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Syllabus Information: Genetics BIOL 3313. Dr. David F. GilmoreOffice: 418 LSE Email: [email protected] Web page: http://www.clt.astate.edu/dgilmore Office hours: TBA; other times by appt. Syllabus info (continued). Four lecture exams (100 pts each) - PowerPoint PPT Presentation
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1Syllabus Information: Genetics BIOL 3313
Dr. David F. Gilmore Office: 418 LSE• Email: [email protected]
• Web page: http://www.clt.astate.edu/dgilmore • Office hours: TBA; other times by appt.
2Syllabus info (continued)
• Four lecture exams (100 pts each)• Fifth exam at Finals time (100 pts)• Additional points for homework, quizzes, other
assignments.
Attendance sheet
These PowerPoints: Note number, take scant notes; slides will be posted before class.
3Genetics:
the Study of Biological Information• How is the information stored/organized?
• How is it used?
• How is it transmitted to new generations?
• How is it distributed among populations?
4Genetics:
the Study of Biological Information
• How is the information stored?
• How is it used?
• Look at the information storage molecule itself.
• Look at how the information is processed and the products of that information.
5Genetics: the Study of Biological Information
• How is it transmitted to new generations?
• How is it distributed among populations?
• Look at how information is passed on at the cellular level and what info shows up in the offspring.
• Look at patterns of inheritance in families, quantify how traits persist and are distributed within populations.
64 Major Divisions/Approaches in Genetics
Classical genetics: look at patterns of inheritance, note how genes act by observing inherited characteristics.
Molecular genetics: Reductionist approach, determine how genes work by examining and manipulating their molecular structure.Population genetics: Use of statistics and math to see how traits are passed on, maintained, or lost among large numbers of individuals.
Cytogenetics: learning about inheritance by studying cell structures, particularly chromosomes.
7A Book on How to Make Gargoyles: An analogy about genetic information
8A Book on How to Make Gargoyles: An analogy about genetic information
Questions about the book itself: color, weight, # of pages?
Book as source of information: organization? Number of chapters?
Information independent of book
9A Book on How to Make Gargoyles: An analogy about genetic information
Phenotype vs. genotype: what’s on your friend’s roof?
Vertical vs. horizontal transmission: who gets a copy of the book?
10Using genetic information:the “central dogma”
Proteins can be directly responsible for traits.
Enzymes (proteins) can create traits:metabolize sugars; synthesize pigments or vitamins; assemble other informational macromolecules like polysaccharides.
11Lipids
• Fatty acids, phospholipids, cholesterol, steroid hormones, etc.– Hydrophobic; components of membranes, can diffuse
through membranes• Steroid hormones bind to receptors with specificity
– Result in changes in gene expression– Have information content, change information usage
www.pandasthumb.org/archives/images/lock&key.jpg
12Carbohydrates
• Simple sugars, oligosaccharides, polysaccharides– Polysaccharides include
structural/storage materials such as starch, cellulose, peptidoglycan, glycogen, chitin.
– Some oligosaccharides (on glycoproteins, glycolipids) have specific, complex structures:
– Information contentwine1.sb.fsu.edu/BCH4053/Lecture15/Lecture15.htm
13Proteins
• Sequence of amino acids determines eventual 3-D structure.
• Sequence itself directly coded for by DNA
• Proteins have high degree of information content.
http://www.cs.nott.ac.uk/~nxk/TEACHING/G6DHLL/COURSEWORK/2003-2004/courseworks_files/image009.gif
14Nucleic acids
• The ultimate informational molecules
• Genetic information determined by sequence of nucleotide bases.
http://www.fhcrc.org/science/education/courses/cancer_course/basic/img/dna.gif
15Review of Cell Structure
• Eukaryotes: larger, and compartmentalized– Feature membrane-bound organelles– DNA enclosed in nucleus, associated with histones
• Capable of being tightly packaged• Prokaryotes: small and structurally simple
– Membrane-bound organelles lacking– DNA loosely packaged with histone-like proteins
• Never tightly packaged• Attached to inside of cell membrane
16Eukaryotic cell surface features• All cells have a phospholipid/protein bilayer membrane,
the interface between the cell and its environment.• The cell coat consists of
informational molecules: polysaccharides and PS-containing lipids and proteins.
These molecules act as receptors to identify the cell or receive messages that trigger changes in gene expression. Green: proteins; blue: PS; red: lipids.
http://www.sju.edu/biology/CellsPowerPt/chp11/img030.jpg
17The Nucleus and CytoplasmOrganelle with a double membranePores allow passage of materials.
DNA packaged with proteins = Chromatindiffuse, granular apperance.
Nucleolus: rRNA and ribosome synthesis
137.222.110.150/ calnet/cellbio/page4.htm; http://www.sp.uconn.edu/~bi107vc/images/cell/cytoplasm.gif
Cytoplasm is a colloid of protein and water
Contains the other organelles and membrane systems such as endoplasmic reticulum and the ribosomes, site of protein synthesis.
18More organelles• Ribosomes, endoplasmic reticulum, and Golgi work
together to create and distribute proteins– After synthesis on ribosomes, proteins acquire sugar tags in ER
and are sorted and shunted after being prepared in Golgi.• Ancient endosymbionts
– Mitochondria resemble Gram negative bacteria (2 membranes) in many ways, are self replicating and have own DNA
• Site of aerobic respiration, ATP synthesis• DNA is circular like bacterial; bacterial-type ribosomes.
– Chloroplasts similar and carry out photosynthesis; have own DNA
19Centrioles and cytoskeleton• The centrioles are structures that occur in
pairs and are made of microtubules.– Microtubules are made of protein– Centrioles help assemble the spindle to which
chromosomes attach in mitosis.• The cytoskeleton is made of microtubules
and microfilaments– Proteins are generally tubulin or actin– Provides cell shape, structure and locomotion.
cell.sio2.be/noyau/4.php ; www.cellsalive.com/ cells/cytoskel.htm
20Prokaryotes• No organelles, little or no cytoskeleton• Cell wall surrounding cell membrane,
so membrane surface not heavily involved in receiving signals.
• Small size and lack of nucleus allow rapid responses to changes in the environment.
• Ribosomes plentiful, but smaller and different from eukaryotic.
http://ghs.gresham.k12.or.us/science/ps/sci/soph/cells/pics/pro1.jpg