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Surgical Management of Inflammatory Bowel Disease. Sandra J Beck, M.D. University of Kentucky Assistant Professor of Colon & Rectal Surgery. Surgical Management of IBD. Goal:Improve Quality of Life Curative? Treatment of Complications Palliation of Symptoms. Surgical Management of IBD. - PowerPoint PPT Presentation
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Surgical Management of Inflammatory Bowel Disease
Sandra J Beck, M.D.
University of Kentucky
Assistant Professor of Colon & Rectal Surgery
Surgical Management of IBD
• Goal: Improve Quality of Life– Curative?
– Treatment of Complications
– Palliation of Symptoms
Surgical Management of IBD
Therapeutic goals vary for different types of IBD
Inflammatory Bowel Disease
• Classification– Ulcerative Colitits
– Crohn’s Disease
– Indeterminate Colitis
Normal Anatomy
Ulcerative Colitis: Course and Prognosis
• Prognosis much improved over last half century– Improved medications– Advances in surgical technique– Better peri-operative care
• After 10 years of disease, colectomy rate = 24%• Maintenance of ability to work after 10 years of
disease = 93%Langholz E, et.al. Gastroenterology 1994;107:3
Surgical Management of Ulcerative Colitis
• Goals:– Cure disease
– Improve quality of life—relieve symptoms
– Prevent risk of carcinoma
• Indications– Toxic colitis
– Hemorrhage
– Medical intractability
– Malignant degeneration (cancer, dysplasia)
Surgical Management Ulcerative Colitis
• Options– Total Abdominal Colectomy, end
ileostomy
– Total proctocolectomy, end ileostomy
– Total proctocolectomy, ileal pouch anal anastomosis
Surgical Management of Ulcerative Colitis
Total Abdominal Colectomy, End Ileostomy• Used for urgent/emergent indications
– Toxic colitis– Toxic Megacolon + perforation– Hemorrhage– Intractable disease in “unhealthy” patients
• May be used when classification of IBD is uncertain
Total Abdominal Colectomy with End Ileostomy
Total Abdominal Colectomy, End Ileostomy
Advantages
• Can be expeditiously performed
• Avoids pelvic dissection
• Allows for a large specimen for pathologic evaluation
• Allows patient to discontinue drug therapies
Disadvantages
• Not a definitive operation
• Rectum may remain symptomatic
• Pathologic overlap in toxic state
• Delay necessary before next surgical step
Surgical Management of Ulcerative Colitis
Total Proctocolectomy, End Ileostomy
• Curative
• Relatively uncomplicated
• High patient satisfaction
• Benchmark procedure for UC
• Permanent Ileostomy
Total Proctocolectomy, End Ileostomy
• Indications– Poor anal musculature / fecal incontinence– Suspicion of Crohn’s disease (i.e. perianal disease,
small bowel disease)– Rectal cancer – Patient request
• Technique– Abdominal proctocolectomy– Intersphincteric perineal dissection– Brooke Ileostomy
Total proctocolectomy with end ileostomy
Surgical Management of Ulcerative Colitis
Total Proctocolectomy, Ileal pouch anal anastomosis• Curative• Relatively uncomplicated• High patient satisfaction• Maintains intestinal continuity• Most common surgical procedure performed today
for ulcerative colitis
Total Proctocolectomy, IPAA
• Patient Selection
• Functional Outcome
• Complications
• Overall Results
Total Proctocolectomy, IPAA
• Patient Selection– Certainty of diagnosis
– Adequate anal function
– Acceptable medical risk
– Informed and motivated patient
Total Proctocolectomy, IPAA
• Adequate anal function– Can be determined by history, examination, and
manometry– Both sutured and stapled pouch surgery leads to
a decline in resting and squeeze pressures– Patients who are continent preoperatively tend
to remain continent postoperatively
Churh J, et.al. DC&R 1993;36:895
J-Pouch with Temporary Ileostomy
J-Pouch Anal Anastomosis(with Ileostomy closed)
Function after IPAA
• BM’s per day = 5 to 7
• Continence = 65-90%
• Seepage = 10%
• Overall quality of life rated excellent by 90% of patients
• Now have 25 year data
Complications of IPAA• Overall morbidity rate decreasing with increased
experience with procedure• Anastomotic leak—10-14%• Intestinal Obstruction–16-19%• Pouch-anal, Pouch-vaginal fistulae• Anal stricture--8-14%• Pouchitis—20%
– More common in UC patients than FAP patients– Overall long term incidence may be 50%
• Pouch failure rate overall= 2%
Surgical Management of Crohn’s Disease
Surgical Management of Crohn’s
• No medical or surgical cure for Crohn’s at present
• Surgery generally reserved for patients with complications of the disease or for patients whose quality of life is adversely affected by medical management
• Specter of recurrence is always present
Surgical Management of Crohn’s
• Indications – Abscess– Fistula– Perforation– Obstruction– Extraintestinal Manifestations – Presence or Risk of Malignancy
Surgical Management of Crohn’s
• Most patients require one or more operations– Probability after 20 years = 78%– Probability after 30 years = 90%
Nat’l Coop. Crohn’s Disease Study Gastroenterology 1979
• Ileocolic disease is most common and most likely to eventually require surgery– 90% at 10 years of symptomatic disease
Surgical Management of Crohn’sGuidelines
• Disease is chronic; keep long term outlook for patient in mind
• Preserve small bowel whenever possible
• Treat only the primary problem
Surgical Management of Crohn’sTypes of Operations
• Intestinal resection with or without anastomosis
• Bypass procedures– Internal-e.g. gastroduodenostomy – External-e.g. ileostomy
• Stricturoplasty
Resection
• Most common operation for Crohn’s• Usually initial procedure of choice for small
bowel disease• Procedure of choice for colitis as well
– Segmental colon resection– Total colon resection
• 50% will require another operation within 15 years
Resection with Handsewn Anastomosis
Resection with Stapled Anastomosis
Specific Anatomic Presentations
• Ileocolic
• Small Bowel
• Segmental Colon
• Entire Colon
• Perianal Disease
Ileocolic Crohn’s• Distal Ileum
– Most common presenting site– Often involves cecum (40%)– Management consists of ileocolic resection
with anastomosis• End-to-End or End-to-Side anastomosis have equal
rates of recurrenceCameron J, et.al. Ann Surg 1992;215:546
• End-to-Side or Side-to-Side anastomosis have equal rates of recurrence
Scott N, Sue-Ling H, Hughes L. Int J Colorect Dis 1995;10:67
Ileocolic Disease: Special Circumstances
• Sparing of Ileocecal Valve– Need 5-7cm of normal ileum proximal to valve to
preserve
– End-to-End anastomosis generally preferred
• Ileal disease with proximal skip lesions– Need to be concerned with short bowel syndrome
– Options• Resection with one anastomosis
• Multiple resections with multiple anastomosis
• Resection in conjunction with stricturoplasty(ies)
Stricturoplasty
• Indications– Multiple short segment strictures– Recurrent disease in patients with history of
resection(s)– Rapid recurrence of disease manifested as
obstruction– Stricture in a patient with Short Bowel
Syndrome
Stricturoplasty
• Contraindications– Free or contained perforation of small bowel– Internal or external fistula involving affected
site– Multiple strictures in a short segment– Stricture close to area planned for resection– Colonic strictures– Low albumin or protein level
Stricturoplasty
• Heineke-Mikulicz– Employed for strictures < 10 cm– Extend longitudinal enterotomy 2cm beyond
stricture in either direction– Close enterotomy transversely
• Finney Stricturoplasty– Used for longer strictures– Resection probably superior
Strictureplasty
Stricturoplasty
• Results– Morbidity low- 15%
• Sepsis• Hemorrhage
– 98% of patients relieved of obstructive symptoms
Fazio V, et.al. DC&R 1993;36:355
– 28% reoperative rate• 78% of these for remote disease (stricturing or
perforative)Ozuner G, FazioV. DC&R 1996;39:1199
Colonic Crohn’s
• Segmental Disease– Value of segmental colon resection
controversial– Preservation of colon decreases diarrhea,
avoids use of ileostomy• 62-67% of patients have recurrent colitis
• >80% are able to preserve bowel continuityLongo W, et.al. Arch Surg 1988;123:588
Crohns Colitis
Crohns Colitis
Crohn’s Colitis
• Extensive disease precludes segmental resection
• Proctocolectomy with end ileostomy procedure of choice
Crohn’s Colitis
• Subgroup of patients with extensive disease have anorectal sparing and adequate continence
• Abdominal colectomy with ileorectal anastomosis– 50% of patients eventually
require rectal excision at 20 years
– Only 1/3 of patients are “content”
Perianal Crohn’s• Clinical Features
– Edematous skin tags– Blue discoloration– Fissures or ulceration– Abscesses– Fistulae– Anorectal stricture
• Patients with colonic disease more likely to have anal disease– 52% vs. 14% with small bowel disease
Crohns Anal Fissure
Crohns Anal Abscess
Perianal DiseaseTreatment
• Individualized to each patient• Goals
– Ameliorate symptoms
– Prevent complications
• Goals need to be met without impairing continence
• Generally medical management preferable with limited surgical intervention when necessary
Perianal DiseaseTreatment
• Effect of proximal disease on perianal disease– Multiple studies with conflicting results– Beyond adolescence there is no compelling
proof that treatment of proximal disease lessens perianal disease
– Treat proximal disease independently
Crohns Perianal Disease
• Control sepsis with drains or setons
• Injection of steriods
• Diversion of fecal stream
• Excision of Anus and Rectum and Permanent Colostomy
Drainage with Seton
Questions?
Questions??