

0

+ 1

.00

+ 1

.00

0.28

2 +

1.0

0 0.

400

-1.0

0

+ 1

.00

+0

.10

0

+1

.00

+ 1

.00

+1

.00

+

1.0

0 +

1.0

0 0.

133

0.90

0 +

1.0

0 0.

316

+ 1

.00

+ 1

.00

+ 1

.00

0.22

4

+ 1

.00

0.65

0 +

1.0

0

+ 1

.00

0.42

2

+ 1

.00

+ 1

.00

+ 1

.00

+ 1

.00

+ 1

.00

+ 1

.00

+1

.00

+

1.0

0 +

1.0

0 +

1.0

0 0.

299

15.4

13

.7

11.5

34.8

+7

6.0

+

76

.9

30.8

+7

6.9

10.2

69

.2

+7

6.9

24

.3

17.2

50.0

32.5

+7

6.9

+7

6.9

2310

- 0.

154

5.78

4.

77

- 0.

348

+

0.76

9 +

0.

769

0.97

4

+

7.69

5.75

-

0.69

2 2.

43

2.70

1.72

- 0.

500

0.57

7

+ 0

.769

+

4.32

- 0.

230

100(

a)

17.8

(a)

2.3

7-3

.16

(a)

7.50

(c)

+

100

+

100(

a,e)

+

100(

a,e)

+

lO0(

a)

23.7

(c)

+

lO0(

a)

3.16

(c)

+ lO

0(a,

e)

75.0

(a,e

) 16

.0(a

,d,e

)

13

.3-4

2.2

(a,c

,e)

+

316

+ lO

0(a,

e)

+

lO0(

a)

Co

turn

ix

LD

~0

(mg/

kg)

+

100

+

316(

m)

7.50

(c)

+ 1

000(

f)

23.7

(c)

+ 1

000(

f)

13.3

(c)

31.6

+-3

16

(m)

+

316(

m)

23.7

(c)

+

316 75

.0(m

)

+

316(

m)

+

316(

m)

+

316

O~

Page 21: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tin

ox

ide

2165

1194

+

(1

03)

+1

.00

--

--

--

C

yan

azin

e 2

17

25

46

2

--

0.13

3 --

--

--

B

ay 9

015

21

83

22

57

13

.3(a

) +

0.1

00

+

7

.69

+

0.

587

13.3

(a)

Pir

imip

ho

s-et

hy

l 23

5054

11

7.5

0

0.6

04

4

6.4

6

.19

+

10

0 B

ay 9

3820

24

3536

15

0.5

62

(b)

0.0

24

1.

85

3.52

--

R

esci

nn

amin

e 2

48

15

24

5

+

10

0(a

,e)

..

..

B

ay 9

1273

25

2050

87

--

0.0

42

--

--

--

P

rop

iop

rom

azin

e 2

53

33

83

9

+

316

0.4

65

3

5.8

-

0.11

3 31

6 S

od

ium

azi

de

2662

8228

2

3.7

+

1.0

0 +

76

.9

+

3.2

4

--

Py

rid

yl

dis

ulf

on

ic a

cid

-l,2

,4-t

riaz

ine

2804

8331

+

10

0 +

1.0

0

--

--

--

Tar

tar

emet

ic

2830

0745

+

10

0 0.

133

10.2

-

0.1

02

--

T

hio

carb

ox

ime

29

11

88

74

4

.22

0

.14

7

11.3

2

.69

--

C

yan

op

yri

din

e 29

3866

61

+

I00

+

1.0

0

--

--

--

Bay

798

45

3257

5807

3.

16(g

) 0

.05

6

4.31

1.

35

7.50

(a)

Bay

889

91

3257

5818

--

+

1.0

0

--

--

--

Tri

bu

tylt

in c

hlo

roac

etat

e 3

35

50

22

0

+

(39.

0)

0.3

16

24

.3

- 0.

623

--

Ch

emag

ro 5

461

3449

1128

+

10

.0(a

) 0

.56

2

43

.2

- 4

.32

+

10

.0(a

) D

imet

hy

ldin

itro

car

ban

ilid

e 34

5944

73

+

100

0.8

24

6

3.4

-

0.63

4 --

B

ay H

OL

057

4 3

53

35

60

5

2.37

(b)

0.4

80

3

6.9

15

.6

13.3

3-

Io d

o-p-

tolu

idin

e 3

59

44

64

0

1.78

- 2.

37(a

) 0

.15

0

11.5

6.

48

23

.7

Ph

illi

ps

2133

35

9447

31

1.7

8-2

,10

(a)

0.0

80

6.

15

3.4

6

1.33

(a)

Met

om

idat

e H

CI

35

94

47

42

5

6.2

(a,e

) 0.

667

53.1

0.

913

+

10

0(a

,e)

Do

wc

o2

11

3

59

44

79

7

75

.0(a

,e)

+1

.00

+

76

.9

+

1.03

+

10

0(a,

e)

Do

wco

16

0 3

59

44

82

2

10.0

(a,e

) 0

.50

0

38.5

3.

85

17.8

(a,e

) D

ow

co

133

3594

4833

7.

50(a

) 0

.50

0

38.5

5.

13

+

100(

a)

GC

42

76

3

59

44

86

6

10.0

(a)

--

--

--

178(

a)

Do

wco

16

1 3

60

31

66

0

23

.7(a

,e)

0.5

00

38

.5

1.62

13

.3(a

,e)

Zir

am c

ycl

oh

exy

lam

ine

com

ple

x

3653

0231

31

.6(a

) 0.

621

47

.8

1.51

--

P

rop

oq

uad

HT

/12

37

2346

21

--

+1

.00

--

--

--

P

ho

stex

3

73

33

40

7

+

500

+1

.00

--

--

+

50

0 S

KF

10

812A

37

8413

31

+

178(

e)

+1

.00

+

76

.9

+

0.4

32

3

16

-+3

16

(e)

2-M

eth

yl-

p-a

min

ob

enzo

ic a

cid

3

86

67

55

9

+

316

+1

.00

--

--

+

31

6 G

uaz

atin

e 3

92

02

39

6

+

100

+ 1

.00

--

--

--

Bay

CO

E 3

664

3945

7244

2.

37(b

) 0

.56

2

43

.2

18.2

13

.3

Bay

CO

E 3

675

39

45

72

55

1.

33(b

) 0

.56

2

43

.2

32.5

4.

22

U 5

092

4206

2395

+

(1

13)

+ 1

.00

--

--

--

Eth

yl-

l-(h

yd

rox

ym

eth

yl)

pro

py

lcar

bam

ate

51

17

04

80

+

10

0(a)

+

1.0

0

--

--

+

100(

a)

Cro

tuli

n

52

96

44

28

+

(1

04)

+1

.00

--

--

--

4

-Py

rid

inee

than

esu

lfo

nic

aci

d

5305

4765

+

10

0 +

1.0

0 --

--

--

2

,5-B

is(4

-py

rid

yl)

-l,3

,4-t

hia

dia

zole

5

40

10

21

8

+

100

0.4

22

3

2.5

-

0.3

25

--

U

12

171

61

16

40

98

7

5.0

(c,h

) 0

.09

1-0

.17

8(*

) 13

.7

0.18

3 10

0(c)

A

lcia

n y

ello

w

6196

8761

+

17

8 +

1.0

0

--

--

--

Sir

mat

e 62

0463

71

--

+ 1

.00

--

--

--

l-(2

-Nap

hth

alen

ylc

arb

on

yl)

azir

idin

e 6

30

21

45

4

+

100

+ 1

.00

--

--

--

Mer

cap

toac

etan

ilid

e ca

rbam

ate

64

04

65

88

+

10

0(a)

0

.68

0

52.3

-

0.52

3 +

10

0(a)

V

C 3

-759

66

8693

30

--

+0

.10

0

--

--

--

Ter

git

ol

15-S

-9

6813

1408

+

10

00

--

--

--

--

q

m +

316

+

31

6(m

)

62

9-7

50

(0

56.2

+ 1

000

+

100(

m)

17

8-3

16

(f)

+

31

6(m

)

m"

r~

(1)

Let

ters

in

( )

in

dic

ate

pre

vio

usl

y p

ub

lish

ed s

ou

rces

fo

r d

ata

pre

sen

ted

as

foll

ow

s: (

a) S

chaf

er 1

972;

(b)

Sch

afer

et

al.

1973

b; (

c) S

chaf

er e

t al

. 19

79;

(d)

Sch

afer

et

al.

1967

; (e

) S

chaf

er e

t al

. 19

72;

(f)

Sch

afer

et

al.

1976

; (g

) S

chaf

er e

t al

. 19

77;

(h)

Sch

afer

et

al.

1971

; (i

) F

ran

k e

t al

. 19

70;

(j)

DeC

ino

et

al.

1966

; (k

) S

chaf

er e

t al

. 19

69;

(1)

Sch

afer

et

al.

1973

a; (

m)

Sch

afer

et

al.

1982

; (u

) S

hef

te e

t al

. 19

82.

(2)

Nu

mb

ers

in (

) i

nd

icat

e an

est

imat

ed L

D.~

0 b

ased

on

fo

od

co

nsu

mp

tio

n d

ata

ov

er

a 18

ho

ur

per

iod

.\In

Tab

les

2, 3

, an

d 4

, th

e +

si

gn

s =

>

, an

d t

he

- si

gn

s =

<

. (3

) C

alcu

late

d a

ssu

min

g 5

0% c

on

sum

pti

on

of

an a

ver

age

foo

d i

nta

ke

du

rin

g o

ne

feed

ing

ses

sio

n (

l.0

0g

) an

d a

n a

ver

age

bo

dy

wei

gh

t o

f 65

g.

(4)

Cal

cula

ted

by

th

e fo

llo

win

g f

orm

ula

: R

~0 (

mg

/kg

) (m

ax

imu

m v

alu

e)/L

Ds0

(m

g/k

g)

(min

imu

m v

alu

e) =

H

aza

rd F

act

or

(5)

Ad

dit

ion

al r

efer

ence

s d

elet

ed

fro

m t

able

b

ecau

se

of

spac

e li

mit

atio

ns

are

den

ote

d

by

an

(*

),

as

foll

ow

s: 5

04

24

5-R

edw

ing

ed b

lack

bir

d-L

D5

0-(

e,l)

; 6

71

04

5-R

edw

ing

ed

bla

ckb

ird

-LD

50

(d,e

); 2

03

26

57

-Red

win

ged

bla

ckb

ird

-LD

50

-(c,

d,e

,h);

6

11

64

09

8-R

edw

ing

ed b

lack

bir

d-R

50

-(c,

h).

(6

) L

C~

o (i

nh

alat

ion

) in

pp

m.

Page 22: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Tab

le 3

. A

cute

o

ral

tox

icit

y

of

186

chem

ical

s to

7 o

ther

b

ird

sp

ecie

s

Reg

istr

y

Nu

mb

er

LD

60

(mg

/kg

)(1

,2,3

) (C

AS

) H

SP

A

CG

RA

C

PIG

H

FIN

M

AL

D

RN

PH

Y

HB

B

5128

5 +

9.0

0

..

..

..

52

437

178(

e)

--

10

0-1

33

(e)

42.2

(e)

75.0

(e)

+ 1

00

(e)

13

3-+

13

3(e)

5522

1 +

10

00

.

..

..

.

5538

9 2

.37

-5.6

2(a

,b,c

) 4

.22

-7.5

0(c

) 1

.78

(a,c

) 13

.3

--

--

2.3

7

5638

2 1.

33(b

,c)

5.62

(c)

1.33

(c)

2.37

--

--

--

56

724

10.0

(b,c

) 3

.16

-4.2

2(c

) 5.

62(c

) 2

.37

--

--

--

57

330

75

.0(a

,e)

17

8(a

,e)

13

3(a

,e)

10

0-1

33

(a,e

) 7

5.0

(a,e

) +

10

0(a

,e)

10

0(a

,e)

58

36

6

100(

a)

..

..

..

58

899

56.2

(a)

+ 10

0(a)

.

..

..

5

96

76

+

10

00

.

..

..

.

6041

3 --

--

--

5.

62(a

) --

--

--

60

571

13.3

(c)

42.2

(c)

23.7

(c)

..

..

62

533

56

2

..

..

..

62

737

17.8

(c)

13.3

(c)

23.7

(c)

..

..

6274

8 1.

00

7.5

0

..

..

.

63

25

2

+ 10

0 .

..

..

.

6530

5 +

10

0(a

,e,h

) +

31

.6-+

10

0(a

,e,h

) 7

5.0

(a,e

) 1

00

-+1

00

(a,e

) 7

5.0

(a,e

) +

10

0(a

,e,h

) 4

2.2

(a,e

)

6625

1 +

(240

) .

..

..

.

71

27

2

+ 10

0 +

100

75

.0

+ 10

0 +

100

75

.0

+ 10

0 7

17

38

10

0(e)

--

+

10

0(e

) 1

78

(e)

+ 3

16

(e)

+ 1

00

(e)

+ 1

00

(e)

72

20

8

1.7

8(a

,c,k

) 0

.31

6-5

.62

(a,c

) 5

.62

(a,c

,k)

..

..

7

72

69

1

00

(a,e

) --

7

5.0

(a,e

) 13

3(a,

e)

56

.2(a

,e)

+ 1

00

(a,e

) 5

6.2

(a,e

) 77

281

+ 10

0(e)

--

24

2(e)

13

3(e)

+

10

0(e

) +

10

0(e

) +

10

0(e

) 7

99

36

+

100(

e)

+ 1

00

(e)

+ 1

00

(e)

+ 1

00

-+3

16

(e)

+ 1

00

(e)

+ 1

00

(e)

+ 1

00

(e)

80

00

2

+ 10

0 .

..

..

.

8465

1 +

100

..

..

..

88

686

+1

00

0

..

..

..

8

87

44

7

50

.

..

..

.

90

04

0

421

..

..

..

94

246

+ 10

0 +

I00

+ I0

0

I33

+ 10

0 +

100

+ 10

0

95

53

4

750

..

..

..

95

545

100

..

..

..

95

556

316

..

..

..

95

749

31

6(a

,k)

--

13

.3(a

,k)

--

42

.2

--

--

97

17

6

56.2

(c)

75.0

(c)

75.0

(c)

..

..

9

77

78

+

(244

) .

..

..

.

98

98

6

178

..

..

..

99

058

+1

00

0

..

..

..

99

092

+1

00

0

..

..

..

10

0550

+

10

00

.

..

..

.

1010

19

+ 10

0 .

..

..

.

1020

67

+ 10

0 .

..

..

.

1049

61

31

6-5

62

.

..

..

.

1062

29

+ (2

40)

..

..

..

10

6478

10

0 .

..

..

.

1064

90

237

..

..

..

10

6503

42

2 .

..

..

.

1065

14

+ (2

40)

..

..

..

10

8429

17

8 .

..

..

.

1084

52

+ 10

00

..

..

..

10

8894

I0

00

.

..

..

.

1089

96

1000

.

..

..

.

1090

02

1000

.

..

..

.

1090

68

+1

00

0

..

..

..

5~

O

Page 23: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

1090

91

+1

00

0

..

..

11

0861

+

10

00

.

..

.

1142

61

13

.3-1

5.0

(a,c

,d)

13

.3(a

,c,e

) 7

.50

(a,c

,d)

4.2

2-1

0.O

(a,d

,e)

17.8

(a,e

) 11

5388

+

lO0(

e)

--

+ lO

0(e)

+

10

0-1

33

(e)

+ tO

O(e

) 11

5446

13

3(a,

e)

--

56

.2(a

,e)

10

0-1

33

(a,e

) lO

0(a

,e)

1159

02

0.3

16

(b,c

) 0

.42

2(c

) 0

.56

2(c

) --

--

11

6063

0

.75

0(c

) 0

.75

0(c

) 3.

16(c

) --

--

11

8923

+

10

00

.

..

.

1201

27

+ (2

44)

..

..

12

2145

3

16

--

--

31

6 --

12

3308

17

8 .

..

.

1265

23

+ lO

0(e)

+

lO0

(e)

+ lO

0(e

) 23

7(e)

+

lO0

(e)

1330

62

+ 10

0 +

100

--

--

--

1372

68

+ 10

0 +

tO0

--

--

--

1373

04

+ 10

0 .

..

.

1416

62

4.2

2(b

,c)

1.78

(c)

4.22

(c)

--

--

1420

85

1000

.

..

.

1438

28

42.2

(a)

--

+ lO

0(a)

23

.7(a

) +

lO0(

a)

1491

55

+ 1

00

-31

6(e

) +

10

0(e

) +

lO0

(e)

237(

e)

+ 10

0(e)

1501

30

+1

00

0

..

..

2

97

78

9

1.O

0(c)

1.

33(c

) lO

.O(c

) --

--

2

97

97

2

4.22

(c)

3.16

(c)

2.37

(c)

--

--

29

79

94

3.

16(c

) 5.

62(c

) 4

.22

(c)

--

--

29

80

22

--

1.

33(a

) --

--

--

2

98

04

4

--

2.37

(a)

--

--

--

30

21

70

+

100

+ 10

0 +

100

+ 10

0 +

100

30

90

02

13

.3(c

) 7.

50(c

) 56

.2(c

) --

--

3

09

43

3

56

.2(a

,e)

--

133(

a,e)

5

6.2

(a,e

) 7

5.0

(a,e

) 3

15

18

4

7.50

(c)

7.50

(c)

5.62

(c)

--

--

32

79

80

5.

62(c

) 5.

62(c

) 13

.3(c

) --

--

3

33

41

5

7.50

(c)

7.50

(c)

3.16

(c)

--

--

34

05

78

+

lO0(

e)

+ lO

0(e

) +

31

6(e

) +

31

6-+

31

6(e

) +

10

0-+

31

6(e

)

35

00

38

+

10

00

.

..

.

3598

31

+ lO

0(e

) +

lO0

(e)

+ lO

0(e

) +

10

0-1

78

(e)

+ lO

0(e

) 4

38

41

5

+ 3

16

(e)

+ 1

00

(e)

+ lO

0(e

) 3

16

(e)

+ lO

0(e

) 4

39

14

5

+ 3

16

-+5

62

(e)

+ 1

00

-+3

16

(e)

+ 3

16

(e)

+ 3

16

(e)

+ 3

16

(e)

44

01

75

7

5.0

.

..

.

46

20

88

13

3 .

..

.

47

09

06

13

.3(c

) 17

.8(c

) 13

.3(c

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.7

--

48

02

28

+

100

..

..

50

0221

+

10

00

.

..

.

50

02

87

+

tO0

..

..

5

04

24

5

3.8

0-7

.50

(a,b

,c,1

) 2

.37

(c,1

) 7

.50

(c,1

) 5.

62(1

) 4

.22

(a,1

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50

42

90

75

.0

..

..

53

6903

7

50

.

..

.

5785

41

75

0

..

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5

86

95

8

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00

0

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6981

10

0 .

..

.

58

70

20

10

00

..

..

5

89

16

2

178

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91

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5

+ lO

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..

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61

57

47

56

2 .

..

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62

66

08

56

2 .

..

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62

66

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+

10

00

.

..

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62

95

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+

(240

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..

.

67

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45

4

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(a,d

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2.3

7(a

,e)

69

45

97

+

1000

.

..

.

81

49

15

+

(25

0)

..

..

8

72

85

5

+1

00

0

..

..

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-- 1

5.0

(a,d

) +

lO0(

e)

+ lO

0(a

,e)

+ 1

00

(e)

+ lO

0(a

) +

lO0

(e)

+ 10

0

+ lO

0(a

,e)

+ lO

0(e

)

+ lO

0(e

) +

10

0(e

) +

3 I6

- +

56

2(e

)

5.6

2-7

.50

(a,1

)

10

.0-

ll.O

(a,d

,e)

m

7.50

(a)

+ 1

00

(e)

10

0-

+ 1

00

(a,e

)

+ lO

0(e

)

178

(a,e

) +

10

0(e

)

+ 10

0

10

0(a

,e)

+ 1

00

(e)

+ lO

0(e

) +

lO0

(e)

+ 3

16

(e)

1.3

3(a

,e)

g W

"--4

Page 24: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Ta

ble

3

. (c

on

t'd

)

Re

gis

try

Nu

mb

er

LD

so(m

g/k

g)(

1,2

,3)

(CA

S)

HS

PA

C

GR

A

CP

IG

HF

IN

MA

LD

R

NP

H

YH

BB

87

37

45

5

6.2

.

..

..

.

93

11

91

+

10

00

.

..

.

__

94

42

29

1

3.3

(C)

17

.8(C

) 1

3.3

(C)

--

--

__

_

_

94

70

24

2

.37

(b,c

) 2

.37

(C)

2.3

7(C

) --

--

_

_

__

95

69

01

1

33

(a,e

) 1

33

(a,e

) 1

33

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7(a

,e)

75

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,e)

75

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,e)

13

3(a

,e)

23

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,e)

10

03

67

4

+1

00

0

..

..

10

03

73

2

+1

00

0

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_

10

79

33

0

23

.7(c

) 1

7.8

(c)

56

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) --

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_

__

1

12

16

04

1

00

0

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..

_

_

11

22

54

9

10

00

.

..

.

__

11

22

62

9

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00

0

..

..

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93

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8

56

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..

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05

62

0

+

56

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..

..

_

_

13

14

41

6

+

(19

5)

..

..

_

_

13

28

53

6

+

(27

8)

--

--

--

__

_

_

13

29

86

8

+

31

6

+

10

0

+

10

0

+

10

0

+

10

0

+

10

0

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10

0

13

71

39

1

+

(10

0)

..

..

_

_

14

61

22

9

+

10

0

..

..

15

63

66

2

1.3

3(b

,c)

1.3

3--

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6(c

) 1

.33

(c)

0.7

50

--

--

--

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78

38

19

5

62

.

..

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__

18

85

29

6

+1

00

0

..

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32

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,h)

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(a,*

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0(a

,d,e

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(a,e

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00

0(a

,*)

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6(a

,e)

21

04

64

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7(c

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2(c

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..

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22

37

30

1

56

2

..

..

..

28

35

68

9

10

00

.

..

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28

35

95

2

56

2

--

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--

28

64

61

1

56

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) 5

6.2

(a,e

) +

3

16

7

5.0

(a)

75

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00

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1

00

(a)

+

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0(a

) 2

86

57

05

1

00

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..

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..

29

21

88

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10

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3.3

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2

98

75

33

1

00

0

..

..

33

83

96

8

31

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44

24

9

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00

0

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..

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31

51

9

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00

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31

52

0

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00

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..

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31

53

1

10

00

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41

04

14

7

--

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.

..

.

53

77

20

8

31

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,e)

56

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,e)

42

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,e)

56

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,e)

13

3(a

,e)

+

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0(a

,e)

75

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) 5

39

24

05

+

(24

0)

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..

..

59

02

52

3

+

10

0

..

..

..

60

12

92

6

+

10

0

..

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6

92

32

24

1

.33

(b,c

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.22

(c)

4.2

2(c

) --

--

_

_

__

71

49

79

3

..

..

4

2.2

--

--

73

79

35

3

+1

00

0

..

..

..

74

29

90

5

+

(25

0)

..

..

..

76

82

90

8

3.1

6(b

) 1

0.0

4

.22

5

.62

--

1

7.8

2

.37

77

45

89

3

31

6-4

48

(aj,

k)

1.0

0

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j,k

) +

2

25

(a)

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j)

10

.0(a

j)

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80

33

8

+

I00

.

..

..

.

77

86

34

7

1.7

8(c

) 4

.22

(c)

4.2

2(c

) .

..

.

80

65

36

9

23

.7(c

) 4

2.2

(c)

23

.7(c

) +

3

.16

(c)

--

--

--

80

65

48

3

5.6

2(b

,c)

1.7

8(e

) 1

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(c)

..

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45

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68

+

1

00

.

..

..

.

12

71

22

86

.

..

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1

5.3

13

19

44

84

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.0(c

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28

54

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00

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3.3

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1

00

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3.3

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) 1

48

16

18

3

5.6

2(c

) 7

5.0

(c)

23

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) .

..

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O0

Page 25: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

1481

6207

+

100

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0 --

--

--

+

100

1559

0779

+

100

..

..

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1566

2336

2.

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) 1.

78(c

) 2.

37(c

) --

--

--

15

8799

33

42

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,e)

75

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,e)

17

8(a

,e)

56

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,e)

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,e)

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00

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) 16

7527

75

13

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13

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3.7

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10.0

(c)

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85

65

79

+

100

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0 .

..

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21

08

76

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+

lOO

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.

..

.

24

35

36

15

1.

O0(

b)

..

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.

32

57

58

07

1.

78

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7

2.37

--

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53

35

60

5

3.16

(b)

7.5

0

7.5

0

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3

59

44

73

1

..

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2

35

94

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94

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62(a

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,e)

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37

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31

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100(

e)

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6(e

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62(b

) 5.

62

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39

45

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1.

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37

7.5

0

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6

11

64

09

8

+ lO

0(h

,i)

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0(h

,i)

--

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+ lO

0(h

)

m m

133(

a,e)

56

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)

10

.0(a

,e)

+ 1

00

(e)

~r

t~ W

N

(1).

Sp

ecie

s co

des

ar

e id

enti

fied

in

Tab

le

1.

(2).

Let

ters

in

( )

in

dic

ate

pre

vio

usl

y

pu

bli

shed

so

urc

es

for

dat

a p

rese

nte

d

as f

oll

ow

s:

(a)

Sch

afer

19

72;

(b)

Sch

afer

et

al.

1973

b; (

c) S

chaf

er e

t al

. 19

79;

(d)

Sch

afer

et

al.

19

67;

(e)

Sch

afer

et

al.

19

72;

(f)

Sch

afer

et

al.

19

76;

(g)

Sch

afer

et

al.

19

77;

(h)

Sch

afer

et

al.

19

71;

(i)

Fra

nk

, et

al.

19

70;

(j)

DeC

ino

et

al.

19

66;

(k)

Seh

afer

et

al.

19

69;

(1)

Sch

afer

et

al

. 19

73a;

(m

) S

chaf

er

et a

l.

1982

; (n

) S

hef

te e

t al

. 19

82.

(3).

Ad

dit

ion

al

refe

ren

ces

del

eted

fr

om

ta

ble

bec

ause

o

f sp

ace

lim

itat

ion

s ar

e d

eno

ted

b

y a

n (

*),

as f

oll

ow

s:

20

32

65

7-C

om

mo

n

pig

eon

-(c,

d,e

);

20

32

65

7-R

ing

-nec

ked

p

hea

san

t-

(d,e

,h)

Tab

le

4.

Acu

te

ora

l to

xic

ity

an

d

rep

elle

ncy

o

f 9

1

chem

ical

s to

5

8

oth

er

bir

d

spec

ies

Reg

istr

y

Nu

mb

er

LD

so(m

g/k

g)(

1,2

) (C

AS

) O

ther

sp

ecie

s O

ther

sp

ecie

s O

ther

sp

ecie

s H

SP

A

51

28

5

--

--

--

0.6

00

5538

9 ak

es

1.0

0-1

.33

(a)

bb

mp

4

.22

- 5

.62

(a)

bh

cb

7.5

0

--

md

ov

2.

37

rbq

u

1.33

(b)

rob

i 5.

62

--

5638

2 b

hcb

1.

33

rbq

u

1.78

(b)

vw

ea

+ 1.

78

--

56

72

4

bh

cb

1.00

rb

qu

3.

16(b

) --

--

5

80

82

.

..

.

5836

6 --

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+

1.0

0

58

89

9

ccro

+

100(

a)

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0.2

20

60

413

robi

+

lO.O

(a)

--

--

--

63

25

2

--

--

--

0.3

16

6

53

05

b

hcb

3

1.6

(a,e

) cc

ro

42

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,e)

wcs

p

56.2

(a)

0.5

62

(h)

6625

1 --

--

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+

1.0

0

70

69

9

bb

mp

17

8 cc

ro

178

--

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7220

8 ak

es

1.50

(k)

mp

ar

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10

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8000

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8465

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95

74

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4

22

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g

31.6

rb

qu

3

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(a)

tcb

b

2.37

--

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97

778

--

--

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+1

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9

99

23

b

bm

p

178

ccro

17

8 --

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10

1019

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0

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0

1020

67

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24

10

6229

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+

1.o

0

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14

--

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+1

.oo

R50

(%)

Oth

er

spec

ies

Oth

er

spec

ies

yh

bb

cgra

rnp

h

cgra

yh

bb

m m

m

0.4

30

0.12

1

+ 1.

00

O. 1

76(h

)

O. 1

50

rnp

h

rnp

h

q m

m

i + 1.

oo

0.4

22

(h)

XD

Page 26: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

Ta

ble

4

. (c

on

t'd

)

Re

gis

try

Nu

mb

er

LD

so(m

g/k

g)(

1,2

) R

~o

(%)

(CA

S)

Oth

er

spe

cie

s O

the

r sp

ec

ies

Oth

er

spe

cie

s H

SP

A

Oth

er

spe

cie

s O

the

r sp

ec

ies

11

42

61

b

hc

b

lO.O

(a)

btg

r 5

.62

(a)

bu

dg

4

.22

--

--

--

cc

ro

13

.3(a

,d,e

) m

do

v

17

.8(a

) .

..

.

11

59

02

rb

qu

0

.23

7(b

) .

..

..

1187

52

--

--

--

+

1.0

0

--

--

12

01

27

--

--

--

+

1

.00

--

--

13

01

54

--

--

--

0

.82

4

--

--

13

30

62

e

cru

+

1

00

--

--

0

.82

4

--

--

13

72

68

--

--

--

0

.56

2

cg

ra

0.5

62

c

otq

+

1

.00

..

..

c

wa

x

0.3

65

rn

ph

0

.08

3

..

..

st

ar

0.0

85

13

73

04

--

--

--

0

.65

0

--

--

14

16

62

rb

qu

1

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(b)

..

..

.

14

91

55

--

--

--

0

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0

--

--

29

80

22

.

..

.

cg

ra

1.0

0

29

80

44

.

..

.

eg

ra

+

1.0

0

33

06

43

--

--

--

0

.48

7(h

) --

--

43

84

15

b

hc

b

+

56

.2

..

..

.

43

91

45

c

cro

+

1

00

m

do

v

+

10

0

wc

sp

+

lO0

(e)

--

--

--

44

01

75

--

--

--

0

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2

cg

ra

0.5

62

--

47

09

06

b

hc

b

13

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gc

sp

17

8

..

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48

02

24

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--

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0

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8

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-

-

50

02

87

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--

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0

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4

--

--

50

42

45

a

ke

s 5

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(1)

bb

gr

10

.0(1

) b

bm

p

2.3

7(1

) --

--

--

bh

cb

4

.22

(a,1

) b

rcb

3

.16

(a,1

) b

tgr

2.3

7-3

.16

(a,1

) --

--

--

btp

a

10

.0(1

) b

ud

g

5.6

2(1

) c

cro

2

.37

(a,1

) --

--

--

dic

l 1

0.0

(1)

ge

sp

5.6

2(1

) g

osp

2

.37

-2.7

4(n

) --

--

--

grj

a

-10

.0(1

) m

do

v

8.1

0-8

.50

(a,1

) m

pa

r 1

2.0

(1)

--

--

--

mw

ea

4

.22

-4.8

7(n

) o

fpa

1

2.0

(1)

rbis

1

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-2.3

7(n

) --

--

--

rbq

u

5.6

2(b

,1)

rbse

-

7.2

0(1

) rd

go

-

25

.0(1

) --

--

--

rob

i 4

.22

(1)

sdo

v

+

4.0

0(1

) sh

cb

-

1.0

0(1

) --

--

--

tcb

b

4.2

2(1

) v

we

a

1.7

8-4

.22

(n)

wc

sp

5.6

2(a

,1)

--

--

--

ww

do

1

3.3

(a,1

) y

bm

p

2.3

7(1

) .

..

.

62

95

05

--

--

--

+

1

.00

--

--

67

10

45

c

cro

7

.50

(a)

md

ov

3

2.0

.

..

.

67

20

60

--

--

--

0

.65

0(h

) --

--

81

49

15

--

--

--

+

1

.00

--

--

94

70

24

rb

qu

1

.78

(b)

..

..

.

95

69

01

b

tgr

5.6

2(a

) c

cro

2

37

(e)

cg

oo

+

5

6.2

(a,e

) 0

.20

0

--

--

md

ov

5

6.2

-75

.0(a

,e)

ww

do

3

1.6

-13

3(a

) .

..

.

13

05

62

0

--

--

--

0.2

00

--

--

13

14

41

6

--

--

--

+1

.00

--

--

13

14

84

7

tcb

b

75

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37

.

..

..

13

28

53

6

--

--

--

+

1.0

0

_ _

13

29

86

8

cc

ro

+

10

0

wc

sp

+

10

0

--

--

__

_

_

13

71

39

1

--

--

--

0.6

81

_

_

__

:~

1461

229

--

--

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O. 1

80

_

_

__

15

63

66

2

bh

cb

1

.33

--

--

--

rb

qu

0

.42

2-0

.56

2

--

r

20

32

65

7

bh

cb

7

.50

(a,d

,h)

btg

r 4

.22

(a)

bu

dg

1

.33

0

.04

2(h

) b

hc

b

0.3

16

(h)

bw

qu

+

1.0

0

bw

qu

1

9.6

-

24

.0(a

) c

cro

7

.50

(a,d

) c

wa

x

5.6

2

--

eg

ra

0.0

56

(h)

cw

ax

0

.01

2

ed

ov

3

.16

g

csp

3

.16

g

osp

5

.62

(n)

--

go

sp

0.1

78

(n)

md

ov

-0

.50

0

hla

r 4

.22

id

ov

4

.22

(a)

md

ov

lO

.O(a

) --

m

we

a

0.0

76

(n)

rbis

O

. 13

3(n

) .

mw

ea

4

. 87

-

7.5

0(n

) w

wd

o

lO.O

(a)

rbis

5

.62

-7

.50

(n)

--

rbq

u

0.0

15

rn

ph

0

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2(h

)

rbq

u

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2-7

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(a,b

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she

r 2

3.7

tc

bb

5

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(h)

--

sta

r 0

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8

tcb

b

0.0

22

Page 27: The acute oral toxicity, repellency, and hazard potential of 998 … · 2014-12-03 · Abstract. The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one

va

lq

24

.0(h

) v

we

a

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0(n

) w

csp

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56

2(h

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21

04

64

5

bb

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5

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.

..

.

22

40

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v

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2

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88

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cc

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+

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6(h

) c

gra

-1

.00

(h)

52

21

42

1

btg

r 1

7.8

(a)

md

ov

2

3.7

(a)

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--

53

77

20

8

bu

dg

1

78

c

cro

+

1

00

(a)

md

ov

1

33

--

--

wc

sp

56

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,e)

..

..

5

39

24

05

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+

1.0

0

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59

02

52

3

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10

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60

12

92

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50

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69

23

22

4

rbq

u

1.3

3(b

) .

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.

71

49

79

3

bw

qu

1

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7

42

99

05

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_

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+ 1

.00

--

76

82

90

8

rbq

u

§ 2

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(b)

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77

04

34

9

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+ 1

.00

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77

45

89

3

ak

es

+

31

6(j

,k)

bb

mp

1

0.0

b

jay

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10

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) --

--

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wl

4.2

2

bu

dg

2

37

b

rth

-

3,1

6

--

--

btg

r 1

.00

b

wq

u

4. 2

2

bw

te

31

.6

--

--

cb

th

3. I

6

cc

ro

1.3

3-1

,78

(j)

cfin

+

1

00

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--

ch

ac

4

2.2

c

ba

w

56

20

) c

rav

5

s --

--

gd

ov

4

.22

g

ea

g

+

10

0

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sp

28

7-

31

6(n

) --

--

grj

a

5.6

2

md

ov

3

.16

-7.5

00

) m

we

a

+

31

6(n

) --

--

pin

d

+

31

.60

) rb

is

21

5-2

37

(n)

rbq

u

31

.6

--

--

rec

b

5.6

2

rob

i 3

.16

sc

rj

1.7

8

--

--

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b

2.7

4

turk

5

.62

v

alq

-

10

.0

--

--

vw

ea

+

3

16

(n)

wc

sp

+

32

0

wfd

o

+

5,6

2

--

--

ww

do

4

.22

.

..

.

77

80

33

8

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0.6

80

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01

85

2

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.00

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80

65

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3

rbq

u

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3(b

) .

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.

10

12

43

75

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~

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+ 1

.00

--

12

71

22

86

b

tgr

10

.0(a

) m

do

v

7.5

0(a

) w

fdo

4

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(a)

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--

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do

4

.21

(a)

..

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1

40

07

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5

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81

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07

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0

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00

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u

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20

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65

79

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b

+

10

0

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21

08

76

49

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b

+

10

0

..

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24

35

36

15

rb

qu

0

.75

0

..

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3

25

75

80

7

cc

ro

- 1

0.0

b

ud

g

23

,7

rob

i 1

,55

--

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scrj

I0

,0

..

..

35

33

56

05

b

hc

b

10

.0

bw

qu

1

.33

rb

qu

5

.62

(b)

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35

94

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31

b

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u

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6

cc

ro

4.2

2

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1

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ar

6. 3

5

..

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53

02

31

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0

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2

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37

84

13

31

m

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v

+

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0

..

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39

45

72

44

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2.3

7

bw

qu

5

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rb

qu

2

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(b)

--

--

39

45

72

55

b

hc

b

2.3

7

bw

qu

1

3.3

rb

qu

0

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0(b

) --

--

6

11

64

09

8

bh

cb

+

lO

0(h

) c

cro

+

lO

0(i

) tc

bb

+

lO

0(h

) 0

.23

7(h

,i)

bh

cb

0

.35

0(h

) v

alq

+

1O

O(h

) --

--

--

rn

ph

O

. 17

8(h

,i)

..

..

v

alq

O

. 17

8(h

,i)

vw

ga

rnp

h

bw

qu

rnp

h

cg

ra

- tc

bb

0.0

63

(n)

+ 1

.00

(h)

+1

.00

0,3

16

0,0

56

(h,i

)

0.0

32

(h,i

)

g ~Z

(1).

S

pe

cie

s c

od

es

are

id

en

tifi

ed

in

Ta

ble

1.

(2).

Le

tte

rs

in (

) i

nd

ica

te p

rev

iou

sly

p

ub

lish

ed

so

urc

es

for

da

ta p

rese

nte

d

as

foll

ow

s: (

a) S

ch

afe

r 1

97

2;

(b)

Sc

ha

fer

et a

l.

19

73

b;

(c)

Sc

ha

fer

et a

l.

19

79

; (d

) S

ch

afe

r et

al.

1

96

7;

(e)

Sc

ha

fer

et a

l.

19

72

; (f

) S

ch

afe

r et

al.

1

97

6;

(g)

Sc

ha

fer

et a

l.

19

77

; (h

) S

cb

afe

r et

al.

1

97

1;

(i)

Fra

nk

et

al.

1

97

0;

(j)

De

Cin

o

et a

l.

19

66

; (k

) S

ch

afe

r et

al,

1

96

9;

(1)

Sc

ha

fer

et a

l.

19

73

a; (

m)

Sc

ha

fer

et a

L

19

82

; (n

) S

he

fte

et

al.

1

98

2.

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382 E .W. Schafer, Jr., et al.

Acknowledgments. The authors wish to thank the following indi- viduals for assistance in collecting, typing, and editing the data contained in this publication; Trudie Abendroth, Lore Burbach, Donald Cunningham, Patrick Funderburg, Janet Garcia, Thomas Hall, David Hayes, Glenn Hood, Cecelia Nelson, and Barbara Recktenwald. The preparation and compilation of this data was supported, in part, through Interagency Agreement #14-16- 0009-81057 which was funded by the U.S. Environmental Pro- tection Agency.

References

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Frank, F. R., E. W. Schafer, Jr., and J. L. Guarino: Laboratory and field studies with an avian repellent for sprouting seeds. Proc. Bird Control Seminar 5, 86 (1970).

Friedman, M.: The use of ranks to avoid the assumption of nor- mality implicit in the analysis of variance. J. Amer. Star. Assoc. 32, 675 (1937).

Litchfield, J. T., and E. W. Wilcoxon: A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exptl. Therap. 96, 99 1949.

Schafer, E. W., Jr.: The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicol. Appl. Pharmacol. 21, 315 (1972).

Schafer, E. W., Jr., and R. B. Brunton: Chemicals as bird repel- l e n t s - t w o promising agents. J. Wildl. Manage. 35, 569 (1971).

Schafer, E. W., Jr., and D. J. Cunningham: An evaluation of 146 compounds as avian immobilizing agents. USDI Spec. Sci. Rept. Wildl. 150, Washington, DC (1972).

Schafer, E. W., Jr., R. B. Brunton, and D. J. Cunningham: A summary of the acute toxicity of 4-aminopyridine to birds and mammals. Toxicol Appl. Pharmacol. 26, 532 (1973a).

Schafer , E. W., Jr . , R . B . Brun ton , and N. F. Lockyer : Evaluation of 45 chemicals as chemosterilants in adult male coturnix. J. Reprod. Fert. 48, 371 (1976).

Schafer, E. W., Jr., R. B. Brunton, and N. F. Lockyer: Indi- cator bird species for toxicity determinations: Is the tech- nique useful in test method development? Vertebrate Pest

Control and Management Materials. ASTM STP 680 J. R. Beck (ed.). American Society for Testing and Materials, 157. Philadelphia, PA (1979).

Schafer, E. W. Jr., J. L. Guarino, and R. B. Brunton: Use of male coturnix quail in the laboratory development of avian chemosterilants. Vertebrate Pest Control and Management Materials. ASTM STP 625 W. B. Jackson and R. E. Marsh (eds.). American Society for Testing and Materials, 225. Philadelphia, PA (1977).

Schafer, E. W., Jr. , R. R., West, and D . J . Cunningham: DRC-1347-A new starling contact toxicant. Pest Control 37, 22 (1969).

Schafer, E. W., Jr., R. B. Brunton, N. F. Lockyer, and J. W. DeGrazio: Comparative toxicity of 17 pesticides to the quelea, house sparrow and red-winged blackbird. Toxicol. Appl. Pharmacol. 21, 154 (1973b).

Schafer, E. W. Jr., R. B. Brunton, E. C. Schafer, and J. Chevez: Effects of 77 chemicals on reproduction in male and female coturnix quail. Ecotoxicol. Environm. Safety 6, 149 (1982).

Schafer, E. W., Jr., R. I . Starr, D.J . Cunningham, and T. J. DeCino: Substituted phenyl N-methylcarbamates as tempo- rary immobilizing agents for birds. J. Agric. Food Chem. 15, 287 (1967).

Shefte, N., R. L. Bruggers, and E. W. Schafer, Jr.: RepeUency and toxicity of three bird control chemicals to four species of African grain-eating birds. J. Wildl. Manage. 41,453 (1982).

Snedecor, G. W., and W. G. Cochran: Statistical methods. 6 ed. Iowa State Univ. Press Ames, Iowa: (1971).

Starr, R . I . , J .F . Besser, and R. B. Brunton: A laboratory method for evaluating chemicals as bird repellents. J. Agric. Food Chem. 12, 342 (1964).

Thompson, W. R.: Use of moving averages and interpolation to estimate median effective dose. Bacteriol. Rev. 11, 115 (1948).

Thompson, W. R., and C. S. Weil: On the construction of tables for moving average interpolation. Biometrics 8, 51 (1952).

Weft, C. S.: Tables for convenient calculation of median effec- tive dose (LD~0 or EDs0) and instructions in their use. Biometrics 8, 249 (1952).

Manuscript received for publication July 10, 1982 and in revised form November 1, 1982.