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Systems Science and Health at NIH and Beyond: Areas of Interest and Funding Opportunities. Systems Science Developments at the National Institutes of Health. Patricia L. Mabry, Ph.D. Office of Behavioral and Social Sciences Research (OBSSR) National Institutes of Health - PowerPoint PPT Presentation
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Patricia L. Mabry, Ph.D.
Office of Behavioral and Social Sciences Research (OBSSR)
National Institutes of Health
American Control ConferenceSt. Louis, MOJune 11, 2009
Systems Science Developments at the National Institutes of Health
Systems Science and Health at NIH and Beyond: Areas of
Interest and Funding
Opportunities
• The National Institutes of Health (NIH)
• is the the steward of medical and behavioral research for the Nation (http://www.nih.gov/)
• is an agency of the U.S. federal government within the Department of Health and Human Services.
• Annual budgets: NIH $30B; NSF $6.5B; DoD $515B
• 27 Institutes and Centers (ICs) comprise NIH - each covering a specific domain of research, which is conducted both at NIH (intramural) and at grantee universities (extramural). See a directory of the ICs at http://www.nih.gov/icd/index.html
• The Office of Behavioral and Social Sciences Research (OBSSR) stimulates behavioral and social sciences research across the ICs. (http://obssr.od.nih.gov/index.aspx)
About NIH & OBSSR
Office of the DirectorOffice of the Director
National Instituteon Alcohol Abuseand Alcoholism
National InstituteNational Instituteon Alcohol Abuseon Alcohol Abuseand Alcoholismand Alcoholism
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National CancerInstitute
National CancerInstitute
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Dental andCraniofacial
Research
National Instituteof Dental andCraniofacial
Research
National Instituteon Drug Abuse
National InstituteNational Instituteon Drug Abuseon Drug Abuse
National Instituteof Environmental Health Sciences
National Instituteof Environmental Health Sciences
National Instituteon Aging
National InstituteNational Instituteon Agingon Aging
National Instituteof Child Health
and HumanDevelopment
National Instituteof Child Health
and HumanDevelopment
National Institute onDeafness and Other
CommunicationDisorders
National Institute onDeafness and Other
CommunicationDisorders
National EyeInstitute
National EyeInstitute
National HumanGenome Research
Institute
National HumanGenome Research
Institute
National Heart,Lung, and Blood
Institute
National Heart,Lung, and Blood
Institute
National Instituteof Mental Health
National InstituteNational Instituteof Mental Healthof Mental Health
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof General
Medical Sciences
National Instituteof General
Medical Sciences
National Instituteof Nursing Research
National Instituteof Nursing Research
National Libraryof Medicine
National Libraryof Medicine
Center for InformationTechnology
Center for InformationTechnology
Center for Scientific Review
Center for Scientific Review
National Centerfor Complementary
and AlternativeMedicine
National Centerfor Complementary
and AlternativeMedicine
National Instituteof Allergy and
Infectious Diseases
National Instituteof Allergy and
Infectious Diseases
National Centerfor ResearchResources
National Centerfor ResearchResources
Clinical CenterClinical Center
National Center on Minority Health andHealth Disparities
National Center on Minority Health andHealth Disparities
National Institute of Biomedical Imagingand Bioengineering
National Institute of Biomedical Imagingand Bioengineering
FogartyInternational
Center
FogartyFogartyInternationalInternational
CenterCenter
National Institutes of Health 27 Institutes and Centers
“Systems Science” terminology at NIH
Systems Science approaches appreciate the complexity, context, dynamic nature, and emergent phenomena associated with the problem under study SS methodologies include
Computational/mathematical modeling
Agent-based modeling
Dynamic modeling
Network Analysis
Related Terms: Complexity science
Complex adaptive systems
Non-linear dynamics
Why is NIH embracing Systems Science?
• Other approaches alone have not solved intractable health problems
• Health problems are embedded in dynamically complex systems
• Need to make best use of limited resources, evaluate trade offs
• Computers have the computational power to do what humans cannot
• keep track of large numbers of variables
• including their synergistic, cumulative and compounding effects, and
• delayed effects/changes over time
• System science methodologies used successfully in other fields – tried & true
Heuristic: to better understand problems (e.g., underlying dynamics)
Hypothesis Generation: new hypotheses and/or narrow the list of existing hypotheses prior to empirical studies
Knowledge Synthesis: synthesize existing knowledge for meaningful interpretation
Expose Gaps in Knowledge about a problem
Forecasting to aid in preparing for the future
Intervention Testing in a virtual environment: saves time and money; can do things that are impossible or unethical in the real world; and exposes unintended consequences.
What are the benefits of systems science to NIH?
Interest in systems science (SS) is growing rapidly at NIH
Systems biology is further along than SS in the behavioral and social sciences.
SS is being used to study infectious disease transmission (e.g., HIV, flu, smallpox, SARS).
Less SS is being done in chronic disease/behavioral and social determinants of health – these areas are ripe for SS
Any area of health and disease is applicable for NIH funding
Current SS at NIH
• Pandemic flu
• Tobacco use/substance abuse/addiction
• Obesity
• Health disparities/inequalities
• Social determinants of health
• Chronic disease – cardiovascular, cancer, diabetes
• Health care delivery
• Stress, mental illness
• Demography and population health
Potential Areas of Modeling for NIH
• Gene x environment interaction
• Life course questions
• Intergenerational transmission
• Linking physiological processes and social environment – e.g., biology of stress, place effects on health, poverty and health
Potential Areas of Modeling for NIH
Videocast 2007 Symposia Series on Systems Science and Health
Institute for Systems Science and Health – May 2009 - annually
Recognition of need for “cross fertilization” to encourage collaboration – Society for the Study of Human Development (SSHD) Oct 18-20 Ann Arbor, MI. SPB10- D.C. Metro area
Use the conference grant mechanism (R13/U13) to establish connections across fields
Stay tuned to the BSSR Systems Science Listserv for future opportunities to connect and collaborate
Current and Future Systems Science Activities NIH & CDC
Grant Funded Systems Science and BSSR at NIH
Joshua Epstein, Director’s Pioneer Award, NIGMS, OBSSR, 2008. Project Title: Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Disease.
David Lounsbury, R03, NIDA, 2008. Project Title: Dynamics Modeling as a Tool for Disseminating the PHS Tobacco Treatment Guideline
David T. Levy, U01, NCI, 2002-2010. CISNET. Project Title: A Simulation of Tobacco Policy, Smoking and Lung Cancer.
Linda Collins & Daniel Rivera, R21, 2007-2010. NIH Roadmap. Dynamical System /Related Engineering Approach /Improving Behavioral Intervention
Daniel Rivera, K25, NIDA, OBSSR. Control Engineering Approaches to Adaptive Interventions in Drug Abuse Prevention.
Keith Warren, R21, NIDA Maintenance and correlates of cooperative behavior in therapeutic communities
Joseph Eisenberg, R01, NIAID, Environmental change and diarrheal disease
John Morgenstern, U13, NIAAA, Transdisciplinary Approaches to Mechanisms of Behavior Change in Alcohol: Facilitating Research Across Disciplines and Institutions.
Grant Funded Systems Science and BSSR at NIH
PAR-08-224 – (R21) Using Systems Science Methodologies to Protect and Improve Population Health. Awards pending.
RFA-HD-08-023 (R01), Innovative Computational and Statistical Methodologies for the Design and Analysis of Multilevel Studies on Childhood Obesity (R01). Awards pending.
CISNET - Cancer Intervention and Surveillance Modeling Network. Modeling to guide public health research and priorities. NCI. CISNET II, funded under RFA-CA-05-018, is focused on the application of already developed models to study the population impact of existing or emerging cancer control interventions. http://cisnet.cancer.gov
MIDAS – Modeling Infectious Disease Agents Study
IMAG – Interagency Modeling and Analysis Group http://www.nibib.nih.gov/Research/MultiScaleModeling/IMAG PAR-08-023 Predictive Multiscale Models of the Physiome. Open through 2010. Simulate a physiological system at more than one biological scale, including behavioral and population levels.
NIH has a variety of mechanisms to address most any stage of the scientific development cycle:
R03 – small grant, in general $100K for two years
R21 - $275K Direct cost for a two year period
R01 – up to $500K per year for up to 5 years
R13/U13 – conference grant
Training and career development awards are also encouraged
Refer to www.nih.gov for detailed funding info – I can send a resource page to you
Funding Mechanisms at NIH
Open Funding Opportunity Announcements at NIH in Systems Science
PAR-08-224 Using Systems Science Methodologies to Protect and Improve Population Health (R21).
PAR-08-212, -213, -214 Methodology and Measurement in the Behavioral and Social Sciences (R01, R21, R03).
RFA-07-079, -080 Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01, R21)
PAR-08-023 Predictive Multiscale Models of the Physiome in Health and Disease (R01).
**To stay apprised of new Funding Opportunity Announcements, join the Behavioral and Social Science-Systems Science Listserv. Send email to Patty Mabry [email protected] to join.
Other Relevant Funding Opportunity Announcements
Geographic and Contextual Influences on Energy Balance-Related Health Behaviors
R01 http://grants.nih.gov/grants/guide/pa-files/PA-08-192.html R21 http://grants.nih.gov/grants/guide/pa-files/PA-08-193.html
Mechanisms of Behavior Change Initiation (MOBCI) for Drinking Behavior Solicitation Number: NIAAA-09-07 - **expired**
**To stay apprised of new Funding Opportunity Announcements, join the Behavioral and Social Science-Systems Science Listserv. Send email to Patty Mabry [email protected] to join.
NIH Roadmap for Medical Research http://nihroadmap.nih.gov
The NIH Roadmap is a trans-NIH initiative funded through the Common Fund – ALL Institutes and Centers (ICs) participate.
Initiatives funded through the Roadmap/Common Fund fit into one or more of these major themes and address specific roadblocks or gaps to:
Foster high-risk/high-reward research
Enable the development of transformative tools and methodologies
Fill fundamental knowledge gaps
Change academic culture to foster collaboration
Director’s Pioneer Award http://nihroadmap.nih.gov/pioneer Announced Oct
New Innovator Award http://nihroadmap.nih.gov/newinnovator Announced Oct
Science of Behavior Change
Other initiatives
NIH Biomedical Information Science and Technology Initiative (BISTI).
An initiative to enhance the application of computer science to problems in biology and medicine http://www.bisti.nih.gov/bistic2.cfm
NIH Blueprint for Neuroscience Research http://www.neuroscienceblueprint.nih.gov/
Comparative Effectiveness - $400M ARRA funds. CER definition: a rigorous evaluation of the impact of different options that are available for treating a given medical condition for a particular set of patients.
Advice for Getting NIH Funding
Identify a research question or area for which your skills are needed.
Identify collaborators with the content expertise, NIH track record of success
Identify pertinent FOAs
Identify one or more IC’s who might be interested
Develop a concept paper
Talk to Program Staff (Scientific Contacts)
Prepare application well before deadline – send draft out for feedback.