Swiss Life Sciences Trend Analysis 2015

About Us

The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com

The Swiss Life Sciences Database is a part of the global Biotechgate and is brought to you in partnership with the Swiss Biotech Association, BaselArea and Life Sciences Zurich / Canton of Zurich. www.swisslifesciences.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Overview of the Swiss Life Science Industry

2015 Statistics

Total Biotech Companies 343

Medtech companies 231

Pharma companies 47

Investor companies 40

Public / Non-Profit Organizations / Medical Facilities 194

Other life science related companies 888

Percentage of Publicly Owned Companies 4%

Biotech Venture financing 2013 / 2014 USD 196m / USD 321m

Life Sciences Venture Financing 2013 / 2014 USD 267 m / USD 420m

Number of Technologies 205

Licensing Opportunities 136

Number of Employees

1-1029%

11-5023%greater than

20021%

51-20027%

Number of employees - Life Sciences

1-1031%

11-5033%

greater than 2008%

51-20028%

Number of employees - Biotech sectors

Company Ownership

Private / independent

74%

Public4%

Subsidiary22%

Biotechnology companies by ownership status

Private / independent

73%

Public4% Subsidiary

23%

Life Science companies by ownership status

Overview of the Swiss Biotechnology Industry

2014 Statistics 2015 Statistics

346 Total Biotech Companies 343

101 Biotech - Therapeutics 100

172 Biotech - R&D Services 171

73 Biotech - Other 72

94% Percentage of SME's 89%

4% Percentage of Publicly Owned Companies 4%

USD 325m (2013) Venture Financing/Capital Raised USD 321m (2014)

100 Licensing Opportunities 136

Company Foundation Timeline

0

5

10

15

20

25

Number of Biotech Companies Founded by Year

Therapeutics and Diagnostics R&D Services Biotech - other

Key Activities of Biotechnology Companies

AgroBio2%

Bioinformatics and Bioelectronics

5%

Contract Research and Manufacturing

12% Cosmetics5%

Diagnostics and Analytical Services

18%

Drug Delivery3%

Environment1%

Food and Nutraceuticals5%

Genomics and Proteomics

5%

Industrial Biotechnology1%

Other Services and Suppliers

24%

Therapeutics17%

Veterinary2%

Key Biotech Activity

Biotech Products - Breakdown by Indication

0 10 20 30 40 50

Neoplasms / cancer / oncology

Diseases of the nervous system

Infectious and parasitic diseases

Cardiovascular

other

Genitourinary system

Endocrine, nutritional and metabolic diseases

Diseases of the eye

Skin and subcutaneous tissue

Musculoskeletal system and connective tissue

Mental and behavioural disorders

Respiratory

Diseases of the blood and blood-forming organs; …

Digestive system

Conditions originating in the perinatal period

Biotech Producs by Indication

Products in the Pipeline – 4 years report

0 20 40 60 80 100 120 140

Phase III

Phase II

Phase I

Preclinical

11

61

44

105

14

53

41

85

25

49

53

115

14

45

41

123

Number of Biotech Products in Development

2012

2013

2014

2015

Biotechnology Financing in Switzerland – 5 year report

2010 H1 2010 H2 2011 H1 2011 H2 2012 H1 2012 H2 2013 H1 2013 H2 2014 H1 2014 H2 2015 H1*Financing

Value 47 49 116 104 14 94 81 238 145 176 102

Number of Rounds 4 5 10 3 10 7 12 15 17 7 7

0

2

4

6

8

10

12

14

16

18

0

50

100

150

200

250

Num

ber o

f Rou

nds

Fina

ncin

g Va

lue

(Mill

ion

USD

)

Venture Financing of Biotech Companies

* Until May 2015

Major Biotech Financing Rounds (H2 2014 – H1* 2015)

Company Sector USD M

Molecular Partners AG Biotech – Therapeutics & Diagnostics 97.4

Biocartis SA Biotechnology - R&D Services 78.7

CRISPR Therapeutics Biotechnology - R&D Services 64

Auris Medical AG Biotech – Therapeutics & Diagnostics 56

* Until May 2015

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The “Swiss Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof.

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