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THE MALE AND FEMALE REPRODUCTIVE SYSTEMSExercise 42 & 47
A&P 233
MALE REPRODUCTIVE SYSTEM
Produces male games (sperm cells) in the seminiferous tubules in the testes
Transports gametes to the female reproductive tract
Secretes testosterone
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SCROTUM
The testes sit in the scrotum Sac of skin and superficial fascia that hangs
outside the abdominopelvic cavity at the root of the penis
Contains paired testicles separated by a midline septum
Its external positioning keeps the testes 3C lower than core body temperature
WALL OF THE SCROTUM In the dermis, there is
a thin layer of smooth muscle known as the dartos muscle. Contractions of this muscle causes wrinkling of the skin.
The cremaster muscle is a thicker layer of skeletal muscle that lowers and raises the testes based on temperature.
INSIDE THE SCROTUM
A fibrous (tough connective tissue) capsule covers each testis called the tunica albuginea.
TESTICLE
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The tunica albuginea gives rise to septa (partitions) that divide the testis into lobules (about 250)
Each lobule contains 3 or 4 highly coiled seminiferous tubules
These converge to become rete testis which transport sperm to the epididymis
CELLS OF THE TESTIS
Interstitial cells: produce testosterone Spermatogonia: reproduce by mitosis to
produce primary spermatocytes. Sustentacular (Sertoli) cells: form blood
testis barrier (BTB), supplies nutrients to developing sperm, protect. (Also called nurse cells)
Primary spermatocytes divide by meiosis to form secondary spermatocytes which are located closer to the lumen of the tubule.
The process of sperm formation from spermatogonia to sperm cells is called spermatogenesis
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SEMINIFEROUS TUBULES
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SEMINIFEROUS TUBULES HISTOLOGY
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SPERMATOGENESIS
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SPERMIOGENESIS: SPERMATIDS TO SPERM
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SPERM Sperm have three major regions
1. Head :contains DNA and has a helmet-like acrosome containing hydrolytic enzymes that allow the sperm to penetrate and enter the egg
2. Midpiece: contains mitochondria spiraled around the tail filaments
3. Tail :a typical flagellum produced by a centriole
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EPIDIDYMIS
Epididymis: Storage and maturation area for sperm
Its head joins the efferent ductules and caps the superior aspect of the testis
The duct of the epididymis has stereocilia that: Absorb testicular fluid Pass nutrients to the sperm
Nonmotile sperm enter, pass through its tubes and become motile (propelled by peristalsis)
Upon ejaculation the epididymis contracts, expelling sperm into the ductus deferens
EPIDIDYMIS HISTOLOGY
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SPERMATIC CORD
Contains the structures running from the testicles to the pelvic cavity. Passes through the
inguinal canal Contents:
Vas Deferens Nerves Blood Vessels
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ACCESSORY GLANDS: SEMINAL VESICLES
Lie on the posterior wall of the bladder and secrete 60% of the volume of semen Seminal fluid:
Fructose and other carbohydrates: provides energy for the sperm.
As well as some protein, citrate and prostaglandins
Join the ductus deferens enlarges to form ampulla.
Each ductus deferens joins with the seminal vesicles which forms the ejaculatory ducts
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POSTERIOR BLADDER
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POSTERIOR BLADDER
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ACCESSORY GLANDS: PROSTATE GLAND
Doughnut-shaped gland that encircles part of the urethra inferior to the bladder
Plays a role in the activation of sperm Enters the prostatic urethra during
ejaculation Constitutes about 30% of semen. Prostatic secretions function to:
Buffer the vaginal and seminal acidity, raising the pH to about 7.5 and activating the sperm (pH of the vagina is about 3.5 – 4.0)
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BULBOURETHRAL GLANDS (COWPER’S GLANDS)
Pea-sized glands inferior to the prostate
Add lubricant to the seminal fluid
Seminal fluid consists of secretions from the seminal vesicles, prostate gland and bulbourethral glands.
Semen consists of seminal fluid plus the sperm cells from the testes.
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PENIS HISTOLOGY
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SPERM SUMMARY
Produced: Seminiferous tubules Stored: Epididymis Transported through epididymis by rhythmic
peristaltic contractions as they mature Epididymis Vas Deferens Ejaculatory duct
(ampulla of vas deferens fuses with duct of seminal vesicle “ejaculatory duct”) prostate prostatic urethra (then passes the bulbourethral gland) membranous urethra penile urethra
REVIEW QUESTIONS
What is the difference between mitosis and meiosis?
What are the results of meiosis?
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SPERMATOGENESIS
Spermatogenic stem cells of the seminiferous tubules give rise to sperm in a series of events Mitosis of spermatogonia, forming spermatocytes Meiosis forms spermatids from spermatocytes Spermiogenesis: spermatids form sperm
VASECTOMY
Male sterilization Cutting and tying of
the two ductus deferens.
Prevents sperm from traveling from the testes to the spermatic cords
Sperm is reabsorbed by the body
THE FEMALE REPRODUCTIVE SYSTEMExercise 47
A&P 233
FEMALE REPRODUCTION Unlike males, who
are able to produce sperm cells throughout their reproductive lives, females produce a finite number of egg cells.
During early fetal development germ cells migrate into the ovaries and differentiate into oogonia
GROSS ANATOMY The ovaries are solid,
ovoid structures, about 2 cm in length and 1 cm in width.
Like the testes, they develop from embryonic tissue along the posterior abdominal wall, near the kidneys.
Accessory organs include the uterine tubes, uterus, and vagina.
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OVARIES
Each follicle consists of an immature egg called an oocyte
Cells around the oocyte are called: Follicle cells (one cell layer thick)
Stimulated to mature by FSH from the pituitary gland Granulosa cells (when more than one layer is
present) Thecal cells: Cells in the ovarian stroma
Thecal & granulosa cells work together to produce estrogen
A protective layer of glycoprotein forms around the egg called the zona pellucida
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OVARY HISTOLOGY
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Zona pellucida
1° Oocyte(arrested in prophase I)
Granulosa cells
Thecal cells
Nucleus
Primary Follicle
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SECONDARY FOLLICLEFluid-filled antrum
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GRAAFIAN FOLLICLE
Fluid filled antrum
Granulosa cells
Oocyte 2°
Corona radiata
Stalk
Zona pellucida
OVARIAN FOLLICLES
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FOLLICLE DEVELOPMENT
1. Primordial follicle: one layer of squamous-like follicle cells surrounds the oocyte
2. Primary follicle: one or more layers of cuboidal granulosa cells enclose the oocyte
3. Secondary follicle: has a fluid-filled space between granulosa cells that coalesces to form a central antrum
4. Graafian follicle: secondary follicle at its most mature stage that bulges from the surface of the ovary
5. Corpus luteum : ruptured follicle after ovulation
CORPUS LUTEUM
After ovulation, the remains of the follicle are transformed into a structure called the corpus luteum.
If a pregnancy occurs, it produces progesterone to maintain the wall of the uterus during the early period of development.
CORPUS ALBICANS
If fertilization does not occur, the corpus luteum will begin to break down about 2 weeks after ovulation.
Degeneration occurs when fibroblasts enter the corpus luteum and a clump of scar tissue forms called the corpus albicans.
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UTERINE TUBES (FALLOPIAN TUBES)
Receive the ovulated oocyte and provide a site for fertilization
The ampulla ends in the funnel-shaped, ciliated infundibulum containing fingerlike projections called fimbriae
Expand distally around the ovary forming the ampulla
Empty into the superolateral region of the uterus via the isthmus
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UTERINE TUBES (FALLOPIAN TUBES)
Fimbriae sweep oocyte into tube, cilia & peristalsis move it along, sperm reaches oocyte in ampulla, fertilization occurs within 24 hours after ovulation & zygote reaches uterus about 7 days after ovulation
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FALLOPIAN TUBE HISTOLOGY
Cilia sweep egg/zygote toward the uterus
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UTERUS
Hollow, thick-walled organ located in the pelvis anterior to the rectum and posterosuperior to the bladder
Body: Major portion of the uterus Fundus: Rounded region superior to the
entrance of the uterine tubes Isthmus: Narrowed region between the body
and cervix
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UTERUS
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UTERINE HISTOLOGY
Endometrium Simple columnar epithelium Stroma of connective tissue and endometrial glands
Stratum functionalis: Shed during menstruation
Stratum basalis: Replaces stratum functionalis each month
Myometrium 3 layers of smooth muscle
Perimetrium Visceral peritoneum
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UTERINE HISTOLOGY
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ENDOMETRIUM
Simple columnar epithelium
Endometrial glands
ENDOMETRIUM Proliferative phase:
glands and blood vessels scattered throughout the functional zone with little or no branching.
New glands form and endometrium thickens.
Secretory phase: glands are enlarged and have branches. Preparing the endometrium for implantation
If no implantation then endometrium breaks down and menstruation begins.
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CERVIX
Narrow lower neck of the uterus which projects into the vagina inferiorly
Cervical canal – cavity of the cervix that communicates with: The vagina via the external os The uterine body via the internal os
Cervical glands secrete mucus that covers the external os and blocks sperm entry except during midcycle
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Fornix
Endocervical canal
OVARIAN AND UTERINE CYCLES
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FEMALE: LATERAL VIEW
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VAGINA
Thin-walled tube lying between the bladder and the rectum, extending from the cervix to the exterior of the body
Wall consists of three coats: fibroelastic adventitia, smooth muscle muscularis, and a stratified squamous mucosa
Mucosa near the vaginal orifice forms an incomplete partition called the hymen
Vaginal fornix: upper end of the vagina surrounding the cervix
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FEMALE EXTERNAL GENITALIA
Vulva: all external female genital structures Mons pubis: fatty pad over the pubic symphysis Labia majora & minora: folds of skin encircling
vestibule where find urethral and vaginal openings
Clitoris: small mass of erectile tissue Bulb of vestibule: masses of erectile tissue just
deep to the labia on either side of the vaginal orifice
Perineum: Area between the vagina and anus
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FEMALE EXTERNAL GENITALIA
Perineum
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BARTHOLIN’S GLANDS
(AKA: VESTIBULAR GLANDS) The Bartholin's glands are located on each side
of the vaginal opening. They secrete fluid that
helps lubricate the vagina. Sometimes the ducts of
these glands become obstructed. Fluid backs up into the gland
and causes swelling (Bartholin's cyst)
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MAMMARY GLANDS
Modified sweat glands that produce milk (lactation) Amount of adipose determines size of breast Milk-secreting glands open by lactiferous ducts at
the nipple Areola is pigmented area around nipple Suspensory ligaments suspend breast from deep
fascia of pectoral muscles (aging & Cooper’s droop) Mammary line is a thickened ridge of embryonic
tissue that extends from the axilla to the groin.
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BREAST
Prolactin from the pituitary gland stimulates the synthesis of milk
Oxytocin from the posterior pituitary gland stimulates milk ejection
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LYMPHATIC DRAINAGE
Lymph nodes draining the breast are located in the axilla.
TODAY’S LAB
ID structures on the models View slides