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Sweet’s Syndrome. David Deneau MD Acute Neutrophilic Dermatosis (Sweet RD. Br. J. Dermatol.1964; 76:349-56). Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Clinical Features - PowerPoint PPT Presentation
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Sweet’s Syndrome
David Deneau MD
Acute Neutrophilic Dermatosis
(Sweet RD. Br. J. Dermatol.1964; 76:349-56)
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s SyndromeClinical Features
• Tender to painful red plaques face, hands, arms, upper trunk
• Acute onset• Frequently associated with;
PMN leucocytosis
Fever
Arthralgias
Malaise
Sweet’s Syndrome
Histology• Diffuse neutrophilic infiltrate in upper dermis • Leucocytoclasis• Without evidence of primary leucocytoclastic
vasculitis
Sweet’s Syndrome
Associated Disorders
50% cases are idiopathic
50% may be associated with underlying disease
• Malignancy (20 – 25%)
Leukemia
Lymphoma
Carcinomas
Sweet’s Syndrome
Associated Disorders, (continued)
• Infection: Streptococcal URIYersinial GI infection
• Pregnancy
• Inflammatory Bowel Disease
Sweet’s Syndrome
Associated Disorders (continued)
• Drug Reactions: G-CSF
Minocycline
Trimethoprim – Sulfamethoxazole
all – trans Retinoic Acid
Oral Contraceptives
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Sweet’s Syndrome
Treatment
• Systemic corticosteroidsUsually dramatic response4-6 week tapering courseRelapse may occur
• ColchicineMay be effective in mild disease
Sweet’s Syndrome
Treatment (continued)
• Potassium iodide• Indomethacin• Dapsone• Cyclosporine• Tetracycline type antibiotics