Supplementary Figure S2: HBV whole genome, BCP, C, P, PreC ... · Supplementary Figure S2: HBV whole genome, BCP, C, P, PreC, PreS1, PreS2, RT, S, X QS at nucleotide level (A) and

Supplementary Figure S2: HBV whole genome, BCP, C, P, PreC, PreS1, PreS2, RT,

S, X QS at nucleotide level (A) and amino acid level (B), genetic distance at

nucleotide level (C) and amino acid level (D), dS (E) and dN (F) based on CBS and

TGS data. Red points represent the characteristics of QS of each patient for CBS.

Blue points represent the characteristics of QS of each patient for TGS. (*, P<0.05)

CBS TGS

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CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS

CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS

CBS TGS

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CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS

CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS CBS TGS



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C P PreC PreS1 PreS2 RT S X

Genome BCP C P PreC PreS1 PreS2 RT S X

Genome BCP C P PreC PreS1 PreS2 RT S X




Com

plex

ity(n

t)C

ompl

exity

(aa)

dist

ance

(nt)

dist

ance

(aa)

dSdN

*

* *

* *

*

A

B

C

D

E

F

Documents

Supplementary Figure S2: HBV whole genome, BCP, C, P, PreC ... · Supplementary Figure S2: HBV whole genome, BCP, C, P, PreC, PreS1, PreS2, RT, S, X QS at nucleotide level (A) and