Table of Content for Annexure S. No. Annexure Item …environmentclearance.nic.in/writereaddata/FormB/TOR/Additional...Table of Content for Annexure S. No. Annexure No. ... Stage-1:-ATA-S1

Table of Content for Annexure

S. No. Annexure

No.

Item Page No.

1. Annexure 1 Existing and Proposed products mix with

capacity

1

2. Annexure 2 Land possession certificate 5

3. Annexure 3 Production and manufacturing processes of new

APIs

6

4. Annexure 4 TSDF, RAMKY Aggrement up to 2018(ML15) 23

5. Annexure 5 TSDF, Gomti Aggrement uptto 2018 (ML15) 34

6. Annexure 6 KSPCB consent ML15 FOR -15-16 35

7. Annexure 7 Schematic of ETP cum Reverse Osmosis Plant 46

8. Annexure 8 Agreement with Tanker for Water Supply

(ML15)

47

9. Annexure 9 Annexure 9, Raw Materials MSDS 51

10. Annexure 10 APIs MSDS 393

11. Annexure 11 EC-MoEF (ML15) 443

12. Annexure 12 CFE ML15 DG 2013 449

13. Annexure 13 List of Raw Materials for proposed New APIs 453

14. Annexure 14 Water Balance Chart existing 20 June 16 483

15. Annexure 15 Water Balance Chart after prop expn 20 June 16 484

16. Annexure 16 Green Belt drawing after proposed expansion 485

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Existing and Proposed products mix and capacity

Existing APIs 65 Nos 36445 (Kg/A)Dropped from existing APIs 39 Nos 5695 (Kg/A)Retained in existing APIs 26 Nos 30750 (Kg/A)Newly introduced APIs 67 Nos 5695 (Kg/A)Total APIs Proposed 26+67=93 Nos 36445 (Kg/A)

Capacity is same, only number of APIs is increased in the products mix.

S. No Product Name Existing Capacity(Kg/A)

After ProposedExpansion Capacity

(Kg/A)

1. Clopidogralbisulfate 500 0

2. Telmisartan 1200 1200

3. Losartan potassium 4000 30004. Torsemide 600 3005. Ebastine 1800 18006. Pantoprazole sodium 600 3007. Rabeprazole sodium 600 08. Amolodipine besylate 50 0

9. Atorvastatin calcium 50 010. Olanzapine 600 30011. Sertraline hydrochloride 50 0

12. Levocertiizine dihydrochoride 50 0

13. Ezetimibe 50 5014. Ramipril 50 0

15. Ropinirole 50 016. Valsartan 300 5017. Escitalopram oxalate 600 1860

18. Pregabalin 300 019. Dorzolamide Hydrochloride 100 500

20. Meloxicam 100 100

21. Glimepiride 600 20022. Gemifloxacin 100 0

23. Nebivolol Hydrochloride 60 60

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24. Memantine Hydrochloride 60 0

25. Olmisartan medoxomil 600 300

26. Citicoline sodium 50 027. Diacerin 50 0

28. Acyclofenac 50 029. Fluorometholone 50 030. Brimoidine Tartrate 240 50

31. Zolpidem Tartarate 300 032. Prulifloxacin 300 033. Levodropropizine 50 0

34. Gliclazide 3000 300035. Melitracen 50 036. Flupentixol 50 037. Olapatdine Hydrochloride 240 0

38. Citalopram Hyrobromde 100 0

39. Brinzolamide 120 5040. Artemether 2000 150041. Lumefantrine 12000 400042. Bosentan 200 043. Prasugrel Hydrochloride 150 0

44. Donepezil Hydrochloride 100 0

45. Amisulpride 500 046. Ranolazine 500 047. Celecoxib 300 8000

48. Duloxetine Hydrochloride 200 0

49. Ziprasidone Hydrochloride 100 0

50. Artesunate 100 051. Montelukast 100 2552. Omperazole magnesium trithydrate 100 053. Aliskiren 50 0

54. Ozagrel 50 0

55. Ramlton 50 056. Bromfenac 25 25

57. Cyclizine Hydrochloride 300 2000

58. Irbesartan 800 2000

59. Fexofenadine Hydrochloride 300 0

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60. Triflusal 100 0

61. Etoricoxib 100 062. Nepafenac 100 5063. Paliperidone 100 064. Zolmitriptan 100 065. Candesartan 300 3066. Abacavir Sulfate 0 30067. Acrivastne 0 50

68. Alcaftadine 0 5069. Anagliptin 0 5070. Apixaban 0 1071. Atazanvir 0 5072. Azilsartan Medoxmil Pottasium 0 250

73. Bepotastine Besylate 0 10

74. Besifloxacin Hydrochloride 0 10

75. Bilastine 0 10

76. Bisegliptin 0 5077. Canagliflozine 0 50

78. Cilnidipine 0 10079. Cyamemazine Tartarate 0 300

80. Dabigatran Etexylate Mesylate 0 250

81. Darunavir Ethanolate 0 300

82. Dolutegravir 0 1583. Empagliflozine 0 5084. Emtricitabine 0 5085. Ethambutol Hydrochloride 0 500

86. Flurbiprofen 0 5087. Iioperidone 0 5088. Isopropterenol Hydrochloride 0 5

89. Ivabrdine 0 5090. Lacosamide 0 5091. Lafutadine 0 5092. Levomilnaciprn Hydrochloride 0 100

93. Lurasidone Hydrochloride 0 100

94. Meptazinol 0 50

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95. Milnacipran Hydrochloride 0 300

96. Mirabegron 0 5097. Moxifloxacin 0 5098. Moxonidine 0 5099. Nefopam 0 50

100. Nephazoline Hydrochloride 0 100

101. Perampanel 0 50102. Rasagiline Mesylate 0 10

103. Rasigiline Tartarate 0 10

104. Rilpivirine 0 50105. Rivaroxaban 0 50106. Rosuvastatin 0 20

107. Sitagliptin 0 20108. Sodium Nitroprusside 0 20

109. Sofosbuvir 0 50110. Sollfenacin 0 20111. Teneligliptin 0 100112. Ticagrelor 0 20113. Vilazidone 0 100114. Vildagliptin 0 100115. Anagrelide 0 50116. Dapagliflozine 0 50117. Tenofovir Alafenamide Fumerete 0 50118. Pilferridone 0 50119. Refaxmine 0 50120. Hexamine Hippurate 0 500121. Tofactinib Citrate 0 15122. Dimethyl Fumarate 0 250

123. Cyclserine 0 50124. Sacrubitil Valsartan 0 50125. Gatifloxacin 0 50126. Daclatasavir 0 50127. Dalfampyridine 0 50128. Brexpiprazole 0 50129. Flupiritine Maleate 0 50130. Omagrigliptin 0 50131. Clobazam EC 0 50132. Febuxostat 0 50

Total 36445 36445

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1). Abacavir Sulfate: Brief manufacturing process:

Stage-1-Condensation of N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide with (1S-cis)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tatrate in the presence of sodium carbonate and IPA to get Stage-1.

Stage-2-Stage-1reactes with triethyl orthoformate in the presence of IPA-HCl to get Stage-2.

Stage-3-Stage-2 reacts with cyclopropyl amine and succinic acid the presence of IPA to get Stage-3.

Stage-4-Stage-3 reacts with sulfuric acid in the presence of IPA and water to get Abacavir sulfate.

2). Acrivastine: Brief Manufacturing Process:

Synthesis of Acrivastine involves four steps-

Stage-1:-The 2,6-dibromopyridine reacted with 4-tolunitrile in the presence of n-BuLi to give the 2-bromo-6-(4-toluoyl)pyridine (compound-1).

Stage-2:-Compound-1 (2-bromo-6-(4-toluoyl)pyridine) undergoes Heck reaction with ethyl acrylate in presenceof triethyl amine, palladium acetate and triphenyl phospine to give (E)-3-(6-(3-pyrrolidino-1-(4-toluoyl)prop-1E-enyl)-2-pyridyl)acrylic acid (compound-2)

Stage-3-Compound-2 ((E)-3-(6-(3-pyrrolidino-1-(4-toluoyl)prop-1E-enyl)-2-pyridyl)acrylic acid) undergoesWittig reaction with triphenyl-2-pyrrolidinoethylphosphonium bromide in the presence of n-BuLi to give themixture of esters (E:Z isomers).(compound-3)

Stage-4Isomerization of (compound-3) was carried out with Coc.H2SO4 followed by esterification with ethanoland sodium hydroxide to give compound Acrivastine.

3). Alcaftadine: Brief Manufacturing Process

Stage- 1-11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (1) was reacted withformaldehyde in presence of sodium hydroxide by using Formic acid as a solvent at temperature 75-80 °C to give(2). Further it was treated with formaldehyde in presence of potassium acetate by using Acetic acid as a solventat temperature 90-95 °C to give (iii) and followed by oxidation with Manganese dioxide, using chloroform as asolvent at temperature 55-60 °C, it give Alcaftadine

4). Anagliptin: Brief Manufacturing Process

Stage – 1-tert-butyl (2-amino-2-methylpropyl) carbamate was reacted with (2S)-1-(chloroacetyl)pyrrolidine-2-carbonitrile in presence of Potassium carbonate and Sodium iodide by using Acetone as a solvent at roomtemperature to give (iii). Further it was de-protected with HCl/ Dioxane at room temperature to give (iv) andfollowed by amide coupling with 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid in presence of CDI andtriethylamine, using THF as a solvent at room temperature to Anagliptin.

5). Apixaban: . Brief Manufacturing Process

Stage-1:-3-Chloro-1-(4-nitrophenyl)-5,6-dihydro-pyridine-2(1H)-one and ethyl chloro[(4-methoxyphenyl)hydrazono] acetate were coupled to form the pyrazole ring using triethylamine in toluene at refluxingtemperature.

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Stage-2:-The nitro group of coupled intermediate was reduced to amine by catalytic hydrogenation using Pd/C inTHF under a hydrogen atmosphere, followed by coupling with 5-Bromovaleryl chloride in presence of aq.K2CO3.

Stage-3:-The cyclization was performed using potassium ethoxide in THF-water to form the lactum.

Stage-4:- The ethyl ester of lactum intermediate was reduced to the corresponding amide using anhydrousammonia gas in propylene glycol at 90ºC.

6). Atazanvir Sulfate: Brief Manufacturing Process

Stage-1:-ATA-S1 and ATA-S2 were suspended in isopropyl alcohol and refluxed for 16 hrs. Cool the reactionmass to room temperature filtered and washed with IPA to obtained ATA-1 as a solid.

Stage-2:-Part-A: The ATV-1 and dilute Hydrochloric acid (6N HCl) were suspended in dichloromethane andrefluxed for 6 hrs. Cool, separate the layers and the aqueous layer containing HCl salt of ATA-2.

Part-B: To the another flask ATA-S3, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) &1-Hydroxy-benzotriazole (HOBT) were suspended in dichloromethane and stirred for 4 hrs at room temperature.The aqueous layer of ATA-2 obtained in part-A and N, N-Diisopropyl ethylamine were added and stirred for 3hrs. Separate the organic layer and washed with water. The resulting compound (ATA-3) was isolated fromacetonitrile.

Stage-3: The ATA-3 was suspended in IPA and Con. Sulphuric acid was added at room temperature. Stirred for1 hr, added n-Heptane as an antisolvent and continued the stirring for 10-12 hrs, filtered the precipitated solidand washed with 1:1 mixture of IPA & n-Hepatne to obtained ATA-4 as a solid.

Stage-4: The ATA-4 was purified in a mixture ethanol and n-Heptane to obtained pure atazanavir sulfate (ATA).

7). Azilsartan Medoxmil Potassium: Brief manufacturing Process

Stage-1-Methyl-1-[(2′-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate reacts withhydroxylamine hydrochloride in the presence of Triethylamine and sodium carbonate to give methyl-2-Ethoxy-1-[[2’-(hydroxyamidino)biphenyl-4-yl]methyl]-1H-benzimidazole-7-Carboxylate .

Stage-2-Condensation of stage-1 with ethyl chloroformate in presence of sodium carbonate and then hydrolysisin the presence of sodium hydroxide to give Methyl-1-[[2’-(2,5-Dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate.

Stage-3-Condensation of stage-2 with medoxomil alcohol in the presence of 4-toluenesulfonyl chloride andpotassium carbonate to give (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-Ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Stage-4-Stage-3 reacts with potassium 2-ethylhexanoate in acetone to give (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-Ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate potassium

8). Bepotastine Besilate :Brief Manufacturing Process:-

4 chloro phenyl 2 pyridyl Methoxypipridine Tartaric acid is reacted with Ethyl -4- bromobutyrate in thepresence of potassium carbonate to give ethyl 4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-

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yl)butanoate, which is then reacted with Fumaric acid to give ethyl 4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoate fumarate salt ,then hydrolysed it in the presence of ethanol and Sodiumhydroxide to get Bepotastine which is further reacted with benzene sulfonic acid to give Bepotastine Besilate.

9). Besifloxacin HCl: Brief manufacturing Process

Stage-1-Condensation of 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid with (3R)-azepan-3-amine mandelate in the presence of acetonitrile and trimethylamine to get 7-[(3R)-3-aminoazepan-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hemimandelate (BES-1)

Stage-2-Stage-1 reacts with sulfuryl chloride in the presence of acetic acid and acetone to get 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid Hydrochloride (BES-2)

Stage-3-Purification of crude stage-2 in methanol and water to get pure besifloxacin hydrochloride

10). Bilastine : Brief Manufacturing Process:-

Mesyl chloride reacted with bromophenethyl in MIBK with the presence of TEA gives ethyl(1-4 bromopheneethyl) pipridine carboxylate which reacted with again N(2 ethoxy ethyl )benzene1,2 diamine which wasprepared by using 2 ethoxy ethyl amine and fluoro nitrobenzene gives 2(1-4 bromo phenethyl) N(2(2 ethoxyethyl)amino)phenyl pipridine 4-carboxamide,after cyclisation in heating H product formed which gives I productby using TMS enolates.

Further rected with fumaric acid in MIBK Bilastine fumarate formed which reacted with Potassium hydroxidegives Bilastine

11). Bisegliptin:Brief Manufacturing Process:-

Benzene sulfonyl chloride reacted with (2S,4S)4-fluoro-1-(2-hydroxyacetyl)pyrrolidine-2-carboxamide inACETONITRILE with the presence of TEA gives (2S,4S)1,2(benzenesulfonylyloxyacetyl)-4-fluoro-pyrrolidine-2-carboxamide which reacted with acetic anhydride gives (2S,4S)1,2(benzenesulfonylyloxyacetyl)-4-fluoropyrrolidine-2-carbonitrile & it coupled with ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate in thepresence of K2CO3 gives Ethyl 4-({2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl}amino)bicyclo[2.2.2]octane-1-carboxylate Bisegliptin.

12). Canagliflozine:Brief Manufacturing Process:

Synthesis of Canagliflozin involves seven steps-

Stage-1:-A solution of 2-chlorothiophene in THF was reacted with 5-bromo-2-methylbenzaldehyde in thepresence of n-buLi to give (Compound-1).

Stage-2 -Compound-1 reacted with solution of 2,3,4,6-tetrakis-o-trimethylsilyl-D-glucono-1,5-lactone intoluene in the presence of n-buLi to give lactol (Compound-2).

Stage-3 -Compound-2 (lactol) reacted with methane sulphonic acid in methanol to give (Compound-3).

Stage-4 -Compound-3 reacted with reacted with triethyl silane, boron trifluoride etherate in DCM to give 1-(β-D-glucopyranosyl)-3-(5-chloro-2-thienylmethyl)-4-methylbenzene (Compound-4).

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Stage-5-Compound-4 [1-(β-D-glucopyranosyl)-3-(5-chloro-2-thienylmethyl)-4-methylbenzene] reacted withacetic anhydride to give 1-(2,3,4,6-tetra-O-acetyl- β-D-glucopyranosyl)-3-(5-chloro-2-thienylmethyl)-4-methylbenzene (Compound- 5).

Stage-6-1-(2,3,4,6-tetra-O-acetyl- β-D-glucopyranosyl)-3-(5-chloro-2-thienylmethyl)-4-methylbenzenecompound- 5 reacted with 6-Fluoro-phenyl boronic acid, KF, tri tert butyl phosphine, tris dibezylidene acetonedipalladium in THF to give 1-(2,3,4,6-tetra-O-acetyl- β-D-glucopyranosyl)-3-(5-(4-fluorophenyl)-2-thienylmethyl)-4-methylbenzene (Compound-6)

Stage-7-A solution of Compound-6 [1-(2,3,4,6-tetra-O-acetyl- β-D-glucopyranosyl)-3 with 2N NaOH to givethe Canagliflozin

13). Cilnidipine:Brief Manufacturing Process

(2E)-3-phenylprop-2-en-1-ol[KSM (i)] was reacted with 4-methylideneoxetan-2-one in presence of sodiummethoxide by using Methanol as a solvent at temperature 0-10 °C to give (ii).

Further it was treated with Ammonia to give (iii) product by using Isopropanol as a solvent at room temperature0-10 °C and followed by coupling with KSM (ii) in presence of sodium ethoxide, using Ethanol as a solvent attemperature 0-10 °C, it give Cilnidipine.

14). Cyamemazine Tartarate:Brief Manufacturing Process:

Cyamemazine free base synthesized by a condensation reaction which consists of 2-cyano phenothiazine and3-dimethyl amino-2-methyl propylchloride Hydrochoride in presence of Potassium carbonate as base andacetone as solvent, which affords Cyamemazine Free Base.

15). Dabigatran Etexylate Mesylate:Brief Manufacturing Process:

Stage-1-The DAB - S2 reacts with CDI in presence of ethyl acetate at 30-350C temperature under nitrogenatmosphere to form the amide ester complex which further reacts with DAB-S1 to form DAB -1A. This willundergo Cyclization in presence of acetic acid and ethyl acetate to yield DAB-1.

Stage-2-DAB-1 reacts with HCl in presence of ethanol at 10-15°C to give DAB-2A which further treated withammonia in presence of ethanol to produce DAB -2B. DAB-2B reacts with DAB-S3 in presence of potassiumcarbonate in a mixture of water and DCM to yield DAB-2, which is further purified in Ethyl acetate.

Stage-3-DAB-2 and Acetone give Charcoal treatment filter through hyflo and 0.4 micron filter then AcetoneMLR charged into the RBF then reacts with Methanesulfonic acid in presence of acetone to give DAB.

16). Darunayir Ethanolate:Brief Manufacturing Process

Stage - 1:-KSM-1 (Phenylepoxycarbamate) is condensed with isobutyl amine (KSM-2) in presence of IPA assolvent at room temperature to result Intermediate-2. Intermediate-1thus obtained from stage-1 is further reactedwith KSM-3 (4-nitrobenzenesulphonyl chloride) at 0-10 ºC in chlorinated solvent followed by workup processwith distillation of organic volatiles and isolation with water results to afford Intermediate-2.

Stage -2-Intermediate-2 obtained in stage is further subjected to reduction in presence of Pd/C and methanol atroom temperature followed by filtration of catalyst and evaporation results to furnish Intermediate-3 which ontreatment with concentrated hydrochloric acid at 0-10 ºC in organic solvent such as DCM/EtOAc yield toIntermediate-4 after filtration

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Stage -3-Intermediate-4 is condensed with KSM-4 (Bifuranyl succinimidyl carbonate) at 10-15 ºC in presenceof bipolar aprotic solvent. After completion of reaction, water is added to reaction mass for precipitation ofdesired compound which on filtration results to afford darunavir crude mass. After drying darunavir crude massunder vacuum, is converted further to its ethanolate solvate by dissolving it in ethanol at reflux temperaturefollowed by cooling to 0-10 ºC and filtration results darunavir ethanolate as per our desired quality profile.

17). Dolutegravir Sodium:Brief Manufacturing Process

Stage-1:-Dimethyl-3-(benzyloxy)-4-oxo-4H-pyran-4,5-dicarboxylate and aminoactaldehyde dimethyl acetalwere reacted in methanol at refluxing temperature to prepare pyridonediester intermediate. The solvent wasdistilled off from the reaction mass and recrystallized by repeating addition of ethyl acetate and concentratedand isolated as white crystals.

Stage-2:-The pyridonediester intermediate in formic acid solution was reduced to corresponding aldehydeunder acidic condition, using 62% sulphuric acid at room temperature. The reaction was worked up usingmethylene dichloride and water by making the pH adjustment to 6.6 using saturated aq. NaHCO3 solution undercooling condition (5ºC). (R)-3-amino-butan-1-ol in a mixture of methanol and acetic acid was reacted withtoluene solution of the aldehyde intermediate under refluxing condition to prepare the cyclic fused ringintermediate, worked-up using ethyl acetate and washed with saturated aq. NaHCO3 solution followed by brinesolution.

Stage-3:-The cyclic intermediate was coupled with 2,4-diflurobenzyl amine in toluene and acetic acid to affordbenzyl derivative of dolutegravir under refluxing temperature.

Stage-4:-The debenzylation of benzylated dolutegravir was performed using Pd/C in tetrahydofuran-methanolunder hydrogen atmosphere to afford corresponding hydroxyl derivative, i.e., dolutegravir.

Stage-5:-Dolutegravir further converted to dolutegravir sodium by addition of 2N sodium hydroxide underheating condition in ethanol-water .

18). Empagliflozin:Brief Manufacturing Process:

Synthesis of Empagliflozin involves seven steps-

Stage-1:-5-bromo-2-chlorobenzoic acid reacted with oxalyl chloride, DMF, to give residue. The residue reactedwith anisole and aluminum trichloride in DCM to give (5-bromo-2-chlorophenyl)-4-(4-methoxyphenyl)methanone (Compound-1).

Stage-2 -Compound-1 [5-bromo-2-chlorophenyl)-4-(4-methoxyphenyl)methanone] reacted withtrimethylsilane and boron trifluoride etherate in DCM and acetonitrile to give 4-bromo-1-chloro-2-(4-methoxybenzyl)benzene (Compound-2).

Stage-3 -Compound-2 [4-bromo-1-chloro-2-(4-methoxybenzyl)benzene] reacted with boron tribromide inDCM to give 4-(5-bromo-2-chlorobenzyl)phenol (Compound-3).

Stage-4 -Compound-3 [4-(5-bromo-2-chlorobenzyl)phenol] reacted with tert-butyldimethylsilyl chloride,triethyl amine, 4-dimethyl aminopyridine in DCM to give [4-(5-bromo-2-chlorobenzyl)phenoxy]tert-butyldimethyl silane (Compound-4).

Stage-5-A solution of D-glucono-1,5-lactone, N-methylmorpholine in THF reacted with trimethylsilyl chlorideto give 2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucopyranone (Compound-5).

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Stage-6-To a solution of Compound-4 [4-(5-bromo-2-chlorobenzyl)phenoxy]tert-butyl dimethyl silane inether, tert-butyl lithium in pentane was added at -800C. To above solution Compound-5 [2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucopyranone] in ether was added at -800C. To above solution, methane sulphonic acid inmethanol was added to give the residue. The residue reacted with triethyl silane, boron trifluoride etherate inDCM and CAN to give the product in an approx.. 6:1 mixture of β/α which can be converted into β-anomer byacetylation of hydroxyl groups with acetic anhydride and pyridine. The product was then deacetylation inmethanol with aq.KOH to give the 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)benzene(Compound-6)

Stage-7-Compound-6 [1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)benzene] reacted with (R)-3-(4-methylphenylsulfonyloxy)-tetrahydrofuran in presence of cesium carbonate and DMF to give 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxybenzyl)benzene (Empagliflozin)

19). Emtricitabine:Brief manufacturing process

Reduction of AOC with sodium borohydride in the presence of Methanol to get EMT-1, further EMT-1converted to EMT using triethylamine as a base and MDC as a solvent.

20). Ethambutol Hydrochloride :Brief manufacturing process:

Condensation of Dichloroethane with D-2-aminobutanol to get crude ethambutol hydrochloride, this is featherpurified in IPA to get pure ethambutol hydrochloride.

21). Flurbiprofen :Brief Manufacturing Process

Stage-1:Bromopropionic acid is converted to crystalline sodium 2-bromopropionate under anhydrous conditionin toluene using methanolic sodium methylate. The product was isolated by filtration and dried under vacuum.

Stage-2:-4-Bromo-2-fluorobiphenyl was reacted with magnesium in anhydrous THF to form the Grignardreagent. The reaction mass was as such treated with sodium 2-bromopropionate to form flurbiprofen. Thereaction was quenched with ammonium chloride, distilled off THF and isolated from water by addition ofCon.HCl. The filtered material was dried under vacuum.

Stage-3:-Purification of crude flurbiprofen in refluxing toluene afforded pure product of desired melting rangeand free of impurities.

22). Iloperidone:Brief Manufacturing process:

Stage-1:-Condensation of ILO-S1 with 1-bromo-3-chloropropane in the presence of potassium carbonate to getILO-1.

Stage-2: -Condensation of ILO-1 with ILO-S3 in the presence of potassium carbonate and DMF to getIloperidone

23). Isoproternol HCl:Brief Manufacturing Process:

Synthesis of Isoproterenol hydrochloride involves seven steps (including two insitu steps):

Stage-1-The preparation of ISO-2 from ISO-S1 includes two steps.

1. ISO-S1 undergoes Friedel-Craft reaction with chloroacetyl chloride in the presence of aluminumchloride in EDC followed by quenching with HCl and filtration to give ISO-1

2. The second step involves protection of carbonyl group of ISO-1 with ethylene glycol to yield ISO-2.

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Stage—2- The preparation of ISO-4 from ISO-2 includes two steps

1. Protection of hydroxyl group of ISO-2 in presence of potassium carbonate in acetone to give ISO-3.2. The next step involves the de-protection of acetal group of ISO-3 in the presence of conc. HCl to yield ISO-4.

Stage-3-SO-4 undergoes reaction with ISO-S2 in ethanol followed by hydrochloride salt formation with HCl togive ISO-5.

Stage-4-ISO-5 undergoes de-benzylation and reduction of carbonyl group in presence of Pd/C underhydrogenation to give ISO-6.

Preparation of ISO:The last step is the purification of ISO-6 in ethanol to yield ISO (Isoproterenol).

24). Ivabradine Hydrochloride; Brief Manufacturing Process:

Synthesis of Ivabradine consists of two steps, 1 st steps involves the condensation of INT-I with chiral amine(INT-II) in presence of Potassium tert butoxide as base DMSO as solvent, affords coupled compound which ishydrogenated with H2 over Pd(OH)2 gives IVABRADINE Free Base, Further Prepared its HCl Salt usingmethanolic HCl .

25). Lacosamide: Brief Manufacturing Process:

It is two step processes. The first steps involve the reaction of D- serine with boc. anhydride to give LAC-1.Which is undergoes amination with benzylamine in presence of N-methylmorpholine followed by methylationwith Dimethyl sulphate to yield LAC-3. The LAC-3 finally converted into Lacosamide by de-protection of Boc.and acylation reaction.

26). Lafutadine: Brief Manufacturing Process

Stage-1:-(Z)-4-Aminobut-2-en-1-ol was dissolved in THF and cooled to 0-5oC. 60% NaH was added undernitrogen atmosphere and stirred at room temperature for 30 minutes. A THF solution of 2-bromo-4-((piperidin-1-yl)methyl)pyridine was added dropwise at room temperature and the reaction was refluxed for 28h forreaction completion. The reaction was carefully quenched with water; THF was distilled and extracted withdichloromethane. The combined dichloromethane layers were washed, dried and concentrated to afford productas oil.

Stage-2:-The stage-1 material was mixed with 4-nitrophenyl 2-((furan-2-yl)methylsulfinyl)acetate in ethylacetate and stirred at room temperature till the completion of the reaction. After the completion of the reaction,water was added followed by hydrochloric acid and the layers were separated. The organic layer was washedsubsequently with sodium hydroxide solution, separated and concentrated under reduced pressure to affordresidue of crude lafutidine. Ethanol was charged to the reaction mass, heated to clear and cooled down to affordsolid material. Filtration, washing and drying afforded pure Lafutidine.

27). Levomilnaciprn Hydro chloride: Brief Manufacturing Process

Stage-1

LEV-S1 reacts with LEV-S2 in presence of DCM which gives LEV-1 intermediate and then it again processedto give LEV-2 intermediate and further processed to give LEV-3 intermediate and further it gives LEV-4.

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Stage-2

LEV-4 again purified to give LEV.

28). Lurasidone HCl;Brief Manufacturing Process

Stage - 1:-Cyclohexane dihydroxyl (KSM-1) is treated with mesylchloride in presence of Triethyl amine andDCM to result dimesylated cyclohexane which is further condensed with piperazine thioazo (KSM-2) inpresence of sodium carbonate and acetonitrile results to furnish Intermediate-1.

Stage -2-Intermediate-1 thus obtained in stage-1 is further subjected to condensation with bicylcosuccinimide(KSM-3) in presence of potassium carbonate and acetonitrile at reflux temperature followed by filtration tofurnish Intermediate-2 (Lurasidone base) which on treatment with IPA.HCl at 30-40 ºC in IPA such asDCM/EtOAc yield to Lurasidone hydrochloride after filtration

29). Meptazinol:Brief manufacturing process:

Stage-1:-Condensation of MEP-S1 with MPE_S2 to in the presence of THF as a solvent to get MEP-1

Stage-2:-Cyclisation of MEP-1 using Raney nickel to get MEP-2

Stage-3:-Reduction of MEP-2 with LiAlH4 in the presence of THF as a solvent to get MEP-3

Stage-4:-Demethylation of MEP-3 with aq HBr to get MEP-4

Stage-5:-N- methylation of MEP-4 using Pd/c and aq formaldehyde to get MEP

30). Milnacipran HCl:Brief Manufacturing Process

Stage-1:-The (1S*, 5R*)-1-phenyl-3-oxabicyclo [3, 1, 0] hexan-2-one (MCH-0) is reacts with diethyl amine inpresence of aluminum chloride in toluene as a solvent under nitrogen atmosphere at -5 to 0°C to get (1S*, 5R*)-N, N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane carboxamide The resulting hydroxyl moiety chlorinatedwith thionyl chloride in toluene as solvent. The resulting acid chloride is reacted with sodium azide in presenceof DMF as a solvent at 50-600C to get an (1S*, 2R*)-2-azidomethyl –N, N-diethyl-1-phenylcycloropropanecarboxamide. This is then reduced With TPP in ethyl acetate at 75-800C. Thus, theMilnacipran hydrochloride is isolated from ethyl acetate

Stage-2:-Crude Milnacipran hydrochloride (MCH-1) was dissolved in isopropyl alcohol at 40-45°C and passedthe clear solution through micron filter paper. The milnacipran hydrochloride was isolated from ethyl acetate.

31). Mirabegron: Brief Manufacturing Process

Stage-1:-Mandelic acid and 4-nitrophenylethylamine were coupled using EDC.HCl and HOBT in DMF at roomtemperature. The reaction was worked up using ethyl acetate and water and the crude mass was recrystallisedfrom toluene.

Stage-2:-The amide intermediate in THF was reduced to amine using diborane gas generated in situ usingsodium borohydride and boron trifluoride ethyl etherate, worked-up using ethyl acetate and isolated ashydrochloride by addition of con.hydrochloric acid.

Stage-3:-Catalytic hydrogenation of nitro group using Pd/C in methanol under a hydrogen atmosphere followedby filtration and solvent evaporation afford the amino compound.

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Stage-4:- The diamine intermediate was chemoselectively coupled with 2-(4-aminothiazol-4-yl)acetic acidusing EDC.HCl in water at acidic pH to afford mirabegron which was isolated as solid after basification of thereaction mass using sodium hydroxide.

32). Moxifloxacine HCl:Brief Manufacturing Process:

Synthesis of moxifloxacin involves two steps-

Stage-1:-The 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid reactedwith (S,S)-2,8-diazabicyclo[4.3.0] nonane in the presence of triethyl amine and acetonitrile to give themoxifloxacin base (compound-1).

Stage-2:-Compound-1 (moxifloxacin base) treated with methanolic hydrochloric acid and methanol to give 1-cyclopropyl-7-[(1S,6S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4-oxo-quinnoline-3-carboxylicacid hydrochloride (moxifloxacin hydrochloride)

33). Moxonidine: Brief Manufacturing Process

Stage-1:-5-Amino-4, 6-dichloro-2-methyl pyrimidine (MPA) and 1-acetyl-2-imidazolone (AIZ) were reacted inpresence of phosphoryl chloride at 90-95ºC. The product was isolated by the addition of reaction mass to amixture of cooled water, ammonia and ethyl acetate under cooled condition (5ºC) and and the crude mass wasrecrystallized from ethyl acetate.

Stage-2:-The MXD-1 was converted to MXD-2 using potassium carbonate in methanol under refluxingtemperature. The reaction was worked up by diluting the reaction mass with water followed by adjustment ofthe reaction mass pH to acidic and basic by the addition of acetic acid and ammonia respectively. The productwas isolated by filtration under vacuum and suck dried.

Stage-3:-The MXD-2 was converted to MXD-3 using oxalic acid dehydrate in n-propanol at 90-95ºC. Productwas isolated by filtration under vacuum and suck dried after cooling to room temperature and the crude masswas recrystallized from n-propanol and water.

Stage-4:-The process water was added to MXD-3 and active carbon was added to the reaction mass at 30-35ºC.After filtration through hyflo, the product was isolated from the filtrate by adjusting the pH to 7.5-8.5 by theaddition of aqueous ammonia at 25-30ºC. Product was filtrated under vacuum and suck dried.

34). Nefopam:Brief Manufacturing Process

Stage -1-[2-(chloromethyl) phenyl](phenyl) methanone was reacted with Methyl amino ethanol in presence ofSodium carbonate by using Ethanol as a solvent at temperature 75-80 °C to give (ii) Further it was treated withSodium borohydride at temperature 25-30 °C to give (iii) and followed by cyclization in presence of p-toluenesulfonic acid, using Toluene as a solvent at temperature 100-110 °C, it give Nefopam base and furtherconverted into Nefopam hydrochloride salt by using IPA.HCl in Isopropanol.

35). Naphazoline Hydrochloride:Brief Manufacturing Process

Stage – 1(NPZ-1):-1-Naphthyl acetonitrile is reacted with MeOH in presence of HCl gas by using MTBE as asolvent at 0 to 50 C , to give NPZ-1.

Stage -2 (NPZ-2):- NPZ-2 was prepared by the condensation of NPZ-1 with Ethylenediamine in MeOH at 5 -10 0C.The reaction was completed within 20-30 hrs and after workup it was treated with IPA.HCl, to affordNPZ-2 as a hydrochloride salt.

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Stage – 3(NPZ-3):-The NPZ-3 was obtained when NPZ-2 is purified by a mixture of MeOH and MTBE.

36). Perampanel:Brief manufacturing process:

Stage-1:-Condensation of PER-S1 with PER-S2 in the presence of Cu(OAc)2 to get PER-1

Stage-2:-Condensation of PER-1 with PER-S3 in the presence of Pd (Ph3P)4 to get PER-2

Stage-3:-Condensation of PER-2 with PER-S4 in the presence of Pd (Ph3P)4 to get PER

37). Rasagiline Mesylate: Brief manufacturing process

Stage-1:(RS) 1-aminoindan and propargyl benzenesulfonate in toluene as a solvent and in presence of 15%sodium hydroxide solution as a base. The resulting (RS)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine isresolved by L(+)-Tartaric acid in methanol and Isopropyl alcohol mixture at reflux temperature to get the Di(R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine L-Tartarate.(RSG-1)

Stage-2:-The Rasagiline Mesylate is prepared by adding Methanesulfonic acid to a solution of Di (R)-N-(prop-2-yn-1-yl)-2, 3-dihydro-1H-inden-1-amine L-Tartarate in Acetone and water mixture at reflux temperature.

38). Rasagiline Tartrate:Brief manufacturing process

Stage-1:-(RS) 1-aminoindan and propargyl benzenesulfonate in toluene as a solvent and in presence of 15%sodium hydroxide solution as a base. The resulting (RS)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine isresolved by L(+)-Tartaric acid in methanol and Isopropyl alcohol mixture at reflux temperature to get the Di(R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine L-Tartarate.(RSG-1)

Stage-2:-The Rasagiline tartrate is purified in methanol and Isopropyl alcohol mixture at reflux temperature toget the Di (R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine hemitartrate

39). Rilpivirine HCl: Brief Manufacturing Process

Stage-1:-2,4-Dichloropyrimidine and ethanol were taken in a three neck RB flask at room temperature. Sodiumbicarbonate was added followed by addition of (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile hydrochloride.The reaction mass was heated to reflux and followed by TLC/HPLC for reaction completion. After thecompletion of the reaction, the reaction mass was cooled to room temperature and further chilled down to 10-15oC and the solid formed was filtered. The filtered solid was washed with ethanol and dried u/v to afford stage-1.

Stage-2:-Stage-1 material and 4-aminobenzonitrile were suspended in IPA in a three neck rb flask at ambienttemperature. IPA.HCl was added slowly to the reaction mass and the reaction mass was refluxed to obtain aclear solution. The reaction was continued till completion. After the completion, the reaction mass was cooleddown and the solid formed was filtered, washed and dried to afford stage-2 (crude rilpivirine).

Stage-3:-Methanol and acetone were charged in rb flask followed by addition of crude rilpivirine. The reactionmass was heated till clear and micron filtered. The reaction mass was reheated and cooled down to roomtemperature, filtered and washed with methanol-acetone to afford pure rilpivirine hydrochloride.

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40). Rivaroxaban: Brief Manufacturing Process

Stage-1:-The RIV-S1 and Methanol charged into the RBF then add RIV S2 into the RBF and raise the reactionmass temperature to 60-70 °C and maintaining for 12 hrs at 60-70°C cool the mass to RT then Filter, solid dryfor 8 hrs under vacuum at 45-50°C.

Stage-2:-Charge THF and RIV-1 into the RBF, add D-MAP catalytic amount, add potassium carbonate andCDI heat the reaction mass to 60-65°C and maintaining for 12 hrs cool the reaction mass to 25-30°C add waterinto the reaction mass stir for 2 hrs then filter the mass, wash with THF dry the solid under vacuum for 8 hrs at50-55°C

Stage-3-Charged Methanol and RIV-2 into the RBF add Methyl amine into the reaction mass heat the reactionmass to 60-65°C maintaining for 2 hrs then cool the mass to RT distilled the mass under vacuum for residueobtained add methanol and DIPE filter the mass dry the solid under vacuum for 4 hrs at 35-40°C

Stage-4-Charge RIV- 3 and tri ethylamine in to the RBF add drop wise RIV-S3 acid chloride into the reactionmass (Charge RIV-S3 into the reaction mass add DCM Drop wise added thinly chloride then distil the reactionmass at 30-35°C gives RIV-S3 acid chloride) at 0-5°C, maintaining for 2hrs at 25-30°C add DCM and water into the reaction mass separate the layers organic layer distil out get residue add methanol for purification.

41). Rosuvastatin:Brief Manufacturing Process

Stage – 1-KSM-1 reacted with Tribromoposphorous with using Acetonitrile media to give Bromo compoundand further reacted with triphenyl posphene to formed wittig salt . Further reacted with KSM-2 in the presenceof potassium carbonate with using toluene as solvent to give intermediate and further reacted with Hydrochloricacid , Calsium chloride to give rosuvastatin calcium.

42). Sitagliptin:Brief Manufacturing Process

Synthesis of Sitagliptin involves three steps-

Stage-1:-The (3R)-3-amino-4-[2,4,5-trifluorophenyl] butanoic acid reacted with di tert butyl carbonate in thepresence of sodium hydroxide and t-butanol to give (3R)-3-[(1,1-Dimethyl ethoxy carbonyl)amino]-4-[2,4,5-trifluorophenyl] butanoic acid (compound-1).

Stage-2:-Compound-1 [(3R)-3-[(1,1-Dimethyl ethoxy carbonyl)amino]-4-[2,4,5-trifluorophenyl] butanoicacid] reacted with 3-trifluoromethyl-5,6,7,8-tetrohydro imidazo[1,2-α]pyrazine in the presence of HOBT, EDCand DCM to give compound-2

Stage-3-Compound-2 treated with methanloic HCl to give sitagliptin

43). Sodium Nitroprusside: Brief Manufacturing Process

Stage - 1:-Potassium ferrocyanide (KSM-1) is treated with nitric acid at 50-60 ºC in presence of water assolvent which results to afford dihydrogen nitroprusside (Int-1) as in-situ intermediate. Intermediate-1 is furthertreated with sodium carbonate at 60-70 ºC to result sodium nitroprusside and crystallization of crude sodiumnitroprusside in water results to furnish desired sodium nitroprusside with acceptable quality.

44). Sofosbuvir:Brief Manufacturing Process

Stage- 1-KSM-1 was Reacted with Benzoyl chloride to give intermediate and further reacted with Acetic acidto give Intermediate . The Intermediate condenced with phosphochloridate in THF and presence of 1-

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methylimidazole to give a nucleoside phosphoramidate (Sofosbuvir).Further purified with Ethyl acetate to givepure Sofosbuvir

45). Solifenacin:Brief Manufacturing Process:

Synthesis of Solifenacin succinate involves three steps-

Stage-1:-The 1-phenyl-1,2,3,4-tetrahydroisoquinoline reacted with ethyl chloroformate in the presence oftriethyl amine and dichloromethane to give the ethyl-1-phenyl-1,2,3,4-tetrahydro-2-isoquinoline carboxylate(compound-1).

Stage-2:-Compound-1 (ethyl-1-phenyl-1,2,3,4-tetrahydro-2-isoquinoline carboxylate) reacted with 3-quinuclidinol in the presence of sodium hydride and toluene to give (1S)-(3R)-1-Azabicylco[2.2.2.]oct-3-yl-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate (Solifenacin base, compound-2)

Stage-3-Compound-2 (Solifenacin base) treated with ethanol and succinic acid to give solifenacin succinatewhich recrystallized from isopropanol and isopropyl ether to get pure solifenacin succinate.

46). Teneligliptin ; Brief Manufacturing Process:

Stage-1

TEN-S1 in presence of acetone , Potassium carbonate reacts with DMS to give TEN-1 intermediate which isfurther processed will give TEN-2 .

Stage-2

TEN-2 reacts with TEN-S2 to give TEN-3 intermediate which is further processed will give TEN-4.

Stage-3

TEN-4 reacts with TEN-S3 to give TEN-5 intermediate which is further processed will give TEN-6.

Stage-4

TEN-6 is purified to give TEN.

47). Ticagrelor:Brief Manufacturing Process:

Stage1:-TIC-S1 undergoes condensation reaction with TIC-S2 in presence of potassium carbonate in toluenefollowed by filtration and purification in cyclohexane to give TIC-1

Stage2:- The preparation of TIC-4 from TIC-1includes three steps

1. Cyclization of TIC-1 in presence of sodium nitrite and acetic acid at 5-100C to give TIC-2.2. The next step involves the condensation TIC-2 with TIC-S3 in presence of potassium carbonate to

yield TIC-3.3. The third step involves the de-protection of TIC-3 in presence of conc. HCl at 0-50C followed by

basification, layer separation and isolation in ethyl-acetate and toluene to afford TIC-4.Preparation of TIC:-The last step is the purification of TIC-4 in ethyl-acetate and toluene to give Ticagrelor

pure (TIC)

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48). Vilazodone:Brief manufacturing process

Stage-1:-5-Cyanoindole (VIL-S1) treated with 4-chlorobutyryl chloride (VIL-S2) in presence of base to get the3-(4-chlorobutyryl)-5-methoxyindole; this is reduced with sodium bis (2-methoxyethoxy) Aluminium hydrideto get the VIL-1.

Stage-2:-2-Ethoxy-carbonyl-5-aminobenzofuran (VIL-S3) is treated with N,N-bis(2-chloroethyl)amine (VIL-S4) in presence of base to get the 1-(2-ethoxy-carbonylbenzofuran- 5-yl)piperazine, This is coupled with VIL-1in presence of acetonitrile to get the VIL-2.

Stage-3:-VIL-2 is treated with 2-chloro-1-methylpyridinium methansulfonate in presence of N-methylpyrrolidine and ammonia gas to get the Vilazodone (VIL).

49). Vildagliptin:Brief Manufacturing Process:

The process involves acylation of L-prolinamide with chloroacetyl chloride in the presence of potassiumcarbonate to give acylated product, which is on dehydration with cyanuric chloride yields stage-1 product.Reaction of stage-1 material with 3-amino-1-adamantanol in ACN using potassium carbonate furnishes stage-2material (crude Vildagliptin). This crude vildagliptin on purification in MEK gives pure vildagliptin.

50). Anagrelide: Brief manufacturing process

Stage-1:-6-chloro-1,2,3,5-tetrahydroimidazo (2,1-b)quinazolin-2(3H)-one (ANA-S1) is treated with Chlorine(ANA-S2) in presence of Ferric chloride and Nitromethane to get the Anagrelide

51). Dapagliflozine:Brief Manufacturing Process

Step - 1:-KSM-1is condenced with Ethoxy benzene by using Sodium hydride and Dimethyl formamide as asolvent at temperature 65 to75 Deg C to give Intermediate Further it is Reacted with Sodium hydroxide in thepresence of Tetrahydrofuran to give Inermediate and deprotected with Trimethyl silane in the PresenceAcetonitrile to formed dapagliflozin crude and purified with Ethylacetate and Hexane solvent to got pureDapagliflozin.

Step -2-Reaction mass is centrifuged and dried.

52).Tenofovir Alafenamide Furnerate :Brief Manufacturing Process :-

Adenine is reacted with (R)-propylene carbonate and catalytic amount of a base such as sodium hydroxide togive (R)-9-(2-Hydroxy propyl) adenine ,which is then reacted with p-toluene sulfonyloxymethyl phosphonate inpresence of base such as Magnesium tert butoxide to give (R) -9-[2-(Diethylphosphonomethoxy)propyl]adenine is deesterfied with bromotrimethylsilane to give crude tenofovir, which ispurified by precipitation form water to afford tenofovir mono hydrate, which is then reacted with chloromethylisopropyl carbonate in presence of base such as triethyl amine and organic solvent 1-mehtyl -2-pyrrolidine toafford tenofovir disoproxil.

The obtained tenofovir disoproxil is then reacted with fumaric acid in presence of alcoholic solvent likeisopropyl alcohol to afford tenofovir disoproxil fumarate.

53). Pilferidone:Brief manufacturing Process

5-Methylpyridin-2-(1H)-one reacts with Idobenzene in the presence of potassium carbonate and copper powderto give 5-Methyl-1- phenylpyridin-2-(1H)-one.

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54) Refaximine:Brief Manufacturing Process:

Synthesis of Rifaximin involves one step-

Stage-1:-The rifamycin O reacted with 2-amino-4-methylpyridine, ascorbic acid in the presence ofdemineralized water and ethyl alcohol to give rifaximin.

55). Hexamine Hippurate;Brief Manufacturing Process:

The process involves salt formation of hexamine with hippuric acid in IPA at heating to give hexaminehippurate.

56).Tofactinib Citrate ; Brief Manufacturing Process:

Step - 1: TOF-S1 reacts with Para toluene sulfonyl chloride in presence of NaOH and water to give TOF-1 intermediateWhich further reacts with TOF-S2 in the presence K2CO3 ,Water, NaOH, Water to give TOF-2 intermediate

Step -2 TOF-2 react with pd(OH)2 in presence of IPA to give TOF-3. TOF-3 react with ECA, DBU, and n-Butanol, toproduce TOF Tofacitinib citrate.

57). Dimethyl Fumarate ; Brief manufacturing process:

Stage-1:

DIM-1 is under goes insitu reaction by esterification of fumaric acid in presence of acetyl chloride by usingmethanol.

Stage-2:

DIM is the purification of DIM-1 wet solid by insitu reaction.

58). Cyclserine: Brief manufacturing process:

Stage-1 CYC-S1 is undergoes esterification in presence of acetyl chloride in methanol to yielded CYC-1.

Stage-2 To get CYC-2 by the chlorination of hydroxyl group in presence of thionyl chloride and using dixaneas a solvent.

Stage-3 To get CYC-3 by transformation of methyl carboxylic esters into hydroxamic acid withhydroxylamine hydrochloride in presence of sodium hydroxide and using IPA as a solvent.

Stage-4 Cyclization reaction of the chloro with the hydroamic acid moiety of CYC-3 with sodium hydroxide asbase through nucleophilic reaction in one-pot operation to get CYC-4.

Stage-5 Preparation of Cycloserine by the purification in IPA and water, followed by drying to yeiled desiredproduct.

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59). Sacrubitil Valsartan: Brief Manufacturing Process:

Stage-1

The process involves Boc deprotection followed by ester preparation of N-Boc biphenyl amino acid withthionyl chloride in the presence of ethanol solvent to give biphenyl amino acid ethyl ester hydrochloride,

Stage-2

which further reacting with succinic anhydride in the presence of triethylamine in dichloromethane solventyields Sacubitril, which reacting with sodium hydroxide followed by calcium chloride yields Sacubitril hemicalcium salt

60). Gatifiloxacin: Brief manufacturing process:

Stage-1:

In the first stage, the condensation of 2-methyl piperazine is carried out with 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid in presence of triethyl amine to form crude gatifloxacin.

Stage-2:

Crude gatifloxacin was then purified using methanol-water solvent mixture to form pure gatifloxacin (API).

61). Daclatasavir; Brief Manufacturing Process:

Step-1

The process involves bromination of compound (I) with bromine followed by replacement of bromine with N-boc-L-proline to yield compound (III).

Step-2

Compound (III) undergoes imidazole formation with ammonium acetate at elevated temperature to givecompound (IV).

Step-3

Compound (IV) after boc deprotection followed by reaction with N-(methoxycarbonyl)-L-valine furnishedDaclatasavir.

62). Dalfampyridine; Brief manufacturing process:

Stage-1

Isonicotinic acid reacts with Thionyl chloride to form acid chloride (DAL-1), further that is converted to methylester (DAL-2) in the presence of methanol, further which is converted to Isonicotinamide (DAL-3) in thepresence of methanolic ammonia

Stage-2

Isonicotinamide (DAL-3) reacts with sodium hypochlorite to form DAL-4 further that is converted to 4-Aminopyridine (DAL-5) in the presence of Sodium hydroxide at 50-55°C

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Stage-3

4- Aminopyridine (DAL-5) purified in Acetone and MTBE to get Dalfampridine API.

63). Brexpiprazole; Brief Manufacturing Process:

Step - 1: 7-Hydroxyquinolin-2-one (KSM-1) was reacted with 1-Bromo-4-chlorobutane (KSM-2) in the presence ofPotassium hydroxide by using Methanol as solvent at temp. 45-50 °C for 8 h to afford 7-(4-Chlorobutoxy)quinolin-2(1H)-one (Intermediate-1).

Step -2: 7-(4-chlorobutoxy) quinolin-2one (Intermediate-1) was further reacted with [1-(1-benzothiophen-4-yl)piperazine; KSM-3] in the presence of potassium carbonate and potassium iodide and DMF as solvent to resultBrexpiprazole API.

64). Flupiritine Maleate; Brief manufacturing process:

Stage-1

Condensation of 2-Amino-6-chloro-3-nitropyridine with 4-fluorobenzyl amine in the presence of triethylamineand water as a solvent to get N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diamine (FUP-1)

Stage-2

Reduction of N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diamine (FUP-1) in the presence of Raney Ni as acatalyst and 1,4 –dioxane as a solvent to get N6-(4-fluorobenzyl)pyridine-2,3,6-triamine (FUP-2),further it isreacts with ethylchloroformate to get flupirtine free base (FUP-3) , further which is reacts with maleic acid toget flupirtine maleate (FUP-4).

Stage-3

Flupirtine maleate (FUP-4) purified in methanol and water to get Flupirtine maleate API.

65). Omagrigliptin: Brief manufacturing process of Omarigliptin:

Stage-1:

Aminoketone (OMA-S1) is treated with Dimethylformamide dimethyl acetal in presence of THF as a solvent toget the OMA-1.

Stage-2:

OMA-1 is treated with hydrazine hydrate in presence of toluene as a solvent to get the OMA-2.

Stage-3:

OMA-2 is treated with p-toluenesulfonic acid in methanol and dichloromethane to get the OMA-3.

Stage-4:

OMA-3 is treated with methansulfonic acid presence of4-methyl THF and triethylamine to get the OMA-4.

Stage-5:

OMA-4 is treated with benzene sulfonic acid in presence of isopropyl acetate to get the OMA-5.

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Stage-6:

OMA-5 is coupled with OMA-S2 in presence of sodium triacetoxyborohydride and DMA to get the OMA-6.

Stage-7:

OMA-6 is treated with sulfuric acid in presence of DMA and ammonium hydroxide to get the Omarigliptin(OMA).

66). Clobazam EC; Brief Manufacturing Process:

Stage-1: The process involves nucloephilic aromatic substitution of chlorine atom with aniline at highertemperature to provide stage-1 material.

Stage-2: Reduction of stage-1 material with iron/raney-nickel under hydrogen atmosphere furnished stage-2material. Further, stage-2 material undergo acid-amine coupling with DCC to give stage-3 material.

Stage-3: After cyclization using NaH give stage-4 material.

Stage-4: followed by methylation with DMS furnished crude clobazam

Stage-5: which on purification provided pure Clobazam

67). Febuxostat: Brief Manufacturing Process:

Step - 1: 4-hydroxybenzenecarbothioamide (S1) reacts with Ethyl 2-chloro-3-oxobutanoate (S2) in presence of IPA toproduce the (INT-1). Intermediate (INT-1) in presence of HMTA and TFA to produce the (INT-2). Intermediate (INT-2) reacts with 1-Bromo-2-methylpropane (S3) in presence of DMF and K2CO3 to produce (INT-3).

Step – 2:Intermediate (INT-3) react with NH2OH.HCl in presence of formic acid and further hydrolysis with NaOHsolution to give (Febuxostat).

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Schematic of ETP cum Reverse Osmosis Plant

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MATERIAL SAFETY DATA SHEET1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION MSDS Name: N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamideCAS Number: 171887-03-9Catalog Numbers: AK-27115 For R&D use only.Company Identification: Ark Pharm, Inc.1840 Industrial Drive, Suite 280Libertyville, IL 60048 USATel: 847-367-3680 Fax: 847-367-3681

2. COMPOSITION, INFORMATION ON INGREDIENTS

Molecular Formula: C5H4Cl2N4OMolecular Weight: 207.017

3. HAZARDS IDENTIFICATIONEMERGENCY OVERVIEW

3.1 Classification of the substance or mixtureClassification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]Acute toxicity, Oral (Category 4)Skin irritation (Category 2)Eye irritation (Category 2)Specific target organ toxicity - single exposure (Category 3)Classification according to EU Directives 67/548/EEC or 1999/45/ECHarmful if swallowed. Irritating to eyes, respiratory system and skin. 3.2 Label elementsLabelling according Regulation (EC) No 1272/2008 [CLP]

PictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.Precautionary statement(s)P261 Avoid breathing dust.P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several

minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.

Supplemental Hazard Statements NoneAccording to European Directive 67/548/EEC as amended

Ark Pharm arkpharminc.comVerison 2.0

AK-27115 N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide

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LenovoLap

Typewritten text

Annexure- 9

Hazard symbol(s)

R-phrase(s)R22R36/37/38

Harmful if swallowed.Irritating to eyes, respiratory system and skin.

S-phrase(s)S26 In case of contact with eyes, rinse

immediately with plenty of water and seek medicaladvice.

S36/37 Wear suitable protective clothing and gloves.3.3 Other hazards None

4. FIRST AID MEASURES

Eyes: Flush eyes with plenty of water occasionally lifting the upper and lower lids. Get medical aid.Skin: Get medical aid. Flush skin with plenty of water while removing contaminated clothing and shoes.Ingestion: Get medical aid. Wash mouth out with water.Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificialrespiration. If breathing is difficult, give oxygen.

5. FIRE FIGHTING MEASURES

General Information: As in any fire, wear a self-contained breathing apparatus and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide or chemical foam.

6. ACCIDENTAL RELEASE MEASURES

General Information: Use proper personal protective equipment.Spills/Leaks: Vacuum or sweep up material and place into suitable disposalcontainer. Avoid generating dustyconditions.

7. HANDLING AND STORAGE

Handling: Avoid breathing dust, vapor, mist or gas. Avoid contact with eyes, skin.Storage: Storage temperature: 2 - 4 °C and Keep container tightly closed in a dry and well-ventilated place.

8. EXPOSURE CONTROLS, PERSONAL PROTECTION

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facilityand safety shower. Use adequate ventilation to keep airborne concentrations low.Personal Protective EquipmentEyes: Wear chemical safety goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Wear appropriate respirators where necessary.

9. PHYSICAL AND CHEMICAL PROPERTIES

Boiling Point 554.77 °C at 760 mmHg Melting Point No data available. Solubility in water Slightly soluble.



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Vapor Pressure No data available. Vapor Density No data available.

10. STABILITY AND REACTIVITY

Chemical Stability: This product is relatively unstable under normal temperature.Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous combustion or Decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, andhydrogen chloride.

11. TOXICOLOGICAL INFORMATION

May be toxic by inhalation, in contact with skin and if swallowed.

12. ECOLOGICAL INFORMATION

Not available.

13. DISPOSAL CONSIDERATIONS

Dispose of in a manner consistent with federal, state, and local regulations.

14. TRANSPORT INFORMATION

Not available.

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.Safety, health and environmental regulations/legislation specific for the substance or mixture:Not available.Chemical Safety Assessment:Not available.

16. ADDITIONAL INFORMATION

The above information pertains to this product as currently formulated, and is based on the informationavailable at this time. Addition of reducers or other additives to this product may substantially alter thecomposition and hazards of the product. Since conditions of use are outside our control, we make nowarranties, express or implied, and assume no liability in connection with any use of this information.

Revision Date 12/30/2011 Print Date 12/07/2012



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SAFETY DATA SHEET

1. IdentificationProduct Name Cyclopropylamine

Cat No. : AC263680000; AC263680025; AC263680250; AC263681000;AC263685000

Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against No Information availableDetails of the supplier of the safety data sheet

2. Hazard(s) identificationClassification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal WordDanger

Hazard StatementsHighly flammable liquid and vaporHarmful if swallowedHarmful in contact with skinHarmful if inhaledCauses severe skin burns and eye damageCauses serious eye damage

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Creation Date 22-Sep-2009

Acute oral toxicity Category 4

CompanyFisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100

Acute dermal toxicity Category 4

Revision Date 10-Feb-2015

Acute Inhalation Toxicity - Vapors Category 4

Entity / Business NameAcros OrganicsOne Reagent LaneFair Lawn, NJ 07410

Skin Corrosion/irritation Category 1 B

Emergency Telephone NumberFor information US call: 001-800-ACROS-01/ Europe call: +32 14 57 52 11Emergency Number US:001-201-796-7100 /Europe: +32 14 57 52 99CHEMTREC Tel. No.US:001-800-424-9300 /Europe:001-703-527-3887

Serious Eye Damage/Eye Irritation Category 1

Revision Number 1

Flammable liquids Category 2

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Precautionary StatementsPreventionKeep away from heat/sparks/open flames/hot surfaces. - No smokingKeep container tightly closedGround/bond container and receiving equipmentUse explosion-proof electrical/ventilating/lighting/equipmentUse only non-sparking toolsTake precautionary measures against static dischargeWear protective gloves/protective clothing/eye protection/face protectionWash face, hands and any exposed skin thoroughly after handlingDo not eat, drink or smoke when using this productAvoid breathing dust/fume/gas/mist/vapors/sprayUse only outdoors or in a well-ventilated areaResponseCall a POISON CENTER or doctor/physician if you feel unwellInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingCall a POISON CENTER or doctor/physician if you feel unwellSkinImmediately call a POISON CENTER or doctor/physicianWash contaminated clothing before reuseIF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/showerEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingImmediately call a POISON CENTER or doctor/physicianIngestionIF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwellRinse mouthDo NOT induce vomitingFireExplosion risk in case of fireFight fire with normal precautions from a reasonable distanceEvacuate areaStorageStore locked upStore in a closed containerStore in a well-ventilated place. Keep coolDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) None identified

3. Composition / information on ingredients

Component CAS-No Weight %Cyclopropanamine 765-30-0 99

4. First-aid measures

Eye Contact Immediate medical attention is required. Rinse immediately with plenty of water, also under

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Cyclopropylamine Revision Date 10-Feb-2015

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the eyelids, for at least 15 minutes.

Skin Contact Immediate medical attention is required. Wash off immediately with plenty of water for atleast 15 minutes.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouthresuscitation if victim ingested or inhaled the substance; induce artificial respiration with arespiratory medical device. Immediate medical attention is required.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms/effects Breathing difficulties. Causes burns by all exposure routes. . Inhalation of high vaporconcentrations may cause symptoms like headache, dizziness, tiredness, nausea andvomiting: Product is a corrosive material. Use of gastric lavage or emesis iscontraindicated. Possible perforation of stomach or esophagus should be investigated:Ingestion causes severe swelling, severe damage to the delicate tissue and danger ofperforation

Notes to Physician Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media Water spray. Carbon dioxide (CO 2). Dry chemical. chemical foam. Cool closed containers

exposed to fire with water spray.

Unsuitable Extinguishing Media No information available

Flash Point -25 °C / -13 °FMethod - No information available

Autoignition Temperature 275 °C / 527 °FExplosion Limits

Upper No data availableLower No data availableSensitivity to Mechanical Impact No information availableSensitivity to Static Discharge No information available

Specific Hazards Arising from the ChemicalFlammable. Vapors may travel to source of ignition and flash back. Containers may explode when heated. Vapors may formexplosive mixtures with air.

Hazardous Combustion ProductsNitrogen oxides (NOx) Carbon monoxide (CO) Carbon dioxide (CO2)Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Remove all sources of ignition. Take precautionary measures against static discharges.

Use personal protective equipment.Environmental Precautions See Section 12 for additional ecological information.

Methods for Containment and CleanUp

Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder,sawdust). Keep in suitable, closed containers for disposal. Remove all sources of ignition.Use spark-proof tools and explosion-proof equipment.

7. Handling and storage

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Instability1

Cyclopropylamine

Physical hazardsN/A


Health3

Flammability3

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Handling Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing. Takeprecautionary measures against static discharges. Use only in area provided withappropriate exhaust ventilation. Use explosion-proof equipment. Use only non-sparkingtools. Contents may develop pressure upon prolonged storage. Keep away from openflames, hot surfaces and sources of ignition. To avoid ignition of vapors by static electricitydischarge, all metal parts of the equipment must be grounded. Wear personal protectiveequipment.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed. Keep awayfrom heat and sources of ignition. Flammables area. Keep away from heat/sparks/openflames/hot surfaces. - No smoking. Keep container tightly closed in a dry and well-ventilatedplace.

8. Exposure controls / personal protectionExposure Guidelines This product does not contain any hazardous materials with occupational exposure limits

established by the region specific regulatory bodies.

9. Physical and chemical propertiesPhysical State LiquidAppearance Light yellowOdor Ammonia-likeOdor Threshold No information availablepH No information availableMelting Point/Range -50 °C / -58 °FBoiling Point/Range 49 - 50 °C / 120.2 - 122 °F @ 760 mmHgFlash Point -25 °C / -13 °FEvaporation Rate No information availableFlammability (solid,gas) Not applicableFlammability or explosive limits

Upper No data availableLower No data available

Vapor Pressure 450 mbar @ 20 °CVapor Density 2.0 (Air = 1.0)Relative Density 0.824Solubility No information availablePartition coefficient; n-octanol/water No data availableAutoignition Temperature 275 °C / 527 °FDecomposition Temperature No information availableViscosity No information available

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Cyclopropylamine

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described byOSHA's eye and face protection regulations in 29 CFR 1910.133 or European StandardEN166.

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stationsand safety showers are close to the workstation location. Use explosion-proofelectrical/ventilating/lighting/equipment.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.


Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European StandardEN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator ifexposure limits are exceeded or if irritation or other symptoms are experienced.

Personal Protective Equipment

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

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Molecular Formula C3 H7 NMolecular Weight 57.09

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Hygroscopic.

Conditions to Avoid Keep away from open flames, hot surfaces and sources of ignition. Incompatible products.Exposure to moist air or water.

Incompatible Materials Acids, Strong oxidizing agents, Acid anhydrides, Acid chlorides, Carbon dioxide (CO2)

Hazardous Decomposition Products Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological informationAcute Toxicity

Product InformationDermal LD50 Category 4. ATE = 1000 - 2000 mg/kg.Vapor LC50 Category 4. ATE = 10 - 20 mg/l.Component Information

Component LD50 Oral LD50 Dermal LC50 InhalationCyclopropanamine 445 mg/kg ( Rat ) Not listed Not listed

Toxicologically SynergisticProducts

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Causes skin burns Causes eye burns

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA MexicoCyclopropanamine 765-30-0 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects Not mutagenic in AMES Test

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None knownSTOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute anddelayed

Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,tiredness, nausea and vomiting: Product is a corrosive material. Use of gastric lavage oremesis is contraindicated. Possible perforation of stomach or esophagus should beinvestigated: Ingestion causes severe swelling, severe damage to the delicate tissue anddanger of perforation

Endocrine Disruptor Information No information available

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Other Adverse Effects The toxicological properties have not been fully investigated. See actual entry in RTECS forcomplete information.

12. Ecological informationEcotoxicity Do not empty into drains.

Persistence and Degradability Persistence is unlikely based on information available.Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

13. Disposal considerationsWaste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a

hazardous waste. Chemical waste generators must also consult local, regional, andnational hazardous waste regulations to ensure complete and accurate classification.

14. Transport informationDOT

UN-No UN3286Proper Shipping Name AMINES, FLAMMABLE, CORROSIVE, N.O.S.Proper technical name (CYCLOPROPYLAMINE)Hazard Class 3Subsidiary Hazard Class 8Packing Group II

TDG UN-No UN3286Proper Shipping Name AMINES, FLAMMABLE, CORROSIVE, N.O.S.Hazard Class 3Subsidiary Hazard Class 8Packing Group II

IATA UN-No 2733Proper Shipping Name AMINES, FLAMMABLE, CORROSIVE, N.O.S.*Hazard Class 3Subsidiary Hazard Class 8Packing Group II

IMDG/IMO UN-No 2733Proper Shipping Name AMINES, FLAMMABLE, CORROSIVE, N.O.S.Hazard Class 3Subsidiary Hazard Class 8Packing Group II

15. Regulatory information

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLCyclopropanamine X - X 212-142-2 - X X X X X

Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.

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S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313 Not applicable

SARA 311/312 Hazardous CategorizationAcute Health Hazard YesChronic Health Hazard NoFire Hazard YesSudden Release of Pressure Hazard NoReactive Hazard No

Clean Water Act Not applicable

Clean Air Act Not applicable

OSHA Occupational Safety and Health AdministrationNot applicable

CERCLANot applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals

State Right-to-Know Not applicable

U.S. Department of Transportation

Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N

U.S. Department of Homeland SecurityThis product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade No information available

CanadaThis product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) andthe MSDS contains all the information required by the CPR

WHMIS Hazard Class B2 Flammable liquidD1B Toxic materialsE Corrosive material

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Revision Date 10-Feb-2015Cyclopropylamine

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______________________________________________________________________________________________

16. Other informationPrepared By Regulatory Affairs

Thermo Fisher ScientificEmail: [email protected]

Creation Date 22-Sep-2009Revision Date 10-Feb-2015Print Date 10-Feb-2015Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard

replacing the current legislation under 29 CFR 1910.1200 to align with the GloballyHarmonized System of Classification and Labeling of Chemicals (GHS)

DisclaimerThe information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at thedate of its publication. The information given is designed only as a guide for safe handling, use, processing, storage,transportation, disposal and release and is not to be considered as a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterial or in any process, unless specified in the text.

End of SDS

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Revision Date 10-Feb-2015Cyclopropylamine

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SAFETY DATA SHEETCreation Date 03-Nov-2010 Revision Date 09-Jul-2014 Revision Number 1

1. IdentificationProduct Name Succinic acid

Cat No. : A294-500; BP336-500; S80210

Synonyms Butanedioic acid




Label Elements

Signal WordWarning

Hazard StatementsCauses skin irritationCauses serious eye irritationMay cause respiratory irritation


Emergency Telephone NumberCHEMTRECÒ, Inside the USA: 800-424-9300CHEMTRECÒ, Outside the USA: 001-703-527-3887

Skin Corrosion/irritation Category 2Serious Eye Damage/Eye Irritation Category 2

______________________________________________________________________________________________

Specific target organ toxicity (single exposure) Category 3Target Organs - Respiratory system.

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______________________________________________________________________________________________Succinic acid Revision Date 09-Jul-2014

Precautionary StatementsPreventionWash face, hands and any exposed skin thoroughly after handlingWear protective gloves/protective clothing/eye protection/face protectionAvoid breathing dust/fume/gas/mist/vapors/sprayUse only outdoors or in a well-ventilated areaInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingCall a POISON CENTER or doctor/physician if you feel unwellSkinIF ON SKIN: Wash with plenty of soap and waterIf skin irritation occurs: Get medical advice/attentionTake off contaminated clothing and wash before reuseEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIf eye irritation persists: Get medical advice/attentionStorageStore in a well-ventilated place. Keep container tightly closedStore locked upDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) None identified


Component CAS-No Weight %Succinic acid 110-15-6 >95


Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.Obtain medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Obtain medical attention.

Ingestion Do not induce vomiting. Obtain medical attention.

Most important symptoms/effects No information available.Notes to Physician Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media

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Water spray. Carbon dioxide (CO 2). Dry chemical. chemical foam.


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Flash Point 206 °C / 402.8 °F

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Method - No information available

Autoignition Temperature 630 °C / 1166 °F

Explosion LimitsUpper No data availableLower No data availableSensitivity to Mechanical Impact No information availableSensitivity to Static Discharge No information available

Specific Hazards Arising from the ChemicalKeep product and empty container away from heat and sources of ignition.

Hazardous Combustion ProductsCarbon monoxide (CO) Carbon dioxide (CO2)Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Use personal protective equipment. Ensure adequate ventilation. Avoid dust formation.Environmental Precautions Should not be released into the environment.


Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dustformation.

7. Handling and storageHandling Wear personal protective equipment. Ensure adequate ventilation. Avoid dust formation. Do

not breathe dust. Avoid contact with skin, eyes and clothing. Wash hands before breaksand immediately after handling the product.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed.



9. Physical and chemical propertiesPhysical State Powder Solid

Health2

Flammability1

Instability0

Physical hazardsN/A

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stationsand safety showers are close to the workstation location.

Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by

OSHA's eye and face protection regulations in 29 CFR 1910.133 or European StandardEN166.

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Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.Respiratory Protection

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Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European StandardEN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator ifexposure limits are exceeded or if irritation or other symptoms are experienced.


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Appearance WhiteOdor OdorlessOdor Threshold No information availablepH 2.7 0.1M aq.solMelting Point/Range 185 - 190 °C / 365 - 374 °FBoiling Point/Range 235 °C / 455 °FFlash Point 206 °C / 402.8 °FEvaporation Rate No information availableFlammability (solid,gas) No information availableFlammability or explosive limits


Vapor Pressure 0.0022 mmHg @ 19 °CVapor Density No information availableRelative Density 1.56Solubility No information availablePartition coefficient; n-octanol/water No data availableAutoignition Temperature 630 °C / 1166 °FDecomposition temperature > 235°CViscosity No information availableMolecular Formula C4 H6 O4Molecular Weight 118.09



Stability Stable under normal conditions.

Conditions to Avoid Avoid dust formation. Incompatible products. Excess heat.

Incompatible Materials Bases, Reducing agents

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)




Component InformationToxicologically SynergisticProducts



Irritation Irritating to eyes, respiratory system and skin



Component CAS-No IARC NTP ACGIH OSHA MexicoSuccinic acid 110-15-6 Not listed Not listed Not listed

______________________________________________________________________________________________

Not listed Not listedMutagenic Effects Mutagenic effects have occurred in humans.

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STOT - single exposure Respiratory systemSTOT - repeated exposure None known


Symptoms / effects,both acute and delayed





Persistence and Degradability No information available

Bioaccumulation/ Accumulation No information available.

Mobility No information available.



14. Transport informationDOT Not regulatedTDG Not regulatedIATA Not regulatedIMDG/IMO Not regulated



Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLSuccinic acid X X - 203-740-4 - X X X X X

Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substance

______________________________________________________________________________________________

R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).

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Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.

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SARA 311/312 Hazardous CategorizationAcute Health Hazard YesChronic Health Hazard NoFire Hazard NoSudden Release of Pressure Hazard NoReactive Hazard No













WHMIS Hazard Class D2B Toxic materials

16. Other informationPrepared By

______________________________________________________________________________________________

Regulatory AffairsThermo Fisher ScientificEmail: [email protected]

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Creation Date 03-Nov-2010Revision Date 09-Jul-2014

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Print Date 09-Jul-2014Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard


______________________________________________________________________________________________


End of SDS

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Material Safety Data SheetSodium carbonate MSDS

Section 1: Chemical Product and Company Identification

Product Name: Sodium carbonate

Catalog Codes: SLS3481, SLS1264, SLS4105, SLS1894,SLS3316

CAS#: 497-19-8

RTECS: VZ4050000

TSCA: TSCA 8(b) inventory: Sodium carbonate

CI#: Not available.

Synonym: Crystal Carbonate, Disodium Carbonate, SalSoda, Soda Asha, Washing Soda

Chemical Name: Sodium Carbonate, Anhydrous

Chemical Formula: Na2-C-O3

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Sodium carbonate 497-19-8 100

Toxicological Data on Ingredients: Sodium carbonate: ORAL (LD50): Acute: 4090 mg/kg [Rat]. 6600 mg/kg [Mouse]. DUST(LC50): Acute: 2300 mg/m 2 hours [Rat]. 1200 mg/m 2 hours [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation(lung irritant).

Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance maybe toxic to upper respiratory tract, skin, eyes. Repeated or prolonged exposure to the substance can produce target organsdamage.

Section 4: First Aid Measures

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http://www.sciencelab.com/

p. 2

Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation: Not available.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Non-flammable.

Auto-Ignition Temperature: Not applicable.

Flash Points: Not applicable.

Flammable Limits: Not applicable.

Products of Combustion: Emits Na2O fumes when heated to decompositon.

Fire Hazards in Presence of Various Substances: Not applicable.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions: Not applicable.

Special Remarks on Fire Hazards:Sodium carbonate can ignite and burn fiercely in contact with fluoride. Sodium Carbonate in contact with fluorine decomposedat ordinary temperature with incandescence.

Special Remarks on Explosion Hazards:Reacts explosively with red-hot aluminum metal. Sodium carbonate + ammonia in arabic gum solution will explode.

Section 6: Accidental Release Measures

Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue witha dilute solution of acetic acid. Finish cleaning by spreading water on the contaminated surface and dispose of according tolocal and regional authority requirements.

Large Spill:Use a shovel to put the material into a convenient waste disposal container. Neutralize the residue with a dilute solutionof acetic acid. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitarysystem.

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Section 7: Handling and Storage

Precautions:Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitablerespiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact withskin and eyes. Keep away from incompatibles such as acids.

Storage:Hygroscopic. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 24°C (75.2°F).Hygroscopic

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.

Personal Protection:Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid powder.)

Odor: Odorless.

Taste: Alkaline.

Molecular Weight: 105.99 g/mole

Color: White.

pH (1% soln/water): 11.5 [Basic.]

Boiling Point: Not available.

Melting Point: 851°C (1563.8°F)

Critical Temperature: Not available.

Specific Gravity: Density: 2.532 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water.

Solubility:

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p. 4

Soluble in hot water, glycerol. Partially soluble in cold water. Insoluble in acetone, alcohol.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Incompatible materials, moisture

Incompatibility with various substances:Reactive with acids. Slightly reactive to reactive with moisture.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity:Hygroscopic. Combines with water with evolution of heat. Incompatible with phosphorus pentoxide, lithium, fluorine, fluoride,ammonia + silver nitrate, 2,4,6-trinitrotoluene, ammonia, acids, sodium sulfide + water, hydrogen peroxide, red hot alumiummetal, sodium sulfide, zinc, calcium hydroxide. Sodium Carbonate is decomposed by acids with effervescence. Reactsviolently with F2, Lithium, and 2,4,6-trinitrotoluene. Sodium begins to decompose at 400 C to evolve CO2.

Special Remarks on Corrosivity: Hot concentrated solutions of sodium carbonate are mildly corrosive to steel.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 4090 mg/kg [Rat]. Acute toxicity of the dust (LC50): 1200 mg/m3 2 hours [Mouse].

Chronic Effects on Humans: May cause damage to the following organs: upper respiratory tract, skin, eyes.

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).

Special Remarks on Toxicity to Animals: LDL (Lowest Published Lethal Dose) [Man] - Route: Oral; Dose: 714 mg/kg

Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects based on animal test data

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation with possible burns depending on the concentration, site (abradedor intact skin), and duration of exposure. Eyes: Causes eye irritation and possible burns. Concentrated solutions may causepermanent corneal injury (permanent corneal opacity). Ingestion: Sodium carbonate ingestion may cause irritation of thedigestive tract resulting in nausea, vomiting, diarrhea, thirst, abdominal pain depending on concentration and amount ingested.May also affect the cardiovascular system . Inhalation: Dust may cause respiratory tract and mucous membrane irritationwith coughing and shortness of breath (dyspnea), pulmonary edema. Chronic Potential Health Effects: Chronic inhalationmay result in decreased pulmonary function, nasal congestion, nosebleeds, perforation of the nasal septum. Other effectsof chronic exposure are skin (dermatitis and ulceration), and gastrointestinal complaints. However, the effects of chronicexposure seem to be reversible if exposure is decreased.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

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Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Sodium carbonate

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): CLASS D-2B: Material causing other toxic effects (TOXIC).

DSCL (EEC):R36/37/38- Irritating to eyes, respiratory system and skin. S22- Do not breathe dust. S26- In case of contact with eyes, rinseimmediately with plenty of water and seek medical advice.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 0

Reactivity: 1

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 0

Reactivity: 1

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

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p. 6

Created: 10/10/2005 08:26 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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p. 1

3 0 0

He a lt h

Fire

Re a c t iv it y


2

3

0

J

Material Safety Data SheetTriethyl Orthoformate MSDS


Product Name: Triethyl Orthoformate

Catalog Codes: SLT1003

CAS#: 122-51-0

RTECS: RM6475000

TSCA: TSCA 8(b) inventory: Triethyl Orthoformate

CI#: Not available.

Synonym: Aethon, Ethone,; Ethyl Orthoformate;Triethoxymethane

Chemical Name: Orthoformic Acid, triethyl ester

Chemical Formula: C7-H16-O3









Composition:


Triethyl Orthoformate 122-51-0 100

Toxicological Data on Ingredients: Triethyl Orthoformate: ORAL (LD50): Acute: 7060 mg/kg [Rat].


Potential Acute Health Effects:Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant,permeator).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition.



Page 75 of 485


p. 2


Serious Skin Contact: Not available.


Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.




Flammability of the Product: Flammable.

Auto-Ignition Temperature: Not available.

Flash Points: CLOSED CUP: 30°C (86°F). OPEN CUP: 35°C (95°F).

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.


Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.


Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.

Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed.


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Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keepaway from incompatibles such as oxidizing agents.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.


Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator orequivalent.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.



Physical state and appearance: Liquid.

Odor: Pungent.

Taste: Not available.


Color: Clear Colorless.

pH (1% soln/water): Not available.

Boiling Point: 143°C (289.4°F)

Melting Point: -76°C (-104.8°F)


Specific Gravity: 0.891 (Water = 1)

Vapor Pressure: 0.4 kPa (@ 20°C)

Vapor Density: 5.11 (Air = 1)





Dispersion Properties: See solubility in water, diethyl ether.

Solubility:Soluble in cold water, diethyl ether. Solubility in Water: 1.35 g/l (decomposes). Soluble in alcohol.

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Conditions of Instability: Heat, ingnition sources (flames, sparks, static), incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents.

Corrosivity: Not available.

Special Remarks on Reactivity:Moisture sensitive. Incompatible with oxidizing such as perchlorates, permanganates, peroxides, chlorates, nitrates, chlorine,bromine, fluorine.

Special Remarks on Corrosivity: Not available.



Routes of Entry: Absorbed through skin. Eye contact.

Toxicity to Animals: Acute oral toxicity (LD50): 7060 mg/kg [Rat].

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator).

Special Remarks on Toxicity to Animals:Lethal Dose/Conc 50% kill: LD50 [Rabbit] - Route: Skin; Dose: 20 ml/kg LD50 [Guinea Pig] - Route: Skin; Dose: >10ml/kg

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. It may be absorbed through the skin. Eyes: Causes eyeirritaiton. Inhalation: May cause respiratory tract and mucous membrane irritation. Vapors may cause dizziness or suffocation.Ingestion: May cause digestive tract irritation.





Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.





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DOT Classification: CLASS 3: Flammable liquid.

Identification: : Ethyl Orthoformate UNNA: 2524 PG: III

Special Provisions for Transport: Not available.


Federal and State Regulations:Pennsylvania RTK: Triethyl Orthoformate Massachusetts RTK: Triethyl Orthoformate New Jersey: Triethyl Orthoformate TSCA8(b) inventory: Triethyl Orthoformate

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.


WHMIS (Canada):Classification of this product has not yet been validated by the Service du repertoire toxicologique.

DSCL (EEC):R10- Flammable. R36/38- Irritating to eyes and skin. S16- Keep away from sources of ignition - No smoking. S26- In case ofcontact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39- Wear suitable gloves and eye/faceprotection.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0

Personal Protection: j


Health: 0

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Not applicable. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriaterespirator when ventilation is inadequate. Splash goggles.




Created: 10/10/2005 12:08 AM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information for

Page 79 of 485

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their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

Page 80 of 485

MATERIAL SAFETY DATA SHEET

Hydrochloric acid 0.5 Normal in IPA

SECTION 3 MIXTURE COMPONENTS

SECTION 1 . Product and Company Idenfication

Product Code:

Product Name and Synonym:

4191


SECTION 2 HAZARD IDENTIFICATION

Health: 2

Flammability: 3

Reactivity: 0

Hazard Rating:

Least Slight Moderate High Extreme

0 1 2 3 4

NA=Not Applicable NE=Not Established

Science Stuff

1104 Newport Ave

Austin, TX 78753

(512) 837-6020

Material Uses:

Manufacturer:

Entry Date : 6/5/2013

Chemtrec 800-424-9300 Canutec 613-996-6666

24 Hour Emergency Assistance :

Print Date: 6/6/2013

Component

Percent

Comp. DimensionSARA 313 CAS Number

Exposure

Limits

SECTION 4 FIRST AID MEASURES

SECTION 5 FIRE FIGHTING MEASURES

Fire Extinguisher Type: Any means suitable for extinguishing surrounding fire

Fire / Explosion Hazards:Vapor may travel considerable distance to

Keep away from heat and ignition sources. Harmful if swallowed. Avoid breathing vapors. Use with adequate ventilation. Avoid contact with eyes, skin, and clothes. Wash thoroughly after handling. Keep container closed.

FIRST AID: SKIN: In case of contact, immediately flush skin with water for at least 15 minutes while removing contaminated clothing and shoes. Thoroughly clean clothing and shoes before reuse. If symptoms persist, seek medical attention.

EYES: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid. INHALATION: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen

INGESTION: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Keep away from heat and ignition sources. Harmful if swallowed. Avoid breathing vapors. Use with adequate ventilation. Avoid contact with eyes, skin, and clothes. Wash thoroughly after handling. Keep container closed.

Hydrochloric Acid 4.2% V/VCAS# 7647-01-0

OSHA PEL (C) 5 ppm, (C) 7 mg/mƒ

Isopropyl Alcohol (2-propanol)

Balance V/VCAS# 67-63-0 OSHA TWA 400 ppm, STEL 500 ppm

Page 81 of 485


Fire Fighting Procedure: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and clothing.

source of ignition and flash back.

SECTION 6 ACCIDENTAL RELEASE MEASURES

Eliminate Ignition Sources. Neutralize with: Soda lime, soda ash. Absorb with vermiculite or other inert material. Place in container.

SECTION 8 EXPOSURE CONTROLS/PERSONAL PROTECTION

Respiratory Protection: NIOSH/MSHA-approved respirator

Mechanical

Local ExhaustVentilation

Protective Gloves: Gloves to prevent skin exposure as rubber or vinyl

Eye Protection: Splash Goggles

Other Protective Equipment: Wear appropriate clothing to prevent skin exposure

Store in a cool dry well ventalated area. Keep away from heat and flame. Do not get in eyes, on skin, or on clothing.

SECTION 7 HANDLING AND STORAGE

SECTION 9 PHYSICAL AND CHEMICAL PROPERTIES

Melting Point: ~-89° C

Boiling Point: ~+82° C

Vapor Pressure: ~33 @25° c

Vapor Density: ~2.1 (air = 1)

Solubility in Water: Soluble

Appearance /Odors: Clear water white / IPA smell

Flash Point: ~12° C (Closed Cup)

Specific Gravity: 0.79

Percent Volatile by Volume: 100%

Evaporation Rate Information not available

Auto Ignition Temp 399° C

Lower Flamm. Limit in Air 2%

Upper Flamm. Limit in Air 12%

Evaporation Standard

SECTION 10 STABILITY AND REACTIVITY INFORMATION

Stability: Stable

Conditions to Avoid: Avoid heat and ignition sources

Materials to Avoid: Metals, strong bases, amines, strong oxidizers

Hazardous DecompositionProducts:

Carbon Oxides

Hazardous polymerization: Will Not Occur

Conditions to Avoid: None known

Page 2 of 5

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SECTION 11 Toxicological Information

SECTION 12 Ecological Information

United States

Product/ingredient name – Isopropyl Alcohol

Test Result Route Species LD50 12800 mg/kg Dermal RabbitLD50 2735 mg/kg Dermal RatIntraperitonealLD50 1088 mg/kg Intravenous RatLD50 5045 mg/kg Oral RatLD50 5000 mg/kg Oral RatLD50 6410 mg/kg Oral RabbitIntraperitoneal LC50 16000 ppm Inhalation Gas Rat

Carcinogenicity Classification

Product/ingredient name: Isopropyl AlcoholACGIH: A4IARC: 3EPA: -NIOSH: -NTP: -OSHA: -

Hydrochloric AcidLD50 900 mg/kg Oral RabbitLC50 1108 ppm Inhalation Vapor Mouse

Carcinogenic effects: No known significant effects or critical hazards. Mutagenic effects: No known significant effects or critical hazards. Teratogenicity/Reproductive toxicity: No known significant effects or critical hazards.

Ecotoxicity data - United States

Result Species ExposureAcute EC50 10000 mg/L Fish 48 hoursAcute LC50 10400 mg/L Fish 96 hoursAcute LC50 11130 mg/L Fish 96 hoursAcute LC50 9640 mg/L Fish 96 hoursAcute LC50 6550 mg/L Fish 96 hoursAcute LC50 <1400 mg/L Fish 96 hours

Result: Acute LC50<1400000 ug/L Species: Fish – Western mospuitofish–Gambusia affinis – 20 to 30 mmExposure: 96 hours

Result: Acute LC50 1400000 to 1950000ug/L Marine waterSpecies: Crustaceans – Common shrimp, sand shrimp – Crangon crangonExposure: 48 hours

Result: Acute LC50 11130000ug/L Fresh waterSpecies: Pimephales promelas – Juvenile (Fledgling, Hatchling, Weanling) 4 to 8 weeks1.1to 3.1 cmExposure: 96 hours Result: Acute LC50 10400000 to 1060000000 ug/LFresh waterSpecies: Fish – Fathead minnow-Pimephales promelas29 days – 20 mm-0.103 gExposure: 96 hours

Result: Acute LC 50 6550000to 7450000 ug/LSpecies: Fish – Fathead minnow – Pimephales promelas – 31 days – 17.4 mm – 0.082 gExposure: 96 hours

Result: Acute LC50 4200000 ug/L Fresh waterSpecies: Fish – Harlequinfish, red rasbora – Rasbora – heteromorpha – 1 to 3 cmExposure: 96 hours

Page 3 of 5

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SECTION 13 Disposal Considerations

SECTION 14 Transport Information

SECTION 15 Regulatory Information

Environmental effects: No known significant effects or critical hazards.Other adverse effects: No known significant effects or critical hazards.

The information presented only applies to the material as supplied. The identification based on characteristic(s) or listing may not apply if the material has been used or otherwise contaminated. It is the responsibility of the waste generator to determine the toxicity and physical properties of the material generated to determine the proper waste identification and disposal methods in compliance with applicable regulations. Disposal should be in accordance with applicable regional, national and local laws and regulations.

--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Isopropyl Alcohol (67-63-0) Yes Yes Yes Yes Water (7732-18-5) Yes Yes Yes Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil. ----------------------------------------------- ----- --- ---- ----- Isopropyl Alcohol (67-63-0) Yes Yes No Yes Water (7732-18-5) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg. ----------------------------------------- --- ----- ---- -------------- Isopropyl Alcohol (67-63-0) No No Yes No Water (7732-18-5) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Isopropyl Alcohol (67-63-0) No No No Water (7732-18-5) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: NoSARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: NoReactivity: No (Mixture / Liquid)

Australian Hazchem Code: 2[S]2 Poison Schedule: None allocated. Hydrochloric Acid:

United States inventory (TSCA 8b): listedTSCA (Toxic Substance Control Act): This product is listed on the TSCA Inventory.SARA 302/304/311/312 extremely hazardous substances: Hydrochloric AcidSARA 302/304 emergency planning and notifications: Hydrochloric AcidSARA 302/304/311/312 hazardous chemicals: Hydrochloric AcidSARA 311/312 MSDS distribution- Chemical inventory- hazard identification: Hydrochloric Acid Immediate (acute) health hazard, Delayed (chronic) health hazard Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: Hydrochloric AcidClean Air Act (CAA) 112 accidental release prevention: No products were foundClean Air Act (CAA) 112 regulated flammable substance: No products were found.Clean Air Act (CAA) 112 regulated toxic substance: No products were found

DEA List l Chemicals : not listed

DOT Classification: UN2924, Flammable Liquid, Corrosive, n.o.s. (Isopropanol, Hydrochloric acid), 3, (8), PG II

DOT Regulations may change from time to time. Please consult the most recent D.O.T. regulations.

Page 4 of 5

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SECTION 16 Additional Information

(Precursor Chemicals) DEA List ll Chemicals : listed(essential Chemicals)

SARA 313Form R – Reporting Requirements: Hydrochloric Acid CAS number : 7647-01-0 Concentration : 100

Supplier notification : Hydrochloric Acid CAS number : 7647-01-0 Concentration : 100

SARA 313 notifications must not be detached from the MSDS and any copying and redistribution of the MSDS shall include copying and redistribution of the notice attached to copies of the MSDS subsequently redistributed.

Massachusetts Substance : This material is listed.New Jersey Hazardous Substances : This material is listed.New York Acutely Hazardous Substances : This material is listed.Pennsylvania RTK Hazardous Substances : This material is listed.CanadaWHMIS (Canada) : Class D-1A: Material causing immediate and serious toxic effects (Very toxic)Class E: Corrosive material

Canadian lists :CEPA Toxic Substance: This material is not listed.Canadian ARET: This material is not listed.Canadian NPRI: This material is listed.Alberta Designated Substances: This material is not listed.Ontario Designated Substances: This material is not listed.Quebec Designated Substances: This material is not listed.CEPA DSL/ CEPA NDSL : CEPA DSL:This material is listed or exempted.This product has been classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.

The information herein is believed to be accurate and is offered in good faith for the user's consideration and investigation. No warranty either expressed or implied is made for the completeness or accuracy of the information whether originating from the above mentioned company or not. Users of this material should satisfy themselves by independent investigation of current scientific and medical knowledge that the material can be used safely.

Health Reactivity

Flammability

NFPARevisions

0.1 Revised DOT to add Class 8 sub LS

0.29/28/2011 Revised to 16 sec LS

Page 5 of 5

Page 85 of 485

Aldrich - 339741 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 06.06.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Sulfuric acid

Product Number : 339741 Brand : Aldrich Index-No. : 016-020-00-8 REACH No. : 01-2119458838-20-XXXX

CAS-No. : 7664-93-9

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Corrosive to metals (Category 1), H290 Skin corrosion (Category 1A), H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. Precautionary statement(s) P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Page 86 of 485


Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : H2O4S

Molecular weight : 98.08 g/mol CAS-No. : 7664-93-9 EC-No. : 231-639-5 Index-No. : 016-020-00-8 Registration number : 01-2119458838-20-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Sulfuric acid

CAS-No. EC-No. Index-No. Registration number

7664-93-9 231-639-5 016-020-00-8 01-2119458838-20-XXXX

Met. Corr. 1; Skin Corr. 1A; H290, H314 Concentration limits: >= 15 %: Skin Corr. 1A, H314; 5 - < 15 %: Skin Irrit. 2, H315; 5 - < 15 %: Eye Irrit. 2, H319; 0.1 - 100 %: Met. Corr. 1, H290;

<= 100 %


SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

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4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Sulphur oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, corrosive hazardous materials

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Inhalation Acute local effects 0.1 mg/m3

Workers Inhalation Long-term local effects 0.05 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Marine water 0.00025 mg/l

Fresh water 0.0025 mg/l

Marine sediment 0.002 mg/kg

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Fresh water sediment 0.002 mg/kg

Onsite sewage treatment plant 8.8 mg/l

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Fluorinated rubber Minimum layer thickness: 0.7 mm Break through time: 480 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.2 mm Break through time: 30 min Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid

b) Odour No data available

c) Odour Threshold No data available

d) pH 1.2 at 5 g/l

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e) Melting point/freezing point

3 °C

f) Initial boiling point and boiling range

290 °C - lit.

g) Flash point Not applicable

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 1.00 mmHg at 145.8 °C

l) Vapour density 3.39 - (Air = 1.0)

m) Relative density 1.84 g/cm3 at 25 °C

n) Water solubility soluble

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 55.1 mN/m at 20 °C

Relative vapour density 3.39 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Bases, Halides, Organic materials, Carbides, fulminates, Nitrates, picrates, Cyanides, Chlorates, alkali halides, Zinc salts, permanganates, e.g. potassium permanganate, Hydrogen peroxide, Azides, Perchlorates., Nitromethane, phosphorous, Reacts violently with:, cyclopentadiene, cyclopentanone oxime, nitroaryl amines, hexalithium disilicide, phosphorous(III) oxide, Powdered metals

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5

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SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 2,140 mg/kg(Sulfuric acid) LC50 Inhalation - Rat - 2 h - 510 mg/m3(Sulfuric acid)

Skin corrosion/irritation Skin - Rabbit(Sulfuric acid) Result: Extremely corrosive and destructive to tissue.

Serious eye damage/eye irritation Eyes - Rabbit(Sulfuric acid) Result: Corrosive to eyes

Respiratory or skin sensitisation No data available(Sulfuric acid)

Germ cell mutagenicity No data available(Sulfuric acid)

Carcinogenicity The International Agency for Research on Cancer (IARC) has determined that containing sulfuric acid is carcinogenic to humans (group 1).(Sulfuric acid)

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available(Sulfuric acid)

Specific target organ toxicity - single exposure No data available(Sulfuric acid)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Sulfuric acid)

Additional Information RTECS: WS5600000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Pulmonary edema. Effects may be delayed., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Sulfuric acid)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Gambusia affinis (Mosquito fish) - 42 mg/l - 96 h(Sulfuric acid) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 29 mg/l - 24 h(Sulfuric acid)

12.2 Persistence and degradability The methods for determining the biological degradability are not applicable to inorganic substances.

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12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Sulfuric acid)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1830 IMDG: 1830 IATA: 1830

14.2 UN proper shipping name ADR/RID: SULPHURIC ACID IMDG: SULPHURIC ACID IATA: Sulphuric acid

14.3 Transport hazard class(es) ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H319 Causes serious eye irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held

Page 92 of 485


liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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p. 1

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Material Safety Data SheetIsopropyl alcohol MSDS


Product Name: Isopropyl alcohol

Catalog Codes: SLI1153, SLI1579, SLI1906, SLI1246,SLI1432

CAS#: 67-63-0

RTECS: NT8050000

TSCA: TSCA 8(b) inventory: Isopropyl alcohol

CI#: Not available.

Synonym: 2-Propanol

Chemical Name: isopropanol

Chemical Formula: C3-H8-O









Composition:


Isopropyl alcohol 67-63-0 100

Toxicological Data on Ingredients: Isopropyl alcohol: ORAL (LD50): Acute: 5045 mg/kg [Rat]. 3600 mg/kg [Mouse]. 6410mg/kg [Rabbit]. DERMAL (LD50): Acute: 12800 mg/kg [Rabbit].


Potential Acute Health Effects:Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant,sensitizer, permeator).

Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.)by ACGIH, 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Notavailable. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE].The substance may be toxic to kidneys, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to thesubstance can produce target organs damage.


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p. 2


Skin Contact:Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold watermay be used.


Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.






Auto-Ignition Temperature: 399°C (750.2°F)

Flash Points: CLOSED CUP: 11.667°C (53°F) - 12.778 deg. C (55 deg. F) (TAG)

Flammable Limits: LOWER: 2% UPPER: 12.7%


Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Flammable in presence of oxidizing materials. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames andsparks, of heat.

Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.

Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. CAUTION: MAY BURN WITH NEAR INVISIBLEFLAME. Hydrogen peroxide sharply reduces the autoignition temperature of Isopropyl alcohol. After a delay, Isopropylalcohol ignites on contact with dioxgenyl tetrafluorborate, chromium trioxide, and potassium tert-butoxide. When heated todecomposition it emits acrid smoke and fumes.

Special Remarks on Explosion Hazards:Secondary alcohols are readily autooxidized in contact with oxygen or air, forming ketones and hydrogen peroxide. It canbecome potentially explosive. It reacts with oxygen to form dangerously unstable peroxides which can concentrate andexplode during distillation or evaporation. The presence of 2-butanone increases the reaction rate for peroxide formation.Explosive in the form of vapor when exposed to heat or flame. May form explosive mixtures with air. Isopropyl alcohol +phosgene forms isopropyl chloroformate and hydrogen chloride. In the presence of iron salts, thermal decompositon canoccur, whicn in some cases can become explosive. A homogeneous mixture of concentrated peroxides + isopropyl alcohol arecapable of detonation by shock or heat. Barium perchlorate + isopropyl alcohol gives the highly explosive alkyl perchlorates.

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p. 3

It forms explosive mixtures with trinitormethane and hydrogen peroxide. It produces a violent explosive reaction when heatedwith aluminum isopropoxide + crotonaldehyde. Mixtures of isopropyl alcohol + nitroform are explosive.



Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.


Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keepaway from incompatibles such as oxidizing agents, acids.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).



Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.


Exposure Limits:TWA: 983 STEL: 1230 (mg/m3) [Australia] TWA: 200 STEL: 400 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 980STEL: 1225 (mg/m3) from NIOSH TWA: 400 STEL: 500 (ppm) from NIOSH TWA: 400 STEL: 500 (ppm) [United Kingdom(UK)] TWA: 999 STEL: 1259 (mg/m3) [United Kingdom (UK)] TWA: 400 STEL: 500 (ppm) from OSHA (PEL) [United States]TWA: 980 STEL: 1225 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits.



Odor:Pleasant. Odor resembling that of a mixture of ethanol and acetone.

Taste: Bitter. (Slight.)


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p. 4

Color: Colorless.


Boiling Point: 82.5°C (180.5°F)

Melting Point: -88.5°C (-127.3°F)

Critical Temperature: 235°C (455°F)





Odor Threshold:22 ppm (Sittig, 1991) 700 ppm for unadapted panelists (Verschuren, 1983).

Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0.1


Dispersion Properties: See solubility in water, methanol, diethyl ether, n-octanol, acetone.

Solubility:Easily soluble in cold water, hot water, methanol, diethyl ether, n-octanol, acetone. Insoluble in salt solution. Soluble inbenzene. Miscible with most organic solvents including alcohol, ethyl alcohol, chloroform.




Conditions of Instability: Heat, Ignition sources, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.


Special Remarks on Reactivity:Reacts violently with hydrogen + palladium combination, nitroform, oleum, COCl2, aluminum triisopropoxide, oxidantsIncompatible with acetaldehyde, chlorine, ethylene oxide, isocyanates, acids, alkaline earth, alkali metals, caustics, amines,crotonaldehyde, phosgene, ammonia. Isopropyl alcohol reacts with metallic aluminum at high temperatures. Isopropyl alcoholattacks some plastics, rubber, and coatings. Vigorous reaction with sodium dichromate + sulfuric acid.

Special Remarks on Corrosivity: May attack some forms of plastic, rubber and coating



Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3600 mg/kg [Mouse]. Acute dermal toxicity (LD50): 12800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):16000 8 hours [Rat].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. May causedamage to the following organs: kidneys, liver, skin, central nervous system (CNS).

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p. 5

Other Toxic Effects on Humans:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:M a y c a u s e a d v e r s e r e p r o d u c t i v e / t e r a t o g e n i c e f f e c t s ( f e r t i l i t y , f e t o x i c i t y , d e v e l o p m en t a l abnormalities(developmental toxin)) based on animal studies. Detected in maternal milk in human.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause mild skin irritation, and sensitization. Eyes: Can cause eye irritation.Inhalation: Breathing in small amounts of this material during normal handling is not likely to cause harmful effects. However,breathing large amounts may be harmful and may affect the respiratory system and mucous membranes (irritation), behaviorand brain (Central nervous system depression - headache, dizziness, drowsiness, stupor, incoordination, unconciousness,coma and possible death), peripheral nerve and senstation, blood, urinary system, and liver. Ingestion: Swallowing smallamouts during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. Swallowinglarge amounts may cause gastrointestinal tract irritation with nausea, vomiting and diarrhea, abdominal pain. It also mayaffect the urinary system, cardiovascular system, sense organs, behavior or central nervous system (somnolence, generallydepressed activity, irritability, headache, dizziness, drowsiness), liver, and respiratory system (breathing difficulty). ChronicPotential Health Effects: May cause defatting of the skin and dermatitis and allergic reaction. May cause adverse reproductiveeffects based on animal data (studies).


Ecotoxicity: Ecotoxicity in water (LC50): 100000 mg/l 96 hours [Fathead Minnow]. 64000 mg/l 96 hours [Fathead Minnow].









Identification: : Isopropyl Alcohol UNNA: 1219 PG: II



Federal and State Regulations:Connecticut hazardous material survey.: Isopropyl alcohol Illinois toxic substances disclosure to employee act: Isopropylalcohol Rhode Island RTK hazardous substances: Isopropyl alcohol Pennsylvania RTK: Isopropyl alcohol Florida: Isopropylalcohol Minnesota: Isopropyl alcohol Massachusetts RTK: Isopropyl alcohol New Jersey: Isopropyl alcohol New Jersey spilllist: Isopropyl alcohol Director's list of Hazardous Substances: Isopropyl alcohol Tennesee: Isopropyl alcohol TSCA 8(b)inventory: Isopropyl alcohol TSCA 4(a) final testing order: Isopropyl alcohol TSCA 8(a) IUR: Isopropyl alcohol TSCA 8(d) H

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p. 6

and S data reporting: Isopropyl alcohol: Effective date: 12/15/86 Sunset Date: 12/15/96 TSCA 12(b) one time export: Isopropylalcohol SARA 313 toxic chemical notification and release reporting: Isopropyl alcohol



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).

DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S7- Keep container tightly closed. S16- Keep away from sources of ignition- No smoking. S24/25- Avoid contact with skin and eyes. S26- In case of contact with eyes, rinse immediately with plenty ofwater and seek medical advice.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0

Personal Protection: h


Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.




Created: 10/09/2005 05:53 PM

Last Updated: 05/21/2013 12:00 PM


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MATERIAL SAFETY DATA SHEET1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONMSDS Name: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-oneCAS Number: 91526-18-0Catalog Numbers: AX8215463For R&D use only.Company Identification: Address: 777 Dillon Dr, Wood Dale, IL 60191, USAPhone: (626)461-2812/(626)566-0337Fax: (626)228-3544

2. COMPOSITION, INFORMATION ON INGREDIENTSMolecular Formula: C5H6O4 Molecular Weight: 130.099g/mol Component Concentration4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one CAS Number 91526-18-0 -

3. HAZARDS IDENTIFICATIONEMERGENCY OVERVIEW3.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS) Skin corrosion/irritation(Category 2) H315Serious eye damage/eye irritation(Category 2A ) H319STOT- single exposure(Category 3) H335For the full text of the H-Statements metioned in this Section,see Section 16. 3.2 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Pictogram

Signal word WarningHazard statement(s) H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.Precautionary statement(s)P261 Avoid breathing dust.

P280 Wear protective gloves/protective clothing/eyeprotection/face protection.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for severalminutes. Remove contact lenses, if present andeasy to do. Continue rinsing.

Supplemental Hazard Statements None3.3 According to European Directive 67/548/EEC as amended.

www.ox-chem.comOXCHEM CORPORATION Verison 2.8

AX8215463 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Page 100 of 485

Hazard symbol(s)

R-phrase(s) R22R37/38R41

Harmful if swallowed.Irritating to respiratory system and skin.Risk of serious damage to eyes

S-phrase(s) S26 In case of contact with eyes, rinse

immediately with plenty of water and seek medicaladvice.

S36/39Wear suitable protective clothing and eye/faceprotection

3.4 Other hazards None

4. FIRST AID MEASURESEyes: Flush eyes with plenty of water occasionally lifting the upper and lower lids. Get medical aid.Skin: Get medical aid. Flush skin with plenty of water while removing contaminated clothing and shoes.Ingestion: Get medical aid. Wash mouth out with water.Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificialrespiration. If breathing is difficult, give oxygen.

5. FIRE FIGHTING MEASURESGeneral Information: As in any fire, wear a self-contained breathing apparatus and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide or chemical foam.

6. ACCIDENTAL RELEASE MEASURESGeneral Information: Use proper personal protective equipment.Spills/Leaks: Vacuum or sweep up material and place into suitable disposalcontainer. Avoid generating dustyconditions.

7. HANDLING AND STORAGEHandling: Avoid breathing dust, vapor, mist or gas. Avoid contact with eyes, skin.Storage: Storage: Keep container tightly closed. Store in a cool, dark and well-ventilated place.Store away from incompatible materials such as oxidizing agents.

Recommended storage temperature: 2 - 4 °C

8. EXPOSURE CONTROLS, PERSONAL PROTECTIONEngineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facilityand safety shower. Use adequate ventilation to keep airborne concentrations low. Personal Protective EquipmentEyes: Wear chemical safety goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Wear appropriate respirators where necessary.




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Appearance N/A Boiling Point No data available. Melting Point No data available. Flash point No data available. Water solubility Slightly soluble. Ignition temperature No data available. Lower explosion limit No data available. Upper explosion limit No data available.

10. STABILITY AND REACTIVITYChemical Stability: This product is relatively unstable under normal temperature. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous combustion or Decomposition products: Carbon monoxide, and carbon dioxide.

11. TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityNo data available.Skin corrosion/irritationNo data available.Serious eye damage/eye irritationNo data available.Respiratory or skin sensitizationNo data available.Germ cell mutagenicityNo data available.CarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.Reproductive toxicityNo data available.Specific target organ toxicity - single exposureNo data available.Specific target organ toxicity - repeated exposureNo data available.Aspiration hazardNo data available.Additional InformationRTECS: No data available.Burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, To thebest of our knowledge, the chemical, physical, and toxicological properties have not been thoroughlyinvestigate.

12. ECOLOGICAL INFORMATION12.1 ToxicityNo data available. 12.2 Persistence and degradabilityNo data available. 12.3 Bioaccumulative potentialNo data available. 12.4 Mobility in soilNo data available. 12.5 Results of PBT and vPvB assessmentNo data available.



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12.6 Other adverse effectsNo data available.

13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professionalwaste disposal service to dispose of this material. Dissolve or mix the material with a combustible solventand burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packagingDispose of as unused product.

14. TRANSPORT INFORMATION14.1 DOT (US)Not dangerous goods14.2 UN numberADR/RID: _ IMDG: _ IATA: _14.3 UN proper shipping nameADR/RID:IMDG:IATA:

Not dangerous goodsNot dangerous goodsNot dangerous goods

14.4 Transport hazard class(es)ADR/RID: _ IMDG: _ IATA: _14.5 Packaging groupADR/RID: _ IMDG: _ IATA: _14.6 Environmental hazardsADR/RID: No IMDG Marine pollutant: No IATA: No14.7 Special precautions for userNo data available.

15. REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.Safety, health and environmental regulations/legislation specific for the substance or mixture:No data available.Chemical Safety Assessment: No data available. 16. ADDITIONAL INFORMATION Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May Cause respiratory irritation.

HMIS RatingHealth hazard: 0Chronic Health Hazard: 0Flammability: 0Physical Hazard: 0

FPA RatingHealth hazard: 0FIRE Hazard: 0Reactivity Hazard: 0

Further information Copyright 2013 OXCHEM CORPORATION License granted to make unlimited paper



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copies for internal use only.The above information pertains to this product as currently formulated, and is based onthe information available at this time. Addition of reducers or other additives to thisproduct may substantially alter the composition and hazards of the product. Sinceconditions of use are outside our control, we make no warranties, express or implied,and assume no liability in connection with any use of this information.



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Manufacturer: Strem Chemicals, Inc7 Mulliken WayNewburyport, MA 01950-4098 U.S.A.www.strem.com

Strem Customer ServiceCHEMTREC (Emergency Only)Poison Center

(978) 499-1600(800) 424-9300(800) 562-8236

Section 1: Product IdentificationChemical Name: Potassium 2-ethylhexanoate hydrate, 95%Product Number: 19-1920CAS Registry Number: 3164-85-0Formula: K[OOCCH(C2H5)C4H9].XH2OEINECS Number: noneChemical Family: metal carboxylateSynonym: potassium-2-ethylcaproate, 2-ethylcaproic acid, potassium salt.

Section 2: Composition and Information on IngredientsIngredient CAS Number Percent ACGIH (TWA) OSHA (PEL)Title Compound 3164-85-0 100% no data no data

Section 3: Hazards IdentificationEmergency Overview: Irritating to skin, eyes and respiratory tract.Primary Routes of Exposure: Ingestion, inhalationEye Contact: Causes slight to mild irritation of the eyes.Skin Contact: Causes slight to mild irritation of the skin.Inhalation: Irritating to the nose, mucous membranes and respiratory tract.Ingestion: No information on the physiological effects of ingestion.Acute Health Affects: Irritating to skin, eyes and respiratory tract.Chronic Health Affects: No information available on long-term chronic effects.NTP: NoIARC: NoOSHA: No

SECTION 4: First Aid Measures

Eye Exposure:Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may needassistance in keeping their eye lids open. Get immediate medical attention.

Skin Exposure:Wash the affected area with soap and water. Remove contaminated clothes if necessary. Seek medicalassistance if irritation persists.

Inhalation:Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficultyin breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.

Ingestion: Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious).

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(978) 499-1600(800) 424-9300(800) 562-8236

SECTION 5: Fire Fighting MeasuresFlash Point: not applicableAutoignition Temperature: noneExplosion Limits: noneExtinguishing Medium: carbon dioxide, dry powder or foam

Special Fire Fighting Procedures:If involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure self-containedbreathing apparatus and full protective clothing.

Hazardous Combustion andDecomposion Products:

If involved in a fire this material may emit toxic organic fumes.

Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

SECTION 6: Accidental Release MeasuresSpill and Leak Procedures: Small spills can be mixed with vermiculite or sodium carbonate and swept up.

SECTION 7: Handling and StorageHandling and Storage: Store in a sealed container. Keep away from heat and moisture.

SECTION 8: Exposure Controls and Personal ProtectionEye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.Skin Protection: Wear appropriate chemical resistant gloves and protective clothing.Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.

Respirator:If in form of fine dust and ventilation is not available a respirator should be worn. The use of respiratorsrequires a Respirator Protection Program to be in compliance with 29 CFR 1910.134.

Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.Additional Protection: No additional protection required.

SECTION 9: Physical and Chemical PropertiesColor and Form: slightly yellow, glassy solidMolecular Weight: 182.3Melting Point: no dataBoiling Point: no dataVapor Pressure: no dataSpecific Gravity: no dataOdor: noneSolubility in Water: soluble

SECTION 10:Stability and ReactivityStability: air and moisture stable solidHazardous Polymerization: no hazardous polymerizationConditions to Avoid: noneIncompatibility: oxidizing agents and active metalsDecomposition Products: Carbon dioxide, carbon monoxide, organic vapors, and metal oxides and carbonates.

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(978) 499-1600(800) 424-9300(800) 562-8236

SECTION 11:Toxicological InformationRTECS Data: No information available in the RTECS files.Carcinogenic Effects: No data availableMutagenic Effects: No data availableTetratogenic Effects: No data available

SECTION 12:Ecological InformationEcological Information: No information available

SECTION 13:Disposal ConsiderationsDisposal: Dispose of according to local, state and federal regulations.

SECTION 14:TransportationShipping Name (CFR): Non-hazardousHazard Class (CFR): NAAdditional Hazard Class (CFR): NAPackaging Group (CFR): NAUN ID Number (CFR): NAShipping Name (IATA): Non-hazardousHazard Class (IATA): NAAdditional Hazard Class (IATA): NAPackaging Group (IATA): NAUN ID Number (IATA): NA

SECTION 15:Regulatory InformationTSCA: Listed in the TSCA inventory.SARA (Title 313): Title compound not listed.Second Ingredient: noneThird Ingredient: none

SECTION 16:Other Information

Disclaimer:The information herein is believed to be accurate and reliable as of the date compiled. However, StremChemicals, Inc. makes no representation, warranty, or guarantee of any kind with respect to the informationcontained in this document or any use of the product based on this information.

Preparation Date: 12/28/2000Revision Date: 12/13/2011

Strem Chemicals, Inc.7 Mulliken WayNewburyport, MA 01950-4098 USATel: (978) 499 1600Fax: (978) 465 3104Toll free (in USA & Canada)Tel: (800) 647 8736Fax: (800) 517 [email protected]

Strem Chemicals, Inc.15, rue de l'Atome, Z.I.67800 BISCHHEIM (France)Tel: (33) 03 88 62 52 60Fax: (33) 03 88 62 26 [email protected]

Strem Chemicals, Inc.Postfach 121577672 KEHL (Germany)Telefon: 0 78 51/ 7 58 [email protected]

Strem Chemicals UK, Ltd.41 Hills RoadCambridge, England CB2 1NTTel: 0845 643 7263Fax: 0845 643 [email protected]

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Material Safety Data SheetHydroxylamine hydrochloride MSDS


Product Name: Hydroxylamine hydrochloride

Catalog Codes: SLH1981

CAS#: 5470-11-1

RTECS: NC3675000

TSCA: TSCA 8(b) inventory: Hydroxylamine hydrochloride

CI#: Not available.

Synonym: Hydroxyamine hydrochloride;Hydroxammonium chloride; Hydroxylamine chloride;Hydroxylammonium chloride; Oxammonium chloride

Chemical Name: Hydroxylamine Hydrochloride

Chemical Formula: NH2OH.HCl









Composition:


Hydroxylamine hydrochloride 5470-11-1 100

Toxicological Data on Ingredients: Hydroxylamine hydrochloride: ORAL (LD50): Acute: 408 mg/kg [Mouse]. 141 mg/kg[Rat].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in caseof skin contact (corrosive, sensitizer), of eye contact (corrosive). The amount of tissue damage depends on length of contact.Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation ofdust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severeover-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized byredness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.

Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, cardiovascular system, upper respiratory

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tract, skin, eyes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposureof the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction,or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage. Repeatedexposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many humanorgans.


Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention immediately.

Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.



Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.

Ingestion:If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately.



Flammability of the Product: May be combustible at high temperature.


Flash Points: CLOSED CUP: 152°C (305.6°F).


Products of Combustion: Not available.

Fire Hazards in Presence of Various Substances:Slightly flammable to flammable in presence of heat. Non-flammable in presence of open flames and sparks, of shocks.

Explosion Hazards in Presence of Various Substances:Slightly explosive in presence of open flames and sparks, of heat. Non-explosive in presence of shocks.

Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards:Decompostion may be initiated by action of localized heat. Nitrogen oxides, Hydrogen chloride, ammonia and/or derivativesare hazardous decomposition products. Decomposition starts at temperatures above 115 C. Decomposes violently orexplosively when heated above 140 °C.

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Special Remarks on Explosion Hazards:Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosionhazard. Decomposes violently or explosively when heated above 140 °C.


Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:Corrosive solid. Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Usewater spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignitionsources. Call for assistance on disposal.


Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporatethe residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Never addwater to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical adviceimmediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such asoxidizing agents, combustible materials, organic materials, alkalis.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Hygroscopic Moisture sensitive.



Personal Protection:Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained breathing apparatus should be used toavoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handlingthis product.



Physical state and appearance: Solid. (Crystalline solid.)

Odor: Odorless.



Color: White to yellowish.

pH (1% soln/water): 3.2 [Acidic.]


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Melting Point: Decomposition temperature: 151°C (303.8°F) -157 C










Solubility:Easily soluble in hot water. Soluble in cold water. Solubility in water: 560 g/l @ 20 deg. C; 83 g/100 mg @ 17 deg. C.




Conditions of Instability: Excess heat, incompatible materials, moisture

Incompatibility with various substances: Reactive with oxidizing agents, combustible materials, organic materials, alkalis.


Special Remarks on Reactivity:Moisture sensitive Hygroscopic; keep container tightly closed. Also incompatible with heat + sodium acetate or ether, carbonylcompounds, copper sulfate, zinc and phosphorus chlorides, aldehydes, ketones, iron and its salts, heavy metals salts,combustible and flammable materials (e.g. alkyl resins, asphalt, gasoline, grease, methyl acetone, polystyrene, polyurethane).Hydroxylamine Hydrochloride reacts with alkalis to give free Hydroxylamine, which decomposes, especially in the presence ofheavy metal ions and at elevated temperatures.






Chronic Effects on Humans: MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.

Other Toxic Effects on Humans:Very hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact(corrosive, sensitizer), of eye contact (corrosive).


Special Remarks on Chronic Effects on Humans: May affect genetic material (mutagenic)

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Depending on the duration of skin contact, it may cause reddening, discomfort, severeirritation, and possible chemical burns. Chemical burns result in blistering of the skin and possible scarring. Skin contact may

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cause allergic sensitization and reaction in susceptible individuals. Eyes: Contact with eyes will cause severe irritation, pain,reddening, watering, and possibly burns, corneal damage and blindness. Inhalation: It may be destructive to the tissues of themucous membranes and upper respiratory tract. Symtoms may include respiratory tract irritation or burning sensation/burnsof the mucous membranes, breathing difficulty, coughing, wheezing, shortness of breath, dyspnea (labored breathing), nasalcongestion, laryngitis, sore throat, headache, nausea, vomiting, and Methemoglobinemia (a condition that affects the abilityof the blood to carry oxygen), and cyanosis (blue color of the skin due to lack of oxygen). Inhalation of low levels can causeallergic sensitization and reaction in susceptible individuals. Severe inhalation over-exposure can be fatal as a result of spasm,inflammation, edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure maybe delayed. Ingestion: Harmful if swallowed. It can cause severe irritation and burns of the mouth, throat, esophagus, andother tissues of the digestive tract, nausea, vomiting, diarrhea. Conversion of hemoglobin to methemoglobin may also occurproducing cyanosis (see acute inhalation). It may also cause a fall in blood pressure, ringing in the ears, shortness of breath,and affect behavior/central nervous system (headache, vertigo, convulsions). Ingestion of large volumes may cause coma andbe fatal as a result of circulatory collapse. Chronic Potential Health Effects: Skin: Repeated or prolonged skin contact to lowconcentrations may cause dermatitis. Inhalation: Repeated or prolonged inhalation may cause allergic reaction in sensitizedindividuals. Inhalation/Ingestion: Prolonged or repeated exposure by inhalation or ingestion may affect metabolism (decreasedappetite, weight loss), spleen, thyroid and blood/cause bone marrow damage(decreased leukocyte count, anemia). It may alsocause liver, kidney, and bone marrow damage. This substance is a blood toxin. Prolonged










DOT Classification:Class 8: Corrosive material CLASS 6.1: Poisonous material.

Identification: : Corrosive Solid, toxic, n.o.s. (Hydroxylamine Hydrochloride) UNNA: 2923 PG: III



Federal and State Regulations:TSCA 8(b) inventory: Hydroxylamine hydrochloride TSCA 8(a) CAIR: Hydroxylamine hydrochloride



WHMIS (Canada):

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CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects(TOXIC). CLASS E: Corrosive solid.

DSCL (EEC):R22- Harmful if swallowed. Although the EU has classified it as R22, toxicity data shows that it should be classifed as R25- Toxic if Swallowed. R36/38- Irritating to eyes and skin. R43- May cause sensitization by skin contact. R50- Very toxic toaquatic organisms. R48/22- Harmful: danger of serious S22- Do not breathe dust. S24- Avoid contact with skin. S36/37/39-Wear suitable protective clothing, gloves and eye/face protection. S61- Avoid release to the environment. Refer to specialinstructions/Safety data sheets.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 1

Reactivity: 0



Health: 3

Flammability: 1

Reactivity: 1

Specific hazard:

Protective Equipment:Gloves. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Wearappropriate respirator when ventilation is inadequate. Splash goggles.




Created: 10/10/2005 08:20 PM

Last Updated: 05/21/2013 12:00 PM


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1.1 Product identifiers Product name : Ethyl chloroformate

Product Number : 185892 Brand : Aldrich Index-No. : 607-020-00-4 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 541-41-3









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Inhalation (Category 1), H330 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 3), H301 Skin corrosion (Category 1B), H314 Acute aquatic toxicity (Category 1), H400


2.2 Label elements


Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H301 Toxic if swallowed.

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H314 Causes severe skin burns and eye damage. H330 Fatal if inhaled. H400 Very toxic to aquatic life. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P284 Wear respiratory protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Supplemental Hazard Statements

none



3.1 Substances Formula : C3H5ClO2C3H5ClO2

Molecular weight : 108.52 g/mol CAS-No. : 541-41-3 EC-No. : 208-778-5 Index-No. : 607-020-00-4 Hazardous ingredients according to Regulation (EC) No 1272/2008


Ethyl chloroformate

CAS-No. EC-No. Index-No.

541-41-3 208-778-5 607-020-00-4

Acute Tox. 1; Flam. Liq. 2; Acute Tox. 3; Skin Corr. 1B; Aquatic Acute 1; H330, H225, H301, H314, H400

<= 100 %






In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.




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5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas


5.4 Further information Use water spray to cool unopened containers.


6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).



7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Moisture sensitive. Store under inert gas. Storage class (TRGS 510): Flammable liquids





Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.


Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.



a) Appearance Form: liquid, clear Colour: colourless



d) pH < 7


Melting point/range: -81 °C - lit.


93 °C - lit.

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g) Flash point 10 °C - closed cup - DIN 51755 Part 1




Upper explosion limit: 12.6 %(V) at 125.5 hPa Lower explosion limit: 3.7 %(V) at 37 hPa

k) Vapour pressure 54 mbar at 20 °C 217 hPa at 50 °C



n) Water solubility insoluble


log Pow: -0.299 at 20 °C


No data available


No data available





Surface tension 27.5 mN/m at 15 °C






10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Alcohols, Activated carbon, Keep away from water., Amines, Iron and iron salts., Metals

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

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Acute toxicity LD50 Oral - Rat - 270 mg/kg(Ethyl chloroformate) LC50 Inhalation - Rat - 1 h - 0.64 mg/l(Ethyl chloroformate) LD50 Dermal - Rabbit - 7,120 mg/kg(Ethyl chloroformate)

Skin corrosion/irritation Skin - Rabbit(Ethyl chloroformate) Result: Corrosive

Serious eye damage/eye irritation No data available(Ethyl chloroformate)

Respiratory or skin sensitisation No data available(Ethyl chloroformate)

Germ cell mutagenicity No data available(Ethyl chloroformate)

Carcinogenicity


Reproductive toxicity No data available(Ethyl chloroformate)

Specific target organ toxicity - single exposure No data available(Ethyl chloroformate)


Aspiration hazard No data available(Ethyl chloroformate)

Additional Information RTECS: Not available burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin.(Ethyl chloroformate) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Ethyl chloroformate) Liver - Irregularities - Based on Human Evidence(Ethyl chloroformate)


12.1 Toxicity Toxicity to fish LC50 - Cyprinus carpio (Carp) - 4.92 mg/l - 96 h(Ethyl chloroformate)

(OECD Test Guideline 203) Toxicity to daphnia and other aquatic invertebrates

static test ECx - Daphnia magna (Water flea) - 56 mg/l - 72 h(Ethyl chloroformate)

Toxicity to algae static test EC50 - SELENASTRUM - 0.492 mg/l - 96 h(Ethyl chloroformate)

(OECD Test Guideline 201)

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12.2 Persistence and degradability Biodegradability Result: - Readily biodegradable Biochemical Oxygen Demand (BOD)

< 10 mg/g(Ethyl chloroformate)

Chemical Oxygen Demand (COD)

1,000 mg/g(Ethyl chloroformate)


12.4 Mobility in soil No data available(Ethyl chloroformate)


12.6 Other adverse effects Very toxic to aquatic life. Additional ecological information

No data available



Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.




14.2 UN proper shipping name ADR/RID: ETHYL CHLOROFORMATE IMDG: ETHYL CHLOROFORMATE IATA: Ethyl chloroformate Passenger Aircraft: Not permitted for transport Cargo Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 6.1 (3, 8) IMDG: 6.1 (3, 8) IATA: 6.1 (3, 8)

14.4 Packaging group ADR/RID: I IMDG: I IATA: -





15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

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H225 Highly flammable liquid and vapour. H301 Toxic if swallowed. H314 Causes severe skin burns and eye damage. H330 Fatal if inhaled. H400 Very toxic to aquatic life.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Material Safety Data SheetTriethylamine MSDS


Product Name: Triethylamine


CAS#: 121-44-8

RTECS: YE0175000

TSCA: TSCA 8(b) inventory: Triethylamine

CI#: Not applicable.

Synonym: Diethylamino ethane

Chemical Name: Ethanamine, N,N-diethyl

Chemical Formula: (CH3CH2)3N









Composition:


Triethylamine 121-44-8 100

Toxicological Data on Ingredients: Triethylamine: ORAL (LD50): Acute: 460 mg/kg [Rat.]. DERMAL (LD50): Acute: 570 mg/kg [Rabbit.].


Potential Acute Health Effects:Very hazardous in case of eye contact (irritant). Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous incase of ingestion. Inflammation of the eye is characterized by redness, watering, and itching.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to kidneys, liver. Repeated or prolonged exposure to thesubstance can produce target organs damage.


Eye Contact:

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Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Finish by rinsing thoroughly with running water to avoid a possible infection. Cold water may be used.

Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing beforereusing.


Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.


Ingestion:Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication thatthe toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar,tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.




Auto-Ignition Temperature: 215°C (419°F)

Flash Points: CLOSED CUP: -8.3°C (17.1°F). OPEN CUP: -6.67°C (20°F) (Cleveland).

Flammable Limits: LOWER: 1.2% UPPER: 8%


Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat, ofoxidizing materials.



Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. When heated to decomposition it emits toxicfumes.



Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of acetic acid. Finish cleaning by spreading water on the contaminatedsurface and dispose of according to local and regional authority requirements.

Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined

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areas; dike if needed. Eliminate all ignition sources. Neutralize the residue with a dilute solution of acetic acid. Be careful thatthe product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapour/spray. In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seekmedical advice immediately and show the container or the label. Avoid contact with skin and eyes

Storage:Alkalis may be stored in heavy duty gauge steel containers. Flammable materials should be stored in a separate safetystorage cabinet or room. Keep away from heat. Keep away from sources of ignition. Keep container tightly closed. Keep in acool, well-ventilated place. Ground all equipment containing material. A refrigerated room would be preferable for materialswith a flash point lower than 37.8°C (100°F).





Exposure Limits:TWA: 10 STEL: 15 (ppm) from ACGIH (TLV) [1995] TWA: 41 STEL: 62 (mg/m3) from ACGIH [1995] Consult local authoritiesfor acceptable exposure limits.


Physical state and appearance: Liquid. (Oily liquid.)

Odor: Ammoniacal. (Strong.)



Color: Colorless.

pH (1% soln/water): 10 [Basic.]


Melting Point: -115°C (-175°F)



Vapor Pressure: 54 mm of Hg (@ 20°C)



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Dispersion Properties: See solubility in water, methanol, diethyl ether.

Solubility: Easily soluble in cold water, hot water, methanol, diethyl ether.




Conditions of Instability: Not available.

Incompatibility with various substances: Slightly reactive to reactive with oxidizing agents.


Special Remarks on Reactivity: Not available.


Polymerization: No.


Routes of Entry: Eye contact. Inhalation.

Toxicity to Animals:Acute oral toxicity (LD50): 460 mg/kg [Rat.]. Acute dermal toxicity (LD50): 570 mg/kg [Rabbit.].

Chronic Effects on Humans: The substance is toxic to kidneys, liver.

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of ingestion.


Special Remarks on Chronic Effects on Humans: Lacrymator.

Special Remarks on other Toxic Effects on Humans: Material is destructive to tissue of the mucous membranes and upperrespiratory tract.





Toxicity of the Products of Biodegradation: The products of degradation are more toxic.



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Waste Disposal:


DOT Classification: Class 3: Flammable liquid.

Identification: : Triethylamine : UN1296 PG: II



Federal and State Regulations:Massachusetts RTK: Triethylamine TSCA 8(b) inventory: Triethylamine SARA 313 toxic chemical notification and releasereporting: Triethylamine CERCLA: Hazardous substances.: Triethylamine

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).


WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-1B: Material causing immediate andserious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects (TOXIC).

DSCL (EEC):R11- Highly flammable. R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 3

Reactivity: 0



Health: 3

Flammability: 3

Reactivity: 0

Specific hazard:



References:-Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -Material safetydata sheet emitted by: la Commission de la Santé et de la Sécurité du Travail du Québec. -SAX, N.I. Dangerous Propertiesof Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -The Sigma-Aldrich Library of Chemical Safety Data,Edition II. -Guide de la loi et du règlement sur le transport des marchandises dangeureuses au canada. Centre de conformitéinternatinal Ltée. 1986.


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Created: 10/10/2005 12:08 AM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetSodium hydroxide MSDS


Product Name: Sodium hydroxide


CAS#: 1310-73-2

RTECS: WB4900000

TSCA: TSCA 8(b) inventory: Sodium hydroxide

CI#: Not available.

Synonym: Caustic Soda

Chemical Name: Sodium Hydroxide

Chemical Formula: NaOH









Composition:


Sodium hydroxide 1310-73-2 100

Toxicological Data on Ingredients: Sodium hydroxide LD50: Not available. LC50: Not available.


Potential Acute Health Effects:Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (irritant, corrosive), of ingestion,of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage orblindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal orrespiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking,unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation ischaracterized by itching, scaling, reddening, or, occasionally, blistering.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic tomucous membranes, upper respiratory tract, skin, eyes. Repeated or prolonged exposure to the substance can produce targetorgans damage. Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure canproduce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation orlung damage.

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Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.


Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.








Fire Hazards in Presence of Various Substances: metals

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive in presence of heat.

Fire Fighting Media and Instructions: Not available

Special Remarks on Fire Hazards:sodium hydroxide + zinc metal dust causes ignition of the latter. Under proper conditions of temperature, pressure and stateof division, it can ignite or react violently with acetaldehyde, ally alcohol, allyl chloride, benzene-1,4-diol, chlorine trifluoride,1,2 dichlorethylene, nitroethane, nitromethane, nitroparaffins, nitropropane, cinnamaldehyde, 2,2-dichloro-3,3-dimethylbutane.Sodium hydroxide in contact with water may generate enough heat to ignite adjacent combustible materials. Phosphorousboiled with NaOH yields mixed phosphines which may ignite spontanously in air. sodium hydroxide and cinnamaldehyde +heat may cause ignition. Reaction with certain metals releases flammable and explosive hydrogen gas.

Special Remarks on Explosion Hazards:Sodium hydroxide reacts to form explosive products with ammonia + silver nitrate. Benzene extract of allyl benzenesulfonateprepared from allyl alcohol, and benzene sulfonyl chloride in presence of aquesous sodium hydroxide, under vacuumdistillation, residue darkened and exploded. Sodium Hydroxde + impure tetrahydrofuran, which can contain peroxides, can

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cause serious explosions. Dry mixtures of sodium hydroxide and sodium tetrahydroborate liberate hydrogen explosively at230-270 deg. C. Sodium Hydroxide reacts with sodium salt of trichlorophenol + methyl alcohol + trichlorobenzene + heat tocause an explosion.


Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue witha dilute solution of acetic acid.

Large Spill:Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water sprayto reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal.Neutralize the residue with a dilute solution of acetic acid. Be careful that the product is not present at a concentration levelabove TLV. Check TLV on the MSDS and with local authorities.


Precautions:Keep container dry. Do not breathe dust. Never add water to this product. In case of insufficient ventilation, wear suitablerespiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skinand eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis, moisture.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Hygroscopic. Deliquescent.





Exposure Limits:STEL: 2 (mg/m3) from ACGIH (TLV) [United States] TWA: 2 CEIL: 2 (mg/m3) from OSHA (PEL) [United States] CEIL: 2 (mg/m3) from NIOSHConsult local authorities for acceptable exposure limits.


Physical state and appearance: Solid. (Deliquescent solid.)

Odor: Odorless.


Molecular Weight: 40 g/mole

Color: White.

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pH (1% soln/water): 13.5 [Basic.]












Solubility: Easily soluble in cold water.




Conditions of Instability: Incompatible materials, moisture, moist air

Incompatibility with various substances:Highly reactive with metals. Reactive with oxidizing agents, reducing agents, acids, alkalis, moisture.


Special Remarks on Reactivity:Hygroscopic. Much heat is evolved when solid material is dissolved in water. Therefore cold water and caution must be usedfor this process. Sodium hydroxide solution and octanol + diborane during a work-up of a reaction mixture of oxime anddiborane in tetrahyrofuran is very exothermic, a mild explosion being noted on one occassion. Reactive with water, acids(mineral, non-oxidizing, e.g. hydrochloric, hydrofluoric acid, muriatic acid, phosphoric), acids (mineral, oxidizing e.g. chromicacid, hypochlorous acid, nitric acid, sulfuric acid), acids (organic e.g. acetic acid, benzoic acid, formic acid, methanoic acid,oxalic acid), aldehydes (e.g. acetaldehyde, acrolein, chloral hydrate, foraldehyde), carbamates (e.g. carbanolate, carbofuran),esters (e.g. butyl acetate, ethyl acetate, propyl formate), halogenated organics (dibromoethane, hexachlorobenzene, methylchloride, trichloroethylene), isocyanates (e.g. methyl isocyanate), ketones (acetone, acetophenone, MEK, MIBK), acidchlorides, strong bases, strong oxidizing agents, strong reducing agents, flammable liquids, powdered metals and metals (i.ealuminum, tin, zinc, hafnium, raney nickel), metals (alkali and alkaline e.g. cesium, potassium, sodium), metal compounds(toxic e.g. berylium, lead acetate, nickel carbonyl, tetraethyl lead), mitrides (e.g. potassium nitride, sodium nitride), nitriles(e.g. acetonitrile, methyl cyanide), nitro compounds (organic e.g. nitrobenzene, nitromethane), acetic anhydride, chlorohydrin,chlorosulfonic acid, ethylene cyanohydrin, glyoxal, hydrosulfuric acid, oleum, propiolactone, acylonitrile, phorosous pentoxide,chloroethanol, chloroform-methanol, tetrahydroborate, cyanogen azide, 1,2,4,5 tetrachlorobenzene, cinnamaldehyde. Reactswith formaldehyde hydroxide to yield formic acid, and hydrogen.

Special Remarks on Corrosivity: Very caustic to aluminum and other metals in presence of moisture.



Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.

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Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. May cause damage to the following organs: mucousmembranes, upper respiratory tract, skin, eyes.

Other Toxic Effects on Humans:Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (corrosive, irritant,permeator), of eye contact (corrosive), of ingestion, .

Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LDL [Rabbit] - Route: Oral; Dose: 500 mg/kg

Special Remarks on Chronic Effects on Humans: May affect genetic material. Investigation as a mutagen (cytogeneticanalysis)

Special Remarks on other Toxic Effects on Humans:










DOT Classification: Class 8: Corrosive material

Identification: : Sodium hydroxide, solid UNNA: 1823 PG: II



Federal and State Regulations:Illinois toxic substances disclosure to employee act: Sodium hydroxide Illinois chemical safety act: Sodium hydroxide NewYork release reporting list: Sodium hydroxide Rhode Island RTK hazardous substances: Sodium hydroxide PennsylvaniaRTK: Sodium hydroxide Minnesota: Sodium hydroxide Massachusetts RTK: Sodium hydroxide New Jersey: Sodium hydroxideLouisiana spill reporting: Sodium hydroxide California Director's List of Hazardous Substances: Sodium hydroxide TSCA 8(b)inventory: Sodium hydroxide CERCLA: Hazardous substances.: Sodium hydroxide: 1000 lbs. (453.6 kg)


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WHMIS (Canada): CLASS E: Corrosive solid.

DSCL (EEC):R35- Causes severe burns. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.S37/39- Wear suitable gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical adviceimmediately (show the label where possible).

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 0

Reactivity: 2



Health: 3

Flammability: 0

Reactivity: 1

Specific hazard:





Created: 10/09/2005 06:32 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data Sheetp-Toluenesulfonyl chloride MSDS


Product Name: p-Toluenesulfonyl chloride


CAS#: 98-59-9

RTECS: Not available.

TSCA: TSCA 8(b) inventory: p-Toluenesulfonyl chloride

CI#: Not available.

Synonym:

Chemical Name: Not available.

Chemical Formula: CH3C6H4SO2Cl









Composition:


{p-}Toluenesulfonyl chloride 98-59-9 100

Toxicological Data on Ingredients: p-Toluenesulfonyl chloride LD50: Not available. LC50: Not available.


Potential Acute Health Effects:Extremely hazardous in case of skin contact (irritant), of eye contact (irritant). Very hazardous in case of ingestion, ofinhalation. Hazardous in case of skin contact (corrosive, permeator). The amount of tissue damage depends on lengthof contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering.Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing andcoughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eyeis characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated exposure of the eyes to a low level of dust can produce eye irritation.Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varyingdegree of respiratory irritation or lung damage.

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Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.

Skin Contact:If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible, protectingyour own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's exposed skin, suchas the hands : Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularlycareful to clean folds, crevices, creases and groin. If irritation persists, seek medical attention. Wash contaminated clothingbefore reusing.




Ingestion:Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, performmouth-to-mouth resuscitation. Seek immediate medical attention.





Flash Points: Not available.


Products of Combustion: These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).

Fire Hazards in Presence of Various Substances: Not available.







Large Spill:Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray toreduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call forassistance on disposal.

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Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporatethe residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Never add water to thisproduct In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention andshow the label when possible. Avoid contact with skin and eyes Keep away from incompatibles such as moisture.

Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Corrosive materials should be stored in aseparate safety storage cabinet or room.







Physical state and appearance: Solid.

Odor: Not available.



Color: Not available.


Boiling Point: Decomposes.



Specific Gravity: Not available.







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Dispersion Properties: Not available.

Solubility: Not available.





Incompatibility with various substances: Reactive with moisture.




Polymerization: No.


Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.



Other Toxic Effects on Humans:Extremely hazardous in case of skin contact (irritant). Very hazardous in case of ingestion, of inhalation. Hazardous in case ofskin contact (corrosive, permeator).



Special Remarks on other Toxic Effects on Humans: Not available.








Waste Disposal:


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DOT Classification: CLASS 8: Corrosive solid.

Identification: : Corrosive solid, n.o.s. (Toluenesulfonyl chloride) : UN1759 PG: III



Federal and State Regulations:Minnesota: p-Toluenesulfonyl chloride TSCA 8(b) inventory: p-Toluenesulfonyl chloride




DSCL (EEC):R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 1

Reactivity: 2



Health: 3

Flammability: 1

Reactivity: 2

Specific hazard:





Created: 10/10/2005 12:06 AM

Last Updated: 05/21/2013 12:00 PM


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1.1 Product identifiers Product name : 4-(Dimethylamino)pyridine

Product Number : 522805 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 1122-58-3









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Dermal (Category 2), H310 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335


2.2 Label elements


Signal word Danger Hazard statement(s) H301 Toxic if swallowed. H310 Fatal in contact with skin. H315 Causes skin irritation.

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H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse

mouth. P302 + P352 + P310 IF ON SKIN: Wash with plenty of water. Immediately call a POISON

CENTER/doctor. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P337 + P313 If eye irritation persists: Get medical advice/ attention. Supplemental Hazard Statements

none



3.1 Substances Synonyms : DMAP

Formula : C7H10N2

Molecular weight : 122.17 g/mol CAS-No. : 1122-58-3 EC-No. : 214-353-5 Hazardous ingredients according to Regulation (EC) No 1272/2008


N,N-Dimethylpyridin-4-amine

CAS-No. EC-No.

1122-58-3 214-353-5

Acute Tox. 3; Acute Tox. 2; Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; H301, H310, H315, H319, H335

<= 100 %






In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.


If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)




6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.



7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials






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Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.



a) Appearance Form: crystalline Colour: beige



d) pH 11.14 at 5 °C


Melting point/range: 108 - 110 °C


162 °C at 67 hPa

g) Flash point 110 °C - closed cup

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No data available

k) Vapour pressure 0.169 hPa at 25 °C

l) Vapour density No data available

m) Relative density No data available

n) Water solubility 76 g/l at 20 °C


log Pow: 1.34


420 °C


No data available





Dissociation constant 10.14 at 5 °C






10.5 Incompatible materials acids, Oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 140 mg/kg(N,N-Dimethylpyridin-4-amine) LD50 Dermal - Rabbit - 90 mg/kg(N,N-Dimethylpyridin-4-amine) LD50 Dermal - Guinea pig - 100 - 200 mg/kg(N,N-Dimethylpyridin-4-amine)

Skin corrosion/irritation Irritating to skin.(N,N-Dimethylpyridin-4-amine)

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Serious eye damage/eye irritation Irritating to eyes.(N,N-Dimethylpyridin-4-amine)

Respiratory or skin sensitisation Buehler Test(N,N-Dimethylpyridin-4-amine) Result: Does not cause skin sensitisation.

Germ cell mutagenicity No data available(N,N-Dimethylpyridin-4-amine)

Carcinogenicity


Reproductive toxicity No data available(N,N-Dimethylpyridin-4-amine)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(N,N-Dimethylpyridin-4-amine)


Aspiration hazard No data available(N,N-Dimethylpyridin-4-amine)

Additional Information RTECS: US9230000 Weakness, Convulsions(N,N-Dimethylpyridin-4-amine)


12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No bioaccumulation is to be expected (log Pow <= 4).

12.4 Mobility in soil No data available(N,N-Dimethylpyridin-4-amine)


12.6 Other adverse effects No data available



Product Dissolve or mix the material with a combustible solvent and burn in a chem scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.


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14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (N,N-Dimethylpyridin-4-amine) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (N,N-Dimethylpyridin-4-amine) IATA: Toxic solid, organic, n.o.s. (N,N-Dimethylpyridin-4-amine)

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1









H301 Toxic if swallowed. H310 Fatal in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.


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Material Safety Data SheetPotassium carbonate, anhydrous MSDS


Product Name: Potassium carbonate, anhydrous

Catalog Codes: SLP4780, SLP1951, SLP3760, SLP5575

CAS#: 584-08-7

RTECS: TS7750000

TSCA: TSCA 8(b) inventory: Potassium carbonate,anhydrous

CI#: Not available.

Synonym: Salt of Tartar

Chemical Name: Potassium Carbonate

Chemical Formula: K2CO3









Composition:


Potassium carbonate, anhydrous 584-08-7 100

Toxicological Data on Ingredients: Potassium carbonate, anhydrous: ORAL (LD50): Acute: 1870 mg/kg [Rat].


Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of eyecontact (corrosive).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucous membranes. The substance may be toxic toskin, eyes. Repeated or prolonged exposure to the substance can produce target organs damage.


Eye Contact:

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Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention immediately.



















Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.


Precautions:

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Keep container dry. Do not ingest. Do not breathe dust. Never add water to this product. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, metals, acids.

Storage:Hygroscopic. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 25°C (77°F).







Physical state and appearance: Solid. (Powdered solid. Deliquescent solid.)

Odor: Odorless.



Color: White.


Boiling Point: Decomposes.











Solubility: Soluble in cold water.


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Conditions of Instability: Dust generation, moist air, water, incompatible materials

Incompatibility with various substances:Reactive with oxidizing agents, metals, acids. Slightly reactive to reactive with moisture.


Special Remarks on Reactivity:Hygroscopic. Reacts with water to evolve heat. Incompatible with KCO, chlorine trifluoride, calcium oxide, and magnesium.




Routes of Entry: Eye contact. Inhalation. Ingestion.


Chronic Effects on Humans:Causes damage to the following organs: mucous membranes. May cause damage to the following organs: skin, eyes.

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of eye contact (corrosive).



Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes severe skin irritation. Eyes: It is severely irritating to the eyes and its mucousmembranes. It may cause corneal injury. It may cause burns and loss of vision. It may cause permanent damage. The amountof tissue damage depends on the length of contact. Ingestion: It causes gastrointestinal irritation with nausea, vomiting,abdominal pain, swollen glottis, increased respiration, and possible burns to the lips, tongue, oral mucosa, hypopharynx,stomach, or esophagus. It may affect the cardiovascular system(circulatory collapse), urinary system, and metabolism.Inhalation: Causes respiratory tract and mucous membrane irritation. Exposure can cause coughing, chest pains, and difficultybreathing (dyspnea).









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Federal and State Regulations: TSCA 8(b) inventory: Potassium carbonate, anhydrous



WHMIS (Canada):CLASS D-2B: Material causing other toxic effects (TOXIC). CLASS E: Corrosive solid.

DSCL (EEC):R22- Harmful if swallowed. R37/38- Irritating to respiratory system and skin. R41- Risk of serious damage to eyes. S2- Keepout of the reach of children. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.S37/39- Wear suitable gloves and eye/face protection. S46- If swallowed, seek medical advice immediately and show thiscontainer or label.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 0

Reactivity: 1



Health: 2

Flammability: 0

Reactivity: 0

Specific hazard:





Created: 10/10/2005 11:40 AM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information for

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their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data SheetMethyl ethyl ketone MSDS


Product Name: Methyl ethyl ketone

Catalog Codes: SLM2626, SLM3232

CAS#: 78-93-3

RTECS: EL6475000

TSCA: TSCA 8(b) inventory: Methyl ethyl ketone


Synonym: 2-Butanone

Chemical Name: Methyl Ethyl Ketone

Chemical Formula: C4H8O









Composition:


Methyl ethyl ketone 78-93-3 100

Toxicological Data on Ingredients: Methyl ethyl ketone: ORAL (LD50): Acute: 2737 mg/kg [Rat]. 4050 mg/kg [Mouse].DERMAL (LD50): Acute: 6480 mg/kg [Rabbit]. VAPOR (LC50): Acute: 23500 mg/m 8 hours [Rat].


Potential Acute Health Effects:Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Classified POSSIBLE for human. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic togastrointestinal tract, upper respiratory tract, skin, eyes, central nervous system (CNS). Repeated or prolonged exposure tothe substance can produce target organs damage.


Eye Contact:

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Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.










Flash Points: CLOSED CUP: -9°C (15.8°F). OPEN CUP: -5.5556°C (22°F) (Tag).



Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Explosive in presence of oxidizing materials, of acids.


Special Remarks on Fire Hazards:Ignition on contact with potassium t-butoxide. Vapor may cause a flash fire

Special Remarks on Explosion Hazards:Reaction with Hydrogen Peroxide + nitric acid forms heat and shock-sensitive explosive product. Mixture with 2-propanol willproduce explosive peroxides during storage.



Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined

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areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.


Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, metals, acids, alkalis.






Exposure Limits:TWA: 200 STEL: 300 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 150 STEL: 300 (ppm) [Australia] TWA: 590 STEL:885 (mg/m3) from NIOSH TWA: 200 STEL: 300 (ppm) from NIOSH TWA: 590 STEL: 885 (mg/m3) [Canada] TWA: 200 STEL:300 (ppm) from OSHA (PEL) [United States] TWA: 590 STEL: 885 (mg/m3) from OSHA (PEL) [United States] Consult localauthorities for acceptable exposure limits.



Odor:Acetone-like Pleasant. Pungent. Sweetish. (Strong.)


Molecular Weight: 72.12g/mole



Boiling Point: 79.6 (175.3°F)


Critical Temperature: 262.5°C (504.5°F)

Specific Gravity: 0.805(Water = 1)



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Odor Threshold: 0.25 ppm

Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.3


Dispersion Properties: See solubility in water, diethyl ether, acetone.

Solubility: Soluble in cold water, diethyl ether, acetone.




Conditions of Instability: Heat, ignition sources, mechanical shock, incompatible materials.

Incompatibility with various substances: Reactive with oxidizing agents, metals, acids, alkalis.


Special Remarks on Reactivity:Incompatible with chloroform, copper, hydrogen peroxide, nitric acid, potassium t-butoxide, 2-propanol, chlorosulfonic acid,strong oxidizers, amines, ammonia, inorganic acids, isocyanates, caustics, pyrindines. Vigorous reaction with chloroform+alkali.





Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 2737 mg/kg [Rat]. Acute dermal toxicity (LD50): 6480 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 32000mg/m3 4 hours [Mouse].

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified POSSIBLE for human.May cause damage to the following organs: gastrointestinal tract, upper respiratory tract, skin, eyes, central nervous system(CNS).

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation (lungirritant).


Special Remarks on Chronic Effects on Humans: May cause birth defects based on animal dats. Embryotoxic and/orfoetotoxic in animal.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. May be absorbed through the skin. Eyes: Causes eye irritation.Inhalation: Inhalation of high concentrations may cause central nervous effects characterized by headache, dizziness,unconsciousness, and coma. Causes respiratory tract irritation and affects the sense organs. May affect the liver and urinarysystem. Ingestion: Causes gastrointestinal tract irritation with nausea, vomiting and diarrhea. May affect the liver. ChronicPotential Health Effects: Chronic inhalation may cause effects similar to those of acute inhalation. Prolonged or repeated skincontact may cause defatting and dermatitis.

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Ecotoxicity: Ecotoxicity in water (LC50): 3220 mg/l 96 hours [Fathead Minnow]. 1690 mg/l 96 hours [Bluegill].









Identification: : Ethyl methyl ketone UNNA: 1193 PG: II



Federal and State Regulations:New York release reporting list: Methyl ethyl ketone Rhode Island RTK hazardous substances: Methyl ethyl ketonePennsylvania RTK: Methyl ethyl ketone Minnesota: Methyl ethyl ketone Massachusetts RTK: Methyl ethyl ketone New Jersey:Methyl ethyl ketone California Director's list of Hazardous Substances: Methyl ethyl ketone TSCA 8(b) inventory: Methyl ethylketone TSCA 8(d) H and S data reporting: Methyl ethyl ketone: Effective: 10/4/82; Sunset: 10/4/92 SARA 313 toxic chemicalnotification and release reporting: Methyl ethyl ketone CERCLA: Hazardous substances.: Methyl ethyl ketone: 5000 lbs. (2268kg)



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC).

DSCL (EEC):R11- Highly flammable. R36/37- Irritating to eyes and respiratory system. S9- Keep container in a well-ventilated place. S16-Keep away from sources of ignition - No smoking. S25- Avoid contact with eyes. S33- Take precautionary measures againststatic discharges.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0


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Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:





Created: 10/10/2005 08:39 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetDimethyl sulfoxide MSDS


Product Name: Dimethyl sulfoxide

Catalog Codes: SLD3139, SLD1015

CAS#: 67-68-5

RTECS: PV6210000

TSCA: TSCA 8(b) inventory: Dimethyl sulfoxide


Synonym: Methyl Sulfoxide; DMSO

Chemical Name: Dimethyl Sulfoxide

Chemical Formula: (CH3)2SO









Composition:


Dimethyl sulfoxide 67-68-5 100

Toxicological Data on Ingredients: Dimethyl sulfoxide: ORAL (LD50): Acute: 14500 mg/kg [Rat]. 7920 mg/kg [Mouse].DERMAL (LD50): Acute: 40000 mg/kg [Rat].


Potential Acute Health Effects:Slightly hazardous in case of inhalation (lung irritant). Slightly hazardous in case of skin contact (irritant, permeator), of eyecontact (irritant), of ingestion, .

Potential Chronic Health Effects:Slightly hazardous in case of skin contact (irritant, sensitizer, permeator), of ingestion. CARCINOGENIC EFFECTS:Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic toblood, kidneys, liver, mucous membranes, skin, eyes. Repeated or prolonged exposure to the substance can produce targetorgans damage.


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Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention if irritation occurs.








Flammability of the Product: Combustible.


Flash Points: CLOSED CUP: 89°C (192.2°F). OPEN CUP: 95°C (203°F).

Flammable Limits: LOWER: 2.6% UPPER: 28.5% (Lewis), 42% (NFPA)

Products of Combustion: These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).

Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.



Special Remarks on Fire Hazards:When heated above its boiling point, dimethyl sulfoxide degrades giving off formaldehyde, methyl mercaptan, and sulfurdioxide



Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authorityrequirements.

Large Spill:Combustible material. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. If the product is inits solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is in its liquid form:Absorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by spreading wateron the contaminated surface and allow to evacuate through the sanitary system.

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Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatiblessuch as oxidizing agents.

Storage:Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possiblesources of ignition (spark or flame). Hygroscopic. Sensitive to light. Store in light-resistant containers.



Personal Protection:Safety glasses. Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves(impervious).





Odor: Sulfurous. (Slight.)

Taste: Bitter with sweet after-taste (Slight.)





Melting Point: 18.45°C (65.2°F)







Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -2



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Solubility:Soluble in cold water, hot water, diethyl ether, acetone. Soluble in chloroform, ethanol, and benzene.




Conditions of Instability: Heat, ignition sources, flames, incompatibles

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.


Special Remarks on Reactivity:Hygroscopic. It has a strong water affinity, and if left exposed it will become rapidly diluted. Incompatible with strong oxidants,arylhalides, bromobenzoyl acetanilide, magnesium perchlorate, perchloric acid, and sodium hydroxide, alkali metals,hydrobromic acid, acidic solutions of alkali bromides, organic and inorganic acid chlorides, acid halides, cyanuric chloride,silver fluoride, methyl bromide, sodium hydride, periodic acid, diborane, iodine pentafluoride, silicon tetrachloride, phosphoroushalides (phosphorous trichloride), trichloroacetic acid + copper wool, phosphorous trioxide, thionyl chloride, plastics




Routes of Entry: Absorbed through skin. Eye contact. Inhalation.

Toxicity to Animals:Acute oral toxicity (LD50): 7920 mg/kg [Mouse]. Acute dermal toxicity (LD50): 40000 mg/kg [Rat].

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage tothe following organs: blood, kidneys, liver, mucous membranes, skin, eyes.

Other Toxic Effects on Humans:Slightly hazardous in case of inhalation (lung irritant). Slightly hazardous in case of skin contact (irritant, permeator), ofingestion, .


Special Remarks on Chronic Effects on Humans:May cause adverse reproductive effects (female fertility and fetotoxicity - post implantation mortality) and birth defects basedon animal data. May cause cancer (tumorigenic) based on animal data. May affect genetic material (mutagenic).

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. May cause urticaria(hives), skin rashes, and dermatitis. DimethylSulfoxide is readily absorbed through skin and may carry other dissolved chemicals into the body. An unusual garlic-onion-oyster odor may develop on breath and body/skin. Absorption through skin may also cause diarrhea, and affectrespiration(dyspnea, cyanosis), blood, behavior (fatigue, dizziness, sedation, headaches), vision (transient photophobia,and disturbances of color vision), urinary system (hematuria). Eyes: Causes eye irritation. May cause blurred vision,corneal opacity, chemical conjunctivitis. Inhalation: Causes respiratory tract irritation. Symptoms from exposure to highvapor concentrations may include coughing, shortness of breath, headache, dizziness and sedation. Ingestion: Causesgastrointestinal tract irritation, and an usual garlic-onion-oyster may develop on breath, and body/skin. May affect behavior/central nervous system, respiration (dyspnea). Symptoms may include nausea, vomiting, and diarrhea, abdominal pain,drowsiness, confusion, lethargy, agitation, disorientation, tremor, muscle weakness, chills, chest pains. May also affect liver(elevated liver enzymes, jaundice), cardiovascular system, and urinary system (hematuria, hemoglobinuria, renal tubularinjury), eyes (transient photophobia and disturbances of color vision, conjunctive irritation) Chronic Potential Health Effects:Skin: Chronic absorption may cause effects similar to that of acute skin absorption. Chronic skin contact may cause scaling

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dermatitis. Ingestion: Repeated oral doses may affect the kidneys (hematuria), blood (normocytic anemia, changes in redblood cell count), and metabolism (weight loss/anorexia), liver (jaundice).














Federal and State Regulations: TSCA 8(b) inventory: Dimethyl sulfoxide

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances. National Inventory Lists of China, Japan, Korea, andPhilippines.


WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F).

DSCL (EEC):R36/37/38- Irritating to eyes, respiratory system and skin. S26- In case of contact with eyes, rinse immediately with plenty ofwater and seek medical advice. S36/37/39- Wear suitable protective clothing, gloves and eye/face protection.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 2

Reactivity: 0

Personal Protection: F


Health: 2

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Flammability: 2

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves (impervious). Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wearappropriate respirator when ventilation is inadequate. Safety glasses.




Created: 10/10/2005 08:37 PM

Last Updated: 05/21/2013 12:00 PM


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Sigma-Aldrich - 271004 Page 1 of 8





1.1 Product identifiers Product name : Acetonitrile

Product Number : 271004 Brand : Sigma-Aldrich Index-No. : 608-001-00-3 REACH No. : 01-2119471307-38-XXXX

CAS-No. : 75-05-8









Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Eye irritation (Category 2), H319


2.2 Label elements


Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled H319 Causes serious eye irritation.

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Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none



3.1 Substances Synonyms : Methyl cyanide

ACN

Formula : C2H3N




Acetonitrile


75-05-8 200-835-2 608-001-00-3 01-2119471307-38-XXXX

Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; H225, H302, H332, H312, H319

<= 100 %






In case of skin contact Wash off with soap and plenty of water. Consult a physician.




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6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.







Handle and store under inert gas. Storage class (TRGS 510): Flammable liquids






Health effect Value

Workers Inhalation Acute local effects, Acute systemic effects

68 mg/m3

Workers Skin contact Long-term systemic effects 32.2mg/kg BW/d

Workers Inhalation Long-term local effects, Long-term 68 mg/m3

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systemic effects

Consumers Inhalation Acute local effects 220 mg/m3

Consumers Inhalation Acute systemic effects 22 mg/m3

Consumers Inhalation Long-term systemic effects 4.8 mg/m3


Compartment Value

Water 10 mg/l

Soil 2.41 mg/kg

Marine water 1 mg/l

Fresh water 10 mg/l


Onsite sewage treatment plant 32 mg/l







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a) Appearance Form: clear, liquid Colour: colourless

b) Odour ether-like


d) pH No data available


Melting point/range: -48 °C


81 - 82 °C

g) Flash point 2.0 °C - closed cup

h) Evaporation rate 5.8



Upper explosion limit: 16 %(V) Lower explosion limit: 3 %(V)

k) Vapour pressure 73.18 hPa at 15 °C 121.44 hPa at 25 °C 413.23 hPa at 55 °C 98.64 hPa at 20 °C


m) Relative density 0.786 g/mL at 25 °C

n) Water solubility completely soluble


log Pow: -0.54 at 25 °C


524.0 °C


No data available


s) Explosive properties Not explosive

t) Oxidizing properties The substance or mixture is not classified as oxidizing.


Surface tension 29.0 mN/m at 20.0 °C





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10.4 Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight.

10.5 Incompatible materials acids, Bases, Oxidizing agents, Reducing agents, Alkali metals

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - male - 1,320 - 6,690 mg/kg(Acetonitrile) LC50 Inhalation - Mouse - 4 h - 3587 ppm(Acetonitrile) (OECD Test Guideline 403) LC50 Inhalation - Rat - 4 h - 26.8 mg/l(Acetonitrile) LD50 Dermal - Rabbit - male and female - > 2,000 mg/kg(Acetonitrile) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Acetonitrile) Result: No skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Acetonitrile) Result: Irritating to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitisation Buehler Test - Guinea pig(Acetonitrile) Did not cause sensitisation on laboratory animals. (OECD Test Guideline 406)

Germ cell mutagenicity Hamster(Acetonitrile) ovary Result: negative Mutation in mammalian somatic cells. Ames test(Acetonitrile) S. typhimurium Result: Not mutagenic in Ames Test Hamster(Acetonitrile) ovary Result: Equivocal evidence. Sister chromatid exchange Mutagenicity (micronucleus test)(Acetonitrile) Mouse Result: Positive results were obtained in some in vivo tests.

Carcinogenicity No evidence of carcinogenicity in animal studies.(Acetonitrile)


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Animal testing did not show any effects on fertility.(Acetonitrile)

Specific target organ toxicity - single exposure The substance or mixture is not classified as specific target organ toxicant, single exposure.(Acetonitrile)

Specific target organ toxicity - repeated exposure The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard No aspiration toxicity classification(Acetonitrile)

Additional Information RTECS: AL7700000 Treat as cyanide poisoning., Always have on hand a cyanide first-aid kit, together with proper instructions., The onset of symptoms is generally delayed pending conversion to cyanide., Nausea, Vomiting, Diarrhoea, Headache, Dizziness, Rash, Cyanosis, excitement, depression, Drowsiness, impaired judgment, Lack of coordination, stupor, death(Acetonitrile)


12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 1,640.00 mg/l - 96

h(Acetonitrile) NOEC - Oryzias latipes - 102 mg/l - 21 d(Acetonitrile) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 3,600 mg/l - 48 h(Acetonitrile) (OECD Test Guideline 202)

NOEC - Daphnia magna (Water flea) - 160 mg/l - 21 d(Acetonitrile)

12.2 Persistence and degradability Biodegradability Result: 84 % - Readily biodegradable

(OECD Test Guideline 301C)


12.4 Mobility in soil Not expected to adsorb on soil.(Acetonitrile)


12.6 Other adverse effects Avoid release to the environment. Stability in water (Acetonitrile)

Remarks: Hydrolyses slowly.





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14.2 UN proper shipping name ADR/RID: ACETONITRILE IMDG: ACETONITRILE IATA: Acetonitrile










H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H302 + H312 + H332

Harmful if swallowed, in contact with skin or if inhaled

H312 Harmful in contact with skin. H319 Causes serious eye irritation. H332 Harmful if inhaled.


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Material Safety Data SheetEthyl acetate MSDS


Product Name: Ethyl acetate

Catalog Codes: SLE2452, SLE2317

CAS#: 141-78-6

RTECS: AH5425000

TSCA: TSCA 8(b) inventory: Ethyl acetate

CI#: Not available.

Synonym: Acetic Acid, Ethyl Ester Acetic Ether

Chemical Name: Ethyl Acetate










Composition:


Ethyl acetate 141-78-6 100

Toxicological Data on Ingredients: Ethyl acetate: ORAL (LD50): Acute: 5620 mg/kg [Rat]. 4100 mg/kg [Mouse]. 4935 mg/kg[Rabbit]. VAPOR (LC50): Acute: 45000 mg/m 3 hours [Mouse]. 16000 ppm 6 hours [Rat].


Potential Acute Health Effects:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact(irritant).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucousmembranes, upper respiratory tract. The substance may be toxic to blood, kidneys, liver, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.


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Auto-Ignition Temperature: 426.67°C (800°F)

Flash Points: CLOSED CUP: -4.4°C (24.1°F). (TAG) OPEN CUP: 7.2°C (45°F) (Cleveland).



Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizingmaterials, of acids, of alkalis. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of heat. Non-explosive in presence of shocks.


Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. When heated to decomposition it emits acridsmoke and irritating fumes.

Special Remarks on Explosion Hazards:The liquid produces a vapor that forms explosive mixtures with air at normal temperatures. Explosive reaction with lithiumtetrahydroaluminate.



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Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatiblessuch as oxidizing agents, acids, alkalis.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.



Personal Protection:Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.


Exposure Limits:TWA: 400 (ppm) from OSHA (PEL) [United States] TWA: 400 from ACGIH (TLV) [United States] TWA: 1400 (mg/m3) fromNIOSH [United States] TWA: 400 (ppm) from NIOSH [United States] TWA: 400 (ppm) [Canada] TWA: 1440 (mg/m3) [Canada]TWA: 1400 (mg/m3) from OSHA (PEL) [United States]3 Consult local authorities for acceptable exposure limits.



Odor: Ethereal. Fruity. (Slight.)

Taste: Bittersweet, wine-like burning taste


Color: Colorless.







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Solubility: Soluble in cold water, hot water, diethyl ether, acetone, alcohol, benzene.




Conditions of Instability: Heat, ignition sources (flames, sparks, static), incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.


Special Remarks on Reactivity:Also incompatible with nitrates, chlorosulfonic acid, oleum, potassium-tert-butoxide, and lithium tetrahydroaluminate. Moisturesensitive. On storage, it is slowly decomposed by water.




Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 4100 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 45000 mg/m3 3 hours [Mouse].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. Causes damage to the following organs:mucous membranes, upper respiratory tract. May cause damage to the following organs: blood, kidneys, liver, central nervoussystem (CNS).

Other Toxic Effects on Humans:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator).

Special Remarks on Toxicity to Animals: LD50 [Rabbit] - Route: skin; Dose >20,000 ml/kg

Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenic). May cause adverse reproductive effects. based on animal test data. No human datafound at this time.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: Causes eye irritation. May cause irritation of theconjunctivia. Inhalation: May cause respiratory tract and mucous membrane irritation. May affect respiration and may causeacute pulmonary edema. May affect gastrointestinal tract (nausea, vomiting). May affect behavior/central nervous system(mild central nervous system depression - exhilaration, talkativeness, boastfulness, belligerancy, vertigo, diplopia, drowsiness,slurred speech, slowed reaction time, dizziness, lightheadedness, somnolence, ataxia, unconciousness, irritability, fatigue,sleep disturbances, reduced memory and concentration, stupor, coma), cardiovascular system (peripheral vascular collapse(shock) - rapid pulse, hypotension, cold pale skin, hypothermia). Other symptoms may include: flushing of face and sweating.

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Ingestion: May cause gastrointestinal tract irritation with nausea and vomiting. May affect blood, behavior/central nervoussystem (CNS depression - effects may be similar to that of inhalation). Chronic Potential Health Effects: Skin: Repeated orprolonged skin contact may cause drying and cracking of the skin. IngestIon: Prolonged or repeated ingestion may affectthe liver. Inhalation: Prolonged inhalation may affect behavior/central nervous system (symptoms similar to those of acuteinhalation), and cause liver, kidney, lung, and heart damage. It may also affect metabolism, and blood (anemia, leukocytosis).


Ecotoxicity:Ecotoxicity in water (LC50): 220 mg/l 96 hours [Fish (Fathead minnow)]. 212.5 ppm 96 hours [Fish (Indian catfish)].









Identification: : Ethyl Acetate UNNA: 1173 PG: II



Federal and State Regulations:Connecticut hazardous material survey.: Ethyl acetate Illinois toxic substances disclosure to employee act: Ethyl acetateIllinois chemical safety act: Ethyl acetate New York release reporting list: Ethyl acetate Rhode Island RTK hazardoussubstances: Ethyl acetate Pennsylvania RTK: Ethyl acetate Florida: Ethyl acetate Minnesota: Ethyl acetate MassachusettsRTK: Ethyl acetate Massachusetts spill list: Ethyl acetate New Jersey: Ethyl acetate New Jersey spill list: Ethyl acetateLouisiana spill reporting: Ethyl acetate California Director's list of Hazardous Substances: Ethyl acetate TSCA 8(b) inventory:Ethyl acetate TSCA 4(a) final test rules: Ethyl acetate TSCA 8(a) IUR: Ethyl acetate TSCA 12(b) annual export notification:Ethyl acetate CERCLA: Hazardous substances.: Ethyl acetate: 5000 lbs. (2268 kg)



WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).

DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S2- Keep out of the reach of children. S16- Keep away from sources of ignition- No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33-Take precautionary measures against static discharges. S46- If swallowed, seek medical advice immediately and show thiscontainer or label.

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HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0

Personal Protection: g


Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Safety glasses.




Created: 10/10/2005 08:18 PM

Last Updated: 05/21/2013 12:00 PM


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1.1 Product identifiers Product name : Cinnamyl alcohol



CAS-No. : 104-54-1









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Skin sensitisation (Category 1), H317


2.2 Label elements


Signal word Warning Hazard statement(s) H302 Harmful if swallowed. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation.

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Precautionary statement(s) P280 Wear protective gloves. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none



3.1 Substances Synonyms : 3-Phenyl-2-propen-1-ol

Formula : C9H10O



Cinnamyl alcohol

CAS-No. EC-No.

104-54-1 203-212-3

Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; H302, H315, H319, H317

<= 100 %














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5.2 Special hazards arising from the substance or mixture Carbon oxides




6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8.






7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids








Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Chloroprene Minimum layer thickness: 0.6 mm

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Break through time: 480 min Material tested:Camapren® (KCL 722 / Aldrich Z677493, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 30 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).




a) Appearance Form: Solidified mass or fragments Colour: colourless





Melting point/range: 30 - 33 °C - lit.


250 °C - lit.





No data available

k) Vapour pressure < 0.01 mmHg at 25 °C



n) Water solubility No data available


No data available


No data available

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No data available




9.2 Other safety information No data available






10.5 Incompatible materials Oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 2,000 mg/kg(Cinnamyl alcohol) LD50 Dermal - Rabbit - > 5,000 mg/kg(Cinnamyl alcohol)

Skin corrosion/irritation Skin - Rabbit(Cinnamyl alcohol) Result: Skin irritation - 24 h

Serious eye damage/eye irritation No data available(Cinnamyl alcohol)

Respiratory or skin sensitisation No data available(Cinnamyl alcohol)

Germ cell mutagenicity No data available(Cinnamyl alcohol)

Carcinogenicity


Reproductive toxicity No data available(Cinnamyl alcohol)

Specific target organ toxicity - single exposure No data available(Cinnamyl alcohol)


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Aspiration hazard No data available(Cinnamyl alcohol)

Additional Information RTECS: GE2200000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Cinnamyl alcohol)





12.4 Mobility in soil No data available(Cinnamyl alcohol)





Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.



14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -



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H302 Harmful if swallowed. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation.


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Material Safety Data SheetSodium methoxide MSDS


Product Name: Sodium methoxide

Catalog Codes: SLS4279, SLS3199

CAS#: 124-41-4

RTECS: PC3570000

TSCA: TSCA 8(b) inventory: Sodium methoxide


Synonym: Methanol, sodium salt; Sodium Methylate

Chemical Name: Sodium methoxide

Chemical Formula: CH3ONa









Composition:


Sodium methoxide 124-41-4 100

Toxicological Data on Ingredients: Sodium methoxide: ORAL (LD50): Acute: 2037 mg/kg [Rat].


Potential Acute Health Effects:Hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (irritant, corrosive), of ingestion,of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage orblindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal orrespiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking,unconsciousness or death.

Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated exposureof the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, ordermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.


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Flash Points: CLOSED CUP: 33°C (91.4°F).



Fire Hazards in Presence of Various Substances:Highly flammable in presence of moisture. Flammable in presence of open flames and sparks, of heat.


Fire Fighting Media and Instructions:Flammable solid. Moisture reactive material. SMALL FIRE: Obtain advice on use of water. Use DRY chemical powder. LARGEFIRE: Use water spray or fog. Do not use water jet.

Special Remarks on Fire Hazards:Dangerous. It ignites spontaneously in moist air. This material is pyrophoric (ignites spontaneously in air) at temperaturesapproximately 50 deg. C and above.

Special Remarks on Explosion Hazards:Material in powder form, capable of creating a dust explosion. Sodium methylate and Methyl azide + Dimethyl Malonate maycause an explosion. Sodium Methylate and Perchloryl Fluoride + Methyl alcohol may cause an explosion. To rapid of anaddition of Sodium Methylate to a mixture of chloroform and methanol may cause an explosion.


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Large Spill:Corrosive solid. Flammable solid that, in contact with water, emits flammable gases. Stop leak if without risk. Do not get waterinside container. Do not touch spilled material. Cover with dry earth, sand or other non-combustible material. Use water sprayto reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Callfor assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on theMSDS and with local authorities.


Precautions:Keep under inert atmosphere. Keep container dry. Do not ingest. Do not breathe dust. Never add water to this product. Incase of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and showthe container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids,moisture.

Storage:Moisture sensitive. Air Sensitive. Store in a segregated and approved area. Keep in a cool and ventilated area away fromcombustible materials. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready foruse. Avoid all possible sources of ignition (spark or flame).





Exposure Limits:Exposure LImit Information for Dust or Particulates Not Otherwise Classified: TWA: 10 (mg/m3) from ACGIH (TLV) [UnitedStates] Inhalation Total. TWA: 3 (mg/m3) from ACGIH (TLV) [United States] Inhalation Respirable. TWA: 15 (mg/m3) fromOSHA (PEL) [United States] Inhalation Total. TWA: 5 (mg/m3) from OSHA (PEL) [United States] Inhalation Respirable.Consultlocal authorities for acceptable exposure limits.


Physical state and appearance:Solid. (Solid powder. Amorphous solid powder or lumps. )




Color: White.


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Melting Point: Decomposition temperature: >126°C (258.8°F)









Dispersion Properties: See solubility in water, methanol.

Solubility:Soluble in cold water, methanol. Soluble in ethanol. Decomposes/reacts in water.




Conditions of Instability: Excess heat, air, moisture, water,incompatible materials.

Incompatibility with various substances:Reactive with oxidizing agents, acids, moisture. The product reacts violently with water to emit flammable but non toxic gases.


Special Remarks on Reactivity:Moisture sensitive Air sensitive. Also incompatible with chlorinated solvents, chloroform, 4-chloronitrobenzene,perfluorocyclopropane, liquid metals. Attacks some forms of plastics, rubbers, and coatings. Sodium Methylate + waterproduces a caustic soda solution and a solution of methyl alcohol. The reaction is not violent. When heated to decompositionit emits toxic fumes.







Other Toxic Effects on Humans:Hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (corrosive), of ingestion, ofinhalation (lung corrosive).



Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Casues severe skin irritation and burns. Eyes: Causes severe eye irritation and burns.May cause eye injury Inhalation: Material is destructive to tissue of the mucous membranes and upper respiratory tract. It

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may cause severe irritation to the respiratory tract and chemical burns to the respiratory tract. Symptoms may include sorethroat, burning sensation, coughing, wheezing, labored breathing, and possible pulmonary edema. Ingeston: Causes mouth,esophagus, pharyns, and gastrointestinal tract irritation and burns. Symptoms may include sore throat, vomiting diarrhea, andabdominal pain. It may also affect respiration(dyspnea), and behavior (ataxia). Chronic Potential Health Effects: Repeated orprolonged skin contact may cause dermitits, an allergic reaction.It may cause severe and permanent damage to the digestivetract.










DOT Classification:CLASS 4.2: Spontaneously combustible substance. Class 8: Corrosive material

Identification: : Sodium methylate UNNA: 1431 PG: II



Federal and State Regulations:Connecticut hazardous material survey.: Sodium methoxide Illinois toxic substances disclosure to employee act: Sodiummethoxide Illinois chemical safety act: Sodium methoxide New York release reporting list: Sodium methoxide PennsylvaniaRTK: Sodium methoxide Massachusetts RTK: Sodium methoxide Massachusetts spill list: Sodium methoxide New Jersey:Sodium methoxide New Jersey spill list: Sodium methoxide Louisiana spill reporting: Sodium methoxide California Director'sList of Hazardous Substances: Sodium methoxide TSCA 8(b) inventory: Sodium methoxide CERCLA: Hazardous substances.:Sodium methoxide: 1000 lbs. (453.6 kg)



WHMIS (Canada):CLASS B-6: Reactive and very flammable material. CLASS E: Corrosive solid.

DSCL (EEC):

HMIS (U.S.A.):

Health Hazard: 2

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Fire Hazard: 2

Reactivity: 2



Health: 3

Flammability: 2

Reactivity: 2

Specific hazard:



References:-SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -The Sigma-AldrichLibrary of Chemical Safety Data, Edition II.


Created: 10/10/2005 08:34 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetSodium Ethoxide MSDS


Product Name: Sodium Ethoxide

Catalog Codes: SLS2428

CAS#: 141-52-6

RTECS: Not available.

TSCA: TSCA 8(b) inventory: Sodium Ethoxide

CI#: Not available.

Synonym: Sodium Ethylate; Sodium Ethanolate; Ethanol,sodium salt

Chemical Name: Sodium Ethoxide

Chemical Formula: C2-H5-O-Na









Composition:


Sodium Ethoxide 141-52-6 100

Toxicological Data on Ingredients: Sodium Ethoxide LD50: Not available. LC50: Not available.


Potential Acute Health Effects:Hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant, corrosive), of ingestion, of inhalation. Theamount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skincontact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratorytract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking,unconsciousness or death.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated exposure of the eyes to a low level of dust can produce eye irritation.Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varyingdegree of respiratory irritation or lung damage.


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Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention immediately.

Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Getmedical attention immediately.














Fire Fighting Media and Instructions:Flammable solid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.





Large Spill:Corrosive solid. Flammable solid that, in contact with water, emits flammable gases. Stop leak if without risk. Do not get waterinside container. Do not touch spilled material. Cover with dry earth, sand or other non-combustible material. Use water spray

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to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Callfor assistance on disposal.


Precautions:Keep under inert atmosphere. Keep container dry. Do not breathe dust. Never add water to this product. In case of insufficientventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible.Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids.

Storage:Keep container tightly closed. Keep container in a cool, well-ventilated area. Keep from any possible contact with water. Donot allow water to get into container because of violent reaction. Do not store above 24°C (75.2°F).







Physical state and appearance: Solid. (Powdered solid.)







Melting Point: 260°C (500°F)


Specific Gravity: Not available.






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Conditions of Instability: Heat, ingnition sources, incompatible materials, dust generation, moisture, light, air.

Incompatibility with various substances:Reactive with oxidizing agents, acids. Slightly reactive to reactive with moisture. The product reacts violently with water to emitflammable but non toxic gases.


Special Remarks on Reactivity:Hygroscopic (Moisture Sensitive. Air Sensitive. Light Sensitive. It decomposes on exposure to air and becomes darker onkeeping. May react with water (decomposed by water) to form a caustic soda solution (sodium hydroxide) and ethanol. Reactsviolently with water, acids, and chlorinated solvents.




Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.



Other Toxic Effects on Humans:Hazardous in case of skin contact (corrosive, irritant), of eye contact (corrosive), of ingestion, of inhalation (lung corrosive).



Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation and burns. Eyes: Cause eye irritation and burns Inhalation: Harmfulif inhaled. May cause severe irritation of the respiratory tract and mucous membranes. May cause chemical burns to therespiratory tract. Symptoms may include sore throat, coughing, shortness of breath, and delayed lung edema, inflammationand edema of the larynx and bronchi, chemical pneumonitis, burning sensation, spasm, shortness of breath Ingestion: Harmfulif swallowed. May cause severe gastrointestinal tract irritation with possible burns. May cause severe and permanent damageto the digestive tract. Symptoms may include nausea, vomiting, diarrhea. Chronic Potential Health Effects: no informationfound at this time. The toxicological properties of this substance have not been fully investigated.




Products of Biodegradation:

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Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.






DOT Classification:CLASS 4.2: Spontaneously combustible substance. Class 8: Corrosive material

Identification: : Alkali Metal Alcoholate, self heating, corrosive, n.o.s. (Sodium Ethoxide) UNNA: 3206 PG: II



Federal and State Regulations: TSCA 8(b) inventory: Sodium Ethoxide




DSCL (EEC):R11- Highly flammable. R14- Reacts violently with water. R34- Causes burns. S8- Keep container dry. S16- Keep away fromsources of ignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medicaladvice. S27- Take off immediately all contaminated clothing. S36/37/39- Wear suitable protective clothing, gloves and eye/faceprotection. S43- In case of fire, use dry chemical (never use water) S45- In case of accident or if you feel unwell, seek medicaladvice immediately (show the label where possible).

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 2

Reactivity: 1



Health: 2

Flammability: 2

Reactivity: 1

Specific hazard:


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Created: 10/09/2005 06:31 PM

Last Updated: 05/21/2013 12:00 PM


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1.1 Product identifiers Product name : Ammonia

Product Number : 294993 Brand : Aldrich Index-No. : 007-001-00-5 REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 7664-41-7









Classification according to Regulation (EC) No 1272/2008 Flammable gases (Category 2), H221 Gases under pressure (Compressed gas), H280 Acute toxicity, Inhalation (Category 3), H331 Skin corrosion (Category 1B), H314 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410


2.2 Label elements


Signal word Danger Hazard statement(s) H221 Flammable gas.

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H280 Contains gas under pressure; may explode if heated. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P261 Avoid breathing gas. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor. Supplemental Hazard Statements

none



3.1 Substances Formula : H<SB>3</>N Molecular weight : 17.03 g/mol CAS-No. : 7664-41-7 EC-No. : 231-635-3 Index-No. : 007-001-00-5 Hazardous ingredients according to Regulation (EC) No 1272/2008


Ammonia, anhydrous


7664-41-7 231-635-3 007-001-00-5

Flam. Gas 2; Press. Gas Compr. Gas; Acute Tox. 3; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1; H221, H280, H331, H314, H400, H410

M-Factor - Aquatic Acute: 1

<= 100 %








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5.2 Special hazards arising from the substance or mixture Nitrogen oxides (NOx)










7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Contents under pressure. Storage class (TRGS 510): Gases


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Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).




a) Appearance Form: Compressed gas

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Melting point/range: -78 °C - lit.


-33 °C - lit.






k) Vapour pressure 4,802 mmHg at 15.50 °C 6,650 mmHg at 21 °C


m) Relative density 0.590 g/cm3



No data available


No data available


No data available











10.5 Incompatible materials Oxidizing agents, Iron, Zinc, Copper, Silver/silver oxides, Cadmium/cadmium oxides, Alcohols, acids, Halogens, Aldehydes

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

Page 201 of 485




Acute toxicity No data availableAmmonia, anhydrous LC50 Inhalation - Rat - 4 h - 2000 ppm(Ammonia, anhydrous)

Skin corrosion/irritation No data available(Ammonia, anhydrous)

Serious eye damage/eye irritation No data available(Ammonia, anhydrous)

Respiratory or skin sensitisation No data available(Ammonia, anhydrous)

Germ cell mutagenicity No data available(Ammonia, anhydrous)

Carcinogenicity


Reproductive toxicity No data available(Ammonia, anhydrous)

Specific target organ toxicity - single exposure No data available(Ammonia, anhydrous)


Aspiration hazard No data available(Ammonia, anhydrous)

Additional Information RTECS: BO0875000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Ammonia, anhydrous) Liver - Irregularities - Based on Human Evidence(Ammonia, anhydrous)


12.1 Toxicity No data available Toxicity to daphnia and other aquatic invertebrates

LC50 - Daphnia magna (Water flea) - 25.4 mg/l - 48 h(Ammonia, anhydrous)



12.4 Mobility in soil No data available(Ammonia, anhydrous)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and

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toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Very toxic to aquatic life with long lasting effects. No data available







14.2 UN proper shipping name ADR/RID: AMMONIA, ANHYDROUS IMDG: AMMONIA, ANHYDROUS IATA: Ammonia, anhydrous Passenger Aircraft: Not permitted for transport Cargo Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 2.3 (8) IMDG: 2.3 (8) IATA: 2.3 (8)


14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: yes IATA: no







H221 Flammable gas. H280 Contains gas under pressure; may explode if heated. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held

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liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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1.1 Product identifiers Product name : Methanol

Product Number : 322415 Brand : Sigma-Aldrich Index-No. : 603-001-00-X REACH No. : 01-2119433307-44-XXXX

CAS-No. : 67-56-1









Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Specific target organ toxicity - single exposure (Category 1), H370


2.2 Label elements


Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H370 Causes damage to organs.

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Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if

you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none



3.1 Substances Synonyms : Methyl alcohol

Formula : CH4O

Molecular weight : 32.04 g/mol CAS-No. : 67-56-1 EC-No. : 200-659-6 Index-No. : 603-001-00-X Registration number : 01-2119433307-44-XXXX

No components need to be disclosed according to the applicable regulations.







In case of eye contact Flush eyes with water as a precaution.


Notes to physician Dizziness Drowsiness metabolic acidosis Blurred vision Seizures. Coma Blindness death



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7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids






Health effect Value

Workers Skin contact Long-term systemic effects 40mg/kg BW/d

Consumers Skin contact Long-term systemic effects 8mg/kg BW/d

Consumers Ingestion Long-term systemic effects 8mg/kg BW/d

Workers Skin contact Acute systemic effects 40mg/kg BW/d

Consumers Skin contact Acute systemic effects 8mg/kg BW/d

Consumers Ingestion Acute systemic effects 8mg/kg BW/d

Workers Inhalation Acute systemic effects 260 mg/m3

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Workers Inhalation Acute local effects 260 mg/m3

Workers Inhalation Long-term systemic effects 260 mg/m3

Workers Inhalation Long-term local effects 260 mg/m3

Consumers Inhalation Acute systemic effects 50 mg/m3

Consumers Inhalation Acute local effects 50 mg/m3

Consumers Inhalation Long-term systemic effects 50 mg/m3

Consumers Inhalation Long-term local effects 50 mg/m3


Compartment Value

Soil 23.5 mg/kg


Fresh water 154 mg/l


Onsite sewage treatment plant 100 mg/kg





Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 31 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air

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respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).




a) Appearance Form: liquid Colour: colourless

b) Odour pungent






64.7 °C






k) Vapour pressure 97.7 mmHg at 20.0 °C 410.0 mmHg at 50.0 °C 169.27 hPa at 25.0 °C

l) Vapour density 1.11


n) Water solubility completely miscible


log Pow: -0.77


455.0 °C at 1,013 hPa


No data available


s) Explosive properties Not explosive

t) Oxidizing properties The substance or mixture is not classified as oxidizing.


Minimum ignition energy 0.14 mJ

Conductivity < 1 µS/cm

Relative vapour density 1.11



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10.5 Incompatible materials Acid chlorides, Acid anhydrides, Oxidizing agents, Alkali metals, Reducing agents, Acids




Acute toxicity

Skin corrosion/irritation

Serious eye damage/eye irritation

Respiratory or skin sensitisation

Germ cell mutagenicity

Carcinogenicity



Specific target organ toxicity - single exposure

Specific target organ toxicity - repeated exposure

Aspiration hazard

Additional Information RTECS: PC1400000


12.1 Toxicity

12.2 Persistence and degradability

12.3 Bioaccumulative potential

12.4 Mobility in soil


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12.6 Other adverse effects







14.2 UN proper shipping name ADR/RID: METHANOL IMDG: METHANOL IATA: Methanol

14.3 Transport hazard class(es) ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)










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1.1 Product identifiers Product name : Ethanol

Product Number : 24102 Brand : Sigma-Aldrich Index-No. : 603-002-00-5 REACH No. : 01-2119457610-43-XXXX

CAS-No. : 64-17-5









Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Eye irritation (Category 2), H319


2.2 Label elements


Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

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P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none



3.1 Substances Synonyms : Ethyl alcohol

Formula : C2H6O




Ethanol


64-17-5 200-578-6 603-002-00-5

Flam. Liq. 2; Eye Irrit. 2; H225, H319

<= 100 %











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6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.







hygroscopic Storage class (TRGS 510): Flammable liquids






Health effect Value

Workers Inhalation Long-term systemic effects 950 mg/m3

Workers Skin contact Long-term systemic effects 343mg/kg BW/d

Workers Ingestion Long-term systemic effects 343mg/kg BW/d

Workers Inhalation Acute local effects 1900 mg/m3

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Compartment Value

Soil 0.63 mg/kg


Fresh water 0.96 mg/l

Fresh water sediment 3.6 mg/l

Sewage treatment plant 580 mg/l





Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.2 mm Break through time: 38 min Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.



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a) Appearance Form: liquid, clear Colour: colourless







78 °C





Upper explosion limit: 19 %(V) Lower explosion limit: 3.3 %(V)

k) Vapour pressure 44.6 mmHg at 20.0 °C



n) Water solubility completely soluble


log Pow: -0.35 at 24 °C


363.0 °C


No data available










10.5 Incompatible materials Alkali metals, Oxidizing agents, Peroxides

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10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 10,470 mg/kg(Ethanol) LC50 Inhalation - Rat - 4 h - 30,000 mg/l(Ethanol) LD50 Dermal - Rabbit - 15,800 mg/kg(Ethanol)

Skin corrosion/irritation Skin - Rabbit(Ethanol) Result: No skin irritation - 24 h (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Ethanol) Result: Moderate eye irritation (OECD Test Guideline 405)

Respiratory or skin sensitisation No data available(Ethanol)

Germ cell mutagenicity No data available(Ethanol)

Carcinogenicity



Specific target organ toxicity - single exposure No data available(Ethanol)


Aspiration hazard No data available(Ethanol)

Additional Information RTECS: KQ6300000 Central nervous system depression, narcosis, Damage to the heart., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Ethanol)


12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 14,200 mg/l - 96 h(Ethanol) Toxicity to daphnia and other aquatic invertebrates

LC50 - Ceriodaphnia dubia (water flea) - 5,012 mg/l - 48 h(Ethanol)

NOEC - Daphnia magna (Water flea) - 9.6 mg/l - 9 d(Ethanol) Toxicity to algae EC50 - Chlorella vulgaris (Fresh water algae) - 275 mg/l - 72 h(Ethanol)


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12.2 Persistence and degradability Biodegradability Result: 95 % - Readily biodegradable

12.3 Bioaccumulative potential Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.

12.4 Mobility in soil No data available(Ethanol)









14.2 UN proper shipping name ADR/RID: ETHANOL IMDG: ETHANOL IATA: Ethanol










H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation.

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Page 219 of 485






1.1 Product identifiers Product name : L-(+)-Tartaric acid

Product Number : 251380 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 87-69-4









Classification according to Regulation (EC) No 1272/2008 Serious eye damage (Category 1), H318


2.2 Label elements


Signal word Danger Hazard statement(s) H318 Causes serious eye damage. Precautionary statement(s) P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard none

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Statements



3.1 Substances Synonyms : (2R,3R)-(+)-Tartaric acid

L-Threaric acid

Formula : C4H6O6



(+)-Tartaric acid

CAS-No. EC-No.

87-69-4 201-766-0

Eye Dam. 1; H318 <= 100 %
















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6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.





7.1 Precautions for safe handling Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids








Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact

Page 222 of 485


Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.





a) Appearance Form: crystalline Colour: white



d) pH 1.0 - 2 at 150 g/l at 25 °C




No data available





No data available

k) Vapour pressure No data available



n) Water solubility 150 g/l at 20 °C - completely soluble


log Pow: -1.909 at 20 °C


No data available

q) Decomposition No data available

Page 223 of 485


temperature











10.5 Incompatible materials Bases, Oxidizing agents, Reducing agents




Acute toxicity LC50 Oral - Rat - > 2,000 mg/kg((+)-Tartaric acid) (OECD Test Guideline 423) LC50 Dermal - Rat - > 2,000 mg/kg((+)-Tartaric acid) (OECD Test Guideline 402) LD50 Intravenous - Mouse - 485 mg/kg((+)-Tartaric acid) Remarks: Behavioral:Convulsions or effect on seizure threshold. Blood: Hemorrhage.

Skin corrosion/irritation Skin - Rabbit((+)-Tartaric acid) Result: No skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - In vitro study((+)-Tartaric acid) Result: Risk of serious damage to eyes. (OECD Test Guideline 437)

Respiratory or skin sensitisation in vivo assay((+)-Tartaric acid) Result: Does not cause skin sensitisation. (OECD Test Guideline 429)

Germ cell mutagenicity No data available((+)-Tartaric acid)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

Page 224 of 485


probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available((+)-Tartaric acid)

Specific target organ toxicity - single exposure No data available((+)-Tartaric acid)


Aspiration hazard No data available((+)-Tartaric acid)

Additional Information RTECS: WW7875000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.((+)-Tartaric acid)


12.1 Toxicity No data available Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 93.31 mg/l - 48 h((+)-Tartaric acid) (OECD Test Guideline 202)

Toxicity to algae EC50 - Algae - 51.4 mg/l - 72 h((+)-Tartaric acid)


12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d((+)-Tartaric acid)

Result: 85 % - Readily biodegradable (OECD Test Guideline 306)


12.4 Mobility in soil No data available((+)-Tartaric acid)


12.6 Other adverse effects Harmful to aquatic life. No data available





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H318 Causes serious eye damage.


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Material Safety Data SheetSodium bicarbonate MSDS


Product Name: Sodium bicarbonate

Catalog Codes: SLS3241, SLS2446, SLS3868

CAS#: 144-55-8

RTECS: VZ0950000

TSCA: TSCA 8(b) inventory: Sodium bicarbonate

CI#: Not available.

Synonym: Baking Soda; Bicarbonate of soda; Sodiumacid carbonate; Monosodium carbonate; Sodium hydrogencarbonate; Carbonic acid monosodium salt

Chemical Name: Sodium Bicarbonate

Chemical Formula: NaHCO3









Composition:


Sodium bicarbonate 144-55-8 100

Toxicological Data on Ingredients: Not applicable.


Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, ofinhalation.



Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention if irritation occurs.

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p. 2
















Special Remarks on Fire Hazards: When heated to decomposition it emits acrid smoke and irritating fumes.






Precautions:Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keepaway from incompatibles such as acids.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.


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p. 3


Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.





Odor: Odorless.

Taste: Saline. Alkaline.


Color: White.



Melting Point: Not available.










Solubility:Soluble in cold water. Slightly soluble in alcohol. Solubility in Water: 6.4, 7.6, 8.7, 10.0, 11.3, 12.7, 14.2, 16.5, 19.1 g/100solution at 0, 10, 20, 30, 40, 50, 60, 80, adn 100 deg. C, respectively. Solubility in Water: 6.9, 8,2, 9.6, 11.1, 12.7, 14.5, 16.5,19.7, and 23.6 g/100g water at 0, 10, 20, 30, 40, 50, 60, 80, 100 deg. C, respectively.




Conditions of Instability: Incompatible materials, Moisture. Stable in dry air, but slowly decomposes in moist air.

Incompatibility with various substances: Reactive with acids.

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p. 4


Special Remarks on Reactivity:Reacts with acids to form carbon dioxide. Dangerous reaction with monoammonium phosphate or a sodium-potassium alloy.





Toxicity to Animals: Acute oral toxicity (LD50): 3360 mg/kg [Mouse].


Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.


Special Remarks on Chronic Effects on Humans:Sodium Bicarbonate as produced genetic effects in rats (unscheduled DNA synthesis). However, no affects have been foundin humans.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause mild skin irritation. Eyes: May cause mild eye irritation. Inhalation: Maycause respiratory tract irritation. Symptoms may include coughing and sneezing. Ingestion: Symptoms of overexposure toSodium Bicarbonate include thirst, abdominal pain, gastroenteritis, and inflammation of the digestive tract. Chronic PotentialHealth Effects: Skin: Repeated or prolonged skin contact may cause irritation, drying or cracking of the skin. Ingestion andInhalation: Chronic toxicity usually occurs within 4 to 10 days following ingestion of very large amounts. Repeated or prolongedingestion or inhalation of large amounts may cause metabolic abnormalities, and sodium retention. Metabolic abnormalitiessuch as acidosis, hypernatremia, hypochloremia, alkalosis, hypocalcemia, or sodium retention may affect the blood, kidneys,respiration (cyanosis, apnea secondary to metabolic acidosis or pulmonary edema), and cardiovascular system (tachycardia,hypotension). Severe toxicity may also affect behavior/central nervous system/nervous system. Neurological changes mayresult from metabolic abnormalities. These may include fatigue, irritability, dizziness, mental confusion, paresthesia, seizures,tetany, cerebral edema Medical Conditions Aggravated by Exposure: Persons with pre-existing skin conditions might haveincreased sensitivity. Predisposing conditions that contribute to a mild alkali syndrome include, renal disease, dehydration, adnelectrolyte imbalance, hypertension, sarcoidosis, congestive heart failure, edema, or other sodium retaining conditions.










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p. 5





Federal and State Regulations: TSCA 8(b) inventory: Sodium bicarbonate

Other Regulations: Not available.


WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):This product is not classified according to the EU regulations. Not applicable.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 0

Reactivity: 0



Health: 1

Flammability: 0

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.




Created: 10/10/2005 08:26 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetSodium sulfate anhydrous MSDS


Product Name: Sodium sulfate anhydrous


CAS#: 7757-82-6

RTECS: WE1650000

TSCA: TSCA 8(b) inventory: Sodium sulfate anhydrous

CI#: Not available.

Synonym:

Chemical Name: Sodium Sulfate Anhydrous

Chemical Formula: Na2SO4









Composition:


Sodium sulfate anhydrous 7757-82-6 100

Toxicological Data on Ingredients: Sodium sulfate anhydrous: ORAL (LD50): Acute: 5989 mg/kg [Mouse].


Potential Acute Health Effects:Hazardous in case of eye contact (irritant). Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.




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p. 2

















Special Remarks on Explosion Hazards: At a temperature of 800 C, sodium sulfate and aluminum will explode.





Precautions:Do not ingest. Do not breathe dust. Avoid contact with eyes. Wear suitable protective clothing. If ingested, seek medical adviceimmediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, metals.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Hygroscopic


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p. 3






Physical state and appearance:Solid. (Crystals solid. Crystalline powder. Granular solid. Powdered solid.)

Odor: Odorless.

Taste: Bitter. Saline.


Color: White.


Boiling Point: 1100°C (2012°F)











Solubility:Soluble in cold water, hydrogen iodide, and glycerol.. Insoluble in alcohol.




Conditions of Instability: Excess dust generation, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, metals.

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p. 4


Special Remarks on Reactivity:Hygroscopic. Sodium sulfate reacts violently with magnesium. Also incompatible with aluminum, potassium, mercury, lead,calcium, silver, barium, ammonium ions, and strontium. Sulfates give precipitates with salts of lead, barium, strontium, andcalcium. Silver and mercury form slightly soluble salts. Alcohol preciptates most sulfates out of solution.

Special Remarks on Corrosivity:The rates of corrosion of iron and steel in water are a function of the specific mineral quality as well as the alkalinity and pHvalues. Sodium sulfate ... is a strong contributor to the rate of corrosion. For example, in water with 400 mg/l of alkalinity (asCaCO3) at pH 7, the corrosion rate will be zero at 200 mg/l of Na2SO4, but when the concentration of sodium sulfate is 400mg/l, the corrosion rate will be about 100 mg per square cm per day.




Toxicity to Animals: Acute oral toxicity (LD50): 5989 mg/kg [Mouse].


Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.


Special Remarks on Chronic Effects on Humans:May cause adverse reproductive effects (fetotoxicity) based on animal studies. Human human data found May cause cancer(tumorigenic) based on animal studies. No human data found. Placental absorption of sulfate ion has been characterized.Sulfate ion levels at term are somewhat higher in fetal than in maternal blood.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause irritation, although it is not known to be an irritant. Eyes: May cause eyeirritation. Ingestion: Saline cathartics (laxitives) are poorly absorbed from the gastrointestinal tract; hence, systemic toxicityis unlikely unless massive amounts have been ingested. Ingestion of large amounts may cause gastrointestinal (digestive)tract irritation with abdominal pain, nausea, vomiting, diarrhea. Low hazard for usual industrial handling. Inhalation: May causerespiratory tract irritation. Low hazard for usual industrial handling.










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p. 5





Federal and State Regulations:Pennsylvania RTK: Sodium sulfate anhydrous Massachusetts RTK: Sodium sulfate anhydrous TSCA 8(b) inventory: Sodiumsulfate anhydrous

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.



DSCL (EEC):R36- Irritating to eyes. S36- Wear suitable protective clothing. S46- If swallowed, seek medical advice immediately and showthis container or label.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 0

Reactivity: 0



Health: 2

Flammability: 0

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.




Created: 10/10/2005 08:28 PM

Last Updated: 05/21/2013 12:00 PM


Page 236 of 485

Accela ChemBio Inc. 9883 Pacific Heights Blvd., Suite H, San Diego, CA 92121Tel: (858) 699-3322 Fax: (858) 876-1948 (US Customers only), (858) 769-6322 (Other Customers)

[email protected] (US Customers only), [email protected] (Other Customers) www.accelachem.com

SAFETY DATA SHEET2015-09-21

1. Identification of substance * Product name: N-(4-Cyanophenyl)glycine* Chemical ID: SY021403* Manufacturer/Supplier:

Accela ChemBio Inc. 9883 Pacific Heights Blvd, Suite H, San Diego CA 92121, USA; 222 Guangdan Road, No. 21, Pudong New Area, Shanghai, 201318, China; Emergency Phone: (858) 699 3322, +86 (21) 5079 5510

* Information Department: Health, Safety and Environmental Department * Emergency information: During normal hours the Health, Safety and Environmental Department. After

normal hours call Chemtrec at (800) 424-9300.2. Hazards identification * According to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

* Pictogram: * Signal word: Warning

* Hazard statement(s): H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled.H315 Causes skin irritation.H319 Causes serious eye irritation.

* Precautionary statement(s): P261 Avoid breathing dust/fume/gas/mist/vapours/spray.P264 Wash hands thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P271 Use only outdoors or in a well-ventilated area.P280 Wear protective gloves/protective clothing/eye protection/face protection.P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact

lenses, if present and easy to do. Continue rinsing.P312 Call a POISON CENTER or doctor/physician if you feel unwell.P332+P313 IF SKIN irritation occurs: Get medical advice/attention.P501 Dispose of contents/container to..…

* Supplemental Hazard: no data known* According to EU Directives 67/548/EEC or 1999/45/EC

* Hazard symbols: No data known * Risk phrases: No data known

* Safety phrases: No data known* Other Hazards

no data known.3. Composition/information on ingredients

* Chemical characterization-Description(CAS#): N-(4-Cyanophenyl)glycine (CAS# 42288-26-6 ); ≥ 97%4. First aid measures * Description of first aid measures

* General information Immediately remove any clothing soiled by the product.

* After inhalation Supply fresh air. If required, provide artificial respiration. Keep patient warm. Seek immediate medical advice.

* After skin contact Immediately wash with water and soap and rinse thoroughly. Seek immediate medical advice.

* After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.

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http://www.accelachem.com



* After swallowing Seek immediate medical advice.

* Most important symptoms and effects, both acute and delayed no data available

* Indication of any immediate medical attention and special treatment needed no data available

5. Fire fighting measures * Extinguishing media * Suitable extinguishing agents

CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.

* Special hazards arising from the substance or mixture Carbon monoxide and carbon dioxide, Nitrogen oxides (NOx), .

* Advice for firefightersProtective equipment: Wear self-contained respirator. Wear fully protective impervious suit.

6. Accidental release measures* Personal precautions, protective equipment and emergency procedures

Wear protective equipment. Keep unprotected persons away. Ensure adequate ventilation. * Environmental precautions

Do not allow material to be released to the environment without proper governmental permits. * Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.* Reference to other sections

See Section 7 for information on safe handling See Section 8 for information on personal protection equipment. See Section 13 for disposal information.

7. Handling and storage * Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. Ensure good ventilation at the workplace.

* Conditions for safe storage, including any incompatibilities Keep container tightly sealed. Store in a dry, cool and well-ventilated place.Light sensitive

* Specific end use(s) no data available8. Exposure controls/personal protection

* Additional information about design of technical systems: Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.

* Control parameters* Components with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.

* Additional information: no data known* Exposure controls * Personal protective equipment * General protective and hygienic measures

The usual precautionary measures for handling chemicals should be followed. Keep away from foodstuffs, beverages and feed. Remove all soiled and contaminated clothing immediately. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin.

* Breathing equipment: Use suitable respirator when high concentrations are present.

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* Protection of hands: Impervious gloves * Eye protection: Safety glasses * Body protection: Protective work clothing.

9. Physical and chemical properties * Information on basic physical and chemical properties

* Form: Solid* Color: White to yellow* Odor: Not determined* Melting point/Melting range(°C): Not determined

* Boiling point/Boiling range(°C): Not determined* Sublimation temperature/start: Not determined * Flash point: Not determined * Ignition temperature: Not determined * Decomposition temperature: Not determined * Danger of explosion: Not determined* Explosion limits: Not determined * Vapor pressure: Not determined * Density: Not determined

* Other safety information no data available

10. Stability and reactivity * Reactivity

no data known* Chemical stability

Stable under proper conditions* Possibility of hazardous reactions: No dangerous reactions known.

* Conditions to avoid: no data known* Incompatible materials: Oxidizing agents* Hazardous decomposition products

Other decomposition products - no data known11. Toxicological information

* Information on toxicological effects* Acute toxicity: no data known* Primary irritant effect:

* on the skin: maybe irritant to skin* on the eye: maybe irritating effect * Sensitization: No sensitizing effects known. * Subacute to chronic toxicity:

Other than potential irritation (see above), no information on illness or injury to humans from acute or chronic exposure to this product is available.

* Additional toxicological information: To the best of our knowledge the acute and chronic toxicity of this substance is not fully known. No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH.

12. Ecological information: * Toxicity: no data known* Persistence and degradability: no data known* Bioaccumulative potential: no data known* Mobility in soil: no data known* Results of PBT and vPvB assessment:

no data known * Other adverse effects: no data known

13. Disposal considerations * Waste treatment methods

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* Product Recommendation Consult state, local or national regulations to ensure proper disposal.

* Uncleaned packagings Recommendation: Disposal must be made according to official regulations.

14. Transport information * UN number

DOT, ADR, IMDG, IATA: No data known* UN proper shipping name

DOT, ADR, IMDG, IATA: No data known* Transport hazard class(es)

DOT, ADR, IMDG, IATA Class: No data known* Packaging group

DOT, ADR, IMDG, IATA: No data known* Environmental hazards: no data known* Special precautions for user: no data known

15. Regulatory information* Safety, health and environmental regulations/legislation specific for the substance or mixture

Adhere to all Federal, State and local regulations. Information about limitation of use: Use of this product is restricted to research and development only by technically qualified individuals.

* Chemical Safety Assessment For this product a chemical safety assessment was not carried out

16. Other information: Employers should use this information only as a supplement to other information gathered by them,

and should make independent judgement of suitability of this information to ensure proper use and protect the health and safety of employees. This information is furnished without warranty, and any use of the product not in conformance with this Material Safety Data Sheet, or in combination with any other product or process, is the responsibility of the user.

* Department issuing MSDS: Health, Safety and Environmental Department. * Contact: Darrell R. Sanders

Notice to ReaderAccela ChemBio supplied chemicals are for research purposes only and are NOT intended for use as

drug, food additives, households, or pesticides. The information herein is believed to be correct, but does not claim to be all inclusive and should be used only as a guide. Neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All chemical reagents must be handled with the recognition that their chemical, physiological, toxicological, and hazardous properties have not been fully investigated or determined. All chemical reagents should be handled only by individuals who are familiar with their potential hazards and have been fully trained in proper safety, laboratory, and chemical handling procedures. Although certain hazards are described herein, we can not guarantee that these are the only hazards which exist. Our MSDS sheets are based only on data available at the time of shipping and are subject to change without notice as new information is obtained. Avoid long storage periods since the product is subject to degradation which age and may become more dangerous or hazardous. It is the responsibility of the user to request updated MSDS sheets for products that are stored for extended periods. Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment (e.g. protective goggles and clothing, breathing equipment, facial mask, fume hood). For proper handling and disposal, always comply with federal, state, and local regulations.

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1.1 Product identifiers Product name : CDI



CAS-No. : 530-62-1









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Skin corrosion (Category 1B), H314


2.2 Label elements


Signal word Danger Hazard statement(s) H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. Precautionary statement(s) P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection.

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P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor. Supplemental Hazard Statements

none



3.1 Substances Synonyms : CDI

Formula : C7H6N4O



1,1'-Carbonylbis-1H-imidazole

CAS-No. EC-No.

530-62-1 208-488-9

Acute Tox. 4; Skin Corr. 1B; H302, H314

<= 100 %














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Handle and store under inert gas. Hydrolyses readily. Storage class (TRGS 510): Non-combustible, corrosive hazardous materials








Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact

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Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.





a) Appearance Form: solid Colour: beige



d) pH 7.7 at 50 g/l




No data available

g) Flash point No data available




No data available






No data available

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No data available


No data available







10.2 Chemical stability May decompose on exposure to moist air or water. Stable under recommended storage conditions.


10.4 Conditions to avoid Exposure to moisture

10.5 Incompatible materials Strong acids, Strong oxidizing agents, Strong bases, Amines

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 1,071 mg/kg(1,1'-Carbonylbis-1H-imidazole)

Skin corrosion/irritation Skin - Rabbit(1,1'-Carbonylbis-1H-imidazole) Result: Corrosive

Serious eye damage/eye irritation Eyes - Rabbit(1,1'-Carbonylbis-1H-imidazole) Result: Severe eye irritation

Respiratory or skin sensitisation No data available(1,1'-Carbonylbis-1H-imidazole)

Germ cell mutagenicity No data available(1,1'-Carbonylbis-1H-imidazole)

Carcinogenicity


Reproductive toxicity No data available(1,1'-Carbonylbis-1H-imidazole)

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Specific target organ toxicity - single exposure No data available(1,1'-Carbonylbis-1H-imidazole)


Aspiration hazard No data available(1,1'-Carbonylbis-1H-imidazole)

Additional Information RTECS: Not available


12.1 Toxicity Toxicity to fish LC0 - Leuciscus idus (Golden orfe) - 250 mg/l - 48 h(1,1'-Carbonylbis-1H-

imidazole) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia (water flea) - 341.5 mg/l - 48 h(1,1'-Carbonylbis-1H-imidazole)



12.4 Mobility in soil No data available(1,1'-Carbonylbis-1H-imidazole)









14.2 UN proper shipping name ADR/RID: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (1,1'-Carbonylbis-1H-imidazole) IMDG: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (1,1'-Carbonylbis-1H-imidazole) IATA: Corrosive solid, basic, organic, n.o.s. (1,1'-Carbonylbis-1H-imidazole)


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H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage.


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Material Safety Data SheetAcetic acid MSDS


Product Name: Acetic acid

Catalog Codes: SLA3784, SLA1438, SLA2101, SLA3604,SLA1258

CAS#: 64-19-7

RTECS: AF1225000

TSCA: TSCA 8(b) inventory: Acetic acid


Synonym: Acetic acid; glacial acetic acid

Chemical Name: Acetic Acid, Glacial










Composition:


Acetic acid 64-19-7 100

Toxicological Data on Ingredients: Acetic acid: ORAL (LD50): Acute: 3310 mg/kg [Rat]. 4960 mg/kg [Mouse]. 3530 mg/kg[Rat]. DERMAL (LD50): Acute: 1060 mg/kg [Rabbit]. VAPOR (LC50): Acute: 5620 ppm 1 hours [Mouse].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skincontact (corrosive, permeator), of eye contact (corrosive). Liquid or spray mist may produce tissue damage particularly onmucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist mayproduce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of theeye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.

Potential Chronic Health Effects:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, mucousmembranes, skin, teeth. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated

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or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolongedexposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.












Flash Points: CLOSED CUP: 39°C (102.2°F). OPEN CUP: 43°C (109.4°F).

Flammable Limits: LOWER: 4% UPPER: 19.9%


Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizingmaterials, of metals.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive in presence of oxidizing materials.


Special Remarks on Fire Hazards:Reacts with metals to produces flammable hydrogen gas. It will ignite on contact with potassium-tert-butoxide. A mixture ofammonium nitrate and acetic acid ignites when warmed, especially if warmed.

Special Remarks on Explosion Hazards:

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Acetic acid vapors may form explosive mixtures with air. Reactions between acetic acid and the following materialsare potentially explosive: 5-azidotetrazole, bromine pentafluoride, chromium trioxide, hydrogen peroxide, potassiumpermanganate, sodium peroxide, and phorphorus trichloride. Dilute acetic acid and dilute hydrogen can undergo anexothermic reaction if heated, forming peracetic acid which is explosive at 110 degrees C. Reaction between chlorinetrifluoride and acetic acid is very violent, sometimes explosive.


Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of sodium carbonate.

Large Spill:Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. If theproduct is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is inits liquid form: Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Absorbwith an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use waterspray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistanceon disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at aconcentration level above TLV. Check TLV on the MSDS and with local authorities.


Precautions:\Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis.




Personal Protection:Splash goggles. Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves(impervious).


Exposure Limits:TWA: 10 STEL: 15 (ppm) [Australia] TWA: 25 STEL: 27 (mg/m3) [Australia] TWA: 10 STEL: 15 (ppm) from NIOSH TWA: 25STEL: 37 (mg/m3) from NIOSH TWA: 10 STEL: 15 (ppm) [Canada] TWA: 26 STEL: 39 (mg/m3) [Canada] TWA: 25 STEL: 37(mg/m3) TWA: 10 STEL: 15 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 10 (ppm) from OSHA (PEL) [United States]TWA: 25 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits.


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Odor: Pungent, vinegar-like, sour (Strong.)

Taste: Vinegar, sour (Strong.)


Color: Colorless. Clear (Light.)

pH (1% soln/water): 2 [Acidic.]



Critical Temperature: 321.67°C (611°F)






Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2



Solubility:Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible with Glycerol, alcohol, Benzene, CarbonTetrachloride. Practically insoluble in Carbon Disulfide.




Conditions of Instability: Heat, ignition sources, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, metals, acids, alkalis.

Corrosivity:Highly corrosive in presence of stainless steel(304). Slightly corrosive in presence of aluminum, of copper. Non-corrosive inpresence of stainless steel(316).

Special Remarks on Reactivity:Reacts violently with strong oxidizing agents, acetaldehyde, and acetic anhydride. Material can react with metals, strongbases, amines, carbonates, hydroxides, phosphates, many oxides,cyanides, sulfides, chromic acid, nitric acid, hydrogenperoxide, carbonates. ammonium nitrate, ammonium thiosulfate, chlorine trifluoride, chlorosulfonic acid, perchloric acid,permanganates, xylene, oleum, potassium hydroxide, sodium hydroxide, phosphorus isocyanate, ethylenediamine, ethyleneimine.

Special Remarks on Corrosivity: Moderate corrosive effect on bronze. No corrosion data on brass




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Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3310 mg/kg [Rat]. Acute dermal toxicity (LD50): 1060 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 56201 hours [Mouse].

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage tothe following organs: kidneys, mucous membranes, skin, teeth.

Other Toxic Effects on Humans:Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (irritant), of ingestion, .Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive).


Special Remarks on Chronic Effects on Humans: May affect genetic material and may cause reproductive effects based onanimal data. No human data found.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Extremely irritating and corrosive. Causes skin irritation (reddening and itching,inflammation). May cause blistering , tissue damage and burns. Eyes: Extremely irritating and corrosive. Causes eye irritation,lacrimation, redness, and pain. May cause burns, blurred vision, conjunctivitis, conjunctival and corneal destruction andpermanent injury. Inhalation: Causes severe respiratory tract irritation. Affects the sense organs (nose, ear, eye, taste),and blood. May cause chemical pneumonitis, bronchitis, and pulmonary edema. Severe exposure may result in lung tissuedamage and corrosion (ulceration) of the mucous membranes. Inhalation may also cause rhinitis, sneezing, coughing,oppressive feeling in the chest or chest pain, dyspnea, wheezing, tachypnea, cyanosis, salivation, nausea, giddiness,muscular weakness. Ingestion: Moderately toxic. Corrosive. Causes gastrointestinal tract irritation (burning and pain of themouth, throat, and abdomen, coughing, ulceration, bleeding, nausea, abdomial spasms, vomiting, hematemesis, diarrhea.May Also affect the liver (impaired liver function), behavior (convulsions, giddines, muscular weakness), and the urinarysystem - kidneys (Hematuria, Albuminuria, Nephrosis, acute renal failure, acute tubular necrosis). May also cause dyspneaor asphyxia. May also lead to shock, coma and death. Chronic Potential Health Effects: Chronic exposure via ingestion maycause blackening or erosion of the teeth and jaw necrosis, pharyngitis, and gastritis. It may also behavior (similar to acuteingestion), and metabolism (weight loss). Chronic exposure via inhalation may cause asthma and/or bronchitis with cough,phlegm, and/or shortness of breath . It may also affect the blood (decreased leukocyte count), and urinary system (kidneys).Repeated or prolonged skin contact may cause thickening, blackening, and cracking of the skin.


Ecotoxicity:Ecotoxicity in water (LC50): 423 mg/l 24 hours [Fish (Goldfish)]. 88 ppm 96 hours [Fish (fathead minnow)]. 75 ppm 96 hours[Fish (bluegill sunfish)]. >100 ppm 96 hours [Daphnia].

BOD5 and COD: BOD-5: 0.34-0.88 g oxygen/g







DOT Classification:

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CLASS 3: Flammable liquid. Class 8: Corrosive material

Identification: : Acetic Acid, Glacial UNNA: 2789 PG: II



Federal and State Regulations:New York release reporting list: Acetic acid Rhode Island RTK hazardous substances: Acetic acid Pennsylvania RTK: Aceticacid Florida: Acetic acid Minnesota: Acetic acid Massachusetts RTK: Acetic acid New Jersey: Acetic acid California Director'sList of Hazardous Subtances (8 CCR 339): Acetic acid TSCA 8(b) inventory: Acetic acid CERCLA: Hazardous substances.:Acetic acid: 5000 lbs. (2268 kg)



WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid.

DSCL (EEC):R10- Flammable. R35- Causes severe burns. S23- Do not breathe gas/fumes/vapour/spray [***] S26- In case of contact witheyes, rinse immediately with plenty of water and seek medical advice. S45- In case of accident or if you feel unwell, seekmedical advice immediately (show the label where possible).

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 2

Reactivity: 0

Personal Protection: H


Health: 3

Flammability: 2

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves (impervious). Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wearappropriate respirator when ventilation is inadequate. Splash goggles.




Created: 10/09/2005 03:35 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

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no liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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1.1 Product identifiers Product name : Hexyl chloroformate



CAS-No. : 6092-54-2









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Acute toxicity, Oral (Category 3), H301 Skin corrosion (Category 1B), H314


2.2 Label elements


Signal word Danger Hazard statement(s) H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H314 Causes severe skin burns and eye damage.

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Precautionary statement(s) P261 Avoid breathing vapours. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove


none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Lachrymator.


3.1 Substances Formula : C<SB>7</>H<SB>13</>ClO<SB>2</> Molecular weight : 164.63 g/mol CAS-No. : 6092-54-2 EC-No. : 228-036-4 Hazardous ingredients according to Regulation (EC) No 1272/2008


Hexyl chloroformate

CAS-No. EC-No.

6092-54-2 228-036-4

Acute Tox. 3; Skin Corr. 1B; H331, H311, H301, H314

<= 100 %











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5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas






6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.





Recommended storage temperature 2 - 8 °C

Vent periodically. Handle and open container with care. Moisture sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials






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Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.





a) Appearance Form: liquid Colour: colourless





No data available


60 - 61 °C at 9 hPa - lit.





No data available

k) Vapour pressure 3.102 mmHg at 20 °C 29.986 mmHg at 55 °C





No data available

p) Auto-ignition No data available

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temperature


No data available










10.5 Incompatible materials Strong bases, Bases, Alcohols, Amines

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity No data availableHexyl chloroformate

Skin corrosion/irritation No data available(Hexyl chloroformate)

Serious eye damage/eye irritation No data available(Hexyl chloroformate)

Respiratory or skin sensitisation No data available(Hexyl chloroformate)

Germ cell mutagenicity No data available(Hexyl chloroformate)

Carcinogenicity


Reproductive toxicity No data available(Hexyl chloroformate)

Specific target organ toxicity - single exposure No data available(Hexyl chloroformate)


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Aspiration hazard No data available(Hexyl chloroformate)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea(Hexyl chloroformate)





12.4 Mobility in soil No data available(Hexyl chloroformate)





Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.




14.2 UN proper shipping name ADR/RID: CHLOROFORMATES, TOXIC, CORROSIVE, N.O.S. (Hexyl chloroformate) IMDG: CHLOROFORMATES, TOXIC, CORROSIVE, N.O.S. (Hexyl chloroformate) IATA: Chloroformates, toxic, corrosive, n.o.s. (Hexyl chloroformate)

14.3 Transport hazard class(es) ADR/RID: 6.1 (8) IMDG: 6.1 (8) IATA: 6.1 (8)



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H301 Toxic if swallowed. H301 + H311 + H331

Toxic if swallowed, in contact with skin or if inhaled

H311 Toxic in contact with skin. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled.


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Material Safety Data SheetMethylene chloride MSDS


Product Name: Methylene chloride

Catalog Codes: SLM2398, SLM3772, SLM1297,SLM2677, SLM4054

CAS#: 75-09-2

RTECS: PA8050000

TSCA: TSCA 8(b) inventory: Methylene chloride

CI#: Not available.

Synonym: Dichloromethane

Chemical Name: Methylene Chloride

Chemical Formula: C-H2-Cl2









Composition:


Methylene chloride 75-09-2 100

Toxicological Data on Ingredients: Methylene chloride: ORAL (LD50): Acute: 1600 mg/kg [Rat].


Potential Acute Health Effects: Very hazardous in case of eye contact (irritant), of ingestion, of inhalation. Hazardous in caseof skin contact (irritant, permeator). Inflammation of the eye is characterized by redness, watering, and itching.

Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Classified + (Proven.) by OSHA. Classified 2B (Possiblefor human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTALTOXICITY: Not available. The substance is toxic to lungs, the nervous system, liver, mucous membranes, central nervoussystem (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.


Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for atleast 15 minutes. Cold water may be used. Get medical attention immediately.

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Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient.Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoesbefore reuse. Get medical attention.

Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seekimmediate medical attention.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Getmedical attention if symptoms appear.

Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt orwaistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seekmedical attention.

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing suchas a collar, tie, belt or waistband.






Flammable Limits: LOWER: 12% UPPER: 19%

Products of Combustion: These products are carbon oxides (CO, CO2), halogenated compounds.


Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanicalimpact: Not available. Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog orfoam. Do not use water jet.




Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposalcontainer.

Large Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal. Be careful that theproduct is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


Precautions: Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical adviceimmediately and show the container or the label. Avoid contact with skin and eyes.


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Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations ofvapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator orequivalent. Gloves.

Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self containedbreathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient;consult a specialist BEFORE handling this product.

Exposure Limits: TWA: 50 from ACGIH (TLV) [United States] TWA: 174 from ACGIH (TLV) [United States] Consult localauthorities for acceptable exposure limits.















Odor Threshold: 214 ppm

Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0.1



Solubility: Easily soluble in methanol, diethyl ether, n-octanol, acetone. Partially soluble in cold water.





Incompatibility with various substances: Not available.


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Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUREXPOSURE. Acute oral toxicity (LD50): 1600 mg/kg [Rat]. Acute toxicity of the vapor (LC50): 52000 1 hours [Rat].

Chronic Effects on Humans: CARCINOGENIC EFFECTS: Classified + (Proven.) by OSHA. Classified 2B (Possible forhuman.) by IARC. Causes damage to the following organs: lungs, the nervous system, liver, mucous membranes, centralnervous system (CNS).

Other Toxic Effects on Humans: Very hazardous in case of ingestion, of inhalation. Hazardous in case of skin contact(irritant, permeator).


Special Remarks on Chronic Effects on Humans: Human: passes through the placenta, excreted in maternal milk.





Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long termdegradation products may arise.




Waste Disposal:


DOT Classification: CLASS 6.1: Poisonous material.

Identification: : Dichloromethane UNNA: 1593 PG: III



Federal and State Regulations: California prop. 65: This product contains the following ingredients for which the Stateof California has found to cause cancer, birth defects or other reproductive harm, which would require a warning underthe statute: Methylene chloride California prop. 65: This product contains the following ingredients for which the State ofCalifornia has found to cause cancer which would require a warning under the statute: Methylene chloride Pennsylvania

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RTK: Methylene chloride Massachusetts RTK: Methylene chloride TSCA 8(b) inventory: Methylene chloride SARA 313 toxicchemical notification and release reporting: Methylene chloride CERCLA: Hazardous substances.: Methylene chloride



WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2A: Materialcausing other toxic effects (VERY TOXIC).

DSCL (EEC): R22- Harmful if swallowed. R38- Irritating to skin. R41- Risk of serious damage to eyes. R45- May causecancer.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.Wear appropriate respirator when ventilation is inadequate. Splash goggles.




Created: 10/10/2005 10:43 AM

Last Updated: 05/21/2013 12:00 PM


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NIACET CORPORATION MSDS 400 47th Street Niacet Niagara Falls, NY 14304 Anhydrous HCl Fax (716) 285-1497 Phone (716) 285-1474 Issued April 2013

EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616

MATERIAL SAFETY DATA SHEET Anhydrous HCl

SECTION I – CHEMICAL PRODUCT IDENTIFICATION Product Name: Hydrogen Chloride Product Overview: Anhydrous hydrogen chloride, also referred to as hydrogen chloride gas, is a clear,

colorless gas with an extremely sharp odor. “Anhydrous” means dry or without water. Anhydrous hydrogen chloride is extremely attracted to water and when exposed to air, quickly reacts with the moisture in the air forming fumes, which are a mist of hydrochloric acid. NIACET ® anhydrous hydrogen chloride is sold as liquefied gas. Aqueous hydrochloric acid is a highly corrosive liquid that is formed upon mixing anhydrous hydrogen chloride with water or moisture in the air. It emits a pungent odor and strong fumes in moist air. The color ranges from clear to slightly yellow.

Chemical Synonyms: Hydrochloric Acid; Anhydrous hydrochloric acid; Chlorohydric acid; Hydrochloric acid gas; Hydrochloride; Muriatic acid; HCl; Hydrochloric acid, anhydrous; Hydrogen-chloride-anhydrous-; Acide chlorhydrique; Acido cloridrico; NA 1789; UN 1789; UN 2186; Anhydrous hydrogen chloride; Hydrogen chloride (acid); Marine acid; Soldering acid; Spirits of salts

Emergency Contact: (800) 424-9300; (202) 483-7616 SECTION II – HAZARDS IDENTIFICATION

Physical State Gas. [COLORLESS TO SLIGHTLY YELLOW LIQUEFIED COMPRESSED GAS WITH AN IRRITATING ODOR; OR COLORLESS FUMING GAS WITH A PUNGENT, IRRITATING ODOR]

Emergency Overview DANGER! CAUSES SEVERE RESPIRATORY TRACT, EYE AND SKIN BURNS. HARMFUL IF INHALED. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA. CONTENTS UNDER PRESSURE.

Do not puncture or incinerate container. Do not breathe gas. Do not get on skin or clothing. May cause target organ damage, based on animal data. Use only with adequate ventilation. Keep container closed. Do not get in eyes, on skin or on clothing. Avoid breathing gas. Wash thoroughly after handling.

Contact with rapidly expanding gases can cause frostbite. Target Organs May cause damage to the following organs: lungs, upper respiratory tract, skin,

eyes. Routes of Entry Inhalation Dermal Eyes

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 Potential acute health effects

Eyes Severely corrosive to the eyes. Causes severe burns. Contact with rapidly expanding gas may cause burns or frostbite.

Skin Severely corrosive to the skin. Causes severe burns. Contact with rapidly expanding gas may cause burns or frostbite.

Inhalation Toxic by inhalation. Severely corrosive to the respiratory system. Ingestion Ingestion is not a normal route of exposure for gases

Potential chronic health effects

Target organs May cause damage to the following organs: lungs, upper respiratory tract, skin, eyes.

Medical conditions aggravated by over-

exposure

Pre-existing disorders involving any target organs mentioned in this MSDS as being at risk may be aggravated by over-exposure to this product.

See toxicological information (Section 11) SECTION III – COMPOSITION, INFORMATION ON INGREDIENTS Product Name Name CAS Number % Volume Exposure Limits Hydrogen Chloride 7647-01-0 100 ACGIH TLV (United States, 1/2009) C: 2 ppm NIOSH REL (United States, 6/2009) CEIL: 7 mg/m³ CEIL: 5 ppm OSHA PEL (United States, 11/2006) CEIL: 7 mg/m³ CEIL: 5 ppm SECTION IV – FIRST AID No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

Eye contact Check for and remove any contact lenses. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention immediately.

Skin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention immediately.

Frostbite Try to warm up the frozen tissues and seek medical attention.

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616

Inhalation Move exposed person to fresh air. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately.

Ingestion As this product is a gas, refer to the inhalation section. SECTION V – FIRE-FIGHTING

Flammability of the Product

Non-flammable

Products of Combustion Decomposition products may include the following materials: halogenated compounds

Fire-fighting Media and Instructions

Use an extinguishing agent suitable for the surrounding fire. Apply water from a safe distance to cool container and protect surrounding area. If involved in fire, shut off flow immediately if it can be done without risk. Contains gas under pressure. In a fire or if heated, a pressure increase will occur and the container may burst or explode.

Special Protective Equipment for Fire-

Fighters

Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

SECTION VI – ACCIDENTAL RELEASE

Personal Precautions

Immediately contact emergency personnel. Keep unnecessary personnel away. Use suitable protective equipment (section 8). Shut off gas supply if this can be done safely. Isolate area until gas has dispersed.

Environmental Precautions

Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers.

Methods for Clean-up

Immediately contact emergency personnel. Stop leak if without risk. Note: see Section I for emergency contact information and section XIII for information on waste disposal.

SECTION VII – HANDLING AND STORAGE Handling Use only with adequate ventilation. Wash thoroughly after handling. High pressure

gas. Do not puncture or incinerate container. Use equipment rated for cylinder pressure. Close valve after each use and when empty. Do not get in eyes, on skin or on clothing. Keep container closed. Do not get on skin or clothing. Protect cylinders from physical damage; do not drag, roll, slide, or drop. Use a suitable hand truck for cylinder movement.

Storage Cylinders should be stored upright, with valve protection cap in place, and firmly secured to prevent falling or being knocked over. Cylinder temperatures should not exceed 52 °C (125 °F).

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION VIII – EXPOSURE CONTOL/PERSONAL PROTECTION Engineering Controls Use only with adequate ventilation. Use process enclosures, local exhaust

ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.

Personal Protection

Eyes Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists or dusts.

Skin Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

Respiratory Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. The applicable standards are (US) 29 CFR 1910.134 and (Canada) Z94.4-93

Hands Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary.

Personal Protection for Large Spill

Self-contained breathing apparatus (SCBA) should be used to avoid inhalation of the product. Full chemical-resistant suit and self-contained breathing apparatus should be worn only by trained and authorized persons.

Product Name Name CAS Number % Volume Exposure Limits Hydrogen Chloride 7647-01-0 100 ACGIH TLV (United States, 1/2009) C: 2 ppm NIOSH REL (United States, 6/2009) CEIL: 7 mg/m³ CEIL: 5 ppm OSHA PEL (United States, 11/2006) CEIL: 7 mg/m³ CEIL: 5 ppm

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION IX – PHYSICAL DATA

Molecular weight: 36.46 g/mole Molecular formula: Cl-H

Boiling/condensation point: -85°C (-121°F) Melting/freezing point: -113.9°C (-173°F)

Critical temperature: 51.5°C (124.7°F) Vapor pressure: 613 (psig)

Vapor density: 1.3 (Air = 1) Specific Volume (ft3/lb): 10.5263

Gas Density (lb/ft3): 0.095 SECTION X – STABILITY AND REACTIVITY

Stability and Reactivity The product is stable. Incompatibility with

various substances Extremely reactive or incompatible with the following materials: Alkalis Moisture Highly reactive or incompatible with the following materials: Metals

Hazardous Decomposition Products

Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Hazardous Polymerization

Under normal conditions of storage and use, hazardous polymerization will not occur.

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION XI – TOXICOLOGICAL INFORMATION Product/Ingredient Name Result Species Dose Exposure

Hydrogen Chloride LC50 Inhalation Gas Rat 3124 ppm 1 hour LC50 Inhalation Gas Mouse 1108 ppm 1 hour

IDLH 50ppm Chronic Effects on

Humans CARCINOGENIC EFFECTS: A4 (Not classifiable for humans or animals.) by ACGIH, 3 (Not classifiable for humans.) by IARC. May cause damage to the following organs: lungs, upper respiratory tract, skin, eyes.

Other Toxic Effects on Humans

Extremely hazardous by the following route of exposure: of skin contact (corrosive), of eye contact (corrosive), of inhalation (lung corrosive).

Specific Effects

Carcinogenic Effects No known significant effect or critical hazards Mutagenic Effects No known significant effect or critical hazards

Reproduction Toxicity No known significant effect or critical hazards SECTION XII – ECOLOGICAL INFORMATION Aquatic ecotoxicity Product/Ingredient Name Test Result Species Exposure Hydrogen Chloride - Acute LC50 282000 ug/L Fresh water Fish 96 Hours - Acute LC50 260000 ug/L Marine water Crustaceans 48 hours - Acute LC50 240000 ug/L Marine water Crustaceans 48 hours Products of Degradation

Environmental Fate Not available Environmental Hazards No known significant effects or critical hazards Toxicity to Environment Not available

SECTION XIII – DISPOSAL Product removed from the cylinder must be disposed of in accordance with appropriate Federal, State, local regulation. Return cylinders with residual product to Niacet Corporation. Do not dispose of locally.

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION XIV – TRANSPORTATION

Regulatory Information UN Number

Proper Shipping

Name Class Packing

Group Label Additional Information

DOT Classification UN1050

Hydrogen Chloride,

Anhydrous 2.3

Not Applicable

(Gas)

Reportable quantity: 5000 lbs. (2270 kg)

Limited quantity: Yes

Packaging instruction

Passenger aircraft Quantity limitation:

Forbidden

Cargo aircraft Quantity limitation:

Forbidden

Special Provisions: 3

TDG Classification UN1050

Hydrogen Chloride,

Anhydrous 2.3

Not Applicable

(Gas)

Explosive Limit

and Limited Quantity Index: 0

ERAP Index: 25

Passenger Carrying Ship Index: Forbidden

Passenger Carrying Road or Rail Index:

Forbidden

Special provisions: 38

Mexico Classification UN1050

Hydrogen Chloride,

Anhydrous 2.3

Not Applicable

(Gas)

None

Refer to CFR 49 (or authority having jurisdiction) to determine the information required for shipment of the product.

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION XV – REGULATORY INFORMATION United States

U.S. Federal Regulation United States inventory (TSCA 8b): This material is listed or exempted. SARA 302/304/311/312 extremely hazardous substances: Hydrogen chloride SARA 302/304 emergency planning and notification: Hydrogen chloride SARA 302/304/311/312 hazardous chemicals: Hydrogen chloride SARA 311/312 MSDS distribution - chemical inventory - hazard identification: Hydrogen chloride: Sudden release of pressure, Immediate (acute) health hazard, Delayed (chronic) health hazard Clean Water Act (CWA) 311: Hydrogen chloride Clean Air Act (CAA) 112 regulated flammable substances: Hydrogen chloride Clean Air Act (CAA) 112 regulated toxic substances: Hydrogen chloride

SARA 313 Product Name CAS Number Concentration

From R – Reporting Requirements

Hydrogen Chloride 7647-01-0 100

Supplier Notification Hydrogen Chloride 7647-01-0 100 SARA 313 notifications must not be detached from the MSDS and any copying and redistribution of the MSDS shall include copying and redistribution of the notice attached to copies of the MSDS subsequently redistributed.

State Regulations Massachusetts Substances: This material is listed. New Jersey Hazardous Substances: This material is listed. New Jersey Toxic Catastrophe Prevention Act: This material is listed. New York Acutely Hazardous Substances: This material is listed. Pennsylvania RTK Hazardous Substances: This material is listed.

Canada WHMIS (Canada) Class A: Compressed gas.

Class D-1A: Material causing immediate and serious toxic effects (Very toxic). Class E: Corrosive material Canadian NPRI: This material is listed.

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EMERGENCY PHONE NUMBER: (800) 424-9300; (202) 483-7616 SECTION XVI – OTHER INFORMATION

United States Label Requirements

CAUSES SEVERE RESPIRATORY TRACT, EYE AND SKIN BURNS. HARMFUL IF INHALED. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA. CONTENTS UNDER PRESSURE.

Canada Label Requirements

Class A: Compressed gas. Class D-1A: Material causing immediate and serious toxic effects (Very toxic). Class E: Corrosive material

Hazardous Material Information System (USA)

National Fire Protection

Association (USA)

Notice to reader: To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

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p. 1

3 1 0

He a lt h

Fire

Re a c t iv it y


2

3

0

H

Material Safety Data SheetAcetone MSDS


Product Name: Acetone

Catalog Codes: SLA3502, SLA1645, SLA3151, SLA3808

CAS#: 67-64-1

RTECS: AL3150000

TSCA: TSCA 8(b) inventory: Acetone


Synonym: 2-propanone; Dimethyl Ketone;Dimethylformaldehyde; Pyroacetic Acid

Chemical Name: Acetone

Chemical Formula: C3-H6-O









Composition:


Acetone 67-64-1 100

Toxicological Data on Ingredients: Acetone: ORAL (LD50): Acute: 5800 mg/kg [Rat]. 3000 mg/kg [Mouse]. 5340 mg/kg[Rabbit]. VAPOR (LC50): Acute: 50100 mg/m 8 hours [Rat]. 44000 mg/m 4 hours [Mouse].


Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female,Reproductive system/toxin/male [SUSPECTED]. The substance is toxic to central nervous system (CNS). The substance maybe toxic to kidneys, the reproductive system, liver, skin. Repeated or prolonged exposure to the substance can produce targetorgans damage.


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p. 2

Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.










Flash Points: CLOSED CUP: -20°C (-4°F). OPEN CUP: -9°C (15.8°F) (Cleveland).

Flammable Limits: LOWER: 2.6% UPPER: 12.8%


Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks, of oxidizing materials, of acids.


Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back.

Special Remarks on Explosion Hazards:Forms explosive mixtures with hydrogen peroxide, acetic acid, nitric acid, nitric acid + sulfuric acid, chromic anydride, chromylchloride, nitrosyl chloride, hexachloromelamine, nitrosyl perchlorate, nitryl perchlorate, permonosulfuric acid, thiodiglycol +hydrogen peroxide, potassium ter-butoxide, sulfur dichloride, 1-methyl-1,3-butadiene, bromoform, carbon, air, chloroform,thitriazylperchlorate.



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p. 3



Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis.

Storage:Store in a segregated and approved area (flammables area) . Keep container in a cool, well-ventilated area. Keep containertightly closed and sealed until ready for use. Keep away from direct sunlight and heat and avoid all possible sources of ignition(spark or flame).





Exposure Limits:TWA: 500 STEL: 750 (ppm) from ACGIH (TLV) [United States] TWA: 750 STEL: 1000 (ppm) from OSHA (PEL) [UnitedStates] TWA: 500 STEL: 1000 [Austalia] TWA: 1185 STEL: 2375 (mg/m3) [Australia] TWA: 750 STEL: 1500 (ppm) [UnitedKingdom (UK)] TWA: 1810 STEL: 3620 (mg/m3) [United Kingdom (UK)] TWA: 1800 STEL: 2400 from OSHA (PEL) [UnitedStates]Consult local authorities for acceptable exposure limits.



Odor: Fruity. Mint-like. Fragrant. Ethereal

Taste: Pungent, Sweetish


Color: Colorless. Clear



Melting Point: -95.35 (-139.6°F)



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p. 4

Vapor Pressure: 24 kPa (@ 20°C)

Vapor Density: 2 (Air = 1)



Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2



Solubility: Easily soluble in cold water, hot water.




Conditions of Instability: Excess heat, ignition sources, exposure to moisture, air, or water, incompatible materials.

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.







Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3000 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 44000 mg/m3 4 hours [Mouse].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. DEVELOPMENTAL TOXICITY: ClassifiedReproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED]. Causes damage to the following organs:central nervous system (CNS). May cause damage to the following organs: kidneys, the reproductive system, liver, skin.

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).


Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenicity) based on studies with yeast (S. cerevisiae), bacteria, and hamster fibroblast cells.May cause reproductive effects (fertility) based upon animal studies. May contain trace amounts of benzene and formaldehydewhich may cancer and birth defects. Human: passes the placental barrier.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. May be harmful if absorbed through the skin. Eyes: Causeseye irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Inhalation:Inhalation at high concentrations affects the sense organs, brain and causes respiratory tract irritation. It also may affect theCentral Nervous System (behavior) characterized by dizzness, drowsiness, confusion, headache, muscle weakeness, andpossibly motor incoordination, speech abnormalities, narcotic effects and coma. Inhalation may also affect the gastrointestinaltract (nausea, vomiting). Ingestion: May cause irritation of the digestive (gastrointestinal) tract (nausea, vomiting). It may also

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p. 5

affect the Central Nevous System (behavior), characterized by depression, fatigue, excitement, stupor, coma, headache,altered sleep time, ataxia, tremors as well at the blood, liver, and urinary system (kidney, bladder, ureter) and endocrinesystem. May also have musculoskeletal effects. Chronic Potential Health Effects: Skin: May cause dermatitis. Eyes: Eyeirritation.


Ecotoxicity:Ecotoxicity in water (LC50): 5540 mg/l 96 hours [Trout]. 8300 mg/l 96 hours [Bluegill]. 7500 mg/l 96 hours [Fatthead Minnow].0.1 ppm any hours [Water flea].









Identification: : Acetone UNNA: 1090 PG: II



Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to causereproductive harm (male) which would require a warning under the statute: Benzene California prop. 65: This product containsthe following ingredients for which the State of California has found to cause birth defects which would require a warning underthe statute: Benzene California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause cancer which would require a warning under the statute: Benzene, Formaldehyde Connecticut hazardousmaterial survey.: Acetone Illinois toxic substances disclosure to employee act: Acetone Illinois chemical safety act: AcetoneNew York release reporting list: Acetone Rhode Island RTK hazardous substances: Acetone Pennsylvania RTK: AcetoneFlorida: Acetone Minnesota: Acetone Massachusetts RTK: Acetone Massachusetts spill list: Acetone New Jersey: AcetoneNew Jersey spill list: Acetone Louisiana spill reporting: Acetone California List of Hazardous Substances (8 CCR 339):Acetone TSCA 8(b) inventory: Acetone TSCA 4(a) final test rules: Acetone TSCA 8(a) IUR: Acetone



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).

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p. 6

DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S9- Keep container in a well-ventilated place. S16- Keep away from sources ofignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0



Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:



References:-Material safety data sheet issued by: la Commission de la SantÃ© et de la SÃ©curitÃ© du Travail du QuÃ©bec. -The Sigma-Aldrich Library of Chemical Safety Data, Edition II. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New YorkN.Y., Van Nostrand Reinold, 1987. LOLI, RTECS, HSDB databases. Other MSDSs


Created: 10/10/2005 08:13 PM

Last Updated: 05/21/2013 12:00 PM


Page 281 of 485

SAFETY DATA SHEET

1. IdentificationProduct Name Methanesulfonic acid

Cat No. : AC125620000; AC125620010; AC125620050; AC125622500

Synonyms MSA




Label Elements

Signal WordDanger

Hazard StatementsMay be corrosive to metalsHarmful if swallowedHarmful in contact with skinHarmful if inhaledCauses severe skin burns and eye damageCauses serious eye damageMay cause respiratory irritation

______________________________________________________________________________________________

Page 1 / 8

Target Organs - Respiratory system.

Creation Date 27-Feb-2012

Acute oral toxicity Category 4


Acute dermal toxicity Category 4


Acute Inhalation Toxicity - Vapors Category 4


Skin Corrosion/irritation Category 1 B



Revision Number 1

Specific target organ toxicity (single exposure) Category 3

Corrosive to metals Category 1

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______________________________________________________________________________________________

Precautionary StatementsPreventionWash face, hands and any exposed skin thoroughly after handlingDo not eat, drink or smoke when using this productWear protective gloves/protective clothing/eye protection/face protectionAvoid breathing dust/fume/gas/mist/vapors/sprayUse only outdoors or in a well-ventilated areaAvoid release to the environmentResponseCall a POISON CENTER or doctor/physician if you feel unwellInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingCall a POISON CENTER or doctor/physician if you feel unwellSkinWash contaminated clothing before reuseIF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/showerImmediately call a POISON CENTER or doctor/physicianEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingImmediately call a POISON CENTER or doctor/physicianIngestionRinse mouthDo NOT induce vomitingIF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwellStorageStore locked upStore in a well-ventilated place. Keep container tightly closedStore in corrosive resistant polypropylene container with a resistant inlinerDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) None identified


Component CAS-No Weight %Methanesulfonic acid 75-75-2 70

Water 7732-18-5 30


Eye Contact Immediate medical attention is required. Rinse immediately with plenty of water, also underthe eyelids, for at least 15 minutes.

Skin Contact Immediate medical attention is required. Wash off immediately with plenty of water for atleast 15 minutes.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouthresuscitation if victim ingested or inhaled the substance; induce artificial respiration with arespiratory medical device. Immediate medical attention is required.

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Revision Date 10-Feb-2015Methanesulfonic acid

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______________________________________________________________________________________________

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms/effects Causes burns by all exposure routes. Product is a corrosive material. Use of gastriclavage or emesis is contraindicated. Possible perforation of stomach or esophagus shouldbe investigated: Ingestion causes severe swelling, severe damage to the delicate tissueand danger of perforation


5. Fire-fighting measuresSuitable Extinguishing Media Dike fire-control water for later disposal. Carbon dioxide (CO 2). Dry chemical. Use water

spray to cool unopened containers. chemical foam.


Flash Point > 110 °C / > 230 °FMethod - No information available

Autoignition Temperature No information availableExplosion Limits


Specific Hazards Arising from the ChemicalKeep product and empty container away from heat and sources of ignition.

Hazardous Combustion ProductsCarbon monoxide (CO) Carbon dioxide (CO2) Sulfur oxidesProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Ensure adequate ventilation. Use personal protective equipment.Environmental Precautions See Section 12 for additional ecological information.


Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder,sawdust). Keep in suitable, closed containers for disposal.

7. Handling and storageHandling Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing. Use only in

area provided with appropriate exhaust ventilation. Wear personal protective equipment.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed. Keep awayfrom direct sunlight. Corrosives area.



______________________________________________________________________________________________

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Health3

Flammability0

Instability0

Methanesulfonic acid

Physical hazardsN/A


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______________________________________________________________________________________________

9. Physical and chemical propertiesPhysical State LiquidAppearance ColorlessOdor No information availableOdor Threshold No information availablepH No information availableMelting Point/Range -54 °C / -65 °FBoiling Point/Range No information availableFlash Point > 110 °C / > 230 °FEvaporation Rate No information availableFlammability (solid,gas) No information availableFlammability or explosive limits


Vapor Pressure <1 mbar @ 20 °CVapor Density No information availableRelative Density 1.350Solubility No information availablePartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature No information availableViscosity No information availableMolecular Formula C H4 O3 SMolecular Weight 96.1




Conditions to Avoid Excess heat. Exposure to light. Incompatible products. Exposure to moisture.

Incompatible Materials Bases, Strong acids, Amines, Alkaline, Strong reducing agents, lead, Hydrogen fluoride,Metals, copper

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Sulfur oxides


Hazardous Reactions Corrosive to metals.

______________________________________________________________________________________________

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Methanesulfonic acid


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______________________________________________________________________________________________


Oral LD50 Category 4. ATE = 300 - 2000 mg/kg.Dermal LD50 Category 4. ATE = 1000 - 2000 mg/kg.Vapor LC50 Category 4.Component Information

Component LD50 Oral LD50 Dermal LC50 InhalationMethanesulfonic acid 649 mg/kg ( Rat ) 1000 - 2000 mg/kg ( Rabbit ) 1.3 mg/L/6h ( Rat )




Irritation Causes burns by all exposure routes



Component CAS-No IARC NTP ACGIH OSHA MexicoMethanesulfonic acid 75-75-2 Not listed Not listed Not listed Not listed Not listed

Water 7732-18-5 Not listed Not listed Not listed Not listed Not listedMutagenic Effects Not mutagenic in AMES Test




STOT - single exposure Respiratory systemSTOT - repeated exposure None known



Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.Possible perforation of stomach or esophagus should be investigated: Ingestion causessevere swelling, severe damage to the delicate tissue and danger of perforation


Other Adverse Effects See actual entry in RTECS for complete information.

12. Ecological informationEcotoxicity Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system. Do not emptyinto drains.

Component Freshwater Algae Freshwater Fish Microtox Water FleaMethanesulfonic acid Not listed Oncorhynchus mykiss:

LC50=73 mg/L 96hNot listed 12 mg/L EC50 = 48 h

Persistence and Degradability No information availableBioaccumulation/ Accumulation No information available.


Component log PowMethanesulfonic acid -2.4

13. Disposal considerations

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Methanesulfonic acid Revision Date 10-Feb-2015

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Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as ahazardous waste. Chemical waste generators must also consult local, regional, andnational hazardous waste regulations to ensure complete and accurate classification.


UN-No UN3265Proper Shipping Name CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.Proper technical name (METHANESULFONIC ACID)Hazard Class 8Packing Group II

TDG UN-No UN3265Proper Shipping Name CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.Hazard Class 8Packing Group II

IATA UN-No 3265Proper Shipping Name CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.*Hazard Class 8Packing Group II

IMDG/IMO UN-No 3265Proper Shipping Name CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.Hazard Class 8Packing Group II



Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLMethanesulfonic acid X X - 200-898-6 - X X X X X

Water X X - 231-791-2 - X - X X XLegend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.




SARA 311/312 Hazardous CategorizationAcute Health Hazard YesChronic Health Hazard NoFire Hazard NoSudden Release of Pressure Hazard NoReactive Hazard No

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______________________________________________________________________________________________






State Right-to-KnowComponent Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Methanesulfonic acid - X - - -

Water - - X - -







WHMIS Hazard Class E Corrosive materialD1B Toxic materials



Creation Date 27-Feb-2012Revision Date 10-Feb-2015Print Date 10-Feb-2015Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard


DisclaimerThe information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at thedate of its publication. The information given is designed only as a guide for safe handling, use, processing, storage,

______________________________________________________________________________________________

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______________________________________________________________________________________________

transportation, disposal and release and is not to be considered as a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterial or in any process, unless specified in the text.

End of SDS

______________________________________________________________________________________________

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Page 289 of 485

Product Name Activated Carbon Revised 10/10Product ID 98913

SECTION 1PRODUCT NAME: Activated Carbon SYNONYMS: n/aPRODUCT CODES: 98913

MANUFACTURER: Aquascape, Inc.DIVISION: n/aADDRESS: 901 Aqualand Way, St. Charles, IL 60174EMERGENCY PHONE:

866-877-6637 CANADA: 866-766-3426

OTHER CALLS: 630-659-2000 FAX: 630-659-2100

CHEMICAL NAME: Carbon CHEMICAL FAMILY:

Element

CHEMICAL FORMULA:

n/a

PREPARED BY: Aquascape, Inc.

SECTION 2

HAZARDOUS INGREDIENTS

None known.

COMPONENTS All ingredients not precisely identified are proprietary.

OTHER INGREDIENTS:

Proprietary blend Activated Carbon

CAS NO. n/a 7440-44-0% WT @ @OVER 3% no yes

OSHA PEL: noneACGIH TLV: n/aSARA 313 REPORTABLE

no

SECTION 3

EMERGENCY OVERVIEW:

Appearance: Black Pellet

Odor: Odorless

POTENTIAL HEALTH EFFECTSEYES: Slight Irritation may

occur

May be used to comply with OSHA's Hazard Communications Standard, 29 CFR 1910.1200. Standard must be consulted for specific requirements.


HAZARDS IDENTIFICATION

PRODUCT AND COMPANY IDENTIFICATION

COMPOSITION/INFORMATION ON INGREDIENTS

Aquascape, Inc. | MSDS | Activated Carbon 1

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SKIN: none INGESTION: Excessive ingestion may cause nausea or gastrointestinal discomfortINHALATION: n/aACUTE AND CHRONIC HEALTH HAZARDS:

None known.

MEDICAL CONDITIONS GENERALLY AGGRAVATED BY EXPOSURE:

None known.

CARCINOGENICITYOSHA: n/aIARC: n/aACGIH: n/aOTHER: n/aNTP: n/a

SECTION 4

EYES: Flush eyes thoroughly with running water for 15 minutes while keeping the eyelids wide open.

SKIN: Wash the affected area thoroughly with soap and water.

Clean Clothing

Consult physician if redness or irritation persists.

INGESTION: Thoroughly rinse mouth with water

Drink plenty of fluids

Slight gastrointestinal discomfort may occur

INHALATION: n/a

SECTION 5

SUITABLE EXTINGUISHING MEDIA

Dry chemical, water fog, foam

EXTINGUISHING MEDIA WHICH MUST NOT BE USED FOR SAFETY REASONS

none

SPECIAL EXPOSURE HAZARDS IN A FIRE

none

SPECIAL PROTECTIVE EQUIPMENT FOR FIRE-FIGHTERS

none

FIRST AID MEASURES

FIRE-FIGHTING MEASURES


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OTHER INFORMATION

none

SECTION 6

PERSONAL PRECAUTIONS Follow protective measures provided in sections 5 and 8

Keep away materials and products which areincompatible with product specified in section 10

ENVIRONMENTAL PRECAUTIONS Rinse spilled product to dillute areas of direct contact.METHODS FOR CLEAN UP Wear suitable clothing and protective equipment

Recover or mop up excess material and reuse wherever possible. Absorb unusable product with suitable material and dispose of in accordance with Section 13.Collect product with suitable means avoiding dust formation.

SECTION 7

HANDLING Maintain good housekeeping practices

Wash hands after use

Avoid contact with potable water or food

STORAGE Keep in a dry place

Keep away from direct sunlight

Keep away from heat

Keep away from incompatible products specified in section 10

Keep only in the original container at temperature not

exceeding 40C (104F)

SECTION 8

ENGINEERING CONTROLS: n/a

VENTILATION: Wear suitable NIOSH approved dust masks or respiratory protector.

RESPIRATORY PROTECTION: none required

EYE PROTECTION: ANSI approved safety glasses with side protection or goggles.

SKIN PROTECTION: Wear suitable protective clothing

HYGIENIC PRACTICES: Handle in accordance with good hygiene and safety practice.

SECTION 9

GENERAL INFORMATION

APPEARANCE: Black Pelletized

ODOR: Odorless

ACCIDENTAL RELEASE MEASURES

HANDLING AND STORAGE

EXPOSURE CONTROLS/PERSONAL PROTECTION

PHYSICAL AND CHEMICAL PROPERTIES


Page 292 of 485

IMPORTANT HEALTH SAFETY AND ENVIRONMENTAL INFORMATIONpH: n/aBOILING POINT 8721 F

FLASH POINT not applicable

MELTING POINT not applicable

FLAMMABILITY (SOLID, GAS)

non flammable

EXPLOSIVE PROPERTIES

non-explosive

VAPOR PRESSURE:

not applicable

VAPOR DENSITY: not applicableBULK DENSITY not availableEVAPORATION RATE:

not applicableSOLUBILITY IN WATER:

complete

DECOMPOSITION TEMPERATURE

not applicable

VISCOSITY: not applicable

SECTION 10

STABILITY: Stable under normal conditions of use.

CONDITIONS TO AVOID:

none

INCOMPATIBILITY (MATERIAL TO AVOID):

none

HAZARDOUS DECOMPOSITION OR BY-PRODUCTS:

none known

HAZARDOUS POLYMERIZATION:

n/a

CONDITIONS TO AVOID:

Excessive heat, moisture and contamination of any kind

SECTION 11

TOXICOLOGICAL DATA:ACUTE ORAL TOXICITY

none known

ACUTE INHALATION TOXICITY

none known

ACUTE DERMAL IRRITATION/CORROSION

none known

SKIN IRRITATION none

EYE IRRITATION acute

SENSITIZATION none

STABILITY AND REACTIVITY

TOXICOLOGICAL INFORMATION


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CHRONIC TOXICITY n/a

CHRONIC TOXICITY/ CARCINOGENIC DESIGNATION:

none known

SECTION 12

ECOTOXICITY EFFECTS:

ACUTE TOXICITY: none knownMOBILITY: not applicablePERSISTENCE AND DEGRADABILITY: none knownBIOACCUMULATIVE POTENTIAL: is not known to accumulate

SECTION 13

WASTE TREATMENT: Dispose of within current local and state regulations.

No special method required.

PACKAGING TREATMENT: Consult federal, state, and local regulations regardingthe proper disposal of emptied containers.

RCRA HAZARD CLASS: n/a

SECTION 14

U.S. DEPARTMENT OF TRANSPORTATIONPROPER SHIPPING

NAME: Chemicals Not Otherwise Indexed (NOI)

Not Hazardous

HAZARD CLASS: Not RegulatedID NUMBER: n/a

LABEL STATEMENT:

none

WATER TRANSPORTATIONPROPER SHIPPING


Not Hazardous


LABEL STATEMENT:

noneAIR TRANSPORTATIONPROPER SHIPPING


Not Hazardous


LABEL STATEMENT:

none

SECTION 15

ECOLOGICAL INFORMATION

DISPOSAL CONSIDERATIONS

TRANSPORT INFORMATION

REGULATORY INFORMATION


Page 294 of 485

Preparation does not contain ingredients listed as a dangerous substance in Annex 1 of the EEC directive 67/548.

SECTION 16

KEEP OUT OF REACH OF CHILDREN

Although the information and recommendations set forth in this sheet are believed to be correct as of the date hereof, Aquascape, Inc. makes no representation as to the completeness or accuracy of such information and recommendations. Aquascape, Inc. shall in no event be responsible for any damages of whatsoever nature directly or indirectly resulting from the publication or use of or reliance upon such information and recommendations. You are encouraged to advise anyone working with or exposed to such products of the information contained herein.

No Warranty, either expressed or implied, of merchantability or fitness or of any other nature with respect to the product or to the information and recommendations hereinmade hereunder.

OTHER INFORMATION


Page 295 of 485

SAFETY DATA SHEETCreation Date 27-Jan-2015 Revision Date 27-Jan-2015 Revision Number 1

1. IdentificationProduct Name Hyflo *Super-Cel* Filter Aid

Cat No. : H333-3

Synonyms Infusorial earth




Label Elements

Signal WordDanger

Hazard StatementsCauses serious eye irritationMay cause cancerMay cause respiratory irritationMay cause damage to organs through prolonged or repeated exposure



Serious Eye Damage/Eye Irritation Category 2Carcinogenicity Category 1ASpecific target organ toxicity (single exposure) Category 3

______________________________________________________________________________________________

Target Organs - Respiratory system.

Page 1 / 7

Specific target organ toxicity - (repeated exposure) Category 2Target Organs - Lungs.

Page 296 of 485

______________________________________________________________________________________________Hyflo *Super-Cel* Filter Aid Revision Date 27-Jan-2015

Precautionary StatementsPreventionObtain special instructions before useDo not handle until all safety precautions have been read and understoodUse personal protective equipment as requiredWash face, hands and any exposed skin thoroughly after handlingWear eye/face protectionDo not breathe dust/fume/gas/mist/vapors/sprayUse only outdoors or in a well-ventilated areaResponseIF exposed or concerned: Get medical attention/adviceInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIf eye irritation persists: Get medical advice/attentionStorageStore locked upStore in a well-ventilated place. Keep container tightly closedDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) None identifiedOther hazardsWARNING! This product contains a chemical known in the State of California to cause cancer.


Component CAS-No Weight %Silica, amorphous, diatomaceous earth 68855-54-9 100

Silica, cristobalite 14464-46-1 < 40Quartz 14808-60-7 < 4



Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention ifsymptoms occur.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Get medical attention if symptomsoccur.


Most important symptoms/effects No information available.Notes to Physician Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media Substance is nonflammable; use agent most appropriate to extinguish surrounding fire.


Page 297 of 485


Flash Point Not applicableMethod - No information available



Specific Hazards Arising from the ChemicalNon-combustible. None reasonably foreseeable.

Hazardous Combustion ProductsNone under normal use conditionsProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Use personal protective equipment. Ensure adequate ventilation. Avoid dust formation.

Avoid contact with skin, eyes and clothing.Environmental Precautions Avoid release to the environment.


Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dustformation.

7. Handling and storageHandling Wear personal protective equipment. Ensure adequate ventilation. Avoid dust formation.

Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation.

Storage Keep containers tightly closed in a dry, cool and well-ventilated place.

8. Exposure controls / personal protectionExposure Guidelines

Health2

Flammability0

Instability0

Physical hazardsN/A

Component ACGIH TLV OSHA PEL NIOSH IDLHSilica, cristobalite TWA: 0.025 mg/m3 (Vacated) TWA: 0.05 mg/m3 IDLH: 25 mg/m3

TWA: 0.05 mg/m3

Quartz TWA: 0.025 mg/m3 (Vacated) TWA: 0.1 mg/m3 IDLH: 50 mg/m3

TWA: 0.05 mg/m3

Component Quebec Mexico OEL (TWA) Ontario TWAEV

Silica, cristobalite TWA: 0.05 mg/m3 TWA: 0.05 mg/m3 TWA: 0.05 mg/m3

Quartz TWA: 0.1 mg/m3 TWA: 0.1 mg/m3 TWA: 0.10 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial HygienistsOSHA - Occupational Safety and Health AdministrationNIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health



Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described byOSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

Page 298 of 485


9. Physical and chemical propertiesPhysical State SolidAppearance Light greyOdor OdorlessOdor Threshold No information availablepH 5 - 10Melting Point/Range 1710 °C / 3110 °FBoiling Point/Range 2230 °C / 4046 °FFlash Point Not applicableEvaporation Rate No information availableFlammability (solid,gas) No information availableFlammability or explosive limits


Vapor Pressure 10 mmHg @ 1732 °CVapor Density No information availableRelative Density 1.9 - 2.35Solubility Insoluble in waterPartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature No information availableViscosity No information availableMolecular Formula SiO2Molecular Weight 60.0843




Conditions to Avoid Avoid dust formation.

Incompatible Materials None known

Hazardous Decomposition Products None under normal use conditions




Product Information No acute toxicity information is available for this productComponent Information

Component LD50 Oral LD50 Dermal LC50 InhalationQuartz 500 mg/kg ( Rat ) Not listed Not listed




Irritation Irritating to eyes and respiratory system

EN166.




Page 299 of 485




Component CAS-No IARC NTP ACGIH OSHA MexicoSilica, amorphous,diatomaceous earth

68855-54-9 Not listed Not listed Not listed Not listed Not listed

Silica, cristobalite 14464-46-1 Group 1 Not listed A2 X Not listedQuartz 14808-60-7 Group 1 Known A2 X Not listed

IARC: (International Agency for Research on Cancer) IARC: (International Agency for Research on Cancer)Group 1 - Carcinogenic to HumansGroup 2A - Probably Carcinogenic to HumansGroup 2B - Possibly Carcinogenic to Humans

NTP: (National Toxicity Program) NTP: (National Toxicity Program)Known - Known CarcinogenReasonably Anticipated - Reasonably Anticipated to be a HumanCarcinogen

ACGIH: (American Conference of Governmental IndustrialHygienists)

A1 - Known Human CarcinogenA2 - Suspected Human CarcinogenA3 - Animal CarcinogenACGIH: (American Conference of Governmental Industrial Hygienists)

Mutagenic Effects No information available




STOT - single exposure Respiratory systemSTOT - repeated exposure Lungs





Other Adverse Effects The toxicological properties have not been fully investigated.






14. Transport informationDOT Not regulatedTDG Not regulatedIATA Not regulatedIMDG/IMO Not regulated


All of the components in the product are on the following Inventory lists: Australia X = listed China Canada The product isclassified and labeled according to EC directives or corresponding national laws The product is classified and labeled in

Page 300 of 485


accordance with Directive 1999/45/EC Europe TSCA Korea Philippines Japan


Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLSilica, amorphous,diatomaceous earth

X X - 272-489-0 - X X X X X

Silica, cristobalite X X - 238-455-4 - X X X X XQuartz X X - 238-878-4 - X X X X X

Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.




SARA 311/312 Hazardous CategorizationAcute Health Hazard YesChronic Health Hazard YesFire Hazard NoSudden Release of Pressure Hazard NoReactive Hazard No





California Proposition 65 This product contains the following Proposition 65 chemicals:

Component CAS-No California Prop. 65 Prop 65 NSRL Category

Quartz 14808-60-7 Carcinogen - Carcinogen


Silica, amorphous,diatomaceous earth

- - X - -

Silica, cristobalite X X X X -

Quartz X X X X X



U.S. Department of Homeland Security

Page 301 of 485


This product does not contain any DHS chemicals.




WHMIS Hazard Class D2A Very toxic materialsD2B Toxic materials



Creation Date 27-Jan-2015Revision Date 27-Jan-2015Print Date 27-Jan-2015Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard



End of SDS

Page 302 of 485

SAFETY DATA SHEET

1. IdentificationProduct Name Raney NickelÒ, activated catalyst, 50% slurry in water

Cat No. : AC395920000; AC395921000; AC395925000

Synonyms Catalyst for hydrogenation.




Label Elements

Signal WordDanger

Hazard StatementsIn contact with water releases flammable gasCauses skin irritationCauses eye irritationMay cause an allergic skin reactionMay cause cancerMay cause respiratory irritation. May cause drowsiness and dizziness

______________________________________________________________________________________________

Page 1 / 8

Specific target organ toxicity - (repeated exposure) Category 1Target Organs - Skin.

Creation Date 24-Nov-2010

Skin Corrosion/irritation Category 2




Skin Sensitization Category 1


Carcinogenicity Category 1B


Specific target organ toxicity (single exposure) Category 3

Revision Number 1

Target Organs - Respiratory system, Central nervous system (CNS).

Substances/mixtures which, in contact with water, emitflammable gases

Category 2

Page 303 of 485

______________________________________________________________________________________________

Causes damage to organs through prolonged or repeated exposure

Precautionary StatementsPreventionObtain special instructions before useDo not handle until all safety precautions have been read and understoodWear protective gloves/protective clothing/eye protection/face protectionHandle under inert gas. Protect from moistureWash face, hands and any exposed skin thoroughly after handlingContaminated work clothing should not be allowed out of the workplaceUse only outdoors or in a well-ventilated areaDo not breathe dust/fume/gas/mist/vapors/sprayDo not eat, drink or smoke when using this productResponseIF exposed or concerned: Get medical attention/adviceInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingSkinTake off contaminated clothing and wash before reuseIF ON SKIN: Wash with plenty of soap and waterIf skin irritation or rash occurs: Get medical advice/attentionEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIf eye irritation persists: Get medical advice/attentionFireEvacuate areaUse CO2, dry chemical, or foamStorageStore locked upStore in a dry placeStore in a well-ventilated place. Keep container tightly closedDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) Toxic to aquatic life with long lasting effects


Component CAS-No Weight %Nickel 7440-02-0 46-49Water 7732-18-5 39.5

Aluminium powder 7429-90-5 1-4



Skin Contact Obtain medical attention. Wash off immediately with plenty of water for at least 15 minutes.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Obtain medical attention.

______________________________________________________________________________________________

Page 2 / 8

Raney NickelÒ, activated catalyst, 50% slurry in water Revision Date 10-Feb-2015

Page 304 of 485

______________________________________________________________________________________________


Most important symptoms/effects May cause allergic skin reaction. Symptoms of allergic reaction may include rash, itching,swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chestpain, muscle pain or flushing


5. Fire-fighting measuresSuitable Extinguishing Media Water spray. Carbon dioxide (CO 2). Dry chemical. Use water spray to cool unopened

containers. chemical foam.


Flash Point No information availableMethod - No information available



Specific Hazards Arising from the ChemicalExplosive properties. Self-heating; exposure to air may cause substance to self-heat without an energy supply.

Hazardous Combustion ProductsBurning produces obnoxious and toxic fumesProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Ensure adequate ventilation. Use personal protective equipment.Environmental Precautions Do not flush into surface water or sanitary sewer system. See Section 12 for additional

ecological information.


Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder,sawdust). Keep in suitable, closed containers for disposal. Remove all sources of ignition.Use spark-proof tools and explosion-proof equipment. Do not flush into surface water orsanitary sewer system.

7. Handling and storageHandling Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing. Take

precautionary measures against static discharges. Use only in area provided withappropriate exhaust ventilation. Use explosion-proof equipment. Use only non-sparkingtools. Minimize dust generation and accumulation. Wear personal protective equipment.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed. Keep awayfrom heat and sources of ignition. Flammables area. Material can explode if dry. Keep attemperatures below 40°C. Do not freeze.

8. Exposure controls / personal protection

______________________________________________________________________________________________

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Instability0

Raney NickelÒ, activated catalyst, 50% slurry in water

Physical hazardsW


Health3

Flammability2

Page 305 of 485

______________________________________________________________________________________________

Exposure Guidelines

9. Physical and chemical propertiesPhysical State Slurry LiquidAppearance Dark greyOdor OdorlessOdor Threshold No information availablepH 10-11 1500 g/L aq.solMelting Point/Range No data availableBoiling Point/Range No information availableFlash Point No information availableEvaporation Rate No information availableFlammability (solid,gas) Not applicableFlammability or explosive limits


Vapor Pressure 23.5 mbar @ 20 °CVapor Density No information availableRelative Density No information availableSolubility No information availablePartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature > 100°CViscosity No information availableMolecular Formula NiMolecular Weight 58.69

______________________________________________________________________________________________

Page 4 / 8

NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health

Aluminium powder TWA: 1 mg/m3 (Vacated) TWA: 15 mg/m3

(Vacated) TWA: 5 mg/m3

TWA: 15 mg/m3

TWA: 5 mg/m3

TWA: 10 mg/m3

TWA: 5 mg/m3


Engineering Measures Use explosion-proof electrical/ventilating/lighting/equipment. Ensure that eyewash stationsand safety showers are close to the workstation location.

Raney NickelÒ, activated catalyst, 50% slurry in water




Nickel TWA: 1 mg/m3 TWA: 1 mg/m3 TWA: 1 mg/m3


Aluminium powder TWA: 10 mg/m3 TWA: 5 mg/m3 TWA: 10 mg/m3 TWA: 5 mg/m3 TWA: 1 mg/m3


Component ACGIH TLV

Legend


OSHA PEL NIOSH IDLH

ACGIH - American Conference of Governmental Industrial Hygienists

Nickel TWA: 1.5 mg/m3

OSHA - Occupational Safety and Health Administration

(Vacated) TWA: 1 mg/m3

TWA: 1 mg/m3

IDLH: 10 mg/m3

TWA: 0.015 mg/m3

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______________________________________________________________________________________________


Reactive Hazard Yes

Stability Stable.

Conditions to Avoid Heat, flames and sparks. Keep away from open flames, hot surfaces and sources ofignition. Exposure to air. Incompatible products.

Incompatible Materials Acids, Ammonia, Ammonium nitrate: fertilizers capable of self-sustaining decomposition,Halogens, Fluorine, Organic materials, nitriles

Hazardous Decomposition Products Burning produces obnoxious and toxic fumes




Product InformationOral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.Vapor LC50 Based on ATE data, the classification criteria are not met. ATE > 20 mg/l.Component Information

Component LD50 Oral LD50 Dermal LC50 InhalationNickel 9000 mg/kg ( Rat ) Not listed Not listed




Irritation Irritating to eyes, respiratory system and skin Vapors may cause drowsiness and dizziness

Sensitization May cause sensitization by skin contact


Component CAS-No IARC NTP ACGIH OSHA MexicoNickel 7440-02-0 Group 2B Reasonably

AnticipatedNot listed X Not listed

Water 7732-18-5 Not listed Not listed Not listed Not listed Not listedAluminium powder 7429-90-5 Not listed Not listed Not listed Not listed Not listed





STOT - single exposure Respiratory system Central nervous system (CNS)STOT - repeated exposure Skin



Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tinglingof the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing


______________________________________________________________________________________________

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Revision Date 10-Feb-2015Raney NickelÒ, activated catalyst, 50% slurry in water

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______________________________________________________________________________________________


12. Ecological informationEcotoxicity Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system. Do not emptyinto drains. The product contains following substances which are hazardous for the environment. Toxic to aquatic organisms, maycause long-term adverse effects in the aquatic environment. Very toxic to aquatic organisms, may cause long-term adverse effectsin the aquatic environment.

Component Freshwater Algae Freshwater Fish Microtox Water FleaNickel EC50 = 0.1 mg/L 72h

EC50 = 0.18 mg/L 72h10.4 mg/L LC50 96 h 1.3

mg/L LC50 96 h 100 mg/LLC50 96 h

Not listed EC50 = 510 µg/L 96h

Persistence and Degradability Insoluble in waterBioaccumulation/ Accumulation No information available.

Mobility . Is not likely mobile in the environment due its low water solubility.




UN-No UN1378Proper Shipping Name METAL CATALYST, WETTEDHazard Class 4.2Packing Group II

TDG UN-No UN1378Proper Shipping Name METAL CATALYST, WETTEDHazard Class 4.2Packing Group II

IATA UN-No 1378Proper Shipping Name METAL CATALYST, WETTEDHazard Class 4.2Packing Group II

IMDG/IMO UN-No 1378Proper Shipping Name METAL CATALYST, WETTEDHazard Class 4.2Packing Group II



Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLNickel X X - 231-111-4 - X - X X XWater X X - 231-791-2 - X - X X X

Aluminium powder X X - 231-072-3 - X - X X XLegend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.

______________________________________________________________________________________________

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______________________________________________________________________________________________

N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.



SARA 313Component CAS-No Weight % SARA 313 - Threshold

Values %

Nickel 7440-02-0 46-49 0.1

Aluminium powder 7429-90-5 1-4 1.0

SARA 311/312 Hazardous CategorizationAcute Health Hazard YesChronic Health Hazard YesFire Hazard NoSudden Release of Pressure Hazard NoReactive Hazard Yes

Clean Water ActComponent CWA - Hazardous

SubstancesCWA - Reportable

QuantitiesCWA - Toxic Pollutants CWA - Priority Pollutants

Nickel - - X X

Clean Air ActComponent HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors

Nickel X -


CERCLAThis material, as supplied, contains one or more substances regulated as a hazardous substance under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Nickel 100 lb -

California Proposition 65 This product contains the following Proposition 65 chemicals:

Component CAS-No California Prop. 65 Prop 65 NSRL Category

Nickel 7440-02-0 Carcinogen - Carcinogen


Nickel X X X X X

Water - - X - -

Aluminium powder X X X - X


Reportable Quantity (RQ): NDOT Marine Pollutant N

______________________________________________________________________________________________

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______________________________________________________________________________________________

DOT Severe Marine Pollutant N

U.S. Department of Homeland SecurityThis product contains the following DHS chemicals:




WHMIS Hazard Class B6 Reactive flammable materialD2A Very toxic materials



Creation Date 24-Nov-2010Revision Date 10-Feb-2015Print Date 10-Feb-2015Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard



End of SDS

______________________________________________________________________________________________

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Raney NickelÒ, activated catalyst, 50% slurry in water Revision Date 10-Feb-2015

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1.1 Product identifiers Product name : Hydrochloric acid

Product Number : 339253 Brand : Sigma-Aldrich Index-No. : 017-002-01-X REACH No. : 01-2119484862-27-XXXX

CAS-No. : 7647-01-0









Classification according to Regulation (EC) No 1272/2008 Corrosive to metals (Category 1), H290 Skin corrosion (Category 1B), H314 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335


2.2 Label elements


Signal word Danger Hazard statement(s) H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing vapours. P280 Wear protective gloves/ protective clothing/ eye protection/ face

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protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove


none



3.2 Mixtures Formula : HCl Molecular weight : 36.46 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008


Hydrochloric acid


7647-01-0 231-595-7 017-002-01-X 01-2119484862-27-XXXX

Met. Corr. 1; Skin Corr. 1B; STOT SE 3; H290, H314, H335 Concentration limits: >= 25 %: Skin Corr. 1B, H314; 10 - < 25 %: Skin Irrit. 2, H315; 10 - < 25 %: Eye Irrit. 2, H319; >= 10 %: STOT SE 3, H335; >= 0.1 %: Met. Corr. 1, H290;

>= 25 - < 50 %











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5.2 Special hazards arising from the substance or mixture Hydrogen chloride gas Hydrogen chloride gas




6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.


6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.



7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non combustible liquids, corrosive








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Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 120 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.





a) Appearance Form: liquid Colour: light yellow

b) Odour pungent




-30 °C


> 100 °C - lit.





No data available

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k) Vapour pressure 170 mmHg at 21.1 °C 410 mmHg at 37.7 °C





No data available


No data available


No data available










10.5 Incompatible materials Bases, Amines, Alkali metals, Metals, permanganates, e.g. potassium permanganate, Fluorine, metal acetylides, hexalithium disilicide

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas In the event of fire: see section 5



Acute toxicity No data availableHydrochloric acid Inhalation: Inhalation may provoke the following symptoms: Respiratory irritation Cough Difficulty in breathing Pneumonia(Hydrochloric acid)

Skin corrosion/irritation Skin - Rabbit(Hydrochloric acid) Result: Causes burns.

Serious eye damage/eye irritation Eyes - Rabbit(Hydrochloric acid) Result: Corrosive to eyes

Respiratory or skin sensitisation Did not cause sensitisation on laboratory animals.(Hydrochloric acid)

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Germ cell mutagenicity No data available(Hydrochloric acid)

Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(Hydrochloric acid) (Hydrochloric acid)

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydrochloric acid)


No data available(Hydrochloric acid)

Specific target organ toxicity - single exposure The substance or mixture is classified as specific target organ toxicant, single exposure, category 3 with respiratory tract irritation.(Hydrochloric acid)

Specific target organ toxicity - repeated exposure The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard No aspiration toxicity classification(Hydrochloric acid)

Additional Information RTECS: MW4025000 Inhalation of vapors may cause:, burning sensation, Cough, wheezing, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema(Hydrochloric acid)


12.1 Toxicity Toxicity to fish LC50 - Lepomis macrochirus (Bluegill) - 24.6 mg/l - 96 h(Hydrochloric acid) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 4.91 mg/l - 48 h(Hydrochloric acid)



12.4 Mobility in soil No data available(Hydrochloric acid)


12.6 Other adverse effects May be harmful to aquatic organisms due to the shift of the pH. Do not empty into drains.




Page 316 of 485





14.2 UN proper shipping name ADR/RID: HYDROCHLORIC ACID IMDG: HYDROCHLORIC ACID IATA: Hydrochloric acid










H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.


Page 317 of 485

p. 1

3 2 0

He a lt h

Fire

Re a c t iv it y


2

3

0

H

Material Safety Data Sheet1,2-Dichloroethane MSDS


Product Name: 1,2-Dichloroethane


CAS#: 107-06-2

RTECS: KH9800000

TSCA: TSCA 8(b) inventory: 1,2-Dichloroethane

CI#: Not available.

Synonym: Ethylene dichloride

Chemical Formula: C2H4CL2









Composition:


{1,2-}Dichloroethane 107-06-2 100

Toxicological Data on Ingredients: 1,2-Dichloroethane: ORAL (LD50): Acute: 670 mg/kg [Rat]. 413 mg/kg [Mouse].DERMAL (LD50): Acute: 2800 mg/kg [Rabbit]. VAPOR (LC50): Acute: 1414.2 ppm 4 hour(s) [Rat].


Potential Acute Health Effects:Extremely hazardous in case of ingestion. Very hazardous in case of eye contact (irritant), of inhalation. Hazardous in case ofskin contact (irritant). Corrosive to skin and eyes on contact. Liquid or spray mist may produce tissue damage particularly onmucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist mayproduce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of theeye is characterized by redness, watering, and itching.

Potential Chronic Health Effects:Very hazardous in case of ingestion, of inhalation. CARCINOGENIC EFFECTS: Classified + (PROVEN) by OSHA. Classified2B (Possible for human.) by IARC. Classified 2 (Reasonably anticipated.) by NTP. MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs,the nervous system, liver, mucous membranes. Repeated or prolonged exposure to the substance can produce targetorgans damage. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation.Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchialinfection.

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p. 2


Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.

Skin Contact:If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible, protectingyour own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's exposed skin, suchas the hands : Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularlycareful to clean folds, crevices, creases and groin. If irritation persists, seek medical attention. Wash contaminated clothingbefore reusing.









Flash Points: CLOSED CUP: 13°C (55.4°F). OPEN CUP: 18°C (64.4°F).



Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks. Slightly flammable to flammable in presence of oxidizing materials.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive to explosive in presence of oxidizing materials.





Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

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p. 3

Large Spill:Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorbwith DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Usewater spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate allignition sources. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV.Check TLV on the MSDS and with local authorities.


Precautions:Keep locked up Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipmentcontaining material. Do not ingest. Do not breathe gas/fumes/ vapour/spray. Never add water to this product In case ofinsufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show thecontainer or the label. Avoid contact with skin and eyes

Storage:Flammable materials should be stored in a separate safety storage cabinet or room. Keep away from heat. Keep away fromsources of ignition. Keep container tightly closed. Keep in a cool, well-ventilated place. Ground all equipment containingmaterial. A refrigerated room would be preferable for materials with a flash point lower than 37.8°C (100°F).





Exposure Limits:TWA: 10 CEIL: 75 (ppm) from ACGIH (TLV) TWA: 40 CEIL: 300 (mg/m3) from ACGIHConsult local authorities for acceptableexposure limits.












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p. 4





Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0



Solubility:Easily soluble in methanol, diethyl ether, n-octanol, acetone. Very slightly soluble in cold water.









Polymerization: No.



Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 413 mg/kg [Mouse]. Acute dermal toxicity (LD50): 2800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):1414.2 ppm 4 hour(s) [Rat].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: Classified + (PROVEN) by OSHA. Classified 2B (Possible for human.) by IARC. Classified 2(Reasonably anticipated.) by NTP. The substance is toxic to lungs, the nervous system, liver, mucous membranes.

Other Toxic Effects on Humans:Extremely hazardous in case of ingestion. Very hazardous in case of inhalation. Hazardous in case of skin contact (irritant).


Special Remarks on Chronic Effects on Humans: Passes through the placental barrier in animal. Excreted in maternal milkin human.





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p. 5





Waste Disposal:



Identification: : Ethylene dichloride : UN1184 PG: II

Special Provisions for Transport: Marine Pollutant


Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,birth defects or other reproductive harm, which would require a warning under the statute: 1,2-Dichloroethane California prop.65: This product contains the following ingredients for which the State of California has found to cause cancer which wouldrequire a warning under the statute: 1,2-Dichloroethane Pennsylvania RTK: 1,2-Dichloroethane Massachusetts RTK: 1,2-Dichloroethane TSCA 8(b) inventory: 1,2-Dichloroethane CERCLA: Hazardous substances.: 1,2-Dichloroethane



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-1A: Material causing immediate andserious toxic effects (VERY TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). CLASS E: Corrosiveliquid.

DSCL (EEC):R11- Highly flammable. R20/22- Harmful by inhalation and if swallowed. R38- Irritating to skin. R41- Risk of serious damage toeyes. R45- May cause cancer.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0



Health: 2

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:

Page 322 of 485

p. 6

Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.




Created: 10/10/2005 08:17 PM

Last Updated: 05/21/2013 12:00 PM


Page 323 of 485

SAFETY DATA SHEETRevision Date 10-Feb-2015 Revision Number 1

1. IdentificationProduct Name (S)-(+)-2-Amino-1-butanol

Cat No. : AC158080000; AC158080010; AC158080025

Synonyms (S)-(+)-2-Amino-1-Butanol.




Label Elements

Signal WordDanger

Hazard StatementsCombustible liquidCauses severe skin burns and eye damage

Precautionary Statements




Skin Corrosion/irritation Category 1 BSerious Eye Damage/Eye Irritation

______________________________________________________________________________________________

Category 1

Page 1 / 7

Flammable liquids Category 4

Page 324 of 485

______________________________________________________________________________________________(S)-(+)-2-Amino-1-butanol Revision Date 10-Feb-2015

PreventionDo not breathe dust/fume/gas/mist/vapors/sprayWash face, hands and any exposed skin thoroughly after handlingWear protective gloves/protective clothing/eye protection/face protectionKeep away from heat/sparks/open flames/hot surfaces. - No smokingResponseImmediately call a POISON CENTER or doctor/physicianInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingSkinIF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/showerWash contaminated clothing before reuseEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIngestionIF SWALLOWED: Rinse mouth. DO NOT induce vomitingFireIn case of fire: Use CO2, dry chemical, or foam for extinctionStorageStore locked upStore in a well-ventilated place. Keep coolDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) None identified


Component CAS-No Weight %(+)-2-Amino-1-butanol 5856-62-2 > 98


Eye Contact Immediate medical attention is required. Rinse immediately with plenty of water, also underthe eyelids, for at least 15 minutes.

Skin Contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes.

Inhalation Remove from exposure, lie down. Move to fresh air. If breathing is difficult, give oxygen. Ifnot breathing, give artificial respiration. Immediate medical attention is required.

Ingestion Do not induce vomiting. Never give anything by mouth to an unconscious person. Drinkplenty of water. Call a physician immediately. Clean mouth with water. If possible drink milkafterwards.

Most important symptoms/effects Breathing difficulties. Causes burns by all exposure routes. Symptoms of overexposuremay be headache, dizziness, tiredness, nausea and vomiting: Product is a corrosivematerial. Use of gastric lavage or emesis is contraindicated. Possible perforation ofstomach or esophagus should be investigated: Ingestion causes severe swelling, severedamage to the delicate tissue and danger of perforation

Notes to Physician

______________________________________________________________________________________________

Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media

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Carbon dioxide (CO 2). Dry chemical. chemical foam.


Page 325 of 485


Flash Point 79 °C / 174.2 °FMethod - No information available



Specific Hazards Arising from the ChemicalFlammable.

Hazardous Combustion ProductsNitrogen oxides (NOx) Carbon monoxide (CO) Carbon dioxide (CO2)Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Ensure adequate ventilation. Use personal protective equipment.Environmental Precautions See Section 12 for additional ecological information.


Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder,sawdust). Keep in suitable, closed containers for disposal.

7. Handling and storageHandling Do not breathe dust. Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on

clothing. Use only in area provided with appropriate exhaust ventilation.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed. Keep awayfrom heat and sources of ignition. Corrosives area.



Health3

Flammability1

Instability0

Physical hazardsN/A

Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location.




______________________________________________________________________________________________


Page 3 / 7


Page 326 of 485


9. Physical and chemical propertiesPhysical State LiquidAppearance ColorlessOdor No information availableOdor Threshold No information availablepH No information availableMelting Point/Range -2 °C / 28.4 °FBoiling Point/Range 172 - 174 °C / 341.6 - 345.2 °FFlash Point 79 °C / 174.2 °FEvaporation Rate No information availableFlammability (solid,gas) No information availableFlammability or explosive limits


Vapor Pressure No information availableVapor Density 3.07Relative Density 0.940Solubility No information availablePartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature No information availableViscosity No information availableMolecular Formula C4 H11 N OMolecular Weight 89.14




Conditions to Avoid Incompatible products.

Incompatible Materials Acids, Metals, copper

Hazardous Decomposition Products Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2)




Product Information No acute toxicity information is available for this productComponent InformationToxicologically SynergisticProducts



Irritation No information available



Component CAS-No IARC NTP ACGIH OSHA

______________________________________________________________________________________________

Mexico(+)-2-Amino-1-butanol 5856-62-2 Not listed

Page 4 / 7

Not listed Not listed Not listed Not listed

Page 327 of 485









Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.Possible perforation of stomach or esophagus should be investigated: Ingestion causessevere swelling, severe damage to the delicate tissue and danger of perforation


Other Adverse Effects The toxicological properties have not been fully investigated.






14. Transport informationDOT Not regulatedTDG Not regulatedIATA

UN-No 2735Proper Shipping Name AMINES, LIQUID, CORROSIVE, N.O.S.*Hazard Class 8Packing Group III

IMDG/IMO UN-No 2735Proper Shipping Name AMINES, LIQUID, CORROSIVE, N.O.S.Hazard Class 8Packing Group III



Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL(+)-2-Amino-1-butanol - - - 227-475-9 - X

______________________________________________________________________________________________

X - - -

Page 5 / 7

Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.

Page 328 of 485


N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.
















______________________________________________________________________________________________


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WHMIS Hazard Class B3 Combustible liquidE Corrosive material

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Print Date 10-Feb-2015Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard


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End of SDS

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Material Safety Data SheetAluminum chloride, anhydrous MSDS


Product Name: Aluminum chloride, anhydrous

Catalog Codes: SLA1015

CAS#: 7446-70-0

RTECS: BD0525000

TSCA: TSCA 8(b) inventory: Aluminum chloride, anhydrous

CI#: Not available.

Synonym:

Chemical Name: Aluminum trichloride

Chemical Formula: AlCl3









Composition:


Aluminum chloride, anhydrous 7446-70-0 100

Toxicological Data on Ingredients: Aluminum chloride, anhydrous: ORAL (LD50): Acute: 3805 mg/kg [Mouse.].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (corrosive), ofeye contact (irritant). The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage orblindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal orrespiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking,unconsciousness or death.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolongedexposure to the substance can produce target organs damage. Repeated exposure of the eyes to a low level of dust canproduce eye irritation. Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dustcan produce varying degree of respiratory irritation or lung damage. Repeated exposure to a highly toxic material may producegeneral deterioration of health by an accumulation in one or many human organs.

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Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.




















Large Spill:Corrosive solid. Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Usewater spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance ondisposal.

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Precautions:Keep locked up.. Keep container dry. Do not ingest. Do not breathe dust. Never add water to this product. In case ofinsufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show thecontainer or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as metals.








Physical state and appearance: Solid. (Crystals solid.)







Melting Point: Sublimes.











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Incompatibility with various substances: Reactive with metals.


Special Remarks on Reactivity: Reacts violently with water especially when water is added to the product.





Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3805 mg/kg [Mouse.]. Acute toxicity of the dust (LC50): 5 8 hours [Human/30 min].

Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes.

Other Toxic Effects on Humans:Very hazardous in case of skin contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (corrosive).











Waste Disposal:



Identification: : Aluminum Chloride, Anhydrous UNNA: UN1726 PG: II


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Federal and State Regulations:Pennsylvania RTK: Aluminum chloride, anhydrous Massachusetts RTK: Aluminum chloride, anhydrous TSCA 8(b) inventory:Aluminum chloride, anhydrous



WHMIS (Canada):CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CLASS D-2A: Material causing other toxiceffects (VERY TOXIC). CLASS E: Corrosive solid.

DSCL (EEC): R36/38- Irritating to eyes and skin.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 0

Reactivity: 0



Health: 3

Flammability: 0

Reactivity: 0

Specific hazard:



References:-Material safety data sheet emitted by: la Commission de la Santé et de la Sécurité du Travail du Québec. -Hawley, G.G.. TheCondensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987.


Created: 10/09/2005 03:40 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetDiethylamine MSDS


Product Name: Diethylamine

Catalog Codes: SLD1672

CAS#: 109-89-7

RTECS: HZ8750000

TSCA: TSCA 8(b) inventory: Diethylamine


Synonym: n-Ethyl-ethanamine

Chemical Name: 2,2'-diethylamine

Chemical Formula: (CH3CH2)2NH









Composition:


Diethylamine 109-89-7 100

Toxicological Data on Ingredients: Diethylamine: ORAL (LD50): Acute: 540 mg/kg [Rat.]. DERMAL (LD50): Acute: 820 mg/kg [Rabbit.]. VAPOR (LC50): Acute: 4000 ppm 4 hour(s) [Rat.].


Potential Acute Health Effects:Extremely hazardous in case of ingestion. Very hazardous in case of eye contact (irritant). Hazardous in case of skin contact(irritant, permeator). Slightly hazardous in case of inhalation. Inflammation of the eye is characterized by redness, watering,and itching.

Potential Chronic Health Effects:Extremely hazardous in case of ingestion. Very hazardous in case of eye contact (irritant). Hazardous in case of skin contact(irritant, permeator). Slightly hazardous in case of inhalation. CARCINOGENIC EFFECTS: Classified A5 (Not suspected forhuman.) by ACGIH. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTALTOXICITY: Not available.


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Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Finish by rinsing thoroughly with running water to avoid a possible infection. Cold water may be used.










Flash Points: CLOSED CUP: Lower than -18°C (0°F). OPEN CUP: -28°C (-18.4°F) (Cleveland).


Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat, ofoxidizing materials.



Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. When heated to decomposition it emits toxicfumes.



Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of acetic acid. Finish cleaning by spreading water on the contaminatedsurface and dispose of according to local and regional authority requirements.

Large Spill:

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Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Eliminate all ignition sources. Neutralize the residue with a dilute solution of acetic acid. Be careful thatthe product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapour/spray. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes Keep away from incompatibles such as oxidizing agents, acids.

Storage:Alkalis may be stored in heavy duty gauge steel containers. Flammable materials should be stored in a separate safetystorage cabinet or room. Keep away from heat. Keep away from sources of ignition. Keep container tightly closed. Keep in acool, well-ventilated place. Ground all equipment containing material. A refrigerated room would be preferable for materialswith a flash point lower than 37.8°C (100°F).





Exposure Limits:TWA: 10 STEL: 25 (ppm) from ACGIH (TLV) TWA: 30 STEL: 75 (mg/m3) from ACGIHConsult local authorities for acceptableexposure limits.


Physical state and appearance: Liquid. (Liquid.)

Odor: Ammoniacal.



Color: Colorless.

pH (1% soln/water): 13 [Basic.]







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Dispersion Properties: See solubility in water, methanol, diethyl ether, n-octanol.

Solubility:Easily soluble in cold water, hot water. Soluble in methanol, diethyl ether, n-octanol.





Incompatibility with various substances: Reactive with oxidizing agents, acids.




Polymerization: No.


Routes of Entry: Dermal contact. Eye contact. Ingestion.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 540 mg/kg [Rat.]. Acute dermal toxicity (LD50): 820 mg/kg [Rabbit.]. Acute toxicity of the vapor (LC50): 4000ppm 4 hour(s) [Rat.].

Chronic Effects on Humans: CARCINOGENIC EFFECTS: Classified A5 (Not suspected for human.) by ACGIH.

Other Toxic Effects on Humans:Extremely hazardous in case of ingestion. Hazardous in case of skin contact (irritant, permeator). Slightly hazardous in case ofinhalation.



Special Remarks on other Toxic Effects on Humans: Material is destructive to tissue of the mucous membranes and upperrespiratory tract.






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Waste Disposal:



Identification: : Diethylamine : UN1154 PG: II



Federal and State Regulations:Pennsylvania RTK: Diethylamine Massachusetts RTK: Diethylamine TSCA 8(b) inventory: Diethylamine CERCLA: Hazardoussubstances.: Diethylamine



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-1B: Material causing immediate andserious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects (TOXIC).

DSCL (EEC):R11- Highly flammable. R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 3

Reactivity: 0



Health: 3

Flammability: 3

Reactivity: 0

Specific hazard:



References:-Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -Material safetydata sheet emitted by: la Commission de la SantÃ© et de la SÃ©curitÃ© du Travail du QuÃ©bec. -SAX, N.I. Dangerous

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Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -The Sigma-Aldrich Library of Chemical SafetyData, Edition II. -Guide de la loi et du rÃ¨glement sur le transport des marchandises dangeureuses au canada. Centre deconformitÃ© internatinal LtÃ©e. 1986.


Created: 10/11/2005 11:48 AM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetThionyl chloride MSDS


Product Name: Thionyl chloride

Catalog Codes:

CAS#: 7719-09-7

RTECS: XM5150000

TSCA: TSCA 8(b) inventory: Thionyl chloride

CI#: Not available.

Synonym: Sulfurous oxychloride; Sulfinyl chloride; Sulfurchloride oxide; Sulfurous dichloride; Thionyl dichloride

Chemical Name: Thionyl chloride

Chemical Formula: Cl2OS









Composition:


Thionyl chloride 7719-09-7 100

Toxicological Data on Ingredients: Thionyl chloride: VAPOR (LC50): Acute: 500 ppm 1 hours [Rat].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case ofskin contact (corrosive, permeator), of eye contact (corrosive). Liquid or spray mist may produce tissue damage particularlyon mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mistmay produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation ischaracterized by itching, scaling, reddening, or, occasionally, blistering.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to upper respiratory tract, skin, eyes. Repeatedor prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mistmay produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may producerespiratory tract irritation leading to frequent attacks of bronchial infection. Repeated exposure to a highly toxic material mayproduce general deterioration of health by an accumulation in one or many human organs.

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Special Remarks on Fire Hazards: When heated to decomposition it emits toxic fumes.

Special Remarks on Explosion Hazards:I t w i l l e x p l o d e i n t h e p r e s e n c e o f s e v e r a l c h e m i c a l s : A z i d o a c e t y l a c i d , C h l o r y l p e r c h lo r a t e , N,N-Dimethylformamide, Dimethyl sulfoxide and acyl halides, Hexafluoropropyplideneaminolithium, Linseed oil +quinoline, o-Nitrobenzoylacetic acid, p-Nitrobenzoyl and cold ammonia solution, o-Nitrophenylacetic acid; Sodium hydroxide,Sulfur dioxide, Toluene + ethanol+ water, water.


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Large Spill:Corrosive liquid. Poisonous liquid. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material.Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Use water sprayto reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Becareful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Keep away from direct sunlight or strongincandescent light. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. Avoid shock andfriction. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediatelyand show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as metals, acids,alkalis, moisture.




Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.


Exposure Limits:CEIL: 1 (ppm) from OSHA (PEL) [United States] CEIL: 1 from ACGIH (TLV) [United States] CEIL: 1 (ppm) from NIOSH [UnitedStates] TWA: 1 (ppm) [Denmark] STEL: 1 (ppm) [Belgium] STEL: 1 (ppm) [United Kingdom (UK)] Consult local authorities foracceptable exposure limits.


Physical state and appearance: Liquid. (Fuming liquid.)

Odor: Suffocating.



Color: Colorless to light yellow.

pH (1% soln/water): Not applicable.


Melting Point:-104.5°C (-156.1°F) Decomposition temperature: >140 deg. C



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Solubility:Insoluble in cold water. Miscible with chloroform, benzene, carbon tetrachloride




Conditions of Instability: Incompatible materials, moisture/moist air, temperatures above 140 deg. C

Incompatibility with various substances:Reactive with metals, acids, alkalis, moisture. The product may undergo hazardous decomposition, condensation orpolymerization, it may react violently with water to emit toxic gases or it may become self-reactive under conditions of shock orincrease in temperature or pressure.


Special Remarks on Reactivity:Thionyl chloride fumes on exposure to moist air. In the presence of moisture/water it decomposes and liberates toxic gasesof hydrogen chloride and sulfur dioxide. Decomposes when heated above 140 deg. C forming chlorine, sulfur dioxide, sulfurmonochloride, hydrogen chloride. Thionyl chloride decomposes in acids, alcohols, alkalies. It is also incompatible with amines,ammonia, chloryl perchlorate, dimethyl sulfoxide, hexafluoro isopropylidene amino lithium, linseed oil, quinoline, sodium,sulfinyl chloride, N,N-Dimethylformamide, metals. It reacts with Grignard reagents to form suloxides.





Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute toxicityof the vapor (LC50): 500 1 hours [Rat].

Chronic Effects on Humans: May cause damage to the following organs: upper respiratory tract, skin, eyes.

Other Toxic Effects on Humans:Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (irritant), of ingestion, .Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive).



Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Corrosive. Causes skin burns. May be absorbed through skin in harmful amounts. Eyes:Corrosive. Causes eye burns. Lachrymator. May cause conjunctivitis, corneal damage. Inhalation: Corrosive. Harmful if

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inhaled. Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema ofthe larynx and bronchi, chemical pneumonitis, and pulmonary edema. Toxic exposure to fumes of Thionyl chloride reactingwith water may result in delayed pulmonary response, bronchiolitis Oblitereans(inflammmation of the bronchioles). Ingestion:Corrosive. Harmful if swallowed. Causes gastrointestinal/digestive tract burns. May cause severe and permanent damage tothe digestive tract.











Identification: : Thionyl chloride UNNA: 1836 PG: I



Federal and State Regulations:Connecticut hazardous material survey.: Thionyl chloride Illinois toxic substances disclosure to employee act: Thionyl chlorideRhode Island RTK hazardous substances: Thionyl chloride Pennsylvania RTK: Thionyl chloride Florida: Thionyl chlorideMinnesota: Thionyl chloride Massachusetts RTK: Thionyl chloride Massachusetts spill list: Thionyl chloride New Jersey:Thionyl chloride California Director's List of Hazardous Substances: Thionyl chloride TSCA 8(b) inventory: Thionyl chloride



WHMIS (Canada):CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CLASS E: Corrosive liquid. CLASS F:Dangerously reactive material.

DSCL (EEC):

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 0

Reactivity: 2

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Personal Protection:


Health: 4

Flammability: 0

Reactivity: 2

Specific hazard:

Protective Equipment:Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.




Created: 10/10/2005 12:19 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetSodium azide MSDS


Product Name: Sodium azide

Catalog Codes: SLS1363

CAS#: 26628-22-8

RTECS: VY8050000

TSCA: TSCA 8(b) inventory: Sodium azide

CI#: Not available.

Synonym:

Chemical Name: Hydrazoic Acid, Sodium Salt

Chemical Formula: NaN3









Composition:


Sodium azide 26628-22-8 100

Toxicological Data on Ingredients: Sodium azide: ORAL (LD50): Acute: 27 mg/kg [Rat]. 27 mg/kg [Mouse]. DERMAL(LD50): Acute: 20 mg/kg [Rabbit].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant). Hazardous in case of ingestion, of inhalation.Slightly hazardous in case of skin contact (permeator). Severe over-exposure can result in death. Inflammation of the eyeis characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Notavailable. DEVELOPMENTAL TOXICITY: Not available. Repeated exposure to an highly toxic material may produce generaldeterioration of health by an accumulation in one or many human organs.


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Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.












Products of Combustion: Some metallic oxides.

Fire Hazards in Presence of Various Substances: Highly flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of static discharge: Not available. Highly explosive in presence of shocks, ofmetals.






Large Spill:Use a shovel to put the material into a convenient waste disposal container. Be careful that the product is not present at aconcentration level above TLV. Check TLV on the MSDS and with local authorities.


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Precautions:Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate theresidue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Take precautionarymeasures against electrostatic discharges. In case of insufficient ventilation, wear suitable respiratory equipment If ingested,seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes Keep away fromincompatibles such as metals.

Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate locked safety storage cabinet orroom.





Exposure Limits: TWA: 0.29 (mg/m3) from ACGIHConsult local authorities for acceptable exposure limits.









Melting Point: Decomposes.










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Solubility: Soluble in cold water.


Stability: Unstable.



Incompatibility with various substances: Extremely reactive or incompatible with metals.




Polymerization: No.



Toxicity to Animals:Acute oral toxicity (LD50): 27 mg/kg [Mouse]. Acute dermal toxicity (LD50): 20 mg/kg [Rabbit].


Other Toxic Effects on Humans:Very hazardous in case of skin contact (irritant). Hazardous in case of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).







Products of Biodegradation: Possibly hazardous short/long term degradation products are to be expected.




Waste Disposal:


DOT Classification: CLASS 6.1: Poisonous material.

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Identification: : Sodium azide : UN1867 PG: II



Federal and State Regulations:Pennsylvania RTK: Sodium azide Massachusetts RTK: Sodium azide TSCA 8(b) inventory: Sodium azide SARA302/304/311/312 extremely hazardous substances: Sodium azide SARA 313 toxic chemical notification and release reporting:Sodium azide CERCLA: Hazardous substances.: Sodium azide



WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).

DSCL (EEC):R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 1

Reactivity: 3



Health: 3

Flammability: 1

Reactivity: 3

Specific hazard:





Created: 10/11/2005 12:32 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetTriphenyl phosphine MSDS


Product Name: Triphenyl phosphine


CAS#: 603-35-0

RTECS: SZ3500000

TSCA: TSCA 8(b) inventory: Triphenyl phosphine

CI#: Not available.

Synonym:

Chemical Name: Not available.

Chemical Formula: (C6H5)3P









Composition:


Triphenyl phosphine 603-35-0 100

Toxicological Data on Ingredients: Triphenyl phosphine: ORAL (LD50): Acute: 700 mg/kg [Rat]. 1000 mg/kg [Mouse].DERMAL (LD50): Acute: 5001 mg/kg [Rabbit]. VAPOR (LC50): Acute: 1135 ppm 4 hour(s) [Rat].


Potential Acute Health Effects:Very hazardous in case of ingestion, . Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), ofinhalation (lung irritant).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to central nervous system (CNS). Repeated or prolongedexposure to the substance can produce target organs damage.



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Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with anemollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.









Flash Points: CLOSED CUP: 180°C (356°F).












Precautions:Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under afume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing In

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case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show thecontainer or the label. Avoid contact with skin and eyes Keep away from incompatibles such as oxidizing agents.

Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizingagents.


























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Polymerization: No.



Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 700 mg/kg [Rat]. Acute dermal toxicity (LD50): 5001 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 1135ppm 4 hour(s) [Rat].

Chronic Effects on Humans: The substance is toxic to central nervous system (CNS).

Other Toxic Effects on Humans:Very hazardous in case of ingestion, . Hazardous in case of skin contact (irritant, permeator), of inhalation (lung irritant).











Waste Disposal:





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Federal and State Regulations:TSCA 8(b) inventory: Triphenyl phosphine TSCA 8(a) PAIR: Triphenyl phosphine



WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).

DSCL (EEC):R20/22- Harmful by inhalation and if swallowed. R36/37/38- Irritating to eyes, respiratory system and skin.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 0

Flammability: 1

Reactivity: 0

Specific hazard:





Created: 10/10/2005 12:09 AM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetToluene MSDS


Product Name: Toluene

Catalog Codes: SLT2857, SLT3277

CAS#: 108-88-3

RTECS: XS5250000

TSCA: TSCA 8(b) inventory: Toluene

CI#: Not available.

Synonym: Toluol, Tolu-Sol; Methylbenzene; Methacide;Phenylmethane; Methylbenzol

Chemical Name: Toluene

Chemical Formula: C6-H5-CH3 or C7-H8









Composition:


Toluene 108-88-3 100

Toxicological Data on Ingredients: Toluene: ORAL (LD50): Acute: 636 mg/kg [Rat]. DERMAL (LD50): Acute: 14100 mg/kg[Rabbit]. VAPOR (LC50): Acute: 49000 mg/m 4 hours [Rat]. 440 ppm 24 hours [Mouse].


Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Notavailable. The substance may be toxic to blood, kidneys, the nervous system, liver, brain, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.


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Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.



Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.






Flash Points: CLOSED CUP: 4.4444°C (40°F). (Setaflash) OPEN CUP: 16°C (60.8°F).





Fire Fighting Media and Instructions:Flammable liquid, insoluble in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.


Special Remarks on Explosion Hazards:Toluene forms explosive reaction with 1,3-dichloro-5,5-dimethyl-2,4-imidazolididione; dinitrogen tetraoxide; concentrated nitricacid, sulfuric acid + nitric acid; N2O4; AgClO4; BrF3; Uranium hexafluoride; sulfur dichloride. Also forms an explosive mixturewith tetranitromethane.



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Large Spill:Toxic flammable liquid, insoluble or very slightly soluble in water. Keep away from heat. Keep away from sources of ignition.Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container.Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance ondisposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with localauthorities.


Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents.






Exposure Limits:TWA: 200 STEL: 500 CEIL: 300 (ppm) from OSHA (PEL) [United States] TWA: 50 (ppm) from ACGIH (TLV) [United States]SKIN TWA: 100 STEL: 150 from NIOSH [United States] TWA: 375 STEL: 560 (mg/m3) from NIOSH [United States] Consultlocal authorities for acceptable exposure limits.



Odor: Sweet, pungent, Benzene-like.



Color: Colorless.

pH (1% soln/water): Not applicable.



Critical Temperature: 318.6°C (605.5°F)


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Solubility:Soluble in diethyl ether, acetone. Practically insoluble in cold water. Soluble in ethanol, benzene, chloroform, glacial aceticacid, carbon disulfide. Solubility in water: 0.561 g/l @ 25 deg. C.




Conditions of Instability: Heat, ignition sources (flames, sparks, static), incompatible materials



Special Remarks on Reactivity:Incompatible with strong oxidizers, silver perchlorate, sodium difluoride, Tetranitromethane, Uranium Hexafluoride. FrozenBromine Trifluoride reacts violently with Toluene at -80 deg. C. Reacts chemically with nitrogen oxides, or halogens to formnitrotoluene, nitrobenzene, and nitrophenol and halogenated products, respectively.






Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.May cause damage to the following organs: blood, kidneys, the nervous system, liver, brain, central nervous system (CNS).

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).

Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LDL [Human] - Route: Oral; Dose: 50 mg/kg LCL [Rabbit] - Route: Inhalation; Dose: 55000ppm/40min

Special Remarks on Chronic Effects on Humans:Detected in maternal milk in human. Passes through the placental barrier in human. Embryotoxic and/or foetotoxic in animal.May cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material (mutagenic)

Special Remarks on other Toxic Effects on Humans:

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Acute Potential Health Effects: Skin: Causes mild to moderate skin irritation. It can be absorbed to some extent throughthe skin. Eyes: Cauess mild to moderate eye irritation with a burning sensation. Splash contact with eyes also causesconjunctivitis, blepharospasm, corneal edema, corneal abraisons. This usually resolves in 2 days. Inhalation: Inhalationof vapor may cause respiratory tract irritation causing coughing and wheezing, and nasal discharge. Inhalation of highconcentrations may affect behavior and cause central nervous system effects characterized by nausea, headache, dizziness,tremors, restlessness, lightheadedness, exhilaration, memory loss, insomnia, impaired reaction time, drowsiness, ataxia,hallucinations, somnolence, muscle contraction or spasticity, unconsciousness and coma. Inhalation of high concentration ofvapor may also affect the cardiovascular system (rapid heart beat, heart palpitations, increased or decreased blood pressure,dysrhythmia, ), respiration (acute pulmonary edema, respiratory depression, apnea, asphyxia), cause vision disturbancesand dilated pupils, and cause loss of appetite. Ingestion: Aspiration hazard. Aspiration of Toluene into the lungs may causechemical pneumonitis. May cause irritation of the digestive tract with nausea, vomiting, pain. May have effects similar to thatof acute inhalation. Chronic Potential Health Effects: Inhalation and Ingestion: Prolonged or repeated exposure via inhalationmay cause central nervous system and cardiovascular symptoms similar to that of acute inhalation and ingestion as well liverdamage/failure, kidney damage/failure (with hematuria, proteinuria, oliguria, renal tubular acidosis), brain damage, weightloss, blood (pigmented or nucleated red blood cells, changes in white blood cell count), bone marrow changes, electrolyteimbalances (Hypokalemia, Hypophostatemia), severe, muscle weakness and Rhabdomyolysis. Skin: Repeated or prolongedskin contact may cause defatting dermatitis.


Ecotoxicity:Ecotoxicity in water (LC50): 313 mg/l 48 hours [Daphnia (daphnia)]. 17 mg/l 24 hours [Fish (Blue Gill)]. 13 mg/l 96 hours [Fish(Blue Gill)]. 56 mg/l 24 hours [Fish (Fathead minnow)]. 34 mg/l 96 hours [Fish (Fathead minnow)]. 56.8 ppm any hours [Fish(Goldfish)].









Identification: : Toluene UNNA: 1294 PG: II



Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,birth defects or other reproductive harm, which would require a warning under the statute: Toluene California prop. 65 (nosignificant risk level): Toluene: 7 mg/day (value) California prop. 65 (acceptable daily intake level): Toluene: 7 mg/day (value)California prop. 65: This product contains the following ingredients for which the State of California has found to cause birthdefects which would require a warning under the statute: Toluene Connecticut hazardous material survey.: Toluene Illinois

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toxic substances disclosure to employee act: Toluene Illinois chemical safety act: Toluene New York release reporting list:Toluene Rhode Island RTK hazardous substances: Toluene Pennsylvania RTK: Toluene Florida: Toluene Minnesota: TolueneMichigan critical material: Toluene Massachusetts RTK: Toluene Massachusetts spill list: Toluene New Jersey: Toluene NewJersey spill list: Toluene Louisiana spill reporting: Toluene California Director's List of Hazardous Substances.: Toluene TSCA8(b) inventory: Toluene TSCA 8(d) H and S data reporting: Toluene: Effective date: 10/04/82; Sunset Date: 10/0/92 SARA 313toxic chemical notification and release reporting: Toluene CERCLA: Hazardous substances.: Toluene: 1000 lbs. (453.6 kg)



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC).

DSCL (EEC):R11- Highly flammable. R20- Harmful by inhalation. S16- Keep away from sources of ignition - No smoking. S25- Avoidcontact with eyes. S29- Do not empty into drains. S33- Take precautionary measures against static discharges.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0



Health: 2

Flammability: 3

Reactivity: 0

Specific hazard:





Created: 10/10/2005 08:30 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetN,N-Dimethylformamide MSDS


Product Name: N,N-Dimethylformamide


CAS#: 68-12-2

RTECS: LQ2100000

TSCA: TSCA 8(b) inventory: N,N-Dimethylformamide


Synonym: DMF; Dimethyl Formamide

Chemical Name: N,N-Dimethylformamide

Chemical Formula: HCON(CH3)2









Composition:


{N,N-}Dimethylformamide 68-12-2 100

Toxicological Data on Ingredients: N,N-Dimethylformamide: ORAL (LD50): Acute: 2800 mg/kg [Rat]. 2900 mg/kg [Mouse].5000 mg/kg [Rabbit]. DERMAL (LD50): Acute: 4720 mg/kg [Rabbit].


Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion,of inhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammaliansomatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified POSSIBLE for human.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE].The substance is toxic to kidneys, liver, central nervous system (CNS). The substance may be toxic to blood, the nervoussystem. Repeated or prolonged exposure to the substance can produce target organs damage.


Eye Contact:

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Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.




Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.






Flash Points: CLOSED CUP: 57.778°C (136°F). (Tagliabue.) OPEN CUP: 67°C (152.6°F).







Special Remarks on Explosion Hazards:A mixture of triethylaluminum and DMF explodes when heated. DMF + potassium permanganate may explode.



Large Spill:

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Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.


Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids.






Exposure Limits:TWA: 10 (ppm) from ACGIH (TLV) [United States] TWA: 30 (mg/m3) from ACGIH (TLV) [United States] Consult localauthorities for acceptable exposure limits.



Odor: Amine like. (Slight.)



Color: Colorless to light yellow.




Critical Temperature: 374°C (705.2°F)





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Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -1



Solubility:Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible organic solvents. Soluble in benzene, andchloroform.




Conditions of Instability: Heat, ignition sources (sparks, flames), incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, acids.


Special Remarks on Reactivity:Can react vigorously with oxidizing agents, halogenated hydrocarbons, and inorganic nitrates. Incompatible with carbontetrachloride, alkyl aluminums, sodium tetrahydroborate, nitrates, chromic acid, diisocyanatomethane, triethylaluminum,sodium hydride, lithium azide, metallic sodium, bromine, magnesium nitrate, potassium permanganate, nitric acid, chromiumtrioxide, borohydrides, phosphorus trioxide, diborane, octafluoroisobutyrate, sodium nitrite, perchloryl fluoride, postassiummethyl 4,4'-dinitrobutyrate. Reaction with inorganic acid chlorides, such as phosphorous oxychloride and thionyl chloride, mayform dimethylcarbamoyl, a suspect carcinogen. May release dimethylamine and carbon monoixde if heated above 350 C (662F).

Special Remarks on Corrosivity:Pure dimethylformamide is essentially non-corrosive to metals. However copper, tin and their alloys should be avoided.





Chronic Effects on Humans:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammaliansomatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified POSSIBLE for human.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE].Causes damage to the following organs: kidneys, liver, central nervous system (CNS). May cause damage to the followingorgans: blood, the nervous system.

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LCL[Rat] - Route: Inhalation; Dose: 5000 ppm/6H

Special Remarks on Chronic Effects on Humans:May affect genetic material. May cause adverse reproductive effects(paternal and maternal) and birth defects. Embryotoxicand/or foetotoxic in animal. Passes through the placental barrier in animal. May cause cancer although IARC evidence forcancer in humans shows inadequate data.

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Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation with itching, burning, redness, swelling, or rash. It may be absorbedthrough the skin in toxic amounts and cause systemic effects similar to that of ingestion. It may facilitate the absorptionof other chemical substances through the skin. If there is significant potential for skin contact, monitoring should be doneto measure the level of DMF metabolites in urine specimans at the end of the shift. It is common practice to limit end-of-shift metabolites at or below 40 ppm expressed as n-monomethylformamide or a single individual or at or below 20 ppmMMF for several workers doing the same job. Eyes: Causes eye irritation (possibly severe) with tearing pain or blurredvision. Inhalation: May cause respiratory tract irritation. Short-term overexposure by inhalation may affect behavior/centralnervous system (convulsions, muscle weakness and other symptoms similar to that of acute ingestion), respiration (dyspnea).Ingestion: It can cause gastrointestinal tract irritation with heartburn, abdominal pain, nausea, vomiting or diarrhea. It may alsoaffect the cardiovascular system (hypertension, tachycardia, ECG abnormalities), blood (elevated white blood cell counts), andliver damage (hepatomegaly, jaundice, altered liver enzymes, fatty liver











Identification: : N,N-Dimethylformamide UNNA: 2265 PG: III



Federal and State Regulations:Illinois toxic substances disclosure to employee act: N,N-Dimethylformamide Illinois chemical safety act: N,N-Dimethylformamide New York release reporting list: N,N-Dimethylformamide Rhode Island RTK hazardous substances: N,N-Dimethylformamide Pennsylvania RTK: N,N-Dimethylformamide Minnesota: N,N-Dimethylformamide Massachusetts RTK:N,N-Dimethylformamide Massachusetts spill list: N,N-Dimethylformamide New Jersey: N,N-Dimethylformamide New Jerseyspill list: N,N-Dimethylformamide Louisiana spill reporting: N,N-Dimethylformamide California Director's List of HazardousSubstances: N,N-Dimethylformamide TSCA 8(b) inventory: N,N-Dimethylformamide TSCA 8(d) H and S data reporting: N,N-Dimethylformamide: 12/19/95 SARA 313 toxic chemical notification and release reporting: N,N-Dimethylformamide CERCLA:Hazardous substances.: N,N-Dimethylformamide: 100 lbs. (45.36 kg)



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WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS D-2A: Material causingother toxic effects (VERY TOXIC).

DSCL (EEC):R20/21- Harmful by inhalation and in contact with skin. R36- Irritating to eyes. R61- May cause harm to the unborn child.S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S53- Avoidexposure - obtain special instructions before use.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 2

Reactivity: 0



Health: 1

Flammability: 2

Reactivity: 0

Specific hazard:





Created: 10/09/2005 05:12 PM

Last Updated: 05/21/2013 12:00 PM


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SAFETY DATA SHEETCreation Date 21-Oct-2009 Revision Date 12-May-2014 Revision Number 1

1. IdentificationProduct Name Hexamethylenetetramine

Cat No. : H288-500, H290-500

Synonyms HMTA; Hexamine; Methenamine




Label Elements

Signal WordWarning

Hazard StatementsFlammable solidMay cause an allergic skin reaction



Skin Sensitization Category 1

______________________________________________________________________________________________

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Flammable solids Category 2

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______________________________________________________________________________________________Hexamethylenetetramine Revision Date 12-May-2014

Precautionary StatementsPreventionAvoid breathing dust/fume/gas/mist/vapors/sprayContaminated work clothing should not be allowed out of the workplaceKeep away from heat/sparks/open flames/hot surfaces. - No smokingGround/bond container and receiving equipmentUse explosion-proof electrical/ventilating/lighting/equipmentWear protective gloves/protective clothing/eye protection/face protectionSkinIF ON SKIN: Wash with plenty of soap and waterIf skin irritation or rash occurs: Get medical advice/attentionWash contaminated clothing before reuseFireIn case of fire: Use CO2, dry chemical, or foam for extinctionDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) May form combustible dust concentrations in air


Component CAS-No Weight %Methenamine 100-97-0 >95



Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Get medical attention immediately ifsymptoms occur.


Most important symptoms/effects May cause allergic skin reaction. Symptoms of allergic reaction may include rash, itching,swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chestpain, muscle pain or flushing


5. Fire-fighting measuresSuitable Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Cool closed

containers exposed to fire with water spray.


Flash Point 250 °C / 482 °F

Method - No information available

Autoignition Temperature 400 °C / 752 °F

Explosion LimitsUpper No data availableLower No data availableSensitivity to Mechanical Impact No information availableSensitivity to Static Discharge No information available

Specific Hazards Arising from the ChemicalFlammable. Containers may explode when heated. Dust can form an explosive mixture in air.

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Hazardous Combustion ProductsCarbon monoxide (CO) Carbon dioxide (CO 2) Nitrogen oxides (NOx) Ammonia FormaldehydeProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Use personal protective equipment. Avoid dust formation. Remove all sources of ignition.

Take precautionary measures against static discharges.Environmental Precautions Should not be released into the environment. See Section 12 for additional ecological

Information.


Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dustformation. Remove all sources of ignition. Use spark-proof tools and explosion-proofequipment.

7. Handling and storageHandling Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid

ingestion and inhalation. Avoid dust formation. Keep away from open flames, hot surfacesand sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Takeprecautionary measures against static discharges.

Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Flammables area.Keep away from heat and sources of ignition.

8. Exposure controls / personal protectionExposure Guidelines


Methenamine 100-97-0 ( >95 )

STEL: 0.35 ppmSTEL: 2 mg/m3

Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location.Ensure adequate ventilation, especially in confined areas. Use explosion-proofelectrical/ventilating/lighting/equipment.






9. Physical and chemical propertiesPhysical State SolidAppearance WhiteOdor OdorlessOdor Threshold No information availablepH 8.5 - 9.5 10% aq. solutionMelting Point/Range No data availableBoiling Point/Range No information available

Health2

Flammability2

Instability1

Physical hazardsN/A

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Flash Point 250 °C / 482 °FEvaporation Rate Not applicableFlammability (solid,gas) No information availableFlammability or explosive limits


Vapor Pressure 0.0035 hPa @ 20 °CVapor Density Not applicableRelative Density 1.330Solubility Soluble in waterPartition coefficient; n-octanol/water No data availableAutoignition Temperature 400 °C / 752 °FDecomposition temperature 260 (sublimation) °CViscosity Not applicableMolecular Formula C6 H12 N4Molecular Weight 140.19



Stability Stable under normal conditions. Moisture sensitive.

Conditions to Avoid Avoid dust formation. Keep away from open flames, hot surfaces and sources of ignition.Incompatible products. Excess heat. Exposure to moisture.

Incompatible Materials Strong oxidizing agents, Strong acids

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO 2), Nitrogen oxides (NOx), Ammonia,Formaldehyde

Hazardous Polymerization No information available.



Product InformationComponent Information

Component LD50 Oral LD50 Dermal LC50 InhalationMethenamine 9200 mg/kg ( Rat ) Not listed Not listed




Irritation No information available

Sensitization May cause sensitization by skin contact


Component CAS-No IARC NTP ACGIH OSHA MexicoMethenamine 100-97-0 Not listed Not listed Not listed Not listed Not listed






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Symptoms / effects,both acute and delayed

Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tinglingof the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing


Other Adverse Effects See actual entry in RTECS for complete information.

12. Ecological informationEcotoxicity .

Component Freshwater Algae Freshwater Fish Microtox Water FleaMethenamine Not listed Pimephales promelas:

EC50=49.8 g/L/96hNot listed EC50 = 36 g/L/48h

Persistence and Degradability Soluble in water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its water solubility.

Component log PowMethenamine -2.2




UN-No UN1328Proper Shipping Name HEXAMETHYLENETETRAMINEHazard Class 4.1Packing Group III

TDG UN-No UN1328Proper Shipping Name HEXAMETHYLENETETRAMINEHazard Class 4.1Packing Group III

IATA UN-No UN1328Proper Shipping Name HexamethylenetetramineHazard Class 4.1Packing Group III

IMDG/IMO UN-No UN1328Proper Shipping Name HexamethylenetetramineHazard Class 4.1Packing Group III


International InventoriesComponent TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLMethenamine X X - 202-905-8 - X X X X X

Legend:

X - Listed

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E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.

F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.

N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to coverthe designated polymer made with any free-radical initiator regardless of the amount used.

P - Indicates a commenced PMN substance

R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.

S - Indicates a substance that is identified in a proposed or final Significant New Use Rule

T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.

XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCAInventory Data Base Production and Site Reports (40 CFR 710(B).

Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.

Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of lowconcern reactants that comprises one of the eligibility criteria for the exemption rule.










State Right-to-Know

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Methenamine - X - - -





Mexico - Grade Slight risk, Grade 1

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WHMIS Hazard Class B4 Flammable solidD2B Toxic materials



Creation Date 21-Oct-2009Revision Date 12-May-2014Print Date 12-May-2014Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard



End of SDS

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Material Safety Data SheetHippuric acid MSDS


Product Name: Hippuric acid

Catalog Codes: SLH1774

CAS#: 495-69-2

RTECS: MR8150000

TSCA: TSCA 8(b) inventory: Hippuric acid

CI#: Not available.

Synonym: N-Benzoylglycine

Chemical Formula: C9H9NO3









Composition:


Hippuric acid 495-69-2 100

Toxicological Data on Ingredients: Hippuric acid LD50: Not available. LC50: Not available.


Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.





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Precautions:Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue undera fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing In case ofinsufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label whenpossible. Avoid contact with skin and eyes

Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizingagents.

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Polymerization: No.





Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation.











Waste Disposal:






Federal and State Regulations: TSCA 8(b) inventory: Hippuric acid

Other Regulations: Not available..



DSCL (EEC): R36/38- Irritating to eyes and skin.

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HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.




Created: 10/09/2005 05:44 PM

Last Updated: 05/21/2013 12:00 PM


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Material Safety Data SheetFumaric acid MSDS


Product Name: Fumaric acid

Catalog Codes: SLF1987, SLF1186

CAS#: 110-17-8

RTECS: LS9625000

TSCA: TSCA 8(b) inventory: Fumaric acid

CI#: Not available.

Synonym: 2-Butenedioic acid

Chemical Formula: C4H4O4









Composition:


Fumaric acid 110-17-8 100

Toxicological Data on Ingredients: Fumaric acid: ORAL (LD50): Acute: 10700 mg/kg [Rat]. DERMAL (LD50): Acute: 20000mg/kg [Rabbit].


Potential Acute Health Effects:Hazardous in case of eye contact (irritant), of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), ofinhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolongedexposure to the substance can produce target organs damage.


Eye Contact:

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Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.




















Large Spill: Use a shovel to put the material into a convenient waste disposal container.


Precautions:Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue undera fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Avoid contact with eyes Wearsuitable protective clothing If ingested, seek medical advice immediately and show the container or the label.

Storage:

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Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizingagents.














Melting Point: Sublimes. (200°C or 392°F)










Solubility: Very slightly soluble in cold water.




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p. 4






Polymerization: No.


Routes of Entry: Eye contact. Ingestion.

Toxicity to Animals:Acute oral toxicity (LD50): 10700 mg/kg [Rat]. Acute dermal toxicity (LD50): 20000 mg/kg [Rabbit].

Chronic Effects on Humans: The substance is toxic to lungs, mucous membranes.

Other Toxic Effects on Humans:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), of inhalation.











Waste Disposal:



Identification: : Not available. : NA9126 PG: III



Federal and State Regulations:

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p. 5

Pennsylvania RTK: Fumaric acid Massachusetts RTK: Fumaric acid TSCA 8(b) inventory: Fumaric acid CERCLA: Hazardoussubstances.: Fumaric acid



WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

DSCL (EEC): R36- Irritating to eyes.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:





Created: 10/10/2005 08:19 PM

Last Updated: 05/21/2013 12:00 PM


Page 386 of 485

p. 1

3 3 2

He a lt h

Fire

Re a c t iv it y


3

3

2

Material Safety Data SheetAcetyl chloride MSDS


Product Name: Acetyl chloride

Catalog Codes: SLA4552

CAS#: 75-36-5

RTECS: AO6390000

TSCA: TSCA 8(b) inventory: Acetyl chloride


Synonym: Ethanoyl chloride

Chemical Name: Acethyl chloride

Chemical Formula: CH3COCl









Composition:


Acetyl chloride 75-36-5 100

Toxicological Data on Ingredients: Acetyl chloride: ORAL (LD50): Acute: 910 mg/kg [Rat].


Potential Acute Health Effects:Very hazardous in case of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (irritant,permeator). Corrosive to skin and eyes on contact. Liquid or spray mist may produce tissue damage particularly on mucousmembranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may producesevere irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye ischaracterized by redness, watering, and itching.

Potential Chronic Health Effects:Very hazardous in case of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (irritant,permeator). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS:Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeatedor prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mistmay produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may producerespiratory tract irritation leading to frequent attacks of bronchial infection.

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p. 2



Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.








Auto-Ignition Temperature: 732.7 (1350.9°F)

Flash Points: CLOSED CUP: 4.4°C (39.9°F).

Flammable Limits: LOWER: 7.3%


Fire Hazards in Presence of Various Substances: Highly flammable in presence of moisture.


Fire Fighting Media and Instructions:Moisture reactive material. Flammable liquid. SMALL FIRE: Obtain advice on use of water. Use DRY chemical powder.LARGE FIRE: Use alcohol foam, water spray or fog. Do not use water jet.





Large Spill:

Page 388 of 485

p. 3

Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorbwith DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material.Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call forassistance on disposal.


Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material.Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, alkalis, moisture.




Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.




Physical state and appearance: Liquid. (Fuming liquid.)

Odor: Strong.



Color: Colorless.






Vapor Pressure: 32 kPa (@ 20°C)




Page 389 of 485

p. 4



Dispersion Properties: See solubility in water, diethyl ether.

Solubility: Soluble in diethyl ether.





Incompatibility with various substances: Reactive with oxidizing agents, alkalis, moisture.


Special Remarks on Reactivity: Reacts violently with alcohol.

Special Remarks on Corrosivity: Corrosive.



Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.


Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes.

Other Toxic Effects on Humans:Very hazardous in case of ingestion, of inhalation. Hazardous in case of skin contact (irritant, permeator).



Special Remarks on other Toxic Effects on Humans: Material is irritating to mucous membranes and upper respiratorytract.








Waste Disposal:

Page 390 of 485

p. 5



Identification: : Acetyl Chloride UNNA: UN1717 PG: II



Federal and State Regulations:Pennsylvania RTK: Acetyl chloride Massachusetts RTK: Acetyl chloride TSCA 8(b) inventory: Acetyl chloride CERCLA:Hazardous substances.: Acetyl chloride



WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC). CLASS E: Corrosive liquid.

DSCL (EEC):R11- Highly flammable. R22- Harmful if swallowed. R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 3

Reactivity: 2

Personal Protection:


Health: 3

Flammability: 3

Reactivity: 2

Specific hazard:

Protective Equipment:Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.


References:-Guide de la loi et du rÃ¨glement sur le transport des marchandises dangeureuses au canada. Centre de conformitÃ©internatinal LtÃ©e. 1986. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van NostrandReinold, 1987. -SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -TheSigma-Aldrich Library of Chemical Safety Data, Edition II.


Created: 10/11/2005 11:12 AM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

Page 391 of 485

p. 6

no liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

Page 392 of 485

Sigma - SML0089 Page 1 of 6




1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifiers Product name : Abacavir sulfate

Product Number : SML0089 Brand : Sigma CAS-No. : 188062-50-2




Company : Sigma-Aldrich Chemicals Pvt Limited Plot No 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

Telephone : +91 80-6621 9400 Fax : +91 80-6621 9450


Emergency Phone # :

2. HAZARDS IDENTIFICATION


Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Carcinogenicity (Category 2) Reproductive toxicity (Category 2)

Classification according to EU Directives 67/548/EEC or 1999/45/EC Limited evidence of a carcinogenic effect. Possible risk of harm to the unborn child.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram

Signal word Warning Hazard statement(s) H351 Suspected of causing cancer. H361 Suspected of damaging fertility or the unborn child. Precautionary statement(s) P281 Use personal protective equipment as required. Supplemental Hazard Statements

none

According to European Directive 67/548/EEC as amended. Hazard symbol(s)

Page 393 of 485

LenovoLap

Typewritten text

Annexure- 10


R-phrase(s) R40 Limited evidence of a carcinogenic effect. R63 Possible risk of harm to the unborn child. S-phrase(s) S36/37 Wear suitable protective clothing and gloves.

2.3 Other hazards - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances Synonyms : Abacavir hemisulfate

Formula : C14H18N6O · 0.5 H2SO4

Molecular Weight : 335,37 g/mol Component Concentration

Abacavir sulfate

CAS-No.

188062-50-2

-








4.2 Most important symptoms and effects, both acute and delayed Hypersensitivity reactions include:, Fever, Rash, Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea., Fatigue, Respiratory disorder

4.3 Indication of any immediate medical attention and special treatment needed no data available

5. FIREFIGHTING MEASURES



5.2 Special hazards arising from the substance or mixture no data available

5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary.

5.4 Further information no data available

Page 394 of 485



6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.





7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.



7.3 Specific end uses no data available

8. EXPOSURE CONTROLS/PERSONAL PROTECTION


Components with workplace control parameters




Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Page 395 of 485




a) Appearance Form: solid

b) Odour no data available

c) Odour Threshold no data available

d) pH no data available


no data available


no data available

g) Flash point no data available

h) Evaporation rate no data available

i) Flammability (solid, gas) no data available


no data available

k) Vapour pressure no data available

l) Vapour density no data available

m) Relative density no data available

n) Water solubility no data available


no data available

p) Autoignition temperature

no data available


no data available

r) Viscosity no data available

s) Explosive properties no data available

t) Oxidizing properties no data available

9.2 Other safety information no data available


10.1 Reactivity no data available

10.2 Chemical stability no data available

10.3 Possibility of hazardous reactions no data available

10.4 Conditions to avoid no data available

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - no data available

Page 396 of 485




Acute toxicity no data available

Skin corrosion/irritation no data available

Serious eye damage/eye irritation no data available

Respiratory or skin sensitization no data available

Germ cell mutagenicity no data available

Carcinogenicity

Limited evidence of carcinogenicity in animal studies



Suspected human reproductive toxicant

Specific target organ toxicity - single exposure no data available

Specific target organ toxicity - repeated exposure no data available

Aspiration hazard no data available

Potential health effects

Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation.

Signs and Symptoms of Exposure Hypersensitivity reactions include:, Fever, Rash, Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea., Fatigue, Respiratory disorder

Additional Information RTECS: Not available


12.1 Toxicity no data available

12.2 Persistence and degradability no data available

12.3 Bioaccumulative potential no data available

12.4 Mobility in soil no data available

12.5 Results of PBT and vPvB assessment no data available

Page 397 of 485


12.6 Other adverse effects no data available



Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.








14.6 Special precautions for user no data available


This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available

15.2 Chemical Safety Assessment no data available

16. OTHER INFORMATION


Page 398 of 485

- 1 -

MICRO LABS LIMITEDAPI- R&D (ML-15) BOMMASANDRA

BANGALORE


Page 1 of 3

Product identification/ Manufacture

1. Product Name : Azilsartan medoxomil potassium

Chemical Name : (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-

ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-

oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-

benzimidazole-7-carboxylate potassium

Molecular formula : C30H23KN4O8

Molecular weight : 606.62

CAS No : 175131-60-9

Manufacturer : Micro labs.Ltd

2. Product information :

Purity % 99.5-100

Melting range(0C) : 196(dec)

Boiling point : NA

Solubility : Soluble in methanol

Flammability : NDA

3. Hazard identification

Handling : Avoid formation of dust and aerosols. Provide

appropriate exhaust ventilation at places where

dust is formed .normal measurers for preventive

fire protection

4. First aid measures

Inhalation : May be harmful if inhaled. May cause

respiratory tract irritation.

Ingestion : Harmful if swallowed.

Skin contact : May be harmful if absorbed through skin. May

cause skin irritation.

Page 399 of 485

- 2 -


BANGALORE


Page 2 of 3

Eye contact : May cause eye irritation.

5. Fire-fighting measures

Extinguishing media : Use water spray, alcohol resistant foam, dry

chemical powder or carbon dioxide.

Dangerous fumes in case of fire : Oxides of carbon and Nitrogen

Fire to be fought with breathing apparatus and

protective suit.

6. Accidental release measure

Containment : Adequate ventilation to be ensured and the split

material to be shoveled using sand into

containers of disposal

7. Storage : Store in cool place. Keep container tightly closed

in dry and well ventilated place.

Recommended storage temperature: 15-30°C.

8. Exposure control/

personal protection

: Adequate safety gears like aprons, hand gloves,

eye googol’s to be worn

9.Physical / chemical data

Form : Solid

Color : Off white to white solid.

Odor : Odorless


Conditions to avoid : Exposure to high temperature and pressure.

Direct exposure to sun light

Source of ignition

Other wise stable under normal storage

conditions

11. Toxicological information : NDA

12. Ecological information : Should not be discarded along with general

Page 400 of 485

- 3 -


BANGALORE


Page 3 of 3

waste/ garbage.

Specific ecological impact information not

available.

13. Disposal

:

Waste material should be incinerated under

controlled conditions

14. Transport information : To be packed in double-lined polythene food

grade bags and further packed in HDPE / fiber

board containers.

15. Regulatory information : General health, safety and environmental

precautions to be followed.

16. Other information : NA

The information contained in this MSDS is believed to be true and correct. However, the

accuracy and corrplentencess of the information provided are with out warranty or guarantee. It

is the responsibility of user to determine the conditions for safe use of the product.

Page 401 of 485

Sigma - C1493 Page 1 of 7





1.1 Product identifiers Product name : Cilnidipine

Product Number : C1493 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 132203-70-4









Classification according to Regulation (EC) No 1272/2008 Serious eye damage (Category 1), H318


2.2 Label elements


Signal word Danger Hazard statement(s) H318 Causes serious eye damage. Precautionary statement(s) P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard none

Page 402 of 485


Statements



3.1 Substances Synonyms : 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

2-methoxyethyl (2E)-3-phenyl-2-propenyl ester FRC 8653

Formula : C27H28N2O7

Molecular weight : 492.52 g/mol CAS-No. : 132203-70-4 Hazardous ingredients according to Regulation (EC) No 1272/2008


Cilnidipine

CAS-No.

132203-70-4

Eye Dam. 1; H318 <= 100 %

















Page 403 of 485








7.1 Precautions for safe handling Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2.


Light sensitive. Storage class (TRGS 510): Combustible Solids








Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators

Page 404 of 485


and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).




a) Appearance Form: powder Colour: light yellow





No data available


No data available

g) Flash point No data available




No data available






No data available


No data available


No data available









Page 405 of 485


10.4 Conditions to avoid Exposure to light may affect product quality.


10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 4,412 mg/kg(Cilnidipine) Remarks: Skin and Appendages: Other: Hair.

Skin corrosion/irritation No data available(Cilnidipine)

Serious eye damage/eye irritation No data available(Cilnidipine)

Respiratory or skin sensitisation No data available(Cilnidipine)

Germ cell mutagenicity No data available(Cilnidipine)

Carcinogenicity



Specific target organ toxicity - single exposure No data available(Cilnidipine)


Aspiration hazard No data available(Cilnidipine)

Additional Information RTECS: US7975550 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Cilnidipine)





Page 406 of 485


12.4 Mobility in soil No data available(Cilnidipine)

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted




Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.














H318 Causes serious eye damage.


Page 407 of 485


Page 408 of 485

Page 1 of 3

MICRO LABS LTD

API, BOMMASANDRA (ML-15)

Material Safety Data Sheet

1.Product identification/Manufacture

Name : Cyamemazine

Chemical Name :10-(3-dimethylamino-2-methyl-propyl)phenothiazine-2-carbonitrile

Molecular Formula : C19H21N3S

Molecular Weight : 323.46 g/mol

CAS No : 3546-03-0

Manufacturer :

Micro labs ltd.Plot No.43-45,4thphase,KIADB,Jigani-Bommasandra link road,Bangalore-560105, India.Tel.No:91-8110-415647,415648

2.Product Information :

Boling point : --

Solubility : Soluble in DMSO and Methanol

Flammability : No data available

3.Hazard identification :

Handling :

As a general rule, when handling USPreference standards, avoid all contact andinhalation of dust, mists, and/or vapoursassociated with the material. Wash thoroughlyafter handling.

4.First aid measure :

Inhalation : May cause irritation. Remove to fresh air.

Ingestion :May cause irritation. Flush out mouth withwater.

Skin contact :May cause irritation. Flush with copiousquantities of water.

Page 409 of 485

Page 2 of 3

Eye contact :May cause irritation. Avoid contact. Flushwith copious quantities of water. This materialis absorbed through the eye.

5.Fire-fighting measures :

Extinguishing media :Water spray, Dry chemical, carbon dioxide, orfoam as appropriate for surrounding fire andmaterials.

Dangerous fumes in case of fire :

This material assumed to be combustible. Aswith all dry powders, it is advisable to groundmechanical equipment in contact with drymaterial to dissipate the potential buildup ofstatic electricity.As with all fires, evacuate personnel to safearea. Firefighters should use self-containedbreathing equipment and protective clothing.

6.Accidental release measure :

Containment :

Wear approved respiratory protection,chemically compatible gloves, and protectiveclothing. Wipe up spillage or collect spillageusing a high – efficiency vacuum cleaner.Avoid breathing dust. Place spillage inappropriately labeled container for disposal.Wash spill site.

7.Storage :

Store in a tight container as defined in theUSP-NF. This material should be handled andstored per label instructions to ensure productintegrity. Store in a freezer.

8.Exposure control/Personal protection :

Engineering controls such as exhaustventilation are recommended.Adequate safety wears like glasses, gloves,clothing, and respirators.

9.Physical/chemical Data :

Form : Solid

Color : White to off white

Odor : No data available

10.Stability and Reactivity :

Page 410 of 485

Page 3 of 3

Conditions to avoid :

Avoid exposure to heat.When heated to decomposition, material emitstoxic fumes. Emits toxic fumes under freeconditions.

11.Toxicological information : No data available

12.Ecological information : No data available

13.Disposal :Dispose of waste in accordance with allapplicable federal, state, and local laws.

14.Transport information : NA

15.Regulatory information : NA

16.Other information : NA

The information contained in this MSDS is believed to be true and correct. However, the accuracy andcompleteness of the information provided are with out warrenty or guarantee. It is the responsibility ofuser to determine the conditions for safe use of the product.

Page 411 of 485

Worldwide Helpline :+1.347.960.3608For further enquiries :[email protected] an online quote : click here

- MATERIAL SAFETY DATA SHEET -

SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

MSDS Name : DABIGATRAN ETEXILATE MESYLATE

Company Identification : Clearsynth Labs Pvt. Ltd. 413 Laxmi Mall, New Link Road, Andheri (W),

Mumbai-400 053, INDIAFor information call : ++91-22-26355700For emergencies call : ++91-22-26355699For further enquiries : [email protected] SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS# Chemical Name % EINECS# Haz

SymbolsRISKPHRASES

872728-81-9 DABIGATRAN ETEXILATEMESYLATE

>95% - - -

Hazard Symbols: XN Risk Phrases: 22 SECTION 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEWHarmful if swallowed. Potential Health EffectsThe toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunitiesfor direct contact with the skin or eyes and to prevent inhalation. Compound is Non-hazardous,Non-Toxic/Non-Flammable.

SECTION 4 - FIRST AID MEASURES

Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Skin:Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.Ingestion:Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.Inhalation:Remove from exposure and move to fresh air immediately.Notes to Physician:

SECTION 5 - FIRE FIGHTING MEASURES

General Information:As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), andfull protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or

Page 412 of 485

mailto:[email protected]

http://www.clearsynth.com/details.asp?id=45022344&chemical=DABIGATRAN ETEXILATE MESYLATE










































































































































































































































































































































































combustion.Extinguishing Media:In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

SECTION 6 - ACCIDENTAL RELEASE MEASURES

General Information: Use proper personal protective equipment as indicated in Section 8.Spills/Leaks:Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitablecontainer for disposal.

SECTION 7 - HANDLING and STORAGE

Handling:Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, andclothing. Avoid ingestion and inhalation.Storage:Store in a well closed container.

SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION

Engineering Controls:Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.Personal Protective EquipmentEyes:Wear safety glasses and chemical goggles if splashing is possible.Skin:Wear appropriate protective gloves and clothing to prevent skin exposure.Clothing:Wear appropriate protective clothing to minimize contact with skin.Respirators:Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure modewith emergency escape provisions.

SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Molecular Formula:

Molecular Weight:

SECTION 10 - STABILITY AND REACTIVITY

Chemical Stability:Stable under normal temperatures and pressures.Conditions to Avoid:Incompatible materials, strong oxidants.Incompatibilities with Other Materials:Strong oxidizing agents, strong bases.Hazardous Decomposition Products:Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.Hazardous Polymerization: Has not been reported.

SECTION 11 - TOXICOLOGICAL INFORMATION

RTECS#:

Page 413 of 485



























































































































































































































































































































































































































































































































































CAS#: LD50/LC50:CAS#:Draize test, rabbit, eye: 100 mg/24H Moderate; Oral,mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat:LD50 = 980 mg/kg.Carcinogenicity:Salicylamide -Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.See actual entry in RTECS for complete information.

SECTION 12 - ECOLOGICAL INFORMATION

SECTION 13 - DISPOSAL CONSIDERATIONS

Dispose of in a manner consistent with federal, state, and local regulations.

SECTION 14 - TRANSPORT INFORMATION

IATA No information available.IMO No information available.ID/ADR No information available.

SECTION 15 - REGULATORY INFORMATION

European/International RegulationsEuropean Labeling in Accordance with EC DirectivesHazard Symbols: XNRisk Phrases:R 22 Harmful if swallowed.Safety Phrases:WGK (Water Danger/Protection)

CAS# United Kingdom Occupational Exposure Limits United Kingdom Maximum Exposure Limits Canada CAS# is listed on Canada's DSL List. CAS#is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of theinformation for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of anythird party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising,even if the company has been advised of the possibility of such damages.------------------------------------------------------------------------------------------------------------

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1.1 Product identifiers Product name : Darunavir

Product Number : SML0937 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 206361-99-1









Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.

2.2 Label elements

Not a hazardous substance or mixture.



3.1 Substances Synonyms : TMC-114

UIC-94017 [(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta

Formula : C27H37N3O7S Molecular weight : 547.66 g/mol CAS-No. : 206361-99-1

Page 415 of 485


No components need to be disclosed according to the applicable regulations.



If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration.

In case of skin contact Wash off with soap and plenty of water.


If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water.






5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides




6.1 Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapours, mist or gas. For personal protection see section 8.

6.2 Environmental precautions No special environmental precautions required.

6.3 Methods and materials for containment and cleaning up Sweep up and shovel. Keep in suitable, closed containers for disposal.



7.1 Precautions for safe handling Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.


Recommended storage temperature -20 °C

Store with desiccant.

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Storage class (TRGS 510): Non Combustible Solids





Appropriate engineering controls General industrial hygiene practice.


Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Respiratory protection is not required. Where protection from nuisance le (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure No special environmental precautions required.








No data available


No data available





No data available


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log Pow: 2.72


No data available


No data available











10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides In the event of fire: see section 5



Acute toxicity No data available[(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta

Skin corrosion/irritation No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)

Serious eye damage/eye irritation No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)

Respiratory or skin sensitisation No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)


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No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)

Carcinogenicity



No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)

Specific target organ toxicity - single exposure No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)


Aspiration hazard No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)





12.4 Mobility in soil No data available([(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- buta)







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Sigma - E4630 Page 1 of 7




1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifiers Product name : Ethambutol dihydrochloride

Product Number : E4630 Brand : Sigma CAS-No. : 1070-11-7





Telephone : +91 80-6621 9400 Fax : +91 80-6621 9450


Emergency Phone # : +91-9880711432

2. HAZARDS IDENTIFICATION


Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Reproductive toxicity (Category 1B)

Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause harm to the unborn child.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram

Signal word Danger Hazard statement(s) H360 May damage fertility or the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements

none

Restricted to professional users. According to European Directive 67/548/EEC as amended. Hazard symbol(s)

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R-phrase(s) R61 May cause harm to the unborn child. S-phrase(s) S53 Avoid exposure - obtain special instructions before use. S22 Do not breathe dust. S36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S45 In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

Restricted to professional users.


3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances Synonyms : 2,2′-(1,2-Ethanediyldiimino)bis-1-butanoldihydrochloride

Emb

Formula : C10H24N2O2 · 2HCl

Molecular Weight : 277,23 g/mol Component Concentration

[S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride

CAS-No. EC-No.

1070-11-7 213-970-7

-








4.2 Most important symptoms and effects, both acute and delayed Gastrointestinal disturbance, Dermatitis, Blurred vision


5. FIREFIGHTING MEASURES



5.2 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas


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6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.





7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.


7.3 Specific end uses no data available

8. EXPOSURE CONTROLS/PERSONAL PROTECTION






Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Immersion protection Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: > 480 min Material tested:Dermatril® (Aldrich Z677272, Size M) Splash protection Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: > 30 min

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Material tested:Dermatril® (Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.









Melting point/range: 198,5 - 202,6 °C


no data available


h) Evaporation rate no data available



no data available






no data available

p) Autoignition temperature

no data available


no data available





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10.2 Chemical stability no data available



10.5 Incompatible materials no data available

10.6 Hazardous decomposition products Other decomposition products - no data available



Acute toxicity LD50 Oral - rat - 6.800 mg/kg

LD50 Intraperitoneal - mouse - 1.000 mg/kg Remarks: Peripheral Nerve and Sensation:Local anesthetic. Behavioral:Tremor. Behavioral:Convulsions or effect on seizure threshold.

LD50 Subcutaneous - mouse - 1.800 mg/kg

Skin corrosion/irritation no data available


Respiratory or skin sensitization no data available


Genotoxicity in vivo - mouse - Oral Micronucleus test

Genotoxicity in vivo - mouse - Oral sperm

Carcinogenicity


Reproductive toxicity Presumed human reproductive toxicant




Potential health effects

Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed.

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Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation.

Signs and Symptoms of Exposure Gastrointestinal disturbance, Dermatitis, Blurred vision

Additional Information RTECS: EL3854000






12.5 Results of PBT and vPvB assessment no data available




Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.












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15.2 Chemical Safety Assessment no data available

16. OTHER INFORMATION


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Sigma - M1318 Page 1 of 7





1.1 Product identifiers Product name : Milnacipran hydrochloride

Product Number : M1318 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 101152-94-7





Telephone : +91 80-6621 9400 Fax : +91 80-6621 9450


Emergency Phone # : +91-9880711432



Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301


Classification according to EU Directives 67/548/EEC or 1999/45/EC Xn Harmful R22

For the full text of the R-phrases mentioned in this Section, see Section 16.

2.2 Label elements


Signal word Danger Hazard statement(s) H301 Toxic if swallowed. Precautionary statement(s) P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/

physician.

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Supplemental Hazard Statements

none



3.1 Substances Synonyms : Toledomin

F 2207 Midalcipran Ixel (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

Formula : C15H22N2O · HCl

Molecular Weight : 282,81 g/mol CAS-No. : 101152-94-7 Hazardous ingredients according to Regulation (EC) No 1272/2008


Milnacipran hydrochloride

CAS-No.

101152-94-7

Acute Tox. 3; H301 <= 100 %

Hazardous ingredients according to Directive 1999/45/EC


Milnacipran hydrochloride

CAS-No.

101152-94-7

Xn, R22 <= 100 %

For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16










Page 429 of 485





5.2 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas




6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.





7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2.



Store with desiccant.









Page 430 of 485


Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.










no data available


no data available


h) Evapouration rate no data available


j) Upper/lower flammability or

no data available

Page 431 of 485


explosive limits




n) Water solubility no data available


no data available


no data available


no data available











10.6 Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5



Acute toxicity LD50 Oral - rat - 213 mg/kg Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Ptosis. Behavioral:Somnolence (general depressed activity). Behavioral:Convulsions or effect on seizure threshold. Skin corrosion/irritation no data available


Respiratory or skin sensitisation no data available

Germ cell mutagenicity no data available

Page 432 of 485


Carcinogenicity



Reproductive toxicity - rat - Oral Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Newborn: Sex ratio. Effects on Newborn: Growth statistics (e.g., reduced weight gain).

Reproductive toxicity - rat - Oral Effects on Newborn: Live birth index (# fetuses per litter; measured after birth). Effects on Newborn: Viability index (e.g., # alive at day 4 per # born alive).

Developmental Toxicity - rat - Oral Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system. Effects on Newborn: Delayed effects.




Additional Information RTECS: GZ1014010 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.






12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted




Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.


Page 433 of 485




14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Milnacipran hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Milnacipran hydrochloride) IATA: Toxic solid, organic, n.o.s. (Milnacipran hydrochloride)

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packaging group ADR/RID: III IMDG: III IATA: III






15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out



Acute Tox. Acute toxicity H301 Toxic if swallowed.

Full text of R-phrases referred to under sections 2 and 3

Xn Harmful R22 Harmful if swallowed.


Page 434 of 485


Name of Product : Methenamine Hippurate

CAS Name :Glycine, N-benzoyl compound with 1,3,5,7-tetraazatricyclo[3.3.1.13,7] decane(1:1)

Chemical Name : Glycine, N-benzoyl compound with 1,3,5,7-tetraazatricyclo[3.3.1.13,7] decane(1:1)

INN/ USAN/ BAN : MethenamineHippurate

Pharmacopoeial status : USP

Pharmacopoeial Name : MethenamineHippurate

CAS Registry No. : [5714-73-8]

Structure :

Molecular Formula : C6H12N4·C9H9NO3

M.W.: 319.36 g/mol

Brand Name : Hiprex

Therapeutic Category : Antibacterial

Assignee Company : NA

NH

HOO

ON

NN

N.

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Material safety Data Sheet

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LenovoLap

Typewritten text

Annexure- 11

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LenovoLap

Typewritten text

Annexure- 12

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Page 1 of 30

1). Abacavir Sulfate: for 300 kg

Sr.No Name of Raw Material UOM MTA

1N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Kg0.300

2(1S,4R)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tartrate

Kg0.402

3 Cyclopropylamine Kg 0.195

4 Succinic acid Kg 0.135

5 Sodium carbonate Kg 0.627

6 Triethyl orthroformate Kg 2.670

7 IPA-HCl (17-18%) Kg 2.700

8 Sulfuric acid Kg 0.051

9 Isopropyl alcohol Kg 13.800

2).Acrivastine for 50 kgSr.No Name of Raw Material UOM MTA

1 2,6-dibromopyride Kg 0.216

2 4-tolunitrile Kg 0.113

3 n-butyl lithium Kg 0.554

4 Triethyl amine Kg 0.071

5 Palladium(II) acetate Kg 0.002

6 Triphenyl phosphine Kg 0.003

7 Acetonitrile Kg 0.116

8 Ethanol Kg 0.350

9 Ethyl acrylate Kg 0.061

10 Triphenyl-2-pyrrolidinoeth Kg 0.183

11 Toluene Kg 3.171

12 n-butyl lithium Kg 0.254

13 Aq HCl Kg 3.485

14 Ammonium hydroxide Kg 0.122

15 Conc.H2SO4Kg 0.199

16 Methanol Kg 1.325

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LenovoLap

Typewritten text

Annexure- 13

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3). Alcaftadine: for 50 kgSr.No Name of Raw Material UOM MTA

1.11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3] benzazepine Kg

0.070

2. Formic acid Kg0.250

3. Formaldehyde Kg0.013

4. Sodium hydroxide Kg0.030

5. Acetic acid Kg0.038

6. Potassium acetate Kg0.019

7. Manganese dioxide Kg0.014

8. DCM Lit0.500

4). Anagliptin: for 50 kgSr.No Name of Raw Material UOM MTA

1tert-butyl (2-amino-2-methylpropyl)carbamate Kg

0.050

2(2S)-1-(chloroacetyl)pyrrolidine-2-carbonitrile Kg

0.046

3 Potassium carbonate Kg 0.075

4 Sodium Iodide Kg 0.020

5 Conc. HCl Kg 0.020

62-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid Kg

0.040

7 Triethyl amine Kg 0.250

8 Carbonyldiimidazole Kg 0.047

9 Acetone Lit 0.750

10 Dioxane Lit 0.750

11 Tetrahydrofuran Lit 0.700

12 Ethyl acetate Lit 0.700

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Page 3 of 30

5). Apixaban; for 10 kgSr.No Name of Raw Material UOM MTA

13-Chloro-1-(4-nitrophenyl)-5,6-dihydro-pyridine-2(1H)-one

Kg0.010

2Ethyl chloro[(4-methoxyphenyl)hydrazono] acetate

Kg0.011

3 Triethylamine Kg 0.012

4 Toluene Kg 0.075

5 Isopropanol Kg 0.016

6 10% Pd/C (~50% wet) Kg 0.001

7 Tetrahydrofuran Kg 0.285

8 5-Bromovaleryl chloride Kg 0.009


10 Sodium metabisulfite Kg 0.000

11 Ethanol Kg 0.118

12 Potassium ethoxide Kg 0.012

13 Glacial acetic acid Kg 0.189

14 Ethyl acetate Kg 0.030

15 Ammonia gas Kg 0.008

16 Propylene glycol Kg 0.084

17 Activated carbon -

18 Hyflo -

6). Atazanvir; for 50 kgSr.No Name of Raw Material UOM MTA

1 tert-Butyl {(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl} carbamate

Kg0.038

2 tert-Butyl 2-[4-(pyridin-2-yl) benzyl]hydrazinecarboxylate

Kg0.037

3 (2S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid

Kg0.045

4 1-Hydroxybenzotriazole (HOBT) Kg 0.0385 1-(3-Dimethylaminopropyl)-3-

ethylcarbodiimide hydrochloride(EDC.HCl)

Kg

0.045

6 Diisopropylethyl amine Kg 1.0007 Sulphuric acid Kg 0.0088 Conc. Hydrochloric acid Kg 0.0359 Isopropyl alcohol Kg 0.483

10 Dichloromethane Kg 1.064

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11 Acetonitrile Kg 0.27512 n-Heptane Kg 0.28313 Ethanol Kg 0.12514 Sodium bicarbonate Kg 0.01315 Hyflo Kg 0.00516 Activated carbon Kg 0.005

7). Azilsartan Medoxmil Potasium: for 250 kgSr.No Name of Raw Material UOM MTA

1Methyl-1[2’-cyanobiphenyl-4-yl)methyl]-2-ethoxy benzimidazole -7-carboxylate

Kg0.675

24-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

Kg0.158

3 Potassium 2-ethyl hexanoate Kg 0.100

4 NH2OH.HCl Kg 0.570

5 Ethyl chloroformate Kg 0.145


7 Sodium hydroxide Kg 0.178

8 p-TsCl Kg 0.198

9 DMAP Kg 0.023

10 Na2CO3Kg 0.558

11 K2CO3Kg 0.218

12 Methyl ethyl ketone Kg 3.158

13 DMSO Kg 4.460

14 IPA Kg 5.575



8). Bepotastine Besylate: for 10 kgSr.No Name of Raw Material UOM MTA1. Tartrate intermediate Kg 0.0202. Ethyl -4- bromobutyrate Kg 0.0103. K2CO3 Kg 0.0304. MEK (l) Kg 0.3205. KI Kg 0.0016. MDC Kg 0.1507. 10 % brine solution Kg 0.0808. FUMARIC ACID Kg 0.0059. Methanol (ml) Kg 0.084

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10. Acetone Kg 0.07211. MTBE Kg 0.32012. Sodium sulphate Kg 0.40013. Ethanol Kg 0.07114. NaOH Kg 0.00415. Dichloromethane Kg 0.28016. Benzene sulfonic acid Kg 0.01017. Acetone Kg 0.22018. Charcoal Kg 0.00319. MEK Kg 0.07020. IPA Kg 0.04521. Hyflow 0.003

9). Besifloxacin HCl: for 10kgSr.No Name of Raw Material UOM MTA

1.1-cyclopropyl-6,7-difluoro-4-oxo-1,4-

dihydroquinoline-3-carboxylic acid

Kg0.015

2. (3R)-azepan-3-amine mandelate Kg 0.017

3. Acetonitrile Kg 0.182

4. Triethylamine Kg 0.011

5. Acetic acid Kg 0.133

6. Acetone Kg 0.352

7. Methanol Kg 0.225

8. Sulfuryl chloride Kg 0.010

9. Charcoal Kg 0.001

10. Hyflo Kg 0.001

10). Bilastine: for 10 kgSr.No Name of Raw Material UOM MTA

1 Bromo phenethyl alcohol Kg 0.6002 Mesyl chloride Kg 0.3753 TEA Kg 0.3324 MIBK Kg 7.1005 Aq.HCl Kg 2.5006 K2CO3 Kg 0.5647 KI Kg 0.0508 Fumaric acid Kg 0.3459 Ethanol Kg 2.740

10 2 ethoxy ethyl amine Kg 0.045

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Page 6 of 30

11 2 fluoro nitro benzene Kg 0.06212 Methyl THF Kg 0.12013 K2CO3 Kg 0.10614 DMSO Kg 0.28016 Toluene Kg 0.70017 ethanol Kg 0.30018 Pd/C(5%) Kg 0.00219 NMP Kg 0.04520 Isobutyl chloroformate Kg 0.03521 2 methyl THF Kg 0.52022 5% SODIUM BI CARBONATE Kg 0.46823 IPA Kg 0.50024 Acetic acid Kg 0.27025 Toluene Kg 6.00026 ethyl acetate Kg 2.00027 5% Aq.NaHCO3 Kg 4.00028 AMMONIUM HYDROXIDE Kg 0.20029 DMF Kg 2.72030 Tri butyl phosphine Kg 0.00131 Pddba2 Kg 0.00432 ZnF2 Kg 0.07733 TMS ENOLATE Kg 0.02534 MTBE Kg 5.86035 1N HCl Kg 1.70036 MIBK Kg 3.40037 Fumaric acid Kg 0.00738 Ethanol Kg 1.14039 Aq.KOH (5%) Kg 3.40040 Methanol Kg 3.40041 MTBE Kg 5.86042 1N HCl Kg 1.700

11). Bisegliptin: for 50 kgSr.No Name of Raw Material UOM MTA

1 4-fluoro-1-(2-hydroxyacetyl)pyrrolidine-2-carboxamide

Kg0.060

2 Benzene sulfonyl chloride Kg 0.0583 TEA Kg 0.0584 Acetonitrile Kg 1.135

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5 Trimethyl amine HCl Kg 0.0306 Diethyl ether Kg 0.5007 Acetic anhydride Kg 0.0068 Water Kg 0.5009 ethyl 4-aminobicyclo[2.2.2]octane-1-

carboxylate .HBr

Kg0.061

10 DMF Kg 0.40011 K2CO3 Kg 0.061

12). Canagliflozin: for 150 kgSr.No Name of Raw Material UOM MTA

1 5-bromomethylbenzaldehyde Kg 0.2992 2-chlorothiphene Kg 0.1823 Dichloromethane Kg 3.5004 n-butyl lithium Kg 2.0135 Ethyl acetate Kg 4.3506 Toluene Kg 3.5007 Sodium hydroxide Kg 0.2008 Triethyl silane Kg 0.5259 Boron Trifluroide etherate Kg 0.310

10 Citric acid Kg 0.05011 Potassium carbonate Kg 0.15012 2,3,4,6-tetrakis-O-trimethylsilyl-D-

glucono-1,5-lactone

Kg0.736

13 Tert butyl dimethyl silyl chloride Kg 0.09314 Triethyl amine Kg 0.12515 4-fluorophenyl boronic acid Kg 0.09516 Sodium hydroxide carbonate Kg 0.57517 1,-dioxane Kg 1.00018 N-methyl morpholine Kg 0.46619 THF Kg 2.00020 Potassium fluoride Kg 0.06821 TrIs(dibenzylideneacetone) dipalladium Kg 0.02422 Methane sulphonic acid Kg 0.49823 Methanol Kg 3.50024 Pyridine Kg 0.03525 Acetic anhydride Kg 0.342

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13). Cilnidipine;for 100 kgSr.No Name of Raw Material UOM MTA

1 (2E)-3-phenylprop-2-en-1-ol Kg 0.1102 4-methylideneoxetan-2-one Kg 0.1203 2-methoxyethyl (2E)-2-(3-

nitrobenzylidene)-3-oxobutanoate Kg0.095

4 Sodium methoxide Kg 0.0455 Sodium ethoxide Kg 0.0606 Ammonia Kg 0.1507 Isopropanol Li 1.0508 Methanol Lit 0.9009 Ethanol Lit 1.000

14). Cyamemazine Tartarate: for 300 kgSr.No Name of Raw Material UOM MTA

1 Cyamemazine Maleate kg 0.330

2 L(+) Tartaric acid kg 0.120

3 Sod.Bicarbonate kg 0.360

4 Sod.sulfate kg 0.180

5 Methanol kg 2.850

6 Ethyl acetate kg 2.850

15). Dabigatran Etexylate Mesylate; for 250 kgSr.No Name of Raw Material UOM MTA

1. Ethyl 3-[{[3-amino-4-(methylamino)phenyl]carbonyl}(pyridine-2-yl)amino]propanoate

kg0.288

2. [(4-Cyanophenyl)amino]acetic acid kg 0.1783. 1,1’-Carbonyldiimidazole (CDI) kg 0.1784. Ethyl acetate kg 10.0555. Acetic acid kg 0.3006. Sodium bicarbonate kg 0.0857. n-Hexylchloroformate kg 0.1238. Potassium carbonate kg 0.2309. Ethanol kg 3.740

10. Dichloromethane kg 4.75311. Dry HCl kg 1.82512. Ammonia gas kg 0.26013. Acetone kg 3.02014. Methanesulfonic acid kg 0.038

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15. Activated carbon kg 0.01516. Hyflo kg 0.250

16). Darunavir Ethanolate:for 300 kgSr.No Name of Raw Material UOM MTA

1 KSM-1(Phenylepoxycarbamate) Kg 0.2792 KSM-2 (Isobutyl amine) Kg 1.0083 KSM-3 (4-nitrobenzenesulphonyl

chloride) Kg0.234

4 KSM-4 (Bifuranyl succinimidylcarbonate) Kg

0.180

5 Ethanol Lit 2.8716 DCM Lit 2.7907 Methanol Lit 9.9608 EtOAc Lit 4.2699 DMSO Lit 0.783

10 IPA Lit 2.70011 TEA Kg 0.27012 Raney Nickel Kg 0.09613 NaOH Kg 0.09014 Conc.HCl Kg 0.132

17). Dolutegravir Sodium;for 15 kgSr.No Name of Raw Material UOM MTA

1 Dimethyl-3-(benzyloxy)-4-oxo-4H-pyran-4,5-dicarboxylate

Kg0.024

2 Aminoactaldehyde dimethyl acetal Kg 0.0093 Methanol Kg 0.2174 Ethyl acetate Kg 0.9285 Formic acid Kg 0.2346 Sulphuric acid (62%) Kg 0.0167 Sodium bicarbonate Kg 1.2688 Methylene dichloride Kg 1.4989 (R)-3-Amino-butan-1-ol Kg 0.007

10 Acetic acid Kg 0.00811 Toluene Kg 0.60612 Sodium Chloride Kg 0.00113 2,4-Diflurobenzyl amine Kg 0.00914 10% Pd/C (~50% wet) Kg 0.00815 Tetrahydrofuran Kg 0.179

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16 Ethanol Kg 0.73817 Sodium hydroxide Kg18 Hyflo -

18). Empagliflozin ; for 50 kgSr.No Name of Raw Material UOM MTA

1 5-bromo-2-chlorobenzole acid kg 0.3792 Oxalyl chloride kg 0.1473 Dimethyl formamide kg 0.0004 Dichloromethane kg 7.0255 Anisole kg 0.1766 Aluminum trichloride kg 0.1967 Hydrochloric acid kg 0.5008 Sodium hydroxide kg 0.2509 Triethyl silane kg 0.643

10 Acetonitrile kg 1.55011 Boron trifluroide etherate kg 0.34212 Potassium hydroxide kg 0.25013 Diisopropyl ether kg 0.50014 Borane tribromide kg 0.64515 Potassium carbonate kg 0.15016 Ethyl acetate kg 2.30017 Tert butyl dimethyl silyl chloride kg 0.09318 Triethyl amine kg 0.12519 4-DMAP kg 0.00620 Sodium hydrogen carbonate kg 0.30021 D-glucono-1,5-lactone kg 0.09522 N-methyl morpholine kg 0.46623 THF kg 0.75024 Trimethyl silyl chloride kg 0.40025 Toluene kg 1.25026 Aq-sodium dihydrogen phosphate kg 0.10027 Diethyl ether kg 2.50028 Tert butyl lithium kg 0.60029 Methane sulphonic acid kg 0.47330 Methanol kg 1.15031 Acetic ahnhydride kg 0.16632 (R0-3-94-methylphenylsulfonyloxy0-

tetrahydrofuran

kg0.079

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33 Cesium carbonate kg 0.12034 Pyridne kg 0.02535 DMF kg 1.000

19). Emtricitabine; for 50 kgSr.No Name of Raw Material UOM MTA

1(2R,5S)-5-(4-Amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]-oxathiolane-2-carboxylic acid, 2S-isopropyl-5R-methyl-1R-cycloester

kg

0.125

2 Sodium borohydride kg 0.0353 Sodium hydroxide kg 0.0134 Triethylamine kg 0.0315 Methanol kg 0.9886 Toluene kg 0.4307 IPA-HCl (17-18%) kg 0.0688 Isopropyl alcohol kg 2.3409 Dichloromethane kg 1.696

10 Conc. HCl kg 0.100

20). Ethambutol Hydrochloride; for 500 kgSr.No Name of Raw Material UOM MTA

1 1,2-Dichloroethane kg 0.2852 D-2-Amino-1-butanol kg 1.2853 Sodium hydroxide kg 0.2304 IPA-HCl kg 1.0305 Isopropyl alcohol kg 2.675

21). Flurbirofen; for 50 kgSr.No Name of Raw Material UOM MTA

1 2-Bromopropionic acid Kg 0.0712 Sodium methylate Kg 0.0253 Toluene L 1.4254 Magnesium turnings Kg 0.0105 4-Bromo-2-fluorobiphenyl Kg 0.0976 Tetrahydrofuran L 0.5807 1,2-Dibromoethane Kg 0.0008 Sulphuric acid L 0.049

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Page 12 of 30

9 Potassium carbonate Kg 0.03910 Con.Hydrochloric acid L 0.385

22). Ioperidone:for 50 kgSr.No Name of Raw Material UOM MTA

1 4-Hydroxy-3-methoxy acetophenone Kg 0.0372 6-Fluoro-3-(piperidinyl-4-yl)-1,2-

benzisoxazole hydrochloride

Kg0.044

3 1-bromo-3-chloro propane Kg 0.1384 TBAB Kg 0.0025 Methanol Kg 0.5006 Toluene Kg 0.4247 Potassium carbonate Kg 0.0858 Acetonitrile Kg 0.057

23). Isoproterenol HCl:for 5 kgSr.No Name of Raw Material UOM MTA

1 Catechol kg 0.0232 Isopropylamine kg 0.0153 Chloroacetylchloride kg 0.0244 Benzyl bromide kg 0.0435 Aluminium chloride kg 0.0556 10% Palladium on carbon(M/C 50%) kg 0.0047 Butylated hydroxyltoluene kg 0.0028 Potassium Carbonate kg 0.0309 Sodium bicarbonate kg 0.005

10 Concentrated hydrochloric acid kg 0.18511 Dichloroethane kg 0.12012 Cyclohexane kg 0.25013 Ethyylene glycol kg 0.02814 Isopropyl alcohol kg 0.17515 Ethyl acetate kg 0.17016 Acetone kg 0.13017 Ethanol kg 0.55018 Methanol kg 0.35019 Dichloromethane kg 0.17520 Diisopropyl ether kg 0.08021 Activated charcoal kg 0.00122 Hyflow kg 0.005

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24). Ivabradine hcL: for 50 kgSr.No Name of Raw Material UOM MTA

1 [N-[[(7S)-3,4-dimethyoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine]

Kg0.067

2 (3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepeine-2-one

Kg0.137

3 K2CO3 Kg 0.191

4 DMF Kg 0.7505 Ethylacetate Kg 4.7506 Ethanol Kg 4.0807 1N HCL Kg 4.7508 Pd/C Kg 0.0109 Methanolic HCl Kg 0.101


25). Lacosamide: for 50 kgSr.No Name of Raw Material UOM MTA

1 D-serine kg 0.0432 Sodium hydroxide kg 0.0693 BOC anhydride kg 0.1064 Toluene kg 0.1705 Cyclohexane kg 0.4256 DCM kg 0.6417 N-methyl morpholine kg 0.0368 Isobutyl chloro formate kg 0.0499 Benzyl amine kg 0.039

10 Dimethyl sulphate kg 0.20011 TBAB kg 0.00312 HCl sol (1N) kg 0.54613 Tea kg 0.43214 Acetyl chloride kg 0.50415 Ethyl acetate kg 0.720

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26). Lafutadine; for 50 kgSr.No Name of Raw Material UOM MTA

1 2-Bromo-4-((piperidin-1-yl)methyl)pyridine

Kg0.100

2 (Z)-4-Aminobut-2-en-1-ol Kg 0.0523 Tetrahydrofuran L 1.0004 Dichloromethane L 1.6675 60%Sodium hydride Kg 0.0266 4-Nitrophenyl 2-((furan-2-

yl)methylsulfinyl)acetate

Kg0.058

7 Ethyl acetate L 0.7508 Con. Hydrochloric acid L 0.0029 Sodium hydroxide Kg 0.003

10 Ethanol L 1.600

27). Levomilnacipran HCl: for 100 kgSr.No Name of Raw Material UOM MTA

1

(1S,5R)-1-Phenyl-3-oxabicyclo [3.1.0]hexan-2-one Kg

0.090

2 Aluminum chloride (Anhydrous) Kg 0.108

3 Diethylamine Kg 0.098

4 1,3-Dibromo-5,5-dimethyl hydantoin Kg 0.148

5 Sodium azide Kg 0.068

6 Triphenylphosphine Kg 0.420

7 Sodium bicarbonate Kg 0.027

8 Sodium chloride Kg 0.018


10 Toluene Kg 2.000


12 N, N-Dimethylformamide Kg 1.200



15 Isopropyl alcohol hydrochloride (21.8 %) Kg 0.072

16 Conc.Hydrochloric acid Kg 0.250

17 Charcoal Kg 0.008

18 Micron filter paper (0.5m) - 0.200

19 Hyflo - 0.020

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28). Lurasidone HCl: for 100 kgSr.No Name of Raw Material UOM MTA

1 Cyclohexane dihydroxyl (KSM-1) Kg 0.050

2 Mesyl Chloride Kg 0.090

3 DCM Kg 1.500

4 Piperazine thioazo (KSM-2) Kg 0.100

5 Na2CO3 Kg 0.070

6 Bicylcosuccinimide (KSM-3) Kg 0.060

7 K2CO3 Kg 0.040


9 IPA Kg 1.000

10 IPA.HCl Kg 0.020

29). Meptazinol HCl: for 50 kgSr.No Name of Raw Material UOM MTA

1 2-(m-methoxyphenyl)buytronitrile kg 0.093

2 Ethyl 4-iodobutyrate kg 0.122

3 Sodium kg 0.011

4 Ammonia kg 0.482

5 THF kg 1.135

6 Toluene kg 0.556

7 Raney Nickel kg 0.026

8 Cyclohexane kg 1.297

9 Ethyl acetate kg 1.297

10 Lithium aluminium hydride kg 0.026

11 MDC kg 0.843

12 Hydrobromic acid (50%) kg 0.070

13 Isopropyl alcohol kg 1.175

14 Pd/C kg 0.006

15 formaldehyde kg 0.052

16 Methanol kg 0.560

17 IPA-HCl kg 0.084

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30). Milnacipran HCl: for 300 kgSr.No Name of Raw Material UOM MTA

1(1S*,5R*) -1- Phenyl-3-oxabicyclo(3,1,0)hexane -2-one Kg

0.257

2 Aluminum chloride Kg 0.257

3 Diethylamine Kg 0.281

4 Thionyl chloride Kg 0.206

5 Sodium azide Kg 0.095

6 Triphenylphospine Kg 0.399

7 Sodium bicarbonate Kg 0.077

8 Sodium chloride Kg 0.103


10 Toluene Kg 3.300


12 DMF Kg 1.050



15 IPA-HCl (18.5 %) Kg 0.300

16 Con. HCl Kg 0.540

17 Hyflo - 0.030

18 Charcoal - 0.015

19 Micron filter paper - 0.300

31). Mirabegron: for 50 kgSr.No Name of Raw Material UOM MTA

1 (R)-(-)-Mandelic acid Kg 0.050

2 4-Nitrophenylethylamine hydrochloride Kg 0.038

31-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

Kg0.092

4 1-Hydroxybenzotriazole Kg 0.034


6 N,N-Dimethylformamide L 0.185

7 Ethyl acetate L 1.500

8 Toluene L 0.400

9 Conc. Hydrochloric acid L 0.080

10 Sodium Carbonate Kg 0.015

11 Sodium Chloride Kg 0.003

12 Tetrahydrofuran L 0.325

13 Sodium borohydride Kg 0.015

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Page 17 of 30

14 Boron trifluoride etherate Kg 0.110

15 Methanol L 0.750

16 Sodium hydroxide flakes Kg 0.050

17 10% Pd/C (~50% wet) Kg 0.002

18 Isopropyl alcohol L 0.300

192-(4-Aminothiazol-4-yl)acetic acidhydrochloride

Kg0.034

20 Methyl tert-butyl ether L 0.213

32). Moxifloxacine HCl; for 50 kgSr.No Name of Raw Material UOM MTA

1

1-cycloproyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylicacid

kg

0.050

2 (S,S)-2,8-diazabicyclo [4.3.0] nonane kg 0.015

3 Triethyl amine kg 0.025

4 methanolic HCl kg 0.075

5 Acetonitrile kg 0.250

6 Methanol kg 0.190

7 Diisopropyl ether kg 0.250

33). Moxonidine; for 50 kgSr.No Name of Raw Material UOM MTA

1

5-Amino-4,6-dichloro-2-methylpyrimidine

Kg0.081

2 1-Acetyl-2-imidazolone Kg 0.065

3 Phosphoryl chloride Kg 0.532


5 Aqueous ammonia Kg 1.912


7 Acetic acid Kg 0.119

8 Methanol Kg 0.595

9 n-Propanol Kg 0.838

10 Oxalic acid dihydrate Kg 0.040

11 Active carbon Kg 0.004

12 Hyflo Kg 0.013

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34). Nefopam; for 50 kgSr.No Name of Raw Material UOM MTA

1[2-(chloromethyl)phenyl](phenyl)methanone Kg

0.065

2 2-methyl amino ethanol Kg 0.020

3 Sodium borohydride Kg 0.005

4 p-Toluene sulfonic acid Kg 0.016

5 Sodium carbonate Kg 0.035

6 IPA.HCl Kg 0.032

7 Ethanol Lit 0.350

8 Toluene Lit 0.400

9 Isopropanol Lit 0.500

35). Nephazoline Hydrochloride: for 100 kgSr.No Name of Raw Material UOM MTA

1 1-Naphthyl acetonitrile Kg 0.100

2 Methanol Kg 1.330

3 MTBE Kg 0.350

4 Dry HCl Gas Kg 0.500

5 Ethylenediamine Kg 0.177

6 MDC Kg 0.413

7 Isopropyl Alcohol. HCL Kg 0.194

8 Hyflo Kg 0.012

36). Perampanel: for 50 kgSr.No Name of Raw Material UOM MTA

15-Bromo-3-iodo-1,2-dihydropyridin-2-one

Kg0.093

2 Phenylboronic acid Kg 0.047


4 Cu(OAc)2Kg 0.075

5 Pd (Ph3P)4Kg 0.026

6 2-(2-cyanophenyl)-1,3,2-dioxaborinate Kg 0.047

7 2-(Tributylstannyl)pyridine Kg 0.079

8 Dimethyl formamide Kg 0.472

9 Aq.Ammonia Kg 0.463

10 MDC Kg 0.556

11 EtoAc Kg 1.580

12 Xylene Kg 0.378

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37). Rasagiline Mesylate: for 10 kgSr.No Name of Raw Material UOM MTA

1 (RS) 1-Aminoindan Hydrochloride kg 0.046

2 Propargyl benzenesulfonate kg 0.053

3 L (+)- Tartaric acid kg 0.012


5 Methanol kg 0.290

6 Toluene kg 0.400

7 Sodium hydroxide kg 0.036

8 Sulfuric acid kg 0.013

9 Acetone kg 0.380

10 Methanesulfonic acid kg 0.010

38). Rasigiline Tartarate: for 10 kgSr.No Name of Raw Material UOM MTA

1 (RS) 1-Aminoindan Hydrochloride kg 0.038

2 Propargyl benzenesulfonate kg 0.044

3 L(+)-Tartaric acid kg 0.010


5 Methanol kg 0.340

6 Toluene kg 0.330

7 Sodium hydroxide kg 0.030

8 Sulfuric acid kg 0.011

39). Rilpivirine HCl: for 50 kgSr.No Name of Raw Material UOM MTA

1 2,4-Dichloropyrimidine Kg 0.0632 (E)-3-(4-amino-3,5-

dimethylphenyl)acrylonitrilehydrochloride

Kg0.070

3 Ethanol L 0.7504 Sodium bicarbonate Kg 0.1585 4-Aminobenzonitrile Kg 0.0286 Isopropyl alcohol L 0.7807 Isopropyl alcohol-HCl L 0.0658 Methanol L 3.3759 Acetone L 3.375

Page 471 of 485

Page 20 of 30

40). Rivaroxaban: for 50 kgSr.No Name of Raw Material UOM MTA

1 4-(4-aminophenyl)morpholin-3-one kg 0.1092 2-[(2S)-oxiran-2-ylmethyl]-1H-isoindole-

1,3(2H)-dionekg

0.169

3 5-chlorothiophene-2-carboxylic acid kg 0.0934 Methanol kg 3.1545 CDI kg 0.2856 THF kg 3.7067 Potassium carbonate kg 0.1228 D-MAP kg 0.0029 Methyl amine kg 0.322

10 Thionyl chloride kg 0.08011 Dichloromethane kg 0.89912 TEA kg 0.216

41). Rosuvastatin: for 20 kgSr.No Name of Raw Material UOM MTA

1 KSM-1 kg 0.0212 KSM-2 kg 0.0183 Potassium carbonate Kg 4.0004 Aq HCl Kg 6.0005 Sodium hydroxide Kg 7.6006 Calsium chloride Kg 0.1207 Tribromo phosphene kg 10.0008 Triphenyl Phosphene Kg 12.0009 Toluene Lit 0.300

10 Acetonitrile Lit 0.400

42). Sitagliptin: for 20 kgSr.No Name of Raw Material UOM MTA

1 Trifluorophenyl butanoic acid kg 0.0202 ditertbutyl carbonate kg 0.0223 t-butanol kg 0.2004 2N sodium hydroxide kg 0.060

5 Hydrochloric acid kg 0.0306 Ethylacetate kg 0.4007 pyrazine kg 0.0168 HOBT kg 0.015

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Page 21 of 30

9 EDC kg 0.02610 DCM kg 1.00011 Methanolic HCl Ltr 0.200

43). Sodium Nitroprusside: for 20 kgSr.No Name of Raw Material UOM MTA

1 KSM-1(Potassium ferrocyanide) Kg 0.1602 Nitric acid Kg 0.2003 Sodium carbonate Kg 0.180

44). Sofosbuvir: for 50 kgSr.No Name of Raw Material UOM MTA

1 KSM-1 Kg 0.0522 KSM-2 Kg 0.0433 1-Methylimadazole Kg 0.0104 THf Lit 0.5005 Ethyl actate Lit 0.7506 Benzoyl chloride Kg 0.0607 Acetic acid Kg 0.2508 Liq Ammonia Lit 0.075

45). Solifenacin: for 20 kgSr.No Name of Raw Material UOM MTA

1 1-phenyl-1,2,3,4-tertahydroisoquinoline kg 0.1042 Ethyl chloroformate kg 0.0513 triethyl amine kg 0.0554 Dichloromethane kg 0.2155 Hydrochloric acid kg 0.1006 3-quinuclidinol kg 0.1027 Ethylacetate kg 0.4008 Toluene kg 0.7509 Sodium hydride kg 0.008

10 Succinic acid kg 0.00111 Ethanol kg 0.50012 Isopropanol kg 0.10013 isopropyl ether kg 0.100

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46). Teneliglliptin HCl: for 100 kgSr.No Name of Raw Material UOM MTA

1 (2S,4R)-1-tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

kg0.150

2 Dimethylsulphate kg 0.1213 p-Nitrobenzene sulphonyl chloride kg 0.1724 3-Methyl-1-phenyl-1-H-pyrazol-5-amine kg 0.1705 2-Chloro-N-(2-chloroethyl)ethamine

hydrochloridekg

0.190

6 2-Aminoethanthiol hydrochloride kg 0.0607 Formaldehyde kg 0.0678 1-(3-Dimethylaminopropyl)-3-

ethylcarbodiimide hydrochloridekg

0.070

9 1-Hydroxybenzotriazole kg 0.01410 Triethyl amine kg 0.16511 N-Methylmorpholine kg 0.07012 Sodium Hydride kg 0.16413 Sodium Carbonate kg 0.15014 LiOH kg 0.03515 Aqueous Hydrobromic Acid (47%) kg 0.20016 Sodium Bicarbonate kg 0.10017 Potassium Carbonate kg 0.25018 Sodium chloride kg 0.30019 Acetic acid Ltr 0.15020 Acetonitrile Ltr 2.50021 Isopropyl alcohol Ltr 2.25022 Toluene Ltr 1.75023 Dichloromethane Ltr 3.25024 Acetone Ltr 2.00025 THF Ltr 0.70026 Ethyl acetate Ltr 2.50027 Cyclohexane Ltr 0.90028 Dimethylformmide Ltr 1.00029 Methanol Ltr 0.70030 Activated charcoal kg 0.015

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Page 23 of 30

47). Ticagrelor: for 20 kgSr.No Name of Raw Material UOM MTA

1 TIC-S1 kg 0.0402 TIC-S2 kg 0.022

3 TIC-S23 kg 0.0134 Sodium Nitrite kg 0.005

5 Acetic acid kg 0.0126 K2CO3 kg 0.0437 Conc. HCl ltr 0.0628 IPA ltr 0.0819 NaHCO3 kg 0.065

10 Activated carbon kg 0.00111 Ethyl acetate ltr 0.56012 Toluene ltr 0.66713 DIPEA ltr 0.00214 Cyclohexane ltr 0.194

48). Vilazidone: for 100 kgSr.No Name of Raw Material UOM MTA

1 5-Cyanoindole (VIL-S1) Kg 0.1002 4-chlorobutyryl chloride (VIL-S2) Kg 0.1003 Sodium bis (2-methoxyethoxy)

Aluminium hydrideKg

0.130

4 Tetrahydrofuran Kg 0.9005 N,N-bis(2-chloroethyl)amine (VIL-S4) Kg 0.062

6 2-Ethoxy-carbonyl-5-aminobenzofuran(VIL-S3)

Kg0.088

7 2-chloro-1-methylpyridiniummethansulfonate

Kg0.175

8 N-methylpyrrolidine Kg 5.4009 Acetonitrile Kg 1.400

49). Vildagliptin: for 100 kgSr.No Name of Raw Material UOM MTA

1 L-Prolinamide Kg 0.0862 Chloroacetyl chloride Kg 0.0983 Isopropyl acetate Kg 0.2064 DMF Kg 0.0255 Cyanuric chloride Kg 0.069

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Page 24 of 30

6 Ethyl acetate Kg 3.0177 NaHCO3 Kg 0.1508 IPA Kg 0.3439 3-Amino-1-adamantanol Kg 0.088

10 KI Kg 0.00411 K2CO3 Kg 0.20612 THF Kg 0.25713 Methyl ethyl ketone Kg 0.476

50). Anagrelide: for 50 kgSr.No Name of Raw Material UOM MTA

1 6-chloro-1,2,3,5-tetrahydroimidazo (2,1-b)quinazolin-2(3H)-one (ANA-S1)

Kg0.055

2 Chlorine (ANA-S2) Kg 0.0343 Ferric chloride Kg 0.0504 Acetonitrile Kg 0.4205 Nitromethane Kg 1.4256 Sodium bicarbonate Kg 0.2007 2-Propanol Kg 0.420

51). Dapagliflozine: for 50 kgSr.No Name of Raw Material UOM MTA

1 KSM-1 Kg 0.1352 KSM-2 Kg 0.0333 Sodium Hydride Kg 0.0254 Sodium hydroxide Kg 0.0335 Trimethyl silane Kg 0.0196 Ethyl acetate Lit 0.3007 THF Lit 0.5008 Hexane Lit 0.7509 Dimethyl formamide Lit 0.250

10 Acetonitrile Lit 1.000

52). Tenofovir Alafenamide Fumerate: for 50 kgSr.No Name of Raw Material UOM MTA

1 Adenine Kg 0.0502 Toluene Kg 0.2253 Dimethyl formamide Kg 0.2104 Sodium hydroxide Kg 0.0015 (R)-Propylene carbonate Kg 0.042

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Page 25 of 30

6 DESMP Kg 0.1257 Magnisium tert.butoxide Kg 0.0448 DMF Kg 0.0139 Acetic acid Kg 0.012

10 HBr In acetic acid Kg 0.11411 DCM Kg 0.85312 Sodium hydroxide Kg 0.03513 Cyclohexane Kg 0.35414 NMP Kg 0.17315 TEA Kg 0.03816 CMIC Kg 0.14117 TBAB Kg 0.05918 Fumaric acid Kg 0.02219 DCM Kg 0.42520 Ethyl acetate Kg 1.23821 IPA Kg 0.85822 NaCl Kg 0.675

53). Pilferidone: for 50 kgSr.No Name of Raw Material UOM MTA

1 5-Methyl-2-(1H) Pyridone kg 0.0382 Ido benzene kg 0.0843 Potassium carbonate kg 0.0504 Copper powder kg 0.0015 Toluene kg 0.2556 DIPE kg 0.184

54). Refaximine: for 50 kgSr.No Name of Raw Material UOM MTA

1 Rifamycin O kg 0.0522 Ethyl alcohol kg 0.1083 2-amino-4-methylpyridine kg 0.0224 Ascorbic acid kg 0.0015 Hydrochloric acid kg 0.014

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Page 26 of 30

55). Hexamine Hippurate: for 500 kgSr.No Name of Raw Material UOM MTA

1 Hexamine kg 0.2702 Hippuric acid kg 0.3803 Isopropyl alcohol kg 4.840

56). Tofactinib Citrate: for 15 kgSr.No Name of Raw Material UOM MTA

1 4-Chloro-7H-pyrrolo [2,3-d]pyrimidine kg 0.0182 Para toluene sulfonyl chloride kg 0.0253 (3R, 4R)-1-Benzyl-N, 4-

dimethylpiperidin-3-aminedihydrochloride

kg0.031

4 Acetone kg 0.2195 IPA kg 0.1206 Acetonitrile kg 0.2227 Potassium carbonate kg 0.0308 DCM kg 0.1959 Sodium hydroxide kg 0.187

10 Ethyl Cyanoacetate kg 0.01412 n-Butanol kg 0.14613 DBU kg 0.006

57). Dimethyl Fumarate: for 250 kgSr.No Name of Raw Material UOM MTA

1 Fumaric acid kg 0.2502 Methanol kg 2.7503 Acetyl chloride kg 0.0854 Dichloromethane kg 1.3755 Sodium bicarbonate kg 0.005

58). Cyckserine: for 50 kgSr.No Name of Raw Material UOM MTA

1 D-serine kg 0.0392 Acetyl chloride kg 0.1353 Methanol kg 0.9004 Thionyl chloride kg 0.0705 1,4-Dioxane kg 0.2506 Acetone kg 0.4008 Hydroxyamine hydrochloride kg 0.038

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9 Sodium hydroxide kg 0.08510 IPA kg 2.00011 Aqueous ammonia kg 0.20812 Acetic acid kg 0.074

59). Sacrubitil Valsartan: for 50 kgSr.No Name of Raw Material UOM MTA

1 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

kg0.035

2 Thionyl chloride kg 0.0163 Ethanol kg 0.2714 n-heptane kg 0.3545 Succinic anhydride kg 0.1606 Triethylamine kg 0.0097 Dichloromethane kg 0.0098 Sodium hydroxide kg 0.0099 Calcium chloride kg 0.077

10 Tert. Butyl methyl ether kg 0.04611 Hydrochloric acid kg 0.23612 Acetone kg 0.01113 Isopropyl acetate kg 0.23614 Valsartan kg 0.52115 Ethyl acetate kg 0.026

60). Gatifloxacin: for 50 kgSr.No Name of Raw Material UOM MTA

1 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylicacid

kg0.047

2 2-Methyl piperazine kg 0.0173 Triethylamine kg 0.0644 Dichloromethane kg 0.3115 Methanol kg 0.753

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61). Daclatasavir: for 50 kgSr.No Name of Raw Material UOM MTA

1 Biphenyldiethanone kg 0.0702 Bromine kg 0.0943 N-Boc-L-Proline kg 0.1094 DIPEA kg 0.1275 Ammonium acetate kg 0.3726 acetic acid kg 0.2387 EDC. HCl kg 0.0568 HOBt kg 0.0469 Acetonitrile kg 1.639

10 Toluene kg 1.90511 DCM kg 1.91212 Isopropyl acetate kg 1.71513 THF kg 0.69614 Aq. HCl kg 0.348

62). Dalfampyridine: for 50 kgSr.No Name of Raw Material UOM MTA

1 Isonicotinic acid kg 0.1302 Thionyl Chloride kg 0.3153 Toluene kg 0.3954 Methanol kg 0.2055 MDC kg 1.3806 Sodium carbonate kg 0.3907 Methanalic ammonia kg 1.0158 NaOCl kg 0.8009 NaOH kg 0.260

10 MEK kg 3.17511 MTBE kg 0.52013 Acetone kg 0.685

63). Brexpiprazole: for 50 kgSr.No Name of Raw Material UOM MTA

1 7-Hydroxyquinolin-2-one (KSM-1) kg 0.0302 1-bromo-4-chlorobutane (KSM-2) kg 0.0963 Potassium hydroxide kg 0.0154 Methanol kg 0.2705 1-(1-benzothiophen-4-yl)piperazine kg 0.033

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6 Dimethyl Formamide kg 0.3007 Sodium iodide kg 0.0178 Potassium carbonate kg 0.0479 Ethanol kg 0.300

64). Flupiritine Maleate: for 50 kgSr.No Name of Raw Material UOM MTA

1 2-Amino-6-chloro-3-nitropyridine kg 0.0432 4-fluorobenzyl amine kg 0.0413 Ethylchloroformate kg 0.3954 Triethylamine kg 0.0745 1,4-dioxane kg 0.9486 Raney Ni kg 0.0077 Maleic acid kg 0.0318 Methanol kg 0.6139 Ethyl acetate kg 0.711

10 Aq Ammonia kg 0.013

65). Omagrigliptin: for 50 kgSr.No Name of Raw Material UOM MTA

1 Aminoketone (OMA-S1) kg 0.0652 Dimethylformamide dimethyl acetal kg 0.1263 THF kg 0.7404 Cyclohexane kg 1.0005 Hydrazine monohydrate kg 0.0196 Toluene kg 0.5207 Heptane kg 0.7888 Dichloromethane kg 1.3629 Methanol kg 0.063

10 p-toluenesulfonic acid kg 0.00611 2-methyl THF kg 1.42512 Triethylamine kg 0.03813 Methanesulfonyl chloride kg 0.05014 Potassium tert-butoxide kg 0.00215 Benzene sulfonic acid kg 0.05916 Isopropyl acetate kg 0.60517 OMA-S2 kg 0.06018 DMA kg 1.22819 Sodium triacetoxyborohydride kg 0.050

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20 Ammonium hydroxide kg 0.20921 Sulfuric acid kg 0.166

66). Clobazam EC: for 50 kgSr.No Name of Raw Material UOM MTA

1 2,4-Dichloronitrobenzene kg 0.1612 Aniline kg 0.1183 Iron powder kg 0.1464 DCC kg 0.3655 Monoethylmalonic acid kg 0.2356 TEA kg 0.1987 NaH kg 0.0768 Dimethyl sulfate kg 0.0559 K2CO3 kg 0.110

10 Toluene kg 4.80311 n-Heptane kg 1.47712 Cyclohexane kg 1.01513 THF kg 0.65014 MeOH kg 0.586

67). Febuxostat: for 50 kgSr.No Name of Raw Material UOM MTA

1 1-Bromo-2-methylpropane kg 0.0402 Ethyl acetate kg 0.8503 IPA kg 0.5104 TFA kg 0.4255 Hexa methyl tetra amine kg 0.0776 DMF kg 0.3807 Potassium carbonate kg 0.0778 Hydroxylamine hydrochloride kg 0.0199 Formic acid kg 0.500

10 Sodium hydroxide kg 0.01511 Methanol kg 0.500

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Annexure- 14

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Annexure- 15

Green Belt drawing after proposed expansion

Existing Green belt: 1717 Sq.m (7.07%)

Green belt after proposed expansion: 1598 (6.58%)

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Annexure- 16

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