BRANCHED CHAIN ~WRICHED AMINO ACID NUTRITION DOES NOT CHANGE THE OLWIL73MEOF HEPATIC COMA IN PATIENTS WITH CIRRHOSIS OF THE LIVER 337 H.Vilstrup, C.Gluud, F.Hardt, M.Kristensen, B.Mel~aard, O.K~hler, H.J.Sch~tten, J.J.Krintel, B.A.Hansen, A.Dejgaard, D.Bucher, Hvidovre Hospital, Bispebjerg Hospital, and Rigshospitalet, Copenhagen, Denmark Sixty-four patients with cirrhosis and hepatic encephalopathy (HE), on the average grade III for 3 days, were randomized to infusion for up to 14 days with either I g/(kg-day) of a- mino acids with 40% branched chain amino acids (BCAA) or isocaloric glucose, supplemented with 50% glucose to 30 kcal/(kg-day) and lactulose. The mean plasma a-amino-N concentration was 4.5 nmol/l and increased to 5.4 mmol/l in both groups during the infusions, in the BCAA group partly due to increase in the BCAA concentration. The regimens were well tolerated. The patients spent on the average 5 days in the regimens. In both groups 16 patients woke up and 11 patients died. The rest of the patients were considered as treatment failures because of renal or respiratory failure. The neurological status, scored daily by the "Glasgow Coma Scale", deteriorated in 10 of the 11 glucose treated deaths, and in 3 of the 11 BCAA treated deaths (p<0.01). Thus BCAA do not change the outo0me of acute HE in cirrhotics, which pre- sumably depends on the degree of liver impairment, but may exert a cerebroprotective effect. TERLIPRESSIN IN BLEEDING ESOPHAGEAL VARICES 338 S.Walker, A.Stiehl, R.Raedsch, B.Kommerell Med. Univ. Clinic, D-6900 Heidelberg, FRG A double blind placebo controlled study was performed to establish whether the clinical cource of variceal hemorrhage can be improved by the addition of terlipressin (Na-triglycyl-8-1ysine-vasopressin)to standard therapy. Fifty bleeding episodes from esophageal varices in 34 patients were randomized. Standard therapy with transfusions, fluid and electrolyte correction and laotulose was performed in both groups. Balloon tamponade-was used in 20 bleeding episodes in the terlipressin group and in 19 bleeding bleeding episodes in the control group. Sclerotherapy was performed in five bleeding episodes in the terlipressin group and in sev, en bleeding episodes in the placebo group. In the terlipressin group, hemorrhage was controlled in all bleeding episodes (25/25) whereas in the the placebo group only 20 of 25 bleeding episodes could be stopped within 36 hours (p=O.05). All 16 bleeding episodes treated with terlipressin plus balloon tamponade but only 9 of 14 bleeding episodes treated with placebo plus balloon tamponade could be stopped (p=O.01). The hos'pital mortality rate was 12% (3/25) in the terlipressin group and 32% (8/25) in the control group. Patients in the terlipressin group required fewer transfusions, the balloon tamponade needed to be blocked for a shorter time and the duration of bleeding was shorter than in the control group. However these differences were not signifloant. We conclude that the.addition of terlipressin to standard therapy raises the rate of control of acute variceal hemorrage. $347

Terlipressin in bleeding esophageal varices

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Page 1: Terlipressin in bleeding esophageal varices

BRANCHED CHAIN ~WRICHED AMINO ACID NUTRITION DOES NOT CHANGE THE OLWIL73ME OF HEPATIC COMA IN PATIENTS WITH CIRRHOSIS OF THE LIVER

337 H.Vilstrup, C.Gluud, F.Hardt, M.Kristensen, B.Mel~aard, O.K~hler, H.J.Sch~tten, J.J.Krintel, B.A.Hansen, A.Dejgaard, D.Bucher, Hvidovre Hospital, Bispebjerg Hospital, and Rigshospitalet, Copenhagen, Denmark

Sixty-four patients with cirrhosis and hepatic encephalopathy (HE), on the average grade III for 3 days, were randomized to infusion for up to 14 days with either I g/(kg-day) of a- mino acids with 40% branched chain amino acids (BCAA) or isocaloric glucose, supplemented with 50% glucose to 30 kcal/(kg-day) and lactulose. The mean plasma a-amino-N concentration was 4.5 nmol/l and increased to 5.4 mmol/l in both groups during the infusions, in the BCAA group partly due to increase in the BCAA concentration. The regimens were well tolerated. The patients spent on the average 5 days in the regimens. In both groups 16 patients woke up and 11 patients died. The rest of the patients were considered as treatment failures because of renal or respiratory failure. The neurological status, scored daily by the "Glasgow Coma Scale", deteriorated in 10 of the 11 glucose treated deaths, and in 3 of the 11 BCAA treated deaths (p<0.01). Thus BCAA do not change the outo0me of acute HE in cirrhotics, which pre- sumably depends on the degree of liver impairment, but may exert a cerebroprotective effect.

TERLIPRESSIN IN BLEEDING ESOPHAGEAL VARICES

338 S.Walker, A .St ieh l , R.Raedsch, B.Kommerell

Med. Univ. C l i n i c , D-6900 Heidelberg, FRG

A double b l ind placebo cont ro l led study was performed to establ ish whether the c l i n i c a l cource of var iceal hemorrhage can be improved by the addi t ion of t e r l i p r e s s i n (Na- t r ig lycy l -8-1ys ine-vasopress in) to standard therapy. F i f t y bleeding episodes from esophageal varices in 34 pat ients were randomized. Standard therapy with transfusions, f l u i d and e l e c t r o l y t e correct ion and laotu lose was performed in both groups. Balloon tamponade-was used in 20 bleeding episodes in the t e r l i p r e s s i n group and in 19 bleeding bleeding episodes in the control group. Sclerotherapy was performed in f i ve bleeding episodes in the t e r l i p r e s s i n group and in sev, en bleeding episodes in the placebo group. In the t e r l i p r e s s i n group, hemorrhage was cont ro l led in a l l bleeding episodes (25/25) whereas in the the placebo group only 20 of 25 bleeding episodes could be stopped within 36 hours (p=O.05). A l l 16 bleeding episodes treated with t e r l i p r e s s i n plus balloon tamponade but only 9 of 14 bleeding episodes treated with placebo plus bal loon tamponade could be stopped (p=O.01). The hos'pital mor ta l i t y rate was 12% (3/25) in the t e r l i p r e s s i n group and 32% (8/25) in the control group. Patients in the t e r l i p r e s s i n group required fewer transfusions, the balloon tamponade needed to be blocked for a shorter time and the duration of bleeding was shorter than in the contro l group. However these di f ferences were not s i g n i f l o a n t . We conclude that the .add i t ion of t e r l i p r e s s i n to standard therapy raises the rate of control of acute var iceal hemorrage.

$347