Synthetic Bone Graft

Agenda

1. Company Profile2. Business Areas3. Types of Bone Graft4. Products5. Indications6. Advantages

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Especialist in Bone Repair and Regeneration

Established since 2008, Medbone® develops and manufactures high quality medicaldevices in the area of bone regeneration, using an innovative and patentedtechnology.

Our medical devices are sold in national and international markets and are used inthe dental, orthopedic and in veterinary surgery.

Medbone - Biomaterials

Mission

Develop and manufacture

HIGH QUALITY medical devices

Offer INNOVATIVE tools to healthcare

professional

IMPROVE the patients quality

of life

Certification

Medbone® is certified by the ISO 9001 and ISO 13485. All our productsare certified by the European Directive 93/42/EEC.

R&D Pipeline*

Taking into consideration the internationalization and constant growth of thecompany, Medbone® early invested in the development of products.

We seek to provide a constant response to the growing needs of the healthcareprofessionals.

* All the industrial property of Medbone is protected.

Business Areas

Examples:Hip Osteotomy Knee Osteotomy Extremities Bone CurettageEtc.

Examples:Broken limbs

Examples:SpineBrain surgery

Examples:ImplantsSinus Lifting

Examples:MaxillofacialSurgeries

Bone Graft

Bone Graft is intended to be used as a bonevoid filler, being applied to repair bonefractures or bone defects that are complexand fail to heal properly.

The ideal Bone Graft

OSTEOCONDUTIVE

OSTEOINDUCTIVE

BIOMECHANICALLY STABLE

DEGRADE WITHIN AN

APPOPRIATE TIME FRAME

RESORBABLE

OSTEOGENIC

BIOCOMPATIBLE

Bone Graft should be:

Bone grafting requires the interation between:

OSTEOINDUCTION OSTEOCONDUCTION

Biocompatible materialthat provides a physicalstructure into and alongwhich bone may grow.

Process that involvesthe stimulation ofosteoprogenitor cellsto differentiate intoosteoblasts that thenbegin new boneformation.

OSTEOGENESIS

Physiological processby which new bone isformed.

Bone Grafting

Allograft: collected from eitherliving donors or nonlivingdonors and must be processedwithin a bone tissue bank.

Autograft: Bone obtainedfrom the same individualreceiving the graft.

Xenograft: Bone from aspecies other than human,such as bovine/porcine bone.

Synthetic Bone Graft: composedof biocompatible calciumphosphate materials that aresimilar to that of bone andcapable of bonding chemically tobone.

Types of Bone Grafts

ADVANTAGES DISADVANTAGES

The Gold Standard in bone substitution

Osteoinductive

Osteoconductive

Osteogenic

No potential for disease transmission orimmunogenic response

Limited availability and surgery time

Second site surgery to obtain the graft

Morbidity in the donor site

Post-operative pain and complications

Need to recover the extraction site

Autograft

ADVANTAGES DISADVANTAGES

Available in various geometric and shapeable forms

Osteoconductive

Cortical allografts may provide structural supportand may be immediately load bearing

Potential for disease transmission and immune rejection

Variable clinical results and inconsistent graft incorporation

Freeze-dried allografts have low compressive strength

Price (€€€€)

Higher availability

Weakly Osteoinductive (if growth factors remainafter processing)

Risk of cross-contamination with bovinespongiform encephalopathy or porcineendogenous retroviruses (xenograft)

Reduced healing time

Allograft / Xenograft

ADVANTAGES DISADVANTAGES

Demineralized bone matrix (DBM)

Inherent osteoconductive

Moldable and adaptable material

Different properties due to the large variability of donors used to harvest the graft

Weak Mechanical resistance

Potential for infectious disease transmission

Price (€€€€)

Higher osteoinductive potential than the allografts

Reduced healing time

DBM bone tissue (from animal or bone bank origin) that has had theinorganic mineral removed, leaving behind the organic "collagen" matrix.

ADVANTAGES DISADVANTAGES

Synthetics

Osteoconductive matrix with a long clinical history

Absence of toxicity, disease transmission and immunogenicity

Less associated pain, blood loss and post-operative complications

Lack of osteoinductive or osteogenic potential

Brittle (in certain cases)

Typically used in non weight bearing applications

Bioactivity, , biodegradability, long shelf-life

Unlimited availability in different shapes, porosities and compositions

Products

COMPOSITION POROSITY

RESORPTION PERIOD

- 100% Synthetic- 25 % TCP + 75% HAp

- 80%- Pore Size : 300 – 500 microns

- 6 to 24 months

COMPOSITION POROSITY

RESORPTION PERIOD

- 100% Synthetic- TCP

- 80%- Pore Size : 300 – 500 microns

- 1 to 6 months

Several Geometries

Granules

Geometric Shapes

Vertical augmentation

Implantology

Maxillary sinus lift

Horizontal augmentation

Alveolar regeneration

Maxillofacial Osteotomy

Maxillofacial & plastic surgery

Peri-implant regeneration

Indications

Main Advantages No risk of infection

High availability

Avoids the painful Autograft removal

Radiopaque, allow the monitorization by a simple X-Ray

Works as atemporaryimplant once isfully reabsorbeand substituteby new bone

There are no bone density differences

between the new formed bone and the

remanant bone

Surgery time reduction

No immunological

risk

Why choose adbone®?

Exceptional Biocompatibility

Extremely Osteoconductive

Excellent Resorption Rate

High Mechanical Resistance

Several Geometries

Custom Made Implants