SYSTEMS BIOLOGY IN DRUG DISCOVERY

SYSTEMS BIOLOGY IN DRUG DISCOVERY -

: GAUSS-BAYES 4. ( . ). . .

:. . . .

. . . . i i (microarrays) Microarray .

. Microarrays :

Microarrays .

DNA . .

YEAST 2 HYBRID (2) - , (transcription gene ) (reporter gene)

transcription gene , (binding domain) reporter gene (UAS) (activation domain) reporter gene.

reporter gene .

transcription gene Bait-Prey ( )

:AP (Affinity purification) .

TAP (Tandem affinity purification) AP .

( ) ( ) . in vitro in vivo. : TAP

. ( , , - ). . 3 = =7

(REGULATORY NETWORKS)REVEAL (REVerse Engineering Algorithm): . . REVEAL .

DBN (Dynamic Bayesian Network).

(hidden factors) GAUSS-BAYES

BAYES BAYES (SBN) BAYES (DBN). 1,2 . G ( i) . . BAYES DAG (directed acyclic graph) .

Bayes (-) q. .. :

DAG . DAG DAG. CPDAG (completed partially directed acyclic graphs). ( ) ( ) DAG . DAG v . .BAYES GAUSSIAN ANALYSIS , (). O AUC .

(TP/FP=5) RAF (RAF signaling pathway)

RAF . 11 1200 (cytometry).

11 6 .

( ) ( ). AUC TF/FP . . .