IV N e w P a t e n t s

alkyl group), NRR' (where R and R' are defined as herelnabove) or the group O(CH2)nN- R4R5(where n is an integer of value 1 to 5-and preferably 2 or 3)-, and R4 and R5, identical or different, each represent an atom of hydrogen, a lower alkyl group and may form with the nitrogen atom to which they are bonded a heterocychc group of 5 to 7 vertices capable of being substituted and of comprising one or more other heteroatoms such as N and O), (n) their geometrical isomers, and (Ill) their salts It also relates to its method of preparation and its use as pharmaceutical

4421747

I N F L A M M A T I O N - P R E V E N T I N G P H A R M A C E U T I C A L

C O M P O S I T I O N O F O R A L A D M I N I S T R A T I O N

Mlklos Ghyczy, Adorjan Erdos, Gunte Heldemann, Cologne, Federal Repubhc Of Ger- many assigned to A Nattermann & Cle GmbH

A novel pharmaceutical composition is pro- vlded which is suitable for the prevention of In- flammation and which comprises a non- steroidal inflammation-preventing compound (e g pyrazolones, sahcyhc acid derivatives, in- doles, lndanes, and phenylacetlc acid and an- thranlhc acid derivatives) and at least one phosphohpld

4421738

S U G A R - C O A T E D T A B L E T C O N T A I N I N G F A T - S O L U B L E

P H A R M A C E U T I C A L M A T E R I A L

Satoshl Yamaglwa, Yoshlo Taguchl, Masanorl Kayano, Isezakl, Japan assigned to Elsal Co Ltd

A sugar-coated tablet for medical use com- prising a core containing low-melting fat-soluble pharmaceutical material and a sugar coating layer on said core, which is characterized by the feature that at least one water-soluble cellulose ether coating film is present between the core and the sugar-coating layer

4420470

P E R C U T A N E O U S A B S O R P T I O N T Y P E P H A R M A C E U T I C A L

P R E P A R A T I O N O F I S O S O R B I D E D I N I T R A T E O R

P E N T A E R Y T H R I T O L T E T R A N I T R A T E I N P R E S S U R E -

S E N S I T I V E L A M I N A T E

Saburo Otsuka, Toshlyuk Yoshlkawa, Sholchl Tokuda, Yuuseke Ito, Ibarakl, Japan assigned to NlttO Electric Industrial Co Ltd, Toa Elyo L

A pharmaceutical preparation comprising a flexible backing and a base material provided thereon is described wherein the base material consists essentially of a polymer having a glass transition temperature of from -70 degrees C to - 10 degrees C and exhibiting pressure-sensitivity at room temperature, and lSOSOrblde dlnltrate or pentaerythrltol tetranltrate This pharma- ceutical preparation is apphed to the skin, and permits the active ingredient to be absorbed through the skin into the body at a constant rate, and gradually over a long period of time

4420092

T A M P E R - R E S I S T A N T P H A R M A C E U T I C A L V I A L A N D

C A P A S S E M B L Y

Sam Flnkelsteln assigned to MPL Inc

A pharmaceutical vial and cap assembly of the kind comprising an open-top vial covered by a cap with a depending peripheral skirt, the Inner surface of the cap skirt and the outer surface of the vial having complementary mating interlock elements that preclude manual removal of the cap, the cap Including an integral tear member, defined by one or more weakened junction lines, such that pulling away the tear member allows ready manual removal of the cap, the cap top in- cludes a fill hole that for filling the vial with the