June 2013 Volume 29, Number 6

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PRTW

Society Position Statement

644 Canadian Cardiovascular Society/Canadian Heart Rhythm Society JointPosition Statement on the Use ofRemote Monitoring for CardiovascularImplantable Electronic Device Follow-up

Raymond Yee, MD, (Chair), Atul Verma, MD, MarianneBeardsall, RN, Jennifer Fraser, RN, Francois Philippon, MD,and Derek V. Exner, MD

Special Article

652 Randomized Cluster Crossover Trialsfor Reliable, Efficient, ComparativeEffectiveness Testing: Design of thePrevention of Arrhythmia DeviceInfection Trial (PADIT)

Stuart J. Connolly, MD, Francois Philippon, MD, YvesLongtin, MD, Amparo Casanova, PhD, David H. Birnie, MD,Derek V. Exner, MD, Paul Dorian, MD, Ratika Prakash, MD,Marco Alings, MD, and Andrew D. Krahn, MD

ublication Mail Agreement 41536048eturn undeliverable Canadian addresses to:rans continental Printing, 737 Moray St,innipeg, MB R3J 3S9 Printed in Canada

On the Cover: Canadian contribution to global research bycardiovascular disease (CVD) category (1981-2010). (A) Canada’saverage contribution to global CVD research over a 20-year period.(B) Trend in Canadian contribution by CVD category. TheCanadian contribution shows strong upward trend and doublesbetween the periods 1981-1985 and 2006-2010. From the articleby Nguyen et al., pages 742-746 of this issue.

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Editorial

659 Transitioning Between EndothelinReceptor Blockers: Monitoring toEnsure a Smooth Transition

Nancy Luo, MD, and John J. Ryan, MB, BCh

662 Circulating Progenitor Cells asa Heart Failure Biomarker: Doesa Failing Marrow Predict a FailingHeart?

Everad L. Tilokee, BSc, and Darryl R. Davis, MD, FRCPC

Clinical Research - Heart Failure

664 Circulating Proangiogenic ProgenitorCells Independently Predict FunctionalCapacity in Heart Failure Patients

Ana C. Alba, MD, Spencer D. Lalonde, HBSc, Vivek Rao, MD,PhD, Stephen Walter, PhD, Gordon H. Guyatt, MD, MSc, andHeather J. Ross, MD, MHSc

Continued

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Clinical Research - PulmonaryHypertension

672 Hemodynamic Stability After

Transitioning Between EndothelinReceptor Antagonists in Patients WithPulmonary Arterial Hypertension

Benjamin Fox, MB, BS, David Langleben, MD, Andrew M.Hirsch, MD, Robert D. Schlesinger, MD, Mark J. Eisenberg,MD, MPH, Dominique Joyal, MD, Fay Blenkhorn, RN, andLyda Lesenko, RN

678 Incidence and Significance ofPericardial Effusion in Patients WithPulmonary Arterial Hypertension

Avi Shimony, MD, Benjamin D. Fox, MD, David Langleben,MD, and Lawrence G. Rudski, MD

683 Pulmonary Artery Pulse Wave Velocityin Idiopathic Pulmonary ArterialHypertension

Grzegorz Kope�c, MD, PhD, Deddo Moertl, MD, PiotrJankowski, MD, PhD, Anna Tyrka, MD, Bartosz Sobie�n, MD,PhD, and Piotr Podolec, MD, PhD

Clinical Research - MyocardialInfarction

691 Sex Differences in the Management

and Outcomes of Ontario PatientsWith Cardiogenic Shock ComplicatingAcute Myocardial Infarction

Husam M. Abdel-Qadir, MD, Joan Ivanov, PhD, Peter C.Austin, PhD, Jack V. Tu, MD, PhD, and VladimírD�zavík, MD

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Clinical Research - Surgery/Arrhythmia

697 Does Preoperative Atrial Fibrillation

Portend a Poorer Prognosis in PatientsUndergoing Isolated Aortic ValveReplacement? A MulticentreAustralian Study

Akshat Saxena, BMedSc, MBBS, Diem T. Dinh, BASc(Hons),PhD, Christopher M. Reid, BA, MSc, PhD, Julian A.Smith, MBBS, MS, Gilbert C. Shardey, MBBS, MD, andAndrew E. Newcomb, MBBS

704 Change of B-Type NatriureticPeptide After Surgery and ItsAssociation With Rhythm Statusin Patients With Chronic SevereMitral Regurgitation

In-Chang Hwang, MD, Dae-Hee Kim, MD, Yong-JinKim, MD, Kyung-Hee Kim, MD, Seung-Pyo Lee, MD, Hyung-Kwan Kim, MD, Dae-Won Sohn, MD, Byung-Hee Oh, MD,and Young-Bae Park, MD

Basic Research

712 The Effect of Mitomycin-C inReducing Pericardial AdhesionAfter Cardiac Surgery in Rabbits

Necmettin Colak, MD, Yunus Nazli, MD, Irfan Tasoglu MD,Reyhan Bayrak, MD, Mehmet Fatih Alpay, MD, Omer NuriAksoy, MD, Ismail Olgun Akkaya, MD, and Omer Cakir, MD

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Systematic Review/Meta-analysis

718 Transcatheter Aortic ValveImplantation: Recommendations forPractice Based on a MultidisciplinaryReview Including Cost-Effectivenessand Ethical and Organizational Issues

Lucy J. Boothroyd, PhD, Marco Spaziano, MD, Jason R.Guertin, MSc, Laurie J. Lambert, PhD, Josep Rod�es-Cabau, MD,Nicolas Noiseux, MD, Michel Nguyen, MD, Éric Dumont, MD,Michel Carrier,MD,Benoit deVarennes,MD,Reda Ibrahim,MD,GiuseppeMartucci,MD, Yongling Xiao, PhD, JeanE.Morin,MD,and Peter Bogaty, MD

727 Midterm Effects and Clinical Benefitsof Left Ventricular vs BiventricularPacing in Heart Failure

Meng Jiang, MD, PhD, Jia-liang Mao, MD, PhD, Jun Pu, MD,PhD, and Ben He, MD, PhD, FACC

Review

734 Air Pollution and Arrhythmic Risk:The Smog Is Yet to Clear

Alex Watkins, Marlon Danilewitz, BSc, Marjan Kusha, MEng,St�ephane Mass�e, MASc, Bruce Urch, PhD, KennethQuadros, MBBS, Danna Spears, MD, Talha Farid, MBBS, andKumaraswamy Nanthakumar, MD

Training/Practice: Training/Health Policy and Promotion

742 Canada’s Contribution to Global

Research in Cardiovascular Diseases

Hai V. Nguyen, PhD, Claire de Oliveira, MA, PhD, HarindraC. Wijeysundera, MD, FRCPC, William W.L. Wong, PhD,Gloria Woo, PhD, Paul Grootendorst, PhD, Peter P. Liu, MD,FRCPC, MSc, and Murray D. Krahn, MD, FRCPC, MSc

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Training/Practice: ContemporaryIssues in Cardiology Practice

747 Impactful Clinical Trials of 2012:

What Clinicians Need to Know

Milan Gupta, MD, FRCPC, and Narendra Singh, MD, FRCPC

Case Report

751 Percutaneous IntrapericardialInjection of Triamcinolone in a PatientWith Incessant Pericarditis: ANovel Technique

Sarah A. Ramer, MD, FRCPC, and John L. Sapp, MD,FRCPC, FHRS

751 Selective Left Ventricular SensingLead Implantation to OvercomeUndersensing of VentricularFibrillation During ImplantableCardioverter DefibrillatorImplantation

Christian Steinberg, MD, François Philippon, MD, GillesO’Hara, MD, and Franck Molin, MD

751 Carcinoid Heart Disease: OutcomeAfter Balloon PulmonaryValvuloplasty

Pedro Carrilho-Ferreira, MD, Doroteia Silva, MD, Ana G.Almeida, MD, PhD, Eduardo Infante de Oliveira, MD, CarlosFerreira, MD, Luís Miranda, MD, Rosário Rosa, MD, PedroCanas da Silva, MD, Henrique Bicha Castelo, MD, PhD, andAntónio Nunes Diogo, MD

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751 Infective Endocarditis Presenting asan Isolated Aneurysm of the PosteriorMitral Leaflet

Philippe Unger, MD,Martine Antoine, MD, Delfyne Hastir, MD,Chantal Dedobbeleer, MD, and Marc Leeman, MD

Images in Cardiology

751 A Forgotten Guidewire CausingIntracardiac Multiple ThrombiWith Paradoxical and PulmonaryEmbolism

Okan Gulel, MD, Korhan Soylu, MD, Serkan Yuksel, MD,Hasan Tahsin Keceligil, MD, and Murat Akcay, MD

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Letters to the Editor

751 What Does Partial MitraClipDetachment Really Mean?

Murat Tavlasoglu, MD, Ahmet Baris Durukan, MD, ZekeriyaArslan, MD, and Hasan Alper Gurbuz, MD

Departments

641 President’s Page

A10 Information for Readers

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