6
Contact Us! For more information on the articles in this newsletter or to suggest future articles, please contact us at: [email protected] ©2009 Sysmex America, Inc. All rights reserved. Published by: Sysmex America, Inc. One Nelson C. White Parkway Mundelein, IL 60060 President’s Message In my previous President’s message, you will recall our focus on operational efficiency as a means by which laboratorians can contribute to the reshaping of healthcare at a clinical laboratory level. This, in turn, contributes to the efficiency and productivity of the hospital overall. A critical component of laboratory efficiency is clinical excellence. The spectrum of clinical excellence begins with the core technology and clinical utility of a laboratory’s instrumentation and ends with diagnosis, treatment and improved quality of life for the patient. This is the focus of my message. “Reshaping health care system forces lobbyists into unlikely alliances” was the headline of a May 19, 2009 article by The Associated Press highlighting the extraordinary lobbying efforts of healthcare stakeholders. AARP, who represents 40 million older members, is noted as having drawn 50,000 callers to a “town hall” telephone conference call on healthcare. The American Medical Association is credited for orchestrating contact between law makers and 400,000 patients. Millions of advertising dollars are being spent to “sell” conflicting views on healthcare reform. While these types of remarkable activities are expected when there is so much at stake, we as clinical laboratory professionals are charged with the task of clinical excellence when patient quality of life is at stake. It is my philosophy – and one that I share with our employees – that we are not just selling an analyzer, a software solution or a laboratory test. We are helping medical technologists provide accurate patient results – results for patients who could very well be the spouse, mother, father, child or sibling of one of our own. As clinical laboratory professionals, we cannot guarantee healthcare outcomes on a national stage. However, we can be assured of our contributions to reshaping healthcare from a clinical perspective. Clinical excellence begins with a substantial commitment to research excellence. For forty years, Sysmex has focused on the development of both our core expertise and new diagnostic technologies – resulting in a “best in class” hematology offering. Sysmex instruments consistently earn the industry’s highest rankings (IMV Service Trak™ and MD Buyline) for reliability and performance – key influencers in a clinical laboratory’s hematology analyzer purchasing decision. Sysmex consistently expands the clinical utility of its instruments. In fact, Sysmex has more advanced analytical parameters with proven utilities on one analyzer than any other manufacturer. Our automated, RET-He (Reticulocyte Hemoglobin Equivalent) parameter provides the physician the ability for early recognition of functional iron deficiency in end stage renal disease (ESRD) patients. Our 7-part differential (traditional 5-part differential plus NRBCs and immature granulocytes), offers the only automated parameters that assist physicians with the medical management of diseases such as anemias, leukemias, platelet anomalies, infections and bone marrow transplants. More clinical laboratories are realizing the value of providing these automated, advanced parameters to physicians as they assess instrument capability relative to their effect on service lines, care pathways, medical errors and patient flow. At Sysmex, we understand the importance of our core technologies and the need to expand the clinical utility of our products. We understand the clinical laboratories’ needs to produce reliable, clinically-relevant results in spite of economic and staffing concerns. We understand your hospitals’ needs to accurately diagnose and code patients upon admission to ensure appropriate reimbursement funding. We understand the need for continued research excellence that ultimately contributes to the industry’s shift from the use of traditional diagnostics to the use of additional, personalized disease diagnostics and treatment. That’s why we invested $90 million dollars in a recently-completed technical park that will drive our research and development efforts with highly regarded institutions throughout the world. We are a company that cares. Recently, The New York Times printed an ad from the Center for Companies That Care announcing their selection of companies for the Center’s 2009 Companies That Care Honor Roll. Sysmex America, Inc. was among this list of distinguished employers. The selection criteria for this award and The New York Times ad can be found on page 4 of this newsletter. While this award heralds Sysmex America’s corporate commitment to its employees and to society, it also sets forth the backdrop from which our employees work to provide clinical excellence for “one of their own.” We are proud to have reached these high standards. Above all, we are a company that cares about better diagnostics, better treatment and better outcomes. John Kershaw President Sysmex America, Inc. Summer 2009 Sysmex Remote Monitoring: Paving the Way for e-Tools Sysmex America, Inc. (SAI) has developed a suite of capabilities, called ‘ e-Tools’ to provide a range of support for customers’ instruments and operational efficiency. Utilizing the speed and connectivity of today’s Internet, Sysmex supports customers in their efforts to assure the quality of their clinical laboratory results and to optimize instrument performance. InsightIQAP e-Verify calibration verification Remote system monitoring Cycle-based maintenance Many of Sysmex America’s customers are already benefiting from e-Tools’ innovative services, such as 24 x 7 IQAP reports on demand, or cycle-based maintenance. The full suite of Sysmex’s e-Tools includes InsightIQAP, e-Verify calibration verification, cycle- based maintenance and remote system monitoring. All of these e-Tools are accessed using Sysmex’s SNCS TM (Sysmex Network Communications Systems) connectivity. e- Tools help laboratories to: – Ensure system quality and confidence in results – Automate system management – Reduce downtime – Reduce non-testing, task time and costs – Readily document processes to meet regulatory needs While continuous real-time capture and analysis of instrument performance data enables a proactive response to potential instrument problems, other electronic tools within the Sysmex suite of e-Tools contribute to the generation of accurate patient results that aid in patient assessment and treatment. An expanded explanation of these e-Tools follows. Continued on page 2 We are not just selling an analyzer, a software solution or a laboratory test. We understand your hospitals’ needs to accurately diagnose and code patients upon admission...

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Contact Us!For more information on the articles in this newsletter or to suggest future articles, please contact us at: [email protected]

©2009 Sysmex America, Inc.

All rights reserved.

Published by:Sysmex America, Inc.

One Nelson C. White ParkwayMundelein, IL 60060

President’s MessageIn my previous President’s message, you will recall our focus on operational efficiency as a means by which laboratorians can contribute to the reshaping of healthcare at a clinical laboratory level. This, in turn, contributes to the efficiency and productivity of the hospital overall. A critical component of laboratory efficiency is clinical excellence. The spectrum of clinical excellence begins with the core technology and clinical utility of a laboratory’s instrumentation and ends with diagnosis, treatment and improved quality of life for the

patient. This is the focus of my message.

“Reshaping health care system forces lobbyists into unlikely alliances” was the headline of a May 19, 2009 article by The Associated Press highlighting the extraordinary lobbying efforts of healthcare stakeholders. AARP, who represents 40 million older members, is noted as having drawn 50,000 callers to a “town hall” telephone conference call on healthcare. The American Medical Association is credited for orchestrating contact between law makers and 400,000 patients. Millions of advertising dollars are being spent to “sell” conflicting views on healthcare reform. While these types of remarkable activities are expected when there is so much at stake, we as clinical laboratory professionals are charged with the task of clinical

excellence when patient quality of life is at stake.

It is my philosophy – and one that I share with our employees – that we are not just selling an analyzer, a software solution or a laboratory test. We are helping medical technologists provide accurate patient results – results for patients who could very well be the spouse, mother, father, child or sibling of one of our own. As clinical laboratory professionals, we cannot guarantee healthcare outcomes on a national stage. However, we can be assured of our contributions to reshaping

healthcare from a clinical perspective.

Clinical excellence begins with a substantial commitment to research excellence. For forty years, Sysmex has focused on the development of both our core expertise and new diagnostic technologies – resulting in a “best in class” hematology offering. Sysmex instruments consistently earn the industry’s highest rankings (IMV Service Trak™ and MD Buyline) for reliability and performance – key influencers in a clinical laboratory’s hematology analyzer

purchasing decision.

Sysmex consistently expands the clinical utility of its instruments. In fact, Sysmex has more advanced analytical parameters with proven utilities on one analyzer than any other manufacturer. Our automated, RET-He (Reticulocyte Hemoglobin Equivalent) parameter provides the physician the ability for early recognition of functional iron deficiency in end stage renal disease (ESRD) patients. Our 7-part differential (traditional 5-part differential plus NRBCs and immature granulocytes), offers the only automated parameters that assist physicians with the medical management of diseases such as anemias, leukemias, platelet anomalies, infections and bone marrow transplants. More clinical laboratories are realizing the value of providing these automated, advanced parameters to physicians as they assess instrument capability relative to their effect on service lines, care

pathways, medical errors and patient flow.

At Sysmex, we understand the importance of our core technologies and the need to

expand the clinical utility of our products. We understand the clinical laboratories’ needs to produce reliable, clinically-relevant results in spite of economic and staffing

concerns. We understand your hospitals’ needs to accurately diagnose

and code patients upon admission to ensure appropriate reimbursement funding. We understand the need for continued research excellence that ultimately contributes to the industry’s shift from the use of traditional diagnostics to the use of additional, personalized disease diagnostics and treatment. That’s why we invested $90 million dollars in a recently-completed technical park that will drive our research and development efforts with highly regarded institutions throughout the world. We are a

company that cares.

Recently, The New York Times printed an ad from the Center for Companies That Care announcing their selection of companies for the Center’s 2009 Companies That Care Honor Roll. Sysmex America, Inc. was among this list of distinguished employers. The selection criteria for this award and The New York Times ad can be found on page 4 of this newsletter. While this award heralds Sysmex America’s corporate commitment to its employees and to society, it also sets forth the backdrop from which our employees work to provide clinical excellence for “one of their own.” We are proud to have reached these high standards. Above all, we are a company that cares about better diagnostics, better treatment and better outcomes.

John Kershaw President Sysmex America, Inc.

Summer 2009

Sysmex Remote Monitoring: Paving the Way for e-Tools Sysmex America, Inc. (SAI) has developed a suite of capabilities, called ‘e-Tools’ to provide a range of support for customers’ instruments and operational efficiency. Utilizing the speed and connectivity of today’s Internet, Sysmex supports customers in their efforts to assure the quality of their clinical laboratory results and to optimize instrument performance.

• Insight™ IQAP• e-Verify calibration verification• Remote system monitoring• Cycle-based maintenance

Many of Sysmex America’s customers are already benefiting from e-Tools’ innovative services, such as 24 x 7 IQAP reports on demand, or cycle-based maintenance. The full suite of Sysmex’s e-Tools includes Insight™ IQAP, e-Verify calibration verification, cycle-based maintenance and remote system monitoring. All of these e-Tools are accessed using Sysmex’s SNCSTM (Sysmex Network Communications Systems) connectivity.

e- Tools help laboratories to:– Ensure system quality and confidence in results– Automate system management– Reduce downtime– Reduce non-testing, task time and costs– Readily document processes to meet regulatory needs

While continuous real-time capture and analysis of instrument performance data enables a proactive response to potential instrument problems, other electronic tools within the Sysmex suite of e-Tools contribute to the generation of accurate patient results that aid in patient assessment and treatment. An expanded explanation of these e-Tools follows.

Continued on page 2

❝We are not just sellingan analyzer, a software

solution or a laboratory test.

❝We understand your hospitals’

needs to accurately diagnose and code patients upon admission...

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Insight™ IQAPInsight IQAP is Sysmex’s web-based, inter-laboratory quality assessment program for X-Series hematology analyzers. It allows customers to meet their regulatory requirements by documenting peer comparison analyzer data, while eliminating manual steps. Insight eliminates the tedious, time consuming process of manually copying data by utilizing an easy, electronic upload process as needed, at the laboratories’ convenience. The system’s concise, easy-to-read reports can be generated on demand (24 x 7). Lot-to-date, end-of-lot, or month-to-date reports can be quickly generated based on the laboratories’ choice.

e-Verify Calibration Verification

e-Verify enables Sysmex instrument operators the convenience of managing and scheduling semi-annual calibration verification to fit laboratory staffing and workflow constraints. Sysmex notifies the laboratory well in advance of this event, schedules a convenient appointment and sends along the materials and reminders for the event(s). When verifying calibration, the analyzer is in use for approximately 20 minutes, thus minimizing downtime and maximizing labor utilization. e-Verify also assures compliance with laboratory accrediting agencies, providing full documentation of the process for laboratory records and inspections, while providing the laboratory with peace-of-mind.

Cycle-based Maintenance

Cycle-based instrument maintenance is triggered automatically, based on cycle count rather than on static time intervals.

Preventive maintenance, when linked to system use and test volume, is performed when needed.

Remote Monitoring - SNCS™SNCS uses secure connectivity and internet speed to capture and analyze Sysmex instrument performance data that links to the Sysmex tracking and dispatch system in Mundelein, Illinois. SNCS provides quick, proactive response to potential problems, reducing the number of unscheduled service calls. An alert signals SAI’s Technical Assistance Center for process review and handling of the condition. This may result in a variety of responses from the Sysmex service, field engineering, and applications specialist teams.

SNCS enables SAI to proactively and rapidly provide problem resolution for Sysmex instruments – often even before the customer is aware of a technical condition.

SNCS is the software system that continuously monitors Sysmex instruments to securely capture and analyze “real-time” instrument performance data. By remotely monitoring Sysmex instruments on-line and in real-time, Sysmex can automatically and proactively connect customers to the Sysmex service tracking and dispatch system for rapid problem resolution. SNCS and the entire Sysmex suite of e-Tools was designed to withstand the rigorous evaluation from the most demanding customer IT and security teams who are responsible for ensuring their institutions’ Health Insurance Portability and Accountability Act (HIPAA) compliance. In fact, e-Tools’ security has even passed the scrutiny of government-based healthcare accounts.

To find out how you can keep your clinical laboratory operating at peak efficiency with the use of the Sysmex suite of e-Tools, contact your Sysmex Account Manager.

Sysmex Network Communications System Remote MonitoringToday almost 50% of Sysmex instruments across the U.S. and Canada are already enjoying the benefits of Sysmex’s highly successful remote instrument monitoring program, Sysmex Network Communications System - SNCS™.

What is SNCS? SNCS is a software system that provides continuous monitoring of your Sysmex instruments to capture and analyze “real-time” performance data. By remotely monitoring your instruments on-line and in real-time, Sysmex can automatically and proactively connect to our Sysmex service tracking and dispatch system even before you know there is a problem to report.

“During implementation, the IPU on our XT-2000i appeared to be non-functional. It turns out that installation of our network anti-virus software had compromised some required files. With SNCS, Sysmex was able to re-establish the files immediately without us having to wait for a field service representative to get here,” said Jamie Williams, Laboratory Manager, Sutter Coast Hospital, Crescent City, California.

Proactive Service. By connecting your instruments to your network and providing Sysmex remote access to them, SNCS continuously monitors the instrument’s performance and transmits performance alerts based on instrument conditions. Your instrument is monitored with no impact on instrument performance, and no user intervention is required. If SNCS identifies an issue, it automatically sends an alert signal to Sysmex’s Technical Assistance Center (TAC) for a proactive service review and handling. SNCS alerts help Sysmex match the right level of expertise at the right time, whether it’s an onsite field engineer, application specialist or remote phone support specialist.

Faster Turnaround Time in the laboratory depends on instrument reliability and uptime. With SNCS, Sysmex is able to provide 24-hour real-time capture and analysis of instrument performance data which enables a proactive response to potential instrument problems. Since implementing SNCS connectivity our customers have reported a reduction in instrument downtime and a reduction in unscheduled service calls.

“We are seeing the momentum build as more and more laboratories are connecting every day to SNCS,” explains Steve Postma, Technical Services Assistant Director at Sysmex. “This year we expect to see 50% more new instruments being monitored than we did last year. With more customers enabling SNCS connections, we are also looking for more ways that SNCS can be used to support the lab’s service delivery.”

SNCS Helps Manage QC Data. Another way SNCS can help is by enabling instrument operators to directly upload instrument QC data for Insight analysis and print reports directly on the instrument’s printer. This saves time by eliminating the manual steps of saving data to a flash drive or floppy drive and transferring it to another computer for review. This feature is used daily by many Sysmex customers.

Continued from front page

Continued on next page

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Security. SNCS-enabled instruments require only outbound communication permission via port 443. SNCS complies with relevant firewall requirements, without the need for modification, by initiating all communications from behind the firewall. Communications are secured by using encryption, SSL authentication and multi-level access privileges. The SNCS connection is valid only to the Sysmex applications remote server.

Learn More About SNCS. For additional information about SNCS, Sysmex customers may want to visit Sysmex America’s online Customer Resource Center (CRC). The CRC offers a wealth of support tools designed to educate and empower clinical laboratorians about SNCS and other Sysmex products and services.

Getting Connected to SNCS. Set up is easy and quick. “SNCS was very simple to set up. Our IT department supported us and our Sysmex Field Service

Representative had it up and going within a day,” said Megan LaPlant, Hematologist, Calais Hospital, Calais, Maine.

SNCS Qualified Instruments & Systems • XE-Series hematology analyzers

• XT-Series hematology analyzers

• XS-Series hematology analyzers

• HST-N - Series Hematology Automation System

• SP-Series slidemaker/stainer

• CellaVisionTM digital morphology system

• Sysmex WAM (for remote support access)

Getting Instruments Connected to SNCS. Connecting to SNCS is straightforward and can be accomplished immediately once the lab’s IT team has completed the following requirements:

Instruments Require WhoNetwork IP address assigned (one per instrument)

Customer’s IT Department

Connection to the network (active RJ45 jack)

Customer’s IT Department

Outbound access to Sysmex via your network port 443

Customer’s IT Department

Anti-virus software installed on each instrument’s PC

Customer’s IT Department

Getting Started.

To get started, call the Sysmex Technical Assistance Center (TAC) at 1-888-8-SYSMEX.

IT Department Questions and Sysmex Support.

For any IT-related questions, call the Sysmex Technical Assistance Center (TAC) at 1-888-8-SYSMEX.

Sysmex Network Communications System Remote Monitoring Continued

Building SNCS for Tomorrow. The success of SNCS technology has led Sysmex to develop service-related enhancements as well as new features that help support the laboratory’s clinical and operational objectives by enhancing your Sysmex equipment and reducing service interventions. Recently introduced, e-Verify is a remote calibration verification program designed to help laboratories meet CLIA, CAP and state requirements for calibration verification. Sysmex also now offers cycle-based instrument maintenance, which aligns preventive maintenance activity based on instrument cycle monitoring through SNCS, rather than preventive maintenance based on static time intervals.

Sysmex America, Inc. Awarded Highest Vendor Designation by MedAssets Supply Chain Systems Customer Savings and Satisfaction Key FactorsSysmex America has once again earned MedAssets Supply Chain Systems Platinum Vendor award. Award criteria is based on improving customer savings and customer satisfaction, timely processing of reports’ filing and fee schedules’ submissions, continuous purchase volume growth and MedAssets’ philanthropic support.

“As evidenced by Sysmex America’s sales growth, it is clear that our customers have embraced the reliability and performance of Sysmex products, enabling them in turn to provide the highest quality of care in their communities. Sysmex also has proven to be a responsible clinical laboratory partner in meeting the operational and financial needs of our customers,” said Mary Ellen Kimmeth, MedAssets Supply Chain Systems Vice President, Laboratory Division & Outreach Services.

“Sysmex America is honored to be recognized among some of the nation’s best healthcare vendors as a MedAssets Supply Chain Systems Platinum Vendor designation recipient. We also have found MedAssets to be a committed partner and trust that our continued working relationship will be beneficial to the mutual

customers we serve,” said Tom Tojo, National Account Manager, Sysmex America. Previously, SAI has won Bronze, Silver, Gold and Platinum Vendor designations from MedAssets Supply Chain Systems. Sysmex America and other MedAssets Supply Chain Systems award recipients were honored during the GPO’s annual Healthcare Business Summit in the spring.

MedAssets partners with healthcare providers to improve their financial strength by implementing spend management and revenue cycle solutions that help control cost, improve margins and cash flow, increase regulatory compliance, and optimize operational efficiency. MedAssets serves more than 125 health systems, 3,300 hospitals and 30,000 non-acute care healthcare providers. For more information, go to www.medassets.com.

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Center for Companies That Care is an independent, not-for-profit organization dedicated to enhancing the well-being of employees, families and communities by engaging employers in cultivating supportive working conditions and strengthening local communities. Recently, the Center announced Sysmex America’s selection to its 2009 Companies That Care Honor Roll – an announcement that was heralded in a New York Times May advertisement.

“As an organization, we are keenly aware of our employees’ contributions to our business success and of our society’s need for corporate citizenship,” said Karen Stoneman, Vice President of Human Resources, Sysmex America, Inc. Sysmex America’s 400 employees are among the nearly 4,000 employees worldwide that make up the Sysmex team of professionals.

Sysmex America’s Commitment to Employees and Society RecognizedNew York Times Ad Sets Forth Company Attributes

10 Characteristics of a Company That CaresCompanies That Care prize employees and are committed to community service. To sustain these values, Companies That Care consistently demonstrate the following 10 Characteristics in their work environment. These 10 Characteristics define the standard for all organizations desiring to be recognized as caring, responsible organizations.

Sysmex America’s selection was based on the company’s consistent practice of the “10 Characteristics of a Company That Cares”. Also considered in the selection process were Sysmex America’s employee survey data and an overall review of company practices by the Honor Roll Independent Review Panel consisting of human resources, community relations, academia and organizational development professionals.

“The Sysmex Way, our company philosophy, succinctly defines our core behaviors toward our employees and society, among which support the mission, value and mind of Sysmex Corporation. We are honored that our philosophy and the Center’s ‘10 Characteristics of a Company That Cares’ are in alignment,” said John Kershaw, President and CEO, Sysmex America, Inc.

When Sysmex America employees from the Information Systems, Customer

Service and Operations departments assembled their collective “design” talents,

a new shipping form for Sysmex America’s customers was created that

benefits customers and SAI’s shipping partners. Customers receive the

SAP-generated form in an email with their order that provides a direct

hyperlink to the appropriate web site for shipment tracking.

“Currently our customer service representatives’ field

about 2,500 calls a month with more than

1,000 of those calls attributed to shipment

tracking requests. This form now frees our

SAI Employee Initiative + Shipping Partner Feedback

= Automatic Tracking

customer service representatives to perform additional value-added services such

as shipping or volume consultation to reduce customers’ costs associated with

inventory and shipping charges,” said Judy Bosko, Sysmex America’s Vice President

of Operations.

Developed as a result of feedback obtained from SAI’s customer service team

and its shipping partners, SAI customers now have all of the information they

need to efficiently track their orders in one easy-to-use document. The

form includes need-to-know information such as PO numbers,

items and quantities ordered, shipping company, and

tracking numbers. “Customer response has been

overwhelmingly positive with requests to expand

the form design to include additional

features such as multiple email addresses,”

said Bosko.

1. Sustain a work environment founded on dignity and respect for all employees

2. Make employees feel their jobs are important

3. Cultivate the full potential of all employees

4. Encourage individual pursuit of work/life balance

5. Enable the well-being of individuals and their families through compensation, benefits, policies and practices

6. Develop great leaders, at all levels, who excel at managing people as well as results

7. Appreciate and recognize the contributions of people who work there

8. Establish and communicate standards for ethical behavior and integrity

9. Get involved in community endeavors and/or public policy

10. Consider the human toll when making business decisions

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A study titled “Day-to-Day, Week-to-Week, and Day-of-the-Week Variations in Tests of Anemia and Iron Status in Hemodialysis Patients” has identified Sysmex’s Reticulocyte Hemoglobin Equivalent (RET-He) parameter result as key input used by physicians to assist in Anemia treatment decisions in ESRD patients on hemodialysis. David Van Wyck, M.D., Vice President of Clinical Affairs at DaVita Inc., and Emeritus Professor of Medicine and Surgery at the University of Arizona College of Medicine, in Tucson et al. followed five hematologic parameters in 30 patients undergoing hemodialysis three times a week. The patients were followed for 12 consecutive treatment days. The parameters studied were Hb, Hct, reticulocyte Hb (RET-He or CHr), TSAT and ferritin levels.

The purpose of the DaVita®1 study was to evaluate the clinical value of these five parameters for supporting the physician’s ability to make informed dosing decisions for ESA and IV iron therapy.

According to Dr. Van Wyck, “It has been difficult to know if the observed variability is within the ‘expected ranges’ for these patients or if changes in these markers signify a trend. Prior to this study, little information was available on expected day-to-day, within-patient variability among patients undergoing dialysis.”

Over the course of the study, ESA doses were held constant and IV iron therapy was withheld. Same-sample analytic variability was measured, as was within-patient “biologic” variability. The number of sampling days needed to determine the true average value for each analyte was calculated with a 5% significance level

and an 80% level of accuracy.

For all five parameters, “biologic” variation exceeded analytic variation, particularly for TSAT and ferritin. Hb and Hct were affected by the day of the week blood was drawn, with Hb levels averaging 0.06g/dL higher midweek versus those obtained the first dialysis day of the week. Hb, Hct and RET-He/CHr values were measured

using a Sysmex XE-2100 instrument.

The authors concluded that because of the high “biologic” variation observed, multiple test days are needed to achieve clinically meaningful accuracy and that Hb, Hct and reticulocyte Hb (RET-He or CHr) were useful analytes to guide ESA and IV iron therapy, whereas ferritin and TSAT were not reliable guides for month to month dose adjustments for ESA or IV iron. They may, however, be useful for assessing iron status or setting broad therapeutic targets in large patient populations. Day of the week effects are minimal for Hb and Hct, and undetectable for other analytes.

“The advantages inherent in directly assessing immature cells are potentially under-recognized. The publication of this study supports

our belief that the advantages of direct cellular analysis versus indirect assumptions on iron status [storage or transport protein measurement, serum iron, or algorithms] may well be a means of refining complex anemia treatment decisions,” said Ian Giles,

M.D., Director of Scientific Affairs, Sysmex America, Inc.

The study poster was presented at the recent 2009 National Kidney Foundation Spring Clinical Meeting held in Nashville, TN and attended by nearly 2,500 attendees including physicians, fellows and residents, physician assistants, nurse practitioners, nurses and technicians, renal and clinical dietitians, and social workers.

About DaVita Inc.DaVita Inc., a FORTUNE 500® company, is a leading provider of kidney care in the United States, providing dialysis services and education for patients with chronic kidney failure and end stage renal disease. Recognized as the only FORTUNE 500® company on WorldBlu’s annual List of Most Democratic Work Places™, DaVita manages more than 1,475 outpatient facilities and acute units in more than 700 hospitals located in 43 states and the District of Columbia, serving approximately 114,000 patients – nearly one-in-three of all dialysis patients in the United States. As part of DaVita’s commitment to building a healthy, caring community, DaVita develops, participates in and donates to numerous programs dedicated to transforming communities and creating positive, sustainable change for children, families and our environment. For more information about DaVita, its kidney education materials and its community programs, please visit www.davita.com.

DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He) Parameter

RET-He Parameter Demonstrates Potential Value as an Indicator of Anemia Treatment Decisions for Physicians in ESRD Patients on Hemodialysis.

David Van Wyck, M.D., Vice President of Clinical Affairs, DaVita Inc., and Emeritus Professor of Medicine

and Surgery at the University of Arizona College of Medicine, in Tucson (center) is seen here discussing

the DaVita study poster with colleagues at the annual National Kidney Foundation meeting. The DaVita

study identified Sysmex’s Reticulocyte Hemoglobin Equivalent (RET-He) parameter result as key input

used by physicians to assist in Anemia treatment decisions in ESRD patients on hemodialysis.

1. DaVita is a registered trademark of DaVita, Inc. All other trademarks are the property of their respective owners.

RET-HeRET-He is an established parameter in the National Kidney Foundation’s KDOQI (Kidney Disease Outcomes Quality Initiative) guidelines for assessing the initial iron status of patients with chronic kidney disease on hemodialysis as well as IV iron replacement in these patients. The Sysmex XE-5000, XE-2100 and the XT-2000i Automated Hematology Analyzers provide the RET-He parameter, which quantifies the hemoglobin content of reticulocytes. Sysmex technology uses proprietary polymethine dyes that have an affinity to, and fluorescently label, nucleic acids. Detection and characterization of immature cells may well be a more valuable approach than measuring storage or transport proteins, serum iron, or algorithms which incorporate indirect assumptions.

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Sysmex recently exhibited at the AACC/ASCLS 2009 Clinical Lab Expo held July 21-23. More than 17,000 people converged at the McCormick Place in Chicago, IL to see the latest offerings for the clinical laboratory products and services.

Sysmex showcased our Lavender Top Management® powered by Intelligent Automation Solution, among other products. Photos of the booth are shown below.

RECYCLE ◆ REUSE ◆ REPLENISH

SYSMEX AMERICA, INC.One Nelson C. White Pkwy.Mundelein, IL 60060

Sysmex Partners with Third Largest Commercial Laboratory in the US Sysmex America and BioReference Laboratories (BRLI) recently announced a five-year sole source agreement. Vendor selection was based, in part, on feedback from BRLI’s administration, pathologists, laboratory professionals and the company’s purchasing department.

“As an existing clinical laboratory customer, the reliability of Sysmex hematology instruments and services is well known to us. As such, BioReference Laboratories wanted to extend its current working relationship with Sysmex to include its Intelligent Automation Solution. This solution will enable us to maximize our testing capacity, minimize human intervention; improve results turnaround time and enhance the overall efficiencies of our laboratory operations,” said Warren Erdmann, Senior Vice President and Director of Operations, BioReference Laboratories, Inc.

BioReference Laboratories’ purchases include three HST-N Hematology Automation Systems comprised of XE-Series Automated Hematology Analyzers, Sysmex SP-1000i Automated Slidemaker/Stainers and Sysmex-distributed DM96 Automated Digital Cell Morphology Systems. Sysmex WAM decision logic software will bring rules-based intelligence to these automation systems by consolidating data from the multiple instruments and performing expert rules-based functions and results management. The HST-N systems are linked to a sample sorter archive.

BioReference Laboratories’ Sysmex Intelligent Automation Solution will enable hands-free hematology testing, slide making and staining, sorting, archiving, repeat testing and decision processes; while achieving the highest throughputs within one of the industry’s smallest footprints. BioReference will also benefit from the XE-5000’s body fluid analysis applications, which includes a differential for all fluids.

“We are pleased that Sysmex America’s hematology products and

services have met BioReference Laboratories’ performance standards. We look forward to being a part of their growth as the company continues to lay the groundwork for a sustainable future,” said John Kershaw, President and CEO, Sysmex America, Inc.

“By standardizing instrument platforms, information integration, and advanced technologies, laboratories can achieve unparalleled levels of optimization for laboratory operations that literally transform their productivity – all of which offer the enormous benefit of standardized care and consistency,” said Kershaw.

BRLI is the third largest full service laboratory in the United States and the largest independent laboratory in the Northeastern

U.S. It is primarily a clinical testing lab servicing physician offices with concentrations in the focused markets of esoteric testing, molecular diagnostic, anatomical pathology and correctional health care.