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Commentary 3223 Tomatoes, lysophosphatidic acid, and the small intestine: new pieces in the puzzle of apolipoprotein mimetic peptides?

A. T. Remaley

Thematic Review 3227 Thematic Review Series: High Density Lipoprotein Structure, Function, and Metabolism: High density lipoproteins

and endothelial functions: mechanistic insights and alterations in cardiovascular disease Meliana Riwanto and Ulf Landmesser

Review 3244 Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I

Olga Gursky , Martin K. Jones , Xiaohu Mei , Jere P. Segrest, and David Atkinson

Research Articles 3258 DHA attenuates postprandial hyperlipidemia via activating PPAR � in intestinal epithelial cells

Rino Kimura , Nobuyuki Takahashi , Shan Lin , Tsuyoshi Goto , Kaeko Murota , Rieko Nakata , Hiroyasu Inoue , and Teruo Kawada

3269 Adaptive responses by mouse fetus to a maternal HLE diet by downregulating SREBP1: a microarray- and bio-analytic-based study Huan-Ling Yu , Huang-Tai Miao , Li-Fang Gao , Li Li , Yuan-Di Xi , Shao-Ping Nie , and Rong Xiao

3281 Role of the hydrophobic and charged residues in the 218–226 region of apoA-I in the biogenesis of HDL Panagiotis Fotakis , Andreas K. Kateifi des , Christina Gkolfi nopoulou , Dimitra Georgiadou , Melissa Beck , Katharina Gründler , Angeliki Chroni , Efstratios Stratikos , Dimitris Kardassis , and Vassilis I. Zannis

3293 Signifi cance of the hydrophobic residues 225–230 of apoA-I for the biogenesis of HDL Panagiotis Fotakis , Ioanna Tiniakou , Andreas K. Kateifi des , Christina Gkolfi nopoulou , Angeliki Chroni , Efstratios Stratikos , Vassilis I. Zannis , and Dimitris Kardassis

3303 Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture Jacqueline A. Hawkins-Salsbury , Archana R. Parameswar , Xuntian Jiang , Paul H. Schlesinger , Ernesto Bongarzone , Daniel S. Ory , Alexei V. Demchenko , and Mark S. Sands

3312 1-O -acylceramides are natural components of human and mouse epidermis Mariona Rabionet , Aline Bayerle , Christian Marsching , Richard Jennemann , Hermann-Josef Gröne , Yildiz Yildiz , Dagmar Wachten , Walter Shaw , James A. Shayman , and Roger Sandhoff

3322 Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle Magdalene K. Montgomery , Brenna Osborne , Simon H. J. Brown , Lewin Small , Todd W. Mitchell , Gregory J. Cooney , and Nigel Turner

3334 A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders Zhong-Ze Fang , Rong-Rong He , Yun-Feng Cao , Naoki Tanaka , Changtao Jiang , Kristopher W. Krausz , Yunpeng Qi , Pei-Pei Dong , Chun-Zhi Ai , Xiao-Yu Sun , Mo Hong , Guang-Bo Ge , Frank J. Gonzalez , Xiao-Chi Ma , and Hong-Zhi Sun

COVER: Left panel: HDL from healthy subjects exerts direct endothelial, potentially anti-atherogenic effects, i.e., stimulation of anti-infl ammatory, anti-oxidative, anti-apoptotic, and anti-thrombotic mechanisms. In contrast, HDL from patients with coronary disease (right panel) may lose potential endothelial anti-atherosclerotic properties, which has been termed ‘HDL dysfunction’. (See Riwanto and Landmesser, p. 3227.)

The online version of this article contains supplemental material.

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Table of ContentsThis issue is available in electronic form at

http://www.jlr.org

Vol. 54, No. 12 December 2013

ii

3345 Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding Hong-mei Gu , Ayinuer Adijiang , Matthew Mah , and Da-wei Zhang

3358 Novel technique for generating macrophage foam cells for in vitro reverse cholesterol transport studies Bhaswati Sengupta , Chandrakala Aluganti Narasimhulu , and Sampath Parthasarathy

3373 A mechanism for suppression of the CDP-choline pathway during apoptosis Craig C. Morton , Adam J. Aitchison , Karsten Gehrig , and Neale D. Ridgway

3385 The dependence of lipid asymmetry upon polar headgroup structure Mijin Son and Erwin London

3394 The elevation of apoB in hypercholesterolemic patients is primarily attributed to the relative increase of apoB/Lp-PLA 2 Constantinos C. Tellis , Eliza Moutzouri , Moses Elisaf , Robert L. Wolfert , Alexandros D. Tselepis

3403 Transgenic 6F tomatoes act on the small intestine to prevent systemic infl ammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid Mohamad Navab , Greg Hough , Georgette M. Buga , Feng Su , Alan C. Wagner , David Meriwether , Arnab Chattopadhyay , Feng Gao , Victor Grijalva , Janet S. Danciger , Brian J. Van Lenten , Elin Org , Aldons J. Lusis , Calvin Pan , G. M. Anantharamaiah , Robin Farias-Eisner , Susan S. Smyth , Srinivasa T. Reddy , and Alan M. Fogelman

3419 Long-term live cell microscopy studies of lipid droplet fusion dynamics in adipocytes Christian Jüngst , Matthias Klein , and Andreas Zumbusch

3430 Suffi cient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages Jinyong Kim , Joon No Lee , James Ye , Rosy Hao , Russell DeBose-Boyd , and Jin Ye

3438 Trans -vaccenate is � 13-desaturated by FADS3 in rodents Vincent Rioux, Frédérique Pédrono, Hélène Blanchard, Cécile Duby, Nathalie Boulier-Monthéan, Laurence Bernard, Erwan Beauchamp, Daniel Catheline, and Philippe Legrand

3453 Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice Zuquan Zou , Sandrine Bellenger , Karen A. Massey , Anna Nicolaou , Audrey Geissler , Célia Bidu , Bernard Bonnotte , Anne-Sophie Pierre , Mélaine Minville-Walz , Michaël Rialland , John Seubert , Jing X. Kang , Laurent Lagrost , Michel Narce , and Jérôme Bellenger

3464 Infl uence of apolipoprotein A-I and apolipoprotein A-II availability on nascent HDL heterogeneity Eric T. Alexander and Michael C. Phillips

3471 Discovery of a linoleate 9 S -dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum Inga Hoffmann and Ernst H. Oliw

Patient-Oriented and Epidemiological Research 3481 Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis

Ilenia Minicocci, Sara Santini, Vito Cantisani, Nathan Stitziel, Sekar Kathiresan, Juan Antonio Arroyo, Gertrudis Martí, Livia Pisciotta, Davide Noto, Angelo B. Cefalù, Marianna Maranghi, Giancarlo Labbadia, Giovanni Pigna, Fabio Pannozzo, Fabrizio Ceci, Ester Ciociola, Stefano Bertolini, Sebastiano Calandra, Patrizia Tarugi, Maurizio Averna, and Marcello Arca

3491 CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients Stuart D. Horswell , Lee G. D. Fryer , Claire E. Hutchison , Dlear Zindrou , Helen E. Speedy , Margaret-M. Town , Emma J. Duncan , Rasheeta Sivapackianathan , Hetal N. Patel , Emma L. Jones , Adam Braithwaite , Max P. A. Salm , Claire K. Y. Neuwirth , Elizabeth Potter , Jonathan R. Anderson , Kenneth M. Taylor , Mary Seed , D. John Betteridge , Martin A. Crook , Anthony S. Wierzbicki , James Scott , Rossi P. Naoumova , and Carol C. Shoulders

3506 Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm Mercedes Camacho , Jaume Dilmé , David Solà-Villà , Cristina Rodríguez , Sergi Bellmunt , Laura Siguero , Sonia Alcolea , José-María Romero , José-Román Escudero , José Martínez-González , and Luis Vila

3516 Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis Rong Wen, Byron L. Lam, and Ziqiang Guan

Methods 3523 LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude

improvement in sensitivity James G. Bollinger , Gajendra Rohan , Martin Sadilek , and Michael H. Gelb

3531 High-throughput fl uorescence assay for membrane-protein interaction Hyunjin Kim , Hamid Samareh Afsari , and Wonhwa Cho

3539 Erratum

3540 Author Index

Calendar (online only)

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