technologies and services - .NET Framework

www.innovabiosciences.com +44 (0) 1223 [email protected]

Bioconjugation technologies and services

www.innovabiosciences.com 2 3

Contents

Antibody and protein labeling - Lightning-Link®

Oligonucleotide labeling kits - Thunder-Link® PLUS

Gold nanoparticle conjugation kits - InnovaCoat® GOLD

Colloidal gold

Pre-conjugated gold nanoparticles

LATEX conjugation kits

ATPase & GTPase assay kitsPhopshate detection reagents

B.I.T.S.® Immunoassay kits

Antibody conjugates

Purification kits and accessory products

Custom services

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26

+44 (0) 1223 [email protected]

About us

Innova Biosciences are world leading experts in easy-to-use, cutting-edge bioconjugation technologies and services. We have the flexibility to support scientists from academia through to commercial manufacturing, developing and supplying reagent products to make science easier, both off-the shelf and to customer specification.

Our products are based on our antibody and protein labeling, nanoparticle, oligonucleotide labeling, and phosphate detection enzyme activity assay technologies.

All of our product ranges are of the highest quality and are designed to streamline R&D and manufacturing processes, whilst also reducing overall project costs by cutting costs associated with e.g. material waste, in-house equipment, and staff time, providing increased return on investment compared to traditional methods.

Our ever expanding portfolio, including the Lightning-Link®, InnovaCoat® and Thunder-Link® brands, is available to research laboratories, pharmaceutical, biotechnology and diagnostic companies worldwide.

USA and Canada +1 855-466-6821UK and rest of world +44 (0) 1223 661 000Email [email protected]


Lightning-Link® is the world’s fastest, easiest to use and most efficient antibody conjugation method, offering antibody and protein labeling with only 30 seconds hands-on time and no separation steps.

30 seconds hands-on time

100% antibody recovery

Over 40 available labels using same chemistry

Fully scalable from µg to grams

We’ve been really impressed with Innova’s products. Their biotin kit is simple to use and proved more durable than many competitors’ kits, and we’ve seen significant improvements in reproducibility since we started to use them regularly. We’re looking forward to continuing to work with the Lightning–Link® technology.

Dr Jake Micallef, CSO of VolitionRx

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Antibody and protein labelingLightning-Link®

The Lightning-Link® conjugation process


Enzyme labeling kits Product code

Lightning-Link® Alkaline Phosphatase (AP) 702-0030

Lightning-Link® Glucose Oxidase 706-0030

Lightning-Link® Horseradish Peroxidase (HRP) 701-0030

Biotin/Streptavidin labeling kits Product code

Lightning-Link® Biotin A, Biotin B* 704-0030, 715-0030

Lightning-Link® Rapid Biotin A, Biotin B* 370-0030, 371-0010

Lightning-Link® Avidin 717-0030

Lightning-Link® Streptavidin 708-0030

Fluorescent Label Lightning-Link product code

Maximal Absorbance (nm)

Excitation colour

SuggestedExcitation Laser

Line (nm)

Maximal Emission (nm)

Emission Color

AMCA 313-0030 352 N/A 355 452

DyLight® 350 320-0030 354 N/A 355 432

Atto 390 349-0030 388 405 468

DyLight® 405 321-0030 402 405 428

PerCP 718-0030** 484 488 678

PerCP/Cy5.5 763-0030** 484 488 692

DyLight® 488 322-0030 496 488 524

Fluorescein 310-0030707-0030** 498 488 532

R-Phycoerythrin 703-0030** 498, 544, 566† 488, 532, 561 580

PE/Texas Red® 767-0030** 498, 544, 566† 488, 532, 561 618

PE/Atto594 768-0030** 498, 544, 566† 488, 532, 561 632

PE/Cy5 760-0030** 498, 544, 566† 488, 532, 561 672

PE/Cy5.5 761-0030** 498, 544, 566† 488, 532, 561 700

PE/Cy7 762-0030** 498, 544, 566† 488, 532, 561 782

Atto488 350-0030 504 488 530

B-Phycoerythrin 716-0005** 546 561 580

Cyanine Dye 3 340-0030 552 561 576

Rhodamine 311-0030 555 561 588

DyLight® 550 323-0030 556 561 584

Atto 565 351-0030 570 561 598

FluoProbes594 361-0030 594 561* 630

DyLight® 594 324-0030 594 561* 629

Texas Red® 315-0030 596 561* 616

DyLight® 633 325-0030 628 633, 635, 640 660

Atto 633 353-0030 634 633, 635, 640 660

FluoProbes647H 362-0030 650 633, 635, 640 684

Cyanine Dye 5 342-0030 652 633, 635, 640 678

Allophycocyanin 705-0005** 652 633, 635, 640 666

APC/Cy5.5 764-0030** 652 633, 635, 640 700

APC/Cy7 765-0030** 652 633, 635, 640 790

DyLight® 650 326-0030 656 633, 635, 640 686

Cyanine Dye 5.5 343-0030 680 640* 705

DyLight® 680 327-0030 686 640* 716

Atto700 354-0030 704 640* 724

DyLight® 755 328-0030 756 640* 794

DyLight® 800 329-0030 776 640* 798

† (R-)PE has three maxima, and all can be used. The optimal will depend on the application.* This Laser Line is some distance from the Maximal Absorbance, so performance will be compromised if this dye is used with the suggested Laser Line.** These kits require a 3 hour incubation time (instead of 15 minutes).

Antibody & protein labeling

* Biotin A - intended for assays in which a streptavidin-labeled detection reagent will be used. Biotin B - optimised for assays in which the biotinylated protein is captured by streptavidin immobilized on a surface.


Alkaline Phosphatase anti-Human IgG (Fc) Conjugates analysed by ELISA

Anti-human IgG monoclonal antibody was purchased pre-conjugated to alkaline phosphatase from a commercial supplier. The same antibody was purchased in un-conjugated form and then conjugated to alkaline phosphatase using a Lightning-Link® kit.The Lightning-Link® conjugate demonstrates enhanced titre and sensitivity.

ELISA data Direct vs indirect labeling

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Immunohistochemistry dataDual staining using Lightning-Link conjugates

Dual staining of CD3 and CD20 with antibodies directly conjugated using Lightning-Link kits. Mouse anti-human CD3 was conjugated with alkaline phosphatase, and mouse anti-human CD20 was conjugated using HRP. Both antibodies were used simultaneously to stain formalin-fixed, paraffin embedded human lymph node. CD20 positive cells are visualised using DAB (Brown) and CD3 cells with Fast Red (Red).

Direct labeling of monoclonal antibodies enables straightforward dual-color staining in IHC, which is otherwise a highly complex and time-consuming technique.


Flow cytometry dataLightning-Link® vs ready conjugated antibody

Western blot dataDirect vs indirect labeling

Lightning-Link® Ready conjugated antibodyRPA-T4 clone for human CD4, conjugated to RPE

RPA-T4 clone for human CD4, conjugated to FITC RPA-T4 clone for human CD4, conjugated to FITC

Mouse monoclonal antibodies specific for human cell surface markers were purchased from a commercial source in both unconjugated and ready conjugated formats. The unconjugated antibodies were linked to R-PE or FITC using a Lightning-Link® kit, and the conjugates were compared in flow cytometry staining of human peripheral blood lymphocytes. The blue curve shows unstained cells.

RPA-T4 clone for human CD4, conjugated to RPE

Antibody & protein labeling

Primary antibody directly conjugated to HRP using Lightning-Link® shows enhanced sensitivity in western blotting compared to the traditional indirect technique.


The Thunder-Link® PLUS oligonucleotide conjugation kit enables the simple and rapid conjugation of antibodies to oligonucleotides. The kit is quick and easy to use, overcoming time consuming and lengthy protocols associated with standard conjugation methods.

Any oligo sequence may be used

Fast oligo conjugation - only 1 hour!

High antibody and oligo recovery

Robust and flexible clean-up procedure

Works with antibody fragments and other proteins

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Oligonucleotide Labeling Kits Thunder-Link® PLUS

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Products Product code

3 reaction + control (a single reaction to conjugate 100µg antibody) 425-0300

1 reaction + control (each reaction to conjugate 100µg antibody) 425-0000


Oligonucleotide Labeling Kits Thunder-Link® PLUS

The Thunder-Link® PLUS conjugation process

Oligonucleotide conjugationCustom services

From finding the best performing conjugate for your specific assay through to generating your optimised conjugates at your required scale and ratio, our experienced conjugation scientists can help.

See page 26 for more information on our custom antibody- oligo micro-optimisation and custom conjugation services.


InnovaCoat® GOLD is a one-step gold nanoparticle conjugation kit for antibodies, proteins and peptides or any other biomolecule with an amine group. It allows easy conjugation of gold nanoparticles for use in R&D applications and for the development and manufacturing of diagnostic kits.

Proprietary surface coat

Ultra-stable

Potential enhanced assay sensitivity

Covalently link antibodies and analytes

Different surface chemistries

The InnovaCoat® GOLD process

Having made our own passively adsorbed antibody-coated gold colloid for some years then more recently moving to a high OD, no-spin method, we were a little reluctant to try out another method quite so soon. However the extreme simplicity and rapidity of the InnovaCoat® GOLD covalent conjugation, combined with the excellent functionality and consistency of the final product greatly helped us make the change. We now use less colloid per test in a demanding, room temperature stored, liquid formulation and are finding the development of new rapid tests to be significantly easier.

Phil Goodwin, UK Biotechnology Professional

Gold Nanoparticle Conjugation Kits InnovaCoat® GOLD

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InnovaCoat® GOLD has a unique surface coat that completely shields the metallic core of the nanoparticle from the external environment, eliminating colloidal instability.

2nm InnovaCoat® surface

40nm particle

Gold nanoparticle conjugation

Gold Nanoparticle Conjugation Kits InnovaCoat® GOLD

Size

10nm 20nm 40nm 60nm 80nm

Target Group

Prod

uct

InnovaCoat® GOLD ● ● ● ● ● Amine

InnovaCoat® GOLD Maleimide ● ● Thiol

InnovaCoat® GOLD Hydrazide ● Aldehyde

Com

mon

App

licati

ons Lateral Flow Assay

Scanning EM

Western Blot

Transmission EM

DLS

Light Microscopy

Dot Blot

FRET

Flow Cytometry

Dynamic Force Microscopy


Antibody conjugation using InnovaCoat® GOLD vs traditional passive conjugation techniques with uncoated gold nanoparticles, showing both enhanced signal intensity and improved specificity. 40nm gold particles were labeled with anti-IgA antibody, and used to measure IgA concentration in a lateral flow inhibition assay, with IgA bound to a lateral flow strip.

The graph shows a comparison of test and control line signal intensities between biotin conjugated gold nanoparticles from Competitor 1 or 2 and covalently conjugated InnovaCoat® GOLD-Biotin on lateral flow test strips.

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Lateral flow data InnovaCoat® GOLD vs traditional techniques


InnovaCoat® GOLD alternative chemistriesAs the InnovaCoat surface is firmly anchored to the gold nanoparticle and is resistant to extreme conditions, it is therefore very easy to introduce derivatives of the main technology.

Standard Labeling InnovaCoat® GOLDStandard Labeling InnovaCoat® GOLD

InnovaCoat® GOLD Hydrazide InnovaCoat® GOLD Maleimide Gold nanoparticle conjugation

Optimization services & kitsWe can quickly develop multiple antibody conjugates using a range of proprietary methods. InnovaCoat GOLD kits are also available if you wish to carry out your own rapid screening of panels of antibodies.We can further optimize conjugates using an extended collection of non-catalogue materials and other chemistries if required, and carry out preliminary testing of conjugates.

Custom coating servicesWe appreciate that you may like to benefit from a simplified production process using a one-step covalent approach but still use your own gold nanoparticles.We have tested a broad range of gold nanoparticles and have successfully applied the InnovaCoat surface in every case.


Colloidal goldUltra high quality gold nanoparticles

Our gold nanoparticles have been rigorously tested against market-leading brands and shown to be superior. These gold nanoparticles boast many benefits including:

Uniform spherical shape

Narrow size distribution

Ultra high quality

Batch-to-batch consistency

Available at high concentrations to simplify assay development

Available in bulk quantities

Products Concentration

1OD 10OD 15OD 20OD

10nm 20ml ● ●100ml ● ●

40nm10ml ● ● ● ●

100ml ● ● ● ●

Our ultra-high quality colloidal gold is currently available in 10nm and 40nm sizes in the concentrations shown below.

10nm 40nm

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Pre-conjugated gold nanoparticlesInnovaCoat® GOLD Conjugates

Our pre-conjugated gold nanoparticles are manufactured using our InnovaCoat® GOLD nanoparticles which have a proprietary surface coat that covalently bind the detection protein providing highly stable conjugates.

Products 10nm 20nm 40nm 80nm Target group

InnovaCoat® GOLD Streptavidin ● ● Biotin

InnovaCoat® GOLD Biotin ● Streptavidin

InnovaCoat® GOLD Goat Anti-Mouse ● ● ● ● Mouse IgG

InnovaCoat® GOLD Goat Anti-Rabbit ● ● ● ● Rabbit IgG

InnovaCoat® GOLD Protein A ● ● IgG

InnovaCoat® GOLD Protein G ● ● IgG

For large quantities of InnovaCoat® GOLD conjugates or colloidal gold please contact us for pricing:

e: [email protected]

t: +44 (0) 1223 661000

Gold nanoparticle conjugates


LATEX conjugation kits

Our LATEX bead conjugation kit is a one-step kit for covalently conjugating antibodies, proteins and peptides (or any other biomolecule with an amine group) to specially treated latex beads without the need for extensive optimisation.

Quick and easy to use - conjugates ready to use in 35 minutes

Our latex is specially treated and resistant to aggregation

No extensive pH optimisations required!

The LATEX conjugation kit process

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Figure 3. Multiplexed Latex. The three colors of latex each conjugated to a different antibody or protein and forming a line either by a direct binding event (red and black latex) or a sandwich assay binding event (blue latex). The three colors of latex demonstrate no aggregation or background staining.

Figure 2. Lateral Flow Assay of our specially-treated latex conjugated to the monoclonal anti-CRP antibody (mAb 2) titrated against CRP in buffer or CRP spiked CRP-depleted serum (100 % serum). The latex behaves similarly in serum and buffer, and no aggregation or non-specific binding is seen.

Products 1 reaction Midi kit

4 reaction Mini kit

10 reaction Mini kit

LATEX Conjugation Kit - Blue 400nm 1000-0120 1000-0040 1000-0100

LATEX Conjugation Kit - Red 400nm 1002-0120 1002-0040 1002-0100

LATEX Conjugation Kit - Black 400nm 1004-0120 1004-0040 1004-0100

Latex Bead Conjugation

Figure 1. Lateral Flow Assay of our specially-treated latex beads conjugated to a monoclonal anti-CRP antibody (mAb 1) titrated against CRP. 2 ng/ml CRP can easily be detected.

Lateral flow data


At the heart of this range of assay kits is PiColorLockTM, a universal phosphate detection reagent for all phosphate-generating enzymes which forms colored complexes that are stable for hours.

Colorimetric (non-radioactive) assay

Special additives ensure complete suppression of non-enzymatic backgrounds with acid-labile substrates(e.g. ATP, GTP)

Ultra stable phosphate-dye complexes which last for hours

Compatible with almost any assay buffer

Compatible with multiple enzyme targets in drug discovery

Long shelf life

ATPase and GTPase assay kitsPhosphate detection reagents

Competitor assays suffer from several problems including reagent precipitation. PiColorLock™ ensures high stability of the colored dye-phosphate complexes (green color).

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PiColorLock™ has been designed to have a large linear range, thus reducing the need for sample dilution. Competitors’ products are linear over a much narrower range of concentrations.

Lyophilized ATP & GTP vials Product: ATP 601-9999 GTP 602-9999Ultra high quality ATP and GTP to ensure the lowest possible assay background. Just reconstitute by adding water, avoid multiple freeze-thaw cycles to ensure high performance ATP and GTP in your assay.

PiColorLock detection reagent Product: 303-0030PiColorLock is a phosphate detection reagent for measuring phosphatases, ATPases, GTPases and other enzymes that release inorganic phosphate (Pi). The reagent comes with with an Accelerator, Stabiliser and Pi Standard ideal for high throughput screening.

ATPase and GTPase Assay kits Product: 601-0120, 602-0120These non-radioactive colorimetric assay kits use a 96 well format. All the necessary reagents are supplied for measuring enzyme activity. 2 and 5 plate kits available.

ATPase & GTPase assay kits

PiBind™ resin Product: 501-0015PiBind™ resin provides a remarkably quick and easy way to remove contaminating Pi from buffers therefore reducing high assay backgrounds. The resin works over a broad range of pH values and is unaffected by many commonly used buffer additives.

Products

Competitor CPiColorLock PiColorLock

Competitor ACompetitor B

ATP has been incubated in three phosphate detection reagents. A steadily rising non-enzymatic background signal is seen with competitor reagents, whereas PiColorLock™ gives baseline readings.


B.I.T.S. Immunoassay Kits

We have teamed up with Mologic, a specialist diagnostic development company, to offer a range of high-quality immunoassay kits.

The B.I.T.S.® ELISA and lateral flow kits are easy to use and provide fast, accurate, and high quality immunoassays which require no sample preparation.

They contain everything required for ELISA and lateral flow assays, including high quality, stable enzyme or gold conjugates, produced using our world-leading conjugation technology.

Developed by Mologic in partnership with Innova Biosciences

Imm

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Reliable, rigorously validated assays

Competitively priced without compromising on quality

Batch-to-batch reproducibility

Speed of assays allows you time to do more research

Simple procedure minimises operator error


Coming soon...

The B.I.T.S.® assay range currently focuses on inflammatory biomarkers.The first products launched are the Desmosine ELISA Kit, fMLP ELISA Kit, and the Human A1AT Lateral Flow Kit, with more kits due for release soon.

The unique B.I.T.S.TM desmosine ELISA kit has been developed to provide assays of desmosine in urine.

Desmosine ELISA kit*

The B.I.T.S.TM Lateral Flow kit for Human Alpha-1 antitrypsin (A1AT) provides fast, accurate assays of A1AT in plasma and urine.

Human A1AT Lateral Flow kit*

The B.I.T.S.TM fMLP ELISA kit provides fast, accurate results for levels of fMLP in human urine, with a 1.5 hour assay time.

fMLP ELISA kit*

Im

munoassay kits

*Kits are for research use only

ELISA Kits• PLA2G1B • A1AT (Alpha-1-antitrypsin)• HNE (Human neutrophil elastase)• Adiponectin• Leptin• CRP• Procalcitonin• MMP8• TNFa• Fibrinogen• TIMP1• TIMP2• IL6

Lateral Flow Kits• TIMP1 • TIMP2• Cystatin C• Adiponectin• Leptin


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The availability of antibodies directly conjugated to the enzyme or fluorescent dye of choice remains limited in many areas.

We have developed our antibody conjugation technology to offer a range of biomarker-specific antibodies conjugated to any one of our 20 different labels, each generated using our well established Lightning-Link® technology to ensure optimum conjugation performance.

All of our antibody conjugates are mouse anti-human, are stored at 4°C, shipped at room temperature and have a shelf life of 12 months (6 months for tandem labels).

Visit our website or ask us for our antibody conjugate catalogue to view our extensive library of cardiac biomarkers.

Antibody conjugates


The full list of specificities covered by the Innova cardiac marker panel is shown below. In each case multiple antibody clones are available – please enquire for further details.

Antibody

Adiponectin

Albumin

BNP

NT-proBNP

Calcitonin

CD40 ligand (CD40L)

CRP

Cystatin-C

D dimer

Fatty acid binding protein

GPBB

IGFBP-4

KIM

Lectin-like oxidized LDL receptor 1 (LOX-1)

Myeloperoxidase (MPO)

Myoglobin

PAPP-A dimer

PAPP-A

Procalcitonin

Retinol Binding Protein 4

S100 beta

Serum amyloid A

Troponin C

Troponin Complex

Troponin I - dephosphorylated

Troponin I - phosphorylated

Troponin I

Troponin T

Label

Unconjugated

InnovaCoat® GOLD

HRP

Alkaline Phosphatase

Glucose Oxidase

Biotin

Atto 390

Fluorescein

Atto488

PerCP

PerCP/Cy5.5

RPE

RPE-Cy5

RPE-Cy7

Rhodamine

Cy3

Atto565

Cy5

Texas Red

Atto633

APC

APC/Cy5.5

APC/Cy7

Atto700

Antibody conjugates

Antibody conjugates


Acce

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Purification kits and affinity resinsCommercially available antibodies often contain substances (e.g. BSA, glycine, tris, and azide) that interfere with labeling reactions.

We have developed a range of purification kits which allow for easy and rapid purification of antibodies from any buffer formulation for use with our Lightning-Link®, InnovaCoat® and LATEX conjugation kits.

The range also includes products for antibody purification from tissue culture supernatant (TCS), serum and ascites fluid; for concentration of antibodies and proteins; and for performing buffer exchanges.

Purified antibody compatible with our conjugation kits (no dialysis required)

Multiple species including mouse and rat specific kits

High recovery ( ̃80-90%)

Easy-to-use

All components included

Scale-up available

9 Concentrate antibodies and other proteins 9 Exchange your buffer (pH, salt concentration) 9 Remove non-protein additives including:

» BSA » Sodium Azide » Gelatin » Glycine » Tris

Our range of purification kits can be used to:


Maleimide Activated Labels, Thiolation KitsFor those who have molecules with thiol groups, our ultra-stable freeze-dried maleimide activated labels are designed to facilitate the production of conjugates.

To complement this range, our Thiolation Kits allow thiols to be introduced easily into proteins and other biomolecules. Our stabilised thiol detection reagent allows the successful introduction of thiols (or presence of thiols) to be confirmed and quantified prior to conjugation with a maleimide activated label.

Immunogen KitsOur Imm-LinkTM immunogen kits allow the conjugation of your hapten to BSA, KLH or Ovalbumin. Simply add a solution of the hapten to a lyophilised mixure containing the carrier protein and the required conjugation chemistry.There are 3 different chemistries available - carboxyl, sulfhydryl and amine - perfect for preparing antigens for immunization.

Accessory products

Secondary reagentsOur high-quality, stable streptavidin, protein A and biotin conjugates complement our range of labeling technologies and provide researchers with even more flexibility and choice of detection methods for their immunoassay.

Our streptavidin and protein A conjugates are produced using our unique Lightning-Link® bioconjugation technology, therefore providing high quality, stable conjugates for use in your application.


Conjugation servicesOur conjugation service is performed by in-house conjugation experts, providing you with the required antibody conjugate or antibody-oligo conjugate at your agreed conjugation ratio and scale.

What’s included?Generation of conjugate at required scale

Antibody clean-up prior to conjugation (removal of BSA or azide)

Antibody buffer exchanged in to a ‘conjugation friendly’ buffer if required

Evidence of successful conjugation provided

Custom Services

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Micro-optimisation servicesFind the best performing conjugate for your specific assay!

Optimising your antibody conjugates can be time consuming and difficult and can require significant amounts of antibody and label.

Our antibody and oligo micro-optimisation services provide a fast and efficient way to optimise your antibody or oligo conjugates using very small quantities of your antibody.

A choice of 3 different scales of conjugate 50ug, 100ug and 500ug

Over 30 different labels available

Antibody clean-up prior to conjugation

Evidence of successful conjugation provided

Scalable

Fast turnaround time

Full technical support


Bulk ordersInnova Biosciences can supply almost all its catalogue products in quantities that will fit your own research and manufacturing needs. Our bulk products have the same high level of performance and quality as our standard catalogue products only on a larger scale. Bulk orders can be provided in a format that best suits your needs.

Custom Pack SizesWe are able to offer our customers the luxury of choosing their own pack size. Our highly skilled manufacturing team can provide you with your very own bespoke pack size. For example we can offer our standard Lightning-Link conjugation kits including unique formulations in almost any size you may require up to 100mg, ideal for those customers who need to perform large scale conjugations on a regular basis.

Inventory ControlWe can offer a batch validation and reservation service. Although all our products are manufactured to the highest possible standards and quality checked to stringent parameters, there are still customers that wish to avoid potential lot to lot variation. For these customers we offer our inventory control service. With this service we give you the opportunity to test different lots of our product and the option to reserve a specific batch of your choice.

Benefits of these services include:

• Quantities and pricing to suit your requirements• Packaging that best suits your needs• Fast turnaround time• High level of quality and performance• Reproducibility• Guaranteed supply• Full technical support

If you would like any more information about this service, or have any technical questions please contact us at [email protected].

Custom

services

Innova Biosciences products are sold for research purposes only, and our terms and conditions of sale include a limited use license to our Intellectual Property for internal research applications.Commercial use, such as use within manufacturing, re-sale to third parties, or incorporation into kits, requires a separate written agreement, conferring relevant additional rights, with Innova Biosciences.

Lightning-Link®, InnovaCoat® and Thunder-Link® are registered trademarks of Innova BiosciencesCy and CyDye are trademarks of GE HealthcareDyLight® is a registered trademark of Thermo Fisher Scientific Inc. and its subsidiariesFluoProbes® is a registered trademark of interchimTexas Red® is a registered trademark of Life Technologies Corporation

Innova Biosciences Ltd.Babraham Hall

BabrahamCambridge CB22 3AT

United Kingdom

US Toll Free: 855-466-6821t: +44 (0) 1223 661000

e: [email protected]: www.innovabiosciences.com

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