Inpharma 1399 - 9 Aug 2003

■ Tacrolimus plus prednisolone improvedsymptoms associated with Satoyoshi syndrome,according to researchers from Japan. They report thecase of a 13-year-old girl with Satoyoshi syndromewho had painful intermittent muscle spasms thatinvolved all her extremities, as well as alopecia andamenorrhoea. Baclofen and IV immunoglobulintherapy was unsuccessful. Treatment with tacrolimus3 mg/day and prednisolone 30mg on alternate dayswas initiated after three days of treatment with IVmethylprednisolone 1000 mg/day. The severity of themuscle spasms decreased gradually over a 10-monthperiod and thickening of the patient’s hair wasnoticeable within 7 months. The patient also reportedregular menstruation at 4 months. The clinicalimprovement correlated with decreases in the serumlevels of antinuclear antibody, anti-acetylcholinereceptor antibody and serum immunoglobulin G.Endo K, et al. Improvement of Satoyoshi syndrome with tacrolimus andcorticosteroids. Neurology 60: 2014-2015, 24 Jun 2003 800907443

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Inpharma 9 Aug 2003 No. 13991173-8324/10/1399-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved