0.1

YbtMT

LkcKS1

TaKS11

BTKS3 ?

TaKS12

0.87

DifKS13

DifKS1

BaeKS12

BaeKS8

DifKS6

1.00

OnnKS6

PedKS61.00

PedKS1

OnnKS10.95

0.99

0.94

BTKS14

MmpKS5

MmpKS71.00

1.00

ChiKS2

ChiKS13

ChiKS3

DszKS20.96

0.95

ChiKS8*

ChiKS17

LnmKS5

ChiKS140.90

0.98

0.74

0.98

S-PKS

O

CH3

R

R S-PKS

O

CH3

S-PKS

O

CH3

R

S-PKS

O

R

OH

CH3H3C

S-PKS

O

CH3

R

OH

S-PKS

O

CH3

R ?

S-PKS

O

CH3

R

OH

S-PKS

O

R

OH

CH3H3C

S-PKS

O

CH3

R

Supplementary figure 1: Bayesian cladogram of MT domains

The MT from the yersiniabactin cis-AT PKS-NRPS system was used as outgroup. Probabilityvalues larger than 0.6 are shown at the nodes. Methylated products as deduced from knownpolyketide structures are shown besides the clades. Abbreviations see Fig. 3 legends. The positionof the MT within the PKS is specified according to the KS domain of the same module, e.g, LkcKS1is the lankacidin MT domain within the module that contains the first KS (counted from theupstream end of the gene cluster). The MT in ChiKS17 is inactive.

Supplementary figure 2: (a) HPLC trace at 317 nm of an extract of a B. thailandensis culture. (b) UV spectrum of thailandamide A (16).

190 290 390 490 590

UV length

Ab

so

rba

nc

e

0 10 20 30 40 50 60Time (min)

absorb

ance

at

31

7

nm

16

17

(b) (a)

HN

OH

HOOH O

O OH OMe O

HN

OH

HOOH O

O OH OMe O

Thailandamide A (16)

11020

30 5

1525

Supplementary fig. 3: Key 1H-1H COSY (bold lines) and HMBC (arrows)correlations of thailandamide A (16).

Supplementary data 1: Sequences of trans-AT PKS proteins with conserved motifs highlighted in yellow (KS), green (DH), blue (KR), grey (MT) and purple (ACP). Bacillaene (B. amyloliquefaciens) BaeJ AL PCP C A PCP KS1 DH KR ACP ACP KS2 KR ACP (KS3) MKSDMKASGLLKPSVSYGKSLRLSADQPMTIPEVLHKTAAAAGDQKGITYIQPDGTKVYQTYSSLKKIALSIVKGLRQSG VKAQDEVILQLSDNSQLIPAFWGCVFLGAIPVPLAAAPAYTEMNSGTQKLKDAWTLLNQPYVITSRDVLPEMTEWAEEQG LSGFCALAAEDLSAHEMDTDCHHPRPEDLAMLLLTSGSTGTPKAVMLSHENIVCMVKGNIQMQGYTSEDVTFNWMPFDHV GGIGMLHLRDVYLGCEEINIPSESILMDPLKWLDLIDHYRASVTWAPNFAFGLLADFAEEIQTRKWDLSSMRYMLNGGEA AVAKVGRRIMELLEPHGLPANAIRPAWGMSETSSGVIFSDEFTLENTNDDDRFVEIGLPIPGFNMRITDDRNQVVEEGEI GRFQVSGLTVTSGYYERPDLNESVFTEDGWFETGDLGFLREGRLTITGRTKDAIIINGVNYYSHAIESAVEELPEIETSY TAACAVRPNQSTTDELAIFFVTSVPLDENRMTKLLHHIHQHVTQRIGVTPDYLLPVAKEDIPKTAIGKIQRTQLKHSFEQ GQFDSLHNNRQEGGNSDTASAEKEIERDFIRFLKEELSIAEELVDPNTPFQSLGVNSIKMMKLARSIEKTYHIRLTAREL HKNPTIGALAAYTAEKAANMSAEHHPQKAEPPAERERRQTAPALSEVQKGLWTLQKMSPETTAYHVSLCFRFTSGIDKEK LKQAFQLVLKQHPMLKSAVNETDGGFYFIEAADPFVFSEEDISDVNETQISALIRKKVKEPFVKEGGPLLRVQLLSKSAE EHYLLTVIHHIVFDGISSITFIHSLLDHYQALLEGKEEFTAAAPGIHPDFAAWEKRYLAGDESKAARAYWMKQLEGDLPD LQLPPMRTDSSVPEFTEDTLTRRLPERLLNNITAFAASRSIHLSTVMLSCYMVLLSKYTDKEDIVTGMPAMVRPEERFDG VVGHFLNMLPIRSRAGRKETFADFVQKVQDAVLDGLDHSFYPFPKMVRDVHAKPLQNGSPVFSNAFFYQNFLQHSSYQSM LDEYKEFSCEFVKDIHQEGEYDLVFEMWEEASGMDLTIKYSTELFDEAGAARLFSQFVQAAEALTANPDTPLENVSLMTK REEHMILKTWNETSREYPDACFHELFERQAAETPDACAVVYEQQQLTYRELDEKSTKLALYLQAHGAGPDDLIGIYTDRS LHMAVGLLGILKAGGAYVPLDPSYPADRLEYMIADSRISMCLTTADLEHSLNWGGVQTTAIDRDWSHIESTAAERTSLKR LVTPDDLAYVIYTSGSTGKPKGVMIPHRALTNFLISMANEPGLSSEDKLLAVTTYCFDIAALELYLPLIKGAECNICKTE VTKDARKLKELIQEYKPTIMQATPFTWKMLFHSGWSNEENVKILCGGEALSEQLKQQFLDTKSEAWNMFGPTETTIWSAV QRITENESALTIGRPIANTRVYIMDSGLNPVLEGVPGELCIAGDGLARGYFNKPELTDKAFVSHRLELGSKLYKTGDMAR FLPGGRIEYMGRMDTQVKIRGYRIEPGDIESRLNAHPAVQESVVVVNNHSGNEKLCAFYIRKNGEPLPSAKELRKHMKQA LPAYMAPASFVRLEELPLTPNGKVDRKLLAARDLTEKQPDTQTFSSSHIQQAVLAIWQDVLKSKDIELDDRFFDAGGDSL LAVTVTDRMTQELDCEFSVTELFEYATVKDISRYITEQKPKEAFLAPVPQKKVNAEDREHPAGEFPDYYEDSLAVIGISC EFPGAKDHYEFWNNIKEGKESITFFSKEELRRSGISEELADHPGFVPAKSVLEGKEMFDPGFFGFSPKDAEYMDPQLRML LLHSWKAIEDAGYISKEIPETSVYMSASTNSYRSLLPEETTAQLETPDGYVSWVLAQSGTIPTMISHKLGLKGPSYFVHA NCSSSLIGLHSAFQSLQSGEAKYALVGGATLHTESSAGYVHQPGLNFSSDGHIKAFDADADGMIGGEGAGAVLLKKASDA VKDGDHIYALLRGIGVNNDGADKVGFYAPSVKGQAEVIQKVIDQTGIHPETIAYVEAHGTGTKLGDPIELSALQSVYGRY TDKKQYCGIGSVKTNLGHLDTAAGMAGCIKVVMSLYHQEIAPSINYKEPNPNLHLEDSPFFVAEEKKELTRENRAHRMAL SSFGLGGTNTHAIFEQYPDASEAADAAGPFIIPLSARKKDRLKEYAKQLLAFLERKTDTDLADLAYTFQVGREAMEERAA FITSGTAELKRQLADFINDKPAVTGCFRGEKQQAKDIAWLSDDDDSAELIEKWLAKGKGPKLCEMWSKGVAINWHKLYKD KHPKRISLPVYPFAKEPYWPKKAEKNTSAAHTGVSVLHPLVQQNTSDLAVQRFSSRFTGSEFFLKDHVVREKAVLPGAAY LEMSYEAVKRALGGLLKDQDRITLHHTIWMKPIVVHEQERQVHIALFPEEDGIISYDIYSVNADGEEVLHSQGRAEIIKA EREPEADLSAIQNRCTADILDPAAFYREGRSRGMFHGKAFQGIKSAFIGEKEVLSDIQLPDSVSHTNGQFTLHPSIIDSA IQTATICIMQEFSGQKLILPFALEYLEVIKACTPTMRAHARFSDGYQTGNSVQKADIDLFDETGALCVKVRGFSTRVLEG DAESAQPPSGSEKVLFAPVWKEAAASEKASVRADEHLIILCEDACRIKDETASGLKDAELLIAEGEGETAAERFQSYAQT IAEHIRRIISEKRQGRILIQTVISADGSQQLFAGLTGLLKTAELEYGKLDCQLIEMESIGEMPAVAQKLKNDSHQPHDKH IRYKGEKRYVKAWEEMHPAGGGIVWKDEGVYLITGGAGSLGLMVAKEIAGRVKHPKIILTGRSNLTEAKQRELAMLQHSG ANVVYKKLNAADRRENEAMIKEITAEFGKLNGIIHAAGVIQDRFLLQKTKEEFREVLDPKVIGTAYLDEASKDCNLDFFV LFSSVSGVLGNVGQADYAAGNAFMDAYAAYRQSLTENGLRHGKTVAFNWTLWKDGGMQAGDETERMMKKAFGMVPLQKAS GLAAFYEGMAQEKPQLLAAEGHAAKLKQSFLSVSETEKPQVKKIEPVSAVSGDKWHGALIRLVSSILKVGQDEIDIDTEL SEYGFDSVSFTVFTNQLNEAYQLKLAPTIFFEHGTIRSLADYLTDEAEAGLPSQPEEKHDADKSLQTLHTALTAMVSGIL KVDREDIETDTELSEYGFDSVSFTVFTNQLNEAYQLELAPTIFFEHGTISGLAGYLAKEHPGRFGEKKKESPKKEQPKAQ KPKMQRKKRFATVMNASAATQEPRRFDPVAIVGISGRFPGAKDIEEFWRNLKEGKDSITTIPKERWDWQAFDGDPNLEGN KTNIKWGGFIDGIAEFDPLFFGISPREAQYLDPQQRLLLTYAWRAIEDAGCKPESLSGTNTGVFIGTGNTGYKDLFTRAG LAPEGHAATGSMIPSIGPNRLSYLLNLHGPSEPIETACSSSLVAIHRAVSAIENGECDMAIAGGINTILTEEAHISYSKA GMLSKDGKCKTFSKDANGYVRGEGAGILMLKKLSDAERDGNPIYGVIRGTAENHGGRANTLTSPNPKLQADLLVKAYRKA GVDPSTVTYIEAHGTGTELGDPIEINGLKAAFHELAKTNQEPEVSGHRCGIGSVKSNIGHLELAAGVSGVMKVLLQMKHK TLVKSLHCETINPYIQLDDSPFYIVRENQEWTAAKDRNGNAIPRRAGVSSFGIGGVNAHIVIEEYVPKAAAQPEHSPENP AIILLSAKSKEKLFEQAQQLQKAIRQTPYTDQDLAGVAYTLQTGRDEMEERLAILAATMAELETKLEAFTKNEKNIAGLY TGQSHRNKDTFALFTADEDMDIVIDAWIKKGKFAKLAEVWVKGGVFNWNRLYEKGTPRLLSLPSYPFAKDTYWVPENPDK NKVHTEERMKRILTKQWELSPLELREPCARSVAILTGGDTINLAEEIAAHMPNHRIITASDLSGEYDWQAFDGVIDLLGA AKEDSQDMAGIKWLQQLIEHGHKEGMTLLCVTKDLESLNKEANQTTGAKRAGLYRMLAYEYGHLSSRHLDLEGALSDDKL AKQIADEFHARTDDAEVCRRDGLRYRAVLSGAENMNMKGERIDFPDNHVLLITGGTRGIGLLCARHFAEHYGVKKLVLTG RETLPPRSEWTGGLNGVPASVKAKIEAVLDLESKGVQVKVLSVPLADEAGLRQELSQIKQTLGPIGGVIHCAGVTDKETL AFIRKTDEDIQRVLEPKVDGLQALYSVLSEEPLKFFVLFSSVSAAIPALSAGQADYAMANAYMDYFANSYKEQLPIVSIQ WPNWKETGMGEVTNKAYKESGLYSITNAEGLQLLDGILLESARGPVLPAVLNPKLWKPERFLRRSRQDQPMSPAMVKPAE KTAYTAENNTQLTRKTEEWLKELFSEELRIDQDQLETDVLFQDYGVDSIILAQLLQRINRNLSASLDPSILYEYPTIQSF ANWLLEGYTEVLSERFDLAAEPVKKNPAEPVIETQAVKVQEEPAGKQIHREDIAVVGMSCRFPGAASLEAYWSLLAEGRS AIRPVPAERWGLKTPYYAGMLDGIHQFDPDFFLLAEEDVKAMDPQALAALEECLNLWYHAGYTPDEIKGEAIGVYLGGRS RHRPGEDKLLDAKNPIVALGQNYLAANLSQYFDMRGPSVVLDTACSSALVGMNMAVQALVSGEIKAAVVGGVSLFESEET HKLFEQRGILSKAQSFHVFDERADGVVLGEGVGMVLLKTVSQAIEDGDSIYAVVKAASVNNDGRTAGPATPSLEAQKSVM KTALEKSGKQPEDITHIEANGSGTVVTDLLELKAIQSVYRSKDAGPLGIGSVKPNIGHPLCAEGIASFIKVVLMLKEKSF IPFLSGEHENTHFDREKANIQFSRTLADWPSPIPAAGINCFADGGTNAHVIVEAWQEDEGRRIKRHPLTPPALNKRLISP DSKEETNEKAAANIWDTYEVEV. BaeL DH ACP KS4 DH KR ACP KS5 ACP ACP KS6 KR ACP (KS7)

MKWRFNVKNFNKQITLSLKNPFILHHDVYGQKVLPGLAYIDMFYQIFKERGYSYDGLQLRHLSIYQPLIAKEDSAVKLTV ECTKVKEGRWKLTAKGAEVSGGRVQPEERIYVKAEMHETAPAIFSETLDLDSVKREAERTIDLNELYAQCRSQELVHSGY MKAEGEVFEERDGVTFDVSLGKDAMGQAGGFLFHPTLLDGSGVGANLLISSLLNGEKRLFLPLFYESFTASEPLQAGCIT RIKRSSLRQEKELIYITLEFFNASGRKVAELKDFTSKLVRDAELINTERKTAEKSPEKAGLPEVAASLEGGHPHEEAERY VMNLMAEKIGKPLEQIDSQVGYYEMGLTSSGLLDVVETISEKIGETLSPTLLFEYTTAAELAAFLTEQYGSHFSASPAKM EKQVETQTERRRKSSVPQDEDIAIIGMAGRYPQAENIHEFWENLKEGKNCVTEIPESRWDWRRFENVKSPSGKSISKWGG FIDDPDCFDPQFFRITPREAETMDPQERLFLQTCWETIEDAGYTPKSLAEARGRNKRQRVGVFAGVMHKDYTLVGAEASS EDHVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLAAESIRRGECESAVAGGVNLSLHPNKYLTYGLWDMF STDGVCHTFGKDGDGYVPAEGIGAVLLKPLREAVKDGDRIYAVIKGSAVNHVGTVSGISVPSPVAQADLIEECLDKAGID PRTVSYIEAHGTGTSLGDPIEVQGLVKAFRQYTQDKQFCSIGSVKSNIGHAESAAGISGLSKVALQLHHKTLVPSLHSEE LNPYLDFEQSPFYVQHHTEAWQQPSVTENGNETVYPRRAGISSFGATGSNVHLILEEFIPEESHGTNAEPAEEQTFIFPV SARNEERLKEYVAKLSAFIHPGLPLEDAAYTLQIGREQMEERVVFTAQNMTQLKERLEGFLAGKTVSGCWRNRADKSKQA ELAPDLIHKWLSSGSLEMIAEKWAGGGTMDWKLLYGENKPNRISLPTYPFEKIRYWVPKAEKRESLPQKNAGMLHPLLHE NVSNMSGVRFRSSFSGGEFFLKDHVVKNERTLPGAAYLEMVRAAVEHAAETKEEGTVRLKHVVWIRPFTAADESADLYLR LYDEENGEMGFTVYSESASSEEEPVLYAQGSAAFVRAGEPAKIEIDKLRESRRLITPDACYQAYKQMGIEYGDAHKAVTE IYAKDSKVLAKLSLPSSISHTKDQFVLHPSLLDAAFHATIGLMLDRDGTDIRPMLPFALEQIDVLKSCKSDMWVSIAYSG ESKPEDAVQKLDIDVCDEQGNVCVKMTGYSAREIETDKTDTLYFEHVWEEKAAVHEEAPIHFKARHVMISDRFTDQMNSI QTDFSCHVLRDQHKSEDERFEACALQAFEEVKKILASNSGGRELIQIVVPQEADTQLLCGLTGLLKTAALENPNLTGQLI ETEPDVKADTLSRYVKECSAHPDDKHIRYENGRRYTAQWQETGLEQFGAEKPWKDKGVYLITGGAGGLGFLFAREIARHA KDAVLILTGRSLLDNRKKAQLQELSDLGAQAVYKQTDMTEKQEVQSLTADICRQYGGLNGIIHSAGTIKDNYILKKHKDE IRDVLAPKVSGLVHLDEAAKDIELDFLILFSSGAGSAGSAGQADYAMANAFMNAFSEKRNRKKARNERYGHTLSICWPLW KDGGMTVDAETEAMLTKESGMVPMQTENGIQALYRGWAANTSQVMVTEGYAAKIRAFLKKSADDQPDKGSETEEPVGLTA SGENMLAEKTEHFLKQVLSEVTKLPVGKIDAKAPMEDYGIDSIMIMHLTGRLEKSFGSLSKTLFFEYQNIESLTQYFMKA HRDTLLEVTGMKTEETPAAKPALSEKAKVKPVFKRNEGKKGFAQVRPDTRENQQLTEREDIAIIGISGRYPQAENLQEFW KNLSEGTDCITEIPNDRWDHSLYYDADKDKEGKTYGKWGGFLKDVDKFDPQFFSISPRDAKLMDPQERLFLQCVYETMED AGYTRKKLTEKSGDLLGANVGVYVGVMYEEYQLYGAEEQARGKSLALTGNPSSIANRASYVFGFNGPSMALDTMCSSSLT AIHLACQSLRNGECEAAFAGGVNVSVHPNKYLMLGQNRFLSSKGRCESFGEGGDGYVPGEGVGAVLLKPLSKAKADGDHI YGLIKGTAVNHDGKTNGYSVPNPNAQAAVIKQALKDAGTDPRAVSYIEAHGTGTSLGDPIEITGLTKAFSEQTQDKQFCA IGSAKSNIGHCESAAGIAGLTKVLLQMKHKQLAPSLHSRTLNPNIDFLATPFKVQQTLEEWKRPVINENGVNKELPRTAG LSSFGAGGVNAHIVIEEYSADEDKETAFAAPHPSMIVLSAKNEQRLQKRAKRLLDALRSGRYREADLSRIAYTLQVGREP MEERLGMIVSNLRELEEKLDEFTGGKESIDQLYRGQVKQNKDTMALFTADEDMEKTIEAWLEKGKAAKVLELWVKGLPLN WDKLYQMGRPQKISLPAYPFAKDRYWIDTSADAAVKRPAETQSAPIAPAAAPEPVIEVTTLHEETVKEKPSNITLQTLSG AKPKRTVQPASRPAVSAEKVSAVLTESLADVLYMDADDIDADDTFIDIGMDSITGLEWIKSVNKAYGTSLTVTKVYDYPT IRQFAAFLQKELGTEPILEEATEPQKTEAVKKPSNIMLQPLNAHKQHVIQAEADILEAMSETAASAEPEEPIEAVHDELS KALADVLYMERHEVDIDEAFIDLGMDSITGLEWIKAVNKRYGTDCNVTKVYDYPTIRQFADFLRAQPSVRGRKKQAVPVR PKPLTQQHAPQEKTPAEPERLTIQKEPEPVQAKREPKDEIADAIAIVGMSGKYPDAPELKTYWDNLARAKNAIRDIPLSR WDVNKYYDPALNKKGKVYCRSIGMLDDIEEFDPLFFNISPSEAELMDPQHRIFLQEGFKAFEDAGYSSKELNGKNCGVYL GIMNNEYGMMLNKHQTGGSATGNSFSIAAARLPYYLNLKGPAIPIDTACSSSLVGAHLARQALLNHEIDMALVGGVTLYL TPESYISMCEAGMLSPDGQCKAFDNSANGFVPGEGAGALVLKRLKDAEADQDHIYGVIIGSGINQDGKTNGITAPSAKSQ MDLERQVYEAHNIHPESITYAEMHGTGTKQGDPIELEALSSVFKEKTDRKQFCAIGSVKSNIGHTSAAAGVASVQKVLLS MKHQQLVPTLHFSTPNEHFDFDDSPLFVNTELKPWETGGAPRRACVSSFGYSGTNAHLVIEEYQPKDRGSRKPDETNIFV LSAKKAPQVKTYAESVIEFAKADQNINLSDMAYTLQTGRDAMDYRLAVTAGSREELISRLTDFVNGNTGEGIYEAHIKTA KKEIKAFETDDDLKQLVRSWFDKKKYAKIAELWAKGLQMDWDRLYQGEKPRRISLPAYPFAKEPYWLPEPKVIPQETEDR REAVLLEKQWVPCEIDSAGEKSGRTVMILADARTAELAEETAKHFADSFILPVDSADTAASDWNHIDGAIDLTGCGDEDP SLEGISRLQTLIDTSRRQARPLTLLYVTKGLEPFQQKTIHLAGAAKSGLYRMLQNEYQNVTSRHMDADKDTDQQTLAKQI ADEFSADCTEPEICRRNGQRYRALFREIPSGKRAEHKPAPFPEDHVLFITGGTRGLGLLCARHFTEKHGVKKVVLTGREP IPPRHKRSAVNTRLKEKIRAIEELEAKGVQVAVISLKLSDHDAAAAEIETIRRTMGPIGGVIHCAGSVNSVNPAFIRKTA EDIQEVLEPKVAGLQTLSSLFTNDPLQFFVLFSSVSAVVPALAAGQSDYAMANAYMDYFAAAHQHQYPLVSIQWPNWKET GLGEVRTESLKQTGLLGLSNAEGLDLLDRILSENIRPSVLPAIVDRSEWHPDRLLCQEKKQKETEAVINGKAAEKHSDRE LLLDTKAWLVKLFSDELKIAPEELETDEPFQDYGVDSIILAQLLQQMNQALKEDLDPSVLYEHPTIDAFAEWLVSNGQPL LAEREEPDTEMLLPAAVQTVHTEQKRDAVTEDIAVVGMSCRFPGAESLEQYWDLLRSGRSAIGSVPAERFGYANQYVAGL IDNMDHFDSEFFFIPENDAKAMDPQALAVLEESLKLWCHAGYSREEIKGIEAGVYIGGRSQHQPDPEILANTRNPIVAGG QNYLAANVSQFFDLRGPSIVLDTACSSALTGMNMAVQALRSGDIKAAVVGGVSLLNTDAAHRMFQERGLLNEKPAFHVFD KRSGGVVLGEGVGMVLLKTVSQAQKDGDTIHAVIKAAAMNNDGRTAGPSAPNMQAQKDVMQSALFKSGKKPEDISYIEAN GSGSAVTDLLELKAIQSVYRSGQHVPLGIGSIKPNIGHPLCAEGIASFIKVVLMLKHKQTVPFLSGDEPMPHFDITKTDF HFHKTAGEWDAARPSAAINCFADGGTNAHVILEAWEEKDTRMKRKPLPVPSLRRKALVKEPDAPAEKQELPAKKMFWKAF K. BaeM DH ACP KS8 DH KR MT ACP KS9 KR ACP MREEWEGMISEKINISLDHPIMKGHKVFGEAVLPGLAYIDLIYQVFQEHGYVYNELELKHVTIYQPLTVSETAAIILTIQ CSDSGDGKWLISLSGQKQQGDELSDNIQYATAEMVKRDAVTFDETIDFGDVKQSGRSLNLDDMYNRCLDHDLVHSGMMKS NGRLYETEDGMLAELSCKEGKGFFLFHPALLDASGIGASGLLSETNRLHLPLYYESFTAADRLQSECTARIAASGVRQEK ELTTMTIEYFSRSGQKVAELKNITGKAVRFEEDENTAEQNQQAATEPESADEKDIILFLKKLLADKLGQPWETLDVLAGY YELGLDSSSLLEIVQDISKKTGADLAPTLLFEYTNIKELAAYLKKTVSFECAERAAEPSRSEAEAPDTPEHHKNTGDIAI IGMAGRYPKAKSVAEFWENLKAGTDCITEVPKSRWDWKTYKNVTSPSGKTVSKWGGFIDDADCFDPQFFRISPREAETMD PQERLFLETCWETIEDAGYTPETLGNKGEKQHPIGVFAGVMHKDYSLIGAEQLSETDPFPVSLNYAQIANRVSYYCDFHG PSIAVDTVCSSSLTAVHLAIESIRRGECEAALAGGVNLSLHPAKYLSYGSVGMHSSDGRCRTFGEGGDGYVSGEGVGAVL LKPLEKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPAAQAEVIKACLKKAGISPRTVSYVEAHGTGTSLGDPIEIEGLS KAFSQGTQDQQFCSIGSVKSNIGHAESAAGISGLTKAALQLHHKTLVKSLHSAELNPYLKFEESPFYVQQQTAPWKQPSA EENGKVTHYPRRAGLSSFGASGSNAHIILEEYIQPEQKAPAPENEAAKLIPLSARNKDRLLAYAEKLARSLSEKTVLSEL AYTIQTGREAMEERAVFLVNDIRDLKQKLNDFVKGNENIPGLWRGQAELPEMSETAPETDDSIRLAELWAEGKTVDWNKL

YGSGKPRKTSVPTYPFAKERYWIPQQKKQEKSPSGTVLHPLLQENTSDFSQQRFTSLFTGDEFFLSDHVVNGQKILPGVA YLEMAAEAVKKAAAVTEKDHSVTLRQVVWVRPVMIEDKPKEIHIALYPEDNGEITYEIYSEAENGEDPVIHSQGEAVITE PGSAQIDIESVKASCNLGIVTAEECYGAFEKIGLDYGEAYRGVQQLLIGEDRLLARISLPAAVHDKKEQYTLHPSMMDAA FHASVGLLVRSIHDDADSHELALPFAMQEVEVFGPCPEHIWSYIRYTEGSKADDNVRKFDIDMCDDAGTVYVRMKGASVR ALDTSQTAGGETTEAPVGHTMLIPAWEPVALEKAGEAAADKQTAVFGGTDSRHTRIKEHLPNASYYPIRGTDDITSLTHM LEGQKELEQIIWLAPQAESADSLKEQERNVLHVFKLMKALLALGYGEKRLDWCIVTANAQPFSDQDSADPSQAAVSGLAG TMAKEYPHWHIRMIDTETDGSWPIEEALSLSAGKNGQIWAYRNQQLFERQLIPLDNMPKNGTLYQTGGVYAVIGGAGYLG EAWSEYMIRRYKARIIWIGRSTLNDSIQAKLDRLSAFGPAPEYVSADAADSASLERAYQFIKERHTKMNGIIHSAMDLSE QSLNNMKTEEFKSVLRAKADVSVSMAEVFGREPLDFALFFSSLVAFIHNVKQSHYAAGCAFSDAFAKELDQTWNCPVKVM NWGYWGNSEAAEDGDFIQLMDQIGLGLIEPDAAMEALETLMTLPVDQAAFIHTTKPVAVEGMNEREKISVYPPQPLVFSQ QPKVAPPGARLVREAEHQELDDYLYQLLIAQLKEADLLTPQSLKAYEPEHEYFKKWLNQTIAFLLEHGYLEGNADSYKLS ARAENTTAALWQKWEREKEEWLNNADTKAMTVLAETMLKALPDILREDVPATDIMFPHSSMELVEGIYKHNQVADYFNSA LSDTLTAYVKENISKHSKAEIRILEIGAGTGGTSAGIFEKLRPYQNHIKEYCYTDVSKAFLVHAETEYGKRNPYLTYKLF NAEAPLAGQDIEPGAFDIVVAANVLHATKDIRQTLRNAKAVLKDNGLLLLNEMAGNSLFPHITFGLLEGWWLHEDSALRI PGCPGLYPESWKRVLESEGWHSVFFPAEAAHELSHQIIAAKSNGIVRQKTLKAGAGKRTSPPKAAHAPELQAQTTVQKGD TSLTEKSTEYLKTLIGETLKIPPAQIDPKAPLEKYGIDSIVVVQLTNALRNVLDQVSSTLFFEYQTIEALVAHLIKTKKD AMIKLTGQTPVQEERKASPEPQAVQPAKPLRTDWRRREKRAAKETVRQISVRDVAIIGVSGRYPQAKTAAELWANIKKGK NCIEEIPRERWNWQDYYDEEKGKEGSIYTKWGGFIEDMDKFDPLFFQISPLEAERMDPQERLFLETAYASIEDAGYTPDN LCQSRKIGVFAGAMNKNYPTGYGYWSIANRVSYLFDFQGPSIAVDTACSSSLTAIHLALESIYSGSSECAIAGGVNIVTD PIHYMNLSVMNMLSAGDTCKSFGDRADGFVDGEGVGAVVLKPLDRAIADNDHIYGVIKGSTINSGGKTNGYTVPNPNAQA ALIKEAFERANVPARTVSYIEAHGTGTALGDPIEIAGLTKAFEEDTTDKQFCAIGSAKSNIGHCESAAGIAGLTKILFQL KDRQIAPSLHADQLNPNIDFAYTPFAVQQELGEWKRPVIGGKELPRRAGLSSFGAGGANAHLVIEEYTADKEPDEMPADQ PAIIVLSAKNSERLTEKAKQLRDAIREKRYSCSDLMSIAFTLQTGRVPMEERLGFIVHSLHELEEKLNGFIAGHNSAGLH RDGTEENKRMLAVFSADDDLETIIDAWISKRKYSKLLELWVKGLDIDWTKLYGDRPPARISLPAYPFAKERFWHQQPVQS KAAPVNAPADESDPAEQFEVMAFREVLKEQALPAAGDKQVKTVISFLSDQKKQQEAISMIKSYDNDIDVIFIAQGDRYEA LSAGRCQVVREDPQSYVNAFADIQKEYGEASAILYLWALEDKSCIEDYSCIVHILQAMAETGLQPERLLLAGEYASGLER CYLESWIGFERSLGIVLPKTSVTGHFRKAGAAITDWMRTIWDELKAETDQTVFLEEGKRYVYHTEPTRLTKENSRIRTGG TYLITGGLGGLGYLFARHLARNYQANVILTGRSPINEEKKEKMKDLENLGAGVLYAEADVCDPIGMGDCIKRAKERFGAI HGVIHAAGIESRTSVFENEIGNFRSTLEPKINGSLLLDEWLKNETPDFICYFSSTSAVLGDFGCCDYAVANRFQMAYANY KNEQSESGNTFVINWPVWKNGGMDVGGEETTGMYLKSSGQRLLETDEGIELFERIISQDNTQCLVIAGERSRAERFLGIR RDDSSKPDALLETVSRRIPEESTEKRLEADLKELIHSLLKISKDKLVLHKNWAEFGFDSIYLAKFAALLTSHYGIEVTPA LFYSYATLGDVISYYLTEHKETIETFYRTEETETEAAAPESKEYTDQEIIAMMKQVSEGTLDFKRVQDIIEGSKTYES. BaeN C A PCP KS10 DH KR ACP KS11 DH KR ACP KS12 DH KR MNHKELLDAYRSGTLTIAEVEQKLQAFKRTTAKRPLSEGQKGLWMLQKMFPEMSAYNIPLCFRFQKLDIETFKNALLSVQ RQHPILTSVIKEENGLPYQIEDTDRHFPIEEMDLSELSGRDALSFIKEKAKEPFALETGPLLRVQVFRRAKREPIVLITI HHIIFDGVSLMTFMSALLDAYAKASEGKEPVMLQQAADYHDFVKWEKELLESAAGKTHLSYWKKQLEGPLPVLELPSDYP RSSVQTCRGQAYQRLLPDELNRQIKVCAQKHNVNESVVYLAIFKGLLYQYTNQEDVIVGMPTMGRSEAQFESVIGYFINM IAVRSRETGAKSFTSFLKELQLTLAEGLDHAAYPFPALVKELKTERSPAVSPVFQTAFFYQNFFRTEGAEKLAELYQSLG IEMIEDIHQEGEFELALEVYKKETGTVLQFLYNPDVYSPSFIERMAEHYMKLAEKVLSDPEIAFEACSGLLNQKRDESRS SHQPNERCIHEVFVEKAGRHPDREAVTFGENSLTYRELDERSTALAVYLQEKGVTPECPVGICTERSFEMVIGILAILKA GGAYVPLDPAFPNERMAHVLTDSGVSIVLTQEKTRGMIEQLAIGGVSTVEIENSGRSVSGAKLTPRSKPHHLAYILYTSG STGKPKGVMVEHRAIMNTLQFLEAEYPVAQEDAYLLKTNYVFDVSISELFGWFIGNGRLVILPPGAEKNPQLCMEYIQTH QVTHLNFAPAVFNVFLETVKRHTAFTEDGPVKYVMVAGEAFPKDLVKKSVSIFKHARIENIYGPTETSIYAAYYSCGQKE ITSRNTPIGKPIHNTRLYIVDEKLSPVPDGVAGELCVAGAGLARGYYNQPELTAASFIDNPFSEGEKLYKTGDLARWLPD GNIEYAGRIDSQVKIRGFRIELGAIETKLSEHPDILDQAVVVQEKNGHKKLIAYYTARSGHTADEKALRNHLLSSLPDYM APAHFIRLDALPLTPSGKVNRKDLKQRKVIVHRSEKTGRLPLSEAEAKVTAIWEDLLNTAGIKIEDGFFDVGGDSLLAVA AAERIKQELECDFTVTDLFEHSTIQAISRFIVETKQAAESEASCQDEREREQTPQNGVPSYFDDSVAIVGISCQFPGAKN HHEFWKQLREGKESVRFYSEEELREAGVPEDLIENPDYVPALSTIEGKDLFDPEFFHISPKDAEFMDPQLRLLLLHSWKA VEDAGYVSKEIPKTSVYMSASNNSYRSLLPEKTTEGHESPDGYVSWVLAQSGTIPTMVSHKLGLKGPSYFVHSNCSSSLV GLYSAYKSITSGESEYALVGGATLHAATSIGYVHQNGLNFSSDGHVKAFDASADGMAGGEGAAVILLKKASQAVQDGDHI YAMLRGIGLNNDGADKVGFYAPSVKGQTDVIQHVLDSTNIHPETISYIEAHGTGTTLGDPIEMSALQQVYKRYTDREQYC GIGSVKTNIGHLDTAAGLAGCIKVAMSLYHRELAPTINYTSPNPNIKFSGSPFYVADKRKTLPERETPHRAALSSFGLGG TNAHAIFEQYENKTISGSNDGQPPYIVPLSARNKQRLTAYASCLSGFLDEAENDVSLHDLAYTYQTGREAMEERAVFISH DRHDLNRQLQDFINGNDQNILRGEKVRSREVSAQEMEELAACQTRDEKLKALAALWVEGARVDWGLLYPDSAPQRISAPT YPFAEERFWPEETVKQTDTKLLHPLVHQNTSVLQEQRFSSEFTGKEYFIAEHIIKGMAIVPAAVTLEMARAAAEKSIGGA TEESLGLRLKNIVWVRPVIADQEAVRVHIGLYEEEDGQIQYRMYGGNDSIGEEAPLYNQGIAEIIRKEPEEAADIEQLKR RCTQGTIESQAFYKGMIGADYGPGYKGVQLVYKGEDRLLAKLKLPESVSHTKADYILHPSMMDGALQAAEYLQNVTRALL AESGEPFKAALPFALEELDVLNPCADDMWVHVTFSANNKAGDPIQKADIDLYDNNGGLCVRMRGFSTRIMEENAGAGVSV SRTDTLLAEPVWKEQPEPADHEPSYEEHIIFLCEYDEAVKQAVEAKLEHASVIILDARPASIAERYHSYAGQLFDHIKTI MKSKPKGRVLFQAVTRSAGLQRVFSGITGLFKTACLEHSKLICQMIEAEEEESAEGIAEKASENRMHAESVHVKYENGKR FAADWEDMDISQAEPDIPWKDEGVYLITGGAGGLGLIFAKEIANCTKDAVIILTGRSALREKQKDMLETVRAADASVFYE QTDVTDEAEVYRLIRNIRKRHGRLDGIVHSAGIIKDNYMVKKTAEEYQHVLAPKVKGLVYLDEASQHEKLDVFIVFSSLS GVLGSVGQADYASANVFMEMYAEYRRSLQAAGQRYGKTLSVSWPLWKEGGMQAGKQTEDMLMQEAGIAPLGTDAGIKALY QGLMSGTARMTVLEGDVKHMKAKLFRKENDRPEVETGVRHDIDADSLLEKVKHLLKQQTASLLKVNIDKIDPHEEMTKYG LDSISMTEFTNQLNKTYRLTLTPTIFFDHPTIHEFAVHLISEYEEEFAGRFAVNTKTVQSARPVKETQITRPAVKRRRTL PETLPQTVQRGQGPEPIAIVGISGIFPMAEDIEAYWQNLKEGKDCMTEIPKDRWDWRDYYGDPAKEANKTNVNQGGFIDG IAEFDPLFFGISPREAEQMDPQQRLLLTYAWKAIEDAGYASKSLSGTKTGVFIGTGNTGYGSLLANADAEIEGSSAANTS PSVGPNRVSYTLNLHGPSEPIDTACSSSLVAIHHAVSSIEEGTCDMALAGGINTIVLPDVYISFDKAGALSKEGRCKTFS DQADGFAHGEGAGLFFLKKLKAAEADGDHIYGVIKGSAVNHGGRAASLTTPNPKQQAEVIKAAYKKAGIDPKTVSYIEAH GTGTELGDPVEINGLKQAFSSFADGKEKAAGYCGLGSVKTNIGHLSLAAGAAGIIKILLQMKHRTLVKSLHCETVNPYIQ

LEDSPFYLVRETMEWKTRTDERGNEQPRRAGISSFGIGGVNAHVVIEEYIPEDREEADDSHIDPCLFVLSAKNEKRLKEQ AKQLKRALTEKRYDQSSLVSMAYTLQIGRDAMEERLAVIAGSAEELQEKLSQFITGDKHADLYRGRIDKGTLQMLTEDEE IQEAVEKWMARGKYAKLLELWVKGLNVDWAKLYGDRPPKRMSLPSYPFAKDRYWAAKSTGKHEKTSTVSAGKQDALHPLL HRNTSNLAEQRFSSIYTGKEFYLADHVVKGVPILPGVAHLEMARAAMEQASEVPAGQGSVKLKNTVWVRPITIEDEPVHV NIRLIPETANDVQFDIYSGRETDQPSVYSQGAVSVRPDAEAPVIDLQKLRSQSAETPFSADEVYDMYRKIGFDYGPAFRG VKAIYTGDDFVLGRLSLDAACAGTVQEYVMHPGLMDSALQASSILTGTNDEKLMLPFAVQELEVFSACVAEMWVYARLSE DHKAGQIEKRDLDICDENGKVCVRLKGLSFRMAEKEPEKKEKAPGTLMLEPVWTRSDETATQTEPVFARHIVLLCDTDGG LKQAVEAAGAECIEMTSQHGKAAARFRDYTGRILETLQKLLKEETDGDVLIQTVLSKTDKHQLLSGISALLKTAGLEHKK LKTQLIEIEPAENGRITDIIRENKTRADDSHIKYENGIRYSADVKETAVSGGKIRIPWNDGGIYLITGGAGGLGFIFAKE IARKVKEPTLVLTGRSALSENQRMQLQSLESLGAKAEYKQADVTNAQTAADLVKTIETEYGGLHGIIHSAGVMKDQYIAK KTTEEFYSVLAPKTDGFVNLDEATEHLALDFFIVFSSISGVTGNAGQADYAAANAFMDGYAAYRNALVTAMYRHGHTLSV NWPLWKNGGMQVNEEMAKLTEKRTGVTPMRTETGIEALYKAWSTGKTSVLVMEGNRAVMREKLLQKTPASAFAPVKKTGE MPAPKDLTAKLQELLAKEVSGLLKINIEEIDIELEFNQYGFDSITLTEFANKLNDTYQLDLTPTVFFEYATIQALAHHLA EDYQTQFAGSTQPKEEKQSGVTDDGGIRLAGNKRFAKTAVQPVQTAAEHKPEPIAIVGMSGVFPKAANIDEYWRNLEEGK DCITEVPADRWDWREYYGDPLNEANKTNVKWGGFIDGVADFDPLFFGISPLEAEQMDPQQRLLMMYAWKAIEDAGYSAKS LSGTKTGLYIGTGNTGYGSLFSDLDIGGASAANMSPSAGPNRVSYMLNLHGPSEPIDTACSSSLVAIHHAVCAIENGNCD MAIAGGVNTVVTPQGHIAYDKAGALSKEGKCKTFSDRADGFAVSEGAGILFLKKLSEAEKAGDHIYGVIKGSAVNHGGRA NSLTTPNPKAQAEVVRTAYDKAGIDPRTVTYIEAHGTGTELGDPVEINGLKSAFQKLYEKTGDPAVYASHCGLGSAKTNI GHLSLAAGVAGVIKVLMQMKHKTLAKSLHSEVINPYIKLKDSPFYIVQEKREWTALKDENGNHLPRRAGISSFGIGGVNA HVVIEEYIPKEERKTAVFTHPQIFVLSAKEEERLQEQAQQLAQASFTDADLTDVAYTLQQGRDAMEERAAIIASSAEELR DKLKSCAKGRYDIAGIYKGKAGKTSLKSILAGANGEADIEELISRRENDKLAELWVQGADIKWDGLYSDIKPQRLSLPAY PFAKERYWITDNRPKAEKPQAVPTSRVLHPLLHENVSDLTEQRYRSEFTGQETIFTDHLIKGKPVMPGVAYLEMARAAVA QAVKGQKERPSVTRLKNIVWVRPIEAGNRPIEAQISLNPRENGEIVYDVYTNSQTEASGRQIHCQGAAGILSAGEAPHRD IGALKAQCGLSILTSEQCYGLFSKIGIDYGPGQQGIQQIHIGSNQALAELRLPSFLEETADQYVLHPCMLDSALQATIGL KLHADDNQLSLPFALEELDIFSPCTTSMWAYVSSRGTDEKIQRMDIDLCDETGRVCVRIKGISSRMMEGPAPETSLNGAN LLAPVWDLAEFRDQSPAYKTEEVVFIAGDEESAAFQLHHPSAKRLHITPEDEIEAVAAELKATGSFGHIVWIAPFHSADD MVKAQDAGVIQMYRVIKAMLALGYGGKRISLTAVTIKTQSVQPADIIDPAHAGIHGLVGSLAKEYPNWQTRLIDAGCPED VSKAELFSAPFDEQGNTWAYRNNHWYKQRLIPVQQPVSSRPAYQKGGVYVVIGGAGGIGEAWSEYAVKTYQARVVWIGRR KHNSAIQEKIDRLSQFGPAPIYIEADAANPNELTRAYETIKRTHPQINGIIHSAIVLEDQSLANMPESRLKSVLAAKVNV SVNMARVFRNEPLDFALFFSSVQSFARAAGQSNYAAGCSFKDAFAAHLAQVRPYSAAVMNWSYWGSVGIVSSADYQERMK QAGVGSIEAPEAMAALERLLGGPLNQFVMMKQAEEPEEKPEEMIEVYPEHHGSAMQKLRSYQPKVTRHVQQLS. BaeR MT ACP (KS13) DH ACP KS14 ACP TE VKEGTALQNTEDLLYKLLAGQLKSVGFFTENETQPVMQGFYGRWLEESISILVQKGFLKQSGSTYVLTDPIERADVLWQE WDEKKAPLLKDSSKQAMITLVETALRALPDILSGRVSATDVLFPDSSMELVEGIYKNNETADYFNEVLADTLTAFIEERL KEDPNAEIRILEIGAGTGGTSAAVFKRLKEYKHHVKEYCYTDLSKAFFMHAEKKYGPDNPYLTYKRFNVEEPPALQGIEA GAYDAVIAANVLHATKNIRRTLRNAKAVLKKNGILLLNEISSHSVYSHLTFGLLEGWWLYEDAKLRIPGCPGLYPEAWQS ALESEGYRYVTFMAESSHHLGQQIVAAESDGVIRQKQPDAQAVEETAASKEPADFTEPSFSVTDRTVQFIKETLAKSIKL APERIQPETSFEKYGIDSILQVNFIRELETLTGELPKTVLFEHTNTKELAEYLLENYPDKLQQAFGAEQVPPETEHPEPA MNEPVPLVTETRRFITEPKAPKPETETVTVNRSDRDDIAIIGISGRYPESETLDELWEHLKAGDSCITEAPENRWKSGLL KTMAKETRKEERKTRYGGFLQHIDAFDHHLFDIREDHVMEMTPELRLSLETVWETFENGGYSLERVTEWQESDSGIGVFM GSMYNQYFWNIPSLEKAALSSNGGDWHIANRISHFFNLTGPSMGVTTACSSSLSAIHLACESLKLNSCSMAIAGGVNLTL EPSKYDALERANLLEQGSESKSFGTGTGLMPGEGVGAVLLKPLSKALADKDHIYGVIKSSALCHSGGRQMYTAPDPKQQA KLMAASIDKAGINPETISYVESAANGSVLGDPIEVIALTNAFAQYTDKKRFCALGSVKSNLGHLEAASGMSQLAKVLLQM ERETLVPTINAKPQNPNINLEQTAFYLQEKTEYWERMRDAETGDIIPRRSMINSFGAGGAYANLIVEEYISPNSDQARHG DEEYIFPVSAKTKWSFEAYLDRLTAFLEKTPPLHPAAIASALQKRTHHSKYRAAFTAASVQELLEKLAAYRMDQRNLNFS ESDIGRRARQWEKGENIAFDQLQQEHAVHLPAYAFDHGTSFQFGESENAAGVQAVYSDDDPYVKGHQFSGEPVLVGATYN SLAVDHFCDLFPEAEGGQIKKLNYASPITVKKGDRIELKTESKQNGDGFELSIMHRSRTSPDWSIAAYAECSPYPFQKQH ADLAAIQRSYREVGRIDELYGDGTGTVVWGEEFKTITRLYKGSDAVLAKVNLNNSDSQQAHHYAVNPLIANSAYLASLSL LDQTEAESYLPFGINSVTFSSPEDLTDCWLHIKLAKQTGEMILINADVISRRSEVVMRFEGYALKRFRPKTEQMNQPART AVKNAGAPISAGSLTDDIRSYVLGKLAKTMDEPAPSLRSDANIMELGLDSVSLIGLTKEIGQEADIDVNPTLFFEYPTAE ELTRHFASAYESKFSQLLADHKHSEEARVTETEERTLPRKQHPPCDNADVKQGIAIIGMSAQFPQSPDIQSFWEHIVNGD HCITEIPADRWDWRRYAGDENDTSLRWGGFIDGVGEFDPLFFGISPKEASQMGPEQFLLLMHTWKAMEDAGLTNKALSSR PTGVFVAAGNSDPNNGTAIPSIIPNRISYALNLQGPSEYYEAACTSTLVALHRAVQSIRHNECEQAVVGAANILQSPKGF IGFDSMGYLSKNGRAKSFQKDADGFVRSEGAGVIIIKPLEAAIEDGDHIHMVIKGTGVSHGGKGMSLHAPNPAGMKAAMK KAYEDTDVDPQTVTYIEAHGIASEMADALEFNAIKAGYGESANQEESAPCYISTVKPCIGHGELASGLAALIKVAMAMKH HTIPGIPRFTAANEQMAIQKSRFRFTEDNQEWTQLTDHTGRPIPRRAAINSYGFGGMNAHVVLEQYSSSHKDKESVHEPQ LIVLSAKSEGRLKAAAGQLADFVQTGDTPSLRDIAYTLQTGREAMNGRLALVARNQDELLEKLKEYRAFSEESNGMKSFF TGSQQTGSGDIGILLEGTLGTVVTETLLAENNLEKLAFCWVKGADIPWDRLHQGKSVKRVPLPTYPFENHKYWKGGQPED ISLAPVSQDPQLCRESAADIVADILGMKAAEIDQNKPLTEYGFDSISSIQLLKKLEDGDSRISLEALQKCSTLQEIGMLL KTNQPQETGRNFPELVKLNEREKGRPVFWFHGGTGGVEAYQPFAKKSQRPFYGIQARGLTGKEPLQGIEETAASYKRIIQ AVQPKGPYDLGGYSLGGMLAYETARLLQEEGHTVKSAVMIDTPYSEKWKERKPSVKSVMLQTINTMLTAYLKPENLEEAL ISREDITVQAEEEEVLKELIGLAKKRGLPKSEEAIRMQLEQMMKTQLAYGMEEYDMKPLPHPEALQCYYFRNKSGLFLGD LERYLTAEEEQIPLDHDAYWKEWEHQMKQFHLLDVHSSNHVTMLSEPKPQNAIKAFCEKLYANKGTISANFLKSFRKKLD ETNELVKR. Bacillaene (B. subtilis) PksK AL ACP C A PCP KS1 DH KR ACP ACP KS2 KR ACP (KS3) MRNNDNIRILTNPSVSHGEPLHISEKQPATIPEVLYRTATELGDTKGIIYLQPDGTEVYQSYRRLWDDGL

RIAKGLRQSGLKAKQSWILQLGDNSQLLPAFWGCVLTGVVPAPLAVPPTYAESSSGTQKLKDAWTLLDKP AVITDRGMHQEMLDWAKEQGLEGFRAIIVEDLLSAEADTDWHQSSPEDLALLLLTSGSTGTPKAVMLNHR NIMSMVKGIIQMQGFTREDITFNWMPFDHVGGIGMLHLRDVYLGCQEINVSSETILMEPLKWLDWIDHYR ASVTWAPNFAFGLVTDFAEEIKDKKWDLSSMRYMLNGGEAMVAKVGRRILELLEPHGLPADAIRPAWGMS ETSSGVIFSHEFTRAGTSDDDHFVEIGSPIPGFSMRIVNDHNELVEEGEIGRFQVSGLSVTSGYYQRPDL NESVFTEDGWFETGDLGFLRNGRLTITGRTKDAIIINGINYYSHAIESAVEELPEIETSYTAACAVRLGQ NSTDQLAIFFVTSAKLNDEQMSQLLRNIQSHVSQVIGVTPEYLLPVQKEEIPKTAIGKIQRTQLKTSFEN GEFDHLLHKPNRMNDAVQDEGIQQADQVKRVREEIQKHLLTCLTEELHVSHDWVEPNANANIQSLGVNSI KMMKLIRSIEKNYHIKLTAREIHQYPTIERLASYLSEHEDLSSLSADKKGTDTYKTEPERSQATFQPLSE VQKGLWTLQKMSPEKSAYHVPLCFKFSSGLHHETFQQAFGLVLNQHPILKHVIQEKDGVPFLKNEPALSI EIKTENISSLKESDIPAFLRKKVKEPYVKENSPLVRVMSFSRSEQEHFLLVVIHHLIFDGVSSVTFIRSL FDTYQLLLKGQQPEKAVSPAIYHDFAAWEKNMLAGKDGVKHRTYWQKQLSGTLPNLQLPNVSASSVDSQF REDTYTRRLSSGFMNQVRTFAKEHSVNVTTVFLSCYMMLLGRYTGQKEQIVGMPAMVRPEERFDDAIGHF LNMLPIRSELNPADTFSSFISKLQLTILDGLDHAAYPFPKMVRDLNIPRSQAGSPVFQTAFFYQNFLQSG SYQSLLSRYADFFSVDFVEYIHQEGEYELVFELWETEEKMELNIKYNTGLFDAASISAMFDHFVYVTEQA MLNPSQPLKEYSLLPEAEKQMILKTWNATGKTYPYITFHELFEQQAKKTPDRAAVSYEGQTLTYRELDEK STQLAIYLQAHGVGPDRLAGIYVDRSLDMLVGLLAILKAGGAYVPLDPSYPAERLEYMLEDSEVFITLTT SELVNTLSWNGVTTALLDQDWDEIAQTASDRKVLTRTVTPENLAYVIYTSGSTGKPKGVMIPHKALTNFL VSMGETPGLTAEDKMLAVTTYCFDIAALELFLPLIKGAHCYICQTEHTKDVEKLKRDIRAIKPTVMQATP ATWKMLFYSGWENEESVKILCGGEALPETLKRYFLDTGSEAWNMFGPTETTIWSAVQRINVECSHATIGR PIANTQIYITDSQLAPVPAGVPGELCIAGDGVAKGYYKKEELTDSRFIDNPFEPGSKLYRTGDMARWLTG GRIEYIGRIDNQVKIRGFRIELGDIESRLSEHPGILECVVVADMDNLAAYYTAKHANASLTARELRHFVK NALPAYMVPSYFIQLDHMPLTPNGKIDRNSLKNIDLSGEQLKQRQTSPKNIQDTVFTIWQEVLKTSDIEW DDGFFDVGGDSLLAVTVADRIKHELSCEFSVTDLFEYSTIKNISQYITEQRMGDASDHIPTDPAAHIEDQ STEMSDLPDYYDDSVAIIGISCEFPGAKNHDEFWENLRDGKESIAFFNKEELQRFGISKEIAENADYVPA KASIDGKDRFDPSFFQISPKDAEFMDPQLRMLLTHSWKAIEDAGYAARQIPQTSVFMSASNNSYRALLPS DTTESLETPDGYVSWVLAQSGTIPTMISHKLGLRGPSYFVHANCSSSLIGLHSAYKSLLSGESDYALVGG ATLHTESNIGYVHQPGLNFSSDGHIKAFDASADGMIGGEGVAVVLLKKAADAVKDGDHIYALLRGIGVNN DGADKVGFYAPSVKGQADVVQQVMNQTKVQPESICYVEAHGTGTKLGDPIELAALTNVYRQYTNKTQFCG IGSVKTNIGHLDTAAGLAGCIKVVMSLYHQELAPSVNYKEPNPNTDLASSPFYVVDQKKTLSREIKTHRA ALSSFGLGGTNTHAIFEQFKRDSDKGKIDGTCIVPISAKNKERLQEYAEDILAYLERRGFENSQLPDFAY TLQVGREAMEHRVVFIADHVNELKQRLTDFINGNTAIEGCFQGSKHNAREVSWLTEDEDSAELIRKWMAK GKVNKLAEMWSKGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQISGNQTGIGSIHPLLH QNTSDFSEQKFSSVFTGDEFFLRDHVVRGKPVLPGVAYLEMAYAAINQAAGSEIGQDVRIRLNHTVWVQP VVVDRHSAQVDISLFPEEDGKITFDIYSTQEDGDDPVIHSQGSAELASAAETPVADLTEMSRRCGKGKMS PDQFYEEGRSRGMFHGPAFQGIKNVNIGNREVLAQLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQE LTDQKLILPFALEELEVIKGCSSSMWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGFSTRVLEGE VHTSKPSTRHERLMLEPVWEKQNEEREDEDLSYTEHIIVLFETERSVTDSIASHMKDARVITLNEAVGHI AERYQCYMQNIFELLQSKVRKLSAGRIIIQAIVPLEKEKQLFAGVSGLFKTAEIEFSKLTAQVIEIEKPE EMIDLHLKLKDDSRRPFDKQIRYEAGYRFVKGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKE IANRTGRSTIVLTGRSVLSEDKENELEALRSIGAEVVYREADVSDQHAVRHLLEEIKERYGTLNGIIHGA GSSKDRFIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCLGNAGQADYAAANSFMDAF AEYRRSLAASKKRFGSTISFNWPLWEEGGMQVGAEDEKRMLKTTGMVPMPTDSGLKAFYQGIVSDKPQVF VMEGQLQKMKQKLLSAGSKAKRNDQRKADQDQGQTRKLEAALIQMVGAILKVNTDDIDVNTELSEYGFDS VTFTVFTNKINEKFQLELTPTIFFEYGSVQSLAEYVVAAYQGEWNQDATAKGKDERTNLVHSLSSLEASL SNMVSAILKVNSEDIDVNTELSEYGFDSVTFTVFTNKINEEFQLELTPTIFFEYGSLHSLAEYLTVEHGD TLVQEREKPEGQEELQTKSSEAPKITSRRKRRFTQPIIAKAERNKKQAADFEPVAIVGISGRFPGAMDID EFWKNLEEGKDSITEVPKDRWDWREHYGNPDTDVNKTDIKWGGFIDGVAEFDPLFFGISPREADYVDPQQ RLLMTYVWKALEDAGCSPQSLSGTGTGIFIGTGNTGYKDLFHRANLPIEGHAATGHMIPSVGPNRMSYFL NIHGPSEPVETACSSSLVAIHRAVTAMQNGDCEMAIAGGVNTILTEEAHISYSKAGMLSTDGRCKTFSAD ANGYVRGEGVGMVMLKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADLLVRAYRQADIDPS TVTYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCGIGSVKSNIGHLELAAGISGLIKV LLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQEWKSVTDRDGNELPRRAGISSFGIGGVNAHIVIE EYMPKANSEHTATEQPNVIVLSAKNKSRLIDRASQLLEVIRNKKYTDQDLHRIAYTLQVGREEMDERLAC VAGTMQELEEKLQAFVDGKEETDEFFRGQSHRNKETQTIFTADEDMALALDAWIRKRKYAKLADLWVKGV SIQWNTLYGETKPRLISLPSYPFAKDHYWVPAKEHSERDKKELVNAIEDRAACFLTKQWSLSPIGSAVPG TRTVAILCCQETADLAAEVSSYFPNHLLIDVSRIENDQSDIDWKEFDGLVDVIGCGWDDEGRLDWIEWVQ RLVEFGHKEGLRLLCVTKGLESFQNTSVRMAGASRAGLYRMLQCEYSHLISRHMDAEEVTDHRRLAKLIA DEFYSDSYDAEVCYRDGLRYQAFLKAHPETGKATEQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVK KLVLTGREQLPPREEWARFKTSNTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPI GGVIHCAGLTDMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSAGQAD YAMANSYMDYFAEAHQKHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSEGLRFLDQIVSKKFGPV VLPAMANQTNWEPELLMKRRKPHEGGLQEAALQSPPARDIEEADEVSKCDGLLSETQSWLIDLFTEELRI DREDFEIDGLFQDYGVDSIILAQVLQRINRKLEAALDPSILYEYPTIQRFADWLIGSYSERLSALFGGRI

SDASAPLENKIEAEASVPGKDRALTPQIQAPAILSPDSHAEGIAVVGLSCRFPGAETLESYWSLLSEGRS SIGPIPAERWGCKTPYYAGVIDGVSYFDPDFFLLHEEDVRAMDPQALLVLEECLKLLYHAGYTPEEIKGK PVGVYIGGRSQHKPDEDSLDHAKNPIVTVGQNYLAANLSQFFDVRGPSVVVDTACSSALVGMNMAIQALR GGDIQSAIVGGVSLLSSDASHRLFDRRGILSKHSSFHVFDERADGVVLGEGVGMVMLKTVKQALEDGDII YAVVKAASVNNDGRTAGPATPNLEAQKEVMKDALFKSGKKPEDISYLEANGSGSIVTDLLELKAIQSVYR SGHSSPLSLGSIKPNIGHPLCAEGIASFIKVVLMLKERRFVPFLSGEKEMAHFDQQKANITFSRALEKWT DSQPTAAINCFAGGGTNAHVIVEAWEKDEKHAIKRSPISPPQLKKRMLSPGEPKLEAETSKMTAANIWDT YEVEV PksL DH ACP KS4 DH KR ACP KS5 ACP ACP KS6 KR ACP (KS7) MRWRSNVKKITKQLTLSLKNPFIYHHVVYGQNVLPGLAYIDIIYQIFREHGFSCSELQLRNLSIYQPLTA EQDAVIVLNIQCAEKKEGQWQITAKGIEKRDGKEASEEKLYMKADMHADSPAIFEETLDLSQIKASAQNV VQLDDVYEQCRRQELVHSEYMKAKGCIYEEEDGVLLELSLGSEAMLHAEGFMFHPTLIDGSGVGANHLLT SLLKGEQRLYLPLFYESFSASALLQTDCMTRIKRSSVRREKELIYVTLEFFNASGEKVAELKNFTSKLVR EAELISGKHQDAQETQMTRADTAERDKPADMVSSPVNSYSEAEQFVSQLIAEKINKPVEQVEKQVGYYQM GLNSSGLLEVVETISDKIGESLSPTLLFEHTTIAELSAFLAEEYAEHFSAAGSLGQNERARVSDSINDHK TVEGSRPAPIEAAGDIAIIGLAGRYPKAANIHEFWNNLKEGKDCVSEIPESRWDWQRLEGITSPSGKDIS KWGGFIDDPDCFDPQFFRITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNKRQHVGVFAGV MHKDYTLVGAEEASAENVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLALESIRHGECDV ALAGGVNLSLHPNKYMTYGVWDMFSTDGHCRTFGKDGDGYVPAEGIGAVLLKPLRQAEEDGDRIYAVIKG SAVNHVGTVSGISVPSPVSQADLIETCLEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLVKAFRQYTQDR QFCSIGSVKSNIGHAESAAGISGLSKVALQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQPVI KENGEDVPYPRRAGISSFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSARNQERLRVYAKRL LDFLHDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAFIEGRKAIQHCWKGRVSRGSEPSRPA ESVHKLLEQRKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVRYWVPKAEKKTDRSKQERHIL HPLLHQNVSDISGVRFRSAFTGREFFLKDHVIKGEHVLPGAALLEMVRAAVERAAADQFPTGFRLRNIVW VRPFAVTEQQKDIDVRLYPEENGEITFEICRDPESAEESPIVYGQGSAVLCEAGENPVINIEELKASYNG RTLSPFDCYEAYTEMGIHYGDSHRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGL RLGGATSLEDRKAMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEGQVCVRLTSYS ARVLETDQEGPSEANDTLLFEHIWEERAAERQELIEYDTYKVVVCDVGEQMESLQNHLDCTVLQHDTETI DERFEGYAIQLFEEIKQLMHSKTGGHTFIQVAVPALDEPQLLSGLTGLLKTAELENPKLTGQLIEIETGM SAGELFEILEENRRYPRDTHIRHWQGKRFVSKWKEVSGEHLSADMPWKDKGVYLITGGAGGLGFIFATEI ANQTNDAVVILTGRSPLDERKKKKLKALQKLGIQAIYRQADLADKQTVDALLKETQNVYGDLDGIIHSAG LIKDNFIMKKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQADYAMANAFMNAFS EYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMVAMETDRGIQALYHGWTSGKPQVLV ASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEAEKADMIGEIDEEILREKAENYFKQVLSSVIKLPAGQ IDAEAPLEDYGIDSIMIMHVTGQLEKVFGSLSKTLFFEYQDIRSLTRYFIDSRREKLLDILGFETGKPSV ERKSEPEKQEIPVIPRKSGFLPLQDKEQKQVREKETEEIAIIGISGRYPQADNIDELWEKLRDGRDCITE IPADRWDHSLYYDEDKDKPGKTYSKWGGFMKDVDKFDPQFFHISPREAKLMDPQERLFLQCVYETMEDAG YTREHLGRKRDAELGGSVGVYVGVMYEEYQLYGAQEQVRGRSLALTGNPSSIANRVSYYFDFHGPSIALD TMCSSSLTAIHLACQSLQRGECEAAFAGGVNVSIHPNKYLMLGQNKFMSSKGRCESFGQGGDGYVPGEGV GAVLLKPLSKAVEDGDHIYGIIKGTAINHGGKTNGYSVPNPNAQADVIKKAFVEAKVDPRTVSYIEAHGT GTSLGDPIEITGLSKVFTQETDDKQFCAIGSAKSNIGHCESAAGIAGVTKVLLQMKYRHVAPSLHSNVLN PNIDFLNSPFKVQQELEEWKRPIISVNGKDIELPRIAGVSSFGAGGVNAHILIEEYAPEPVEERLPARKQ PAVIVLSAKNEERLQKRPERLLHAIREQTYVEADLHRIAYTLQVGREAMKERLAFVAETMQELEEKLYEC ISGTENREYVYRGQVKSNKEAIAAFAADEDMSKTIEAWLQKGKYAKVLDLWVRGLRIDWSTLYQDQKPRR ISLPAYPFARDRYWIDVNAKAEEKRTEEPFAPVQPVIPKPSVDREASGKPANITLQPLMTNQDRLERVPS DTETETITAEALCDELTAGLAEVLYMDQNEIDPDEAFIDIGMDSITGLEWIKAINKQYGTSLNVTKVYDY PTTRDFAVYLAHELSTQAGEKKQTETYTPIRQKTVVPAAKPANISLQPLEHHQPVQEEAEETIQYAAAEI SASRQYTVAIETLHENLRESIADVLYMEPYEVDIDEAFIDIGMDSITGLEWIKAVNKQYGTSFTVTRVYD YPTIRDFAEMLKSELGTHLDRKIEHTDSFEAAQQKPAASSHPKPAERPLQPVQHPIKKEHEKKTVPVLQD RPEDAIAIVGMSGRYPGARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMGMLDDI EHFDPLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLGIMSNEYGVMLNRQSRAN ATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLARQALINKEIDMALVGGVSLYLTPESYMSMC EAGMLSPDGQCKAFDNGANGFVPGEGAGALVLKRLKDAEADRDHIYGIIIGSGINQDGKTNGITAPSAKS QMDLERDIYETYGIHPESISYVEMHGTGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAA GVAGVQKVLLCMNHKTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHI VIEEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQTGREAMDYRM AFLADSREMLIKALDDYLAEMPNASIFAAHVKTKKSEIKLFETDHDAKALLQTWIEKKRLEKVAELWVKG LQIDWNKLYGEYTPRRISLPAYPFAEEYYWLPTQEGEPETIATAMPQFELMPKRCFLRKQWQPCPIEPAE MTNQTVAILANEETMALAEELSAYFSTYRIFDSQELDRVSAADYEHVAGAIDLIGCGTSHEHSMGWINWL QKLIEQGRASKHHLTVLGVTKGLEAYANEGVLLSGASRAGLYRMLQSEYSHLTSRHADMECEASHEELAR LIAVEYYAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGLGLLCARHFVKTY GVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQVLSLDLTDRVAVEQSLKTIHETMGA

IGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKVEGLQTLFDLLQDEPLAFFTLFSSVSAAIPALAAGQA DYAMANAFMDYFAEAHQDKCPIVSIQWPNWKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYA VVLPAVPDTNVWKPDKLMQPSLPVEALSHPETKEQTSTRNLFPETVDWLVTLFSDELKIAAEDFETDEPF QEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISRVLQPSVPEKQTPLKPQSAM KQKLVPEQRPQQISHEKTALLAEDIAIIGLSCRFPGAETLEEYWDLIRDGRSAIAPVPPERFGNSSSNYA GLIDEMNRFDHDFFMMSESDVRAMDPQALAVLEESLKLWYHAGYTEKEVKGMRAGVYIGGRSQHKPDPAS LSKAKNPIVAGGQNYLAANISQFFDLKGPSILLDTACSSALVGLNMAIQALRSGDIEAAVVGGVSLLDAD AHRMFHERGLLCDKPSFHIFDKRADGVILGEGVGMVLVKTVNQAVEDGDSIYAVIKAAAINNDGRTAGPS SPNLEAQKDVMLSALEKSGKKTEEISYLEANGSGSAVTDLLELKAIQSIYRSESKAPLGLGSVKPNIGHP LCAEGIASLIKVALMLKHRQLVPFLSGNENMPYFDIEKTDLYFSRSQAEWKETTPAAAINCFADGGTNAH LIIEGWRDSAERPIRRKPLPLPELNRQPVLIKPSAQNVQKKVHSDTGASKDMFWKTFK PksM DH ACP KS8 DH KR MT ACP KS9 KR ACP KS10 ACP MITEQLHISLNNPIMSNHKVYGQALLPGLAYIDLIYQVFQEHGYAYQELELKNLTIFYPLIADESYDIAL TIHVSEREEGTWSIIIDGQKQHGESLSDKRQYETADMHRKEQTAFAESIDLNQWKSTADRILNLDEIYEQ CRSQELVHTGMMKAEGQIYEAKEGAVIDLAVGQEALRHSDAFLFHPTLIDGSGIGSSCLISDQTMYLPLY YESFSASERLQKGCTARILSSSVRQKKELTYMTIEYFNSAGQKVAELKQFAGKSVRNMSAFHSAKQIQEE RAAVSQNITRDYPAFEMYLRQLLAKQLERPAEQMDIHAGYYELGLDSSSLLTVVQEIGDKVGADLAPTLL FEFTTIAELAAHLADHYSIGEADDAVRQSPSPIDGVTSSPEIGEDIAIIGMAGRYPKAKNIQEFWEQLKA GTDCITEIPNSRWEWKESDGLDSPAGKPLSKWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWE AIEDAGYTPETIASPQGENKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNYAQIANRVSYYCNFHG PSMAVDTVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYCHTFGKGGDGY VSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQADVIEACLEKTGIDPRTISY VEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKSNIGHAEAAAGISGLTKTVLQLHHKTLVPSL HSEELNPYLKLDQTPFFVQHETKEWEQPSFTENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSE TILTKNEEIVIPLSARNKDRLQAYALKLLDFLSEDVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKL RAFANGEEEIEGCWTGRAKENQEAAGLASVNALNNNLIRDSEMMEMAKAWVQGKRVTWDDLYGDRKPLKI SVPTYPFARERYWISVPEMKTSTVNHILHPLVHRNTSDFTEQRFSSVFTGTEFFLSDHVVQGQKILPGVA YLEMAREAAEKAAGDLDGEQRVVSLKDIVWVRPITIESEPKEIHIGLFPEDNGDISFDIYSSSEHKEEAL TIHCQGRAVISDEAETSILNLSSIQTECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVGKDQLLAKI SLPAFLKNDKQHFALHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQEVDIFSPCPEKIWSYIRYS SDSKAENKVRKYDIDLCDENGRVCVRMKGASMRALDGEQHSKPQLLTDSQLTGHTVMIPVWEPVSLEAED NASFAGKRAVLCGAAEADRTFIKHHYPQISFVDIRPADDIEAIADKLQAYGSIDHVLWIAPSHRGSIGSD GQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQPVTQHEAVQPAHASIHGLAGTMAKEYPHWKIRLL DLEKGCTWPVNHMFALPADRLGHAWAYRNQQWHQQQLIPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWS EYMIRRYQAQIVWIGRSQLNAAIQSKIDRLSALGPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHS AMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQSHYASGCTFADA FAHQLSQSWACPVKVMNWGYWGNSEAAEDEHYVQLMNQIGLGLIEPAEAMKALEALLSGPVSQTAFIHTT KPVAVEGVNQNEFITLYPEQPSADAESLMERLPTTGRFQRVTHEELDDLLYRLLLGQLQTAELFDGYTLS VERLQQYKTREFYGKWIRQTSEFLLQHGYLKKVGDSLVRKDQAEDIELLWLEWNAKKEKWLKDSETKAMV VLAEAMLQALPDILTGKVPATDIMFPHSSMELVEGIYKHNQVADYFNKVLADTLLAYLDERLKHDPEASI RIMEIGAGTGGTSAGIFEKLKPYQKHINEYCYTDLSKAFLLHAEKEYGAENPYLTYQLFDVEKPIDQQEF EAGGYDVVIAANVLHATKNIRQTLRHTKAVMKNNGMLLLNEMAGNSLFPHITFGLLEGWWLYEDPAVRIP GCPGLHPDSWKAALESEGFESVFFPAEAAHDLSHQIVAASSNGLVRRMMKNVILPEKVVSQASNQEPAYI HTIDSEEAGQSKHALLREKSTEYMKKLIGETLKIPAGKIESSEPLEKYGIDSIVVVQLTNTLRKEFDHVS STLFFEYQTIDALVEHFIKTKTEALMKLTGLDRQVQQHTPAESRTQSSQKPDQAAKRTRRFRKLGFSGEK ETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDWKAYYDKEKGKEGSIYTKWG GFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYASIEDAGYTPDSLCSSRKIGVFAGVMNKNYPTGY GYWSIANRISYLLNFQGPSLAVDTACSSSLTAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNM LSASDTCKSFGDDADGFVDGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHAQAQV IKEAIERADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSKSNIGHCESAAGIAG LTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPVIGGQEVPRRAGLSSFGAGGSNAHI ILEEYIPRTGAQTPKDHPPALIVLSAKNMERLQEKAEQLLTAIKQKRYCETDLIRIAYTLQTGREAMEER LAFIAESLEDLERKLNDFIENKADSLYLDRIDDNKKALAVLSADEDTEKIIEAWMSKGKYTKLLDLWVKG LSFDWGMLYGTQTPVRISLPAYPFAKERYWAPGAAKAPVSIEQDHDQQTEEPFKVMTFQEVWKEEPATLT SKRIKTLICFLTEREKQNAFASALKNVDQDTKVIFISQGEVYSKQSEYSYQIVRQEPVTFEKAFQSIKEE LGEPDAILYMWPMEDKRCIKDHSCIVYLLQGMSAAKLHPSRLLLAGCFEDSLDRSYLESWIGFERSLGLV LPHTKVTGIFQPAEQGSMDDWTRKVWAELQASTEQTVLYQNLKRYVNHIEQTTIQPDNSKLKSGGTYLIT GGVGGLGYLFAKHLAKNYAANLILTGRSPFNDEKQKQIKELKDLGGERMYAEADVSDPIAMGDCVKRGKD RFGAINGVIHAAGIESDSAIFDKKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCC DYAIGNRFQMAYAQYRNELHNGKTFVINWPVWKDGGMKIGDEETTDMYLKSSGQRFLEAEEGIRMFEHIL AQQDAQHLVIAGQPSRVSRFLGMTEPAIPEPATQAPLAQENKDEVKTLSIEKRLEHDLKEHIHTLLKISK DRLNLNKNWADFGFDSIYLAKFSNVLSKHFNIEVTPALFFGYSTLQELISFFLTDHKELIEAFYRDDASE AQKPPEAYAVIPVALEPEASKKSIRQVHDEPIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERRD

WGRANRDPEKAVPRWGAFLKDIDRFDPLFFQISPKEAESMDPRQPIFLEEAWHTFEDAGYMGDRIKGKSC GVYVGVEEGEYAHLTGDTDYINGTQNATLSARIAYALDLKGPNMALTAACSSGLVAIHQACSALRQGDCE MALAAGVTLNISHMSFEALTRAEMLSPNGQCKVFDQDANGLVPGEAVAAVLLKPLSKAIEDKDHIYGCIK ASGVNYDGKTNGITAPNPFSQAELIENIYEKNEINPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQ KQFCMISSIKPLIGHTFAASGTVALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLCKENRSWIKKN QKPRMGTISTTGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQNDDRLQDAACRMIAYLEQNHNL SLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKEYVEAMKNGGVSGQQRSLYTGYTEGILEEQDEAVL QALAKERNLENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFARERYWISSGTQQSEAVKQHSQDMKTE IDEPNGKTHIQKIIVQFLARELGISEDRINFKRNFLDYGMDSILGRKLMRHIEKTTQLKMAGREILECQT VQALSDHLALKAEKQNHSAAAHHIKGTYTDEQIIGLMQEVALGKLDFKSVQNIIEGSKSYES PksN A PCP KS11 DH KR ACP KS12 DH KR ACP KS13 DH KR MKRQLKSPLSEGQKGLWMLQKMSPGMSAYNIPLCFRFSKPIHAETFKKALLFVQRQYPVLASVIQEENGI PFQSVQLSKDLYFVEEDISAMKSADIMPFLKEKAKEPFQLEAGPLWRTHLFHRLEECIVLITIHHIIFDG VSMLTLISALFEAYQQLLNGIEPLQQPSTADYYDFVDWENRMLTGREGEEHLAYWKEQLSGSLPVLDLPA DRPRSSARKFKGQAYKSLLPHHLRNQIKSFARTNHVNESVVFLSIYKVLLHHYTKQKDIIVGVPTMGRQE DRFETLIGYFINMMAVRSKNIGSQPLTAFIRELQLTVAVGLDHAAFPFPALVRELNVDRSAADSPVFQTA FLYQNFFQATGLQKVLEPYQTLGIEYIEDIRQEGEFELALEIYEQENETVLHLLYNPDLYELSSIESMME NYMKLAQHMMEDPSLPLEAYSLQLNQEQTSLLEQWNATGTNIANDKCIHEVFEEKAKQTPDAVAVMFEDR SLTYKEVDEKSTSVAVYLQHQGVRPEQPVGICAERSFDMIIGILGILKAGGAYVPLDPSFPQERLKYMLK DSQASIVLTQPNVHDRISGLTGSHVKAINIELACRNGYTDQQSSGLKREVKPEHLAYIIYTSGSTGEPKG VMVEHRSIMNTLNFLESHYPVTAEDAYLLKTNYVFDVSISELFGWFIGDGRLVILPPNGEKSPQLCMDYI ETYKVTHINFVPAMLHVFLEMAKDNKRFTEDGPLKYMMVAGEAFPKVLVKKAVSLFTNCRVENIYGPTEA SIYAAYFGCGKGDIASHHTPIGKPVSNTKIYIVDQHLKPVPIGKPGELCIAGAGLARGYFKKPGLTAEKF IDNPFESGTKLYKSGDSARWLPDGNIEYLGRIDSQVKIRGFRVELGAIETKLGEFPGILDQAVVVKQLEG HQQLAAYYTEESGHASANPKDLRLHLKSSLPEYMIPSHFIRLDELPLSPSGKVNRKELEKREIVFNRRKP NHLQLTEIEDQVLRIWEETLKVSGFGPEDGFFDAGGDSLLAVAVAERIKKEFDCEFHVTELFEYSTIRAI SEYILEMKNSDLAGTQNEDDHDDKKDGKYPKQKIPPYFDDSVAIVGISCQFPGAKNHHDFWNHIKEGKES IRFFSEEDVRANGVPEELIQHPDYVPVQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDA GYVAKEIPATSVYMSASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYFVHSN CSSSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFDASADGMAGGEGVAV ILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEVIQHVLDTTKIHPETVSYIEAHGTG TKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIGHLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNP DIKFESSPFYVVRERKSLEKHAGVHRAALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKN SERLQVYAKEMLSYISQDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAFVTGKPLAEGC IQGEKTRMTSAEQLLGNAEADDMASSRISKEELRKLAEMWANGFHVEWRRLYPNIKPRRISLPTYPFAEE RYWPESSTGAITTIEPSRLHPLEHHNTSVLSEQRFSSIFTGQEYFIAEHIIKGMAILPAAVTLEMARAAI EQGIGGLEDHETGIRLKNVVWVRPVVAGSEPVQVNIGLYDEDGGHIAYRMYGDPESADAEPVVYNQGKAE LIQLKREKALDLSKIKKQCDQSKMDAASFYEGMIGADYGPGYKSVEAVYKGDGQLLAKLSLPESVAHTLG DYVLHPSVMDGALQAAEYLQNVVRAELSDTEDFKAALPFALEELEVFRQCVSDMWVYVQFNSKNKPGDLI QKVDIHLCDEHGMICVRLKGFSTRVMEADIQTEPSKINAETLLLQPVWQEQKAANSLAAKKYAEHLVFLC EYDHETRKQIEAAIEDVHVYSLEARPSSVDGRFHSYTEQVFKKVQEIIRTKPKDGILVQIVTSAEGEQQL FSGLTGLLKTACQENAKLTGQMIEVSSEESGESIAGKLLENQMSSDSYVKYQNGTRYIADWREIKQAKGD GSKPWKDNGVYLISGGAGGLGHIFAKEIAEQTKNATVILAGRSPLSESKSKKLKELHSKGADITYRQTDV TNKIEVYQLIDDIQKRYGRLNGILHSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPLDFFI LFSSLSGSLGSIGQSDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRDGGMQVDQETEKRLVQL AGIVPMRAEKGIQALYQALHSEANQVMVIEGDVQKIKQNMLAKNASAPMEKKEAEHMTEQINSIDADSLL DKVKAMLKREIAKLLKVKLETIDDHAEMTVYGFDSISMTEFTNHINRAYQLELTPTVFFDHPTIHAFGKH LSEEYQSVFAKTFAVRAVSAQLQPAAKQEQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPM AKDVEAYWNILKEGKDCMTEIPKDRWDWREYEGDPAKEVNKTNVKWGGFIDGIADFDPLFFGISPREAEQ MEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSAIEGSAAANTSPSVGPNRV SYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMALAGGVNTIILPEVYISFDKAGALSKEGKCKT FSNQADGFAHGEGAGILFLKKLKAAEEAGDHIYGVIKGSAINHGGRAASLTTPNPKAQADVIQSAYQKAG IDPKTVTYIEAHGTGTELGDPVEINGLKSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIK ILLQLKHKTLVKSLHCENVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIGGVNAHVII EEYIPEASDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYSDVNLARIAYTLQAGRDAMEE RLGIISGSIEDLQKKLKDFAAEKSGVEDVFKGRIDKGTLQMLTEDEEIQEAVEKWMERGKYAKLLELWVK GLDVDWTKLYGENLPKRISLPTYPFAKDRYWISDHIEKSGSIDANQAASRLGGAVLHPLMHQNTSNLSEQ RFSSIYTGEEFFLADHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVVEDQPQQV HIRLLPGENGEISYEIYGHSDVTGEQSIVYSQGSAVLNPAENLPAVDLQSLREQCQESHFSVNEVYDTYR MIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYKMHPGLMDSALQASSILTGAGDNQLTLPFA VQELEVFGACSSEMWVYARYSQGSKATDKVQKRDMDILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLA TLMFEEKWVPKDFKKESPEPHYERHIVMLCDMNGLSKDRIESRMTGAECIVLESFREGLAERFQDYAEQA LETVQGLLKSRPQGNVLIQLLTSAQRKQYSFSGLSALLKTAGLENKKLIGQTIEIDSHENVESVIEKLKE

NKRHTEDQHIKYEKGKRYINDLDEMQIDDREISMPWRDKGVYLITGGAGGLGFIFAKEIARQAEQPVLIL TGRSALNADQQAELNELQQLGARAEYRQVDVTQTEAASELITSITSDYEDLNGVIHSAGLIKDNYLMSKT NEELTQVLAPKVKGLVNVDEATEHLALDFFILFSSISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMY RHGQTLSINWPLWKEGGMRANKEIENMTLKNTGVTPMRTETGIQALYKGLAFGKDQVIVMEGFKDMMREK LTQKPSSDDVPMKTVQVRVTSEARMDQGNMFDHIQEVLKQTISQLLKIKPEEIDPDMEFNQYGFDSITLT EFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNAFTAQTPAKAEVLMQPVEQNIKNMTFSTENRF VKPSVTPMQKEADHKPEPIAIVGMSGVFPKAKDVEEYWKNLSSGADCITEVPKDRWDWQEYYGDPLKEAN KTNVKWGGFIDEVADFDPLFFGISPLEAEQMEPQQRLLMTYAWKAVEEAGHSARSLAGTKTGIFIGTGNT GYSSLLSNVDIEGSAAANMSPSAGPNRVSYFLNIHGPSEPIDTACSSSLVAIHHAVCAIENGNCEMAIAG GVNTVVTPQGHIAYDKAGALSKEGRCKTFSDKADGFAVSEGAGILFLKKLTAAERDGDHIYGVIKGSAVN HGGRANSLTTPNPKAQADVVKTAYEKAGIDPRTVTYIEAHGTGTELGDPVEINGLKAAFKELYEKTGDPA VHGSHCGLGSAKTNIGHLSLAAGVAGVIKVLLQLKHKTLVKSLYSETVNPYIRLDDSPFYIVQESREWQA LRDEAGRELPRRAGISSFGIGGVNAHVVIEEYIPKETTHPATAPAVTAQHPGIFILSAKDEDRLKDQARQ LADFISKRSITARDLTDIAYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEGGTNAKYMYRGRAEKGIA QTLRSDDEVQKTLNNSWEPHIYERLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWITDTKEEA AAHQTALKTVESAALHPLIHVNTSDLSEQRFSSAFTGAEFFFADHKVKGKPVMPGVAYLEMVHAAVTRAV RRTEDQQSVIHIKNVVWVQPIVADGQPVQVDISLNPQQDGEIAFNVYTEAAHNDRKIHCQGSASIRGAGD IPVQDISALQDQCSLSTLSHDQCYELFKAIGIDYGPGFQGIDRLYIGRNQALAELSLPAGVTHTLNEFVL HPSMADSALQASIGLKLNSGDEQLSLPFALQELEIFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRV CVRIKGITSRLLEEGIQPPDGPTSLGNSKATLNGALLMAPIWDRVQLEKRSISPADERVVILGGDDNSRK AVQREFPFAKELYIEPNASIHRITGQLEALGSFDHIVWMSPSRVTECEVGDEMIEAQDQGVIQMYRLIKA MLSLGYGQKEISWTIVTVNTQYVDQHDIVDPVDAGVHGLIGSMSKEYPNWQTKLIDVKKYEDLPLSQLLS LPADQEGNTWAYRNKIWHKLRLIPVHNNQPVHTKYKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIG RRKKDAAIQSKLDRFARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIVLQDRSLMNMSEE CFRNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAAGCSFKDAFAQRLSQVWPCTVAV MNWSYWGSIGVVSSPDYQKRMAQAGIGSIEAPEAMEALELLLGGPLKQLVMMKMANETNDEAEQTEETIE VYPETHGSAIQKLRSYHPGDNTKIQQLL PksR MT ACP (KS14) DH ACP KS15 ACP TE MLNTEDILCKMLFAQLQSIGFFTESKSQPVLENFYGRWFEESQSILERHQFLKRTENGHVPTRSIGTMSE LWKEWNEQKFDLLQDNNMKAMVTLVETALKALPEILTGKASATDILFPNSSMDLVEGVYKNNQVADYFND VLADTLTAYLQERLKQEPEAKIRILEIGAGTGGTSAAVFQKLKAWQTHIKEYCYTDLSKAFLMHAENKYG PDNPYLTYKRFNVEEPASEQHIDAGGYDAVIAANVLHATKNIRQTLRNAKAVLKKNGLLLLNEISNHNIY SHLTFGLLEGWWLYEDPDLRIPGCPGLYPDTWKMVLESEGFRYVSFMAEQSHQLGQQIIAAESNGVVRQK KRTEAEEDPSHIQMNAEIDHSQESDSLIEQTAQFVKHTLAKSIKLSPERIHEDTTFEKYGIDSILQVNFI RELEKVTGELPKTILFEHNNTKELVEYLVKGHENKLRTALLKEKTKPAKNEAPLQTERTDPNKPFTFHTR RFVTEQEVTETQLANTEPLKIEKTSNLQGTHFNDSSTEDIAIIGVSGRYPMSNSLEELWGHLIAGDNCIT EAPESRWRTSLLKTLSKDPKKPANKKRYGGFLQDIEAFDHQLFEVEQNRVMEMTPELRLCLETVWETFED GGYTRTRLDKLRDDDGVGVFIGNMYNQYFWNIPSLEQAVLSSNGGDWHIANRVSHFFNLTGPSIAVSSAC SSSLNAIHLACESLKLKNCSMAIAGGVNLTHDLSKYDSLERANLLGSGNQSKSFGTGNGLIPGEGVGAVL LKPLSKAMEDQDHIYAVIKSSFANHSGGRQMYTAPDPKQQAKLIVKSIQQSGIDPETIGYIESAANGSAL GDPIEVIALTNAFQQYTNKKQFCAIGSVKSNLGHLEAASGISQLTKVLLQMKKGTLVPTINAMPVNPNIK LEHTAFYLQEQTEPWHRLNDPETGKQLPRRSMINSFGAGGAYANLIIEEYMETAPEKEHIAPRQQEFTAV FSAKTKWSLLSYLENMQLFLEKEASLDIEPVVQALHRRNHNLEHRTAFTVASTQELIEKLKVFRTSRESS LQQGIYTSFDLQPCAESASRDREINAAEQWAQGALIAFKEADIGNRTGWVHLPHYAFDHNTSFHFDVSSI NEKSSDVEDNINQPVIQDQFTYDEPYVQGHVFNNERVLVGATYGSLAIEAFFNLFPEENSGRISKLSYIS PIVIKQGETIELQAKPLQKDQVIELQIMYREPSSGLWKPAAIGQCGIGSFEPKKVNIENVKHSLTKLHHI DQMYKTGNGPEWGELFKTITHLYRDHKSILAKIRLPQSGLANGHHYTVSPLMTNSAYLAILSFLEQFDMT GGFLPFGINDIQFTKQTIKGDCWLLITLVKNTGDMLLFDVDVINESSETVLHYSGYSLKQLRISNQRGNQ NKAIKASNLKARIRSYVTDKLAVNMADPSKLSIAKAHIMDFGIDSSQLVALTREMEAETKIELNPTLFFE YPTIQELIDFFADKHEASFAQLFGEAHQQEERPAQIENQMKQIPAYETNTDKTIEHAADGIAIIGMSGQF PKANSVTEFWDNLVQGKNCVSEVPKERWDWRKYAAADKEGQSSLQWGGFIEGIGEFDPLFFGISPKEAAN MDPQEFLLLIHAWKAMEDAGLTGQVLSSRPTGVFVAAGNTDTAVVPSLIPNRISYALDVKGPSEYYEAAC SSALVALHRAIQSIRNGECEQAIVGAVNLLLSPKGFIGFDSMGYLSEKGQAKSFQADANGFVRSEGAGVL IIKPLQKAIEDSDHIYSVIKGSGVSHGGRGMSLHAPNPAGMKDAMLKAYQGAQIDPKTVTYIEAHGIASP LADAIEIEALKSGCSQLELELPQEVREEAPCYISSLKPSIGHGELVSGMAALMKVSMAMKHQTIPGISGF SSLNDQVSLKGTRFRVTAENQQWRDLSDDAGKKIPARASINSYSFGGVNAHVILEEYIPLPKPPVSMSEN GAHIVVLSAKNQDRLKAIAQQQLDYVNKQQELSLQDYAYTLQTGREEMEDRLALVVRSKEELVIGLQACL AEKGDKLKSSVPVFSGNAENGSSDLEALLDGPLREMVIETLLSENNLEKIAFCWTKGVQIPWEKLYQGKG ARRIPLPTYPFEKRSCWNGFQAVENTPSVSQDERINNSSDHHILANVLGMAPDELQFHKPLQQYGFDSIS CIQLLQQLQSKVDPLIVLTELQACHTVQDMMDLIAKKQEDTSLQNDQARTFPELIPLNDGKRGRPVFWFH GGVGGVEIYQQFAQKSQRPFYGIQARGFMTDSAPLHGIEQMASYYIEIIRSIQPEGPYDVGGYSLGGMIA YEVTRQLQSQGLAVKSMVMIDSPYRSETKENEASMKTSMLQTINTMLASIAKREKFTDVLISREEVDISL

EDEEFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVKPLPDPETVKCYYFRNKSRSFFGD LDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDVDSSNHFMILTEPKASTALLEFCEKLYSNRGVVNAN FLKAFRKKHEAREEKETDELVKR Bryostatin BryB ER KS1 MT ACP KS2 DH KR ACP KS3 KR ACP KS4 OMT? ACP MVVVEEFFVSYRDILKALQDEKISFEEAKYKLIKRKDKKSKQRLNHDRELNRSMKITPKIVNNYGLVLLG GHLFEELRLSEWKAANPNPNEVSIQVKASAISFTDTLCVQGLYPSHYPFVPGFEVSGVIRQVGEHITDLH VGDEVIAFTGSSMGGHAAYVTVPQDYVVRKPKDLSFEDACSFPLAFATVYHSFARGKLSHNDHILIQTAT GGCGLMALQLARLKQCVCYGTSSREDKLALLKQWALPYVFNYKTCNIDEEIQRVSGHRGVDVVLNMLPGE HIQQGLNSLAKGGRYLELSMHGLLTNEPVSLSSLRFNQSVQTINLLGLLNKGDDGFIGSVLAQMVSWIES GDLVSTVSRIYPLDQIGEALRYVSEGEHIGKVVVSHTATEPMDCRQRCIDNVLKQGQMAALTATGGKSRV WGGTGVNDKPSPAVGIEERLLEGIAVIGLSGQYPKSKTLEQFWQTLADGVDCISEIPADRWSLEEYYSPI PEGGKTYCKWMGVLEDMDCFDPLFFAISPREAEVMDPQQRLFLENAWSCIEDAGINPKMLSRSRCGVFVG CGANDYSALMNSSHSTSLELMKELGNNSSILSARISYFLNLKGPCLAIDTACSSSLVAIAESCNSLVLGT SDLALAGGVLLMPGPSLHIGLSHGEMLSVDGRCFTFDQRANGFVPGEGVGVVLLKRMSDAVRDGDPIRAV IRGWGVNQDGRSNGITAPSSKAQSALEQEVYQRFNIDPSSITLVEAHGTGTKLGDPIEVEALAESFRVYT DKRHYCALGSVKSNIGHLGVGAGIAGVTKVLLSLQHRMLPPTIHCEDVNPQIALEGSPFYINTELKPWQS GDSIPRRAGVSSFGFSGTNAHLVLEEYLPHSTGTIESFAANHASTVIIPLSAKSHNSLYTYAQTLLIFLK RSQVTDAKKITIDHMECRLLDLAYTLQVGREAMDKRISFIVNTKQALVEKLNAFLEKEKTITDCYHYLFD SDKPSTEIFRLDEDDKVLINSWISQSQYHKLAEAWSQGLDIDWTLLYTHSSTPRRISLPTYPFARDRYWL PEKPRYNAANHPVSNHQTTTQNHSRFAIDTDHDVVAEIMQKTHQQELEQWLLKLLFVQLQHMGLFQHRVF ETATALRQSAGIVDKYDRWWHECLSVLQDAGYLEWKDDSVAAAQALESESQEAWWSRWNTEYKHYQNDPE KKTLAILINDCLQALPGVLSGEQLITDIIFPNGSMEKMEGLYKNNRIADYCNQCVGDLLVQFIEARLSRD ANARIRIIEIGAGTGGTTAIVLPMLQAYQDHIDTYCYTDVSKAFLMHGQEHYGEQYPYLSYCLCNIEQDL VAQGISVGDYDIAIAANVLHATRNIHETVSHVRQALAANGLLILNEFSQKSVFSSVIFGLIDGWALSEDT GLRIPGSPGLYPKQWQAVLEASGFGDVEFPLHDARELGQQIILATNAHANVASDLATSVIDHAPKRLPSA EVSMDERVSHDAMMKASVKQLLVEQLSQSLKLDMNEIHPDESFADYGVDSITGASFIQQLNDTLTLTLKT VCLFDHSSVNRLTAYLLSDYGDDIAQWLATAPALVDHPQSVVSQVLPERSPASTQAKPLPSVPPSLSMES PVQQESIAIIGMSGRFAASENLEAFWQQLAQGVDLVEPASRWGPQAETYYGSFLKDMDQFDPLFFNLSGV EASYMDPQQRCFLEESWNALENAGYVGDGIEGKRCGIYAGCVSGDYAQLLGDQPPPQAFWGNASSIIPAR IAYYLNLQGPATAVDTACSSSLVAVHLACQALHLDEMEMALAGGVSLYPTPSLYESLRGADMLSSRGRCH SFDACADGIVIGEGVGVVVLKRLSAALADGDHIHGVIRGSGINQDGRSNGITAPSAQSQERLERWVYDRF DVNPEHIQMVEAHGTGTVLGDPIECEALTRAFRHYTDKEQYCAIGSVKTNMGHGTMVAGMAGLFKVVLSM QHRQIPPSLHFTQGNPNIDFDRSPFYVNTELRDWSVGEGETRCATVSAFGFSGTNAHAVIEEAPPVVRQH EEQPGYLVVLSAHSDDQLRQQVENLCGYCEHHPELDVGNLSYTLLLGRQHWSHRLAGVACDLEDLRRSLD QWLGQGKAPRVYVSALAEGEPRLQVSLQHVGNECIRACSESCSANHYVDALSTVGDLYVQGYPLEYGVLF AQGYGRIPLPTYPFARQRCWVPQTISHSTVDAISQHAFLHPLLHRNTSDFSCQRFSSTFNGSEFFLTDHL ILGKKILPGAAYFEMVREAIKQACGFLDNSEVVIQLNDIVWTKVIAVDDDIKEVHIDLFVENGSESCLTH EFDRQNISLNYEVYTQNSEGNGRQNKKIIHNHGMVTLSSLNTTEVVDLDELRSHINQASLNAEQCYLAFE SIGVQYGDRHRCIDTVYIGEHQVLAKLSMPEIAGDLDKCFVLHPGMVDSALQATLGITSDINDIMLADRQ ADYILTPKSTLPFALEKLEIIGKCTDSMWVWIRNSLSTDQKSPRSAVNDIQHLDIDLLDAQGKVCVRMRG FLSRVLPNNVNSLAEEPFTALNNSSTLLFHPVWRSQTLSSGNNLPNDARHLVLLYDLNMTNVEIEDVEFI DLHSKHLDLQDRYCDIALQVFEIVKDVMIDKSVQPVLIQLLVPNDGEQGVFTSLLALLKVARSENPKVIT QLIQVQSPQTSQNLLRIITENSHDITHAEIRYHLDQRECLVWEAVPNLQKPYSTPWKSNSVYLITGGTGG IASQFVKAIAVSTTKSVLILVGRSPLNDEKKSYLLELESLGTIIKYYQTDVSQQDQVKALIKEIVQQYGQ LNGVLHCAGIVNDNFILKKTSTEYKEVLLSKVSGTVNLDQATQSIELDFFILFSSISAVFGNAGQSDYST ANKFMDEFARYRNALVNRKERYGLTLSINWPYWREGGMSIEENFENIMQENTGMSALETSQGIEVLQRAW QLQYTQLLVMVGEMKRMESFLHKQGFEQIPVVSADTVSENKTSTIENLSADVDTLPFIEVQAYNMEQKTL DYLKNVFATTTQIPEKNIYVHETLDKYGVDSLLVMKMTNQLEKVFGKLSKTLFFEYQTIRELGDYFLKFH DEKLREFFQIDSKLSMLNNHGEIEVQKKGDEPSVGDRYKSADACLSRFISPVSAVNHQQKNVNNVPISSA VMDIAIIGLSGRYPQAENMEEYWENLCQGKDCITEIPKERWDWQDYYTDDPYQPGGHRSKWGGFIRDVDK FDPLFFNISPSEVELTDPQERLFLESAWAALEDAGYCRDYLQMLSSRTKSSFSSGDVGVYVGVMSSEYQL FAFEQNLRGHPISSVGSYASIANRVSYVLDLHGPSMTVDTMCSSSLTTLHLACQDLKLGRTDLGIVGGVN ITIHPNKYQALSHAQIISTSGRCQSFGEQGQGYIPGEGVGAIILKRLVDAERDGDHIYGVVKGSAVNHGG KTNGYNVPNPNAQQQVVSRALREAAVNPHHVTYIEAHGTGTQLGDPIEITGLNKAFNSLTNELGLSAVAK QSCLIGSVKSNIGHCESAAGVAAISKVLLQMQHGQIVPSLHSKALNPNIDFTVTPFVVNQGLLDWKRLEV EGKRVPRIAGISSFGAGGSNAHVVIEEYVASNEKQEDFQGKVIIPLSAKTSDQLQEIVDRLLKFIEKNEQ KGREIRLIDLAYTLQLGREVMEERLALIVESIPMLKENLARFKYSENDAQFFDTIKDIYRGRTRPGALDF AIFSEDEDMANTLDIWIQKGKYFKLAELWVKGVTIDWNKWYNALLTQNKYLKPRRISLPTYPFSRDRYWI PSAFPQQTFSTVIEADANQTLNELLCFEEKWQVQSELHDSVADQSHVINTLICFLTEKEHQKALQQSISF HSPKTRLIFISQAQAYEQYSSDHYAVNPEIGKTYQQAFQHIVKSIHKSDVTDIMYLWALEDERWITSPLP IVYLLKSIEVSLLKPEKLLFVGEFKTSLQRCYLESWLGFERSLGLVLPDIEVAVLLEAVEGTQSHTVTKQ MDLWIEKLWSSLKAQKVHSSLYQNGRRYFLKTQPLQLVMNQSIQCLQGTLLITGGCGGLGFVFADYFSKT

YKINLILVGRSDLDKEKQSQIQALEKSGSRVAYVQTDICDEKNLQLELDIAQKYCGPIQGVIHAAGIIDQ KTIFEKSPENFQAVLAPKIQGTLILDNVLSAQSLDFICYFSSSSALLGDAGSCDYAMANRFLMAHAQYRN TLVSEGKRKGKTLVIHWPAWNVKGMGLNGLDENVKTEFYLKSSGQRLLDIKEGCELLNTLLAQDYSQCLI LAGRKNRIYQFLGLTQDVSTSQVSQGQEVMNLQQDLDSNKRAEIEDLSVEECIILDLKTLITEQLKIPSA HLDVESNLADFGFDSVSLANFSRALSIHYHFNITPSVFFGYPTIERLSRYFLKEHTALMEAFYQQKKTSN SNNTLSVIVPHVKEKPTTDLISSNASPSIADPLPPQAIESIDEPIAIIGMSGRFPEARTVEAMWEILSEG KSAVQEIPIERFNWHEYYEHPSDDVRKTNSKWSACIPGIKEFDPQFFEISPREAKKLDPLQRHLLQESWN ALENAAYGKLHIDNKTMGTFIGVEEGYYKNLLNEDEATLNHNAILASRLAYFLDFNGPTMAINTACSSGL VALHQACLSLRQQECDTAIVAAANLIFTPQVYVGMTQAGMLSPDGKCYTFDQRANGIVPGEAVVAIVLKR LSRAEADGDPIYASIRGTGINYDGKTNGITAPSGTAQTRLLKNVYKRAQVNVEDISYIVTHGTGTKLGDL IEVNALYDAFKSETRKQGYCALTSAKTNFGHTFAASGLLSLVNLVQAFQHDQIPASLYCEKENDYIQWSS SPFYVNKHNKPWPRQSGKPRLGAVSAFGMSGTNAHIVLQEYPDEVKNVSYKAPYFLLVLSAKTEIALQER LSSLLGALQYEPIKKQAMARIACTLQTGRYHFQYRCALVVKDRDEAISCLQQVSGSENPAHYLTGKVVRG LSKEKESDEYIQDLLQQTSLLKGNPKQYQEVLLTLANLYCKGYDIHWQSLYQTLPKRLHLPVYPFSRSHY WVNEDHQRHSSISQIKTETLREKKELLMLPDYIQRPDEVNTSVSLLDASQAWSAINTNAEHNSLSSVLNK NDPLNDLKSALSTRVDGMIPTLNRTGVMTENLNNYSQAFIDYVGKNKGEVLDLGCAYGIATIKALEQGAQ VLAVDMEKQHLDILSDRVRDEIKNRLSTQVGILPDIGFEEERFSAIHASRVLHFLTPQEIQQILGKMYRW LKPGGKLYLVTDSPYMGYWSSKAQDYENRKDAGDLWPGYIEDVNACFDKETVAGAPSAINPLDPDILQRE CKAAGFYVEKSEFFTGIEFARATDSESMGKEHVGVVAYKGPTVSSSEKEIEISLPEIKKDISLQKIRSLL RESLALELDLDADELDESISFTELGLDSINGVIWIRKINSHYELSITVSKVYDYPNIIELAEFLKQKIEQ KNDIQNLSSSSYFSEDNQEVALSLKEILKKVEGNTLSIDKAEKLFEQFSLK BryC ER KS5 DH DH KR ACP KS6 MT ACP KS7 KR ACP (KS8) ACP MKAKVIFQGLKSNEISIEQAEKMLLSLDTESKHGHPESKLSDIKSDLHDDYALVLLGGHLFEELRLSEWK AANPNPNEVSIQVKASAISFTDTLCVQGLYPSHYPFVPGFEVSGVIRQVGEHITDLHVGDEVIAFTGSSM GGHAAYVTVPQDYVVRKPKDLSFEDACSFPLAFATVYHSFARGKLSHNDHILIQTATGGCGLMALQLARL KQCVCYGTSSREDKLALLKQWALPYVFNYKTCNIDEEIQRVSGHRGVDVVLNMLPGEHIQQGLNSLAKGG RYLELSMHGSLTNEPVSLSSLRFNQSVQTINLLGLLNKGDDGFIGSVLAQMVSWIESGDLVSTVSRIYPL DQIGEALRYVSEGEHIGKVVVSHTATEPMDCRQRCIDNVLKQGQMAALTATGGKSRVWGGTGVNDKPSPA VGIEERLLEGIAVIGLSGQYPKSKTLEQFWQTLADGVDCISEIPADRWSLEEYYSPIPEGGKTYCKWMGV LEDMDCFDPVFFAISPREAEVMDPQQRLFLENAWSCIEDAGINPKMLSRSRCGVFVGCGANDYSALMNSS HSTSLELMKELGNNSSILSARISYFLNLKGPCLAIDTACSSSLVAIAESCNSLVLGTSDLALAGGVLLMP GPSLHIGLSHAEMLSVDGRCFTFDQRANGFVPGEGVGVVLLKRMSDAVRDGDPIRAVIRGWGVNQDGRSN GIMAPSSKAQSALEQEVYQRFNIDPSSITLVEAHGTGTKLGDPIEVEALAESFRVYTDKRHYCALGSVKS NIGHLGVGAGIAGVTKVLLSLQHRMLPPTIHCEDVNPQIALEGSPFYINTELKPWQSGDGIPRRAGVSSF GVSGTNAHLVLEEYTHRVTSPLQNTILPQNGLFIVPLSAKNDECLNACVERLLFFLKSRQSDTYKKYSLS DTAPILLDLAYTLQVSREAMTKRVAFVVKTTIELMEKLNAFIEKQNTIKASNIKGCYYSSTKTSSPFDNE STDHSPELWINKGSYDKLANAWCQGLYFDWNKLYNNAIKPRRIHLPTYAFARDRCWLPEKILRKRTNKNS SNTVEKLSLISTLHPLLHKNTSDWYGQKFTSIFNGEEFFLRDHVVQGKKMLPGVTYLEMARAAVQQSIGL CEDKKISIQLNNVIWKSPIEIGFNQQEVNIRFYRDKQIPIRESIDEQITYEIYTGPADPSDLKTSLRCQG VATFSFCDKYSAINIEKSLDIPHLKSQLSQESLDIKQCYEHFKQTGMYYGLSHQAIDALYIGDYQVLAKL SLPECVKDTQTQFVLHPSLMDSALQASIGLSTVIDINETDQPTPTFTSALPFALENIDIIKECTASMWAW VRTSKVYTDTSKIRKLDIDLCDEQGNISVSMKGLSCRIFNENAHSSEYSSTVVKDKEDRLEHPLINIIKN ENKYPVEKAHYISCFTGNESFLLDHGHVLPGVIYLEIICAATKIFTNQDVIIIKNIVWNKPIKIESDREV SIYLNKINDCYEYQITTLNSVQGDVLHSQGKILVGSRSNIKPPSDLKIEDIQSRCTVSIEPEKCDELISK NDQGPSILSIENLCHNDCQMLARLKIPSSFEKENKQYLLCPSLMHGAVLSTVALSLIQEGKKRGVLFPYS MKSMHIYAELSEVDYAYVRKSKVEHAKKYDIDLISAEGKVIVSIKELTLLSLKNKLEKNVIHASVKWQEH PLPDKKIDASIYSPIVILADKDPNLKVLLNQIWPNTHIKTLPSFDENTYQSIEKNFIYIIGELKNIFKNN LNKKQPFFILIKENNESYRHSAFAGLLATANEENTKFRGKVIHYPCNGDSQWNSYFVNSLQSEALSFDGH FEVRYSISGTREVKTVFEVDLKPNNKDMKYLKQGDVVWITGGMGSLGQIFAKEFVRMGITVILSGRSELS EENCNILEDIKDQGTEVVYKKCDVGNKESVKNLLSYISEKYNRLNGIIHAAGIIHDATLKKSDEQKIRKV LEVKISGILAIEEASENIDLDFMVLFSSLAAFGNPGQASYAGANAFLDGFTEYRQQLYEQGKCLTKTFCL NWPLWKEGGMSVDEHSETLMRHNSGMVPMDTQVGLDTLKWTLSGEYSQILSAQGNLEKIREILFSPLPII DDVANEKKKKVELGGKVKSDVDLGVIKQKITKVISDLQKINIEKIECDIELSEYGFDSVSFTEFANILNK QYRLELMPTLFFEHPTIASISHFLLEKYPDNFLEQAKPPKNIYDLDSIKPLKEKSTPDISFDPIKRIPTT PLSISSTDEKANDRHSKEYEPIAVIGMSGRFPKSADLNELWEHLHCNRDLVSEVPDDRWDWRDFYGDPQQ EPGKTKVKCGGFMDDIDCFDPLFFGISPIEAESMDPQLRVLLETVWACIEDAGYRASYLSGSQTAVFVGV SAEDYKELCHKTEWEKGIRVLSMLFHSAIPNRISYILNLHGPSEPIDTACSSSLVAIHRAIESIRQGSAE MALVAGVNIIASPSLTISGDQSGMLSEDGRCKTFDATANGYGRGEGVGVVFLKPLSKAIADKDQIHGLII GSAENHGGKATSPTAPNPLAQQALLKAAYQKSNLDHRTVTYIEAHGTGTELGDPIEINALKSTFADLDKS CGYADFKKDHCALGSIKSNIGHLESAAGISGILKVLLMMKHKKIPGNVHLNNQNPYLQLQDSPFYLSKDT HDWKSVLDEYQNPIPRRAGVNSFGIGGSNAHIILEEYHTEDIVRDDVYAKENTLAIIPLSAKKSQYLYKI ASRLLRFIQINTLYPCDLFDLAYTCQVGREAMDKRLVFVVKSIQELEDKLKKFIAYSDANSQNKEQQRGF DFYQTAENSNSDHLTFLWDDEDTVTLLSQWVNKGKYHKLAEAWSQGLDIDWTLLYTHSSTPRRISLPTYP

FARDRYWLPEKPRYNAANHPVSNHQTTTQNHSRFAIDTDHDVVAEIMQKTHQQELEQWLLKLLFVQLQHM GLFQHRVFETATALRQSAGIVDKYDRWWHECLSVLQDAGYLEWKDDSVAAAQALESESQEAWWSRWNTEY KHYQNDPEKKTLAILINDCLQALPGVLSGEQLITDIIFPNGSMEKMEGLYKNNRIADYCNQCVGDLLVQF IEARLSRDANARIRIIEIGAGTGGTTAIVLPMLQAYQDHIDTYCYTDVSKAFLMHGQEHYGEQYPYLSYC LCNIEQDLVAQGISVGDYDIAIAANVLHATRNIHETVSHVRQALAANGLLILNEFSQKSVFSSVIFGLID GWALSEDTGLRIPGSPGLYPKQWQAVLEASGFGDVEFPLHDARELGQQIILATNAHANVASDLATSVIDH APKRLPSAEVSMDERVSHDAMMKASVKQLLVEQLSQSLKLDMNEIHPDESFADYGVDSITGASFIQQLND TLTLTLKTVCLFDHSSVNRLTAYLLSDYGDDIAQWLATAPALVDHPQSVVSQVLPERSPASTQAKPLPSV PPSLSMESPVQQESIAIIGMSGRFAASENLEAFWQQLAQGVDLVEPASRWGPQAETYYGSFLKDMDQFDP LFFNLSGVEASYMDPQQRCFLEESWNALENAGYVGDGIEGKRCGIYAGCVSGDYAQLLGDQPPPQAFWGN ASSIIPARIAYYLNLQGPATAVDTACSSSLVAVHLACQALHLDEMEMALAGGVSLYPTPSLYESLRGADM LSSRGRCHSFDACADGIVIGEGVGVVVLKRLSAALADGDHIHGVIRGSGINQDGRSNGITAPSAQSQERL ERWVYDRFDVNPEHIQMVEAHGTGTVLGDPIECEALTRAFRHYTDKEQYCAIGSVKTNMGHGTMVAGMAG LFKVVLSMQHRQIPPSLHFTQGNPNIDFDRSPFYVNTELRDWSVGEGETRCATVSAFGFSGTNAHAVIEE APPVVRQHEEQPGYLVVLSAHSDDQLRQQVENLCGYCEHHPELDVGNLSYTLLLGRQHWSHRLAGVACDL EDLRRSLDQWLGQGKAPRVYVSALAEGEPRLQVSLQHVGNECIRACSESCSANHYVDALSTVGDLYVQGY PLEYGVLFAQGYGRIPLPTYPFARQRCWVIEKEVASKRDQQTVSTQAVHREPPVKLTHEPTTLLCQPVWH LQEAPDEARLEDSNADRLIILCEMNTADLQINTIKNIPVVHLHSTESQVSTHYCDIAAQAFATIKALLKQ KTNTQTLIQILVYTQEKQQMLGGLLSLLKTAQIENPKISGQLIELDREVTLEALIKILEVNRNTQIVSRI RYEAGQRKIEKWKEVTEINTLKKVPWKNGGIYLMSGGAGGIALSCARVMAQQIREPVLILTGRSALTESK RTYLKELTSLGAKVLYRQMDVSKSNEVESLVKHVVKEYGRLNGILHMAGIIQDNFILMKTVEEFKSTLSP KVTGTVNLDQATKNINLDFFILFSSISSVYGNMGQSDYATANAFMDEFSEYRNTLVSYKERSGKTVSINW PYWQEGGMRLSLDRENQLKNDVGLVALTTEHAIAALHQSLSLPASQVLIMFGYREKIRQSFWNENPQENQ PTDDTVNPQLNNISLQDQVLQKFKELLSEHIQVPAERLGSQQKFESFGIDSLIINQLNKDLSLVFGEISK TLFYEYRTLIELVDYLIAEYPEQSKHWLGQPQESPSSDQLLSLELSGKTQQKTTEDVNIVHPIKKSEQEA MAVIGMSACYPSAKNLDQYWENLKCGKNCITEIPDDRWSIDGFFCPDVEEALSQGKSYSKWGGFLEDFAA FDPLFFNLSPRDAMRIDPQERIFLQECWRAFEDAGYVCSRLSPELRHKTGVYGAMTKINPNTSFASLVNR VSYIMDLHGPSVPVDSMCSSSLVALHQACESLRQGTIDMALVGAVNLYLHQDIYLGMCQAKVISDSATPA IFGCDGKGFTPSEGVGAVVIKRLSDAEKGNDRVLAVIRGSAVNHSGRTNHYGVPCPRQQAAVIHEAIDNA NVDPRSIAYIESAANGSEMGDAIEMSALTKVFQTHRDNGKAQYSIGSLKSILGHGEAVSGMAQFMKVVLQ LRNKSLCPSPDPQQKNPNIHFENLPFELQTELDEWRQLTIADKKIPRRAGITALGAGGVNAHMIVEEYQE AVTSMPKLKAAVSPIVFVLSAKTQPVFNDYLNIWVDYLNNNTDINLNNLAYSLQCGREAMKYRFACVIDS HKVLLQSLHAAVKNSDSPNSYRGIVNQLDHSFINVDENKQVEQGLIENDLTQLAKLWVAGRDIEWQHLYK DSSIVHLTQLPTYPFSQKVYWENYDRKKMMDHIVNEGCTMVSDIDDELIESTQSLNTDATSFIPLDLNFI EEKNETDIYHIESYDDSYDDLKDNDSNMSEMSDDIRLITDEVDGIEHDDDIAISQRIRTILDKLLYLDDD DEIDEITNFVDIGITSMNLVEFISQLNREFSLDMKETVLFDYPNINTLSNMIENELEAVEV BryX ? ? GNAT ? MT ACP KS9 DH ACP (KS10)GNAT KR KS11 MLEVINRYCHGYVFVPVVLALEEKGFFDLFTRNRYLTFEKIKTELNANSGHLQVALRMLQSVSWISCDDK GYVLTDAADERNKISSDFIELFNFSMSRYLENMERHGLKKWIDQSGDNWGISNPVLTDFLDGVLIIPLLL ELKENGYFDALKNVNSLNKKLFLGDIEQSVRNEIITLFKQKNWLQEDEETFYFTKSGQFITQRIFITAII ASYKPMLSRITELMFGNARSIFKKGLHGEESHVDRTLNVIGSGFQHQKYFADIEALVIQLFNDTFYDQQP KYIADMGCGDGTLLKNIYNIIKEKSARGNVLNHYPVVLIGIDYNEAALQETNNTLAGVDTRHYVLKGDIG DPEGMISDLYDLGIKDPENILHVRSFLDHDRPYIAPTEVMNIEARSKIFDQGVYVDSEGQAISPVVMIQS LVEHFKRWSCVKTKHGLLILEVHSLNPEVVNQYLDESESLHFDAYHGFSSQYLVSAEDFLICAAEAGLFS KPDVSQNYPRNLPFTRITLNFFEKKPYQIRHPNENDLSALMDLEKICRPNNQCLCIDDLRQRIDEYPKGQ CVLELNNTIVAVIYSQKCINRVLGTAAGVWQHNARGQCIHYLYINVLPKIKKEYAIQLLQFISIYHGVHN DVEDVIGIDECYQCLNEKTIQAGSFMESESVDVLYSRVEKHIAKYPIDIGVNALDAEQEMGLFGAKWLLS IFQSQGVMKKSGEYYQKDQLRLMLNIIPKYYRLFECLLLIFEKRKLISIQKNTVQTLSNIDEFALNDPLV EFASFKRTFSSQYASLMPFLRLMASCLSRYLEILTGKIQAHDIIFPEGGMNLFEGIFKGYQLSDYFNHIL AELIYERANALSVGNMNKTIRILEIGAGTGGATEFVLNRASPLSNVIEFYYTDISSSFLRYGESRFSDKY PWLQYKVLDIESNLDAQGFYPDSFDIVYASNVLHDTKYIQYTLSQVSHMLTQNGLLMLNEFTRMKDLLLF TGGLLDGLWLYEDPTNRLDNVCLLNVDQWRSILFKSGFKNVKDFVLPFEKLNIEQSQSIIVSEWINEDLS SNVENVVKNNHCLEIQNHSDPITVENKIVTIKDNTSLHDSIEKIFYKILGDKRKLGFSPKRPLMELGLDS IELLELRSLLGKHFSIKLEPTFLFQYETMAAVIEYFRSLSVSSDMIQDKPDIIDKVPITEEIMTGGTSRV RTGQSNQNEPIAIIGMSCLFPGEVTTVDEFWELLIQERHAIQPLPKGRWQWPEGVDPSGAQLGIDQGGFL DGIDTFDADFFRISRKEAELMDPQQRKLLELSWQVIEHAGYKPSVFSGQEIGIYVGACHGNYRELLTKSD QSLKTTEGYLMTGSMLSFLPNRISYFYNFKGPSVAIDTACSSVLVAIDQAVYAIQSGRCDQALVGGINLM STPSDTVSYYQAGMLSKSGKCKTFDATADGYVRGEGGAMLFLKSLSQAEYDKDCIYGVIKGVGVNHGGQA SSLTVPKPDSQAALLKSVYLKANVHPDTISYIETHGTATPLGDSVEVNALKQAFGSFYPDMAQKKLNSRY CGLGSVKTNIGHLEAASGIAGIIKILLSMRYRRIPASLNYTQLNPNIELSDSPFYIVNKSRDWPVLQDSR GGEIPRRAGVNVYGGGGVNAHVVLEEYVTSPDMNNVNIPNATLPDQKKTELIILSAMNEETLKHIAKNLK SYLSKTARLEKHDLADIAYTLQVGREAMKARAIFLVDNNSELIEKLEDFVVGKKVIKNHYAGYVSAENEL IALFDSAEDKQKTIKTWMLDGQFEKLARLWVKGLPVDWSLLHDNPRPNRIALPCYPFAKETYWIPAHAET

IIPHRDNANVVNKINPLLHTNISDFTQQCFVSTFTGYEVFFKDHVIQGKRILPGVAYLEMARAAIEQSVG PLYKYKSYIQLQHIAWATPFFIQKKTDVYIHLFINSSDPSERVGNNLIQYEIYTKALDNEHNENLSAATR VIHHHGVALLRNGDDDTEDVNITELTAEIMLSERDNEYHYLDTKKCYALFKNMCIDYSSCDKGIQDIYAN NHQVLARLVIPASVLHTQDQFIMPPSLMDSALQAHIGLESHAWTSDSVNLSLYVPFAVDTIDVIAACTAN MWVWIRYCLPQEQNINKPFKKLNMDLCDDKGKVCIKIRGLSLKRITGYYPHWQEQTLPGQRQRQIEKEIA VSSTHLEGDQLPSKVSSVNETELEERVFQYFKTLISSTLKRPRHRIQLDEALENYGIDSLLSIEMIIELE KVFGSLPKTLFFEYQTIRELGHYFFQTYTEQWCELFRMDNEPNIIDDRRTIEETKTSLTKASTGNLSKHI TQRNPYQSRFIAPPVGVNTQQSASVSTVLDVAIIGLSGRYPQAENMEKYWQNLCQGKDCITEIPKARWDW RDYYTGDPDHPGRHHSKWGGFIEDIEQFDALFFNISPREAERIDPQERLFLETSWTALEDAGYCRDSLDK SPLPRQVGVYVGVMYSEYQLLGFEQNLQGNPISSSISHASIANRVSYVLNVSGPSMAVDTMCSSSLTALH LACQDLTLGHTDMGIAGGVNISIHPDKYQLISDKRLVSSSAHCKSFGNGGDGYIPSEGVGAIILKRLADA ERDGDHIYGVIKGSAINHGGKTNGYSVPNPDKQQRVISEALQRAQIAPHQVSYVEAHGAGSRLGDPIEIT ALSKAFNNVSAQFNVKSAANQSCFIGSVKSNIGNCESAAGTASISKVLLQMKHGQIVPSLHSKELNPNID FSATPFVVNQELRDWQRPLIDGKTVPRVAGVFSFGAGGSNAYVVIEEYIAKIPTNNTRESINHRSIIPLS ARTAEQLRQIASRLLAFIEKNKQDSVVTPLIDIAYTLQVGREAMDERLGFIVSSTDELVEELRRYLPTHD DMEELYRGQVNRYEDTFLTMAADEDLSEAIHHWIKKRKLSKLMQYWIKGLVINWDKLYEGLPKDDSPRRI SLPTYPFARQYCWIVKDRSTHTHCDVMTSTKAISSKQLPLGKNKEILKNNDSFVGQDDVAETTLMVDMIR HSLRDTLADELYVNAEQLKDDMPFVDMGLDSIVGVTWIRKLSQKYHVSIDATKVYQYSSLRKMANYVLAE INRLGTAHLFSKQGMTSSPQQKYDISQQEAHTFTSSPSVSYIKPSLECVHQSSSIKKVAIDSDKRNHNGR EDGYRIMSATQNDITELLQLENVCLPQHLVCTRSMLVARIKLYPEGQILIKKQKKIIAALCSQRLDRKTL LYHAKCHQLLSLHHKNGAVLHIVSINILPEFRGQELERKLLNALLYQKHFMDGIQYLTRIISCENYHDHT IELKDYLQQVAHNDWYKEPVLNFHHSHGGRVVGLIRNYQVLNRNSQGYGVLIEHTINSFSQSIRESFPAT KDFEKTSQYQPLSKRIRSLMRLYPEIVPLSIEGSGCNTFWIHGGSGEVGVYMDIAKHLQTSDFKMIGIQA RGFLMPNAPPLNNLVEMARYYSKMIVSVDPIGPYHIIGFSMGGAITYEVGRQLQLAGKTVNTLVMVEPPV CNDNQYADLFNVSKCENFLANANFLLLVTLYLDRDFSEKLNTGEINWDTYMIVEEDVLDIADDELVSYLV QLCLKKGIKQSAEALEFKLRSISDIHLANLQAIQDYRPKTLPYPDKTSIVLMRTESAKATSDAIWNPEYL KNIQRVWGSMMPFFQYWDSLIPNLKTIIIGGNNHVDMLNDKKSLNKFLQQLRQLYNKHKSNNESCDYFHE KNNGILIDRSHTESNIAIIGISGCFPDAKNVNEFWENLKNARHSVKEIPYNRSWDIDNYFDTSSQTHAQE YVKQGAFLENIDLFDPLFFNISPVEAELMDPTERFFLQESWKAIEDAGYDASNLSGKRWGVFACAKGDYH AIIHKQDKTRIMTTDSMPPARFAYLLNLLGPAVHVDTACSSSLAAIAYACDSLILRNCDVAIAGGGNINS TPSLLISSSQLGLLSKDGRCYAFDQRANGTVLGEAVASIILKPLQQAIDDGDQVYGLIKGWGMNQDGKTN GITAPSVKSQIQLETDVYQKFMINPEHITMVEAHGTGTKLGDPIEVQALTEAFQKYTQKTGYCALGSLKS NIGHTFSAAGVASVIKVLLSFKHSQIPPSINFKTINSHIPIDKTPFFVNSHLNPWPYRADQSRCAAVSAF GATGTNVHLVIEEYISKSSTLNTSRLIDDKPLPVIIPLSAKDPDRLKEVAQRLLEFIREHSTAEVGGEKG LHTDNVDATELQNKLDLQSVAYTLQVGRQAMTERLGFIVSSFKELEKKLDEFMYDKKNIKGMYTGKIKDN EETITLFSRDKEMIEVVKLWMRKKKFSKILNLWVKGLTLDWKQLYGKEHPARISLPCYPFAKERYWLDTD KLVDGSYLNPRQEGINTDSDKFDEKLYESLLDNLFSKTMTPDEAIKLMEEEVS BryD (DH) KR ACP KS12 KR ACP (KS13) ACP C MKKLIKLIYEKVFENKLSKSEALSLISGLKASNTTILHPLIHENTSSFFEKKFSSTFSGREFFFRIDANL KKSVLSPVTYLEMVYAAATKAMAGEKFSAQFKKIEWQYPAIVHEESITVHIRFFKDPNTWLDTSEEKFLC YQIYTISNNQETSDIVHNRGVIDYDHKNSELSPLDIFSLQKHISEYFLDPKEDSDFFEKSDKSNEPYYQS IELLHINFQKEALIKLSFDHVSDTYNHQESLVLHPDILELALQSCSFLCLDMADTESEFFGELQPVSVDA LSIMSRCQDSMWVWLRLNSFHEGRLIVDIDLCDEYGYVCVQLKGLVLEANEHCKQNNIIPPTETSLDNIE PYEVMCFEEEWKAQLLKENTLNTQKNTSHTVICLLSEPDNQAALKSAMHSISPQTQLVFMSQSDTQKNSS ECFFVNPYDGITYQEALKNIIQVHGVSEIYNVLYLWAWEDSHWIESSIPVVHLLQSIKASEIKVQRILLA ANYKTDLQRCYIESWLGFERSLDLVLPSIHLKVFLLQDISNTKKSIAEQINDYTKTLWSELKTTTPGSVL YKKDQRYQLSIQSVTLKDADSKSILRGTVLITGGCGGLGLLFAQYLAKTQGTDFILVGRSPLNEEKQQAI QTLENLGSRVYYLQADVCDKTALQHGLVLAKEHCRNALCAVIHAAGIIDNDDIVTKNIDNFQKVLLPKIE GIRILDEVLADEVLDIVCYFSSASAILGDSGQCDYAVANRFLMSYGNYRNTLVSEGKRSGKTIVFNWPGW HVDSMLAGDWDADNSQQQLDFYLKSSGQRLLEAAEGCELFEKIIDQSKKQFLVIPGQQSRVKRFLSRIGK YGDIHSNTKNIPGVLDLLEGVDKCSSWRPEMKGFTIFQCIEWDLKSLIVQQLKLPIHKVETESNLADFGF DSISLTAYASTLSNHYNIDVTPSIFFTYPTIARLCDYFENDYKAIMENFYRQESIVNNTKKTATTPIQSS QAKSQRAIQPDFLFKQKEDSINKESINNEPIAIIGMSGRFPEARNIHEMWNILSEQRHVVQEISIERFPE YQEYLTQVNGGHWWSGCIPGAYEFDPLFFEISPLEAETMDPRQRLLLQESWNALEDAGYGDCQLKKYKTG MFVGVEEGDYSLLAKMSNVTSIHTGILAARLAYFLNFNGPTMAINTACSSGLVALHQACVSLRQRECGTA IAAGVSIHCTLGPQVGMEQAGILSPDGKCFTFDKRANGMVPGEAVVAVVLKPLSQAIADGDPVYASIRGS GLNYDGKTNGITAPSGTAQTALLKQVYEQAQVDVKHIDYIVAHGTGTQLGDPIEVNALYDAFKDNTDKQN YCALTSTKTNFGHTFAASGLVSLVSLVQALEHEQIPASLHCEEENDYIHWSSSPFYVNKQTRPWPKQGNK ARMGALSAFGISGTNTHVIVEDSIREAEGGADPLPYYLIVLSAKTESALQARIHRLQDALQEDRLAKVDM SALAYTLQTGRHHFQYRSALVVQDREDAIYSLGQLRDKVQRLNGLTGHAPRGFKGQIVMVRYIDLLLDKS STVQEVASDYQEVLLGLADYYCQGYEIDWWRLYEGRHPPRLHLPTYPFAREEYRPTPRVEKPGVTASIPL SSEAVSETSVTPDAEIVLSYPHWQPQTLAGAKEGAIACDRWVLWYGLDIADEWLAEIKGLEFIRLSSASS GVEKRYGDIALAVFEWLKHLLQESPNSQILIQVLIPNEEEYRVYAGISGLLKTAHLENPAVKGQVIEVEP

GLHRQALQAMIEENAMTPDIRRIRYESGDRWVQQWAVEGHEPCGQEVLWQPGGVYLISGGVGGIGLHIAH AMAVDVSDVVFILTGRSRLKDLTVAQREKLTELASLCARLEYHSVDVGSRDELKHLLDTIVTSYGQLDGI VHSAGITRDNFILKKSVEEFDSVLHPKVSGAVYLDELTRDMDIDFFILFSSISSVLGNVGQSDYAVANSF MDEFALYRHRLVERQARRGRTVSINWPYWKEGGMRLEASTEALMQQNDVMVALETQQGVEALRRALQTGH GQLMVTMGEPVWMKEPRRPTLPESTAVEMDSRPLSELDDKCLRQKVQRQFKGLLAEVIKLPLERMDTQAP LERYGIDSLIVIQVNQALAAIFDALPKTLLFEYQTIDAVVAYLVEQHRQACRVWTGLTATGQAQREGVIS STSSAGVEPVTPRQKEGHPIQKDIKCREHPVTDEPIAIIGLSGHYPQANSLDAYWENLKAGKDCIREIPD DRWSLDGFFHEDVEEAIAQGKSYSKWGGFLEGFADFDPLFFNLSPREVMTIDPQERLFLQSAWEAVEDAG YTRAQLASQFNKRVGVFAGITKTGFNLYAGDLNSQAELFYPYTSFSMLVNRVSYFLDLQGPSIPVDTMCS SSLTAIHEACEHLHRQRCELAIAGGVNLYLHPSSYIHLCAGHILSKNNRCSAFGQGGDGFVPGEGVGCVL LKPLSCAERDGDNIYAVILGSHTNHSGRAGGMGPNLNAQSDLIIENLRQCGIAPDTIGYVESASNGSHLG DSIELRALDKAFSQHTKKRDFCAIGSVKPNIGHLESASGMSQLTKVLLQLRHKQLVPSIHAQPLNSNIDF EDTAFRLQKEVEEWKRLIVQVNGENKEIPRRAAINSFGAGGVNANLIIQEYEDNINRKPEEVYGPFIIVL SALNENQLKLVAHNLYTYLNNYEQLDTEYMANIAYTLQIGREEMPCRVAMVVDSYQGLIQYLRVYLKLDN NVDKKMFIPEIFYGDLTTKNYEMNSLISGEIGDIIFQKLFTDGDLEKIALYWTQGGEVPWNLIHEGKNRK RISLPTYPFEKRWYWISEQYGDVACQEDKVNINVNSEKSISQNEITQQSIQKILIDFLVDITNFSRQDIN PGRMPGDYGVDSLLGMRFLNRINSTFNIEADALLLTEGTINSISHKVHSFIVDKKNYPMLPNFGLENDSN KENKGWVKPSFIEFIKFEINPEYIESSTKNKDYAILENLINNGVGVWRENNHLCFEFFYETHTNETIKKI VFSPEILFNSLDKGKRYFPSSCQQKNSLYQTEVEKFPYNLIQGFRVEMPVNIEILNKAFNHLVNTYSIFR TKAMLINKQWIQVIHDGLSVRCEEIIYEGLSAEKDFTQQLIVFQKEQGKKLFDIDNLPLLKIYFIHNGKD LAAIFVHAHHFCADGFTFFSFQKEFHDTYESIMNGGKQSFDKVMAEYGHFALCEYNPKNKELTKNWLDKI RDKNFSLKFKDKKDYVGQLSSGEKIIELEVSVNMLEKLRLFNDANNTTLTQLLCCAVAILLYRLSRLPVP LQMVNSRRDKIEFEIMMGDFASTLPMILELQKHFSIRDVLFSYEKEMLDIQRYKWLDISELRKNISKNGR NPYDFNLFGNILIDSNDMNSLFKETNCSKEMVPVSMEINNILTDMAIFLMKKDDYSSLMFIYDAELFSSK TMRLFSENIRIIIDIILKNTDKPIEEIEILIELKNRLYFEKNLVRL BryA DH KR FkbH ACP KS14 KR ACP KS15 KR ACP KS16 OMT ACP MLYDQDKTYSVFFTKEEVDWFSSVSMDHNPLHIDEAYSRKSAYGQPVVFGVLGVLKCIRQYRKKRLFYKL DIEFRNPIFIDTEYSLSIIYESDKTIFKLLDNEIILIHIVAFSAKITLTDGNNKSHKYNQIELKTTPLDY KDNELIASKGVEGVYRIEDKILYSQKPEVLPDNISFNQLQILMACSYIVGMELPGKRAFFSKLLIEFTDI LADKEIPSYQAKINNFNQPFRFLEFDTVFFIKEKKVANAKIGTFVRQNLNSISLYDIQLKLNSHTISLRG KVALLTGASRGLGAAFARVLAVCGVHVFINYFKSKSEAELIQQEIKKFGGNATLLEADISNNQQCQKVRE IVLKKFQRLDILICNACEPPLSMRGHLSERYIEQNLELYKSPTKYFLDILNNHRGILIAISSIFIETKPK EFQHYIQLKRKVEKLIHISCEEFSNIAYSIVRPPKLLTDMNNTPMGAVDAIPPETIAIEVVNRIPRLISG KIDILNKFSESQYIIQNEKKINNNIFYTIAIVSSFSIEPILSSIKFWIEKISIPLKIEIAPYGQIFQELL NRESTFRNYKNNLNVIFFRLEDWVKDFKINSLDEFSISKGEECKKLVNDYIKALIEYNNSAACPILIIIC PSSITTLKHHQWHEILSESEKKLYYSLNDLYNVKIIKAENWHSIYNVDNIFSPKTERYGHIPYQTEYYHI LGTILVRQYFALTHKLYKAIVVDCDNTLWDGVCGEDASEDIQISDVFSKFQNFLIEQTKKGFIICLNSKN NESDVWNVFKNNNNMQLKKNHIVYAQINWDAKSANLKKLSELLSIGLDSMIFIDDNPVECAEVKANFPEV FTLQFLSDKKSVEKLLYHTWIFDCYHIGIEDKNRTRLYQENKQRKVLEKNSFNFFEFIQNLNLKISFKNI SSIHLPRVSQLTYRTNQFNFTTKRRSIQEISKMVKNQAYECLTIDVCDRFGDYGLVGVIIYKCTKTVLKV DTLLLSCRVLGRGVEYKMLNKLGDIAAEYGLKQVSIQFIISAKNSPAKKFLEKIKKKVEINKNGEKIYNF HKDYLKNLYFDVRKINKKENQENLEWHNINYSDKSNIERKILDIASISYDMKSIDKAINKEHSSLKDNIE KNLTTSTRKYDNNDLKKIIINVFAKVLARRIDENDLNSNLENYGLDSYAIINIVVELSKTFENVHYTILF EHRTINNIIDYLTTNKEIVSETPNIPISNNDKYYLQFLQASKRANIDISNPEEIQNYIIELFNRELNLKG NPLDLEKDLELYSLDSKTITNITHQLCEQFTGLSSSILFEHRTVSSIVNFLLSEYTDYKPVVKEENIFNK SEMVVKEDENSDIAIIGVHGYYPKFCDTEAFWQYLKQGLDCIDEIPESRWDLKHFYHSLSDEVKNNYCQW GGFFDHVDQFDAAFFNISPREAEMMDPQQRLFLQVAWGVIEDAGYTCETIPRDTGVFVGVLSNDYNIYTS NAALQLNTDYRLADYYQIPNRVSYHLNLQGPSLAIDTACSSSGTAVHLACESLKNKTSSTAVVGGVNLIL HPGRLIQYSNMQMLSKEPVLGAFSNETNGTLLGEGVGALLLKPLQQAINDKDPIYALIKATNINTSGKTN GFTVPDPNVHASLIEKAISKSNIDPRAISYVEAHGTGTPLGDPIEIRGLSMAFDRLTQSHDYQYCAIGSI KSNIGHLESNAAIAGITKVLLQMKYKMLAPSLHAINLNSKINFEKTPFHIQHELSEWKRPTLVQQGVKKE YPRIAGVSSFGAGGSNVHIILEEYISEPMQKNPVVDSAGEPLAMVVICLSAKTECSLREYACELLKCIQN NFSNKEELIRDFYPTENISCQLNLLNLAYTLQIGRQALDQRLGFLVKSVAELEEKLASFLHNQDFDSTMY QNKIGCYQDIGMEFDHHIDVGVAIDQYIHNRDYDKLLECWLNGLAVDWNKLYGDIKPYRINLPTYQFAKD RHWIPTTDIYSHKPVDDRQVSKNNFELMVFEECWEARSQLSTISSKTKNCVCFLSDVESQKSLVKTFMDF NPNINIIFVSRGDSYAKKSAQNYIVSSHHKNDYVSAFEEIKKSIGNVEVILYLWPIEDSNYIPDYTPIVN LLQASQFAQCRFKRCLLAAQLSHALDCCYVESWIGFERSLKLVINDAALITVFRESSEHEDTIKNWSKRL WQEMHAVDFKSVFYQKEKSFVCRIRQISLTAERVLLKNKGTYLITGGAGKLGLLFARKLANMQEINLVLV GRSPINNDIQDCCEKINSLGSKALYLQANVCDIDDLKRCREKVNQCFGKIRGVIHAAGIQHNQSIFEKDF FDFEKVLEPKIKGTLVINKVFNITEMDFICYFSSSSAILGDFGSCDYAIANRFQMAYTDYQHQSGCLGKA IVINWPQWKDGAMGFGEGGNTKMALKSSGQRLLESTEGFDMFMNFLGQKKYQHLLLAGKPDRVYDFLGIT SPLVNSSNNTIQTSIKEVNIKQLIEEDLQNYINQLLKIPKNQLDIKRNLADFGFDSIRLKEFAHFLTQHF TIEVTPLLFFEYPTLEKISTYFTEQYAEIVENIYRQEGSEDTMLDKKSSRVLAAPITHTVTTAHEPIAII

GMSGRFPEARNIHEMWNILSEQRHVVQEISIERFPEYQEYLTQVNGGHWWSGCIPGAYEFDPLFFEISPL EAEMMDPRQRLLLQESWNALEDAGYGQEDMSNKSIGMFVGAETGDYQGLASGSNITSKHNAMLAARLAYF LNLSGPVMSIDTTCSSALVALHQACVNLRQHECDTAIVAGVNLCFALETYQTLSHAGMLSPDGKCFTFDK RANGMVPGEAVVAVVLKPLSQAIADGDPVYASIRGSGLNYDGKTNGITAPSGTAQTALLKQVYEQAQVDV KHIDYIVAHGTGTQLGDPIEVNALYDAFKDNTDKQNYCALTSTKTNFGHTFAASGLVSLVSLVQALEHEQ IPASLHCEEENDYIHWSSSPFYVNKQTRPWPKQGNKARMGALSAFGISGTNTHVIVEDSIREAEGGADPL PYYLIVLSAKTESALQARIHRLQDALQEDRLAKVDMSALAYTLQTGRHHFQYRSALVVQDREDAIYSLGQ LRDKVQRLNGLTGHAPRGFKGQIVMVRYIDLLLDKSSTVQEVASDYQEVLLGLADYYCQGYEIDWWRLYE GRHPPRLHLPTYPFAREEYRPTPRVEKPGVTASIPLSSEAVSETSVTPDAEIVLSYPHWQPQTLAGAKEG AIACDRWVLWYGLDIADEWLAEIKGVEFIRLSSASSGVEKRYGDIALAVFEWLKHLLQESPNSQILIQVL IPNEEEYRVYAGISGLLKTAHLENPAVKGQVIEVEPGLHRQALQAMIEENAMTPDIRRIRYESGDRWVQQ WAVEGHEPCGQEVLWQPGGVYLISGGVGGIGLHIAHAMAVDVSDVVFILTGRSRLKDLTVAQREKLTELA SLCARLEYHSVDVGSRDELKHLLDTIVTSYGQLDGIVHSAGITRDNFILKKSVEEFDSVLHPKVSGAVYL DELTRDMDIDFFILFSSISSVLGNVGQSDYAVANSFMDEFALYRHRLVERQARRGRTVSINWPYWKEGGM RLEASTEALMQQNDVMVALETQQGVEALRRALQTGHGQLMVTMGEPVWMKEPRRPTLPESTAVEMDSRPL SELDDKCLRQKVQRQFKGLLAEVIKLPLERMDTQAPLERYGIDSLIVIQVNQALAAIFDALPKTLLFEYQ TIDAVVAYLVEQHRQACRVWTGLTATGQAQREGVISSTSSAGVEPVTPRQKEGHPIQKDIKCREHPVTDE PIAIIGLSGHYPQANSLDAYWENLKAGKDCIREIPDDRWSLDGFFHEDVEEAIAQGKSYSKWGGFLEGFA DFDPLFFNLSPREVMTIDPQERLFLQSAWEAVEDAGYTRAQLASQFNKRVGVFAGITKTGFDFYGIQSDQ LFSAYTSFSSVANRVSYFLGLQGPSLSIDTMCSSSLTAIHEACEHLHRQRCELAIAGGVNLYLHPSTYIR LCTLRMLSKEGLCKSFGYGGNGFVPGEGVGAVLLKPLSRAIQDQDSIYAIIRGSCVNHGGKTNGYTVPNP HSQGDLIREALDKAQVNARMVSYIEAHGTGTELGDPIEVRGLTQAFQQDTDDVGFCVLGSVKSNIGHLEA AAGIAGLSKVILQMKYEKIVASLHAERLNANINFEQTPFVVQQSLNEWERPNLHVNGKIKEYPRTAGISS FGAGGTNAHIIIQEYIPEVSQTRQSEVRNKPAHPVAILLSAHTSAQLLKMAEALLLFIRTIVNNMDSSYS AGDEMTHLVNVAYTLQVGREAMQERLGFVVNSLSDIEVKLQKFIDKENDIEDFYRDQIKTKKEISALFNS DEDLQEVIKQWMRQKKLSRLLSLWVKGVHCDWNFLYQHMRTKPYRLHLPTYPFAYNRYWIDDNNKNQSTV VEKTNTIIKERKEQVRLEPLDFMERKKLNVHEKKPFHCSLSTQSEAWSGANTQTSSGKQRRSYVQVLKQD DILRDLKSALPTAVEGMIPTLNRTGVMTESLSSYSEAFANYAGMCGGEVLDLGCAYGIATIAALERGAQV LAVDMEAQHLEILSDRIRDEVKSRLSTQVGKLLDLHFDQERFAAIHASRVLHFLNPQDFQQALQKMYGWL KPGGKLFIVTDTPYMGYWASKAGVYETRKAAGDLWPGYIDNVGSHFNTKEIEGAPTLINPMDPEILHREC KKFGFHVEETVFFAGEAFALNNSLEKSGREHVGIIALKPELEDSDRLEKSLLPVRKTETENKEISLLQIQ TMLRESLEFELDIEPGMLDELKPFTDLGLDSINGVTWIRKINSHYGLSMTATKVYDYPNIIELAEFLRKQ IISNDEKQHQPSISTIFPTSLDELLKKIQEGTLGIEEADQLIDELPDYHLDMELHELL Burkholderia thailandensis polyketide (thailandamide) BTH_II1674 KS1 KR ACP KS2 DH KR ACP KS3 DH KR MT ACP KS4 ACP MGIEQLNTTRAQHDDIAVIGIACRFPGASDYRQFWDNLCERRVSIGEIPGERWDWRAYWGDPQQDANACN SRWGGFVDEVGAFDLGFFGMSAREVDKMDPQQRLALELAWHCFEDAGLRPSAVAKRDVGVFVGIANLDYK EIVEAHASEIDAYYASGVAASVASNRLSYWFDLRGPSVTVDTACSGSLYALHLAREALRRGECEMALAGG VSLLLTPRRYLGFARARMLSPTGAIRAFDDAADGMVRGEGGGLVLLKPLSRALDDGDRIFGVLAGSAVNH SGRTYSLTYPDADAQARVIRAAFDAAGVSPAQVSYVEAHGTGTPKGDPIELEGLLRVFGAQPRDALAPRC AIGSVKANIGHLESAAGIAGVIKTLLALHHGMLPPMPHFAALNHRVDAARFAAAGLAVADALAPWEAGAS ADGASAARIAGVSAFGFAGTNAHVVLREAPAAARAAVAAGRADGAGVLCLSAKTDAALERVRAGFVEWLA RDGARHAFADICAALVSRREHFASRIAVAACDVDGALAALRARADTASSVYRAGRVALDDDGNLVDASGP HDEQADHDGSGEHGEHGERARAGADDLSRARRRASRYVRGASPDAWGPSDGPTPHVPLPDYPFERTVCWT GPRPSRAVAGPARGPAVDEAVDEAVDEAGAADGDVFVLEPRWHLAPAADARPAPARPEDAAVVVCVVADA AQRAAVERALARIATAPACMFVEPDATMGEPARAVDALVRTLDGIADRARADVSGVDTSGAAAPISVWYC ADLARDARAPIDVRAYDRLLTLLQALAKTRAPLRRVLLAGVSESLAADAWPALVTVLAPRRPALAVTPVL FDHGTPEALWVSALLQEARAAGGAAVRYAAGERSVAVLARAANAASENAARLAGGAPLRTGGCYLLTGGL GGLGRLFAVRLMRRYGARVVALGRSAHDAGVQASVAALCAEAGAGTLRYLQADVCDAAAMAAVLDDIGRH EGRLNGVIHAAGCEDRASLADKSLDDVHAVLAPKLAAATVLDRLTAGLPLDFVCLFSSLAGIVGDFGCGA YALGNRLLMSYAQRADGRVDAHGRRRRVVAIAWPLWRDGAMGFDDPVKRDRYLAASGQRMLDADEGFAWF ERLLASPSAAPVVLAGERARIVSWLGSIDGAPVADASPGAASSGAAAPNAASDASRDTERAEATDAAAPI VAAGAPAHAHASAPRERDAHGSARLPALRGIAARVLGADAALLDEQASFADLGFDSIGLMDFARAVGEAF GIDMSPAMLFSHVTLKRLAGHLATRLDDAPRAVAGARSGAAHASAGRACAAAGRADGARASRIDVRPPEA GAGERAADARPPLTAPEIAPEIAPESASGFASAPHPAPIPPAYEPIAIVGMSGRFPDARDIDAFWSLLMS GRGAARRVDPHDRFAAPRDEAAAWLAPVPGIDEFDPLFFDIAPAEAQRMDPRERLLLQHAWLALEDAGIG ARALADHALGMFVGAEAGEYGGLSREPRSIVSDHNGVLAARLSYFLDLTGPNLSVNTACSSGLVALHLAI RSLHARECGIALAAGVNLMLSAELHDKMARAGMLSQHGVCRALDRDADGFVPGEAVVVVALKRLADALAD GDAIHGVIRASGVNYDGRTNGMTAPSGLAQARLLTDAWRTAGIDPAELGYVVAHGTGTRLGDPVELNALG DALRASTGRRHFCAVTSNKPNVGHTLAASGLVSLVNLVEALRRAVIPPSAHWREGNEFVAWGDSPLRVNT VASAWPDGARRLGGASAFGMSGTNAHVIVEAAEPARARAPHAPRGGVLFVVSAKTGDALAQRLRDLADCL ASDAWSDGDLADVAHTLLHGRQHFEHRSAVFARGKADAIDALRAAADAVRNAPARRTGALRLLDDYAAHL SARYAAWRDAPARDVDEARRLLEAIGDAYREGATPSALVVAPAPGRTVRLPGYPFACERHWHPAPARAGG

ASAGANAREPGARERAEAAAAPHVVVLTLTGSEPYLRDHLIDGQRVLPGAAHLDMARAAFERVRAAGGRA ARFVALRDVVWRAPLVAGDAGAEVHVELTPSGTAFAYRILSRPADRAAAVGAALTLHSEGVVDELNEPAP EPLDLDGWRAACAGERVDGAALHARFASLGIGYGPSHRGVAHVRLGEHAALARLDLGALADADFDGFGLH PGIVDSAFQASAALSAPREDAAVPFMLRALHVYSRAARTMWAAIRVAAPAGGGAGGVDTRPIDIDLVHDD GAICASLRGWVSARWRKLAGAPPAARATAALRGWRWRAAEPDPRAAEAATRVVLLAPDFGALAAELAAHD AVRCEMLDDVSSHALPDAFAARATQAFAAVRRELAAKPGRPVLFQAVCREADSATAWGLAGLFKTAADEN PLASGHVVLVSESFDRARLAAALLAERAWTGHLRYGGAGREAFAIDADEDDRDGREPAGGPPLRDDGVYA ISGGAGGIGRAIARDIVARTRAARVYLLGRSAHAPSDLFATADERARIRYCRVDVADREQVHAWIAGLKR DGEALRGVVHAAGVVDDAFVVAKEPSRVHAVLRPKVAGAVWLDEATRDAPLDFFVAFSSLASAFGNAGQA DYAMANAFVDGYMTERRARVAGGVSRGASLSIQWPLWADAGMRMPAAIASRLAAATGLAPLPSAEGIAAW RAALARDDANVAVLYGERAAIAAWLATSDAMPPRARAARPMPAARVDLHALRALAASLIGVDAHDINVDA DIDEYGLDAVALAHLAREIGERAGRADVGLGFVRGERTLRAIARALDASAPGGDAEVDIGADADADADNA PDAEACVECAGIDARATPPDAGAPQRGAHAAAAEGSARDEAARSIAPLAGAGSPDGASALRARVGARLSA LLADVLKVPVARLEPDAPFERYGIDSLTVVALNESLGRHVDALPKTLFFEYRTLAELTDYFVRRHAGAAW FAPDARAEHGAAGALATLGAATRATQTEQAEQSRVAPLAPPRRVFAAATAATRSRAASAPPAATADAIAV IGLAGRYPQARDLDAFWRNLRDGRDCITEIPAERWNHGDFFDPQKGVAGKTYSKWGGFIEGVDEFDAAFF NIAPRDAERMDPQERLFLQASYQAIEDAGYARASLGAGRVGVFAGVMYSEYQLYGIEESAAGRPAALSGS AASIANRVSYHLDLHGPSMAVDTMCSSSLTALHLACRSLQRGECELALAGGVNVSVHPNKYLMLADNRFV SSAGRCESFGAGGDGYVPAEGVGVAVLKPLRAAIADGDAIHGVICATALNHGGKNNGYTVPNPAWQAAVI EAALGEAGVAPGDVSYVEAHGTGTTLGDPIEIAGLARAFGEPGARRGAPCAIGSVKSNIGHAESAAGIAG LTKVLLQMRHRMLVPSLHADTLNPNIAFETTPFCVQRALERWERPGDGERVAGVSSFGAGGANAHVIVRE YRSDDERDGRDEPASTAPARARPAWIVLSARNEDGLRARAAQLRELAAGCEGDADLHAIAYTLQTGRDAM DERLAFEATSIADLIASLDAFARGEPGKKQLRGNGRARRGDAPPAGVADARLARGEHRAALDDWVRGASI DWRRAYGPGAPFGPAPRRMHLPVYPFARTRHWLPAPLDARRRAARAGGGLHPMLDANRSEFGRQRFVVEF DGREPWLADHRVDGRRVLPGVAYLEMARAALAASAPDMHADGGATLEDVRWLRPCIVPDGGATLEIALER DGDGIAFSISQTSAHAQPALCCTGRSPSRAARGGGERIDVDAMRDAFRAAPAFDADACYRAFARRGVQYG PSHRTIERVWADGDRALARLRSARPADPRLVMWPGLLDGALQSLIGLHGLDGDLLAAPYRLARLDVHGAC GPAMWALARRAGDGALDLVLCDDAGEACVTMRGFASRAAASWRTAAQAAGAPHEAVAGGDARAAFGPAAE SPSAATSTSAATSPAISTSAATPAAADGDDWLLLPRWLACDLDPERDAGARAVAPRSVLAIADDACVHDL SAAAFGGASVRRMPASDAADAARLAAILGDAPRLDALVFVAPGAHARSAQALIDAQESGAIALFRIVKAL LAHGYRDDALTLAIVTEQAVALYPGEPIDPAHAALHGMAGVLGRDLPRWRVLCADVERARAYAGAALVAQ AGPAGEGPRINRLGRWHRRALARVDAPAARESAFRRGGVYVIVGGAGGLGRVLTEHLIRRADARVVWVGR RAADGRIAADCASFESIGAPPLYLQADASDAGAMGAVRDAVKARYGAIHGVVHSALALRDATLATMTEAD FRRVLAAKLDTSVRLAEAFADEPLDFMLFFSSFAAFSFPQGQANYAAGCAFQDAFAQHLAARAPFAVKTV NWGFWGHAGVVATPAHRDRMARLGIGSIEPDAAMRSLECLLACDVGQLALINVRRDDAIAPLMTPRRVAL HAPGAGPRALDSVARVRPDAERTAAARLHGGLQRDEWRDVLLSLLDATFDALGARRAAEAGGDALRAALG IAPRHARWFAASLDWLRALREGAHAAAAMSADDAWRAWARLGAACDGDAGRSAQYALVDATLRHLADIVT GRRKATEIMFPKGSMALVENVYRHHPVADYFNLAVAEIVAARAADVVRERGVRILEVGAGTGGTTARVLA VLRERGVRVDDYRFTDVSPGFLDHAAARFGAGAPFMSYGLFDVMRAPAAQGIAPHGFDIVVATNVLHATA DVRASLRHCRDALRAGGLLVVNEISDKSLFTHLTFGLLDGWWAYEDAALRIDGSPALDAHHWAFALRSEG YADVAFPWADAHDLGQQIVLADAGDVVDAADAQAMRAREAEPWAWATGAESESVLEAVSETETALTPAPT QSPAAPSDATRTAALLRSLLGEALKVEPVSIEGDGAFGDYGLDSIIGMGFVDAINRALDLSLDVTAVFEH NTVDALAAYVGSQLAARAPAAAGARDVEPASSLASSSASDFVSARLPAVDAAASSAFDAAPRARTGADAP DTSLASSASSISSARASSPASPARDAASFDVAIVGASCRFPGADGLDALWRCIVDERSCVRDVGAKWLRT RDPADAGADYRAAVLDGIDRFDAARFGISPREARRMDPQQRLLLTEAWRALQDAGDAARAAAHRTGVFVA AGANEYGAGLDAADNPFSMTSMAPALMPNRISYALDLRGPSEMTDTACSSSLVALHRAVRSLRDGECDQA VVAAVNLLLSAEKFEGFAELGFLSPSGRTRSFDAAGDGFVRGEGAAALVLKPLAAARRDGDFVYACIKGT AVHHGGRGAALTAPNAAGIREAMSAAYRNAGIDARTVSYLEAHGVGSPVGDAIELNAIRDAYAALSGEPA PAAPAASCRIGSVKPVFGHVELASGLLAVCKVLMALRHGVLPGVPGFERPNPHANLAGSPLVVARAAAPW PAPRDDANGAAVPRRASVNSFGFGGVNAHVVLEEDVSSRHAPRVFAQPPLDGARHWECPREIAGAPAARP GRPAPDAPHARIEAVIRDALAQALGVAPDAFELAVPLGEYGADSMLDLHLATRIEETLGVQLSVRELFAH RTLGALRDHVAERIARDGGRRAAEAARAPDAAMASDVAEASVVSEATEASDASEASDASEASEASEASEA SKAPADLAALLERFRAGQMDLDDIVDLV BTH_II1673 C A PCP KS5 DH KR ACP KS6 ACP ACP MPRWRPTWLKRLSCPKQPRHPTHPKHPTHPKHPKHPKHPRHPKHPRISRRCSSASARGKWISTTSSTWFD GDHVNKKDILLAYREGLLDTGSAQRVLDALRERSASAPLSSVEQGIWATQRAAPGSTAYHVPVVLHVARA LDIDALRRACLDLALAFPILTSTIVERDGEPRRAAFSSAPAQLRHERVGALSDDALAARLADAKREPFDL RAGPLWRLFAFERGRADFVLMLVVHHLSYDGASTLPLVDTLLAMHDARAAGATPAIEPFAPAHDAYVADE ARWLASADAAATLDYWRRALDGAPPALELPLDRPRPAQQTFNGKVVQRALPEVLGERAAAFAAQGGLTRA ALFLAVFKLLLSRYAAQDDIVVGVPVSRRPLAARGAVGNFVNLLPLRSRVDARLTFAAFAAQVQGTLNAG RDHAAYPFPELVKRLNVPRDAALAPVFQALFAYQNFAGADAEAAFCARHRARFLQIEHQAGESEIGVEVF ERASASVVHLKFNPDLFDDASAARMLDHFVHLLDATLADPRRPLADYPLVTPAERERIVSRWNATAAPYP DDRCLHELVDEHARTRADARAVSDARDALGFGELKRRSDAIAAALVDAGAAPRALVGVCMTRSVDLLAAL

IGVMKAGAAYVPLDPRYPDARLRAIVDDAQLEHVLTDAESAPVAAPLCADGARVMLDAARCAAGGSRAPL PRATPDDLAYVIYTSGSTGKPKGVMVPHRAVVNLLCSMARAPGMAAGERMLALATYAFDMSVPELFLPLA VGGECMLAQADAARDPRVLMEAIAERRPTIMQITPTACAMLFEAGWRNAERVALLCGAEPLTETVRRRLA ETGTRAWNMYGPTETTVWSTMAPIAADRPITLGAPLANTRVYIVDGQDRLLPPGLYGEMVIAGDGVARGY LGRPELSAERFVRDPFVNAGRGANAYRTGDIARWRDDGSLEFAGRSDAQVKLRGFRIELGDIEAHLKRHP AIEDAVAVVNEAHGLKRLVGYVVVRGGAAAPSWSALRSWLLAALPAHMVPACYEALPAVPLTPNGKIDRR GLAARPLAAAAGAQAADGLEAGGLVGGLEGEVLALWRETLKVGDIGPTDGFFDAGGDSILAVALAARIEQ RFGVTFSATTLFKYACVRDIAGYIASAEARPRAGGANARAGVEAGAAVATPPGRPAGEAAGAQRDRAPRA ADERADAPPAAPSDAHASKAAAIDSRGGAAGGDGEPARAASHGDAPADGLAIIGIALRVPGAADARAFWR NLREGRSALERLDARRLMAHGVASALAGARQTVGVRATIADKHRFDAEFFGVSMRDAALMDPQARQLLQH AWLAFEDAGYVPADAPDTAVFVSASHSRYAAKQADGARAAAEAVLDDPADYVGWILEQGGTIPALISYKL GLTGPSLYVHTNCSSSLAALYAAWQTIRAGDAKQALVAAATLFADERLGYVHQPGLNFSSDGRIKTFDRN ADGMVPGEGVVAVLVKRVAEALADGDRIYAIVRDVALNNDGAAKAGFYAPSVRGQAQVIDALLRRTGVRA ADIVYVEAHGTGTQIGDPIEVAALTDAYRAHGAGTGHCGLGSVKTNVGHLDTAAGLVGLVKVALSLEQRM LPPSLNFDAPNPALDLASSPFYVVERATPIAPRAGRTFAAVSAFGVGGTNAHALVEAHRDARDAAIATGA TGAPDVPDAPDAPDAPDAQTVVPLSAKTPAQLTQRAAQLLDALRGDDARRPALADVAFTLQRGRQPMGSR AAFVVDSIDMLCEQLAAYVAAGGAHAPRGAARADATHAHAGDAHRLAERWVAGDDVDWRALSRGGRRIGL PGYPFGGDVYGGARDAHDPSRRLHPLLHRNVSTLSQVAFTSTFDGGEPFLRDHLLHGRRVLPGAAYLEMI HAAAERALAPAAGAGAGVALANVVWVRPVEVVDASVTVRLAFAPADDDGLVAFEIRSETAGGGGALHCRG HVQRIAEPAPGQIDLHALRERCAAPRLSAARCYETYARLGLDYGPSHRGVVDVRGEREHLLARIVLAGLP DADARPMHAGLVDSAFQATLAAVAETPDELERLDAAPVPFALGRLDVLAPCAPQMWASIRVRRIGGAHAD GGRTASDDALLAKIDIDLVDDAGNVCVRVRDLAARRFVREPARAPSRTLAVRARWRGARASGVPGASGGV PREVVLVGVDARAAEPIRAALGASGVACEVWPIPADADPAGQFAALAARVLERLQAAVRARPTSPRLLQL VSLDDAPWFAAALAAMLKTAALEQPCVLGQQIALPSRLSPARIAAALADCAAMPDARRLRFGANDADADA DGALEVETFAELDAWPEQAAPPWKAGGVYLVTGGGGRIARRLIDAIAAHAANATVVVASRTQPGAARADA RHATDASDTPHAPGVTVDRIALDVTDGARVRDAVRSIVSRHGRLDGVLHGAGVLDDDFILNKDARALHAV IAPKAQGAWHLDAATASLDLDCFVLFSSVAGALGNAGQVDYSGANAFMDAFAHWRRARVAAGERRGRTVS IGWPLWAEGGMRIDDASLAALERSLGMRPMPTPAAIGALYAALACGESHVVLFHGDPAPLRRAAWLAASA PTQDDPAAASIEPAASSTELPEMNVQATAPADAGARPRDDAPAAAVAHAAPDASDAPDARPADAAPADDA RLTEHALALLKRLLSTALHTPASRLDAHAPLERYGIDSIVVVSMNGELEKAFGSLSKTLFFEYRTLHELA CYFVAHHRERLARLLPAGHGARLAPAPAQPLAPRAPSAEPARDAARSLEPEQGQGQGQGQEPEPASQTAA ASESARAPAQASAHARRERAAPETRTQAPAQAHAPAQASAPDAARDAFDIAIVGLAGRYPGADSVDAFWA NLRDGRDCVTEVPAERWDHARYFHPDKAHPGTTYAKWGGFVDGVDRFDAAFFNMSPREAAIVDPQERLFL ETVYEAIEDAGYTPRTLAGGAGRDAAVGVYVGVMYQEYQLYGAQASALGEPCALPSSPSSIANRVSFFCD FDGPSIAVDTMCSSSLTAIHLACQSLRSGECAAAVAGGVNLTLHPNKYLLLSFGRFASSKGRCESFGAGG DGYVPAEGVGAVVLKPLARARADGDHVYGVIKGSALNHGGRTNGFTVPNPASQRRVILRALREAGVDPRR LGYVEAHGTGTSLGDPIEIDALSRAFAEFTQDKQFCPIGSVKSNIGHAESAAGVAALTKVLMQLKHDTLA PSLHADVLNPNIDFAATPFYVQRERADWPPAVDAGEAGGVARRRPRVCAVSSFGAGGSNAHLIVEEYVAS DGERAVRSASDQLVVLSARSPEQLRERARRLRARLLADAGGTPLDALAYTLQVGREAMAYRFATIVATRD ALAARLDALANDALFDGQALPGDADGFARRAERDETLVSLARDDAFRDAVGRWVAEGQLARLAQLWVRGV DLDWTLLHRSPPARISLPTYPFKRDRHWGVPNLAGLPGAAGVANVAGVAGAAGPAGVEHAASGAGAASVA SAAGAASAASTASTASRAGTPSPAVAASTGETVAAPASHDAFATAGAKPGVVLAPATAAGYVATPRPKPT VMLDTDAAAAARARPGAASSPSPSSPSPLPSSPPRMSSRQHASPAAAPDPRAALLDIEAFLAGSLAAALM ATTDEIDREQTFNALGVDSIVGVEWVRAINDRYGTALPATVIYDHPSVRAMARHVSSNATPGVAGVARGD ASAPQAAPSAFAAAASSASGAVSPAPFASAAPPEPPASPARADGALDAAGATSLDAIRAHLVDSLAQALY VEPAEIGVDQPFAELGLDSIVGVEWITAVNRRFGTALPAVAIYDHPSVVALARFVGTQLGARLPAAQAAR AGAFAGVEPGEPDARALPAAARAAAPPAHTDAAAHTDTDALLRAIERGELDAGDADAIWRRMQSRAARPE PLAQP BTH_II1667 KS7 KR ACP (KS8) MRSSKEIFEALRDGRLSREEAHAALRSARAAADAAGANGAADAADAGDAASGASAANGERAAHAAKTAES AAAADAMPIAIIGRSGRYPDAPDLAAYWRNLAAGRDSVRPIAPSRWDTDAWFDARRGEPGRIYCRALGAL DDIDCFDPLFFHISPAEAQYIDPQHRIVLEEAYRAFEDAGYTPQRLGGRACGVYLGIMSNEYAMMLARER APIVNATGNAFSIAAARIAYWLDLKGPALALDTACSSSLVAVHLACQALRAGEVEMALACGVSLYLTAES YVAMCGANMLSARGACRAFDNDADGFVPGEGAGAVLLKRLDAAERDGDRILATIAASGINQDGKTNGITA PSAASQSALVRDVYARFGIDATSVDYCEMHGTGTKLGDPIELRALADVYREAGAAAGACAIGSVKTNIGH TSAAAGVASLHKVMLALEHGALAPSLHFDAPNEHFDFAASPFRVVTHAQPWPRRADRPRRAAISSFGLSG TNAHVIVDEYRGRARGAASHASGAAHASGVPDASNVSGVRDALPASNAANAPRRPEVPEAPETPSARHPA TDALVVLSARDAERLRDYARRLLRHVSDTSPVSLPDLAYTLQTGRAAMPHRLAIAADAVDTLRDALSAFV DGRPHPALVAGAAQGGAGTGAAREALTHAHAWDALARAWVAGAEIDWPAAHGAALAERVRVNAPTYPFAR ERYWLPRPPADEAGARRRVALVRDWTSAPLGAPAVSGARPVATRILMVGRCAANRALADALAPMLPDAAL IDVCDDASFDRLPAAAGVVDLTGCAREPIDEMRWLALVQRVVASRPRALYAVTAGLETPARGAAGLAGAW QAGLYLALAAEYPSVASRVVDLPEGGEPSALAALVAAEYDGASADVHCRYRDGVRERAIVRPLDIDADVD APGRAPRASVLGPDDCVWITGGTRGLGLTCARHLVSRHGVRRLLLTGRTALPPRSEWDALGARDADFARR

AAGLRALEAMGARIEYSAVALDDARAVAAELARVRPTLGAVTALVHCAGAVDWSEPAFFAKSRESMRAVL QPKTAGLATVVDALAGAPVKRIVLFSSVAAAIPALGAGQADYATANAWLDYFARAYARALPVVSVQWPNW RGAGMGEVRSRAYAQSGLSALDDAQGLALFDWALERMPAPVVLPAFVRDGERPWLDWLGARTAHRAAFDA ESDAGPAAARASVVAAEGEAGRDRLSGGASGIASGAASVDGGGDGHRIGEAARDGDGEGEGNGEGNGEGE GEGAFVAAVRAWLASTFARELALPSGTLDPAKPFREYGVDSIMLTQLLRPLNRLADAPLDPSLLFEYGDV AQLADWLVAHRAELMRQALAAEGARAPADARPAGIAAPDPRALSPAAATHADAARVETTCAMRGTAATSA AIETPAPPASPAAPTVPATSATAATSATAATAATAATPAAPPSPMRDSQARPCDIAVVGLACRFPGAPSV DAYWALLRDGARGIGPAPRERFAQADRFCGGFLDAVGRFDPDHFGIAPGDARAMDPQALLLLELGVELFH HAGYRPEELRGGAVGVFLGGRSQHAPDAALLAHAHHPIVAVGQNYLAANLSRHFDLNGACALVDTACSSA LVAMHSAVLALAAGEIDAAVVGGVSLLSSDAGHRLFEQRGLLAPDGAFHLFDERANGTVLSEGAGLVMLK PLAAARAHGDTIYAVLKGLAVNNDGRTAGPSSPNFAAQQAVMRRALAQSGLRADDVRHVEANGSGSRVTD LLELKSIRAVYGGQSRDAAWCALGSVKPSIGHTLCAQGIAAFIKSVLMLHHRSVPPFLSGQQPMQHSPIE RSRLRFVRETIPFDVAAPAVALNCFADGGTNVHAVLQAWEGPTRPSRTPLAAPVFARRRLDARTSHASAR TAAAWPRYVAR BTH_II1666 DH ACP KS9 ACP KS10 KR ACP KS11 DH KR (ACP) ACP KS12 ACP ACP MEDQVVLTSQHPLLDAHRIDGEPWLPGLAYLDLVYQLGEARGIAFERHALHDLTLHAPLAVADGEAVVLT LRWRDERADGWHLTIEGAPLDGGEGAAPRRLVTVRLREAAPAAFGAMRDGDMDAPAVLGATHDGNVGTAG DIVHGNGEATVVDLASLYARCRSLGLVHGAAMQARGTARLTAEQVLVDVRPATASRQAEGDTERNTDGNA DGDAGPYLFDPALIDGSGIGSAAFFAHLFDDADAPRLYLPLHIGAFRATRPIRAHVLARVRRASVRRRRE LVTVTFEFFDPATGEQIAELTDVTCKAVRDARDGAPARARTDAASGSACSGACSCAAPAAARTVDGRTDG ARTERALPDDASPPPGARAERFVRDAIAARLGVAPAAIDADAGFYDLGLDSGMLLELAETIGAAIGASLA PTLLFEHANARELGAWLDAEHGAAFAARATPPHRETEDAARHAAPRAGAGDANGARDGARAGTDANDAGN ANSSNGSNPVARPPASVRCGSLDIAVVGMAGRYPGARDLDELWANLRDGRDCVTEVPAERWRADDVAHVR SPSGKPVSRWGGFIDAPDCFDARFFRITPREAEVMDPQERVFLETAWAAIEDAGHTPDTLARRAPGGGDA GAPVGVFVGVMQSEYALIQRDALAGAPTPLAVNRAPVANRVSYVCDFHGPSVAIDTACSSSLVAVHLAAQ SLAAGECAVAIAGGVNLSLHPAKYVSCALMDMHASDGRCRSFGAGGDGYVSAEGCGALVLKPLSAALADG DAIHGVIRASATNHVGAVAGIMAPSPAAQAALIGECLRRANVDARTIGYVEAHGTGTALGDPIEIDGLTR AYRAHTRDTQYCALGSIKSAVGHAEAAAGVAGLTKVLLQMRHRTIAPSLHAQPPNPHIDLAASPFFVPAR AMRWEPRALAGGGRAPLRAAVSSFGASGTNAHVIVDAYADARVATHDDAGPSVVVLSAMSEPALRQYARA LRDAMRAAPAAEPLVARIAELLAEQLGVTADMIDPDADWREFGVDAAQRRRLARALEAWLDIDDALPERA ALDSVAGLARQLRREHARAVDAALAGATDLGAARNDGAAALSLRAIAHTLQVGRKALPERAAFVARDVAH LARLLDTFAATGDAPRPDGHRGRARADEQPAEPLSPQHADPHRLAAAWVEGRAIDWAAAYSSGAPRRVSL PTYPFERRRYWVRAADAQSAVRATADGATAPDADAKADVKADARANARADAQAGAHVDAGAAAAAAAAVA DILQSVTGLGPDEWRDDTTFDALGLDSLMIGEFTRRIEAMTGERDTTLLFRFRDLTALAAHLAHRHPAAW RADGAQRASSAASTPAPAPAQAGSPPAALASRAARPAPRETAAAAPLDIAIIGLAGRYPHAPTLDAFWRN LVAGRDCVDEIPPQRWPLDGFYEADPARAAAEGKSASKWGAFLSDVDQFDPLFFGITPNEARLTDPHERL FLETAWACVEDAGYTRASLAALRDGPGVGVFVGASFNQYQLIVSDAAQRRGARQFAAPSQIFSISNRVSY VMNFTGPSLTVDTACSSSLYAIHLACESLRRGESSVALAGGVNLSLHPSKYVSLSLGRFLAADGRCRAFD EGGTGYVPGEAVGAVLLKPLADAERDGDAIHGVIRGSGVSHGGRTNGFAVPSPDAQALAIRRAVAQAGVA PRSVGYVEAHGTGTALGDPVEIAGLEDVFRAGTDDVGFCAIASVKTMIGHSEAAAGIAQLTKVLLQMKHA TLVRNLSHGGAPNPNLALERSPFRVVRDNEPWAAGDGGVRRAGVSSFGAGGANAHLIVDAYRNAPEPRAG ADSGTDDAPALCVLSAKDDARLREMAARLAAHLSDARLGDADLADVAFTLQVGREPMNRRAAFVVSRVRD AIDLLHAIARGDEASGAQASGVLRGDVRAADAQHAPAVDEATLARWPAADAARAIASAWVRGAAIDWMRL RRAPSVRRMSLPTYPFARESYWVPGVAPQSALAPAAGRASRAVDAHGEHGAPRADAPVCPPAGRAQETPG TGVLVLAPQWRPAECSPSASAAPAFDARVLVLCETPASFGAALAPALADGARIVALRSDERDPAARFASH AARLFALVKDELQALAKRPLARALLQVVAPASDDAWDCAALAALLKTAAQENPRLVAQWIAFDAWPDAGG AAARLRENASAAGDVDIRYLDGRRHTLRWAQTRAADRAFGWRANGVFLITGGAGGLGAHVAATIARGAVR PTIVIAGRSAEGAAQTALLDALRSAGARAQYRQADVASHADCDALIAGCVAEYGALHGVVHCAGVIRDGF IVRKRAEDLAAVCAPKVAGVVHLDAATRRLPLDFLLCFSSAAGALGNVGQSDYAMANAFMDAFAAHRNTL VARGQRRGRTCSIGWPIWRDGGMRVDDATLAALEARAGMLPLAIDEGMRTMQDCLALDAPHVIVAAGHLT TLRRLLRVDAGAAGGHAADSADAEAADADARAASPAGANAAVADAAGGDRAGMNTVGPDAPGATALAEGQ AGARAAGESAPGDDVAGTHAASGDASLAAAVAERLKHVLSEATGIAVSRLDADEPFDAYGVDSVVVMTVN RALDDVFDALSQTLLYEYGTLGALAGHLAHAHEAACRDWCGVAAAARPGARAADVRVRDTLAVDMSRPDV RTPDLRVSDARGFDERVSDMRDSDAQASSAQASDMLARDTRDIDAQRIADAERQPAEDGDATAVGRAGAR APGASSDAFVGAAGAAAAPAGRDEPIAIIGIAGRYPQASDLDQFWRNLAGGVDSVTTIPPGRWPLEGFFE PDRARALEAGKSYGKWGAFLDDHERFDAPFFQMSPLEAINLDPQIRLFIETCWAALEDAGYTRRLLAERH GKRVGVFAGITKTGYALHGPRVWPLRQSYNPQTSFSALVNRVSYVLDLHGPSVPIDTMCSSSLTAVHEAC EHIRSGACALALAGGVNLYLHPSNFLELAGVQMLSADGRCKSFGQGADGFVPGEGVGAVLLKPLSRALAD GDHVHAVIRATGINHGGKVNGFTVPNPNAQRELIRATLERAGVRARRVSYVEAHGTGTDLGDPIEVAALA QAFAASGGDRDTGYCALGSVKSNIGHLEAAAGIAGLTKVVLQMTHGMRAPTLHARIPNEKIPFARTPFVL QRERDDWPHAHGDAAQSRIATVSSFGAGGANAFAVVEEAPRRERDARPDRPEVIVLSARDADRLAARIAQ LRGRLREGVPYSLAEIAYTLQAGREAMAERIAFVADSLDALVDTLDTLDTLDTAGGAPNPAAGAAAARVH RGSGVTRKTPLSFLADDDLADTVRAWLAKGKLDLVAQAWASGVDIDWTLLHGDRTPRRASLPAYPFAGER

HALPDAAQPVAAHALHPLLQRNTSTLERVSFASVFGGDEAFLRDHRVSGRPVLPAVAYIEIAYRALREAG VPGDAVRLTDLVWMRPAIVEGEPLHVRVELASEASEASEASDTSDTSDTSDAAGDTLALTIGAAAPSGRG QPGFATVFARARARRVRVAAPAALPLARWRAQCGAAMTADDCYRVFERVGLAYGPAFRTLDTLWRGDGVA VAKLRAASPPAAPHAAADVVDSLDCGLLDGALQAVLGLAPASDAERPLLPFALDACELYGERPDEPWCVV RRTEDARVDVTLCGPQGEPWIALRGLVLRRYESAPAAERGLVALAPQWRRADATPVAAAAAPAFADTLVV LCGAQRLDAGGSADRIRVVTVANDATPIGERFAQTLQALIAETQALLRDRPDAPALLQVVVPDTPAFAPM IGLAGFLRTLSHEAPHMCGQLLLVPAHDTGAALRARLAECAARAHETVVRYGQGPARDVLQWREWADAMP PADAGQTADAHAAPVWRDDGVYLVTGGAGGLAWLLAQDMARRAPGARMVLVGRRPLDARAASSLDALRAR IEYVEADCADADAIAAAVASVLERHGRLDGVVHAAGVLRDEFIRRKTADGVAAVLRPKVDGTLALDRATR DVRLAFFVLFSSAAAQAGNPGQADYAAANGFMDGFAQYRRALVALGERHGATTSIDWPLWRDGGMRIGAD AQRLLETQTGMSAMPGDAGLAFFHRAVRAGVAQVMPLYGNPARLRDALAPAARDDAGSAADAAGASDAGS AYADAGDARGMAGAVLIARLRDALAAALGVARDALDAHVPVGEFGVDRQVLDALVEQVEPGGAVRRAELL DTRLTLDEIASRLAAATRGDAHAAHAASPRGEAGEAQEAPQAYEAHGAHEVPPLAEPRASELVDASLALL TERLADVIKLPAPRIDPDAELTTYGIDSVVVMQVTTQLEKQLGPLSKTLFFEYGTLRAIAARVAHTHRER VRALVERRAAGTQAASAASVASHPAAPHGARPAHERRADADAASVRGAPRAVAARSSAEVSRASATANTN TTTTTTTTATATATATATATATTNTTENAAPHASRGDRDARPPAQQPPGAAAFAAGDIAIVGIAGRYPQA DDLAQFWRNLARGVDSVTEIPADRWDYRRFYDPQKGRLGKSYSKWGGFLSDVARFDAAFFNISAREAQIM DPQERLFLECVYHTLEDAGYTRRNVSRSRRVGVFVGVMYEEYQLYGVERMLEGTPVALAGNPAAIANRVS YFCDFHGPSMAIDTMCSSSLSAIHLACQSLMLGECEVAVAGGVNVSIHPNKYQMLSQGRFASSNGRCESF GAGGDGYVPSEGVGAVLLKPLARAIADGDRIHAVIKATALNHGGKTNGYTVPNPNAQADVIGDALARAGI DARSIGYVEAHGTGTSLGDPIEIAGLAQAFGRHTPDKGFCAIGSVKSNIGHGESAAGMAGLTKIVLQMRH RRLVPSLHADTPNPNIDFADTPFVVQTTLAPWRGAILPDEAGRPAELPLRAGLSSFGAGGANAHVVVEAY DVAGAERGAHEDGPAVVVLSARTDERLAAQARNLLAHLSREPHRDGELDRDGGATLASIAYTLQVGREAM PARLAVIAASLDDLREKLAALVDGGEGLDGVSRGRVDPLGEPLAPGELAQWRAGARLAELAAAWVAGRFD DWTPCYGDVRPARVSLPGYAFAPTRYWVPDAEQLAKAAGVHADATQAKGIAGVAQGSVASGSSGASAEAA GPAESNGAAGSNGSAGSAGSNDAGPGDARKRVAGPSIDAAAPANTAQPAEPAEPAARRRGGVTLSPPAEA AAFDLSARAPAAKPTVTFAQPAGRAHEALPPASRPEESAPRVVATQARRADAVSAAPAVSPEAVVPALRA LLADALYVDAQTIDANAEFVSLGVDSIIGVEWIDAVNRRFGVALSATTIYDHPTLSSFARHLASAAASAQ ASMAAAASPSAPASGARADTAAPEAAAEASAPFEREQAARARAAAHGADDAGDPAPAALEAALRETLADA LFADAHDIEPDATFQDLGVDSIIGVEWVQAINRRYGTSIPAPQIYQYPTLRAFGGLVASELALARRRAGG APLPDAEAASATTATTASASGTAHAPNAAGDAHAPNAAGARAATPAPAENAAGAVHAARAANPANPATLA NPAPGGGVPLDDVLARVHRGELSVEAAEALLAGALG BTH_II1665 KS13 DH KR ACP KS14 DH KR MT ACP KS15 MERQNLRNVLERLKAAAIGPDEAKRMLSAARAGDAADKPQPGPAAAAPRDAEPIAVVGMSGRYPGSPDLD AYWSLLARGEDAVKEIPPARWNVGEYFDAEPGKPGAMYCKWLGALDDVDSFDSLFFRIPPSEAEFIDPQH RLFLEEAYRAFEDAGIAPGRLGGRACGVYLGIMSNEYNLLLARNAPDSGHAVANHFSIGAARIAYHLDLK GPAIPVDTACSSSLVAAHLACQALRAGEIDVALVGGVTLYLSPDAYIGMCAAGMLSPDGRCKTFDQRANG FVPGEGVGALVLKRLADARAHGDPIHGVIVGSGVNQDGRSNGMTAPNGASQTALERAVYERYGVDPDSFQ YAELHGTGTKLGDPIELAALADAFRAYTGRRGFCAIGSVKTNVGHTSAAAGVASVQKVLLSMRHGQIAPS LHFREPNEHFDFAASPFYVSTALAPWPTPEHGPRRACVSAFGFSGTNAHMVLQADEPPSAGAAAPGAPAG GAPHLFVFSARTEPQLDALLDTYVAFLRRTRVAPESVAYTLQTGRDAMACRLAVRASSLAALADVLEQVR ALACPDGVWRGRGAHREPAEKIDAALRARDLDTLGECWANGQTVDWAALYPHARPTRAHLPTYRFAPARH WFQAAPATPPDAAAVTAVTAAVVAAADDAAAATPFEQRASIPADAPCFVDHVIDGERVLPGSAYLELVRA ALADARREPASGCLVLSDVRWRRTLQAGGGVRLRVVLSARGAPAAWKVVSADDGAIVYCSGSAQWEALAG ARVDIDALRARVASATAVDANACYRRFASLGIEYGASHRLIETLSGDAQRALARLRAHGDDACAGEAADA LPIGRLDAALQSVLGLALGDGGEGPSDAALPLGIGRLELYGPCADVVWVSVERARADGDVTLTLANADGL VRAAMRDITFAPKPPQHRAVPLVGAWRRARPAAPRASDAAPRWICLAGPLAAHAARVEQALSPARVAALP GDADEAGEHYASCVLTLVETLQAIARDHAAGARVDVVIPGDAAFHGHRGLASLLRTARQEMPRLRVALVE CAAGAHAVVDALRAVQEHAEGEWQWREDGAWRRTWTPAELRGGGAPWRDGKLYWITGGAGALGMLLAAQI VEHAPAARIVLSGRSPLAGEAAETLRAWRERGVAIDYRELDVADRDAVVRTVREITARHGPLAGVVHAAG VRRDGLLIAKTREDVEAVLAPKVRGVLNIDAATRGQPLEFFVLFSSIAGALGNVGQADYAAANGFLDGFA QYRNARAARGERRGVTRAIGWPLWDAAGMTPDADTLAEIARAGLAPMPPSHGWRMLHAALDAPHDALAVL YGDARTIAARLAAAEMADAPDEAGAAGDAPAGGRGAGGGDAGLRAPVLARLKAMFADAFKMSPDDVLETA EFADYGIDSIVVLRMTRQLEKHFGPLSKTLLFEQRRLDDLADYFVRAYEAACAAWIGARADAARAGGARA DHANGANGSADADAAAHAPGAVAAGSDAGAFDLRGRAAADGSAADGGDRMSGAIRASRECHESDEACARR AAASPDASPPRARPPHAATGARMNIAVVGLAGRYPKARDLDAFWANLAGGVDCIEEIPAERWDHARYYDS DRDATGKTYAKWGGFVDGVDEFDPLFFNISPKEASVMDPQERLFVQCAYEALEDAGYGRVALGGERPHGA ERNIGVYVGVMYEEYPYFGVEHTLNGRPMALSGNPSSIANRVSYLLDLHGPSMAVDTMCSSSFTALHLAC ESLLSGQCRMAIAGGVNLSLHPNKFIALAQGGFAASDGRCRSFGEGGDGYVPSEGVGAVVLKPLAHALAD GDHVYGLIQGIAINHGGKSNAYTVPNPDAQAGVIEAAYRRAGISPRDVSYLEAHGTGTALGDPIEIAGLV SAFRAFTDARQFCAIGSVKSTIGHCESAAGISALTKVLLQMKHGRLAPSLHARTPNPHIDFDASPFVLQR TLAPWPAPDGGTRIAGISSFGAGGTNAHVVVEEYRAAAAHAHDGAQAAASPAAVVLSARDDARLRALAQR LRDAVAAGRFAPHALHDLAFTLQSGRDHWERRIAMRVESFDELHAALDDFVAGRPVGARHWLGACRVGGA

SRRAPEPCASLDDAAAVWASGREVDWSPWRGARACRRVSAPTYPFARVRCRIPDAPASPAAPRDGAPSHP LLHRNRSTFGAYRFESHWRDSDPLVRDHRVQGRAVVPGVAQLELACAAFARLQPEGADAPRGVVRLADVA WVRPLVVAPHAHVRVDVAPPGETAHGGAASWRVHASAHGGDWQLCSQGDIRRVDAAAPAERADLAALRAR CAGRAIDADTLYRAFASLGIEYGPAYRALVDVQVGEGGAFARLALPEAAASSLDTCAMPPSLLDAAFQAA AAFAIARAANGDAGEDGPAPLPFCADAVELHARCAARMWAHVRMRDGKRDAVDIDLYADSGERCVAVRNL VSRRATHVAAANMAAGIAAQPAGANAEVAFEGNVEADANAEVDIEANIEANAEAWRAPDATGDIVLAPVW EIVDAAAGTPFSPGIVVADDAAERARWAERCPHARIVGADAFAAREVAAALGAVDAFVWIAPRAARGGAL ADSPALDCAANCFEWIAALLAAGAANRAIDALFVTSGCRAIAADDPGDPAHAAIAGLVGALAKEHPRWRV RIADHASAEPAPVDALLRLSPDPQGDALAYRDGQWLRRRLLPVARETMGEPAAHRAGGVYLLIGGAGGLG VVYSEYLIRRYGAQVIWVGRRERDADIDAAVARLAALGPAPVYRRADAADPAALRAVCDDARARFGALHG VVHAAMVLADRSLARMTQQTLRAALVPKIDVARSMAAVLLPAADLDFMLFFSSMNAFTTQPGQGNYAAGC TFVDAFAHALRAQAACAVKVVDWGFWGSAGAVATPYFRARMAEAGIGSIEAPQAMRVLERLLAGPHGQLA MIHAIRPTMQDGARRWLAAAPEQAAAWRACAPAWPPAPAFDASAAAALDAALAGTLAARLAALGWPEQGL PRASCAARLGVAPAHAAWLDASIDILKRAGLASEAADGTVTLAAAAARPETNADAASGAPTSAPGTDGAH GQSAQLALLRTMTDALPDILRGAKRATDVMFASGSINQVESVYRGNAVSDYFNDVLAAALDAYLSHRART APGEPLRILEIGAGSGGTSARALECADRFAPQLVEYRYTDVSAGFLAHGRATFAEGRPYLAFAKFDVERD ARAQGLEYGRYDVVIAANVLHATRDMQRTVASVKSLLKRDGLLLVNELSANTLFTHLTFGLLDGWWRFDD GFLRLPGGPALAGAQWRALLASAGFHSIAFPAADAAGHGQTIVCASSDGVVRLDAADATGADDADARGDA SGAHELAAAPLAAHRDGGRGSVAAVADAEPDADTDADADARLRDAASAWLRARIGAALDIRADDIDSRET LERYGIDSITVLQLTKRLRDAFDDVPNTLLFEYNTVDALVDHWLATQPDALRAALAKDAGEAVAGAARDG RESGRAASDAASAHAVSGAACASVDGAYASGARCGDDIRIATDAGRATAPATVTTAAPIADSKADSKTDS TPPYPPHAREAEPVAVIGIAGRYPKAASLDAFWRNLRDGRDCIGPLPAPRGDWRSSGGAQGAPIGGFIDD IDRFDPLFFQISMREAQSMDPQERLFIEQAYACVEDAGYTPATLSATKRVGVYVGVMNGNYAGGTRYWSI ANRVSYLFDLHGPSVAVDSACSSSLTAVHFALDALRGGSIDCALVGGVNLIVAPEHLARLSAMNMLSTRG KVSAFGADADGFVDGEGVGALLLKPLARAQADGDAIYGVLLGSAINAGGRTHGYTVPSPHAQADAVAGAY RAAGVEPHMLGYVEAHGTGTALGDPIEIRGLARAFERDAAMRGGCAIGSVKTNIGHAESAAGIAGLTKVL LQMRHRRLVPSLNADTPNPDIDFSRTPFRLQRRDEPWALPAHAAWPRIASVSSFGAGGANAVVVAREHVS DARVPRAGAASAQAIVVLSARDDDRLAARARQLLAFLRDAPDDGDTLARIAFTLQVGRVPMAARVAIVAG SLSELADRLDAFVAGDERAAGVHRGRPVPPGASVVHVAAAHATDAAARAVLARGVPDDIARYWADGGNPD WTALHAAHTPGRINLPAYPFAGERFWLSPAASGDAPARLAAAGAGANAAAAAAGTGEAFATAEAAADTDL ADIDTDIDTAIEIAAADVFAELAAFAETGATRDDDLPSLAELFGEPDANADDADDDVDVAHLRDVAAQTL GVVPELIEPDAPLRDYGFDAVSLALFAQTLNATLRPRAGRRRVCAAQCATAGSLTELARQLRFAALH BTH_II1664 MT ACP (KS16) OMT ACP TE MRRAMRDGGKPDRIGAAAPLRRAPLTATSGIDMNVQESIFPITPNGFAGHSMDDLMQRWLLAQLQATGIL ADGRAHAFDALAGRVQPLYRRWLEESLRLLRDAGLVRDDAQGWRAAERAPIDARDAQRHWDASRDAWLAD RERAVYVVLIEAVLAQLPAILTGRRRATDVLFPNGSMARVQGVYTGNHVSDHFNRVLVDHAVRYVAGCAA RRADAKLRFIEVGAGTGGTTEGLLAALAPHARHVGEYCFTDISKAFLNHAQRRFGEGAPFFGARVLDIEQ PIDAQGFEPGAYDALVATNVLHATRDIRTTLRHCKALLKHNGLLFINEMTGSVPYLHLTFGMLEGWWRFT DDALRVAGCPAVAPQTWDRVLREEGFSSVIFPARDAHGQGQQIVIAQNDARRAGSARRDARASNGDAQHG ARHEAAHDAQQDASGDTQADAHDSAHDSAHDSAHDSAHDSAHDSAHAAAALRREGRAYLRARAAELLGMP AGAIDPDEGLHAYGLDSILASQFAAQLAEAFDGFDGALLFEHKTINALLDHLLAAHADALARLLPPAGGA PARGVGARAQAAQASGEGRAAPPAAPHADARSDTPSSAPSSAPARPDQPAPSGPPAQPAQPAPRADTPPP AASAGHRGEARASDTRYAPRAPHPDAAAEPVAIIGISGRYPGAYDVPAFWRNLLAGACAITEVPAERWDW RAHYRADAAEAAREGKSYSKWGGFVDDVGRFDPAFFGMTPQDAQHTDPQELLFLEMCWHALQDAGQTPAL LPGDVRRRAGVFAAITKHYAFPPTSFASLANRVSHALDFGGKSLAIDTMCSSSLVAVNEAWEYLQRDGRL AVVGGVNLYLDPQQYAHLSRFRFASSGPVCKAFGEGGDGFVPGEGAGAIVLKRLSDAERDGDPIHAVIRG CAVNHNGRSTSFTASDPARQADVVRDALTRAGVDPRTIGYVEAAANGHAMGDAIEMTGLGKVFAACDGVS GTRAIGSVKANIGHCEAASGMSQLTKVVMAMRDGVLAPTLRDGTRNPNIAFERLPFEVQEQAAPWRRLIV DGSEVPRRAGVTSIGGGGVNAHVVLEEYVAPPRAARPGAGTDDEVLFVLSARTREQLGAYAERWAGYLEA HPDCDVDAIAHTVRTAREPMAHRLAVLAHGRGELAALLRGWAAGGAASGAASGAASDQVFYGDVKQHRVV LSDALVQAARREGAASLAKLWVLGNALGAAHGADEPAPRRVGLLPPYPFERRLVWTSAHAPGTRHASAGE ATEAAEAAEAAEAGAAAVAESAEAGAPAAAGDARLQPAPASNAEAFYSLSTLNASKDFQEQYLTLCPFPE RIPGFSMTRMFIEPQKYPNEFALMQARQIEMRQVLFGREHFERISRVLDIGCGMGTDVIQLAKRFAHLRT TGYTITRAQAELGAGRIAREGLQGRAEIRHGDSAKDPFPGKYDLVIGIEVICHIQDKHGVFGNIARSLDD DGHVLLMDFVANGRGRISSPEIDIDIGTRQDWIDVAAAHGLVVDEVIDVSPQIANFLHDPEHERNIAALP GVAQASFRNFANTCVSLEKGWVSYCLLRLSKASRLSEAERRRLNAERFGASVAYPDALKAMHARGPAPYP RSPDAQPPAARAQAGVDGGVEASAPAGVKADSKAGPKSEVKSDAAARASRADIAASVAASVAASVEDAFE ASLGLRRADLERADDLRALGIGSIQAVMLAEAINERLDLALPSRFVLEHATFGALVRAVAEAVAGGRGSS RDAPARELAYLSLLEPGGAMTAELLELPGGARAEILRGGRGPRVVLIPGLGMAGTVFRDLCRALTRRHEV IVYHYPGLGRSDPVAPIDVDAAAAHLYRTLDACGGDGAAALLGWSFGGVIAQRAALMRPRAWRALVLVNT LGAYRPLAPQFLTPGASRDGEPRGLGGLYQTDLDFVFAGDAPPAALARKDACAALMRDSLALDAAQAIDY LDALVRFDATAQLPSLRMPTLVVAGTADHFGDPAHAEQLVSLIPNARLARIAGAGHAVFLTHGEAFEPAV LAFLDETLRAAEAGGAAESVESVEATEAAEAARSPAVARRRATDDAPVGSDA

Chivosazol ChiB ACP KS1 AT (AT) KR ACP KS2 KR MT ACP KS3 (DH) KR MT ACP MDGGSFDRESDREDRSSDKKAALVGALRRAAAELLGRAKEDIDPGVPFRTLGLDSVGAIALLRRLSAEID RALPLTLLWSYPTLESLATHLARGPAKERAAAEGTPERQDEPIAIIGMSCRFPGADDIDAFWSALCRGES AIRSVPPDRWETAPGGGEEGAAPDRTSASRWGGFLDRVDGFDPLFFGISPREAADMDPQQRLTLELCWEA IEDAGVVPATLKESRTGVYFGVLFGDYAALQSRRGIEAVTAYSSTGTSHCIVANRVSYFLELNGPSMTVE TACSSSLVAAHLACQAIRAGECDLALIGGVNLMLAPDAAIGMHKLGVMSPTGRCWTFDARADGYVRGEGG GVLLLKPLSRAQRDGDRIYGVIRGSAVNNDGPSNGLTAPNPRAQEAVLREACARAGVAPRSVQYVEAHGT GTELGDPVEAAALGAVYGAGRPAEDGLRIGSVKTNIGHLEAAAGVAGLIKTVLCLHHRTLVPSCNYETPN PHIDFGALRLGVVTGLAPWPESGEGPPRAGVSSFGYGGTNAHMVLEGLPERPTHLLPLAAARPDELAEEA RAWLRVLDGGARDVPLGELCGAAASRVRAAPCRLVAEGASRDALRADLSARLASVASLKAPPGAAPEGAA RPVFVFPGIGPQWAGMAQRLWMAEPVFQQALARCDAALREAAGWSLTEVLWADAARSPLADPDALEAAFP ALTAVQIALVDLWRSFGVEPAAVVGHSSGEVAAAYAAGILSLDDAMRVARELGAIYQRTVASGDGALAVV GANFEEVERIAAEQGIGGALHLAARNAPGSCLICGGRAALQQLLGTLESRGVYCHGLNAMSSHCPLVEPF AEAVDRLSARLSPGRAVVPMISTVRAGPVEGGELGWHYWRDNICSPVRFDEAMRALALHHRIYLELSPHP ALLRYIPPHFDGAGEPPLVLESMRRDEDEHRTIRSAAARLFEQGAALRWEGLESAGDRRVLERELLDDGG ERRQEPQPQEPRLLPISAHTEEALADLVGRYRDHLARAAWPALCASAARRRAHHRRRLAVVAASGAEADR KLGEVLRDGSRAIEGVARGRSSAEGPPRVVFVLPSYEAAGAGASSAARVLSRWSPVFREALLACDRALAA HGCGVVAELLAEGGASRLARPEVAHPAVFAVQIALVALLRSWGVVPEAVVGEGLGEIAAAHLSGALSLDE AARVVGGAALDASHSSTRNLREPSRLDEAIQGIALGRDALFLEIGPEPALAEVIQRSLQRVEAQGVALPL LQAGRDEREMMLRAAGELYCRGLDLDWSGLSPGGDHRVPLPRYAWQRQRYWLPDAPAPRSAPGASTATAS GASATTTAPPAAAAPPAAAPPAAAAPPAAEASHAVRFYHAAWREAGGAAGAPPEGPVLVLARDPSAGRAL ARHLRGQPVVVVKPGEAFLQEDDTTFAIEPRRADHYRLLAEKLRERGAAPRHVLHLWSLGAEAARESLAD KLDRGIHSLLPLLQEMRPREGGAPLSVRYVYPSSDRDPGHVHAAVAGFARSVRQESDRLRLEVVGLSVAA HEAFHLDAWLGRIVGAWDGGDEVEVRFEGSRRLVRRFAALDPALSSEGSLALRAFKDEGVHVITGGAGGL GALFARHLARTSRARIALCGRSAPDPRTQAVLQEIDALGGQAAYFQADIGDSGQAAALIQAVKRRFSRID GVIHAAGVLRDGLCLSKTRKDMAEVLAPKVLGTLALDEATRDEPLDFFVMFSSFVGALGNVGQSDYAYAN RFMDEFAVWREAQRARGARTGKTLSIGWPLWREGGMQMDRSTAQRLELTLGMSPLTTATGLDAFDRGLRL PHETFLVLEGVPERLDRALGVGTTVPAARPRSAPRRSATAAEDAALNARFQAELLEIIGAILSIAPRDID PQEEMSAYGFDSTTFVELTNQLNTSYGVDLTPSVFFEHRTIGSVVRTLCGSHGDAIRARWSGPAARAGDG ASGEPRNEGTAQGGPRVAGGAPPAKAAPRRFQPAMAAGPLEREPIAVIGMSGVFPASDSVDELWSHLEAG RDVIEVIPRDRWNWEEHWASSEELDKTAVRWGGFMKHVDRFDAAFFGISPREAALMDPQQRILLEITWKA IEHAGYRPSSLSGSRTGVYVGIGNADYREVMARRLVPAEAHLATGALSHAIAPNRISYLLNLHGPSEVVD SACSSSLVAVCRAVDALLAGECDTALAGGVNVIVSPTLYISLSKAGMLSPDGRCKTFDKDADGYVRSEGA GMLLLKRLSRALEDGDPIHGILRGHAVNHGGRVNTLTTPNPSAQAALVAEAWRRAGVDPATVSYIETHGT GTKLGDPIEIEALKKAFEALFAQQGAAAPDAPFCALGSIKTNIGHLETAAGIAGLIKILLAMKHKKLPGN LHFRELNPYIRLEGSPFFVLDRTVPWDPIEGAPRRAGISSFGFGGVNAHVVVEDFEASEARPGAAAVDAR APRVVVLSARSEERLRAQAAQLCEHLRRVPFGAEPEVSRDLADLADLADLVGRDLLLMAAGVLRHEPDDI EPEGDLLEIGFDQVGLSVFTSRINERYHLHLTPHGLGAHHSLRTLAQHLCHSFEAPLRDCYQAARAPSQP SPAAGPIALADLAYTLQVGREPMNARLAVVASDIAELSDKLGLFVSGRDRIEGLFHGSVRGRDDDLMHLV SGTEGRAFLDAILASQNLAKLARLWVLGAEVDWEMLYSPGEAPRRISLPGYAFARDRHWFSPPEAPAARA RDDRATILDDSSRGDARLDGISVTESERAAGTARGDSMLFVPRWVPRALPAPAAGSPAPWAERTLVLYTQ DGAPLKEALVELLGRDRVVARRIEGGRGRTGEGPLELAMPGEAFGAVIFLGGVRARPWDVEDAQALEEGL EHGAFALLHLVRELAARRAVDRPRRLCVVASDVYPVLPGAHTNPAGATLYGLCRVLAHELPELMVSCLDL GLDEQGGAAESSALLGLARAVLDEPPHPDGAVTAIRRGQRTCRVIAPALLSEPAADAPTLRPRGTYLILG GAGRLGVDVSRFLARKLQARLVWVGRSPLDAGIQAKIAAVEAEGGEVLYAQADAADPAALRAAVAHARAR FGAVNGAFHSALSYQGAPLASMDTDTFARVLSPKVQGSVALYRALADEPLDFLVFFSSIQSFTGDKSQSN YAAGCAFKDAFADHLRARAPFPVKTINWGYWQSGDEEYDRRLVTLGYQAMPPEAGMEALLRVLSSPVHQA LAVKADDDVLAAMGVDLGHEVILLPRRYPALLSTTPAMGAAPAAEEVGRALNALDELDRWGRRALARQLG AMGLFRAKGRSIDREALREHLGILPRHGRFFDAALSLLAREGVVRVEGDRVTVGAAPAFAVEAPGAPSGP AFSGIGAHVALLSTCLQHLPAILAGEALATELLFSGGSMARVEGIYRNNPVADHFNRLVARRVVEIVRAR LAHLGEGETLDLLEIGAGTGGTSAVVLEALAPFASRIRYVYTDVSRAFLRHGEQTFGQAHPFVAFERLDI ERDPGEQGFLPGSFDVILATNVLHATRSMRATITRVKRLLRAHGWLIVNEQTAVQDYNTLTFGLLDGWWL SEDSELRVPGSPLLDAEGWRGLLAGLGFERIGLESTSIEGLRPTQHVITAESDGWVLGEARRPASGQLGA RAVVARERSEPAASERGTRPVEATSAAPTGRPAGARSGEAVKERIAHRVAAEVALALGSTVAEVPTSAPF VEYGVDSIIGVDLVNRLNGAFGTALRATVLYDYPDVNALSELLWQEHGEAIATRWTEVARLDGEPPTRLP EEQAPHRSADDLFRHGPSRRDVPAPASASASAARSLAAPAMFTQADDGAAVGPAPRVVSTDIAIIGMSGR FPGANGLDAYWQNLAAGVCSVTEVPRDRWDPAVFYDPDPRDVDKTYSKWGGFLEDIDSFDASFFNISGKE ADLSDPQQRLFLQEAFHALEDAGYADASVSETRCGVFVGADRGEYLSLLRDEGARREGQCVWGNDVSVLA SRISYFLDLKGPALAVHTACSSSLVAVHLACRALMDGDCDMALAGGIFVNLTADWFILWSSGSMLSPAGE CRAFDNRADGFVPGEGVGVVVLKPLHAALRDGDRILGIIKGSGVNQDGRTNGISAPSTLSQTELEVSVYE RSGVSPATVGYVEAHGTGTKLGDPIEVEALTRAFRRFTDERQYCAIGSVKTNIGHAATAAGMAGLLKILL AMQHGEIPPSLHFREANEHIDFASSPFFVSTARTAWRPIGGAPRRAAISAFGIGGTNAHLVLEEPPARDR

APVRAAWPWYPVVLSARTEDALHRKIADLDRWLEQGGADSDLGDVAYTLAAGKPQFKHRAAFVASDGRGL LESTRAALREGAAEGFVSPRSTAQPAAPQESGGRLVGELREARALPPQSVREKLLALAELWVGGGAVDWK ALLGEGSYQRLSLPTYPFAQERHWFTARGAGLSPRSGPLHPLLDALELSESLGEGLSYVKDISGAAGVDL RLAGQTLLCPFALLEMARVALEHARPGSGSGLRAVSWGDLRPLHGGVHRLRVALHRQDGGLAFRIQADGK EGDLLSGQGAVDAPGEGTGGEIAIASVIARCPRRLDGEAFHASLEPRGLHEQAERRVIQVVHVGDGEALA RYELPRSAAREPARIWLHPALLTGALHVAASLEEDRIEASVPASLAGVEVSRAPRGSGFLYARKIAEGRY HLAILDEEGQVCAKLQELRTRPLRRGARCALFLPRWVAAPSRAGEGSRPDAGGRDAGRTVVVVYPPAEQA LASALTEVYGGERVLAVRLGSRTRRLDARSWEVDTADPGAWEQPLRDASLVSTLHFLGGISRDEASLHDG EALDRCLNQGLFALFRLVKAVSRAGLMLAPLRFQVVTSRAFPVLPGEVNALYGGALLGWSRSLAGEYPGV RVEYVDLDLGEAGEPLTGAAREAVLGALMDGSAEVAAWRGGQRFVPTIEPLSVPANERSAFRPGGVYLIV GGAGGIGHTLGLHLARRYKARLILIGRRPEDEEIRGKVRRIEALGGAALYLRADVADPVALRAAVDAGKA RFGALHGVVHSALRLEDRTIDRMDEATLRAALAPKVQGSQVLCAVTRGEPLDFILFFSSAQSQASRPGQS NYAAASTFQDAFALGLARRLDTAVKVLNWGYWGSVGVVADDRHRERFAAMGIGSIEPDEGMAAVEQALTA RVERVMPIKAEPHALVELGCDLGRQCQHYPESGLPVLQHARSSIGAPPAPAGVLLAFHDGFGELVRLGQR CLLAAFQRLGVFRASGERYELAALKAALRIAPAHERLFPVLLAHLAEAGWLELDGGGSRITVRSAPRVER ASLEHEKERLLARRPEIRHHAELLWLCLERYPDVLTGAVAATDVMFPGASMEKVEGVHKGNVLTDYVNRR VVDVVLAYVRERSPLLGGDERIQVLEIGAGTGGTSEPVLEALAPYASKVRYVYTDVSRAFTRHGADAYGP AYPFATFALLDVERPVEQQGFSPASFDLVLASNVLHATAALRVALANAKALLKAGGWLVLNEVTENHPFN MLTFGLLKGWWLFDDATRRLPASPLLSAPMWEQLLREEGFTTPVSLGPPGGMVLGFSQHVIVAQSDGVVS LPRQAAEGAEAEQTANARAPGRVEQAPGGAEPAAPHGRHANGNGNGAGPAAPPRHANGHGAEPAAPPRHA SGNGAAPPRWQGPPEAGKPEERAAQIGRDVERAIVACLGEVLQTDRQRIDRDAPFTELGVDSLLSIRIVD RINKQLGITLRTTDAYSYPSVRELAGHVLSSFAADVRLPGAAKIDTAALFGDGAAPAPAPAPAPVDEPRG GEPEGDEPLWRLLRGVESGALDVNEACRLLELP ChiC KS4 KR ACP (ACP) KS5 DH ACP ACP KR KS6 DH KR ACP KS7 KR ACP KS8 KR MT ACP (KS9) ACP MKRDPRVIFEQLKNGQISRAEAHRLLKARSDGREQEATGPGAEEGAAAEARAPSAPPPQPASSDSDVGVE VAVVGMAATFAGAADVDAFWRNLVEGRSSIREIPEPRRSHAGFRDPDPFDASGRRRRAGFIDDVGGFDPL FFNISPLEAEFMEPQQRLFLQAAWHALEDAGCSSERLRGRRCGVFVGCSADSGYLHLVEQSSANAYQLMG IATSILASRLAYFLDWKGPAVAVDTACSSSLTALHMAFRSIREGESELAVVGGVAAFSTAVIYDLLGKAG MLSPDRQCKAFDRRADGFVPGEGVGVVVLKPLEAALADGNPVYGVIKGIGVNQDGKTNGITAPSAASQAE LIRRVYTEFRIDPEAIGYVEAHGTGTKLGDPIECDALTDAFRSFTAKRSYCALGSVKTNIGHTLAAAGIA SLIKVLRCLDRKQLVPSLHVEAINPHIALDESPFYISTEHRDWDAPPGRPRMAALSSFGFSGTNVHAVIA EGPSAPPRRARSRPRYFLPVSAKNQAALAAKIRDLARWEGLSRVDLGDLCATALLGRAHFPLRAAFLFSG RDELVRGLQAVAAGEPWPGYEVRDLKEDPCEPEPERLQRGRVLLASLTSMDPERYAEALAEVAALYLQGF PLDFGQLYAGEPHRVVPLPLTPFAKKHYWPPVPASPGAAGGARAGSRAMILEKNWRPSPSTMPASDGINW INAVNVINGVHGIGAVPGAGARASGPAAGGRVIVLSTPETASLVEPLRARFPDLLPVRFGRPGQDVWDVD SAVSAAREALRQSPSIEGIVDLTDAGAAEVGDVAEVAPKLAFAGEILAERVHRDLFYVHLTRGLAGVSGR PSRKAGALFSGLVRALAAEHRRFRARTVDVEPDAAPEVIAERALREAGEPGPEVEIAYRDGQRLAPRLEP IAGGGRARAPLACDPRKVYVITGATGGIGQLLASFLVDRGARRLVLMGYRPLPPRDQWERVAGDPGADPR VRRALQQVLDLEARGARVISWSGSLVDERRLEELFAGVRRDLGPIGGVLHAAGLAPSSNVAFIQKPLPDF LRILEPKVQGLEVLHRLFSRDALDFFVLFSSVAGVLPALGAGLSDYATANAFMDHFAALHGAPYLALSWP VWEGVGLGEHTSPIYRQLGFLPHAEAQGLELLEQAMAHEGSAHLVPCLVDPERFDTTVLLHARQGSHAQQ GNHAQQGNHAQQGNHAQQGNPARPASPPVSEGASTDGVSRALAGLRELFARELKLAEHELHDNTRFEELG VDSVLLIGLIAKVEKRVGSKIDPSLFFEYPTLARLAAQLGSSWKEPAPAPSAAALAARPPAASAGHAAAA PAREGSATLQWVRGQLAGLVKVPEAELDASTPIEELGIDPTVLTSLRHHIEASFEVALDPAQLFEHRTLE RLCGWLDEACPAITRAISAGSSGGAHAGAAPRGAYDSAPVLQARLESAAPGAAGAAAAPRPDRIAVIGMA CNFPGAADLDTYWRNLAAGKSGIAEVPPSRWPVERFYSATLEPGKSTGKWGGFIEGIELFDPEHFGFKPE DAPSVDPLIRQALQVATQAFRHAGYERRELGGRAIGVFVGGRVGDYGERIHMGTKSVMASTGQNFIAAHI SHVFDLAGPSLLVDTACSSSLVAIHLACHSLLSGEVEMALAGGVDLLLDEKPYLRLSESQALSPDGVCRA FDEKASGLVPGEGAGAVLLKPLAQALADGDRILAVIEATAVNNDGRTMGITTPNPDAQARVVSAALRRAG ISARAITYVETHGTGTMIGDPIELKALTRVFREDTDARGYCAVGSIKTNIGHLLSAAGMAGFIKVVLSLQ NRQIPPTLNCETPNPRFRFADSPFFPNLRLREWEQGGDLGRHAGISAFGFGGTNAHVIVGELVPGLAEAG RALRPPLPPVQFNLRRFWLDKVAAGAGPALAARGTESAARVAEREAREPLPPLLRVEARGAPASEGQLPP FRVVITNEDPIVRDHRVHGVRIMPGVTFLDLICRALQSCGHALERVELRNVLFSKPLVTADAYDRDLEIR FERAGAFWKVAARSRKVKGGRIVEDAWEEHCQCEAHLTREPLAGALDPGAIERRASRVADLDEAYAFARS VDIRHGVFMKNLGEVFFEPDGVLARLVLSESAQAYLPHFAFHPVFLDGATLVPALFVKEAQQAADKPAVP IYIRSFRAAKAPGRACYVRVLRRTAENLLGDLMYVDLDLHDEQGQLVARLSRFGTKRIRSSALITRLQGA GHAGAPALLAGEAPPPEARPREHAPDAAAALKARLRQLVAGRLGRDPESVPTERGFYELGLESTDLLDLV RELEALLGEQLYPTLLFEHATIDELAAYLRRAHPDRLAAAPTTASAAPSDAAGPAGAAGALDTPDTLVTL DTPGSTFATAPLEDALRRKIAGLLGVPPAQVRSDSGFYELGLESTDLLSLARELEALLGEQLYPTVLFEH PTIDALVAHLRREFPGRSLGAPETPRSVASEAEEQTLFLRPEWRDAQRRTSSKEPFAPVLLFADDPALRA HLERKLREATGGAGEPSPVLLIEPGQRFEAVDPATYRLDFGREDDALALLGALVERGLAPRTVVVMEPSA PPGEEPSALEALSRSSLFTLLSLVKALVARRLGHAVRVLHVHGEIDGLSRPLHAAVAGFARTVTAELPSS

VSCRILCVAAPARLSPSELAELLWPEIVYPDTAAEIRLAGGRRAARQWREIPLPLAGEGPRPVDQGVYVI TGGAGGLGFLFATYLARHHRARLVLAGRSERSADIDARLEQLAALGGQAIYVSADIADRAQVAALVAAAR ARFGRIHGVLHAAGVLRDGLAVTRSRQDFEAVVAPKVLGAVFLDEATRGDDLDFLVLFSSTAAIAANPGQ SAYAFANTFLDRFAEARDRLRARGERSGKSLSIDWPLWRDGGMRVDPRVEAHLARTKGVQPLSAEAGIQA FLAGLSSSGTSFAVLRGQADKLRAALGSALAPREETPASPPAVVRPPAAATDREPVSAARATAARAASPP RERGPAPLDVAIVGVSGRYPMAPDLDRFWENLEAGRDCITEIPAERWNHSAFFAEGSPGKAYTRWGGFLD DVDRFDPMFFHINPRDAATLDPQERLFLEIAWQALEDAGYTRAQLGGKRVGVFAGVMWGQYQLHGVPPSD LGHPIALSSSFSSIANRVSYFFDLSGPSMAVDTMCSSSLTAIHLACQSLVSGESELALAGGVNLTLHPNK HLFLSQGHLASPDGRCRAFGESANGYVPGEGVGAVLLKPLDRAIADGDRIHAVIKAIAINHGGRTSGYTV PSPAAQGALIEDALRQAGWPPRTVTYVEAHGTGTALGDPIEIAGLSRAFGPAAVEPGRCAIGSVKSNIGH LESAAGIAGLTKVLLQMKHRQVAPSLHAARLNPRAHLDGSPFRVAQELAPWRPATDAEGRALPLRAGVSS FGAGGANIHVLLESHEDPASAAPSPGSDPAGGQVLIPLSAQDEERLAAVARRLRDAMTRREEAGPSPSEE RRFLADAAYTLQTGREVMPARLALVVSSRRELVDALDRFLAGEGGGFVAGSAAGSTSPWTAAISGEDAEV LIERWLHQGALDNLARLWVTGVAVDFRRLPGSRGRRRISLPVYPFAGERYWVPVPVPREPGLVAPLHPLI DRVVPRLGAGEVVFQRTLWPEEPIVRDHLLHGRPALPAAAYLEMARAAAALVEAPGAAPAAASTAPTWPA DVVFLQPLWVDQPVDVRVVLTEASGRRSFEIRSEAGGRQIVHARGALLPAAVGPAPARLSVAQVEDGARL SSGEALRARARAAGLHHGPTLHCLKSVRIKGDEVLGALALEPAAGPAFREDRRVVLHPCLVDAAFQALTG LLDEGGEGAGRTLVPFSVGRVEVLDALVSPGHVYVQRAGELRFHVAILDDAGVTRALLHDVTVREYRDAR APSLFVPAFQERPLPEPPRAAAPRGVLLVHPAAVSGWIPALSSAFPPGTVRRIQLGAEERPLGPGAWSIR ADDPEALSRLLDGAAGDALDAVDTIYFLGGLSPAPFAAADLSALGRSQEHGVLTLFRLLRRLHVLHATHA HRALQIKVVTNDALRVGREAVLNPGAASLVGLCKSAARELSRWQFAVLDVPLLGGRGEDLGARFGALVPA IVAETGEAEVAEVAIREGRRYVRALSPVALPAPEAPPFRERGTYLVLGGAGGIGLTLSRTLARAASARLV LLGRRPLTPEIQRALDELHALGGEAVYLQADAADPGSMGRAVAAAKDRFGRIHGVVHSAIVMRDRSLVNM DEETFRAALEPKVRGSAVLFEAVRNEPLDFFLFFSSVQSFGGGAGQSNYAAASTFEDGFAHHLGTHLGVP VKVVNWGYWGSVGVAATPAYRERLARMGVQSIEPEAGMEALVRIMASSSPQVVVMRAAPEVLRQLGVVGQ GEEARKAAPAPAEPTAAREAKVQRRALAAAGEQAAAATPRERFVAYAKAIFAEVLQIPPGKIDPAATFET YGVDSIANLDLLRRFEVDLGPLAPTLLFEHLTVDALAAYFAERHAGALDQLGRPSSGETITRSDLFRSRG AVPERAPVAPSGAAAPATPSGAEATDERQSAAGTARPRGAAAGESPREAPAPARAGALPAAREDIAVIGA SGRYPGAPDLRRLWSNLEKGISSIREIPPDRWDFRPHFDPAEGKGGRSYSRWGGFLDEVRCFDGLLFNIS PKEAEGMDPQERLFLEVVWSLFEDAGYAHDALLRAAPKTGVFVGVMNRDYEWLGGYACARGKLTYAHSSF WSIANRVSYFFNLRGPSMAVDTACSSSLTALHLACESLRAGSCTSAVVGGVNLLLSPIHYARLTLVDMLS RDDRCKSFGADADGFVVGEGVGAVLLKPLSLALADGDRILAVLKGSAVNAGGKTGGYTVPNPNAQAELIT RALEEAQIDPATIGYVEAHGTGTVLGDPIEIAGLSRAFQSGTGAHGRCAVGSVKPNIGHLESAAGIAGLT KVLLQLEHRTLAPSLHAEPPNPRIDWASSPFSLQTRREPWTPIARDGEGTAWPRRASVSSFGAGGANAHV IVEEHRDERASEASSEPQLFLLSAKTEERLRAYVARWQAFLEEEVDEIEELVAPARRAAKGSPAAIRPQV LALIAGALSVSPADLDPDDDLSEYGLDQAGVGRVVDHLNAALGTDLTLHAASWCSSVNAFVAALTGGDAG ARVSQDEPAPPRLALDDAAFVLQTGRTPMAERLALVVSDFGELHAALGAYLAGRAPASLLRGRAGAKEGE TAGALDVQAMLRDRHLPALARVWVAGGEVDWHRLPRSREPRKVSLPTYPFAREPRWIPDAGPLVLPVGAA PPAAASREEASPGDPCFYYGFDWEPSPIAAERGAPLRGVTLSLEAGDGQGGRDLPGAVVRVRPGPAYREV HGGGFEIRIDAAGDYDRMVAALAASRRLPERIVHQWSLAGGAPAAAEEILTRGEALLDLGVHSLFHLLGA LARAGHRGLSRVLFAYPELDGPNPFLEAVAGYGPSLRHVFPELVFTVVRLEGTAARAAHGALADECRAAA AEVLYRGDLRLVRAIAPLRVPPPPDGAARRRDGVYLLTGGAGALASLVARHLARAGRPHLVLTGRSPDVR PALVAELEGLGATVSYRSVDVADRAGMARVIDEIRRRSGRLDGVIHAAGGTDATRIGDKPHRDFAAALRS KIQGTVVLDEVTQDEDLDFFALFSSTSAVLGDFGQCDYAVGNRFLDAYAQYRTRLCQSGRRRGRTLSVNW PLWREGGMHFDARGEQLYLRSTGMRYLEADEGLAAFDRLLASGAAQVMVLAGERAKIERLLGLTPPAAVA VAPAPAAVAPAQAAQDARAGAAAAERLTEVVRRMAAEIIGLEPERLGVDVNLGDVGFDSIDLKTFSARID DRLGVTVSPTVFFSHPDVRGLVDHLLATFPALSKAPDTTRDAATGGRSSAPRGEPAAPIAGSASATRAPG GGAQGDAIAIIGASGIFPRSRDLRAFWENLRDGVDLITEVPPERWDFRAYDGDPTEPGKTRSRWGGFIPD HDAFDPRFFNLSPAEAELMDPQHRLLLQAAWHAIEDAGYRASDLGGQPVGVFAGIQYDDYSRILQQSGAW GAQAATGNNLAMLANRVSFLLNLHGPSEVVTTACSSSLVAVHRAVHSLRLGESTLALAGGVTLMCSPEGV IGADQLGILSPDGRCKTFDRRADGFVKGEGVGVVLLKPLERAVLDGDRILAVIRATAVNHGGRAASLTAP NAQAQADLLVDAYARAGVSPETVTLIETHGTGTELGDPVEVDGLKLAFRRLAERQGLALPARPYCALGAV KTQIGHLEPAAGIAGLLKLVLSMQHRTLPGNLHLREPNPYLHLEGSPFYLPTETRPWSPLLDEHGDPVPR RAGVSSFGFGGTNAHVVLEEYPEPPPPPPRSGPRLLVLSARDEARLREYAQQLADRLEALSRDAAPSCDL SDVAYTLLVGREVMSSRLAVIAGSLGEAASAFRRFCRGDTPSGQVFHGRVDPSGRSAPSQVRRDTPLAQT GGGAPLARAGGDGVNLVDLAAAWVMGAPLPADVLFAGSRPRRVALPTYPFARERYWAGSAPRPPVEKAAP GPDLCQDLFYEPVWTPLRAPLAASFNGPTGASPAPARQDVLIVSTPAAEPLRRALAAAHAGDEVRSLGLG SGDGSDAPLEAVLAGLRPGALVYVLPFAGAEGAAGAAPTRAITAFFRLIKALFRRGFDVNPLKLKVVGNE TFHLEAGPVRSPLAAAFYGLAKVLARECEHWEIACLDLALGEESARPTAGSVAGSMTSSVASSVDRVRAF PWSRQGTLALLRDGVLYEQELVAVAVPPRAPPFRRGGVYFLVGGTGGVGHALSLHLAEAVGARLVWVGRR PLDREIERQIAAVEGRGGKVLYLQADVTDLAAMKAAVARAKAAFGRIDGVMHGAITLADGLLAGMTEERF TDCLAPKVEGSLVLGEVFAGEPLDFMTFSSAAAALFGNAGQGNYVAASWFEDAFALGLAARVAYPVQVID WGFWGLVGAANLPEVERRYAAQGVHPLTVPAAVEAFGRIVASPARQILVFRADSAALRRAGILRRREVYP ASAASVLEEPLVLPASESMAAEPSRAFDEALQQVDELARWDLLAAFQREGCFERRGAGCGRGALLRRLGV

VAPYDRLLDVLLQILARAGFVELRGDEVIATARVDSAEARERLRRLTDERERLCRTPPVGAHAALLSACV RDLFLVMAGHKSGAEVLFPGGSSELVSGVYQGNAAADHFNRLAAWAARAYVRRRSGAEPLAELRVLEVGA GTGSLSARALDAFAAEGVRVRYVYSDVSREFLRAGERRFGAAYPFLEFQVVDLERDVEAQGLTPGSFDLI LASNVLHATRNVHRTLERLKRLLKAHGVLLFNEVTRAETFLSLTFGLTAGWWHFEDGDRRLPGSPLLSPA GWRAALQTAGFRRLHLFGQAGIEPLEAPQCVVMAESDGVVVAPLAPLAPDSAHAEAQRVGRQGEAAQRAG RQGEVAQRADRSPGRSAGSDEAAARWIRDELRGVLARTLKLDPASVEDEVPLDALGVDSLVMMTLKRELS RDYPDLPATLFLEHSTLAELTGYFLEHQRSVVDQRCRDAEGVAPAALVHERAPAAAAPVIEESGARLAPE SAPDDIAILALDGRYPQARSPEELWENLRAGRECTREVPADRWDVSAYYDADPRRAAAGRMYCKWGGFLD DIGRFDALFFQISPTEAASLDPSERLFLEIAWSTLERAGYARRRPQSRSVGVFVGVNVGDYHLLALEEQA RGRWVFSNPSFSAIANRVSYFFDFQGPSLAIDTQCSSSLTAIHLACESLLRGECEMALAGGVNLYPHPSR YVNLCQVKALSSTGQTRSFGAGGDGFVPGEGVGAVLLKPLRQALLDRDPILAVIKGSALNHAGKTSGFMA PSPAAQADLLERALARANVDPGSVSYIEAQGMGSTLVDAAELAAFTRVLRRGRRQGPCLLGSIKPNIGHL EGAAGISQLTKVVHQLRSRQIAPSLHADPVNPEVGFDASLFRIPGALEPWPMPVVDGHAEPSTRRACISS FGAGGSGVYLIVEELDDPAARSAPVPMSAPQGEQLFVLSAMDEERLVAYAQRLLDVITSRDGAGDLSLRD LAFTLQTAREAMPWRLAVAAPDLDHLRADLQQFIRERRQTERTRWGRIRPAGAVLATSPSPTSPSPASAP LSASSAAALAHAWVAGAPVDWTALYEGGPPPQRLTLPTYPFGGARCWITQAPVSAPAPEAPPAVTDANGT AASPSTLRAPQRGTSLDAITTYLQGTIGDFLGLAGSLPADQALVDFGVGSIAMAKLCYHLEQRLRRPFPN AVLAQAGTIDSLAGMIERDPALAEIKAQVLRAQGAPGPGAPELAVGHDELWRLLGALGDAELDALGDAEL DALFNALRSRPELEGMV ChiD CY CY A PCP PCP OX (KS10) ACP KS11 KR ACP KS12 MQRPDRGRRLYRMEKAVTDAMFDERSREEKLSVFRALRDRLRRTPPQHGGAADGAGPRAPVLAPDPQNRH RPFPLMDIQEAYLVGKQLGDALGHVGGHFYMEIEEQDLDAARLERAWQRLVAHHEMLRAKILPEGRQQIM PPAPPVSLPVHDLRWSAAAEIERHRADVRLRLSHKLYEPGSWPLFDIEITRLPGDRSIIHFSLDTWVTDG AGLHLLQRQWFQLYREPGLELAGLDVSFRDVVLAIKEFEKTPRFREDLAYWLGKFADMPSGPKLPMRVRA GSPSATAASARVRLHRSLPPAAWGAMKSAARSSGVSPTTLLLTLFAETLSGWSGDEAYALVLTFFNRPPL HPRIDEIVGPFISTSLFKVEPPAGRSLIEQARLHQRQLWDDMDHYTVSGVRTLRELRLRSKADRASTLPV VFTSMLDNAAKPADAEDWFQRVSYAVTQTPQVALDHQILERDGALYLSWDYDAESFEPGVMEAMFDRYGR AVGELAEHPERWHAERPAADRPVAPSRSDAVPARAAPPPLAHDPALRHQSFGLTDLQQAYFVGRTAFLEH GGVSCQLYLEYECEGLDVPRLQRALRAVVATHDMLRAVIDADGRCRVLEDVPPYEIRSVDLRGDALPESA LATMRRRASEQVFPLGRWPLFEVAASRLDATRWRLHVAIDLLIADGNSVLLVLKQWFRLYERSEAPLRRP AITFQDYVAAVARLQRSPEGAVSREYWRHKLAHIPNGPVFPGARPPASVRSERARLQATLAAWPALADRA RALGVSPETVLVSAYVEVLSAWAEPGPFTVVVVDYERPPIHPEIDEVVGDFTFLRWLVHDPRSGRSFAEK VRRHQRGVEEDRAHQLLGGFGVLRDLALRRPEQGARVLPVVFTGFMPHADFRLPVGFCDACGLSQTPQVV LDTAQVEADGRLEYHWDAVQDHFPPGMVAEMFAAYGRLLEQLATSPEVWDRADLAAVLRERAPESAPSAL AGLTDEAWRERLARWNDTRAAYPEDQALHRLIEEQVLRTPDLPAVQIDGRSLSYRELDEQANRCARFLCA HGVVPDQIVGVLMQRSLELVVALVAILKAGGAYLPLEPTYPEQRLEFMARDAGVAVLLTQSSFSGVLAGF TGTRLCLDTEASRLSSYSADSPRVEVRPEHLAYVIYTSGSTGMPKGCMLSHRAICNRLHWMQEAYALTPL DRVLQKTPFTFDVSVWEFFWPLITGARIVLAAPGAERDPAALAGLIQEHGVTACHFVPSMLRLFLDEPRA AGCASLRHVFFSGEALPYPLMERALSTFSAQLHNLYGPTEAAVDVSFWKCNLRDDRKVPIGRPIANIRLY ILDEQQRPVRPDQTGELYIAGVGLARGYLNRPELTAERFVRDPFDPSPGARMYKTGDRAAWLPDGNIDFL GRMDGQIKLRGLRIELGEIEAALLGHEAVREAAVAVRDADSGDPRLVAYVVLRDGASFSPQVMRRFLESS LPRYMVPNQFVQVAGIPVTAHGKMDRAALPWPVQDDAAAAPPDAGAVKEKILRDIVALFELALGRKGLAP EADVFDLGATSLTLVRVSQKVREAFGVSLSVETILKHPTMAGIAASVAEQVAGAAAPQPAASPQPAASPR SAASPVKPAPEPVLPARPVQSARPAQSAPAASAKNGSPRVFAGQRLVDQLVGFFREAMNVAHVDPHQDLF DLGATSFTLVRIAQRLREQLDLSLSVDVLLKRPTVAGIAAFLEERGAPAAPVEAAAAPEPLAAPVEAEPS APAPQKTDFFSREQREAFKQQKPHLRRQGEHRGVIALPGDSVPEADYRLRSCRTDFQDQPIPLADFSGLL GLLRQATIDGKPKYLYPSAGATYAVQTYLHVKEGAVEGLGPGIYYHHPERHELWLIDGNPSIERTAHFYY NRPHFDRSGFSLFFIAQLDAIEPVYGASADPFVLIETGCLIELLTLRQSEFGVGLLPVGAVDFDRIRPHF GLGPRHVFLLNVLGGRVEREGALPRARQPGRGTPAREGVEALTVRGAPAGAFPVSASPGAGSRGAASAAW GTDIAIVGQSGRYPGAPDAAALWERLRRGERSIRPAPADRWDPAPLQATGPDKGGIYCSSGGFLDDVDRF DCLLFRMSPAEARSIDPQERLFLEAAWACLEAAGTTAERLNAQAGKVGVFVGVMWNDFQNEGVEGFREDH VARAVALHSSIANRVSHTFDFKGPSVAVDTSCSSAMTALHLACESIQRGECRAAIVGGVNLMTHPYHQGL LCSLGMVSESGFGNALGEDATGWIPGEGVGAVLIRPADDAERSGDHIHALIKATAINHTGATPRYGMPSA EAQAASIRDVLRRAGLGPEAVSYVEAAATGAAIADASEIAALIEVFGERQGSAPRVALGSIKPNIGHLES ASAMSQLAKVLLQIQHKTLAPHVLSGALNPMIPWDRAPFWVPEQPAAWQPRSGPRRALVNAFGATGSLGH AVIEEYCAAERPAEASIGPYGVILSAATGDQLREYARRLQGFLAGPGATLSLAGVAYTLQVGRRDMAERL AIIARDLDDLGAKLAAFAAGQAPLPEGVFTGSVDGTPVPRPAAASDDPVALARRWVAGDAVDWSRCYRRP PRRVPLPTYPFGGQRLRVREISRASGAAPAPAAAPAPAPALAAAPAVAAAFAAAPAPAPALAAAPAVAAA FAAAPAPAPVTPAGSQAEDGLLDAVERWLVQLFASVAEIPARDVRAKTPLSDYGLNSLMAMGLYRLLSAE GLAGLPKTLFFQHRDLREVARHLVTSHGQALRQRFGLTGAEPSGAAAAPAPVAGVAVVAPGPLPAAVGDD TAIAIIGVAGRYPGADDLREFWQNLREGKDCITEIPADRWDHAAWYDPDRSKLGRIHNKWGGFLRGIDLF DPMFFRISPREAEFMDPQERLFLEVAWSTFEDAGYTRELLQRRHGGCVGVFAGVMYSEYPFYGVEATLRG RPVAVGLGYGSIANRVSFVMDLNGPSLSVDTLCSSSLTCLHLAVESLRRGECAMALAGGVNLSLHPNKYL

QHSLFKMTAPDGRCRSFGEGGDGFTPGEGVGCVLLKPLSHALRDGDPIHGVIRGVAVNHGGRSSGYTVPS AKAQAALVKAAVARAGIPARSIGYIEAHGTGTPLGDPIELEGLNQAFQGAAEPGFSCPIGSLKSNMGHLE AAAGVAGLTKVLLQMKHGELAPSLHAEALNPNIDWTATPFFVQRRPAPWERATVEVDGRSQVLPRRAGIS SFGAGGANAHVIVEEAPEVAPRPPHEGPQIVVLSAREEGRLRAVAARIAAFLRGGDDVDLADLAYTLQVG REPMEERLALIAGDREALARGLEAFAAGDDAAVLRGRARSDDRALLPGDDEGVRSLIAQWIGKGRLQQVA RLWVSGADIDWEALPRPSACRRISLPTYPFARERYWLPLQDEPAGAAGVAAAPSPSADLGGERGAAAPEA APAHAGVFLEKAWRPSERVAGGAERPDGAVLVVAGRQTLALAEALGAGHGDVRVVLTRDAAAGFHGGEME LDTGAPAQADALAQALWNEHGGIAALIDLSDIHREPVARCPLQLGKLAFVQRLVRLAVPGPFRLLHATRG RLPFRNEAPSLAGAALAGLIGALGAEYRSVRARTVDLDERALSGASLGELLWHEFMANAPEGEACYRDGE RFVPRISPVSSSGGPRGGDPIASAIAAGRPILVSGGMQGLGAEVARHLVRRGARRLALLGRKPLPPRERW RALVADPARDPLTAARVALVLDLEASGAEVRIYVGSLTDREALQGFLGGLERDLGPLGGVVHCAGEMRTS TPAFIHKDIADIAAVLSPKVDGLQLVHELTSTSPLDFFVTFSSVAALIPRLSAGILDYAAANAFMDVFAA QRAAAGERHVRSIQWSRWQGGGMAGEGTRRFEEWDLPTYSTAEGLSLLDQAVRLHGAPCVFAGRKLPEEA AAERWLQVERPEPVQAKQPTLGAAPPAPAARAGENGASHIAPRAGENGASHIAPRAGENGASHITPRVGE NGASRVLDGLRGVFSAELRIPVAKLGSDTPFEDFGVDSVILAGLVQRIETWLGGVALEPTVLLQHRTLDD LARHLRKHFEAEIRARLSPRPAPADNVPAQAQAQAVAASDAPRRDATAQSAHAPAEPVAAPAPAPAEPAA TIAPAPDAGARASLGASSSGQPRIAVIGLACRFPGAPSPAAFWENLAAGVCSIREVPLSRWDWRRLYSPA LQEGKSISRWGGFVDDIEGFDPGYFNLPESDAVMLDPLVRLFLEAGVTAFLDAGYDRKALGGRKVGVFVG ARSANFAERSRHASKASIVSGGQNFIAAHLSHALNLKGPSLVVDTACSSALVGISLACQSLASDACEMAV AGGVDVLLDEKPYLVLSAGRALSPDGKCHVFDEKANGFVPGEGAGAVILKRLDRALADGDRIEAVIEGIA VNNDGRTMGISTPNPEAQSAVIEEALSRAGAAAETLGYVEAHGTGTLIGDPIELRGLTQVFRRSTEERGF CAVGSVKTNIGHLLSAAGIASFIKVVLALRHRQIPPTLHCETPNPRFAFADSPFYPATRLAPWRPRRGVR RAGISSFGFGGTNAHAIVAELDPALAPSDQQGRRRLPSPVFNRRRFWPESPAAPSSPQATAAPARRDPTR FQLEFEPADGAEPDARQPGRR ChiE DH ACP KR KS13 KR MT ACP KS14 DH KR MT ACP MNPFRCHLTVHHDNLMLRDHRVHGTRLLPGAAWIEVLSKVLRERGFPIYRMAFRDLLFRTPVAPGADAPK RVLVTVDRADGGWLVVVQSRDAGAEDTSGAWTDNLSCHLVEDTSPFGKTIDIAALQRGARRRVDLEEIYS ATRRMEIVHDDFMKVRGHVDEGEDYLLAFFELGSLGKEYLDEYHLHPAFLDSALVFPPYFIVPPGQTTEV PFIPFHVDVFRAVDRLGGSCFVHMKKQELRSSSQHVSYGDIELYDPSGRQVAAYGRFSAKRVRFKQLIQQ LAPSAEAAPAKDGPGASSPTTAAAGAAAGFDAAPPAGGGEASAGGKPAAPVGHEATRSAAAQAPAQGGPD AAPGVRGAIVAELRAMLGGIHGEGAEEVPLDVGFYEQGLDSADLLRLVRTLEKRLQTQLYPTLLFEHTTV ADLAAYLASHHADRFARPAMPPDRAPPPDRAPPPPRPAEVVFARPAWGPAPAAAADLRPGAFWIFDTGTE TRDALIARRERDGHPAGPVVLVRPGARFREISPDTFEVDPRSPDDFHALVHGLEARSGLPSRILFLWGQD PFAGDDEAIARGLERGIHAALWLAQALCACSPAEPVEAVLAYVERDDGDHAHLAALGGFARTLSRENPRL RFRTLAIDPACGGGAARLLDAILPSFGRGDDALELRYEGGRHWARRWRTWTPPAAAGGPARPGGVYLITG GTGKLGLLFARLLAGEPGVKLALVGRSPLGEAQAAALRALAAQGAEAVYLQADLSRRREVVDLVAAIKAR FGRLDGVIHAAGLIRDALIPSKTKEAVQAVLGPKVLGTLALDWATRDEPLDFFVSFSSTSAVWGNAGQSD YAYANAFLDHHAAHRELLRQRGQRSGRSLSINWPLWRDGGMQVDADAEAALAEQTGIVPLDTPSGLRAFQ VALGAGLTRLLVVAGEAERLQRILSLDPAEDEPPAAAASAASGRAPGAQPTGAPGLPPAASGVEVPPGAT GDIAIVGLAGFYPQSEDLHAFWRHLAEAHDLVIEIPGERWDYRSHFDPEERRQGTSPCKWGSFLERFDQF DPLFFNISPREAEILDPQERLFLQAAYHAIEDAGHGGDRLAAERVAVFAGVMWGQYQLFSAGVGPGQPGP TLGSLYASVANRVSYFFNFAGPSVSLDTMCSSSLTAIHLACQAIRAGDCTAAIAGGVNLSLHPNKYTFLS QGNLLSDEGRCRTFGEGGTGYVPGEGVGAVVLKPLARAVADEDWIYAVIKGTAVNHGGRASGFTVPSPKA QGDCIEEALRKAGVAARSISYIEAHGTGTALGDPIEIAGLSRAYRKGTADRQYCAIGSAKSNLGHLEAAA AIAGVTKVLLQMHYRQLAPSLHADPPNPNIDFEGSPFRVQARLAPWQRPVLEEGGARRTVPRRAGVSSFG AGGSNAHVILEEHDNRVTPDDGRPRVFALSARDEERLDDYVRRFIDLLERRGSGALPAGAANGAANGAAN GDGVLAAAQAALRDVVAELLSVRAEEIELDVALSSYGFEPVHAVRLAERLRERHRIEIQPDLVVGLTDVK ALSSHLAATHPERFSASRGALPQGGAGEAEGPPRLSLADLTYTLQVGRAAMPARLALVVRSLDELLEALK DTREGKAREGLHRGAAKRPHALAAPLIEGRSGRTFLQCIVEDREYDKLAWLWTAGIDVDWRLLYEREPVR PRRVPLPVYPFAPRRYWAPSREVAAVQQARPAPHMPAPQVAALPAPQLAAVEAGAVGGAAPAFAAEAAAA PNTLFLARWEPVTAVSGAPRPGAERVLIVVSEGGERLAEAIRRAHPRDEIRALWLTGDGDGRGVPAEGRS VSVGDAGALERALQDLLPAERAYFLAGKPGRAGDDLDEEALDRSVARGLLAFFRTIKALGEQSGPAPRLA LVTERAHAVLPGELAHPPSAALHGLAGVVAKELPRLLVQGVDMDGETLEADALAIHQALGGAATDAHDRA FRGGRCYRRVLRPIALPPAASSPFRRSGVYCIVGGAGRIGMDLSLFLAASAGARLVWIGRRPLDAALRGR MDRVSAAGGEVLYLQADARSQRQLAAALGEVRARWGRIDGVFHAAFLFASEPLAAMSPERFLELLGAKLW GSRALAAALAEHAPGFLVFFSSIQSSSRDKGQAAYAAGSVFQDALGASLARSAGYPVKVVNWGYWDDGDA LGRQRLAALGYGAIAPGQGLAALERLLAERAAQLAVVPADEHVLRALGVAGDRSLELLPESSPPLLARLA PALEDEGRRAELPDLGPAFSALDAFGKRALAAVLRDMGLSRGPGARASAVEARDRLGIAPPHHRLFSALL ALLDEAEQARSDAGPAAPLARTAGSLAALEGERDRLMEAHPEARAHVQLLWECLRHYPAILTGRVAATDV LFPDGSMALVEGIYRGNGAADLFNRMVAKSAAAFVRERLGEAPGERVSILEIGAGTGGTSAGVLAELQPF GSRVRYVYTDVSKAFCLHGKRAYGERYPFVEFRVLDIEKDVEEQGFPAGQFDLVLAANVLHATRDIAKTL GRAKTLLKARGWLVANEGTGVQGFLTMTFGLLEGWWAFEDEAERLPHAPLLDGSAWRRLLEQAGFSPVLP LGYVGPGGDVVPQQVLVAESDGIVARGPSHGAAAAVRPASADEAASARRESVAAADPGDVPARKDAPAPR

RPVDGHEVEARVTACVAATLDLPVASIDPSAPFAEYGVDSILGVDLVRLLNEAFDVKLRTTVIFDWTSVR ALARFLVETHGDALRPAASPREAAPPREAAPPPPALSSAAAPRDQAPAAARSRRIAVIGLSGRFPGSPDL DAFWDNLAAGRDCITEVPKDRWDPDRIGGSAAQFRWGGFLDDIDKFDPLFFKISGREAELSDPQQRLFLE EAWKALEGAGYTPEALDRARCGVYAGALDGNYQAFMSPKDLDEPQTLWANDTSVIAARIAYFLNLKGPAI TINGACSSSLIAIHMACQALWSGEVDLMLAGGVCLMTSHHFHEVAGKAGMLSPSGRCRTFDDGADGFVPG EGVGVVLLKRLDDALRDGDPIRAVIAGSGVNQDGRTNGITAPSALSQAELEARIYRDFDVHPESITLVEA HGTGTRLGDPIEVNALTDAFRTLTSKTGYCAIGSVKTNIGHTALASGVAGFIKAVLAMERGQIPPSLHFR GANEHIDFANSPFFVNTELRPWRPSGPRRAAISSFGMSGTNAHVVLEEPPARPRAAPSTAAPAFLIALSG RTRAALEQRVRELLRWLEGAGAAEVLGDIAYTLLVGRAHFDVRAAFAAASREELTERLRAVIRGETDGGV VFGELGAKPARPEPALRELASVLLGELRRAPSGDAGGAGGAYRSKLLALADLYTRGHDPDWRALFPEDTW RRLVMPVYPFARARYWLSPEPVEREAPARLHPLVDGVDLAESLGAGLTFRKTFYPGDRVVRDHRVHDAAV LPGVGFLEMASAAASRLLPGGRASLRRVFWLNRLEVTGPVDVRIRVYPEREHHRFQIASGGDEPTVFAEG ELHPAAPAPEASGERLALQDIQARCAELADGEQFYRGLEGSILRYGPYFRVIKRVWASREEALALLELDG AFRGELDRYGLHPALMDGALQTAMALSASHGGEGQAIALPYTVERVDVLRPLGARLYAHVRQAEKDRYKV SLLDASGAVCVELQGLVVRAPRDPLGRLFFRPRWVSEPAEEARDAAGPGAVLVFAPPSWGDAAQPIAAVH PDRRVVLVTLSRETRLSGVDRLEVDRRDPEAFAACLRANAPIAGIYFLGGLQAGPAALDDLEALERSQES GVFAAFHLLKAILALRPAPEGMFFKVVVDRVHPVRAGERVAPHGGDLVGFCRSAAKELSGVRIGVVDVVD VDAAELRRDGEALRAGALWWAIARGPGAPGGVVAYRDGVRSVPILEPVALPPAPRAPFKRSGVYLIAGGT GGIGIELARYLAEHFAARLVLLGRKPPSAVAAQQIEEIRALGGEVLQLQADIADEQSMRAAVARARERFG RIDGAIHAAMVLADRTLMTMDAETLRSVLRPKVRGSVVLCRALRDEPLDLLMFFSAGQSFLCNAGQSNYA AGCVFKDAFALALHQQTGVPVRIINWGFWGSVGAVANEEVRQRLSALGVHPIHTHEGLEAVVRVAASPLE QVLAFKAEPGFLQAMGVRWERRYQAFAPAAPSLIEAALDRLEPPSIDARALELSGEASRALQAFGARALL RALQGMGALRRAGDRRQVSALREGLQIAPHYHRLFDALLGIVERAGWARVDGETVTAAADLPDALHAWDQ EQATRRLLQEHPGLEDMLRFLSACLSAYGEVLTGRRGHMDVLFPGGTTSLVENIYKGSPVVDHYNRWVAL VVARYCRLRLAEDPTAVVRVLEVGAGTGGTTAFVLEALASFGDRVQLVFTDISAAFVRQGERTFGDRHPA AEFKVLDLEKDPEAQGFRSNDVDVVFGTNVFHATRQIERTAGWSKRLLRPGGLLILNEVTRVQEYPTLTF GLTPGWWHFEDEPLRMKGSPLLSIAGWREVLGRLGFRGFRALGLPGVALEAQDQAVLVVESDGVVELDAG SPAPTARAAHAAVPPERPERAREVREINGAARDHEVRASEPVNGHAREQGNGHGAEGRPARQRAAVAAQP PAKARQDRAALLESTRTYVKGIFSDVLKIDPESIQDHRNFDAYGVDSLVVLNVTKRFEQRVGALPSTLLF EKLTVEDLAVFFVDHHEAALRASEPPGVGGGGAEPVRPRANPERPERADPPERAGVAPGRRAPSPPAAAV ERFDGAVPEDLAGEVARMSDAEVERLLGWLQGGGAGGAGGAGGAGATNGSSAVRASLDDGQEREAERRRL DRGPSGEWR ChiF KS15 KR ACP KS16 DH ACP KR KS17 DH KR MT ACP (KS18) ACP TE MTLRSQDLMMDAKRESLVRLLHQKKANRDIAVIGLSGRYPRSPTLEVFWDNLRHGRSCIDEIPRDRWRWE DHYDPDPGVGGKHYTRWGGFIEDVDKFDPLFFRVTAKDAENMDPQERLFLETSWACLEDGGYTTESLARH AFKVGVFVGVMNCNYEWLSAASCARGRMTGAQSAYWSIANRVSFFLNLQGPSLAVDTACSASMTAIHLAC ESLRRGECEAAVAGGVNLILHPMHYLRLTHMRMLSPDEKCKSFGAGANGFVDGEGVGAVLLKPLVRALTD GDRIYGVIKGSSINAGGRTNGYTVPNPNAQADLILAALASTGIDPRTIGYVEAHGTGTSLGDPIEIAGLT SAYRRYTDGNGYCAIGSVKSNIGHLEAAAGIAGLTKVLLQLQNKQLVPSLHSERLNEKIGFADSPFYVQR ELSPWPEGTSLGAGDPPLRRAGVSSFGAGGANAHVLVEEFVDPRPRDERRDGAPVVVVLSARSRDRLEAH AGNLKAFLERRGDEAGEAPALSDIAHTLQVGREPMEERLAFVAASRRELVDKLDRFARRGTDGLFQGRAG KAPARALPDGAGSGGAGAGRLEEIARHWAEGGDVPWRQLAVSPAGRLISLPSYPFARESYWLPGGPGVAG EFLKPALAPAPAHPVAEVAPTDGRGPVLDTAAGRRATFLYKRWREQARPSSSLPEVAGSVVVLADAATHP VAERLFRGDRSLQKIVLRTDAPGSGAGAWFRPDSAGQGAEAAERLLGAHPDLAGLIDLSDLSDLDPALDL DGGASAGKMAFLQRLLVAKRTAFRVLHFTSGLVAFRADRGSLSGASFAGLVRALGAEYRGVVARTVDVDR AAARADVLPSLVESEWSLPPEEGEACYRGGVRHQPYLSERGADGGAGAAPSPAGAWSPDKVWVVTGGTRG IGAEVARHLVERGVKRLVVMGLRPLSDGGRATGPSAGSDAERRIQALEQRGASVRTYTGPLTDRPRLERF FGQVRAEWGPIGGVIHCAGLADHERPAFIDKSAASIARVLEPKVAGLAVLHEIFERDGLERFVLFSSVSA LVPALAVGAADYAAANAFMDGFAAHQHALGRHVYRSLAWPAWGETGMGDPRSPRLSRLGLAPLTTAEGLA LLDAALAREAEPTGMPCVLVEGTIPMERWLRVDAAAEQPVPAAAEQPAAAGGAQRPERVDAALLAFLRGI VSQATGIAEVRLDPETSFTDFGIDSILLLDLVKKAERHIGASLDPSVFLEHPTLARLSAYLGERYPGAAQ PASAAVSAPAAEPASQPVSAPSARDVVPFVESAHRFSTSGTAVPRPAIAVIGVACHFPQSPDKETFWRNL ESGADLISEVPPSRWDSERYYDATRSPGRTISKWGGFIDGIELFDPEYFRMTPESAPFVDPLIRKALEVG VTCLRDAGYEQRELAGQQVGVFMGARTANFTDKITMPAKNGIPGVAQNFVAALLAHFLDLKGPNLVVDTA CSSSLVGIHLACQSLLCGESTMALAGGVDILLDEKPFVSLSEAGALSPDGRCHVFDERANGFVPGEGCGA VLLKALDRALADGDRIYAVIEGSAVNNDGRTMGVTTPNPDAQGQVIEQALARAGAGADTVSYVEAHGTGT MIGDPIELRALTRVFRKSSQDRGFCAVGSVKSNMGHLLSAAGIASFIKVVLSLWHRRIPPTLHCSAPNPR FEFASSPFYPNTALQDWLPRSGVRRAGISSFGFGGTNAHVIVGELPAGTATRERRQPLAAPAFDRRRFWP DGGADDRAARERPLLALRRVDLGGDDRIRFETSMNNDDYIVRDHRVHGVRIMPGVTFLDLIYRAAESAGL QRDGLELRHILFKNALATGAAFDRQIRVDLERRGGFWRATAASRKARDGRALADEWEDNFECEIHRAEAD APPPLDIDRLRRQAAQSLDVDDAYAVARAMEIQHFEFMKGRGRIHRGDGFVLAELHLGELASRHRRDFHV HPAFLDCSTLVPAKLDPSAPSATKPCIPIYLEAFRAFRGSGERCHVLFRGQDARRPASEDIFHIDIDLFD EAGNPLAWFRNLSIKRIRSQASLTRLDLADGAAAAATGTVAPRVAPSPAPAPAAGRVADAAAPRESAAAP

AARPALSRALVERELIDMVASASGRPADEISLEDGFYDQGLESTNLLQMVRDLERRLGKRLYPTLLFEYK SVRELTDHLLEHHAGAWVSALSSDTTGKPEPAPGPDPAAHAPAQLLAFAPTWEDAPLSPGARAGAPARIL LVSDDEALARALASRGQAVTQVSLGAAFRALGADRYEIRAASAEDCQLLLDALAARGDVPGHILHGCRPA GSLEDGLARGLHTVLPLTQALLARGPAGRITLLHAHLDRGGRPAAWDAAFGGFARSVRLESPRAVYKSIG LPEDLASAADLLLAELIEAPDDVEVRYHGGKRQVRRLREIELPGDAPAGLPLRQGGVHLITGGMGGIGWR FAEHLVDRARARLVLCGRSPLDADKQRRHDALRARGAEVLYVVADVSRREDVARVIELARARFGELHGVI HAAGVLRDALIPRKTREHVDAVLGPKVHGGAHLDALTRSEPLDLFVAFSSSAGITGNAGQCDYAFANRFL DQLVEGRAASGAHGRSLSVAWPLWAEGGMRVDAATEQALWQATGMKALSTAAGIAAFERGLRARTAVMMV AEGSAERLRAFLAPGQPPAPHRGAPETWTDAGHAGPARPENGLSARLPAAVAAPADDIAVIGVSGRYPMA DDLDAFWENLAAGRDCITEVPADRFPVDAYYDPEVGKLGKTYTRWGGFLSDVDRFDPLVFNIAPREAELM DPQERLFLETAWATLENAGYARGALAKRRVGVFAGVMWGQYQLLGAERAGRSTVLPASIFASIANRVSYC FDWRGPSLAVDTMCSSSLTAIHLACESIRRGECEMALAGGVNVTVHPMKYLYLSQGRMVSTDGRCRGFGQ GGDGYVPGEGVGAVLLKPLSRALEDGDHIHAVIKGTAINHGGRSSGYTVPNPEAHGALIRDALSAAGFEP ESVSYVEAHGTGTSLGDPIEMTGLAAAFPGLPARSRALGTVKSNIGHLEAAAGIAALTKVLLQLEHRQLA PSLHADPPNPNIDFDASPFHVQRELAAWQPPEVPGQQGRARYPRRAGISSFGAGGNNVHVLLEEHAPEAD GPGEPAPRAQLVILSARKPAQLAELAGRLLDFVRRPAGDSAAGNGAAQGGAAAERAIEDALIEILTEPLG VRAADVDPELELEELGVDPPALVRVGQQIRERFHRDLDPDVLSRSSVRGLARSLAERSEGAAVRGSAVVR GAVRGRLTDLAYTLQVGREPMAERLALVVSTAAELEEKLAAFCRDPGAASGVFRGRAAGRHGPARSGVEQ ESLPALAEGGRLDRIAALWVAGADIDWKALFPERKARRVPLPTYPFARERYWLADLDPAELAREKEPARE HPLLARLDGASSLGQGLTFRGGLGADAPLLTDHRVASRAILPGVAHLEMAFAAARHIWGAQRVALAKVYW VRPAALEGARLDLRLAVREEDGAAMFEVLGGDPAAPVLHAKGKLVLDGASSDAEEGEMVEAIESIQTRCR DRVEGEALYARYRQMGMDYGPHCRAVEQVWVGDGEALAALALPASAAAELDRYHLHPVLMDSALHAALAL VSGEGQSSSPVMPFSVERVELLRPPGARMFAHLRGDGAQTFQMTLLDASGRVSARVHGLASRPLPRPTQP LPRATQPLPRATQTLPHPTQPLPRPARPFYFLPAWQSAPLPPPQGRRVDVQRGASAGPATIIVHHPSAAA LKDALVQAHGGARVIEIELGMAARPRGDGRWTVNVEDTASFEPCLRSVSQLDTVYFLGEARGGVAADLAA SRRSAAHGVSALFRFYKALSLHPAFREPFSLKTVGVQAIPLHRDDAVSPLGAALYGLTKVIAKEHPSIRV CCLDIDGAPLREGASPGELQDVAQAILAEPCSARAQEVLIRAGARYTRRLVPLDLPASEPPFRERGVYLI IGGSGRIGLAFARHLATRVRARVALVGRRELDDAMRRELAAIEALGGEALYLRADVADLESMRRTVGEVR ARFGAIHGVVHSALVLHQRSLAELDEATFARELSPKIDGSGIVDALFAGEPLDFMVFFSSASAFQVNAKQ AGYAAGSVFTDAAAHHLARQRPYPVKTINWGYWRSVGDVSPELVQRLEMAGVEPIGDEDGMAAIEAILAS RQIQVAAIKASAAVLAHVGVDSTRRLLEQAEPAPSVLEAIARRGLQPPLDAGAIERCRAAIEALGASARR ALAEMFRWMGVFLAIGERWTEPALRARLGVVSAHERLFHALLRMLCEGGYLERAGDDYVVRALAEPVAPV SGGGAALAARHPEAAPSIELVWDRLAEYPAVLTGRKQATEVLFPRGSMDRVERIYQGNAVTDFHNRLVAE VVVAYVEERLAREPGPAIHIVEVGAGTGGTSALVLDALARLGARVHYAYTDCSSHLVRHGEKVFAPAYPF ARFAALDIEAEPGPQGFEPGSVDIVLATNVLHATRRIEHTLGRVRALLRANGLLVLNEATRTQDFATLTF GLTEGWWLFEDAPLRLPSSPLLSTARWSDLLGVSGFRGIQRHGLPGVAVEDMAQCVFVAESDGLVTVAGD QGAAARGDRAAANGAEARAPAANGAAARAPAARRDVTPAADAAPPPVRLAALAAVAPAPERSARELQERC EEYVKGVIARVLKIAGSELDRDAGFDAYGVDSLLAMELADAFAKDLGDMPSTLVFERRTVAEVATYLLES HEEALRRTLGLAPRASAAAVAEVDGDVGAEVAAGRSEDIAPVSSQRRRESAPDLVRPGAASGGEFAIIGI GGRYPEAADVREFWENLKAGRSCIGEVPPHRWDGDAYYRPDGGGASRSKWGGFLEDVDRFDPLLFNISPL EAERLDPQLRLFLQTAWETFEDAGYPRRRLRVVQQGATSGVGVFVGSMYQHYPFVAPDGATAAQLSSFPG SAIANRVSHYFDLKGPSMLVDTACSSSLTAIYMACESLARGECAMALAGGVNLSLHPQKYVIFSQMGLLG SKERSSSLGEGDGITVGEGVGALLLKPLALALRDGDRVYAVIKGGFVNHGGRTHGATVPNPSAQADLIVE AFRRAGVRPDAVSYIEVAANGSPLGDSIEIAGLKQAFRRFTVERGFCALGSVKSSIGHLEAASGVSQVTK VAYQLHHRTLVPTLNSEPLNPNIRLDDSPFYVQRERAPWRPAVEGEPLRAAVASFGAGGANAYLILESFA GAEVAPRPDPRQPCVVVLSGRDEDRLKAYAERIGSFLEASPETPLDAVAYTLQIGREPLGARLALIATDA ASAAAKLRAFARGEEGIDDLARGDVGTTPAASRLLLDGREGEAYLRIVIEERKLRKLAQLWVSGVDVDWP LLYPEGTPPLMYLPAYPFEQRACWIGQGEAPFWSQPSQQTRRGNGEAEEHAEPPPRLNGTNGAHADRLVE DLGALVAQSLKLPPYALSPDRELSLYGVDSITGAMLAGRVKSVFGVDVPVPASGGASTLRQWAEQLRQRG GKRSLPDVMPLEPELIPMNPAGTRPASFWCHGALGFGQIFRPLSAALGEDYPVYALQARGVDGTRLPFHR LEDMLTHYVACIRSVQPRGPYCIGGYSSGGILALELARELHRQGETVARVILLDTYPSTPEVQRWFAGFM DDDYLHVAVAAMLFAPGRADGLVSVEELQGTPPEVRLGHLASLLAERLGAGWSRDEIYILLQGAVNVARY TGQALHGYEPSRYNASDVLYFRAAAGFVDPGRAGSGLTRGVGPDAPDHVAPWRDIVASRLDVVSVPADHF SLLSGPGLAVIKEHLVRLFEPLRILEGAARPGPSSPAQIVPRTEQDLPAIIEQEGG Difficidin DifF ACP KS1 DH KR MT ACP ACP KS2 DH KR ACP KS3 MSTEKFFCTRDGILMKCINEFLRTVIAEKLGAEVTEAEDKTAFFTLGVTSLISEEIMTILHKEFTGLSETLLFEYPNIEKL SEFLSAQKRNPESVLEFKETEPDTGSRQEEELLPVQAAEKVLRETDGSSDIAVIGMSGMFPKAENQHDFWNNLMENKDCV SEIPEDRWDSSYYSEEKTAEYASYSKWGGFIDHPDQFDPLFFSVSPWEADLMDPQQKLYVTCCWEAMEDAGYGNPAARPT DQIGVFAGVTWNEYSLIAHEEGFLKDQYKGPGSLYWGIPNRVSYFLDLHGPSIAVDTACSSSLVAVHQACQAIMSGDCEM ALAGGVNLSLHPQKYMFLSQSHFLSSEGKCRSFGEGGDGYVPGEGAGAVLLKPLKKAIADKDHIYGVIKGSATNHGGKTT GYTVPNPEAHRDLILSALNRAAVSPADISYIEAHGTGTALGDPIEIRGLSMAFDKQTDEKNYCGIGSVKSNIGHLEAAAG IAGLIKVLLSMKYETLPASLHSEELNRKISFSDSPFYVVRNNRPWPAEGDKPRIAAISSFGAGGSNAHLIVGAYHPKRQA DKNTEQKPHAVVLSAHSEQQLKEYAGKLSSFLARLENLPSAGGYSLENIAATLLSGREPFSFRLAVIASSLSKLKQRLDG FVSGHSDGRYMYFGKASHGRSDVSGQSVSDPEKFAALWVKGLQGCKKPETPYQKVPLPTYPFLKETSWLTDQKKRYTKKP

QNIKRREALHPLLDKNISSARKGTFQKIFSKDEYFFKDHLVNEKYVLPGVCHLEMAAYGAGLWGERPVVSLQSVWYMEPI VTGTDPRSVMIEFEAEKERISYVIKEKGADGTLFSQGEVICKEKGASFEAPAFQLPAPFVQRTEPEDIYHSFSEAGIVQK DSFQVIREFSYTERKALAKLTLPSHLEADFKQYILHPSLMDGAVQTAMAHVLQFQKEPALIVPFSFGEIQLLEPLAKTVF VHAEVKAASVHQFDLHICDERGVLLAAVKDFIIKEVQESAGFNQKAGVTPKKSRETELLMTPVWNTVTIPETGMSFMREE KIIVIGAGPDFQQALKEMYSDVRFPDITSLDSAEQMAETLKAQGSFQHMIWAAPDHPIPSVYDADTADGQEHGVMQLFRL VKALLLLNFDTEQLSLTICTFQAQPIHEHDEVNPSHASIHGLAGSLAKEYSNWSIRLLDLESQRGNRHLPDVFSLPADLE GNPWVFRAGQWHRQQLAVCRPHADEPSLYRHGGVYVIIGGAGGIGEVWTEYMIQTYQAKIIWIGRRKKDTQIERKLKRLA ALGPAPQYFSADAADYDSLKRAYDTIVKENGKVRGIIHSAIVLSDRSFANMEEEQFRASLSAKTDVSLQIARVAEGEPLD FLLFFSSMMSFQKAPGQSNYAAGCTFKDAFAKRISQKAPYAVKVVNWGFWGSVGVVASEQYRKRMERDGIASIEAPEAMK TLETLLSGPHDQLALIKTTDPVFMKDDLKEQVTVYPEKIPSALGQLTVNITQNDEAERLKASSVMSCMREMESLIEKMLV STLYEMGAGLDQALPLFQSAAGITEQYSRWLKESFVLLTELALAPEKTDLGQMWEEWERKKETWLRQKDMRAHVRLAEET LRVLPDILTGKLPATEVMFPDSSFRLVEGIYRNNIISDFFNDKLADTLIAVLKERLEKDPQAKIRILEIGAGTGGTSAAV MRKLKPYEAHIAEYCFTDISKAFLLHAEDIFGPEYPYVTYKIFNAEQPVSAEASDIGTYDAVIATNVLHATKNIRSALRH AKAMLQKNGQLFINEINSRTIFNHVTFGLLEGWWLYEDHDLRIPGCPGVEPAGWAEALSLEGFVHPLFPAEAAHDLGQQI IAAESDGTVRLALPQASEEKPERRPYDADGLSDDTLHVSLREKSVELLKKVIGEALKVPAHRLLAHEPLTAYGLDSILVV RLTNALKDVFGSVSSTLFFEYQTIDELADYFLSSRKEALERQFGNGRAHPENAGRVQAPAESAAPIPNVRERGITYLTEL IGKTLKIPSGRMDPSVSLTAYGLDSILVVRLTNAFRNVFDQMTSTLFFEYQTIEEIADYLLLSQRGAFMKAMGVREAQLS DHTDNLNVKQNKIPQNEEGERTNGDPYIRDIAVIGLSGRYPGADHVDELWENVKAGRHSITEVPKDRWDWKTFYNEERGK WGSIYSKWGGFLEDIDKFDPLFFRISPAEAERMDPQERVFLQTAYSSIEDAGYTPATLCDSRKIGVFVGVMNSNYPTVPS DWSIANRVSFLFNFQGPSMAVDTACSSSLTAVHLAAESLRSGMSETAIAGGVNLIVDPAHYERLSAFSMLSPGEKCKSFG DSADGFVDGEGVGAIVLKPLAQAEKDGDHIYGVIKGSMLNAAGRTNAYMVPNPKAQFDLIAETLKRTDIHPRTVSYLEAH GTGTALGDPIEIDGLTKAFRLTTEDRQFCSIGSIKSNIGHLESAAGIAGITKLLLQLKHKRIAPSLHAAELNPNIEFEHT PFFVQQKETEWKRPVLNITGEMKEYPRIAGISSFGAGGSNAHVIIQEYVPSDSLKPMENVLVSPQKPAVIILSARNEQQL TERARQLLDDVIRKERSDGDLAKIAYTLQTGREPMAERLAFTAESIEELKMKLMSFSNDHSIEHAHIWRGRTAKHHSLAA SLTSDEDMALTINAWLKKGKYGKLLDLWVKGLDVDWSALYQRNPGRISLPAYPFAKDRYWVTKADVSLDKTGSSKSEKAA RLHPLLHANTSTFTAQRFTSVFSGHEPFFADHIVNGKPVLPGAAALEMARAAVTLAAEDLPGGKTGVRLKQIVWLRPVTA LSEGVTLHVKLQPEENGDIAFEAYAEGEEPLVFFQGKAVLEETERAPVLDVEAVQARCGGRHLSKAECYKAFDSLGITYG PSHQALDAVYAGNGEVLAKLTLPPSAREEKEPFILHPSMLDAALQASIGLVLSDGSASGRPFLPFALQDMQVFSACRETM WAVLSSADGAYHIELCDENGAVCVRLTGLTARFLEEETEEKPLLFQPKWQESPLDEGGGQEESFSYVTLYGGMNAEDISG AVCAADGEGPIEDRYDACAAELSAIVTRLIKEKQKEKTLIQLLVPDRGEDNVLAGLAAFLKTAHLEHPKLYGQVIQADPA ESASALLTKLKENRAHPEQAEIRYEDGKRLVRNWRHLPAPQSGAVPWKDEGVYLLTGGAGGIGLIFAEEIASRVKNAVLV LTGRAEALDEDRSARLRRLEASGARVLYQPVDVTDRAAVIALVRGIQEEHGTLDGIIHGAGVIADNYILNQTENERKTVM APKVKGLINLDEAAKDVRLDFFILFSSLAGGMGNPGQAGYAAANAFMDVYAARRNRLVRDNERSGQTLSVNWPLWEEGGM RVDKETERMMYEQTGMKAMRSASGIQALYAAFASGEHQVMVAEGDEKRIRKNLMPETPEPSRSIHVSRKTPVHMPNKVQA ELKHMISGILKVKEDEIDAESEMRDYGFDSVSFTQFANELNKMYGLELTPAVFFEYPTVFRFAQYLLTEHPDTFGSQAET ETEKPVVRKKMKTEPFLIPSRLPKTKTAAAPEPVAIIGISCAFPMAENPEMFWENLAGEKDCISEIPPERWDWRQYYGDP QKDKNASNVKWGGFIDETAQFDPLFFGISPHEAEMMDPQQRLLMMHVWKAIEDAGCSAKSLSGTNTGIFAGTTNSGYAQE ASKFHIEIEGSSAAGTVPSIGPNRMSYFLNIHGPSEPIETACSSSLVAVHRAVRAIQAGDCGIAIAGGVNAIVSPDMHIS FNKAGMLSEDGRCKTFSDQADGYVRAEGAGMIVLKTLSDAERDGDRIYAVIRGTAENHGGRAASLTSPNPKAQTEVMIKA YQQANIDPRTVSYIEAHGTGTALGDPIEINGLKAAFAALYQKAGVTAPDQPHCGIGSVKTNIGHTELAAGMAGLLKIILQ MQHKTLVKSLHCETVNSYISLDGSPFYFVRDTQPWKAATDDSGNELPRRAGVSSFGFGGVNAHVVLEEYVSPVEEKQWTS GELQPSLFILSAKTAEQLKKRAEQLRRYLEKTHSADGALAGIAYTLQLGRDEMEERLAVIAETKEQLTNALNDFLSGKET GQNFFTGRNKAMKQLFTEMTDNAEMSGTVDQWIEAGKYAMLAKLWVQGLHVDWNKLYPDERPKKVSLPVYPFAKTHCWIP HSAQHIRHRETYEIDTSPLETYERLLDELEKNEISIEAAVKRTIGFYRD. DifG (DH) ACP KS4 KR ACP KS5 RNGGNHMKEFLHRVFSDVKNKKMTKQDAIGILRDYDMRMGLRQAASLHPLAQQHISDETGQGFSAAFSGREFFLADVSLQ RKKLMPGELLLEMARAAAVLTVKETEAVRLTHIVWSKPILTEAEPFHIEIRLIPAEGEAKRFEIYNPFSADFSHHDVYSQ GMIQPVDAAPGMLDISRLKENSGFLMDQQQIEAITQNDTVQYSEHMKGIERIYASAGRMLADISIPLTNQKESARFGLPP CVMKSVTEACALLGGKEYKTLAPVSLDELLFYEPCPDKVWAEIQEKAGSFYIDLCDEEGKIWASLSGLKLQPVIKTGAPG KTNAEHRSERLYEQTLLQLKTLFGLTTKIAVSNIDTEEPLETYGIDSVTVTKLNRELSLLFGDLSKTVFYEYKTLGSLAA HFVTDYPKECRKWTNDDDHRSGISEQVLANEDFPVLPSFIKRKKRPAFSNENQTKEGIAIIGVSGRYPQAETLEEYWDNL AAGKDCVTEIPEERWEKDKYYNPDPEAAVKEGKSYSKRGGFLKDAAFFDPLFFQISPRDALNMDPQERLFIEMCWQVLED AGYTKEQLENLYNGRVGVFAGITKNGYGMYWKNGGTLQPKTSFSSAANRVSYFLNLKGPSMPVDTMCSSSLTAIHEACEN ILRGECDMAIAGGVNVYTHPSAYAELSAYRMLSKDGTCKSFGEGGDGFVPGEGVGAVLLKPLSKAMADKDHIYGVIRGTH INHGGRTNGYTVPSPSAQADVISGALEKSGIHPRMISCIEAHGTGTELGDPIEIDGLTRAFQTKTSDKGFCAISSVKSNI GHLEAAAGIAGVTKLLLQLQKRKLAPSLHCRKLNPNIVFDRTPFVVQRELADWKRPVIEENGAQKEIPRIAGISSFGAGG ANAHILIEEYIEPDREIYEPFTDEDPAVILLSAKQEASLKQRAQQLLQAIRKNDVTDRSLRDAAYTLQTGREAMEERAAF IVTSTEQLAEKLQRFIDGGTDGCFRGKSKQYKDILAVFKDEDMQEAVRKWMKRKKFAKLLELWVKGLKIDWSELYNGSLP HRISLPGYPFIKDRYWPDDAAPDNVRDAETHSETFREIRFLQKSWAESSSVPAKEVRGVIGIAADHQTGNLAVELSRYFP ESEIIDAASPEISGDAARFGGLIDVTGCGTEINHDDGWIHRLQSLIDNRNRGRKLQLLCVTKGLEPFANETINLSGAKKA GLYRMLQSEYKDIRSRHMDAERTAEDPELANQIADEFFRDSEDIEVCYRNGVRYHTRLKETNSLAEKEFSFPKDHVLWIT GGTRGLGYLFARHFAERYGVTKLVLTGKETMPPKAEWDDHIKRNSPFSDKVRRIRELEQKGIRTEVLSVSSGPEYEQAVS RVKDQMGPIGGVLHAAGAVDLDHPAFIRKTSEQMMPVLEPKTDGLDLLYQALHKEPLRFFALFSSVSGVMPELGAGQSDY AMANAYMDYFAAAKGFPVLSIQWPSWKETGMGESKSRAYQKSGLKSITDREGLSLFDAIMAGDCGSVIMPAVIHPEKWEP DRLLLSSGLTETKQQEQADTESVEEWLTGICCRELRLEPSRFESDTPFQDYGADSIMLAQVSRAIGKRIKADLDPAVLYE YPTVAALAGWLETAYPEIKAAVSKPVQPVIPDVPKQTAAAVIQPSGAAAAQDIAVVGMSCRFPGAESIEAYWKLLSEGTS AIQRVPKERWKTEKADYAGLLQNVTHFDPEFFLIPEEDIKAMDIQSFLILEEALHLFRDSGYSLQEMKGRSAGVYLGGRG GSMPDENRLKHAKNPIVAAGPNYLAANLSQFFDLKGPSLVLDTACSSALVGMNMAIQALSCGEIDSAVVGGVSLLESGQT HRMFELRNLLSEEPAFHIFDRRTGGIVLGEGVGMVYLKTAAQAVKDGDRIHAVIKGISVNNDGRTAGPATPNIQAQKEVM AKALAKSGRKAEDISYIEANGSGSEVTDLLELRAIEAVYRMQNSAPCELGSMKPNIGHPLCAEGIAGFIKTVLMLSRRMR VPFLSGKEPMTHYDLSASPFYFSHALREWTDSPRIAAVSSFADGGTNAHVIVEAWEQEAYTPVRKPLPRQELKRRPIRSD KAENLHENAHKSRPNTFWKQMKTY. DifH DH ACP KS6 DH KR KLNVDMEEVHMQEQLLINNQHPVLKHHKAYGKELLPGLAYIDLIYQTFRENGFFHAGLELRHLSIFHPLAPEQGETILLS VDCTENGEGQWKVEVKGQKQGDEAAETKVYAAAQMHSVKPAGFQESVRMDAVKQTAAEIPLEDIYAECRDQELVHSGMMK

GCGSVYQTEKEIYIDLSVQKDQLEHAEEAMFHPALIDASSIGSNVYLAPLTRKEGQLFLPLFYESFYCAELLQTTCITKI KKESVTRKKDLVYVTMEFFNEEGRKVGELKNFANKLVRDPEQINQKRQKKEPDGRNAVPAPQPEPAPSEPRRAEASAGLT EQCILYLKELLAARLNKPVKEIDPDIGYYEMGLDSPGLLDMVKEIEQKIGTQLLPTLLFEYTTIAELAGYLCEHYGAGFG HAQSGHSSAEPLPREKKRTTQIRVKKSASAGTQNGDIAIVGMAGRYPGAKNLREFWTNLKNGENSVTEVPRSRWDTRTYE HLRSPSGKPISKWGGFIDDPDCFDAKFFRISPREAEAKDPQERLFLETCWETIEDAGYTPETIVQPKGPNKRMNVGVFAG VMHMDYSLAGAEAAAKGLVFPYPLNYAPIANRVSYFCNFHGPSMAVDTVCSSSLTAVHMAAESLRRGECEAALAGGVNLS LHPTKYITYGLMDMHSSDGLCRTFGEGGTGYVSADGIGAVLLKPLHKAEEDKDHIYAVIKGSAVNHVGTVSGITVPSPVA QGDMIAECLEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLVKAYRTFTEDRQFCAIGSVKSNIGHAESAAGISGLHKTVL QLFHKTLVPSLHSETINPYLRLEDSPFYVQQKTESWKRPAYTENGREHACPRRAGISSFGATGSNVHLILEEYRPKNPGI TEDQERPYIVPLSAKNPERLKEYAARLLMFLKDEAPEGSGPLYDKIDTMQNQLEDALRGVLAEVLHVASGSVDDEQDWKE FGLDVMQLTQFSELMTDQYGLAIDMTDLIQHTSVRTLAECLTNDEKHKNILSGLFGQSGLDKQPDESFSLRSLAYTLQTG RLAMEERLVFLVNDQADLIRKLTEFTEQKRQIDGCFQGRSDSGTEIRGFLNDDQDTEELIRKWTDSGTYKKLAELWSKGF EIDWTRLYREEKPRRMSLPTYPFAKERYWIPEPDHPVTSANTESRLHPLLHRNTSDLLEQKFSTILNGDEFFLADHIVRN KRVLPGAAYLEMARAAAELAAAPLAAGYTAKTGISLRYISWIRQAVHKKEPLRMTTGLSLEDNGNVSFQVYSNENDSDIY CEGSAVIEPLSEAPVLHIEQLKARCRKKVLSKEDCYAAFAKAEIVYGPSHQGIDYIYCGEKEALAKLVLPASVSDEAEQF VLHPSLIDSAFQAAIGVMNEDKAGYPEQPLMPFELHELTVFHPCRPNMWAAVFVTHETPAVRRMDIDICDERGNVCVRIK GFSARMAESAPAVTDNKQYDLPGNLTGAVKLMQVWDAEPIDNQTGFSISEAKAVIIGGTDGQADAVLRLFPKAVRFDIGQ SASVEVISDRLRRLGEIQHMIWFAPRPADSDSHDQKSGVLQIFRAAKALIGLGYGKEQLGMTVITHQAQPITQYDEVRPA HSSVHGFVGSLAKEHPSWHIRLADLEDGGDFPAEDIFSLPRDRTGKAWVRRHQEWYRPQLLPVQSGPSESVPYRYGGVYV IIGGAGGIGEVWTDYIVTTYKARVVWIGRRPLDSRIRQKIDRYRPSGPAPEYIAADASDLPSLQRAYEQIKNTYGTISGV VHSAMVFANESVKDMEESQFHAGLAAKVDISVNIAEVFAKDSLDFILFFSSVISYIKNPNQSHYAAGCAFKDAFAHELSG RLSCRVKVMNWGYWERADNHISEEFDRLSAIGLGLISRAEGMQALETLLTQPISRMGLMKLTKPIPIEGMNPHEFVTI. DifI MT ACP ACP KS7 (DH) KR ACP KS8 DH KR ACP KS9 KR ACP KS10 EDKVLGKGDKQKDRTQLSLRTEISNQMKELNRLLLQVLRVTLRSMGLTGEAPAASCLPLYERWLEESIRLLDSDFKSGET AAVWEEWHKKKNEWLKDPDMKAQVLLADTVIQALPDILTGKIKATDVMFPDSSMELVEGIYKHNILADYYNDVLANEACI YVENVMKNNPEANIRLLEIGAGTGGTSSTLFKKLRPYQNHIQEYCYTDLSKAFLMHAEKEYGADNPYLTYQLFNVEQPAA GQGLHLRTYDIAIAANVLHATKNIRKTLRTAKAVLKKDGLLLVNELGGHTPFTHVTFGLLEGWWLYEDEALRIPGCPGLY PETWKSVLMAEGFHSIQFPAENERLHTQQIITAKSNGVIRQSREAYTAQKRQSNVPQTSSDRQLPIKQAGEGLSEKTAAF LIKAAAKVLKMPAEEINPLAPLDEYGIDSILIVQLTNELRDLVPDISSTLFFEYRTIEELAAFLAETKERELHAQFSEEV RHTEAASSGSLLEKSTEYLKQIVSAILKMPIEDVQVHTPLEEYGIDSILIVQLTNRVREDVPDISSTLFFEYPTIGGLAE YLVSSRQDDMAGIFKTNKEAEKAPHILQKKQSRKKSAGLTKRQAASFSEKAPPASEPPSKHLEVAIVGLAGRYPGAENVN EFWERLKTGEHGITEIPKDRWDWRDYYDETKGKEGRMYTKWGGFLTDIDKFDPLFFKISPKEAERMDPQERLFLETAYAA LEDAGYTPDSLCAGKKVGVFAGVMNGNYPTGAHYHFIPNRVSYVFDFHGPSIAVDTACSSSLTAIHLAAESIRTGASECA IAGGVNLITDPVHYIGLSSMRMLSPSNACKAFGDKADGFVDGEGVGCIVLKPLKKAVEDHDHIYGVIKGSALNAGGKTNG FTVPNPNAQGEVIADAMERAGIDPRAISYLEAHGTGTSLGDPIEIAGLTKAFRRYTDANQFCSIGSVKSNIGHLESAAGI AAVTKILLQMKHGYLVPSLHSKQLNPEIDFETSPFIVQQETAEWRRPVIESEGVTREYPRIAGTSSFGAGGANAHLLIEE YEPAEMTSADTGRPALFVLSAKDKDRLRERALLLSDAAGNGTITDANLLDAAFTLQVGRVPMEERLAMTADSVSELEQKL SAFLKNAGSVSGVFTGRSDSAGTETEGTVSDWMEKRQFDSLLNAWVHGTPVDWASLYKGALPHRISLPSYPFAKESYWMK REEPKTGTTEYVHPFLHENTSTLAEQSYHTSFTGREHVFQDVSGERVLSAAVYLEMALAAFHHAADSSEEKEIWIRTAAW TDPITSGHHGAGVNLSLLSEDEEGIHYEIYSDEEKLHHYGIIGQGNIQPSRVLDIASLQKDCRPLSFDYETPGTSGVTIS KEFRTVEKLYAGESAVWAKLALTDESGRNPGYHIPPEFLDAAFHVLAKTEPSVHIVPEAVEELRVMRPCSSGMWMYINKK NQTGCDIQFCDETGIVCAEIKGVRMRQPSQQDHGQKEQSEMMIFEEMWTQQPLKKSIHEELKTVICFLTGEAARKHAYQS LQSLYPESGVFFISQGEETQKLSNTHYQIKITDGQAYQETFRHIETAAGKADAVLYGWPLEDEKAVKDYSILYHVIRAAA SLRSKPRRILLSAQCGTDTDISYAESWIGLERSLKLILPETDTAAVYFEQKGPFEKLIHNVCEELHSEWFRSVMYSEEIR HVMEMKQTDIAPVEKRVIKSGKTYLITGGCGGLGLLFAGYFSGKGPVTLILTGRSAADGSVLNKIKRLEESGAKVFYVQA DAADQAQMEKGLQEVKEKGCGPIHGVIHAAGLQGTESILEKDLQTFQQVLSPKADGTAVLDQVLSREPLDFFCCFSSSSA ILGDFGSCDYAMGNRFQMAFVRHRDKLVSLGLRSGKSLAINWPLWKEGGMHVGTAESTDMYLKSSGQRYLYTEEGLEAFE TLLVQPSSQYLVLAGFPSRAKRFLQIDQGERPISGSVNRNVPFSGRRSEMKGFTLEECVSWDVKELAAGLLKIDKNRLTD ADNLADFGFDSISLAEFASSLSAHYGIEVTPALFFGHSTLEKVVRYFLTEHKSVMEHVYEEKKPESADQSVFEKAGTKKR KKQRGRNKLNAGTEGSQAADSIAIIGMSGRFPQARTADELWDILFQEKDVVAPVAKKGFTSSKWKLGAVPGADEFDPLFF EISPREAETMDPKQRLLLQEAWRALEDAGYGASHIRQQTIGMFVGAEEGDYHLLTRDKGNVTSHHNGILAARLAYHLNLS GPVMAINTACSSGLVSVHQAVLSLQNKECTTAVAAGVNIMNTPDFFETIDKAGMLSENGKCFAFDKRADGMVPGEAAAAV VLKPLREAEKDGDPIYGVIRASGINYDGKTNGITAPSGVAQTRLLTSVYDRGRINPEDIEYIVTHGTGTKLGDPVEINAL YDAFSAYTNEEAFCALTSIKTNIGHTFAASGIVSLISLLQAFSREMIPASLHCSGENRYINWEKSPFYVNKTGKPWPSLP GKNRMGAVSAFGMSGTNAHVVMESYKRSASPHPDAPAYLLTLSAKTEDALQEKIEDMITWAENGGLKENDLAQLSYTLLK GRHHFNHRAAIVVQDADDAVYVWKQAKLNEHHPYVFSGKVPQHFAGRQHIQEHIIEVLDKCSASYSDHRKYQELLCVLAD FYCQGYEIEGDLLYGGPLPRIGNLPGYPFARQTYWASDRLQRELESRNSAEREKLHPLLHANTSTFTAQRFTSVFSGHEP FFADHIVNGKPVLPGAAALEMARAAVTLAAEDLPGGKTGVRLKQIVWLRPVTALSEGVTLHVKLQPEENGDIAFEAYAEG EEPLVFFQGKAVLEETERAPVLDVEAVQARCGGRRMSKAECYEAFDSLGITYGPSHQALDAVYAGSGEVLAKLTLPPSAR EEKEPFILHPSMLDAALQASIGLVLSDGSASGRPFLPFALQDMQVFSACRETMWAVLSSADGAYHIELCDENGAVCVRLT GLTARFLEEETEEKPLLFQPKWQESPPDEGGGQEKSFRYVTLYGGMNAEDISGAVCAADGEGPIEDRYDACAAELSAIVT RLIKEKQKKKTLIQLLVPDRGEDNVLAGLAAFLKTAHLEHPKLYGQVIQADPDESASSLLAKLKENRAHPEQAEIRYENG KRLVRNWRHLPAPQSCAVPWKDEGVYLLTGGAGGIGLIVAEEIAFRVKNAVLVLTGRAEALDKDRSARLRRLEASGARVL YQPVDVTDRAAVIALVRGIQEEHGTLDGIIHGAGVIADNYILNQTENERKTVMAPKVKGLINLDEAAKDVRLDFFILFSS LAGGMGNPGQAGYAAANAFMDVYAARRNRLVRDNERSGQTLSVNWPLWEEGGMRVDKETERMMYEQTGMKAMRSASGIQA LYAAFASGEHQVMVAEGDEKRIRSHIFDLGEEQSAAGKAPAVADARDLKDQVQEKLKRHVSDLLKVSMKDIEADSELTEY GFDSIIFTEFTNLLNRSYQLELSPTIFFEFPTLRKLSGHLISEWKEAFSGLEGERLKTAPKAGIRKAEAPAAVHVKRETP VSVKGRSEEKTEPIAIIGISGIFPQAKDIDEFWTRLQKGEHCITEIPRDRWDWREYYGDPAADANKTSIKWGGFIDGIAE FDPLFFGISPKEAEMMDPQQRLLMMYVWKAIEDAGYSAKRIAGTKTGIFTGTLGSGYQTLINKAGLPVEGYTMTGIVPSV GPNRMSYFLDIHGPSEPVETACSSSLVAIHRAVKAIETGDCDMAVAGGVNTIVTPEGHIGFQKAGMLSEDGRCKTFSDQA DGYVRGEGAGMIVLKKLSEAERDRDHIYGLIRGTAENHGGRSASLTAPNPQAQTDVLKSAYQKAGIHPSTITYIEAHGTG TALGDPIEINALKKAFQTDGAPGGYCGIGSVKTNIGHLELAAGIAGVIKVLMQLKHRTLAKSLHCENINPHIKLKDSPFY IVTETKEWEALCDENGRVLPRRAGVSSFGFGGVNAHIVIEEYMGKSETEQQETREKASSLFVLSAKNEERLKERARLLRD FIQNGSSRDIDLADAAYTLQTGRDAMEARLGIIAGSAEELTEKLNAFLLGKNSEDIISGRKKRENNTISMFSDDEDAADL VSAWLEKKKYRKVLRLWANGFDTDWEQLYTDSKPRRISLPSYPFRADRYWVPKREQLPLSNQKTVLLQKTWEPCEALSSS EPFNNKIALIVSEDTKDLAAEVKKQLNDADIVQENQLISFLQGPNAAIYSGFIDFTGCGSRQKRQDISWVASLQQLIEYG RGQENMKMLYLTKGLEAFKNKAAVMHGIEKAGLYRMLRHEYSQILTCHADIDPEEPLEQTAAFIKQEIESDLTESAVCYR

DGMRFSYVLQQTDQIEPEAVQTDRTAFPKDAVLMITGGTRGLGALCAKHFVSAYGVKKLLLTGRKELPPKTEWDLEQTDP VVSEKIQLIRQLESQGVKVCVSAVDLTDKQAVGRLIKEVTTTLGPVGGILHCAGIADRENPAFLRKSKDSIARVLAPKAD GLHSLYESVKDDAPAFFVLFSSVSAAVPILAAGQSDYAMANSYMDYFAENNESGIISIQWPAWDETGMSRDTKSGIYEQT GLLRHSDAQGLKMLDYILRERPGAVVLPAQVKHDWDAKALENAKPAAHKGMRTASKPPETKKREHNRIDIQSWLRSLLAK ELSIDETHMDIDVPFQEYGMDSIFLAQVLTKIDQKLPSVSIDPTVLLEHPTIEQLADYLAAHCPEAFSADAAVPAEKVPL QKTPKRSKKKADKPGKRGKVAIIGMACHFPKAGDIKEFWKNLRSGTDAVTEVPPDRWNAGEHYQPGEYQEGKSISKWGGF IHDIDQFDPEYFNISETLAPMIDPLQRQWLEVSAEALADAGYQKEDLWGRRIGVFAGARAGAFHHKFQYLKKDAIIGAGQ NFITAHMAHIYNFTGPNLVVDTACSSSLTAIHLAVQAIQNGEAEAAFAGGVDILLDEKPFLTMSAARILSPNGRSKSFDA DADGTGIGEGCGVLMLKPLEKAIEDEDKIYGVIDGSAINNDGSTMGVTTPNPRAQQDLIEQAVQSAEIEPDTMTYVETHG TGTLIGDPIELKGLTNVLSAYSDEKQFCGVGSVKSNIGHLLSAAGAAGIIKVLLAIANEELPPTLHCHKPNPRFQFNDSP LYPVLELKRWDGKKEILRAGVSAFGLGGNNAHIIVSNEGIPKERKAAMEPKGGQTVYRKQRYWPEKAQLPEAEENEAGTE AMFEISEV. DifJ (DH) ACP KR KS11 KR ACP (KS12) ARCDRLAVATDQVKTFLQKISHTNYIVRDHRVHQIRVLPGVTLIDMLYRLAAGYLGERPIELRQIIFKQPVVTSEEFDKH LYVTFTPARDSWKVEITSEKAKNGTPLGGNRDENMECQLYLQEDAPRAKELNIEAFMKNASRKWDMHDIYGIARRSHIEH GEFMKNEGAVYQLQDKEELMELTLSDLAEGFREKFKAHPAFLDASTLAGSSFALSAQKQNDTPYIPFMIDRFCMYQPFPK TIYTYSAKNSRTESGVSDSEPDVYSADFTIYDRAGNVLAECEKLTVKRVRQANMITHLIDKEKPPQQNRSGRGESENSVA AEDVSEQQTPEQNMVTYIKSEIARLINRPAQDIDVRKGFYDMGLDSAHLLKLVKILEQTFQQQFYPTLLFEYSSVRRLAD YLINEAGCVLKDSAEDRHTSDTDIADEVLFFEPAWKDHPLETAVQNGQKQTRHLIIAADAGPRLTGELGTYCPEAEVIEL KREHEAADEQFEADAERIFRMLKRELTDHPKEHTLIQLVCAVENGAALSSALGAMLKTAHLENPVLRTQVITFCDKNERL PSETAAMIRTEADCSHAGCTDIRYKDNIRQIRLFERIEKLDGQTQSPWKQNGVYIITGGLGGLGFLLARHLAEKEKVKLA LIGRSPEQSEKISRLKALGAEVLYVQADIGSKAETERAFAQITETFGRLTGIFHCAGVLKDQFIIQKDSSDLKRVFLPKI SGLIHADEASRHEPLEFFAVFSSFSALAGNAGQTDYAAANAFMDEYMKYRDCRAKKGERTGASMTINWPLWEDGGMQVDS LMKEIMNDATGTSPLPAGEGMASLEYMLRLGKLQSVILYGKEPAVTESMARLVPMADKNRSSLSHAAVKRRSRKQERHTE EHDIAVIGLAGRYPQAGSIDEFYQNLRSGKDCITTMPKDRWKGYPFSYEADQFYRYGGFLDRIDSFDPLFFNLTPRQAEM MDPQARLFLETAWEACEDAGFYQDRTARGPSSQKRKRVGVFAGVFWSHYELFGAEITQRGTPLSMGVTPASVPNIVSHCL NFTGPSMAVDTMCSSSLTSIHLACESIKRGECEFAIAGGVNAVTHPHKYAFLANAGFLSSEGVCKSFADGGDGYVPGEGV GAVLLTTVQEAERMGCPIYGVIKGSALNHVGKTSGLTVPDPASQAEVITDSFQSAGIDPETLSYIEAHGTGTSLGDPIEI EGLSRAFRKWTNKKRFCAIGSAKSNIGHLEGAAGIAGLTKVLLQLKHGEIFPSLHADTLNPHIPFPDTPFYVADRLEEWE RPSHPDQPRRAGLSSFGASGSNAHFVIEEYLPPQAEKKSVNIREDEPVLFLLSAKNEDRLLEYVKRYDRFLREKEVNLKD LAYTLQAGREAMPERLAFIVTSVCGLQAKLKDVLERKTEIEGCFRGRAQDDISSSGMAELLKNKQYSRLLTEWAKGAAVD WSLLYEGEKPKRVSLPVYPFAKERYWVPVPADIRKQTDEPAENQKIILQKDWKQQDPAESEALSGTVMILATDKTSRLAD ALFKGNGHIETICFIHQAKDGADYYAAASGRNLYGRVRESLQNKQILGVVDITAYDAEYERQEEIEHGKLAFLQQALESL RHSGAVFSQVTHRLQPFKESKPLMQGAKTAGLYRMLGAEYANIHSFTIDSDCEIEHTEELSRQIETEFLQPRAKSVSECC YRLNRRYVPFLKQGMNVSAAPELSYSSDDVLLITGGSRGIGAIAAEHAVSRGCRKLVIMGREPLPDSSEWADMKKDGILP EKAERMQRLAERGAEIRYYSVSLTDQKGIRKMTDSIRGTMGPITGVFHCAGAMGEHPAFYNKTETEIESVCKPKVTGLRG LYEAVQNEPLSFFILFSSVSGLIPSLAAGQSDYAMANSFMDSFANHQAGKGNVFVKAVQWPVWKETGMAEGLPETPAYQK SGLSRLSAEDGLKFLDYIILNGQSCGIPCVPEDSEPDFGDLLKVKKSEAPMKKSTAGDQKVKDMIRQWVRTVFSEELKMT DEQIKDDMPFDEYGIDSILFAELVQSLQKRISIKLTPSLMLQYQTITEMVDYFAVHHEADFVTKENGFVQDRDVEPDLIA DAEERTFMEPKADTEDDIAVVGMSCRFPGAGGTDAFWELLMKGNTAIRPVPATRWHATANAKDYAGWIDDIDMFDAGFFG ISEKDAAIMDPQARIILEEAVHSVYDAGYGQKDLSGRKVGVYIGGRAQPSAGMEHILQAPNPILGAGQNYLAANISRFLN VTGPSLVVDTACSSGLIGLSFAKDALLAGRIDAALVGSVSLLLSPSAHRLFGARHILNENGVFHIFDRESAGEVLGEGAG AVFIKRLSDAVRDGDRIYGVIKAVSVNNDGRTLGPGSPNIRAQRDAIQTALDMAEKSPEDIGYIEVNGGGSPIVDSVEIK ALSDVYQLNRKTLLPCRIGSVKPNVGHLLLSSGLAGFIRCVLSVYHKRIPPFLSAREPFEHYDFEASRIHFNREPVDWHS EKKPRVAAQSSFPDGGTNAHILVEEYRGERQREHHRASQPPEFRKKHYPLLGGWNSTENEAEKTSNEKTDIADILKKYEK KAETSTAPADSFWQVTT. DifK DH DH KS13 DH KR QRDVFKRGLTMKKTVNLRLTAEHPIMKNHLVHGESVMPGLAYIDMLYQLAKQSLDLSFRSICLKRVTIYHPLSVKRSERL DVSVIFSKEKEFWTASICGADSGTVFLSAEVHEGVFLSDKRLDAEEKKQVALPSVSLHTVYEDARSRGLSHDGLMKPEGE IYANEEECFLDIRQSDSCQENLPGALFHPALMDGAAMASGVLQTAAGAGLFLPIYYDSFIAAETVTERCYAVISKKSGTP SEMVKMDIDFYNLSGAHIASLLGLTAKKVRTDRQLIPGVQQMEETLYRIFSTYVGRPVTRNDAHTVFFELGLESSQLLAI IKDIEGAFDLRLNPTLLFECSSISELLEDIKTKGTGESSGLVADAAPVSETQSVSQTFTFYEHEAFLQDHLVFGKPALMG VVYPCLVLEASGASHSGTYPAELKDIRFTGGPVTLEPGEAAQIDISFAAEKSAERFTASCTVSGKESRKTCAEGEISRGI EAPVKKSYDVEQMKAHAEKVAPDVISRLYDSVAGFMIGPMLKTVTAGYKMSESSFLLQLDLSGKKEKGDLRHFAFDPLIL NSCYMSLGEEELQLKKRIHVPLMIERLTLYGPVMSDTVYVVNTIKHKKDGFLSFDAAVLSHTGEQLAELKNASVKEVLQP NRLENASFAPSGNQNRPKTKGKPLDIAIVGISGKYPQADDINAFWENLKQGKDCITEIPKDRWKWEHYFSEDRTAPGAIY SKWGGFIDGIADFDPEFFKISPREAEHLDPQERLFLMHAWMAMEDAGYTRTSPELGRQVGVYAGVMYQEYPLFAAEAGVK GRHIGLPGGISSIANRVSYFCDFQGPSISVDTMCSGSLTSLYMACRDLRDHRIRAALAGGVNLTVHPNKYFMLSQGQFIS SKGHCGSFGAGGDGYIPAEGVGVLLLKRLEDAVQDGDRIYGVIKGAAINHGGRASGYTVPNPKAQSEVISQALQEAGVSP GQISYVEAHGTGTKLGDPIEIRALTDAFGDVPETCLIGSVKSNIGHGESAAGIAAVTKVLLQMKHKQIAPSLHADVLNPN IQFDEGPFSVCRELTDWKRIAADGAEQPLRAGISSFGAGGSNAHIIIEEYEAPVKQAISSQEPAVILLSAKNGERLTEYT ERLLAFLQKKHTDKPDLFDVAYTLQAGREAMDERLAFIADSLKELEDKLRSYLENENAPHLYRGRAKRNHETVAVFESDE DLQEAMVKWLKKRKYGHLLNMWVQGVDVDWNLLYSGQKPRRISLPAYPFAKVRCWIQDEAEAVSKRNDGKTVIHPLLHEN TSDLWELKFTSVFTGREFFFTDHTVNGEKVLPGAAVIEMARAAVERAAYAVPDGRKGMYLKDLIWMRPVVHKGTDVEVHI SLILKGNEDIEFTIYSLSEEPGGERIIYSKGTAVSGEIAAVPSVHLEGWLSGCSQSVMTSDEVYQAFRHAGMIYGPSHQG IDQLMIGERGAAARLSLPETADSTADQFVIHPSLLDAAFQASLGAGSDTAGDTPMLPFSLRQAEIFLPTQKTMWALVRKQ SDRSDNGALTLDIDLCDENGAVCMRLTGFSCRAVRQTNQTESKRQEVQTAMLAPVWDKTFFSLEENRAVDQEQLLIIGKP GNTIKDAAKMWPRAHLAETPDHSSEQTLRELTAGYQDIRHFLWIAPDRFAPASVSQEMLDEQENGVIQCFRFIKALLSLG YGNRNISFTAVTRQTQSVYPGDLPQPEHAGVHGLIGSLAKEYPNWDIRLIDAEEGSDSSEMKDIWRLPPDPDGNAAAYRN GAWHKQKTVRVLTSSAPRMSYREAGVYAVIGGAGGIGEAWSKYMITRYKARMIWIGRRPKDQEIQSKIDRLALSGPAPHY IQADAQDAAALKAAVRSVREQYGNITGVIHSAITLADKSMANMDEASFRNAYSAKVNTSVRMIEAFKGEPLDFVLFFSSV NSFTKNAGQSNYAAGCTFQDAFARHIASLLDCEVKVMNWGYWGSLGVVSDPSYRKRMEASGIGSIEPDEAMEALEVLLSE PFSQAAFIKAAPHGLAALTDQDAISVVSGPKPSFMESVKRQNPDRNERLETLKREMELRI

DifL MT ACP ER KS14 ACP ACP TE DFKTRNGVAHMNRLLCKLLFYQLQSIGFFSEPVTTPAASMRSAGVIGTYGRWLEESLNLLKENGYIAYDGYTITLLTDQR PDGRTVWNEWNAHKRLLPNGELAQAELAEATIKAMPSILKGERPATDIVFPDSSMRLVEGVYKHNPVADYFNEVLADSAA AYLKAYLTEHPDARIRLIEVGAGTGGTSAMLFAKLKPFAKQIAEYCYTDVSKAFLMHAEQEYGPDVPYLTTALFNAEEPC ESQNIKTGVYDIVIAANVLHATKNIGLTLRRLKALLKYNGMILINEISDRSVFTHLTFGLLDGWWSYEDAELRIPGSPGL YPKSWERVLHSEGYRAVCFAAETAHNLGQQIIAAESDGLVRMQGIRDGRKPYAAPAEVFRKPAQPVSRSRAPEEHQAVKA DGESVASHVRSVIKTSIADVLKMKEEDIQEELNFSEYGIDSILAVNVINEINKRLNLTLQTTILFDYYHVKLLTGYISEE YETIIASSLKAERAKIRPALQEERPAEKPLQTERKENGYQKPKQERMPPSFAKSDDSGMFRVVIDRPGGIEDLTIARSEV PETKDDEVQIAVRAFSLNFGDLLCVRGLYPTMPPYPFTPGFEASGVVIKTGRHVTSVIPGDEVIVGMGEEFGSQANLITC KEHQVYHKPARLTFEEACALPTVAVTMIDAFRKAGLKKGEKILIQTATGGTGLIAVQMARHIGAEIYATAGSQKKIEYLH SLGVRNTICYLEEDFETEIMRMTGGRGVDVVINTLAGDAMQKGMNCLAPGGRYIEIAMTALKSAKSVDLSVLHNNQSFHS VDLRKLSLQNPDQVKDYQLELQRLAEEGVIQPVISKIFSFEDIKEAYHCLDDRGNIGKIVISVSEPYQMTYRPEQKDPAD TVKSAAVLPEKEPIAIIGMSGRFAESENLHEFWEHLAAGRDLIKKADRWDVSDSQCQYGSFIEDIECFDPVFFHISGREA TYMDPQQRLFLEESWKALEDAGYAGDSVRGRECGVYAGSCGGDYQAIFKQQGPAQAFWGNHNSVTPARIAYHLNLQGPAI TVDTACSSSLTAIHLACQGLWTKETEMAVAGGVFIQSTPAFYQSSNKANMLSPTGRCHTFDQSADGFVPGEGVGAVVLKR LSDAVSDGDHVYGVIKGSAMNQDGATNGITAPSALSQERLERHVYDTFHIDPETIQMVEAHGTGTALGDPIEFGALTRAF RRYTDKKGYCAIGSVKTNLGHAAAAAGMAGLFKILLSLKHRQIPASLHFHQANQHIQFADSPFFVNEKLIPWERNPDAPR RAAISSFGFSGTNAHLVIEEAPQTVRRSPAKPVCLIPLSARTERQLEIQAERLLDSLSKNKDSDLGNISYTLLLGRKHLH HRFACIVSSADELKRVLSEWLVKRELPGVFVSNLKDQKPAEEAGMKTFGMECIEQCRSAASPAQYRENLAHIADLFCRGY DLPFTRLFDGGQYYKTPLPAYPFLKERYWAADVNSSLPGQAMKKSETQTVLPSSPQPEHEGLISLSPLTEIEMTAFEPET LQKPIVLQPLDCTVSVQQPEKAVSEDNRTLLEELRTSLADILFLSPEDIDADEPFIDMGLDSIIGVEWIQSVNKTYHTEV TANKVYEHPTLEELAEYIAGQIKKPEYAEAEETAVRPQIPEAETPLAGISDGTLRKELKDSLADILFLKPEDIDEHEAFI EMGLDSIIGVEWVQSINKTYQASITANLVYEYPTIATLAGYLTGSVQKDTEEVHGEHTKQNDISEETDDQEPPELICLNP GGKGRPIFWFHSALGAVELYQPVAERTGRPFYGIQARGWMTDREPIRGIKNMAEYYVKLIRTVQPRGPYDVGGYSLGGML AYEVTRQLQLAGETVESIVMLDSFDSAGAREINIPDELFDKNMMLQTVNMALFAPIYQHPERISETLIHRDELNADLHED IFLEQLIAKAKQRGLTKTDALVKNLIRQNINVQDAYEITDYELLPLPDPNGVTCYYFRNKNGIFLGELDPYFTIRADILS ADFVNYWSQWEEHMTNIAIMDVAVSNHMTLLAEDSTAETISEFCGVLYSADGMTEYSFLQLQEKILNVHGEMLKQPAKTR P Disorazol DszA KS1 (AT) DH KR ACP KS2 KR MT ACP ACP KS3 KR ACP KS4 DH MEQDAIAIIGVACRFPGSPDYGRYWQLLERGEHAILEIPPGRWDPRAHYSPDFNKPGKSISKWCGLIDDI ASFDHRFFNVSEREAKSMDPQQRLLLEEAWRCIEDSGVPLEQLRARKTSIYVGFMATDYHQESAAPGRPV DSYAALGSYGSILANRVSYTLGLRGASIAIDAACASSLVALHEARRALQRGESEFALAAGVSLNFHPWKY VSFSKSRMLSPDGLCKTFDADANGYVPGDGVGVLLLHPLAKAIAAGCHVYGVVAGSAVNHTGTARSITAP RVAAQRDVILEAYEDAGWNPETVTYVEAHGTGTSLGDPIEVEALTQAFRRYTTARQRCAIGSVKSNIGHL EAAAGVAGVIKVLMMLKHRVIPRTLHVQTLNPLIRFEETPFVVATRAMEWRAEGGEPLRAGVSSFGFGGA NAHVLISEHGGARREPRPRGELRGPRGAAPRGETAGAPAEDGPLARAEELPSQQEDAAADEREGTVFLLS ARSASSLSRAVRRWEAFVDDPLVKAGLATSLRDICATLAAGRQSFEHRHGFYIDDERDLRRLLKEPPARL EKTRPPRWVTRFGALALGQGRPAVRLLGARRLLDPHLDRIRRCLEELGIEHQDLRTYRQDGDPGRQELPY AFLFAHAYVSALADLGFTPYATSGEGHGIWLALAQSGVLPLNEIVSVLSGAGELQRLSPRRPRLPLFDPI HSTYLMPYLLDAGYVRALVEGLAVPAATLRDLLARARLLLRAQFTFKKFLSEWSPALQALGTTPERLLEE ELPASDARASLIALIAQSCVRKLNRRWQLTDAPSSGDPRFDELVDLVVDGLLPREALVQLALGDRADLHE IAGTLHRRQDLLDLSQPYGILRRRSERLDPSEIDDFSGWIRQIAGLEAPGLPPEEGVAFLELGRVARRAQ RAPGPDLSVPALDSPLQLVALRLWLEGTDIRWGELFPEGSFAKIPLPGYAFDQAQFWLPAAREGTSPPED ARDDADARHAAVAPHGAADRAERPSIPVDRLIADHVIQGRAIVPGALMVEMALEASQRAHGRPAAVLRDI VFQRAVPLDAHANLTIDVDPDGGRFVGRDGAQGACRGAYGSAPPSPLEPLDAPARDGDRRRDDSLYRDLS RVGYRYGESLQVIAATGRVGSRHVFELRSSVARTTPVAGFDPALFDGLLQAALVVGQRLGLFGGGGAIYV PQAIALVERLAPVDGGCLVCIDERDLSIKEYGLTVDLRAYDPSGAGLLRVEGIFFRKVLPGFVESSPARV TGGAAEAPRRAGAAGDPESAAPRAACYQPVWERRPLPDRGGAPPRGRAVAIIRSEADSAAWLSPLRARYS QVTVARLGSPPGEAGEDRLVLGDDREEGFSELVRRAERAAAGEAVDIYLLDALTPDARVPSRAPAALEPA LGPREEAAARSAFLLAKALVKSAAPWRLVIGTRRCQAVVPGDRGEGFRHGVLAGMARTLTQENPRVQVHL VDFDAAPPLACAGHLVEECGVLGPGDWVAYRDGARYVRAFAPVEEPGATATPPFQDGRVYLLVGGAGGLG LGLAGHIASRAHARLVLLGRSPLGHEAERRLARLRGDGGETLYISADVSDPQQCEQALAAVRQRFGAIHG VVQMAGVVEDKLIAGKTWESVRREMAPKVQGTWLLHELTRRDPLDFFVTFSSVVSLLGNHGQVGYAAANG FLDGFIHHRARTGAAGRSLGVNWTLWEDGGMGAAPGIVRRFSARGLPPIRQHDAFGALERLMTGGRSPQA LVLAEPAEHLFARASTRPAPHAVAPDPERGDREQARDKEQVRGDASMTRTTANPHGTAPAGAGQDGRRIA RIEEDLRRLVSARIEAPSQAVDAEESFFSLGVDSVALQEITETLERTYGSLPPTLLFENPNIRQLARYLA ERVPARSAAPAEVEPAQAPASGPAEAPPAARAAVPLPAPEPPGEAASRGARVAAVAAGQEHDTPGAPSTR AARRESPSDGPAIAIIGMSARFPKSPDLDAFWQNLLSGRDCVDEIPAERWDHRRYFAEAAQPHKTYGRWG GFIEDVDRFDPMFFNISPREAEQMDPQQRLFLECAWATMEHAGYGDPRAYGDRAVGLFVGVMWNEYSRIG SQLTLQTARYAGPGSLYWAIANRVSYWMNLTGPSLAIDTACSSSLVAVHQACMSIRNGECDMAMAGGINL SIHPDKYLYLAQSKFLSLDGRCRSFGQGGTGYVPGEGVGAVLLKPLEQALRDGDHVYGIVRGSAINHGGR ATGFTVPDPEAQARLVFDALRRARVSPDQLSYIECHGTGTALGDPVEIAGLSKAFRMAGATRTSIPIGSV KSNLGHLEAAAGIAALIKVLLCMQHQAIPKSLHSDVKNPNIRFEEVPFEVVNETRSWQGDGGAPRFAGVS SFGAGGSNAHVILESYEPHVRLSAGDDAAEGGALIVLSAKDRERLDALAGRLRDFLRERAGRAPSLSDIA YTLQLGRQHMDHRLAIVAASREDLLAKLDAVLAGRGEVPGAFRGDVHGDKAASLAMDGDDHDREYLERLA RDRRLDRLARLWLLGLRVPWEELHRDRGRKRVALPTYPFARERYWLPDVESSITAAAPVEAPASEQAPAP RGEKGLPEDFFFHEQWSVAPLDPATGSDGAAVRSALVIYTPEGEALADALIARHPGARVARILLGAGQGA

KGRPGPEARAARLPPAQEVQADDPAALERALRELAAAGVAGLDAIYFLGGLAAQEPAAGDLEAVERAQQR GLLSLFRLAKALGALGLSSSPCQLKIITNDACSVRTGDPERPLAAGLYGLARSIAKEYPRLNVSCIDIQT RALSHPADEGLISAVIAEPGHLRGREVALRDGKRFQRTMAALPLQPPARDPYRPGGVYLVLGGAGGLGHL FSQHLAGTYRARLVWIGRRPLEADIRSRIADVEARGGEVLYLQADAGDPSSLRAAVSRAKARFGAIHGVI HSAVILGSHPIATTDEATFAAGVRAKIAGSVALHQAVADEPLDFLLYFGSIASYLNNGGASPYAAGCTFQ DRYAAFQRSRVPYPVKLINWGYWGDVGAVAGNTETHDQQFNAIGVGAIAPEDGMEAARRVLAQRLPQVIA AQLTRPPQSLFGYDLSHEATVHPERFEPLLERSVPRIQPGLSAVRELLTHQPAFDALERFSEDLLLCIFQ DMGAFQRAGSAESAATLRERLGVAGRFGRLYDSLLAILEGAGYLRIEGDRLFTSERVTPKKHEVERRMQQ LADLPAIAPYVRLLWACYRRYPELLRGQVAATDVLFPQGSMDLMGPLYKGNATADHFNELVIKSLLVFLD ARVPHLREGEKITILEVGAGTGGTTASVLEALSSHARHLEYFYTDISHAFTRYGKRQYGPRYPFVTFQPL DLEGDVVAQGFSAERFDVVLGANVVHATKNLRSTLQSIKRLLKANGWLVLNEMTRVVHFLTLSAGLLDGW WLFEDAAERMKWSPLLSSPMWKGLLEEEGFRRVAPLQHSDGTSSWSIQNVILAESDGVSRSRRTESAAPR PAPSATSAAAASEALPPAPSTPAAEPVAAFRPMSLQAVEDKIIDSLASTLQIDRSKLSSDVPFTTFGVDS IFAVEVAGVIGRELSIDLRTTALFNYPTARALAEHIAATFAPSEAAPARAPEPAAQPREQLPSSPPQPAP GAPPRPAQATSQVQAPAPERPPAPQPAGAQQRVRQLALGALAEVMAIDVRELDPSATLAECGIDAQQAVV VVSRMNQALGTSATAMDLLRCGTLADFVDHLLASSPAPRPDAETRPGTAAALPAPAPPAAIEPRSARSTD IAVVGMSCRLPGAETVADFWRNLCEGHNAIREIPPDRWSLDGFYDPDPSVAARSYSKWGGFLDNIGDFDP LFFGISPLEAELTDPQQRLFLQEAWKAFEDAGYSAEALSGQRCCVFVGCKDGDYVYKLGPSADASYRLIG NTLSILAARISYFLNLKGPSVPVDTACSSSLMAIHLACQSLISGSSDLAVAGGVALMTTPVSHIMLSKTG MLSPTGSCRTFDDSADGLVPAEGVAAVILKPLDAALRDRNHIYGVIRGSEANQDGKSNGITAPSTPSQAA LEVEVYRKFGVHPETIGYVETHGTGTKLGDPIEIHALTDAFAAFTDKKGFCPVGSVKTGIGHTLAASGAA SLIKVLCCLQHRTLVPSLHYDRPNRHIHFENSPFYVNTARRHWAHAGDLPRRAAISSFGMSGTNVHLIVE EAPPEADATAPTVAPYTLIPISAKAPAPLHRRVADLAAWLDAGGRDRELGDIGYTLGVGRSHFPLRLAFV ARDTRDLRRQLAAWLARHPTADDVPAPAARPEPALGQTAGRLASELRDAPPLTADAYREKLEALAHAYVA KHDPEWQSLFAGQDRRLISLPTYPFNNRRFWVDEPSRYGLDHAAPAASAAPAPRPEPAPAARLAAPAEQP GHGDRRADSLLYFRSAWETAEHEAAAGQLRAPILLFDDGGAVRERLLDSDRPVIAVTPGPGFRELGGGRY ELNPGDAADYGRLVAACKQRGALPREVVYLWPLARAQAQAEPTAPFFQATSLCRALADHRPAHGEAVRIL YVYWQDGDRLDASHAAMSGLARSLQLDLPHLHWKTLGLEPRTADGALCDLVLAELLAPPQGAVRYQRGHR QIQRLQPWRPEGEASAPFRSKGVYLITGGAGGLGGLFAEHLARRHQARLVLCGRSPLTPAGDDLLRRLAQ LGAEAVYVRADVADREDVFALLGRVEARFGALHGVLHSAGVTADASLRNKSRDQMVAVLAPKVLGTLHLD DATRHRELDFFALFSSVTAVMGNMGQTDYGYANSFMDHFAAWREAERQSGRRSGRTVSINWPLWRDGGMS VSQEMQTLLTSTLGMSALSSDAGIQAFERAVASAHPQVVVLAGDEAKIQESLGIAAPTPPAGALPGSHGA PPAARAKAPPARSALAKQVEELLLQAVSGVLKVAREELNYDAPLRDYGLESINVIALTNHLNRTYALDLK PVRFFEHETLAALGGWLCEERGEHLARRLGPSRAPEAGLPAAPAAPPEPAQAAPAQPAKEPPARSARAAE RVPPEAPSARAERGMAAHEPIAIIGIGGALPKSSDLSAFWQHLVDGRSLVSELPADRWDWRAYDNGDANR KGLRWGSFYEDMDKFDPMFFGLSPREAELMDPQHRVFLETVWKAIEDAGYRPSDLARSNTGVFVGASSLD YLELMNGHRTEAYALTGTPHSILANRISFLLNLHGPSEPINTACSSALIAVHRAAETLRSGACDLAIAGG VNAILSPATALAIAKAGMLSPDGKCKTFDRSANGYVRGEGAGALLLKPLRRALADGDHVYAILRGSAENH GGRANSLTAPNPRAQADLIIAAFRAAGVDPATVGYIETHGTGTALGDPIEINGLKTAFEQIYKDHGRPPP QAPHCGLGSVKTNVGHLEAAAGIPSLFKVLLAMKHRKLPGTLHLHDLNPYIELEGSPFYIVTRTEDWKPA LDADGRPLPLRAGISSFGVGGSNAHLVLEEHHDERAEEPSAAEVRRGPHLIVLSAKSEERLHAYVDALIA YLRDTAPERRPSLGHIAYTLLTGRDVMDARLACVATDTDDLVTRLSRYRAGESAVDGLFTGRSDGSSSAA AVLIEGEEGQQFVEALLRNRKWAQIARLWVAGRTGIDWSSLFDGERVRRVPLPTYPFARERYWVPDEIGK EHAGNGAPPAVNGKAHNGAAEGGARPPASAGSTLRPTLDAARSSPERPVFQKELEADAFYLRDHVIAGNI ILPGVGHLELARAAGELAGGRPVRVIRDVLWAKPILLDGPRLDVQVAVSHDRQGAEYQIRHEGEGREVLY SRGRLAYEPAPRRDGEPERRDVKAIRSRCHDRKDHDTFYRRYREAGFRYGPSFRVVQEAWGNERESLGAL VLPDHLREGFPQFGLHPCLLDASLQSITGMQLDAGRDAPSMSIPFAMGQLEIFGPLPPVCYAHATLGSRR GEGAREIVKYNVAVLDEDGLVLARITDFSARAFTNDQPRSPAEQAAAPLGYYQSTWTRSAL DszB KR ACP KS5 DH KR ACP KS6 DH KR ACP KS7 DH KR ACP (KS8) ACP MSSTLRHTDTILVLLPASAAFSGLDERLVAQVSDPQRLVFVQAGERFASIDPRHYRVDPARPEDYVRLFS ELERSGALPTHILHAGNCVGPSALGAGERDAFASIRERLGQELERGLYAILSLVQAKLAVNPAGPTRCVF AFTTDEAHPRPHHEAVGGLAKALTTVDHRFQLVTVQMDACDADTAARRLIEELTSPHHQNGGEVRYRGGE RFVHEVQRLEPAPERGEPPAALPLRAGGVYLVTGGGGGLGMLFARHLAVKYGARLVLSGRAPLDDDKRAK LRELEALGGRAAYVPADVGDEAETRRLLSAVSAEFGELHGIFHCAGVADRTPLARATIADFERVLRPKVH GTLHLDLETRDRDLDVFVLFSSISALVGDFGAGSYSAANCFLDRFADAREQLRRSGLRRGQTLSVNWPLW QDGGMRMQEQDKAMYFQFSGMGALEAAEGIEAFEGALRAGRPQLLVVTGDRKKIDRILQVREPRSAAAPR EEPQRPAAGGAAPPAASHPGSSEGRGASGGERSSSAPQGSPRAATRGPLPREQLLAQCRDYLRNLIAQAT KLPVDKIHADRDLEDYGINSLMIMELNSMLDRDFDALPRTLFFEYKNVAELAAFFADEHGSRLQQILAGG TDSSPDATPPPEEQPPAPEPDAAAALAAAPAPAPRPPPAALRQDDGHIAVIGYGGRFPKADDPEAFWRIL KEGIDCITEIPRERWDWRAYHDDVPGTPGKIYCKWGGFINDFDRFDPLFFRLSPRAAHSMDPQERLFLTV AWETLEHAGYTLDRLNRGSDGPPGGAGRRNRVGVFAGVMWSDYGKHGQDELHKGNPVIASADYSSIANRV SYALNLHGPSIASDTACSSSLVAIHLACESLRRGECHYAIAGGVSLSLHPAKYLQMSNLKALSAEGKCRS FGAGGAGYVPGEGAGALLLKPLRQAIADGDYIHAVIRGTAVNHDGKTNGYTVPNPNAQADVISQALRQAG

VDARTISYVEAHGTGTELGDPIEVTGLSKSYRTDTKDRQFCALGSAKSNVGHLEGAAGVAGVIKVLLQMK HKQIAPSLHSRELNPSIDFASSPFKVPQELSAWERPRLARPDGAGEIPRRAGVSSFGAGGTNAHVILEEF ENAPRATSGREDVLVVLSARSEERLRAYAGKLAASLQLRLAGEDAAEHLDLERIAYTLQTGREAMDSRLA IIASDPRQLIADLEAYSEGRLDDKGPRCFSGTVKPYELPELEATHQAAIDEAAASYDLRALARQWIAGYA IDWPRLYPSPPPYPLALPTYPFARDRYWIPVAAQAPAVAAAAAKGLHPFLDANVSTLEELAFEKTFARGD LVLRDHVIAGRPVLPAAVYLEIARAAGHHAGPGPVSGVQDATWARPIVATGDSVTLRVSLARERQSVIYR VTSQPEGQPVVHGSGHLTFAAPAAAPPPASLRDIIARCPRQISADDLYRSFEALGIHYGPAFRPVQALHC GEREAVAVLRMPDAAGSGDYALNPSLLDGALQAIVHIGLDNELDPSLLRLPFALGRLVIRRPLDATSCHA HAILTHESRAGEDRVLKYRIDVYDGDGALLVEIVDYSVRVVARDALGPAGARASQPAHTLWYEPRWEATP AAPGRASAAWDRLPERLLVFGRDDELTSRLVEALSRLRPTRRIVPGAAFGALDRQGYRIDPADPSHYRRL SEELDRDDPWSTRTVGVIHLWRYPAGAEGAHAGLHSLLYLVQSLTARNAAQRVRCLVAVGSTDGAADPRD EALAGFGAALSPVNPHLELITLQADATRLDAQQMAGVLLHELAASDTAHGSEIRYTDAAARWTRALRPLE DGPTRTADAPPLRTGGVYVITGGSGYLGSTFARHLAGRYGARLVLCGRSSNDERKEALVRELRGLGGEAV YVQADVSDAGAAQRVVQAAQQRFGALHGILHAAGTDEAPPLARADAASFAKVLDPKVRGTLNLDAASRQV VTLDFFALFSSIAAVMGDLGAGCYAYANAFMDRFAAARERQRAQGRRHGKTLAINWPLWAGEGMSLPEGQ QELYAGIAGMRALDPALGLELFARALSAPAPQLLVVHGDPERMRRVIERRNPRPAAASSHPAEPAASAAP GDERLAQAVEDYLKGHFAAVFKMDAAQIDPQTSFDDYGIDSLVIVELHARLDKDMTPLPRTTFFELRTVR AVADHLLASRRAELRRVVGLDREATAPPAPEAGEPARRGGAEAPAHAVAPGPAASASSNEHAGAGAGRDA GSRAPARPGAALADEGIAIIGMSGRYPMAPDLDAFWANLKAGRDCVEEIPAERWDHRRYFDPEPGKEGKS YCAWGGFIEDVDKFDPLFFQISPKQVATMDPQERLFLETAWATLEHGGYGRVQEDAARIGVFAGVMWDDY GLLGLEQAALGNHVPAGSDHASIANRISFVMNLRGPSLTVSTACSSSLLAVHLAVESLRRGECAMAIAGG VNLSIHPSKYTRLCQLQMLAPDGRCRSFGAGGKGYVPGEGVGAVLLKPLSRAEADGDTIYAVIKGSAVNH GGKTHGYTVPSPKAQADVIGRALERAGVHARTISYVEAHGTGTALGDPIEVGGLEESFRRDTGDRQYCAL GSVKSNIGHLESAAGIAALTKVALQLHHRQIVPSLHAEVLNPNIHFESTPFYVQRTLDAWRQPEVREGGV TEVHPRRAGISSFGAGGTNVHMVVEEYQASTPALEIAAAEPELVVLSAHTEERLRAHAERLLRFLQGSRP GGLPSPSAPGRRLPEAAQLRAELRDIVARRLDVAPRDVDEDAEICELGLGALDVRRLTEDIERRFGLRVS PEDVTERTTVAGLAGRLRHLAAPDADRDDSAARPAVRLSDLAYTLRAGRDPRQHRLALHVADLDELIEQL RRYCEEGAADGSRCFAGQASRRAGSSGSRKEAMADEARVRAAIAERDLATLGRLWVAGTDVDWEPLDARR ARRRVPLPTYPFARERYWFSRSGDAFTLGQAGERRLHPLVQANTSTFHAHTYSSRLRGDAFYLADHLVHG QKLLPAAAFLEMARAAGEMASGRPVRDILDVVWTAPVVVGAEPREIEITLRPAAGAIDFAVSSAAERAVI SHAQGRMRLDEGDPAEEAAPPLPLDDILSRCSRVTGGDACYRRLQQLGLHHGGSMRALHELRRGEGEAIA EIRLPELHHVDFSTFALHPALLDAALQCTLGLLDDEAARAPYLPFAVGRVTLLRPLPARLFAYATPSSAP PGTNARASHVTLADPAGRVLLEMRDFTVRLATADVAPTPAQRLYFRPGLRPQRVDRPAGARAPQGPVLLL DTDDVLWTAARARLQAPIGLVLPGPEFQASSDDRYVIDPSRPEHHRRLLDAFVARHGVPASVLYLRSLHD DREAAGDTRHLDAVLHLCRALQERRGERSVRVLYVHPTEGGAVSPRHAALAAFARSVRREDPNLLCRTVA VPLDVGPGRLADALLAECSPDADRADPAAEVHYHEGQRLVRCFEPFQPDASRPVPLREEGVYVITGGAGG LGLILSDHLARRYRAKLVLCGRSPLSAQQASRVRALEASGAEVLVLRADVSQRDQASAALHEARSRFGRI DGVVHAAGALRDGLLSKKDPADVDAVISAKVTGTLLLDELTREDHLDFFLLCSSVAAILGSAGQADYAYG NAFMDAFAALREEQRHSGRRRGATLSVNWPLWQEGTMRPDAESIAWMTRATGMVPMDTEQGLAALEDCLR AGGPQIAVLAGDPGKIQALFSGERAAPAAGGPAALPPVEPGAYAPRAVGFLKRVFSEQWQLPIHRIDAEQ SLDQYGLDSIMAMSLTRRLETFFGELPKTLLFEHQTIAALAGYLARHHAEALRRVVGDSAPAVAPPPRPD AAPPGAAPAPRELSASRLPAPQPGGLDIAIVGLSGRYPMAPDLDAFWENLAAGRDCVVEIPADRWDHGRY FDPNPGAAGKSYSKWGGFLDDVDRFDPLFFNIAPREAEAMDPQERVFLEVAWHALEDAGYARSPLANRAT GVFVGVMYGHYQLFGAEALALDRPVSAGSSFASIANRVSYFFDFRGPSVALDTMCSSSLTAIHLACAALQ RGEIEMALAGGVNLSLHPQKYILLSRGKFMATDGRCRSFGEGGDGYVPGEGAGAVVLKRLDRAIADGDRI HGVVKASALNHGGKTSGYTVPNPSAQADVVAAALAQSGVDPRTITYVEAHGTGTSLGDPIEIAGLTRAFE ASPKERPTCAIGSVKSNVGHLESAAGVAGLTKVLLQMAHEQLVPSIHADPPNPNINFAESPFRVQRELGP WRAPVDERGQRLPLRAGLSSFGAGGANAHLVLEAYVPGDEAGAAAAVTAGSERPQVLVLSARTPERLRVS AARLLDHLRTRARGTALADVAYSLQVGREAMDARLALVVDSAEQAIALLEHHLGDRAPEGGAPRAQETQG LEHIHEGSARAGHVRQLVHGRAAASFLQALLDEGDLDRIAALWVSGCDVDWARLHEGARPRRVALPAYPF ARERCWFAVPAEDRRGGLPTSAEVAATARLHPLLSRNTSTFREQRFATTFTGEEILLSDHRIRGRALLPG TAYLEMARVAGELSAEGRVGRFTEVTWLQPIQVDRGPVEATLDLRPTETGCQFRVCTQDGALVHVRGQLH VEPQPPGGEPTVDLAAIKARCPEPLLRQDCYRALREQGFEYGPAFQVIEAFYDNDEEALALLSVAEPDFQ GFAGGLHPMILDAALHAGMLHRREGATGDVTPVPFYLEELVVLRPLERRCYAYMQVRRLAAGEERSEVAV MDVTLVDEAGSPLVRVKGFTGRKLVDADEEPEQNAVLFFGDAWQPAPLPSRPPAGAPPASVLLIAEDTAR ARAFERLVRARGGHLTWVCPVGSPRAQAEPSGAPSAGSGDRGAPGLAIEPRPVDDYRGLLATLKEQGRLP GGIIRLWDAPSLDTEASSPAEGPESVEELRELFHLVVALASAVPHPKARLILAFHGDPAPLAVEATSGFC RSLGLLLPGLRSSTIHWTHREPERHAEDLWAELADPATRGIGGRNGAEIRYRGPDRLARTAAPAALAPDA APAPLRHGGVYLIAGGAGGLGYLVAQHLAHRYRASLVLTGRSPLDAGKERQLAGLRDAGGQGLYCQADVA DEAAMAAAVRLAKERFGALHGVIHAAGVLDERPVVEKTWGEFHENLRPKVAGSAVLDRITAAEPLDFFAV FSSTSAVLGDFGSCDYGSGNRFQMAYGAHRERLRQQGLRRGITAVMNWPLWREGGMGGRAEWEQTYLKTS GLDYLDTAAGLEAFERILGARQSPVTVFYGKPSRVARALGLDAPPPPAGRGAAAAPLPPAEAPAAAPEAA VRESAARAPLREVILDAITEVLNVRRGAIAPDVNIAEYGFDSVSLAQLADQLGARLGLKLASLVFFEHTT VEEIEAFLERKHGAELRARMNGARELHGRMNEARELHDRMNGARELHDRMNEARELHDRMNGARKEAPRA

KEPAPADPAPPPAPRENGSRLAGAPRASAPRRPQEGASRGDIAIIGVSGRYPQAEDLRALWARLQAGESC IEEIPAERWDKDRYFDPQKGRSGKSESKWGGFLRDVDQFDPLLFNIPPARARIMDPMQRLFLESVYETLE DAGYTRAMLSKDGGKVGVYVGAIYHHYAMLAADESTRSLLLSAFGAHIANHVSHFFDLHGPCMAVDTTCA SSLTAIHLACEGLLLGRTDLAIAGGVNLSLIPEKYLGLSQLQFMSGGALSRPFGDSDGMIPGEGVGAVLL KPLDRAVRDRDHIHAIIRSSAVSHGGASTGFTAPNLKAQSDMFVEAIERAGIDPRTISYVEAAANGAPLG DPIEVNALTRAFRRFTADTGFCALGTVKSNIGHLEGASGVSQLAKVLLQLRHGALAPTINAEPRNPNLHL DDTPFYLQERLDDWRRPIISGREVPRRAMINSFGAGGGYATLVVEEHRPPPRDAAPGRSPSGPPELFVLS ARSRKSLRELVVRMRGFLAEATDLRLDDVAYTLQVGREALELRLAVVADTVEALLSALDGYLRDPEVPAP GVFTGQADGDASSGAAAPPAQALRTPEEAARRWVAGAAIDWEALYPLRDARRIPLPTYPFDRRRCWLDPA PSDEASPSPAAPPPEAPRPAAAPPAPPSAEARALEGYLCARLESTLGLDQGEISARASLRRLGLDSILAA KLKVTLEGELAMTIPMEVLSGDKSVAELGDYLSRRGARAPESRAKARSGAAGADLSTSLKALSGAVLREQ FLAFGHDLAGVPGEELTRLYAILQEE DszC CY CY A PCP OX (KS9) ACP (KS10) ACP TE MMTMESAMTIQEFANLSAEEKVQVLLRLRDRRASWQAAPEGPAASAQPSLRPVITARPGDRFLPFPLTPI QESFLVAKQVDRAGDHVGCHIYLEIDEARLDVARLERAFHRLVVHHDMLRTVVRADGTQQVQEPGQPRSF PVDDLRGRPGAALDAHLESVRASMSHRVYAPGAWPLHEIRITRCSDERSVIHVSIDEWILDAAGLNLLLT QWYRLYSDPDATLPVCDLSFRDYVLASREFERSPAYQGDLAYWCEKLAQMPGGPALPRAEQPGRPAGRAC YPRRRVHGRLAEAPWRALKDKARELDVSPTALLLTLFAEALASHSAPGPFSLTLTYFNRPPIHPHIERLL GPLISTHRFLVEGATDLTLQEEVQRSQRQLWRDMDHDRADSILALRALRARRAAPPASTVVFTSVLHNVS REARQQGRSFLDQITYSVTQTPQVYLDHQVYEKDGGLHFTWDVVDAVFAPGCVDALFDTYSRLLGALAAE PSRWTSPGWREELLGPRPPRGGGPDRTSAAPAGEGLEIIARPEERHQRFPLSDLQQAYFVGRTGFAANGG VSCQMYQEIELRDPDIVRLDRAWQRVIDAHEMLRAVIHADGTQSIRAEVPRYVIEVSDLRAASPEARAEA LARTRETMVARVFPLDQWPFFELRLSLTEPSRAVLHLSMDLLLADATSIHLVLKQLFALYERPDGPCAAP RLSFRDYQLALKDHERAAGHAVGVAYWRRRLADLPGGPELGMRLPDGRGGRLRRRQFDGVLERWSRLQEG AAALGVSAEAVLLGVYFEVLDGRSSRRPFTVVVARWDRPPVHPEIGAVVGDFTAVSWIVSPPGETFAERV RHLERTLSEDREHRLVSGSRVLQQMAIKSRNRQFLTFPVVFTGLGPSLKGDLPDTVSLGYRITQTPQVYL DNISMEADDALRLHWDSVEGVFPEGLIESMFGAYCRILDRLARDHAAWHEGRLDAPRAPEGPAPLPAPEG RDRAPGAARHRTTLHRLIEERASLCPDHVALIAEREQLTYRELNRRANQAARRLRRLGVGPDVLVGVLAD RSIEMVVALLAILKAGGAYVPIDPTYPRERIDFIAEDAGLSVLLLAEERRRLPSFRGTQLCLSTERHLLD GEAEHDLGPTAGPDHLAYVIYTSGSTGKPKGCMIPHDAICNRLLWMQDEYRLAPDDRVLQKTPYTFDVSV WEFFLPLIAGATLVMARPEGHKDVAYLVRVMEEQRITTCHFVPSMLNFFLKEPALPTHLRQVFTSGEALS YDVMDTFLRRSPARLHNLYGPTEAAVDVTYWPCERRPDRKVPIGRAISNVEIHILDSALRPVPAGAEGDL YIGGVCLARGYLNRPELSRERFVPSPFDPGARLYNTGDRARTLDDGNIEYLGRLDAQVKLRGFRIELGEI EAALSAHEAVQDAVVAVQDAHTEDPKLVAYLVTGGRPFPAPGALKAYLKERLPDYMVPNRFAPIAQIPVT AHGKLDRKALPWPVPAPSAQPEPPPAGAAAAPPGAAQARRPAGVSREAAEEELQRILGKALHLTRLDPGA DLFELGATSLTIVQASQHIEERFGVGLPVEVVLAEPTLDAIARHVAERTAAGAPEPPAPGPALDAPPAAP EPPAAAAPGPIDFFSREDRERFKQQQLHLRHGVEGLPTVDLADAPAAPRLYRDRGSRRDYRPEPVSFDDL SRLLAVLRRYPSGQQTQLCYPSAGGTYAVQTYLHVKEGAVERLPAGIYYYHPDRNQLVLINDRPAIRRVH HFYYNREHFDRAGFGLFFIAQTDAIQPIYGDQSLTFAAIEAGAMIQALMSHQAEADLGLCAMGGLDFDAI RADFKLGSGHRYIVCMLGGRVDREGGGRQGRARLLESAGADGSYGAAAAEAAAPRREREAPAGAREIAVI GLAGRYPGADTPRQLWRALRSGQSAVTRPPAGRFGASAPQGDEPRGGGASPGWGGYLERLDRFDSLFFGI SPAEAKLMDPQERLFIEVAWECLEDAGYTPEELRRAAPRVGVFVGAMWSDYQSVGLEAWQRDRRAKAVAF HSSIANRISYLFDLHGPSVAIDTSCSSGLTALHLASRSLRLGECDVALVGGVNLLGHPFHPDLLEGLNLT SRDDKTRAFGAGGSGWVPGEGVGAVLLRRLPEAEERGEHIRCVLKGTALAHAGKAPRYGMPSTRAQAGSI RDALADGGVAASEIDYVECAATGSGIADASEVDALKQAFEGRSPDGPPCLLGSVKPNIGHLESASALSQL TKVILQLEHGEIAPTLHTEPRNPLIQLDGTPFRINRALSPWPRAAGADAPPRRALINAFGATGSSAHAVV EEYRPRRRASTPAAAVPGLFVFVLSADTAEQLEACARALAEHLRERSTARPRDVAPPAAAADVAYTLQVG RRAMDERLAILAGDLDELEARLRGFLGGRGEDDGEHLFRGRASSPRDRAPLSPEAPLPALARAWVNGASI AWHDLYTDGSRRRVPLPTYPFARPSHWLGRPAGDAAAPAVARGETAEEAPSRGETAEEAPSRGETAEEAP SRETAEEAPAALAPATADPALRKATLGLLSSCFAEVAEIPRRSLDPEVPLDRYGLNSMLIAQLSARLEAL LGELPKTLLFEHHTLAALTDWLVAHRGDALLRRLDLPRRAAGPAASPGALPAAPAARRGPARERSAAASP ALAPAAPLESVDIAIVGLSGRYPGADTIDAFWSNLRQGRDSVTEVPADRWDAAAIFDPEGGPGKTRQRWG GFLDRVDRFDALLFNISPREAAGMDPQERLFLEIAWCAFEDAVYTRERLAEEQARAGVGAGVFVGSMYQQ YSMLARTPDAGASSSFWSIANRVSYFFDLRGPSLAVDTACASSLTALHLACESLRRGECCLALAGGVNLH LHPHKYVALDRLGLLGSGAASKSLGDGDGYVPGEAVGAVVLKPLDRAVADNDRIYGVIKGSFANHAGKTA GYGVPSPAAQADLIAAALRRTGIDPETIGYIEVAANGSSLGDAIELAGLTQAFRRFTARKHFCAVGSVKS NIGHPEAASGIAQLTKVLGQLHHRTLVPTLHAEPHNPNIDLRDSPFYVQRELGPWTAPTLAGEGGTAELP RRAAISSFGAGGANTHLLVEEYSPRPDDRGDEGAVPGAVIVPLSARTAGQLRAYAATLADDLERRSRPRG HGERALADRDLTAVAYTLQVGREAMNERSAIVTASLGDLITKLRQLAAGQTDVDDLHVGSAAASLSALML DGREGQAFLSILVEDGRHDKLARLWVSGARIDWRTLYGGSTPRPLSLPHYPFAGDRHWLDDEALPHGAAW SATAAPPAQTAAWSATAAPPARAADPGGAAPPEGPGGAPPGGAARQRIAQELTAMVCDVLKMQARDVDGD EALRNYGMDSRLSAAFMRSVQQRYGSSVPLSAAHTHPTLNQLTAHIHGLLSSNGAARHPSAAPLAATSPS IATAPAASAAPAASAAPAASAAPAASAAPAASAAPAASAASAVPAALHEAPAPDPRAGDARPGADSIAPQ

PEPGPNPDELVVINPRGSRGSSFWVHGAPGLAQPLYPLSAALGTDYPFFAFQARGVDGLAMPFTSIEEIA AHYVACLRQRSPRGPYVVGGLSSGGIIAFEMARQLLSQGERVSRLVMLDTYPAVAGLAQETPGDIDPILP LLLMANSFISFDRDGDTAIKPDDLAGLPPPMQLPRAVQLIKERSRTALSRDQIYRMLNGNIAVYKHLDLA CRKYQPGVLDAVDVLFFKAEKGFFGGANPLGLPILDVFSSYDYVTPWRQWIRGGLQVVELPCAHVDLLEP PALHQVVAHVREALS Geobacter uraniumreducens polyketide Gura_3098 KS1 KR ACP (KS2) MEQGEMEFTGMDIAIIGMSCRFPGAGNYEAFWDNLKQGRSGITEIPLERWDWRSFWGDPSEINKSNSKWGGFLQNVDSFDAEFFRISAREAETMDPQQRIMLELSWSCFEDAGVCPSQLSEKKIGVYLGVFNFDYKELQEKATRTIDTYHSTGTAAAVIANRISHYYHLKGPSLAIDTACSSSLNAIHSAAQSLSLGECSMALAGGISLLLTPTRHISFAKTGMLSPTGSCKSFDEAADGYVRSEGAGLVLLKPLKEALEDGDSICGVLKGSAVNHNGKTHTLTYPDPEAQAEVIVEAHRRAGTAPGNISYIEAHGTGTPKGDPLEFKGLVRAFSSLDSKPGEKVARTYCGIGSLKSNIGHSESAAGIAGVIKVLLSLKHKQLPGLQSFKKLNHRIEIEDSPFYIVDRFQEWKQLKGTDNQPLPRRAGVSGFGFGGTNAHVVLEEAPLVARPLAKKRPCYLICLSARTKEALLQRERDLASWLDREGDTNNLAEISATLLLRREHFGVRAAFLAGDIQELQGKLQEAVETGLSEMSLGGPEGKVKGELQPSVGESGNAILKELAQSKRVKVQEYKSKMQTLSELYAKGYDLDWQVLYPDNAAMPRINLPTYPFARQRHWLQPGIDEINPIKQAVEEQDPGRLALFLKKQWELCQLPAGRQSDRAVAILVTQETRCLANRISDYFPKSWLLDLHDLKADLQQPDRHWRRYDACVDLAGCGREIVETTTWISWLQRLIDSGHRDGLMLLCVTKGLESHDNAEINLSGAPRAGLYRMLQSEYSHVRSRHLDADPSSDDGTLAEQIATELTADCEDPEICYRKGNRYRAGLVEHSVQGGRKIIFPENHVLWITGGTRGLGYLCARHFLENYGVKRLVLTGREPLPSREEWDSYKGRQGGISEKIQAIQELERRGAQVCAISLPLTDERCVQKNLRQIKDSMGPVGGVIHCAGFADFENPAFIRKSIEGIQDVLDPKIIGLDILYRNLRNEPLQFFMLFSSVSAIVPVLGSGQSDYATANGYMDYFAEAKHAACPIVSIQWPSWKESGMGEIRSR VYQQTGLLAHTDQEGLWLMDAILSGEQGPVILPAVVDPGRWNPPALMRRAVQKTVQEKILSAPAPAESSTPGEGVIKTIQAWLIELFAKELRADPAKLDLDTPFQDYGADSILLAQILRQINRLTEDNLDPSLLLEHSSLGALGVWLAGAYSERLTSALGMAPEQNTDRTNRDAAPAPPLVPLTHAPTHESQPRSEHTRGTVSQDIAVIGLSCRFPGAETLDQYWSLLSQGRSAIRAVPRERWGYSNAFHAGLLDDITCFDPSFFLIPEEDAKAMDPQALAILEETLKAWCHAGYAPREIKGTSVGVYVGARSQHRPDLAVLEKARNPTLVGQNFMAANISHFFDLRGPSVVIDTACSSALLAMNMGIQALHSGDIDSALVGGVSLLNTDGYHRIFQQRNILSPEPHFHLFDRRSAGAVLGEGAGVLVLKTVERALQDGDAIHAVIKAVAVNNDGRTAGPATPNLQAQKEVMRTALERSGRGAEEISYLEANGSGTEVTDLLELKAIQSVYRAVGSTPLGLGSMKPNIGHPLCAEGIASFIKVVLMLQHRQFVPFLSGERPMEHYDLESSPFYFCRELREWTDQPQIAAINCFADGGTNAHVIVEVWRDTESRTKRQPLPAPVLSRIRIYQDGSSAPLAMQSREASFKHNCLAGNQTSVWKRGLVEV Gura_3097 DH ACP KS3 (DH) KR ACP KS4 DH ACP KS5 KR ACP (KS6) MQDQYRISSNHPIVRNHAAYGRKLLPGLAYIDMLYQLFRENGHDYAGLELRNLSIHNPLTIPDEDDLEIGIYCEEIKAGRWRIRVEGARSKSRPVETLFITAEMHRVDTPALEETQDLELIKKTADRVFSLGEVYERCRSFDLVHTGFMKAEGTVYQGEKGTLIDISLGDEALSSAEGFMFHPVLIDASAIGSGVVFDPLNKAARSLFLPLCYESFSAGALFKKRCLTLIQNPVSRKKEINYLTMTFFDESGRRIGELKNYAGKLVREAGLIDPFRKDVATSKGPIAPSGNGDMNRMSGTSSTRGSQAELFLQQLVAEKLGQPADQISTQVGYYEMGLNSPTLLEVVAVIGEKLSVQLMPTLLFEYTTIGELAEYLFLTYPDAFGKSPAAQTPSQKTQAASPVVSQPRPKAAPRIDAPSATRSDVAIIGMAGRYPKAKNLDEFWENLKAGMDCITEVPESRWELHRLHGIKSPSGKKMSEWGGFLDDPDCFDPQFFRISPREAEVLDPQERLFLETCWETIEDAGYTPSSLVASRGRHKRRDVGVFAGVMHKDYTLLEARAVDGGEVFPLSLSCALIANRVSYFCNFHGPSIAVDTVCSSSLIAVHLALESIKNGECEVALAGGVNLSLHPYKYLTYGVMDFHSSDGRCHTFGNGGDGYVSAEGVGAVLLKPLHKAIEDGDHIYAVISGSAINHVGAVSGVTVPSPIAHADMIETCVEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLARAYRIYTQDQQYCSIGSVKSNIGHAESAAGISGLHKLLLQLHHKVLVPSLHAEELNSYIDFKKSPFYVQRSLEQWRCPRITENGREVSYPRRAGLSSFGAYGSNAHIILEEYVPGAGRPAAAGYQQVQVLVPLSAKNEERLHAYAVRLLEFLDAPDGGLPRQAQGERESGLRKTMELRIRNIMSGIIHVREEDLEIEQDWNEYGVEFLQLELIKDALQDELAIEIDGADLRQWSSIAAASASLLEHRELLADSEDMPKLPQPASGRELNLTDLAFTLQVGREAMDARLAVVAQSIDELKEK LKGFVQGTEGVSGLFRGQVKRNKEIVDMFTSDDDMFNTVEAWMQKGMFHKLGKLWVNGMDVDWSRLYGEYRPQRIKLPTYPFARERYWVPDTGASRTDKGHRTGNAVHQIHPLLHQNTSNLSEQRFSSSFTGAEFFVNEPVGTGGKVLAAAACLEMVRAAVEEAAVTEEGGAGIRLKNVAWTRPIALNGQPVQVHIGLYLEDSGEIGFEIYSQAEGNQTEPLLHSRGTALLGPAGEAPRVDLEALQARCSRSALNAEQCYEAFRSMGIEYGLGQRGIESMHAGSEEALAKLMLPSGQSDTLERYVLHPSLLDCAFQATIGCGDAACRLALPASVESLELFAPCTSSMWAWARYSEGGGADNKAEAFDVDLCDETGRVCVRMKGIQYSGAETEPSFAADAISQLAQASATAAPEPFELMTFEEVWQEHALPNAPAAQLKKAICFLSDPQSQDLFAEAIPQTTVIFISQGTGYEKQSQSRYRVCLHDPKTYQEAFSSIREEHGDVDAVLYLWPLEDPERITDYASIVSTLHAVASAKLKTGRFLLAGRFGNELERCYLESWIGFERSLGLVLPTTQTAVLLEETTGRDLAAEMKTWAQRIRAEYAGGKVRSILYRDGKRYAYRIRPTLQEPGVSLVRAGGTYLITGGCGGLGFLFAADFARKNPVNLVLTGRSPLDEAKKSRIQALEDLGSKVWYLQADVCDVDAMKEGLNRAQERFGRIHGVIHSAGIEDIQSVLEKDMGRFEKVLAPKITGTLVLDELLREEPLDFICYFSSSAAILGDFGSCDYSIANRFQMSYTQYRNGLEKQGLRKGRAVAINWPLWKDGGMSIGDSEKTELYLKSSGQRTLETAEGLEVFERCLSVQDAAQHLVLVGQRSRVHRFLGLNEEVSRSNTVSAAPQLTGRSVEMQGLSVEQCLESDLKKQIATLMKIPISRVDEDTNLADFGFDSITLMELAALLTERFGIETTPSVFFAYSTLGKLVRYFASEHRAAIEELYREDAPKPAARAYVPAARHDIPAATQTQPQVRSKRRFGSIAASPGLSEPIAIVGMSG RFPQAGSVEEFWKNIVDGRVCITEVPSDRWDWRRYYTDRAQEAGKTNSRWGGFVPDVDCFDPLFFEISPKEAGFMDPGQRLFLEEAWHALEDAGYMGARIRGTACGVYVGVEEGEYGYLSGNQGLINSNQNATLSARIAYMLDLKGPNLALTAACSSGLVAVHQACQALRQGECEMALAGGISLLLSPSAYLGLSKFDMLSPDGTCRVFDRDANGLVPAEAVAAV

VLKPLSKAVADKDRIYGCIKASGVNYDGKTNGIIAPTPLSQAELIKSIYAKSRIAPDDIQYVLAHSTGSKLSDPIEFQALTSAFRSYTDKEQYCALGSIKPLVGHTFAASGLVNLIGMVMAMNTHTIPGMRHYETSNGYIRFEGSPFVPCRENQAWTSKNGGPRLGAISTTGINGTNAHAVIEEYIVPQNSAISVPASGPALFVLSAKTEVQLRSYAENIKSWIESHEDADLADIAYTLQMGREAMEYRLAFPAGSLDAVLRALTGFIGNDPSSGVFSGRVQEGKNEAGLFSSDENGKALLETWIQKARPAKIAEAWANGLNFDWSGVYGAETPRTISLPAYPFARERYWTPEAERLRLGDSGNDKIHPLLHQNTSDFSEQRFSSTFTGEEFFLTDHVVQGRKVLPGVAYLEMARAALEQAAGAEEGNAGVRLKNVVWARPIAVEGQPVRVHISLIPLDTGEITYEIYSDSQEDRAEPLVHGQGAAELLAACERSSLDIQALQAECTKESLTPSQCYETFKQMGIEYGPGHRGIEEAYVGEGKVLAKLSLSSSESDARGQFVFHPGLTDSALQPCLLLTSSGERKSVLPFAVRDVEIFSSCTSVTWSWVRLSDNGATGDKEKFDIDLCDETGLVCASLRGLSVRGVEGKTDSTGSSRGYAVVSDLDGNLHAAALAFEGNTVREKAEHYFKQLLSSAIGLPASRIETDAALEKYGIDSIMVLQMTNQLEKTFGSLPKTLFFEYRNIREVTSYFLASYPDQMKAALGIQEKPLVSHARLQHLAFVEGAAASPDKRGRSRLGSVRATSRNEKELAQGAFDIAVIGVSGRYPQAGDLQEFWKNLREGRDSITEIPKDRWDHGLYFDADKSILGKVYSKWGGFLDGVDLFDPLFFNISPREAQIIDPQERLFLECVYETMEDAGYTKENLSVNGKGGARGNVGVYVGVMYDEYQLYGAQEQIQGRPISCWGVSSSIANRVSYFCNFQGPSIAVDTMCSSSLTAIHFACHGIRRGECDVAIAGGVNVSIHPNKYLMLSQSGFLSSKGKCESFGKGGDGYVPGEGVGALLLKPVSKAIADGDHIYGVIKGTSINHGGKTNGYTVPNPQAQAGVVVGALQEAGIDPRSISYIEAHGTGTSLGDPIEIAGLTKAFREYTNDKEFCAIGSVKSNIGHCESAAGIAGVTKVLLQFAHGELAPSLHAQTLNPHIDFGDTPFVVQQELAEWKRPLIDGRELPRRAGISAFGAGGANAHVVMEEYQVEKKGLCTISKENPAVIVLSAKNDERLKERVKDLSEWVERAGYGDEKLADIAYTLQVGREEMEERLGFTVSTIQELEEKLNRYLKGEVDSFDLYRGQAKRDKETFSQFAIDEDLQKAVDNWISKRKYEKLLDFWVRGLSINWNKIYDREKPVRISLPAYPFAREKYWIPILKTEMNKRNKEYRREAMILTKEWQRTQIESDSVMNDVFLIILGTTNTTELATMIFKEKEGIQVIIVVQGTSVEKGIIATDFYVSDNGEELYRRIKEKGGESRLLGLIDITALDPKYEESLDLEAGKLRLLQKLIENDREKGFKLLQVTHLLNDFRNHAPSMQGARLAGLYRMLSAEYKEIRSATMDSDLGLNQNDIEKLESQIEKELMSSNKGKVTECCYRNEERYEPVLAVKMTEDEIRGAQTAIRYEQDDVILITGGTRGIGRAIAGRVVSQGVRKLVILGKEKLPPVEEWKNEAGRKEKIETLQSYVEVGVRVQYYDTPLTDEEAVNRMVTKVREELGEITGVFHCAGMAGKDPAFTRKPIGEIEDVCAPKIKGVVHLHQALRKEKLKFSILFSSVSSILPALSVGQSDYAMANSYMDYFAMSRTGEGNIKSVQWPAWREAGMVATTDGVKTPVYINSGLESISNREGMELLDVIREAGPNVSLPCVVNPERFKRNELLKTEIEVKKTELKPSRKTTKAVTWKKTVGKELNVEVREWLKEVFKQELRLNDAQLDETRPFDEYGVDSIVIAQIVQTLQKKISKPISPSVVLENKTLNELTKYFVDNHAQELKDLLGVEAEAVYEEVEEENDEYDNDYRVDFDSREEEIAIVGISCRFPDSPTKDAYWKLLTEGKKAIREVSESRWESNGRRDYGGWVDDIDSFDPEFFKLKENDAMIMDPQARLILEESLKAVYDAGYESKDITGQRVGVY VGGRAQVIPDMEKILEANNPILGIGQNYLATNISRFFNITGPSLVLDTACSSGLTAISMASDTLKRGRIDMAMVGAVSLILNQFTHRLFEARNILSKNGEFKIFENQSEGEVLGEGAGLVLMKRLSDAVRDGNKIYGVIKAIAVNNDGRTLGPGSPNIDAQKEVMKEALELSRKKPEEVDYIEVNGGGSPVVDTIEIKALSEIYRLDDNKLKPCAVGSIKPNIGHLLLTSGLAGFIRCMLSLEEKKIPPFLSAMEPFEHYDFTASRIGFNRECTDWLVAPGMKRIAAQNSFPDGGTNCHVIMEEFVPEGNYTQRLFSLPAPVLNKRTLGTGVTLSTATNRDSNEERETRDKAAHSSVHNVWGEFDAKYI Gura_3096 DH ACP DH KS7 MQNIFECNLTLDNPIVKGHQIFGRSVLPGLAYIDMLSQLAKEKLKIQRDDHCFKNLAIYNPLVVSNENPVRLRITFENVQRYWKISVESFENNATGPSKQRKLFVTVELHLNEVMPEELIDVETVKQASTKKYDLESIYSQASKVGLVHQGMIKAKGNIYVTSTGCLVDVNTEAANNEVAANYMFHPALLDGAAMSSMILIRERMPGSSQEEMYLPISYESFHGKGPLLDRCYVRIDRSLIRTVNDIATIDMDFFNPEGRLVAKLKGLTVKRVKDRDQMDPERVKVEKIERHEGVKTRDHYEGDEANVSCVTSLERALKKVFAKYINIQMDQLENSVGFFELGLESSQLLELVKDIEQSFQLALSPSLLFEYSNFLDLTKYLQKKLAEGGTQPQSFPSTKNVASTISSNKYKFYGSEPFLQDHLMYGRRAIIGLAYPCLAVESYLGNSYGGYPVELNDVRVSGGPIGLKKSENVEIEVKLNEQGAKLGFDVFKHATGESKPETVCSGFYQRNEHERLQRVDIKSIINKSKEVTSRRIGDPGQSCLIEAEWKYNGTTSIYHIKTAGSVNTGLQRTKIADSRLLKICYLLCDTDGLGKKVSVLEKIEKMTVFKRVADYAYVVKKVRIENPDSISYDAMVVTEGGDVVAEFINVQMQRVELPVLLKDLISETEGYEEKNARNSSIAIVGVSGRYPGARSLDEFWGNLKAGTDSITEIPEERWDWKQYFNEEKGKEGKIYSKWGGFISGADEFDPLFFNISPKEAESMDPQERLFLECAYHTLEDAGYTRERLNDQTKDRLGARVGVFAAVMYEEYQLYGAQDQKVGKNTALVGSPASIANRVSYSFNFHGPSMAVDSMCSSSLTALHLACLCIERGECDAAIAGGVNLSIHPNKYLVLSKGNFLSSQGRCESFGKGGDGYIPGEGVGAVLLKLLCKAEEDGDQIYGIIRGSMINSGGKTSGYTVPNPAAQGEVIREAIERAGFNARDISYIEAHGTGTSLGDPIEIAGLTRAFHQYTDETQFCAIGSVKSNIGHCESAAGISGLTKVLLQMKH KQLVPSIHAAELNPNIEFGSTPFKVQRELTDWNSETPRIAGISSFGAGGANAHVVIEEYVAEKKNPPTPSREHPALIVVSAKNEERLKERVRDLVEWLATSGPGDENLPDIAYTLQVGREAMEERLGFTASTILELRGKLNNYLKDETDSTDIYRGQAKRNKDASIRSATEEELQKAVRNWNSEKNHEKLLDTWVNGLSIDWDMIYVKEKPGKISLPGYPFARDKYWVAGMKGTKFERSHSVSQIHPLLHENISDLAEEFRWSST Gura_3095 DH KR ACP KS8 DH KR ACP KS9 DH KR ACP KS10 DH KR ACP KS11 KR ACP (KS12) MLKFRSCLKGNESFLKDHKINGKKILPGVAYLEMARAAVESALNLDKSQMQEIVLKNVAWLLPVVVEDNPVNLFVGVAANDNGEIDFEVCSTNVDGETVAHSYGSAEVTKAGETERIAISTMLEQRWLREVSSEEYYEAFGKMGIEYGPGHRGIERVYARDGEVLAKLSMPDCVKSESDHYVLHPSMLDSALQAAMGLIDGLGEVAVVPYAMERVEIKGKWHESMWAFARYGKGKKAAGRLESIDIDLCDHEGNVCVRMKGLAAREMSGEKDKDNRVILFHPEWKEEKASTAIPMEAYAEKIVVLYEPGPATEKEIVASLEGSRVITLRPGKDGVPIDERYENYTVGILEEIQGIVKRKPGRVLIQAVVFATGEGRLFAGHAALFKTARQEHPDIDWQMIELEDIEDAERVTKILKDNARSEAGKSIKYKAGNRSIAEMRELASAREIPRLPWKEKGVYLISGGVGGLGLIFARDIVENLKECTIILAGRSELTPDKESIIQGLKANGSIVKYYQADVTDNDQIE

SLIKEVVGKYGRVHGIIHSAGVIRDSYIVKKNRKDVEQVLRPKIKGLMAIEEAISGMELDVLLLFSSLAGVLGNAGQSDYAAANGFMDAYAQYRNELAEVGQRRGKALSLNWPLWKEGGMQVNPDAEKMMLQSWGMIPLQTSTGIRALYQGLASEKGQVLVMEGRLGRIRQKLDSLMTPAGAQPKTVPVASGTLSEIDSSSLQEKVLSILMQAVSELLRVKLADIDADVELNDYGFDSVSLTQFANTLNREYKLELAPTVFFEYPTLSRFAKYLVEAHSSAFSSSLGAQTNVQTKVQTKAAARAEEDRAEETTPGTRRHPRFAVTAAPAVAKPSASSFEPVAIVGLSGRFPFASDVDEFWKNLMDGRDCITEIPNSRWDWRRYYGDPAKEANKTNAKCGGFIDGVDEFDPLFFGISPREAEIMDPNQRLLMTHVWKAIEDAGYSAQSLSGTNTAIFAGTATSGYSELLSRAKVAIEAYSATGVAASVGPNRMSYFLNIHGPSEPIETACSSSLVAIHRAVAVLQD GTCEMAIAGGVNTIVSPELHLSFSKAGMLCEDGRCKTFSNRANGYARGEGVGVLFLKKLKDAERDNDHVHAVIRGTAENHGGRANSLTAPNPVAQADLLTSAYTTAGIDPRTVGYIEAHGTGTELGDPIEINGLKAAFKELYRATGEPEVTSAHCGLGSVKTNIGHLELAAGIAGVIKVIQQLKYKTLAKSLHCDVVNPYIQLENSPFYIVQENREWKALRDGNGNELPRRAGVSSFGFGGANAHVVIEEYVPKDQPHVAIAPPNPAIIVLSAKNEERLKEQAQLLVAAIRERQFSDADLVNIAYTLQVGRDAMEERLALIPQSVQELSEALTKYCEGREGIEKLYRGQVKPNKEALSVFSMDEELQEAIEKWMERGKYSRLLGLWVRGQQFDWNKLYRDPKPRRVSLPTYPFTKERYWVPETREQKPEYQEQRIHPLLHQNASDFSEQRFSSTFTGEEFFLTDHVVRGRKVLPGVAYLEMARAALEQAAGAEEPKAGIRLKNVVWARPIAVDAQPVRVHIGLVPNDTGEITYEIYSDSQANGAEPLVHGQGAAEFLSTRETSTLDIEALQAECTQESLSSSQCYEAFLQMGFEYGPGHRGIVEAYVGVGQVLAKLSLPDSVSQTDGQYVLHPSLMDSALQASIGLIRGQDQGGALKPVVPFALQELDVLGTCTPSMWTLIRYGKGSKPGDSVQQLDIDVSDEHGKVRVTMRGLSLKGLDGEVRPGASTAIGTVMLEPVWNEQSVAEEATAADQAEHLVLLCGQDDLTHEEVTRLMSGARCISFHSEQKGIGERFGDYALQAFQEIQSVLRSKSKGKLLVQVVFSGQGDGQLFGGLSGLLKTARLENPNFGWQLIEVETRETSESIVEKLKGNSRSALDQQIRYQGGKRFVCGWREVASFQEQASIPWRDRGVYLITGGAGNLGLIFAKEIANRVTGATLILTGRSPLSEVKRAQLRELEASGARVEYQQVDVSQKDAVAGLIQALVEEFGSINGIIHAAGVTRDSFIIKKTNEEFLEVLGPKVGGLVHLDQASQHLELDLVLLFSSAAA AAGNLGQADYAAANAFMDAYAAYRNDLVARNERRGRTFSINWPLWQEGGMQVDAETRQMMLQTRGMIPLPTATGIAALYQALACGKNQIMVIDGDPQRVTAGIIAQPSRAELRKDVSPVVENGVAPEVTQDSLRDKASDYFKKLVAAGIKLPAHRVDVDAPMERYGIDSIMVLQLTNELEKVFGSLPKTLFFEYQTIQALSGYFLESHRDQLMGLLEIEQTPTAAADTSQNSVAAPKPAQPVASNRRPSRFASRAAAREEKANEVSDIAIIGVSGRYPGAGNLGEFWKNLRDGKDCITEIPKDRWDHSLYFDADKNKQGKTNSKWGGFLDGVDLFDTLFFNISPREAEIMDPQERLFLQCVYETLENAGYTREALGLHQGGGLEGNVGVYVGVMYEEYQLYGAQETAKGRPLALAGNPSSIANRVSYFCNFHGPSMAVDTMCSSSLTAIHLACQSLQRGGCEVAIAGGVNVSVHPNKYMFLGQGKFVSSKGRCESFGEGGDGYVPGEGVGAVLLKPLAKAVADGDQIYGVIKASTINHGGKTNGYTVPNPNAQASVIGRALQQSGVHPRTISYIEAHGTGTSLGDPIEIAGLAKTFQEHTKEKQFCSIGSAKSNIGHCESAAGIAGVTKVLLQLKHRQLAPSLHSEVLNPNIDFSTTPFVVQQQLAEWKRPVVEINGQTREYPRIAGISSFGAGGSNAHVVIEEYIPEGGERIPVRVSAQHPAIVVLSAKNEKRLEEQARRLLGAIQERQFSDADLADAAYTLQVGREAMDARLAMVVASIKDLEEKLSGYLDGKSDLEHLHKGHVKRDRDNDSAWLYAVDEDMAKTIDAWVSKGKYARLLDLWVKGLNFDWNRLYGAAKPHRISLPTYPFAGDRYWVPEIAQTAGASALLPVAHSIHPLLHQNTSDLTEQRFSSIFTGEEFFLADHAVSGEKILPVAAYLEMARAAVDRAAGSWNPSQKGISLKNIVWARPITVTGQPVQVHVGLFPKDNGEIGYEIYSESTEHSAETIINSQGSALFGPVADIPVINLLDVQSECDRELSSAQCYDAF KTMGSEYGARHRGIERAYAGSTTVLAKLSLPSSISETEDHYLLHPSMLDSAMQASLLIVGEPASMAAPKPMVPSTLHQLEILQRCTSLMWAVIRSGNSGEAAGRANNVDVDLCDENGSVCVRMRGLSFRVLEGGQGTVGAAADQETLVLKPVWEAPADVKEGRAPEYAGHLVILCQMSNVLKEGVEVQMDGVRSLIISSEEREMEKRFPVYAQQVFEQIQSLLNEKPKGKVLVQMVIPNNGEGNLLAALNGVLKTAHQENPKLTGQLIAVDSTEDADKTVEKLKYNSRCPADDRVRYEEGKRQVVRWKEIGVSQASVGMQWKEQGVYLITGGAGGLGFIFAKELARKANGITLILTGRSAHGDAKQALLQELESLGARAQYRQTDVTERNSVEQLVKSIVDDHGNLNGIIHSAGVNKDNFIIKKTVEEFHEVLSPKVAGLVNLDYASKDLGLDFFVLFSSVAGAFGSPGQADYSTANAFMDCYAAQRNALVQKGERFGATLSINWPLWREGGMQVDAETEKMMQHKLGLRPLPSLAGIQAFHTGLVAGFDQTLVLHGNRARIQEQLLDTISELPSSPGDELILQADSLVLKEKVVYQLKVLLGRVVKLSAHRIDAHEPLESYGIDSIMITQLNQELAKIFGELSKTLFYEYQDLDALAAYFITGYPQRCLQWTGLRDSIPTGQKASAEDLHQDGDFPVLTSFKIAKTSRRSFSGTQENHGNREPIAIIGMSGRYPQADNLGDYWENLKAGRDCITEIPEDRWPLDGFYHADPQEAVEMRKSYSKWGGFVRGFADFDPLFFNISALDAINTDPQERLFIQSCWEVFEDAGYTREQLAAQFKGRVGVFAGITKNGFALYGPDLWRQGETISPRTSFSSVANRVSYLFNLRGPSMAVDTMCSASLTAIHEACEHLHHKECEMAIAGGVNLYLHPASYVELCALQMLSTDGQCKSFGLDGNGFVPGEGVGVVLLKPLSRAIADRDQIHAVIRGSRTNHGGKTNGYTVPSPVAQGELIRETLDKAGIHARAVSYIEAHGTGTKLGDPIEITGLAQ AFHKDTADTGYCAIGSVKSNIGHLEAAAGIAGVTKIVLQMKHRSHVPSLHSVNLNPNIDFAKTPFTVQQELSEWVRPVVEIDGETREYPRIAGISSFGAGGSNAHVILEEYAPGDEERTRVAINAQHPALIVLSARDGERLRASVERLLGAQSSQRFTDADLADVAYTLQIGREAMEERMALIVATVSELEQKLKDYLNGKDDIEGLSMGQVKRDNDMLAVFTADDDMQEAIGKWIRKRKYSKVLDLWVQGIPVDWNVLYGDSTPRRISLPAYPFAGERYWLPEIKGQRLDAAGQGAPGSGNALHPLLHQNTSDLTEQRFSSTFTGQEFFLSDHVVRGERVFPGVAYLEMARAAVDRAAGGLKQALTGISLKHVVWARPIIVNDRPVQVHIGLFPEDNGEIGYEVYSESPEAGTVVHSQGQAKLLPSSGKSTLDISALRAACNLGTLTPAQCYGGFRAMGIEYGSGHRGIEHIFVGANQALAKLSLPSSVCQTVDQFVLHPSIMDSAFQACAGLMDSFGSQAASGSAPSKPILPFALQELEILGRCSSSMWALIRYGNGSKPGDAVQKIDITVCDEHGNVQVVIKGLSLRSLEGEVPSVGASASIGTLMLEPVWNEQALAEIATAPDLATHLVLLCGLENGIPEAVTSQMSGTRCVALQSEQKGIEERFTDHAARLFAELQGILREKHRGSVLVQVVLPADPEGLLFTGLLGLLKSARMENPRLIGQLIEVEARETSESIVEKLNQNSHDPLATHIRYRDGKRFVAGLSELEVPGAEENIPWKEGGVYLITGGAGGLGMIFAGEIAHKVRSVTLVLTGRSSLNDERRSRLKELEGAGARIVYKEVDVTRREAVAELIQNIMKEFGTLTGIIHAAGVVRDNFIIKKTQEELLEVLAPKVMGLVNLDQETKHLNQDLFILFSSGAGLLGNIGQADYAAANAFMDAYAAYRNGLVARNERLGRTFSINWPLWQEGGMRIDAKTESMSLQRTGMISLQTQTGIRALYQCLACGRDQVMPLEGDVERLRAVLLDRQDATETSTLSCAAEEGKTVP

AVAQDLLQEKATDYLKKLISSVIKYPASKIDANAPMEKYGIDSIMVMQLTNQLEKAFGSLPKTLFFEYQTIQALSGYFLESHRDQLMGLLEIEQKPTTAADSSQNSVAAPKSVQTAALNRRQARFACRAESQEEKANEESDIAIIGVSGRYPGAENIGEFWKNLRDGKDCITEIPKERWDHSLYFDADKNKKGKTYSKWGGFLDGVDRFDTLFFNITPREAEILDPQERLFLQCVYETLENAGYTREVLGTGLDGNVGVYVGVMYEEYQLYGAQETALGRPLALSGSPSSIANRVSYFCNFHGPSMAVDTMCSSSLTAIHLACQSLQRGGCEVAIAGGVNVSVHPNKYMFLGQGKFVSSKGRCESFGEGGDGYVPGEGVGAVLLKPLAKAVADGDQIYGVIKASTINHGGKTNGYTVPNPNAQASVIGRALQQSGVHPRTISYIEAHGTGTSLGDPIEIAGLAKTFQEHTKEKQFCSIGSAKSNIGHCESAAGIAGVTKVLLQLKHRQLAPSLHSEVLNPNIDFSTTPFVVQQQLAEWKRPVVEINGQTREYPRIAGISSFGAGGSNAHVVIEEYIPEGGERIPVRVSAQHPAIVVLSAKNEKRLEEQARRLLGAIQERQFSDADLADAAYTLQVGREAMDARLALVVASIKELEEKLSGFLDGTNDIEDLYKGNVKRDNDSAWLYAVDEDMAKTIDAWVSKGKYARLLELWVKGMHFDWNRLYGAAKPRRIGLPTYPFAGERYWVPEMAQSSVAGVAPAVVSDSQRERVILIKDWQQKNAGAASDIPSGLIIVLGTAATAELAAELFSQRTDIRAIHVVHDALSSSDAIPTDFYSASAGEDLYHQIRERRLNRKLLGVIDLTAYDSEYERSVAVESGKIAFLQKLIEYDRSERFTLLQVTHALHAFHLATTTLQGARLAGLYRMLGSEYKQILSLTMDSDCPLAMKEKLAAQIKNEFANTCQEHVSESCYRNDRRYEPQLRIGQTDVDIEKNYPETERYRSVDVILITGGSRGIGASIAEHLVSQGCRNLAILGREALPEQSEWKTVLE RNDMPEMSEKLRRMQSFVEQGVRVRYYTTPLTDQDGLRDMVDDIHRHAGPLTGIFHCAGVTGKKPVFFNKTYSEIESVCEPKMTGLATLHKVVETEPLAFFILFSSISSVAPTLSTSQSDYAMANAYMDYFAEYQASHGHAYVKSIQWPAWGETGMAANGQQTPAYKKTGLALVSTANGLMLLDVIKNGSYRVSLPCVVIPHEFRHDQLLKTTLKVDLQPARAVSAAPQLPPAHRLTAGVKESVRQWLRNTFMTELKLTADQLDEDTSFDDYGIDSIMFAQLVQTLEKGVQGKLDPALLFEHTTLAALTDYFSAHHADQFQADLAASTPAEAALSEDSTAQMKEPAFEGLGGNEPIARNEIVTAPEDIAVVGISCRFPDSPTKEAYWELLAKGEKAIREVPENRWESNGRRDYGGWIDDIDMFDPEFFKLKENDAMIMDPQARVVLEEGLKAIYDAGYESKDVSGQRVGVYLGGRAQITQDIEKVLEATNPILGLGQNYLATNISRFLNITGPSLVVDTACSSGLTAISMASDTLKNGRIDMAMAGAVNLILNPFTHRLFEARKILSKNGDFKIFEKQAGGEVLGEGAGVVVLKRLSDAVRDGNKIYGVIKAIAVNNDGRTLGPGSPNMETQKQVMKEALELSGKTPEDIGYIEVNGGGSPVVDSIEIRALSEIYRLDDKKMKSCVVGSIKPNIGHLLLTSGLAGFIRCMLSLEEKKIPPFLSALEPFEHYDFTASRIAFNRECSDWLIESGRKRIAAQNSFPDGGTNCHVIMEEFVPEVNYTQRLFSLAAPAMNKRSFASSRTVTFQQDSLVKSTNEDSIDDFIDRFKSIDNQMINLEAVQSSVKNVWGEFDEKNI Gura_3094 DH ACP DH (KS13) MKKIFNFQLTLDNPIVKSHQVYGHSVLPGLAYIDMLYQLAKDGLNLSSDDHCLKRLAIYKPLVVSKEKPVRVKITFERKQRNWKISVAGVETDIHKESQAGMLYVTAELQKKVDFLEEVIDVEAVKQLSTKTYDMETTYSEARKAGLVHQGMIKATGNVYITDSGCLIDVNANLANQDTAQNYLFHPALMDGAAMSSMILIREGMPDSIADLYLPLSYETFYSKGPLLDRCYVRIERSSIRTVNDITTVDMDFFDTGGHLTAKLSGLTIKLVKDPSQIDPERVKAEQAERDDNISSPVHEDGGNVRHASLPSVEEPLKKIFAKYVNTNMDQLENLGFLELGMESSQLLELVKDIEEQFELSLSPSLLFEYSNFIALAGYLEKKLAEGGTKSQNWSTESGTLTIPSDKYEFYGSEPFLQDHQVYARPAIMGVTYPCLAIETYLKNNPEGYPLGLRNIRFYGGPVGLNKNETVEVEVKSKGVNGFETLFGTSNKERNCAGDFIGTVDSIPERLEIQSIVSQSKMFAPGTIEKIYKMIHDIKIEKTLKTIEALYAYDKVTLVAKITMAGSQKRGNSENLVFDPLLLNSCYLMADPVTVDPEIKVPLSIDSITVYRPTTEIAYVIKKIRVEKSDYISFDAIVVTETGEMIAKILNATLQKVGSSVQLKNLDPVLNGNIEKKKGPADIAIIGVSVRYPGASHINEFWNNLKEGKSNITEIPQERWNWREYFDKEKGKAGKMYSKWGGFLEDIDKFDHQFFNISPREAQIMDPQERLFLQETYSCIENAGYTPDTICDSRKIGVFVGVMNADYFKGSHPFVIANRVSYTYNFQGPSMVVNSASSSSLTAVHLALDSLHSGACDRAIAGGVNLILSPNHYTILSALGVLSATDRCSAFGAEADGFVTGEGVGAVLLKPLAQAINDGDNIYGIIKGSMINNGGRTNAFMAPNPVSQGQVIREAIERSGVNARSISYIEANGTGTPLGDPVEISGLTKAFQHHTDDKQFCAIGSVNSNIGHCECAIGIAALTKVLLQMKHGKIVPSLFAENLNPHIDFE NTPFVVQRELTEWKSDAPRIAGVSSFGAGGSNAHVVVAEFVGKDDDSCNVSEGTPAIFVVSAQNAERLNERVKDLIEWLEGETFGDERLMQVAYTLQVGREAMKSRLGFTAKTNKEAIEKLTCYLNRENNNARIFFGQAKKHSKMPSATPADGKEQEAVHKWMSSRNYEKLAALWVKGSVIDWNKLYEGKKPRRISLPSYPFAQESHWMVMP Lankacidin pSLA2-L_p018 C A PCP KS MTERQASAYERFQWYRYQRNPDDPGLTVGYVYALTGEVDTDRLEDALREVVSTAFPRLLDYFTEVGGELI AKSRPLPRRILRRCERQDVLLDSGGIDPTGQELFRFRYCRVSPQKLLLRLDFSHVVFDGGCYAPFCAALS ACWEGETPVLERQFGAAPRSGDGADAAYWRSMLAGRPLHQPLPFSAAEPRRDGRRISVKETITGDQAEDI HRFLRRHELSLLQFVVGVTGALVHAYGDDDERGVVVAHTVDTRPYGAPYGCHTNLLPLWLDVRAERDALS LLEQVRAQRENLRDHQGFPVSDLLALAAGEHGRTVDQGGSALNLVVNASSAMLPTAVPRLSGLDVSWVRK PDTGSSSDLSVNFSSDEQGIHLSFDSATHVLSPEALSALAANFLRMARFVAADPHRPTAQCDLSRPLEPV AEGAVPAAGTGEGLGAALVRTARQNPDRVAVVDDHRSLTYGELLDAAHRLGQDLFGDATPARPGTAPVGV FLERSAAIPVAYLTALALRRTFVPMDPRLPDARLAYMAAAAEPGVILVDAATRDRAARLFPGIPRREVDG APAPSAGPHRAGIRPSTPADGDRTAYVMFTSGSTGNPKGVAVSEGNLANFLHSVRQDPSMGPDDRIVALT PIGFDISLLEILLPLLCGARLRMLSDETRSSGALLAEHIDAAGATVVQATPSTWRILKAAGWRARRPMTL LCGGEALDRDLAEYLLSQSAAVYNMYGPTEATIWASWQRVTGAGHIHLGEPALGTRFYVVDADGRSVAPG MAGELMIAGDCVAQGYLNAPATAFGSLPDGTPSYRTGDLVRYEGPARVTYVSRKDGQRKVNGHRIELDEV AAAVTARVPSATVVAVVRPEPEPHLRCFVWLPAGESFDAAAVRERLRDTLPYYMVPQAVHRLTRIPLTAN GKTDVRKLSEAPLSALDLYPQDEASERPADAARAAVDTGAAGGPDTGAADGPDLLGELRRLVAAELGLPE PDADRPLGYQGVTSLGYNILAARIGERYGITVHAHDFYRMNTLRNVAETVARLSEGRTGERPEARPATAP RPGPADGRPGADGRLAIVGLSAVLPGGPDPDAFWQTLLDGRDCVTPAPAGRGLPGEFAGFLPGVRGFDAR

FFSISPREASWMDPRQRLLLQSAWHTLEDAGYAPSDLSGSRTGCYIAATGNDYALLQARADARQIPYSLV GHSLSLIANRVSSWFDWHGPSAVLDTACSGSLVALVRACRDLRAGVCDAALVGGVNLILDSQINEGLHAA RFLSPEHRCATFDAAADGYVRGEGYGTFLVKRLADALADGDDIRAVVESVAENHGGRANSLTAPNPNAQY RLLLDAYTPELAARTGYIETHGTGTALGDAIEIDALKRAWRHLVPRSAGGRVRLGAVKSHIGHLEPAAGV ASLTKVVKAFEHRTLPANLHFQDPNPGIALEEGPFEAVRKTVPWGEDGGELVAGISSFGFGGSNAHVVLS APPGRAARRPVSPRPRLVPLSARTPQALRRLTAALLDRVERSGPLSDHDLLDLSYTLCRREHLPCRLAWC PSSGEELLRALRTAGEPRHAPRTEREGGVWQATPESARDRFLAGGPVDTQALFAADAPRRLRLPGYPFEE TDLWFTDEERTA pSLA2-L_p017 DH MTTRADQTAGPAAVEPPRLLDTGEPDTFRVPVETGHPYLAQHLVQGRRVLPGVACLEMALRGAARVRPGA RPFAVRDAAWLRPVYGDEPLDELSVAFRTAPGARETDYTVTNRGALCAMGTLLFEPQDRAVAVGLEVRDE ICAHTRSHLTRAEIYEEFSNMGIDYGPYFRRNSYVQRHGQRSLAWLSHNDGTRIGLVNLLDCAFQSGMAI SIGEHRDSLMPFSMGHMVFHAPTRFPLGSAFVLTEKLSPFRTNFTLFDEDYEPLLSVFDLGVKPAL pSLA2-L_p016 KR MT ACP KS DH MSRNEWRSGDSASGTARPDVPLVRRAAVDSMVFAPQWTHGRLERPRTGGDGPRTFLVPPGQHRLHQELTE QCPDSRVLLLDDAAIASLAAAPAADEHLVFVSRTSWADGIRDADLTAFLGLVHALDRWPRVRLDVFTDKA VPSPLFTAATHPVDGVYVGLAQALAKERPDWSVRCFCLADLTAAALSEALERPLPTVPDKPVCVRGDEYA VASMEPASLPAWPARSAFRTGGTYVIVGGTGGLGGLLAEYLAAVHRAEVVVIGRRPAEDFAPAAQALREA GARAVHYHQADLADGPALKRALDAHEVVHGVVHSALVLEDSALATMSERVLHDVLRPKLHGTRHLIEALR GRDLDFCLFFSSVQAYIASAGQGNYAAACVAKDACADLLDHALLIDAKVVNWGYWGGIGVVAKPEYRARM EGLGIGSIEPAEGLAVIERFLASEHRRITCVKGTEEALERMGITPHKPAATVSSADSATVLDDVVPAFRD EDTDVAHNRDLAERLEAYTRWRLAQVPLPATAIAKYAKLREAIAAMPPAHSLPLDELLRRYPELEGHCKL LDRCLKHLPDVLSGATDAVEVLFPDGSFELVAPVYQSNPIADYFNRICARVVAAYQRRSAGRPLRVLEIG AGTGSTTGFVLPELDPHGVDYHFTDLSYAFLHKARDAFGADYPFLTYEICDIENPPEDYTGRFDVVVATN VLHATSNVPGTLRNVRKALREGGILVLNEITARQDYATLTFGLTDGWWLSNDPYRIEHSPLLSSDQWRSL MHEAGFGAVRPHGGDGQQVLVALAGPADEPSAAVPAPEAAGAVGVRGAVEGFVREVIAGTMRLDVSEVEC DRPFRDMGIDSLISMELLKPLRERVGYVPATVWFEYPTVDRLVEFLVTEYADAVAESFGAATATATAAVP ASEAAGAVGVRGAVEGFVREVIAGTMRLDVSEVECDRPFRDMGIDSLISMELLKPLRERVGYVPATVWFE YPTVDRLVEFLVTEYADAVAESFGATAATATAEEPVRPEQTEATAPAGQTALNQGEFAPRPGDIAVVGIA ARLPQASDVRQFWENLLDGLDCTSTVPPERFATRLTDGAAPLSYTDRGAFVDDIDAFDHTFFGLTPHDAA RMDPQERLVLEQTYLAMLDAGYSRARLAGSDTGVFVGVMNGGYAWHTTTEPGAQPPTSAFWSMANRASYH FDWHGPSMAVDTACSASLTALHLACQSLRTGECDRAVVSGVNLITHPRQYQLLCGLEMLSRAGECRPFGS GADGFVDGEGVISLMLRPAEDALRDGDRVYAVISGSAVNAGGRANGYTAPNPEAQSALVAKALAAARTSP EEVGYVEAHGTGTALGDPIELRSLAKAYAAAGTGRIRLGSVKSNIGHLESAAGLSGVLKAVLQMRHGSLV PSLHAEPPNPHLDFDATPFTLAARTERWPADLPLVSAVSSYGAGGANAHVVLRGVPEPPAPAANATPRRD RYVIPLSHHTAAGLQLAMDGLREWLSGRRVDMDALAYTLACCRDSFAHRVAIVCRDQDELVRALERDLPR RPRRRTAPAPAAAELTSRTAEDIAALYESGGTPDWDRYYPRTTPVELPAYPFLRHRHWVDSAESGFRSLA TLVSAHRIDGVAMAPAAWTLAVLADRAEGRALGNVLWQKPITDPGALEVRERGGEMSLVDRVTGDVYCTA EAGAPTPVGNPPDLPAATRRQSRTEIYDAFRRLGYDYGEPLRGVRWAEVGPDTVRAFLHVDHDWGYGLSP ALLDCGMQLSILLAAERTPDAPVFVPCHLGRLTVVRAPRTEAVYCHCVTRPGGSSPRTRTYDFFFTDENG DVLVALEEAVSVAIDGSAPAATRHGAPAPAPAAAPFTVLELN pSLA2-L_p013 KR ACP KS KR ACP KS MESLAPRYTDLAASDLPGAQAGATVVITDRQDIASAARSIGAECWHCDPATESDERIGRELGRYAARCTT LVVAWGDGHADGTPEYDAALRFARAGLALLQAVRGSGRPVRLVTLSRTGDTLPALLDGMARTAALECPLV HTAVEWSGTVTPRRLRAWIDAGAGRPGAVLRAEDDRIGLLEHTPRPLEGTGAREVFGDGDSVVVIGGAGG IGRQLCRYLSRHCGVRVFVLGRGTPGPRVREALKEAGVHSHLGAPADDPEALDGALRYLHDRFGPVKAVF NLAGVLDDCLLYHLTPDRLEHVLRPKVATGLNLAALTGPHRPGMVVHFSSLTSVTGNVGQAAYAAANAFL DRLSAHRPDWYSINWGLWDTDGMRMPDDDGSGLRAMPPEQACDTLLRALATGTRQLVVYDGQPGLLATGT GAPDPSAPPRGAADAPAAGSRDGGPSADGLLVGTTRWLRELIVRHSGLRGLRDDENLLEQGLDSVGSIRV SRDIESCLGIAGSSRLSRAVLFEYPTVAALAAHLAETFAPELETFLTREDSPSPQPTAPPESAPPPESAA SPEPVPAPAVRAAGTPPRPAGRQRASAPAAARSEDAPAADAYRPDDIAVIGMAGEFPGGADTEAFWQALL RGDDAVRVIPGDRWDWRENHSFAPDEPGTAYGRHGGFLDHALDFDPVFFNIAPLEARFMDPQERRFLQSV YHALEDAGYFARPTGDMGVFVAAMFGHYQDLTAADRVIGSSFAAIANRVSYAFDLHGPSIALDTMCSGGL TALHLAVRSIRAGDCALAVAGGVNLMTHPGKYRLLSEGRFLSPTGHCQAFGVEADGYVPGEGTAAVVLKP LSDALRDGDRVHAVIRATAVNSGGRTAGFTVPSERAQHRVIAAALAEAEIEPGAVTYVEAHGTGTRLGDP IEVRALSRAYGGPEQGRAYLGSVKSNIGHLESAAAMAGLVKVVKQLAHRTLAPTLHCTLENPDLHLADSR FALVKETLPWPKGSGPTRFAGLSSFGAGGANGHAIVQEFVAPPDTAPVPAFPCYFIALSGRDEAAVQRRA DQLLAALRDAPDTASYLYGLSYTLCCARQHFRVRRGYWATSVAQLAERLEHAAGAAPAAPPADDAWAEAA AAYLAGERADFAALFPRPMLVDAPLYPFARERYVAETLDHANRPPARTAPAAPQAGPAGDDTLLLTPVWR PHPAEEPAGAPPPCVLVLTDRGPRPPLPEPPAGLRLIRVTPGDTLVIEADRIELPEGDDTAARRALDHLT GDLGLDHLYWLDLRREVTAAAQLSFAKAVQGCRTPSTVLGVTRESEAAEARAWAGFLHGLAEENPHVRTV

QARRAGDGPALADGWGPLLDELRAARRPLTEVRWADGTRYTRELTELRLADGQRAGVRLRTGGTYLVTGG LGKVGRAITELLAERYRATVIAVGRSAPDAAQRQWIAGTPGLHYEQADVTSAARTRELVDTVRARFGGID GVVHCAGVVRDALVQNKSAGDAEAVLAPKLRGTLNLDRCTADLPLDFFCVFSSISSVMGNTGQSDYIAAN RFLDEFAAERARRVAAGERGGLSLSVNWPLWLDAEDERREQYQALAAFLRGQFGMEPLSARRGAQLFLDL VDGLPATCHQVVPCVGDLARMRQRLLPGAAPAAARPAPRPGATQEELGARLLELVRAQTGLSAEDIAFDS RWGDLGYDSVMLQHLARRLGPEFGVETPPNALFKYSSIASLSAYLRDQGAAGAPDTPGEDAAGAPQGPDR DAPDTPAAPDQGRAPAVPRPAPSGTAERSTGRGRYAVVGMSGIMPAGENLADFWRLLVENGSAIRPVERW KNRDRQYFAGTIDDHDAFDHSFFGLSAREAMLMDPQHRLFLQSAYNALLDAGYAPGSLREVGVFAGVQFS EYQTALQHSEDRAHPYTVTGNAHAMLANRVSHLLDFTGPSQTVDTACSSGLVALNRGVLSLAAGECDVAL VGAVSVLVDPAATDAASELGVLSPDFRCATFDKDANGYVRAEGVGCVVVKRLDDARRDGDAVLAVIEAVA ENHDGRSNSLTAPNPDAQVALLNRVYTPELAERVSHIEAHGTGTNLGDPIEIGALRTAFGRLAPHREPGS ITLGAVKTNVGHLEPAAGMAGLLKLLLCLRHRRLPANINFKELNPLVELAGSPFRLLLENEPWERGTPLV AGVSSFGFGGSNAHAVLSEAPAPASGPAASRPYWLIALSARSRASLTAMRDGLLEWLDGPEGRHAELGDI AHTLAVGRDHFEYRLAWVVSDTAELRRRLAQARPEEAAKCRSRRLTTHPVRLPAPTDPGHRAALDEVRAR YAEGEEFAWESMFEGERFARLHLPGYAFEKNRFWFE pSLA2-L_p012 KS ACP TE MGMDELLEDDTPVVVGMACRFAGSDGLGEYWERLRLGRSALGTTGRWTEEEDAGSFTGGFLDGHQEFDAR FFRISPNEAQCMDPQQRILLQTVQHAVDDGYLTAADLRDLDCGVFAAGLPGDYRTLVARRADLVYGTHSF LGNAPSTLSGRISYFYDVNGPSLTLDSACSSSLAALHEAALNIRAGQCRAAIVGAVSVFSTPEVLRFAQR SRMSSPEGASLPFTDAADGFVPAEGAAALVVMRHDEARARGLRVYGAVQATGTNHNGTTNGLMAPSSKAQ SRLIAELYDREKIDASQIAYLETHGTGTPLGDPIELEGLRSAFRRAGADGCHLGAVKPLIGHTLVASGLA SVVKALLAFHHATIPPVAAAGEAVSYLDVAPFKVNREPLPWPEDKPLCAISAFGFTGSNGHVVLRRLPDA PPTADAVDRRPGRALPFCLSAESPDSLAALADRCRTLVAELPGDRLWDLSQLLLRRPRLAHESVVVARTR DELGTALEALAHGGSEGPAPRSADTARLDDDLRELVTRWRAQDMPAVQRRLDAPADLARITLPAYPFDGR RHWLTGEAPEPAAPPVPDAPEAATDALARELCARLSALLGYDEDSDQVVPGTRIASLGLDSLSAVQLLSP YQKAGSAIKAHDLFRHETVADLAAAIGGRPLAPPPTPPAREPGTTRRGGAGPDHAPLIRWSAYGDAGRPT LLLPPLNCDERAWAQQIPALLRAGRTVYVPEYPGHNDTPFDEERFSFEALADEVAGFLRDTADGPADLVG WSLGGCVSTLTALRHPERVASLALVSCAPRYGEDAFERTLDLREELRLHGGLLEAVFGEGGNLAEKFGGN ASMDVLRCYYTDLTAFDVVDRLPDITADCLVLRGVGDCVLDAEAVELYSRIPGVRVREFEDHGHYVPLTA ARAVNRTLAAFWAGRG Leinamycin LnmI CY CY A PCP OX (KS1) ACP KS2 KR ACP KS3 MEPGTSPSGQQDASGLAARVTAVMVRVLSAARPDAQPVTAACELRGLGLDSMTAARLWLAVQGECAADVP LGWLTEATTVGEYAQRVADHASQAVPVQGAGAVGAQVAADPDALHEPFPLTPLQEAYLIGKEPELQADAV GCHLYREFDVPALDTERLRAAWQRLVEHHDILRATVTEDGRQQITAQAPRWDLAVHGSATRAEFTETATA VRARMSHHLFPAGHCPPFAIEVTLGPDGTGRVHFGIDAIVTDGQGLDLLTAQWEACYADPSHLLPAPTAP LSVRDCVVALDAARRTEAHRRDLDHWVRRLRELPGAPGLFTADAPERGTGLSCVRRSSRTARLTAAEWRS LRARAEELAVSPTSLVLTVFTEALARHGAHEPFSLVVTTSRRPQLPPEADHLVGPFTGTTFVEAVPPQQH TFEEAARLTHEGLWQALEHSAVCGVSAQRALRGGGPGPLPVVFTSMLDAAGRPRARGFAAAPVYAVSQTS GVWLDHQMWEQDGALHLRWDTADGCFAPGVVEAAFASLCNGLRALAVAGPVVTRPLNDLQQAYFVARAAG EPGPWRGCQVVVPYDTDERVDPVRLESAVVRLVEAYDVLRSAVTQDGVVEVRAGAPRRWTVPVVAGGCPD EVRDAMAAANFPLGRYPQFEVRVVRGDDGDTVLMSMDLTLTDARGIHLTGRELMRLYADPAAEPRPAEAA RDSARDADEQARSRAHWQDRLRALPPGVPLPGPRDADGPDRRVRLAGAPLALRPLTDRCAEHGLSLDAVL LTAFTDVLARTYGTDFAVPVVRWDHGLDPQRPGEFTALSWLPCAPRELSFTARARTYQEGLERDADVSGS GLPELRRAVARSGGAGYPVVYTCALDLTDRPLPGSVRAGQWLSCTPDVFLDCITTVDAGQLQLAWDAVDG RAPQGGWSELHAEYRRSVARLADDAAAWQEPAGGDTSGADDGEVRGAELHKILHEWNDTTRAFPDDRLMH QLFEEQAAQQPRAEALRWRGGGTMTYQELNRRANRIAARLAAEDVGPETVVAVSVPRGPMMVAVVLGILK AGGVYLPMEPHLPAERAAVILEEAHAEVVVTTADREGWPVPDGYARVCADAAVEGPHPADADNCPRPVTQ PHNTAYIIFTSGSTGRPKGVAVAHRPVLNLINWCRRTFGFGPGDMGLCVTSLGFDLSVFDVFGLLGTGAA LYIADAEQQRDPALLLDVLIEEPVTFWNSAPTTLAQVGPLLDTVGTAGTGDLRLVFLSGDFTPLPLPDEV RAVFPRADMISLGGATEATVWSNWFRIGAIDPAWRSIPYGRPIDNSRYHVLDEALRPCPVGVEGDLYIGG ECLALGYVNQPELTADRFIPDPFHEDPQERLYKTGDRALYYPDGNLSFQGRADGQVKVRGFRVELAEIEH RLRAHDGVKDAVVLAREDGCGDRTLVAYLVALPGSAPSGRELRGFAGQTLPEYMVPNFIGFLAGFPATAN GKLDRAALPWPLAKAHLTPPDRSADADPVGSEAEAAVPVKESAAEQPAVAGGAGPSVSVPSRDELCAEIA DLFAQALGVESVDADTDLWDQGATSFTMVRVSGSLQRSYKQRFPVSALLDNPSVSAIAGWVHAQLGGGAD AESTAAAEAETATSVDAETTATTVTQTTAASDERPDSGPGPVDFFATEERERFKRQHWNRRPDEPGLPEV PLGDARFEDELHAWRASRRDFLDQPVPHRSFSRLLGLLRETTGADGTGALYPSAGDTYSVQVYLHLTPDA VEGLDAGLYYYDPSRHSLRLLRSGVLPDRGAHFYYNRPVFDRSRFGIYLFGQRHGIEPLYAEESLRYLTL ESGYMSQLLMLGQAAHGVGLCPIGALNTEQLSQWLGLDEGHVFLQAFLGGAAEHPQRTAGGTVPFFTEPT DSDGNSGSGDSSTVITDAVAPVSAAAEDADAEPPAHTAEPAAVIGMAGRLPGAGDLDAFWDNLVSGRTAI GPAPASRPETAPSGARATGGFLPHIDRFDSLLFHVSPQEAPALDPQARLMLESVWQCLDDAGHTADSLRR

SAGRVGVFIGSMWHDYRQQGADRWNGGDSAEVAATASDIANRVSHFFDFRGPSLAVDTSCSSSFAALHLA VESLRRGECGAAVVGAVNLLAHPYHWGLLDGLELLAADAPPAAYAAEGSGWHPGEGVGVLLLRPADAARR AKDTVHGLIEGTRIGHAGRAPRYGAPHTAALADSLARALADASVIPDEVDYVECAAAGAGIADAAELEAL GSVLARCAGASPVPVGTLKPNIGHLEAASGLSQLIKVLLQIRHGRIAPTLVSGELSPLVDWDGLPVELVD TPRALTPRAADGRATVLVNAVGATGSYGHVVVRAPHAHGTGPAAQDGLAGAGAAPSASGPRTVVLSAASP EGLTAAAGRLRDHLAGAGRALCLDDVAWTLQTGRASLGHRLTLSADGLDGVRAGLTAFLDGRACPGLATA AADPALAGVPAGAQDLARAAGDWLRGHAVDFARLWSAPARRVPLPVQDFTVLAQERHWLAAPAARRPDGA AGSAPAAPESGQSAPPASPQVQDDRADRAQEHVAACFAEVSGIPAEQLHPRVPLEHYGLSSRLVARFNER LRQDVQGVSSTVLFEYPDLAGVAAHLAAHHEGPWSAAPDTQPSPPVPSPDPLPVPRTPAAALGESAAADG PEPIAVIGIAGRYPGAGDLETFWSNLAEGVDSVGPLPAERARDGWPTEQMWGGFLDGVDRFDALFFGIAP RDAQLMDPQERQFLQVVWETLEDAGCTRARIREQLGSDVGVFVGTMYNEYPFFGVERSLAGESADTGSAV AGIANRVSYFLDLHGPSLAVDTMCSSSLTALHLAVESLRRGECAAAVAGGVNLSLHPHKFRQQTRLKMSS SDHRCRSFGAGGDGFVPAEGVGAVLLKPLSAAEADGDRIHAVIRGTAVNHGGKTNGYMVPNPVAQGDLVR AALRRAGADPATIGYVEAHGTGTQLGDPVEINGLNRAFAGASVAPASRAIGSVKANIGHAEAAAGIAGLT KVVLQLRHRHLVPSLHTEELNDAVDWASSPFEVVREGRPWAPLTGADGAPLPRRAGLSAFGAGGANAHVV VEEYVPGTAPEPTEPGVPGVLEPQLIVLSAHDLGRLRALAGRLRDRLGRDDRPAPALADVAHTLQSGREP LRERVALVAYDVAGLCRALDLFASGDTGAWVHGRTPGGALPDGPKAVLDAAADRDAELLRLGRHWTGGGT VDWPGLHPVRRRLVSLPSYPFAEDRHWLPEPRTAAPAAAAATLTEPSGTTLYGRTWRALPPLAAAAAPAP SGRVLCVFSAPGEPVARALAALLGPDRVTLVRAGADAGNGVPGITGIGDEAEAAAFAQGLRADGPDAVGG LIDLTDLGGPAHGDAGSWTARLVLLRRLVRTLRGHGGRVLHVTEGLYGPAGPAPSLAGARMAGFVRMLGA EYGRVTGTVLDLDVSAVGPDAAARQILAEYTGPYGPGDVSVRGGVRHRPELVALPDAGHRSLTPAVDRAY LVTGGTRGIGARVARLLVRRGARRIALTGARPQPPRADWPLLSPGTPEAETASLVAELEAQGARVLVHSG PLSERERTDRFLREVREVLGPIGGVVHCAGRGPVGRPSFIGKELADFDPVLEPKTTGLEVLDELCAGDRP EFFVLFSSLSAVAPGLAAGVLDYAAANAFLDCYADHQVRSGRPWFRSVAWPTWSESGMGADRPDSCAPVG VGPLGDEEGLRVLERILALPAEQARIVPCPPIDGIAADPAALLGSPRDTDATASVGSTTSAGSTPMAGST PMAGSTPAAGSAPVPTTTGATPPRPREEEHTVPNTSVTGPPWLAPLFSELLAIPEDALDPTALLGDLGVE SVLLGEILLRLEELTGLSLDPATLLDHPTLELLGRHLADLGVPSAPPAPAATTAPAVAPVTPVTPTAPVA VAPVTPVAPSGKIAVIGLSCRFPGAEDAAAFARNLLGGTCSVTEVPPSRWDVGELYRPELEPGRSTSKWG GFLDGIEDFDPEWFGMSEDEARCLDPAVRLFLEGSATCLTDAGYGARELAGRDVGVFAGARMSHYGRRVG ERRGLVGMGSDQNFIAARIAHHFDLHGPNLVVDSACSSSLVALQLACRSLLDGESELALAGGVDVLLDEE PYLDFSAAKALSRHGRCATFDEDADGFVPGEGCGVVLLKPLEKALRDGDRIHAVIDAVAVNNDGRTMGLT TPNPAAQAKVVRRALAAAGRRADEVGLIEAHGTGTMIGDPIELRALTEVFREETGRTGFCAIGSVKTNVG HLLSAAGMAGLIKAVLAVRDGRIAPTLFCERPNPRFDFAASPFYPSRTAHDWVPEPGRVRVAGVSAFGLG GTNAHAVVSQLDPVLAAAHRPRPALPAPNFARRRLWLEAAPPSAPGPRPSVPGRPPLGASILGLTFEEPL SEPGYAPLTPTPTGADTAAASQEGRKW LnmJ DH ACP KR KS4 ACP KS5 DH KR MT ACP KS6 DH KR ACP KS7 ACP ACP ? TE MNVPSAPQPGHELVCHLVLEHSDFIMQNHRVHGVSVMPGVTFLDIVFRILRDRGFDTARAELRNVLFHEA IATSEGCDRDIRITVSTSTDGSRWITAESRRREGGESAADYQENFRGELVLHDVPEPGPLDVDRLRTTAR RVADLDEMYARARAEEIRHGSAMRCFGRLYYGDGELLAELGLDGEAAALDEHFHLHPAKMDCATIAAFAQ VPPPDQDPFIPVFIESFRAPRPLTGVAYAHMPRPETYAQSGDIMHNDCALYDADGRFLAGFTKLTCKRIR NPELITRLLDAPDVTRTAAPAPAAVSPSPVVAPASSDGGAGPDAVRAHLRELVGTLLGRAPHAIRTDAGF YDLGLDSGHMLDISRRLEEYVCAPLYPTLLFEFSDIDSLAAHLYAEFGAQVRSAPANPPATPATPGEDAG APPASAARSTARAVAPALGCHRPVWTPLPADPGAFAADGARTVVLVGADAATAAALRDAAAPARVVRAER ASAFQRLAADHYRLDPADPDQLASLTAALATDGISATAYVRCARTRDTDGAGSALPDAYLESWALAVAVT GTRPTGPVPVLFLHPRDPAAPRPHEDALGALARTVAAEAPQLRCRAVGHDATATAGDLAAVIAAESTDLS AESEVRHTGGTRLTVRHETLAVPSGNGAGVLREDGVYLVTGGGGSLAALLVDRLVTRGPVRLVLTGRSAP GPELTQRIEGWRRRGAEVTHVRGDVAHTDDVLAAVTCARETYGRIDGVFHCAGSVDDGMFFRKDPERSAA VLAAKVAGTRNLDEATADDGLAFFALFSSVSASVANPGQADYAYGNAFMEHFAEQRAARADRPGVSVAVG WPLWADGGMRVSEDVLRRSADTSGLHALPADAGLDALFGLLSGAAPRAVVTYGDQERIAELLPAPRPSAA QSGRTGSPDSPDSPDGDDIAIIGVAGRYPEAEDLEAFWRNLAEGRDCVGEVPADRWDHAAYYDPERGKEG RTYGRRGGFLDGVDRFDAASFGISRREAELMDPQERLFLTVGRQAVENAGYRPEELARTRVGVFAGVMWN HYQLCTDGSAEPVAPTALHCSVANRLSYCLDLSGPSMAVDTACSSSLTSLHLAVESIRRGECALAVAGGV NVAAHPQKYLQLAQGRFLSSDGRCRAFGADGDGYVPGEGVGAVLLKPLADALADGDHVHAVIKGSFLNHS GRTSGFTVPSPAAQATLIADALDRSGVAADSVGYIEAHGTGTALGDPIEIEGLRQAFADAGLAPGSCAIG SVKSGIGHLESAAGIAAVTKVLLQMRHRELVPSLHSEQPNPHIDFAATPFAVQRTRAPWVPRPGSTVLRA GVSAFGAGGSNAHVLLESAPPAPATPVAGPQLFVFSAKDERTLREVVRRQLRHLDGPGPVGSSADEATAL LTGEVAALLDVPVDAVDVRENLADLGVDRLALAELGRRVEGRLPAGVPLSGQASVTELAASAALAARPDA LPLADIAHTLRVGRSPLAVRLAVVCGEPEELRRRLAAFLDGDEPGEGVFTGRADDDKEPVRLERAAELFR LGRLSELARAWADGAAVEWDDCRAGDGVRPRRVPLPAHPLDERSYWIGGWRSAQETGESREPVETAHAPT AVPAAPVDQADLPEVREERPGLDPQEVLWAVVDAVRTRLYLERDEVDHRLSFNEMGVDSVGAVEIVEQLG ARFALEMDPVTLFDHPTVPRLAEHVRELHRQSPAPRPQAAPAPAQPAAPEAAALPAPAPAPAPAPAPAPA SKPEPAASPDACDDIAVIGMSGRFPGAEDLDAFWENIAAGRDSFTEVPAQRWDVGPVFDADRLVPDRTYS KWAAMLPEVGRFDAAFFNHSPLEAEVMDPQQRLFLEQSWAALEHAGYAVGADDRTSCGVFVGCAPGDYST

LLTEAGRADTGHAFLGTTSSLLPARIGYFLNLDGPTMAVDTACSSSLVAVHLAADSIRRGECAMALAGGV ALMVTPQLHVRASKVGMLSPRGTCVPFDASADGTVLGEGVGAVVLKRLDRAVADGDHIHGVIKATGVNGD GRTNGITAPSALSQAALIADVHRRAGVGADDIGYVEAHGTGTALGDPIEVRALTEVFRRSTDRSGYCGIG TVKANIGHTTMAAGIAGLLKTLLALRHSELPPAPAFDTPNPKTELDSSPFFVVRDRQEWEPGPGGQRIAT VSSFGFSGTNAHAVLAQAPEPQARPEEPDQERLFAVSARDGAALDRLLLRLADSDLDGVTPADLAFTLGV GRAHLPVRAAVIARNVPELRRRLRLLQSGAQAPGCFRTGQGAAAGDLDEQTRAELAGRARSGSPAERVAA LERLAAAYAAGQDLDWQSLSYGDRPRRVPLPTYPFGGDRHWITLPDTDRTAVPATAPATSRVDLPGQSPQ STPHPLLGAVSGAPGDPDGARFPVPVPAAHWVLDHHRIGDRPVLPGAAGLDLAVAAARRCGLRGTVRLHG VQWLRLIDAEAAGTLRLTLTSDGEGYRFALSTGDDGTVCSRGSLTVRPDAQDAAAPAASSETLDVAEIAA RCPYEVPAERFYDDFRSGGIAYGPSFRVLEKITFGDDEVLGTLRATPDSGGFALHPALLDGAQQTIAALE GGNDATLVPFSVETVEVVDATAVPAFAHVVRAGKHRYTVRLADRSGRVCVRYEGLALRAQHNPVDSMMYR PVWRPAPLPQPGNAPAGGRTVVVHTADSTTLAAALAARTGAGLVALSGAQDAAPDPYAVLEQPLETVYFV ARTGDAEGPAEADRTALDLFRLVKRMLAVGRARDRIALRIVLAGAVPADPEDMTETVRPHAAGVLGLARA IESECPRWSVACVDVGADGGTVGAERAAERIVAEPGTEPLVLLRGEERLERVFEPLRPAAPRGTEPFREG GVYVIVGGAGGIGFALSRLLARIARARLVWIGRSPEGPEHRAKAEEIAALGGQVLYVQADVADEAALRRG LASVHTRFGQVDGAVHAALDLRDRTIALMDEEDFLAGLAPKVAGVTAFARVFGAEPLDFMLVFSSAVSFV EAGGQANYAAASTFEDAYVQWLDRRHDYPVSVVNWGFWGSVGAVADDRMRAAFARLGVGSVEPAEGMAVL RRIIAGRLPQTLAMKADRAALPAMGIRVAGTPEGEGPARTSPPATSAAPGPGTTTPAPSPAQVAVPDPVA AGAEGLSAEAVRSYVAGVFAEVLKYESAALDPEATFETFGVDSLVSLNIVDRFEQDLGDLPQTLLFEYMT IDQVAGYFRQEHGEQLTRVIAPAPTQDQGQGAVAASPAAEVVSGAAVQGGDEEVFARAQEAFAAVEAFSR DLLRRTFPRLDGVPRPGERITADELASRLGVVRRHRRLFDAALSILRSCGAVTGDADTLTFAEPSAAPGA RVEGAEVAALYPEMSGHVTLLERTLGALGEVLAGRRNPMDVLFPKGSVALVEPIYKGQPIADHYNRLLAD EVADAARRVRAQEGRPVRVLEIGAGTGASSRTVLAALAAADAGAHYCYTDISPAFLRHGEREFGPTYPQL AFHTLDISRDPVEQGIEAASYDVILGTHVLHATPDMERTLRNIRTLLRPGGLVLVNEITRFSEFLTLTFG LTTGWWMYEDAQCRLPHSPLLAPVQWRQSAAAAGLRTVRTGGLPGVPADELEQSLVVAERPVEDSGDASP DGAADEQSPESVRSYVTGVFAEVLKYRAEDLDPAVTLENFGVDSLVSLNIVDRLEQDLGDLPQTLLFEYT SIDSIAEYLSAEHGERLARVLGGAPAAAQAQPSAPVPAPVSVDVPAPIPAPIPAPVSVPVDVQEPESEPE PAAAVRTPAGDDPADPLDIAVIGVVGRYPQSPDLEAFWRNLSEGRSCITEIPSERWDWRRNFDPDKSRKH RSYSRWGGFLEDIEMFDAPLFGILPRDAADIDPQERLFLESCWELLETAGYLGTYTHEPQTGVFAGLMYG EYGLLAAATDWPEGRYATGHSAYWSMANRVSYTFDLQGPSLAVDSACSSALSAIQLACESLRRGESRMAI AGGTNLILHPAHFAALCARNMLSAADACRVFDDGADGFVPGEGAGAVLLKPLAQAEADGDTIWGVVKGAF SNAGGKVSGYTVPNPNAQARLVERTLRRSGVHPRTVSYVEAHGTGTALGDPIELGGLTKAFRAAGATGDG YCAVGSVKSNIGHLEGAAGIAAVTKVLLQLKHRALAPTIHLDRLNPKIDFAGSPFGPQRTAEPWDRPVAG VDGAERSWPRRAGISSFGAGGANVHMILEEYTGQDPRDAEDTMGAAGAEEPELFVLSALDRETLARHAGR VADFVAGPEGARVRLADLAHTSRVGRRELPERLAVTAASHAQLAARLREFAATGVAGEGVSTGTARKGGA GSGLGAQELTAALAGRRWADAVEHWTLGGRVDWRTADAGRLVRKVAFPTYPFNRSRHWITSDPHHLAPEL ASGGRPAEEPLSGSEPAAPEPAATRLPSPEPAGPEPVAAERPVAVPLPVPDLVQPVEDNDRDEGGPAADV TAERGATHPALALAAHHRISGARWVPGVSLLEVAREACPGADGSAGAEFPFRLGSVRWLTPVDLDAGTDR VTVGFTDDGTGTAFRITAGGPSGTTVARGTLTEGPCADDAGIDLAAVRDRSTGRPDPCEFYDAFARAGLE YGRPLRTVAELWTGTGECLARLSLSRLMRRVGPAHALHPALLDGALQAVSSLCAADESYLPVGMGEIRAH GALPADSWAYVREVTAEGGTGGRRRFDIRLTDGTGRVLQAVDGLEIAPRAGGGAPETRTRYLAPVWTPAP LPAGEQAPGTVLLCGAETPQRQELAGQLTAAGSTVVCASDGPAFARSDAGPHAAYTLRGTDPAEHTRLIE DLAGRGLLPDAVVHLADEAEADIHRQDVDSGESVLSFVLWSAVAVLGRPERPGLRVVFAHRAGAQGAEPL HIAVGATLRTLGLEHSRFSGVRVELPAGGAGTDEVVAELRAARPGAVEVSYAADGGRSEKNLEPFEPPAA GLCDFAPRAGGTYLITGGAGALGLHFAAYLAGRVPDDATIVLAGRSQPGGDAARRIAELNGDGARVLHRP ADLRDAASVERLVASVSAEFGPLRGVLHSAGVTRDARAVKKTARELDEVLAPKVSGTVHLDAATADQPLD FFVLFSSMSGESGNLGQADYAYANAFLNAFAARRDGMRAAGLRSGRSLSIGWPLWADGGMTVDDATREMF ARTWDMVPLSTHAGLEAFVRGLACELPALCVVESLVRREAAAPATAPRPAAGRQELPAMDVVALRELVEH EARVLASGFLLVDPSEVDVAAELLELGFDSITLTELVNKVNERFGLDLLPTVLFECPDLVSFAEYLTQHH AAELAQHYAPDSPAERTEVRDEPAVSDGTPAPAPASPVVPASPAPSVPTVTAVTTSPAPAPAPAPAARAE IAVIGIAGVFPGSADTDEFWEHLAGGVDLVRPVPKDRTAIRANPATRELRGGFLDSVDTFDARLFGISPN EAALMDPQQRLFLQTAWRVFEDAGYRPADLAGAPCGLFVGVATHDYDDLLKENGVAVQAHTATGIAHSVL ANRVSYLFDLNGPSEAVDTACSSSLVAIHRALRAIQDGECELAVAGGVNVILTPGLLESFTQSGMLSPDG RCKTFDADADGYVRGEGVGAVLLKPLARAEADGDHIYAVVKGTAVNHGGRSNSLTAPNPESQARVVAAAV REAGVEPDTITYIEAHGTGTRLGDPIEIEGLKKAFTTLHEERGEAVPDTGRIAIGAVKTNIGHLETASGI AGVLKVVQSMRHRVLPASLHLRRLSPYLRLDGTPFTVNDRHRPWEPALTPDGRQVLRAGVSSFGFGGSNA HVVLEAYPARTAPAVQDFAPHTVPLSAGDPDDLRGYAARLARHLARTPEADLARVAYTLQTGRTGHRHRF AVRVRDRDELIGALEAFAAGELPDHAATGTARRDAPSVQSDEDPALLRKSWCEGADVPWHTWWPKTPGRV PLPTAPFARTRHWFPTPDAEPTAPAVPARKEATMTARSEAQPTRRGPKIRLAAPRSAGGASATAPTREPV PAPPAPAPAPATTAPQPVRADVPPPALPEAAAASTVVGLLRGELSKILGMPSEEIENDAPFGELGLDSIY RMDLVRTLNEAFGLDLKATELYNYDTIGKLTEFVAPLVGPAGAAPAAEPVMAEAPQQSSASLEDLVQDVI ERELGRTADPAKSFVDNGFGSFDMLRVVASLERVFGALRKTLLFDHPTIGALAAHLAETHGPEAASRLSS PPQDRPRPGPAASQEPYTGGALVVEKKALAGQPELASAVAGLESAYGREGGLPGRDIAPLIFLGAGRTAY FNFSVRDDAMLTWSYVGPTEEMPALATEFVRYGQAHGLAANIVSLIRLEEVDGVRFTATPFGALQRLEGI

KDFSLEGGRMQRLRYAVRKFEKAGTCRTEEYAVGSDPRTDQEITTLIDRWSAAKEMVNPYVSTVRDEIGR GILAARHRMFLTYLDDRMVSAVIVTKIPSEDGYLLDLEFYPEDAPLGSLDHTVVKIIERTAAEGCTVFSF GGSFGAKVCESPNAAPEAEAALTELRSRGIFTGDGNLRFKNKFRTENLPLYLCQPADAERTDVSRLILMI ANPEVGGDRAPTAPTALAAPAPREAPAAPAPRQAPAPGQAPAARPKPAAAPPAAVAAQATEVPADARRRE RQLADHGWNALHLASGDVEFDLITDSWAELDRPFVHARTARLHAGAAGRPVGQTLEGLDLLPFSCVVATT SGRAAEAALCRAWPQQGVVVHNSLFPTWYFNHLDHGFTPVAARRAAGADDGVFRGDLDLGHLNGLLTEHA GRIAFLCVEVSNNAQGGAALSLHNLTGIRETADRHGLQLVLDATRVLDNAALIAAHEPGQTGRDPLDVAR ELLSLADSVTISLSKDFGVDTGGIVATDDPTVAHHLRERIALRGPEAGRATRALAAAALDDLGWAATATG ERVRRVADLRQALAAAGAPVAPGTGTHCVLLDTARLPALRGHEHPVPAFLAWLYLHTGIRAAAHLDDGPG TSSLVRLALPVGLGQRETAELTARLTALFGAPQQIPELLLAASDGPAALASYHPVEQVPDDIREAMAEGH TAENDNWAVLREHHPGVERVLLRLPAGDGGGDVEVFTAGAGPALLMMLPFNIGAGLFGPQFAALSERYRV IVVHHPGVGDTTACEELGYEGIADLCLRALRRLGVQGPVHVAGASFGGITAQTFALRHPESTASLTLIGS SYKLGNRAGEVNRLALVAKEDFDQVQSLSGSSRLDRERARFERLLLRCESMDPQTGLRYLDVFATAPDLL GRLGDIAVPTLIVQGRHDTVIPQKTAHLLHGAIPDARYHEVPDAGHFPSLSSSEEFNAVLSAFLEEHPA Macrolactin MlnB KS1 (AT) KR ACP KS2 DH KR ACP ACP KS3 DH MVHLNKQSADIAIIGVACRFPDADHYHEFWENINSGKDSIREVPIERWDPDLYYSADISIPNKTISKWGGFIHKADHFDH KFFNISPREAKNMDPEQRILLEETWRCIEDSGVSLQDLQRKTTSVFAGIMNSDYRQTGHAESEIDSYACLGSFEAMLSNR LSYTFGLTGKSMSVNAACASSLVALHEAVKSLRTKESDYAIASGVNLNFQPGKYISFSKARMLSPDGKCKTFDAAANGYV PGEGAGVVLLQRLGDAVKAGHHIYGIIKGTAVNHGGKSRSITAPRAEAQCRVISEALHNAAVDAATVSYVEAHGTGTSLG DPIEIEALTKAYRQYTEDTQYCRIGSVKTNIGHTEAAAGMAGLIKVLMMMKHRRVPKSLNVHTVNPIIQFEKTPFRPALD SSDWKAADGAPLRAGISSFGFGGVNSHVIIEEFIHTKDESDRKGRVPFLFSAKSEESMKQMIHHWRTFADDSEEFCKISN EVISSTLLTGRTSFDYRAGLLAGSKEEFKNQLKEGLSFRRKQDSEWALAIGDFKWESYKQFAVLKRVFPDLEKNVRPVLK GIPTLHSSFKRKWTPEKIRLYSLVINTEIIKSILASGFKPSLITGAGDGYYVALAAADIIKIEKAISVITGAEKPSHISC EPPSMPFVNPYTSKTYPPVRLNEEYVRMLLNGLSFPADFADRLYGKTRLLLEHQYTFKGFLEEWDKAGKTQEIEILSYIV NRTADKRNALPADEEAAIMAILASMRRLYKRWDLTDYDGFFNNDYVLEILNLLDEGILSKELFLSMLLKKQDGIKQAVAC INEQPAGFYDKTRFPLMTEYNQMDAVSQEIADHMPLHTEEKGTEPDVNISDFSVFQFGSLPPSAKLNKAAAFEADKPADE ALYHSFLQMWLSGEEIEWAKLGDYHKRKAPLPPYPFERCQFSLNPQPVKPDAAFSEKKNQALYTPVWKETALENEAGSGQ ACTILLFSGNKDYFEELKKREDTSAYLIMPGERLEQISDSVFTINRQRPEDYQGVIRLLKEKGAAPDAILHTWSEKQPEL EETLESGIYSVFYLTKALISENLINKVTFIYTFSADQKEKLPYFEGVNGFLKSVKQEYPQLHCKTVCFEHDSASVSFSER ADILYKEINTAPDRHIHITYRGCVRYARMLVKQRETNRKTIQYPEKDKVYLITGGFGGIGSKVAEYCAKTERSTIILSGR SVLNEDKQKHLEYLNSFKAKVYYIQANISDKEAVKKMIDGITDQHAGLHGVIHCAGVIRDSLLFRKTKHELSEVIAPKVH GALNLDHATRSLELDFFAVFSSVVSIAGNEGQCDYAYANGFLDHFAEYREQKRQNSLRSGRTLTINWPLWQDIGMGANLS GQGRTSLFHGSGLEELPAEDGTQWFSRIVTSGQLHNIAVCGDHERFEQFMRQRFLTDETETGSAIPLAQGDILDQTVLFL TNIISSEIGAEREEIDQDVHLAEYGMDSVMIHQCNTKLEQSLGAISKTLLFEFHTIRDLADHLVKEYPDRLGRLFSREEK GKQIQSITPARPEQNITAPAAEEKEHLDGIAVIGISGRYPGAENIEELWELLSKERTAITEIPKERWNYETYYDPDPAKA HEGKIYCKWGGFLKNAESFDSLFFQISPREAEAMDPQERIFLETVWKAFEDSGYTIEGLRKQTEKHVGVFAGVTTNSYKL LGERIPTDKNDVLPNSFPWSLANRVSYTFDFTGPSVPVDTACSSSLTAIHMACQSLTKGECSVAVAGGVNLYLHPSDYLY RCQMGMLSKSGKCRSFGEGGDGFVPGEGVGAVILKPLKDAIRDNDTVYAVIKGTAINHGGKTNGYTVPNPAAQADLIQGA LKAAGWSARSVSFIEAHGTGTPLGDPIEVRGLTKAFRAYTEDVSYCSLGSIKSNIGHLEAAAGIAGLTKIILQMKYKKIA ATLHAERVHPDLYLEETPFCLQQETADWIKPANEKHSDSKYPRRAGLSSFGAGGANAHILVEEYESAADCHTRREESEEL IVLSAKHSLSLRESAKQLEEYLQKARHKQGEFLQQAGTNKPLHLSDIAYTLLEGREAMPERLAVISNNIDDLMLKLNHFY NGIDDHEIFRGKKPNHKRRQRQSDLPLKSGSTTLTEMAEFWVSGGNLSWEDFRTGRKPRKIALPTYPFLKNRLWVSNKAQ TTAADKAPLFDFSAGECRFYKTLSDSEYYVKDHVVHEKTVLPGAAIIEAAREAGERLYGKSVIKLSQVVWAVPITVEKEK TIMIDLLPNQKDGRFVVKTDMQPEAAVHCQGNIITCGDQDASHTERFQLDSWLTGQKRLISSAECYRDFRQSGLEYGASF QVIKQLFIHENAVLARISLPESIHKKSGTLLEPCLLDGIFQSTTGFTSGQEDDHTAYLPFELGELEILHAPSANGYAYIT AADERQHDDVKRFHILFMDENGSVSLKIKNLALKALRAAPQTQDERHSVKYYTDMWKRAPLLHQPEASGLNSCLVISLRR DISEPLIRQAYKDIGLNMIFVRHGGSFQEKEADSFELNSVKLEAYQKLLAILKERQVTIDRVILIGMSPETGIEHNIREK LEEAVLPVFNVTKALLATIPRHKILISHVFFTRENQILPYQMAISGFFRSLHLEHPMLSGKNIEIHSDEIQLQLNAGLPE LKNLVKETIISDETSEIRYRDGIRQVKHSAEIESAEPPEKMEVKEGGVYLITGGTGGLGLIFARHLVRKGRIKLVLIGRS ELSEEAVSNVKELEKNGSEVFYVRTDISDKENVNNLIKLVKNKLGPVKGIIHSAGVIKDSLLINKREEDLNSVLASKVYG TIWLDRYTDREPLDFFVMFSSISAIIGNAGQTDYAYANRFMDYFAEMRAAENKPGKTVSINWPLWKEGGMQIDIHSEKFL YDRFGMLPLGKREGLAAFDQAMTGCEHQIMVFSGNELKLERMITIDSGKSDPAIADENHEPKELSITESLKSTLTRIITG VLKIEEREFDFELPISEYGFDSIMFTMLGNELNETLGISMMPSDFFGLTDFNELLEFLKSEYSEELHLCGSFSSDESAAK DRRENLIEGIAKMMSSILKIDRKEIEEETSFGEYGFDSITFTRLGNEINQQYGTELLPSVFFECNSLAEMTDYVIEQYGE ILFAETESFSAADEKTLYSTPPPESYEHSPEPENKTWQEERHMNEPVAIVGISGRFPQTDTLEDFWEGIEKGRDMITDIP EDRWDWKEFDGDPIRDVNRTKIKKGGFIKGADNFDPLFFGISPAEAELMDPQQRIFMETVWKTIEDAGYKPSDLAGTKTA VFAGVATTDYAERLNENGVSVQAQTATGLNHCILANRISYQLNLTGPSEPIDTACSSSLVALHRAAEGIQRGDFEMAIAG GVHIMTSPTLFIAFDKAGMLSKDGKCKTFDKSADGYVRSEGAAAVLLKPLSKAQADGDHIYGLIKGSAVNHGGRANSLTA PNPNAQADLLTEAWRKAGVSPATAGYIEAHGTGTSLGDPIEVNSIIKAFKTLYQDWDIPFAKQKCCGIGSVKTNIGHLET AAGIAGVLKVLLAFKYRKLPGLAHFSELNPYIKLENTPFYITETAQKWNPIKDEENNDLPRRAGVSSFGFGGVNAHIVLE EYREPQKEVPENNGNTHIFVLSAKTKDQLLEYIRLMLQYLDRVIAGDMTVNASDMEFTLQNGREAMNERIAVCAASLTEL RDKYVSFLDDSKVQKGVFISENTEEPTAVSEYMIEEALQSGKEELLAQWWANGAEFEWKTIGKKKLNRVPLPTYPFAKES YWFTPKKNKSEVKVNSKSLHPLISENVSTLKKQAFKTVISGTEFFVTDHLVSGDYVLPGAASLEMALVCAEISGESKVYK IKDVMWNRPILYKGKTLHIYTDLEMKQDKLNVTICKEGPDGVQQICTQSETVFGDINSNPEYVDIDKFKRSSEPVISREE CYHRFSRMGLTYHSSFQTLKAVYRGDMELMAELELSAHLANGFSHFTLHPSLIDGGFQAAAFLLRDNEKDGLFVPYSLRE LHIKRALTARCHVSVRETGFYTYNIDFINESGEIAVSMKDFSVRKVTGGELTAGRKNEDQEILFLLEQLKNGELSADQVY QLLEGK. MlnC KR ACP KS4 DH MSPDAGLELIRTYRKEQMEKKAEPESQAPSPTIFFKNDWVRTNNIDMPNQQAPGNMLIFDQDNRLFQHAEMMNGDHNRVI LVTPDSDYRIERNRCTINPSDENHVEMLLSDLAVNGFTPDVVLYLWNGEIREFTEESVNETLCRGINSLFLLSKALMRRN EPVTLLHIYWTSGLNQPFHEAVGGFMKTVNMESSKLKAKTIQIRHEHSDINPPVSEMWDAVISEMQRFQTDECEILIDSH TRYVKGLQHIDNPEHDNGSVTYQKGGIYIITGGAGKLGLLFAEHIAKENQAVIILTGRSFLTADQKERISKLNESGSIVE YQRTDITDRTEAERFIFGVKQRYGSINGIIHAAGILRDSFLVNKSLSDFTDVLKPKVYGTIWLDELTKDEDLDFFVLFSS FSAYGNAGQSDYAYANHFMDSFAVLRSQLSRNGKTLSINWPLLKDGGMSLDSSGINQIKEKYGMTPMRTSSVLEAFLKML

RSSFTSLMPAEGKRDKMMKALSIQRNTAAADQDTLTAEHDEEEEYAAKEKVNDYLIKIISGVLKIQAHKINAKDSFEKFG INSLMIMSLISKLEDTFGDLPKTIFFEYQNIEELSNFFLTSFKEKVLKAAGAAPVTRVPKKRENLSKKQHRQQRVASAPS MVQPGEDIAIIGVSGRYPNSDTLEEFWENIAGGKNCIIEIPEERWDFRSNYSPDRMEKGKINSKWGGFISGVDQFDPLFF HISHKEAELMDPQERIFLETSWHTFEDSGYTKEKLDGMKAGVFVGAMYGQYQLFGAEETARGNPIALSSFFSSIANRVSY FFNLSGPSIALDTMCSSSLTAIHLACESIKRGESEIALAGGVNVSIHPSKYLWLSQGNFVSTEGLCRSFGEGGDGYVPGE GSGAVLLKPLEKAIADQDHIYGVIKGTSVNHGGKTNGFTVPNPNAQAELIAENFKKSGISPRSVSYLEAHGTGTSLGDPI EIAGLTKAFEKFTDDKQFCAIGSVKSNIGHLESAAGIAALTKVLLQFKHQKLAPSIHSEQLNQNIRFEKTPFYVQQKEEE WRKESGASNRRAAISSFGAGGANAHVIVEEYQNHADTQTISGPFAAVLSAKNEDRLKEYARRLLQFTERETKVSAADIAF TLQTCREPMEDRLAVVASDLPELKEKLRTFCTEGTIGEGVYKGNVTKDFDKVFIFHDQKMKDKFLEVMMETKDLNLLAKL WSFGADIQWRELYEEYTPQKVKLPLYPFAEESYWVPRSQSAVFPEILPRQSSLHPLLDSNESTLEQQFFKTTLRDKEIWL KDHIVKNKSILPAAAFLEMACAAGTRSYRKKKVTRLKNVIFARPAMLLQESLTIYTHISVKDGSILFNMSPDEDAAGRTG FVTGELDYDHHYSDDDIENIDRQEIINRSAFVREQDECYEYFRENGFLYGRAFQPIQRLWGGKTEAVAHLLLPKEAAYAL EHYTLHPSLIDGALQSLFGITDGREEASVYVPFSIGEITIRKKVSAECWVYARKTGQKGQSELIYDIQLLNEQGERLAGL KDVTIRKKETFSAEAQTRATADSNGKNERVKELLRQLKAGELTAEEADYALERMQD. MlnD KR ACP KS5 (DH) KR ACP KS6 MKEARHIRKKVLSDIESGIISLEEGVKRIQQLGSHSAGGNGQAIYYQTVWQRTDLSIHVKGGRHEGSLLLFDKNEDVSKE LAALHDTRIILVKPGKEFRKTGDGVFEIDPRSERDYINLLGWLIEEEKSDIREAVHLWSDMPFEKTERAIREQCDSGVYS LFLLQQALFKNNCRKPIKLLYGYFSHLSGEQPLYAAASGFLRTLQLENPLISAKSIEMEQSIAAVHAADIIRNELSDFQP SDVEIRYKDMQRYVKQLKTYEPEKNSGSGDVPLRENGVYIIAGGAGGLGFTFAEYLAFQTKCCLVLTGRSPLSDHIRKQL RRLEDAGSSAVYVQADITNKEEAEYVVKKAKTSYGKVNGVIQGAGIIRDSFLLNKSREEFDQVIRPKVLGTMWLNDAVEK ENPDFFICFSSTSAVLGNVGQSDYAFGNSYMDHFMNMRSVQDSDTISLSLNWPLWKEVGMQVDERTVETMKKAGFYPLEK EEGKEAFAVALSSGFSQFTVFYGDEQIDNHVQQLYERKDNIQADEGTGRNIESFDSEKLKAETSDFIIKVIAAEFRMPAD KIDAEEALEKYGLDSVMIINMTNELEKHFGALSKTLLFEYQTAAELSQYFVEEHRDTLLHKLRLGENGSSTPSQKKKDHE QTADVNGKQKIQMKNQVQQEKYHDNDIAIIGISGRYPMANDLDTLWENLLNGKDCITEIPEDRWDSGLHYQPAAGDEVKN QSKWGGFIDDVYHFDPLFFNISPAEAELIDPQERLFLETVWHTIEDAGYAKKTLERKNVGVFAGVMYGQYQLYSVGHEAA VSSSYASIANRVSYFFNFSGPSIALDTMCSSSLTAVHFACESLIRNECEIAIAGGVNLSIHPHKYELLTQGGFLSSDGRC RSFGSGGDGYVPGEGTGAVLLKPVKKAIADGDQIYSVIKATAINHGAKTNGYTVPNPKAQSEVITRALKKGFIDPKSISY IEAHGTGTALGDPIEITGLTRAFSDAERDKKTCAIGSIKSNIGHLEAAAGIAGITKVILQMKHKTIVPSLTHSAELNENI PFQKTPFYVPDSAEKWESSVPRRAGISSFGAGGANAHVILEEFADEAISPLAAEEPEQLLFVFSAKNADRLAEYAKRAKE HIAARDYSLETLRNTAFTLQTGREEMPHRLAVIASTRDELLKRLTDYILGNATNHIFTSGKDTTEAQRMNKAEIEEAAAN RDLVKIAEYWVGGNGVDWPSLYKDATLRRVSAPGYPFAKELCRIDAQNMGSRRMNVNNDLHPYISCNISDFKAQKFLINV SDTGLYIKTKYQDREMFPFLSQIEMARAAGAMASGNPIIKLTELSFREPMLQSGSNEQIRIVLTPDNQGASYSIEKQSDS SIYSSGRLELEGGAYENGNIHLEPFLSQRADRIPHEAFYQRLAEFGYSCSDSLKAAEHCVSRNGQVLLKIKAKAGPKGCI IKPEVIESVYQAVIYLAGENAGELPENIKECTIFDHETEPVYVYAEQTGESDSAYDVYVLDNAGGILMELSGLVFGEKPN KNVRFYEHKWNQKNPLIEIKDREPKTILVFAKDEVLAGALKNQSNSRVILVTPDQRQIDQDLLTFYVNPEVTSDYIRLFE ELEKKGFSPDVILHTGETFYAGDHLLSGLESIFYLLKALSARSDASLYLHSLLLVHSFKEGVNDPYTGALAGCLKTANML VPSAENVKSIGFSERISIEKMAEFCLNEMVSGMERQAEEVKYINDKRYVKTLKDYVFNHTEHSHQLKQEGIYLITGGLGG LGLIFAKYLASQYQAKLVLTGRSPLTADKRHNIDRLQALGGDAVYYQADAADQKTMGRVIEETKRTWGSIQGVIHSAGHA DDRLFTEMNLADFSDGMTAKIEGTVCLDELTKDEPLDFFIVFSSISSVFGDFGQVNYALGNYFQDQYINWRSEQSRRQER QGKSISINWPLWRKGGMHLNKEAEEAYLSASGFDYLETEEGIAAFETILASDCPQISVVTGDAETTPARKDLPHQKVNTL PVRQEEISYTAPAYTDNVLEELKQMVSELLKINIEQLDTAENFGNLGFDSISLKTLAVRLNKKYKLKLTPAVFFTYSHIK SLSEFLNSELRTVAKGNTDAEKNISEKRKVVHAGKTTGKTVKPPRSFPFEKKTTRQADHHPEKQPVAIIGMSCVFPGAKN ADEFWLNLINEKDLIQEIPPDRWDWKKYAEGKGSSEVHSKWGGFITDADKFDEAFFNINPREAELMDPQHRIYLQETWKA IEDAGYKASKLSGKNIGVFTGIQFNDYRQLLMRHSDGAHAFAGTGNSQALISNRVSHYFNFRGPSESIDTACSSSLVAIH RAVRSIQNGESELAVAGGVSLLLDPVTHMYTDKLGILSRDGRCKTFDKLADGYVRGEGAAVLLLKPLQAAMNDRDNIYGV LRGTGENHGGRSASLTAPNPEAQAELLTSVYKNADIPVDTISYIEAHGTGTELGDPIEIEGLKKAFGSFEPRSGKNHDQY CGIGSVKTNIGHLEPASGMPGLIKVLLSMKYKTLPATLHVKELNPYIQLSGTPFHIVNKTMKWATLKDRKGNEIPRRAGV SSFGFGGANAHVIVEEFEYGQDKAVTGEREQIIVLSAKTKERLMVKAKELTTFLHEELSVQFSQQEVQERDLQEAVREAA AGILRLDTADIDAKTPLSEFGFDPLAYSELISFINQMYGTEISLDIFQELKTLSELCRYISSIRNRSADKPYNSNFREKS GFGLEEIAYTLQTGREPFECRLAITCSNTGDLLEKLNGYIQGSRLQGVYEGNVTDFDSLYAPLFGGPEGHAYVQSLIQQN KPAKLAQLWTIGCEISWEDLYEEELKPVKLSLPLYPFSKNRHWIHLNKDEAQKAEAFSNTELHNSNKDTADGEIMSLLEK AQTGEMNTKETSELIEELLFHE. MlnE KR ACP KS7 KR ACP KS8 MQIEQIVKKVKECSLTPEEGLELIKSLGKTHLYEMVWDRHEFKGSKKFPHTKEPILFFCEDDSMYTVMKRQLEGYEAPFI YVTSGERFEDCRNGRFTMNFTKGEDYDALCGVLRSQNIRPRHIIHFLAAGLFKNTEDAMRKQLNKSLYSLFQMFQAFMAN KLCPKAEILYLYENAEGEVQPIYNAVESFLKTVQAENPNFTCKAAELKSMFDEPFTKQHIADVISFEWNNQCKTDCFTCY EPRHYYKRQLQRVKKEDGEKHSFSVKKNGVYLITGGAGGLGYLFAEYLAKQAEVKLILTGRSPASRETAQKLSALENLGA EALYVPADISKEKETDALIKYIKQTFGELNGILHSAGLVKDAFIIKKTKESIEEVIAPKVFGTVWLDKAAEEEPLDFFVM FSSLSAVLPNAGQSDYAFANGCMDGFTQYRSMKGRPGKTLSINWPLWDAGNMTVGPGELQALRHAGLELLSAQAGLAAFQ DSMSRSASQLAVISGDKDRISELLSTDHKKIETVPENNSNLPQLHEKDLKKQTVRLLTEIVGAETGRPADSILPEDTFDR YGIDSLTILGLNSRLEKYFGRVSKTLFFEYSSVEELSEYFLEHYQHELQKAFLPAAEQRIDHSAPAKREKLSVSRIPSAP SEEDIAIIGIAGRYPMAKDVEQFWENISSGKDCITEIPKERWDFRKYYHTGDNARHDSKWGGFIKDADKFDPLFFSISPR DAELIDPQERLFLETAWHTFEDAGYTKKKLKRHKTGVFVGVTYSHYQLFAAGASDDEERQALLSSYSSIANRVSYFFDLH GPSLAIDTMCSSSLSAVHFACESLKRGESTLAIAGGVNLSLHPDKYTLLSQNHFVSSDGRCRSFGAGGDGYVPGEGVGAV LLKSLSAAKADGDRIYGVIKGTSVNHGGKTNGYTVPNPGEQANVISETLDKAGIDADSISYIEAHGTGTSLGDPIEISGL TKALHSSKSDYRCAIGSVKSNIGHLEAAAGIASITKVLMQMKYKQLAPSLHSGNLNPNIDFEETPFYVQSELTDWETPQN QARRSGISSFGAGGSNAHIIIEEYKNEEKMETVKSNKTQIILLSAKNEERLRLLIDAYINELGPNTSLADAAYTSQTGRN AMEERLAVEVSSIDDLRNKLTMYLRSDHKLNGLYRGKARRDAGQKDALSAARFKSAREMAIHWVNGGDVQWEEMYTAELP KLVSLPAYPFERNRYWVPAAKAAQKQKKTGVPQSLPHAPTDLPFDVYKKSWKKQKAAPSAFTKGQVMILANSESERLAFE LFDSDPLIESAVICADNWDHSDGEAKKTALAVIEENPEIIGMIDLSDLRSDQNGARTGTIGKLTLLQEIIKTRKQLFVLH VTRGLQTFLNDKPSLAGAETAGLYKMLSAEYQKIKSKTIDVDGHVGTAAELRQVITDEAYADGLYSEICYRNGERYIPYV EKLHAAEINRKLSGLPVCRTDQTLVITGGTRGIGAELARHYAGKGVKKLVLMGVTDLPESDKIAGMLKDTDEKSPLYSKL QLLHELDQKGVQVEVYSGPLTEKETLHRFFSEVRLKFGKIGGVIHCAGAANHSNPAFIHKSDQEIREVFEPKVQGMQVLH DIFIDDKLDFFILFSSVASAFPLLGAGTSDYAAANAFMDYFAAYQHAAGRTYYQSINWPSWKDIGMGEVTSPSYQALGLL SHSTETGIAMLDEMMTINGYPCLIPAKTHPEKFKLQQLLQTRIQAAKNNPDAEEKVISGQGDNEAIIRKLMEIFSAELKI PCGNLDQDTSFADYGVDSILLVQLVKKAEDAFQIKIEPSAFLEYPSFSQLGVYLNELFASEGISPQIDSENIEVRKKEQH INQNASEVRDSGSQIQQTSLNQIAIIGMGCEFPDAPDTETFWTNLKKGQNSVREVPASRWDISSYYSDTYEKGKSISKWG GFLQDIESFDPAFFNMNKSEASELDPLIKKCLEVSVQTLRDGGYTKEEVSNKEVGVFIGSRTGTFMSKIGSPSKNTIVGI GQNFIGAHISHFFNLKGPNLVVDTACSSSVVSVHLACQSLMSKESDMAIAGGVDILLDQKPYVMLSEARALSPEGKCHTF DEKADGFVPGEGCGAVLLKRLDDALAEGDRIYAVIDSSAVNNDGQTMGMTTPNPKAQSAVIKKALKKGGIDADTLSYVET

HGTGTMIGDPIELKALTEVFREVTEETQFCGVGSVKTNFGHLMSAAGIASIIKVALSIKNQMLPPTLHCKTPNPRFKFDQ SPFFPNTSLKEWRPRKGVLRAGISSFGFGGTNAHMILSDSHLTLGYGETKRHPLSPVIFNKEQCWIDNGETPEKEESELL IPLLDFKEL. MlnF DH ACP ACP KR KS9 (DH) MRQVASNQNYQFTLTIKHTDYIVRDHRVHGTRIIPGVTFLDMIYRMALSKGLPIEELECQNILYLEPVATSDTFDREIRI RFQGLEQGWEIQAKSRKVKDDRILDESWDENMTCRLMPKIPESMSSINIDEIKHASAREADMEICYDYLKKVDIEHFEFM KSLGKVYASDHSVLAELTLSQIANQYTGYFQLHPTFLDASTIISILYQACPEYFTQGSPASRMKTYIPIHIESFRMTKRL EDRCYVYIEKQDQNHDSGDVIQVSYGLYDAYGEMIAYFTRLSVKHIRSKDLIENLKQTRLETEAASQPKDSLIRKDSIIN RSESIETHLKELISGVSNIDLRDIRTDIGFYEQGLDSASLLAIVKELENKTGEQLYPTLLFEQKTIRELAAYIKENQRMS SYFLTRNQPAEKPDMKESMNENLSALITEGDIQQLIADIKGTAPETLSVVKGFYEQGLDSVTLMQAVKALEEKTGRELYP TLLFEYPTIQKLANYFAESGEKTSVEKDLPLHYGENHTALTYLTPHWRQKAAAWDPNCGNKKKRTCLLFQYDRELFHFMR ENAENGFENTQIILVLSGNRFSYHGDGVYEIDHREEAHFDRLAADLKKRGQMPDTVVYGWPEGSFAGPEKISEQLSKGAY PLFFFSRALMRSKTEKKVVSLFLYPADHKNDQPLYASVHGAGQSIVLENPKLALKTIGISVSDKSSLPELTAEIIRVESA EAHPGETDLYYEGNVRWVRALREAEPAPNSDFSFKENGVYMITGGSGGLGLIFAEHIAAQTKANIILAGRSELTEDKKNK ISRMKAGGSSVQYIRGDFSDSRDAERIIKTIKRQFGEINGVIHSAGVTHDALLIQKSKDEIQEVIAPKINGTVLLDSLLQ TEPLDFFVMFSSSTSMYGNIGQTDYALANRFIDLFAEWREGMRRKKERSGVSVAIGWPLWEDGGMKVDKQTEKWMKQKIG MVPLSKTNGIKAFQDSLSLNASQLIVFEGDKEKLESALQDTFIEDESREIQINETADTRHEDIAIIGLSGKYPMAEDLPE FWENLKSGKDCITEIPPDRWNMDDFFSEDRDMKGKSYSKWGGFISGADQFDPLFFHISPREAELMDPQERLFLETAKHCF EDSGYPRNMLEKMKVGVFVGAMWGQYQLFEGEENGVAFSPASVYSSIANRVSYYFHLKGPSLALDTMCSSSLTSIHYACQ SIHCGESDMALAGGVNLSIHPNKYKFLSMGQFLSSDGRCRSFGKDGSGYVPGEGVGAVLLKPLKKAIEDQDQIYGVIKGS AVNHGGKTSGYSIPNPDAQAEVISEALRKADIDPNTVNYIEAHGTGTSLGDPIEIQGLKDSYQLNHPCAIGSVKSNIGHL ESAAGIAAVTKVLLQMKNKQLVPSLHSDIVNPFIDFDQVPFQVQRKAAEWNIPQNSNAVHPLRAGVSAFGAGGTNAHLIL EAYEPPKAFDHQSGRVIFVLSAQDKQRLIKYAEVMADFLSENESKDNNHKLRLQDIAYTLQTGRDHMEERLAIVADSGRV IAEELSAYTRGEKSSLSYTGNTFESEVHNEMPHVCSDYAEAASKWVNGRKIDWETFEVNRNARRISIPGQPLIKQRYWIA EKGEALVSADVSKPTHPFLGSNTSDFNQFSFTKKISRNHPFALSLSEGNVSFFPYASLAEMAIVNAAAAFGQPVQTLTDL LWTESMNGMTDIRELMITLTPERDFARFDIYANTKNENKVRLARGNAHIVKPESGMFPEALDIAEVKSKMTEHPAEAPFV IESAKNSDGMLSLHSLPDELYAKRENFTISPEALESAIQASAFFVSGETFPELIGMGAADVYQPLAQNFYVYTQKENRQN SRDVTCHMTFTDGNGSILAECRDVRFRYGHEKDTVQTDDELIRLLRQLETNDIDQKAVLKQLMGEE. MlnG KR ACP KS10 KR ACP KS11 MNGKREQLSDILDQIQTGQMSADEGYARVTSIQNQKSRASNHPLLYYKPEWTESFIPNKKSAPLTGLLLIFAENERQIQE LSGLFKDCTLLFVIRGKEFAVLHDDTICMNHVKKDDYLKLFRYIHDHYQLPEKILHLWSDSQADMSKEGIQKQLENGLFS LLYITQALIELKWKKIIKLTHIFQTENKEQLPLHHALGGLVKTVHQEHPNFHYQIINITQSEGAGAALPAIADIYQRECD EKRDIHFEVRYENGRRFTKSYNKAGSFDLTQPLKHHGNYLITGGLGGLGYILAKHLSEQWKANLILTGRSDLTEEQEKKI EYLRSSGSTVEYIRSDVSKQSDAERMFSFAKEQFGTLHGVFHSAGVLRDSFILRKTKEEIDQVTGSKVYGTLWLAEEIKK MKVELLVLFSSTSAVFGSAGQCDYAFANACLDQYAAVMTAKESAGRVVSVNWPLWTSGGMNIDDEGISYMKQELGLDPLD DGDGIQALENSLCQSSEQLIALKGRKEKIEDVLKRAGTISLHSDQQEDADLQNDELRQNIISYLKNIMSEELKLPVSLID EKQYLEKYGIDSVMIMRLTKKLEQSIGRLSKTLFFEYHSISQLAEYFLSHHSERMMKLLKPAGTSELVSYQKKPKRKPVE TKAPVRSEGEGSKEHMAADPLSADIAIIGVSGRYPGAENIREFQNVLMNGRDCVSEIPDDRKEMLEGSCYKWGGFLKNPD RFDPLFFRISPKEAAFLDPQERLFLETVYNTIEDAGYKPSDLTRKKVGVFAGVTYGSYQFFGVEESLKGNELAVGSPFSA IANRISYFFNFKGPSMAVDTMCSSSLNAIHLACESIRRGESTLAVAGGVNLTLHPNKYTLLNQSRFFASDGRCRTFGEGG DGYVPGEGVGSVLLKPAVEAVRDGDHIYALIKATAVNHGGRTNGFTVPNPNGQSELIQDALQKACIDPRTISYIEAHGTG TSLGDPIEITGLTKAFREFTEHTQYCSIGSVKSNIGHLEAAAGIAGLTKVLLQMKLKKLFPSIHAETLNPNIDFKASPFY VQRSLQDWKKPKLQENGKTVTVPRRAGISSFGAGGTNVHIIIEEYEETNVSTEHVENEPHIVLLSAKDNERLLEYAENMR DFIQRSLSPEVKDKQPDMKEKVYEVLKPLVSELLHIHPEEINIADHLSEFGVGPLELSRMADFINEMFHIELTMYELTDC PSIQAVTEYLLKEYAGAIRNLFPNEVMEGSQSESVVLRDLAYTTQSGREAMEARAAITGTSLKEMKDKLFEFCRGDKQVP GVYVHQQSSDAFAEKMKALTEGTAGELFVKTIIENGEAEKLAQLWVWGADIDWKSVHQHLQQPGKRISIPTYPFAKERYW VPSRTEKAEIPQHSFQHHLQKKWRENPFVNPSETKEYGLTVAFVNQDTESIARTICSDIDQENLIVIKHHSSFIKHSDQM FECSLLDENHAYDVIREIFSGGERLVENIFDFSDIGNQSENQNGIPYGKFLFIQEIIKRSKKETPLSILQITNGLQVFKA EKPKLTGAESAAFLKALSAEYGFVHVKTIDIDSMKETHELKQIFKNERQCTGENEVCYRSGVRYVPYFEEERIHTGGPVS FPADKAIVITGGTGGIGRAIAEDLVKRGVKKLVLTGTRPLPLRSEWDHLLKEGRQDEKTVSNIKLFQSFEEKGVNYLYYS GSLTNEEKLRSFFHQVSLEFKDISGVIHCAGLHSGGNPAFIHKRMSEFKTVYGPKVTGLQNLERIFNNRPLDFFILFSSI AAQSPKLSKGMTDYASANAYMDYFAAYHFQKGRTYFTSINWPSWKEVGMGTVTSPLYDELGLDSLSTREGLAILYHALER KSSNIIPIVKKGTVFHADSLLNINKTGKASFPVRRQETPDTFDHSEGLVSELSAVFAEELSIPLEKLNPNTDFQEYGVDS ILLVSIIHRIEAMIQKKIDPTVLLEHNTIHGLAEYIGKTAPPLKKQIEQTDSQSSNQQDMQSVTSRNTEPQTASSAKIAV IGIGCKFPGAADKEEFWDNLRKGKNHIKEVPDSRWNIEENYSPVQQKGKSISKWGGFINGIGSFDPEYFRMEEEKAIQTD PLIRHFLETSVQTVRDAGYEETELSGKKVGVFVGSRMGGYGHKLPKESTSHIVGLSQNFIASHVSHFFNFHGPSMVSDTA CSSSLVSIHLACQSIKNGDSEMALAGGADLLLDEIPYLMLTEGGALSPDGQCFTFDERANGFVPGEGFGAVLLKPLEKAK TDGDRIYGIIEASAINNDGATMGITTPNPKLQEQVIQDAFEKADITPGSVSYVETHGTGTMIGDPIELQALTKVFRRDTN KTQFCGVGSVKTNIGHLLSAAGAASFIKVILSIWHKEIPPTLNCETPNPRFEFEKSPFYPNTELRSWKDGKRRAGISAFG FGGTNAHLLVSGLDDSYHSVRTPLPPAEFVRKEYWPDSNRKKQIKQNKKRLLEIIDETE. MlnH DH ACP ACP KR TE MRFSVLVKHDDYIVSDHVLHQVRTIPGVTYLDLITRFLAEKGISPRSFEIKHVLFREPVATSVHFDKKVTFQFTEQENGW LVETTSRKWVAEKAEGEASVNLQAEIIRKNAINEKTISIEELKKGAVRISDAEAAYRNLRRGGLIHKDFMKLEGTVYEGE NYILGEVSLSGLSKEYTDDFYMHPAFLDGSLSLLGILTSDLPDEGTNAFIPIYIETFRALHKTTGSCFVYINKTSITQPP SKDILYADIEVYRPDGELAFYYERFGVKRVRNEKSIQRLEHSQKAKEVGSATNNKEMIRNNLIQEIAGMIEKPAETVKND ISFYEMGLDSKQLLDLSKKLELMLGSKLYPTLLFDYSTIGELTEFLQEKYGADITDSISNTVQHQGSHKTLTDELSSIIG EATNTPSNKADKHQSFYELGLDSKQLLHISKMLEERLDTQLYPTLLFDYNNIHDLAAYLEEKYDVRNTPAAAFKEKTQTK EPSEKPVLESLYLQKEWIESPLKSGEVPKENTLIFDFDSSLSDEIRKYIGSENVIYAEAAAEYEMVNEKHYKFNPEQSAH YSRLLEDMKKSGAFPASIIHYLSKKAYTEAALDLTHSFYSILYLSKALIHQKVKENINILYVHDKGQYTNPVYAAIGGFF KTLNAEQPNIKCKTVEISSRQTIEKAPLLLNELSAGHHQAVKYDGDQKRRVTAYKDASPQTGQKAAKFAKNGVYLIIGGL SGIGWIISAFLYANHGARVIIAGRSKMTADMEEKLDSIRYDGASISYIQADMSDKQQVIKLAEKIHADYSEINGVIYSAG VLKDSLIMNKTDAEAQAVLQSKVNGVIHLDEALRDMPLDFFVLFSSISSEIGSLGQADYAYANRFLEHFAEWRECMRKAG GRSGKTIAVNWPFWKDGGMSVDPGIQDIMKTEYGLHPLENTAGIKAFEHSLLGQGHQLIVLYGEKEKIQNDFKPLSARSA PPLVRDSAIAADFDASSVVTGEAESPFRILGTASNRHLDDYLHYWSRLKKGALQHNQSDAAKKLIAFYQTEETETVHFLA NTENARHMEILMSGKGETILLICGFATTAYMWKEQMKEWADQFNVIVIHTPGYGLSEGSADFTLSGLAQTFIEVLNEIGV AWPIHIAAASWGGMIGQRIAYEYPEKVKTLILSGSYTAYEEDPESSVEEKLKNDFIAIGKSHEYESLYSNQFLNASIERF MKIHQQEGYSTIGFLKDIHTRTLILTGEKESVVDQKETKRLQKLLSNAELKKIKGAGHLPNITHPEEFNKAVSEFIKKSV

SKG Mupirocin MmpA (KS1) ACP KS2 KR ACP KS3 ACP MNIERKKARLAAAINASLKAQPAPSFPEPVAIIGLSANVAQSASVRQFWQALDDDRSLIEEIPATRFDFT SWYAGSNIEEGKMRTRWGGFIPAIDQFDPVFFGMLPAEARKMDPQQRLLLMSVRQTFEDAGYRHTDWKGS ATGVFIAAERNEYHLNLLQAQIDPGEGLDQAASMLANRVSHFYDLRGPSERIDAMCAGGAVALHHAVTAL RSGQINAAIVGACNLLLRPDVFVTLSQSGQMSPEPTVRSFGAGADGYLRGEGVCSLLLKPLSKAEADGDH IYGLIRNTAVNYNGGDAASIAAPSVSAHSSLVQDCYRRAGIDPRHVSYIEAQGMGNPVADIAEWDALNHG LLALGREQGVQLQEGQCAISTLKPMSGHMHAASAIGALFKIIRSLQTEKIHKILDFEQPNLHLHTAGQPC RLATHTVDWPRQATPRLAGLHSYGAGGNNAHILVEEYVHQAPGRVVPSQAPLLFPLSAPTPALLALLAAQ MHQALIDEPTLCLESVSDTLKFGREKFAAAVVIVAMERPGLLDVLAQLHTGDLTGAVVFAKDVAAPTDAA LDPWAELWLAGERPMAKATRAPRVPLPTTPFDTQSFWYDAPAPMAAYPAPGTSRTGRRAWSPDAAEQAVR EALAQALEQPAASLDLDAQFSELGFDSMMVRQLCRHMRDQDIVVEPAVLFEHATPARLVAWLACAPAQRI AAPYHLPSPGARGQIAIIGMAGVYPKSADLSAFWDCLANAGDCIETVPEQRWSLDEHFNADRQRAIQEGK SYGKWGGFIEGLDDFDPMFFNFSLAEATYMHPKERQFIQCAWHALEDAGYTPASLEQEKVGVFVGVSKAG HDNYKDSFFSIANRVSYRFGFTGPSLPVDTACSSSLTAVHEACLHLQAGECTVAVVGGVNAYTHPSTFAE FARLGVLSADGKSRAFGAGANGFVPGEGVGALLLKPLERALADGDMVHGVIAASAVNHGGKANGYTVPNP EAQRAMIRLALDRAGVSADQVTYVEAHGTGTALGDPIEFRGLVEAFRQDTERTGFCRLGSVKSNIGHLEA AAGIAGLSKVLLQMRHGQIAPSLHSQQMNPDIDASLSPFRVPQALEPWDVDGEGAQERIACLSSFGAGGA NAHVILRQAPVRAEPAEDVRADYLIVLSARHEAALVRQVDTLLVFLERNPSLPLRDIAYTLQVGRQAMNA RLSCIATSTADLMDALRRYCAGEAHPGVQSTTLKDADRLSLFGQDESALTLLDQWYAESKWAQLAQLWRA GEVIDWARLVAPGTARRISLPGYSFDREPIPRAPQLVPLGSVARPPAQPGRAPVPPTTAATLLVRPRWQP VQASPAAAAPRRCHVILCEWPGERSDHPGWQVLTPKGLPTERYVHCVGQIAEHLRQIIVDAAHEVISVQV VIPVNRSAWLKWHSWAVRSAQLESSKLRTQLVEIDQSFTFTQVRHAVEQAAALEVHPWLRFDAQGGHARQ WTQATVLDDTHRCGWKNAGVYLLTGGMGGLAQCFAADIFSRVEGATVVLVGRSPLGQAGQDRLDALRRMG GQVSYEQVDISDEAATERLVADVQAQYGALNGVLHCAGTLHDEFLRNFKHQHGDGVLAAKVGGTWSIDQA TRHCDLDCFVLFSSAAAAVGHPGQAFYAAANGFMDGFAEQRTQQVQMGERRGRTVSIAWGLWRDGGMQLD AQASALLERESGMIPLSREHGVAAFHQVMDSDACRIVVIEGDEQRLRRRLHPLSNEATLPADTRMLDVVK RLAGQVLGIATSELEGDHDFDSYGLDQARFNQLIQALDRECGLEVSPLVYRQVRCLDDLVAHLPAQLHAG TAPRAVAGTASAQVLLEHALQVLKRVLSPVVQWPEDRLDSDEPLERYGLDSMMVMTITAALQAQFGPLPT TLFFEYSTLRALAAYLCREHASTLVALVADVAGTLASGPDEARVAGIASHDPVPAGRRANRLHPPRETSQ RFDVAIIGLAGRYPQARTLEEFWQVLSQGRDCISEIPTERWDHSRYYSADEDAPGKTYARWGGFIDGVAE FDPAFFGISPREAMAMEPQERLFLQTAHEAIEDAGYTRQGLAASARHEDAEGMVGVFVGVTYEEYQLYGA QQTAEGRPLVLSMSPSSIANRVSFVNGFHGPSMAIDAMCASSLTTIHLACQSLHSGECQVALAGGVNVSI HPAKFLMLGAGKFASRRGRCESFGASGSGYVPSEGVGAVLLKPLHQAQADGDRIYGVIRGSAINHGGRTN GYAVPNPAAQAAVISRALRQANVQPRQIGYVEAHGTGTVLGDPIEVAGLSRAWRAYTPDRQFCALGSVKS NIGHCESAAGIAGLTKVLLQMKHGLLVSSLHAETLNPNIDFSETPFRVQRTLAPWERPLGSDGVPGLRMA AISSFGAGGANAHLIVSEAPLAQAAHAAMTVTAPLPIVLSARSREALLEVAQRLVDWWLDAAANREPDLQ ALAYTLQVGREAWEWRVALLVTSGDELVRELRAFIDGALEGPSWWSGCLPEAHSLATRPSEQACAAIRQM FDQADLGGILRRWVQGEAVDWSPLYHSHRPARLGLPTYPFARQRYWAPSEVAVSVESVASVAQGGKIRLR ALDTLPVADSAPIVPPAPRILSQPAPLAAKAAPVVPVADDECAQFLRQSLAAMLYCEPGQIRDGSRFLEL GLDSVIAAQWIREINKHYQLKIPADGIYTYPVFKAFTQWVGTQLQPTQATAAPVQREPVATAPQPGAQAS AQRESIQDYLKQSLGELLFLDPGQLRSGAQFLDLGMDSVTGTQWMRGVSRHFSIQLAADAIYTWPTLKSL ADEVDRRVQVVHSSDDLLDTILNQVQSGALAADSACAVVEDVLAQR MupE KS4 DH KR ACP ACP ACP TE MVKDFDSNENAGNASGSDTHPHAFDIAIIGLAGRYPQAENIEELWENLKLGRDCITTVPSQRWDHDAIYD PSKGVSGKTYSKWGGFLRGVDEFDPRFFNISPREAEIMDPQERLFLQCAYHVLEDAGYTRQSLSAKGRVG VYVGVQYTEYTAFSTAQTLVAALPASIANRVSFFCDFRGPSLTLDSMCSSSLTTIHLACQSLRSGESEYA IAGGVNVSIHPNKYLLHAQGRFASSVGCCKTFGQGGDGYVPAEGVGAVLLKPLPQAIADGDRIHAVIKGS SINHGGRATGFTVPKSSAQAVAVRSALHQAGLASSDLSYIEAHGTGTALGDLIEIEGLRTVFEADGFEPQ TCAIGSIKSNIGHCESAAGIAGLTKVLLQLKHRQLVPSLHSTQLNRNIDFAGSPFHVQQTLEPWLPKGAA DAVQPRRAGISSFGAGGSNAHLVVEEYSLQAQAHTHVPTLPSDVLIVLSARTHERLQAVAALLLGRLEQT PLACDLAGLHDLAYTLQVGREALDARAAFTAQSVQVLKERLVALADGAQHPDVLIGQALKPVRLRAGETA VPVQSPAMDDNQAVMRHWVSGGQVEWAQLYQGFQPARISLPLYPFVRERCWVPPAPQTAVLGRFAAPGDG PHPLLSRQITAGDSQQFEVQFCGDEFFLDHHRVNGRKVLPGVVYLEMALAALSRVSGQADLALNSILWVR PFECFNDPVTLTLAVEQARKGSGWEFEFFAWLTREPGGEPVRQVYCRGQASVPAEPAPLAHLDVNALAAL AQGAASTTEFYRHFAAVGIEYGPGHQGLHALRGGAEQVLGHVRLPDFLKPGDEFRLHPCLLDSALQAAMG FTTGSESSQGPQVPFSLEQLTLGRSRRTPAWVRLTAHTSGGGRGSFAFDVEVFDAQGEPCVHLHGLRSRV MARAPAPPSLALMTPGLEAFVEPAWAGLSHAHRIYLCPGSEAYAAQVAEHFPQAQCVLLESGDDQGLTLP ERYCRAAQALSEHLRQLPHDGQGCLAQLVVADDDSSGLFAGLFGLLRSFAREQTSLRVQLLHLQPGDALP PLLQSACTADAELALHRRDGQLFSASWQRRPDEQLPAEPGAAPWKPTGVYLLTGASGALARSIALDIARA AEGVSLVLVGRGVPDDDMAAHIEQLESLGAQVLHRTADLADATALRALVQEVSARVGSLTGVLHIAGCRQ

DGLLRNKSAEHLRQVLLPKVDGLWNLDCATQDQPLEFFLAFASIAGALGNAGQSDYACANAFMDQFAEYR NRQVADGTRQGHTIAIDWPLWEDGGMQLSPEHMGAMTKATGLRPLATTQGLQVLRHIIHQGGARWLVLPG QGATFEALVAGLGVGVAAAVAPRSQVDPSDTLRGLVGQILKVDAQEIDDTTAFSDMGFDSVMLTELATAI NRTYTLELGTAALFEHPTLQALAAHLQGARTAESQPPAPGLTRAQVAQGVREVVAEALKVRLEDIGDDDP WSDYGMDSVSSVQMTGLLNERFDIQLAADTFQAFGNVVELTTAIADIQVVMACADIERQPSAGGGVIADT ALLDELVALVCQLLKTVAGDIDPHTDLHDFGFDSVLLTQLLAQISSTYGVELDPGSVLEDATVAGLVAQV QAQRHGAEPASLRVPQVQERPAPQRVVTLAEPEQRADRQSPVVVLLSAGSAAQLRQVADNLLHLIDGQAD HDVDLHTLARVTQAGSGLMPVRLGLSVVSLEALAEQLRAYLQTDEHSAYAQVGNAEVDASVLNRVMALPG LVDQVQGWLDQGGTLPLLQLWSQGLDVDWRSLAGADSPASALSRMPASPLRESAPVVTLLNHAGEQGLFC FPAAGAGAQSFHALAAALGDVAQLQVLEYPPLDTQAPPDLSMQRMVAAHVHTVTRRCPAGVVRLLGHSFG ASVAFEVAVELQARGRQVQLFMLDSFFYVPQELQGEVLTSAQLRYFLGDTPLCARLLDAQDKGAVVSLKQ VRELMRDASLNQGPAQGPGAWLAAQIAMSVDYRPTHTFTGDTCVIIAAQSILGASSLPHTLARYCAYLTA SPHVATVDGGHMSMLNPGNVHTLARALRLHLDTPGGKSQGRRAGEF MmpD KS5 DH KR MT ACP KS6 DH KR ACP KS7 DH KR MT ACP KS8 KR ACP MKNRLSSLIRRLAGHTHTEGGVGDAAEAGKHRHPGDIAIIGMACRVPGAGDYQQFWENLANARDSVTEIP ASRWDWRAFWGDPTSEDDRSHARHAGCIDAVDAFDARFFGIAPASARIMDPQQRIMLELSWACLEDAGVV PSALAGSRTGVFVAAFNYDYKQLLESAGLPIDAHHSTGNAAAVIANRISHFYDLHGPSVLVDTACSGSLS AIHHAVQSLRLGETELALAGGVNLLLTPTRHIAFAKTGMLSPTGACKSFDEAADGYVRSEGAGLLLLKPL AKALADGDPIHGVIKGSAVNHCGKTHTLTYPSSAAQAQVIEQALGDAHIPASSVSYIEAHGTGTPKGDPI EIQGLRQAFCPQASEPQTCGVGSAKSNIGHLEAAAGVAGVIKVLLSFKAGQLAPLCHFSALSSRIDLQGS PFYPVTRLQPWEPASGVRRAGVSSFGFGGTNGHLILEQPPACAEVDVAARPGWLIALSAKTPASLRRQCS ALHDWLQGAGASASLAQLSQALLTGREHLACRQAWVVSDRDTLIAQLLAASQAEVQAPEMDEEGAAVRQL DAARLIKALPTLAHEPSAYLAHLQTLAEHYCCAVPVKFSVLFSDQTRHHLGLPSYPFARDRFWLPTAPTD LLEYRLQRHDPSIGDHVIADQHRVAGAVTLAVAARAWGALPAGGWCASQVAWLQALDVPLQGALLRVSLR PASAGATDFEVRLEGLVHPLCSGTLAPGQTDEVRRDVHALRRAHPDAWLTREVLYEQLRNVGMAYGSTYR VLQDSHLQGDQSLLALVVVPAGAADDLPFSPAAVDAAFQAVLLAIRQSGEQARLGFSVGQLQLSAPLPER YWVHVSAATTGAQQCRFNIEWIAEDGRVCATAKDFVLKAAPVQQEQSPKAKVHSVEWRVLHPVEEGHAEA QRRTLIISADPAQAQAWSAGSTQASVLAGQSDWSAEQWRDALGNAGAFERLIWLAPIPSGEAWSAQAATA AQEHGVMALFALCQGLLMLKVREHPLELLVVTRQALQVLPGERHDPTHAPVHGLAGTLANECPTWQVRVV DLPLAPMAASPSLVPLAALPVGASGAWREGQWYCQVLREVNYCAAPPVYRKGGCYIIIGGAGGIGVAWTR RLIVDYQAQVYWIGRRPLDENIRADIERLASEGPAPIYLPADAGDPQALREALDWVHGQHAQVHGVIHAA MVMRGKSVQRMSRDEFSQVLAAKVATGAALEQALQRPPLDFLVFFSSINAFERSPNQSNYAAGCCFIDEL GGYLAQHLPCAVAVIDWGYWADAGALAGSPALQVLREKTGAGLIGLSAAMEVVDLALSRPWLRVAGTGRE ARTQLALECPRQLISVMPCETQRMANMLALFATAVEGRGSLQLRGGLMLEPLQTLLCQVLLVQLQAAGLF DQPTPQTTQALYQRLQERSSGAVGVDPRWLAHSLRWLADEGWLATDGDTWRVQRVVAAESAWAAWDSALR EAEGDADRRAQAQLVDACLRALPAVLSGHLRATEVMFPEGSMARVEGIYKHNAVSDYFNEVITQAVLARV RAGHQAGAAPVRILEIGAGTGGTSARVLQGLDSLGVEVGQYAYTDLSRAFLMHAQTAYGEGRSYLDYRIL DVEKDLVQQGLELGSYDVVIATNVLHATADIRQVVEHAKAALKTDGWLLLNELSQASLFSHLTFGLLEGW WRYRDEALRLPGTPGLSSERWQQVLEEAGYRGVMFPCQAFHGLGQQVVMARSDGVVRHAREPQATPAPAP SAESHAPVSAPARRAEDGRPLLLASVRELVASSLQFELCDIRDDEPFADYGVDSITGVALVRQLNARLAI DLHTTCLFDYPSINRLVDYMLGQYPQFATPATEPTDALPVTPPTGEPAQPAVDDQAIAIVGISGRFPQSR DLDAFWEHLAAGADLVSTVQRWDPRHCYAGADQGCDRGGFIERIDEFDPLFFNISPLEATYMDPQQRLFL QEAWNALADAGCLGEQRRAEVSVYVGCEQGDYDQLFDDMPPPQSFWGNAPSIVPARIAYYLDLQGPAITV DTACSSALVAIHMACQSLLAGDTKVALAGGVFIQSTPAFYQKANRASMLSLTGACHTFDSRADGFVPGEG AGAVVLKRLADALADRDHIHGLIRGSGINQDGASNGITAPSALSQQRLHESVYARYGIDPATVQLVEAHG TGTRLGDPIEFQALKGAFSRYTQRKGYCAIGSVKSNMGHAATAAAMAGLFKVLLAMRHRQLPPSLHFQHT NPAIDFADSPFFLNQHLGDWPAIDGAPRRAAISSFGFSGTNAHMVLEQPPLRVHQASLVPAVLIVLDART REQLHQRMADLLALCERDASFAVVDMSYSLLTGRQRFEQRFHVVVADRAELIAALRRGMPADTADLAEAH QRRLQGLSARATGQSLYYLQQLAVFADAWAAGQAVDFAPLFDALDCQRMPLPGYPFARERYWVVEAMPAQ DKATHPLSAAMMPNDGAAMVLRLEGDEYFLDQHRINGEPVVPGVAFLEVLALARAAHTPLTPLSLINLVW QAPLRVVSEPVEVRVTLDVQSRHTGLGGVEVHSGHPAQVHCAGHYAAPATAPAALDLAALREACRTAPHS AHDCYRHFTGLGVDYGVNFRCLVEYAASADIDHPQQLLVRLARNPGATPNTGWLLEPGLTDSALQAAAHW LARDWPEPRALVPFSLERLDVFSAAEPVWAYAVRRQAAGWASVPAVDIQLADANGTICAQLQGLSFRALP PPQHPGGTSLDAGESTLWTGDWQPREATMALPDSVGERLLMVAAAPQRLLMEQALHGLPWHSLVESEWPV GEGYTQAAISLITHLQAHLRKADGRPLHVQLLVEPHGPWALFEGLAAILETAALENPALTVQCLLVEIQA PSASLVNVVNQALALGDPRLRWCDGQWQSFVWRQLPSGPGVVPWKATGVYLITGGAGGMGQVLAEEIFRH APGATLVLATHRPTTLEGLAHLHPAFNRLRERGARVEVVTLEVSDRLATQALVERILERYGRLDGVVHNA GVTRDAYLLQKTAEDVREVFAPKVQGVLNLDAATAEVVLDFFLVSSSISAQLGNVGQADYAAANCFMDGV VRARQRQAEQGLRHGLSMAVDWGYWADGGMRIDALSLGLLKQAWGLLPMPRDVGLHALYQAFKHRQANTL VHYGVASSVRRLLTPTTHRVEPLEQWLLANVAALTGVPVADIDLQQPFADYGFDLPMRQALVQRLSETRD LAGQGARLLRCECLQALLDHIVQPPLTDLTEKTPAMDTRDDSQTRHARDFIIGLLRTVLVTVTRVSPAQL QDDRHFEHYGIDSLMVIQMTAELEKSFGSLSKTLFFEHSSIKELADYFTRRHAERLGELAGSGPVAPAPT VAESTPVAPVNALPDASLAQPIAIVGLSGRYPKAEDLQAFWRNLAEGVDCVTEVPAERWSLGDLAQPGRL

PGGKTLSRWGGFLDDVDKFDPLFFNISPHDAEYMDPQERVFLECAYATFEDAGMALGLRSPSALRRTGVY VGVMYQEYQLFGAEQTLLGRPMALSGSSASIANRVSWSLGLSGPSLAVDSMCSASLTAIHLACQGIRSGD CDVALAGGVNVSVHPNKYLGLAQGNFASSQGRCQSFGEGGDGYVPAEGVGAVLLKSLSQAVADGDRIYGV IRGSQINHGGKANGFTVPNPNAQADVITQALAAAGVDAADVGYVEAHGTGTALGDPIELAGLAKAYRHYT DQTAFCALGSVKSNLGHCESAAGIAGLTKVLLQMQKGQLVPSLHSEVLNPAIDFAQSPFVVQRHLAPWPR RVRRVEGVTEECPRLAGLSSFGAGGSNAHLIIEEYLAPTQPESQSRQPLPVAVLLSGANAERLQASARRL LAFCASPEAHDLSLHDLAYTLQTGREALNARLGFLAHSIDDVQACLREYLQGALTSGRVQVGSARQDENP LVRLLGEDDLSAMVAQWAATGQQDKLLALWVSGGDIDWQALLPGRWGRIISLPGYPFARERFWYTGINSD IGQQHPRSPGVQAAPLSVLNCSDLTGLGFTCQVSGRDSFLADHHVQGKAMMAGSAFLELARKAAVAVATP DQQGALVRLSDVVWLAPLVLEDGDAQLRVRLFPDDTARVRFEIATSGAQAQALNVRGVIEQVPMPTRPQV DLPALLARLRSSADFHERNPGQLYDAYAGLGIDYGATHRCLSAVYVGDGHALALIEWPAAQPFEASYGLH PSMLDAALQATRVLSDESALLQVPFALDQLQVFAACEPRMWVQVNRDPQRESYDLELFDELGWLCASLRG LKVRQWAPPGNGGLVEGDEEVGLPAGEVLLVPQWSPLAMQAVTASPTATLVIGADASQLRSLEGAQGPLL SCASVPSDSVEQWVTRFQGLPAFDRLVLVIPPSAARHAGDECLIDEQHACALEQLRIVQALLRCGFDKRA LHYVVVTRDAWTPHDAQPVHAAVHGLAGSLAKEMPHWTVQAVDLAHQERLAPTHLAVMPVDPAHTSRRLR DGVWEGRQLLLHRPQASAQPAYRSNGVYVVIGGSGGIGQVWTESVAREHAAQVVWLGRRALDASIQAALD QVALHGPRPFYMSVDATDAGQLQQACEQILSRFGRIDGLVHSAIVLDDRSLANMSEDQLRRSLQAKVDIS VRMAQVFGGQALDFVLFFSSLIAFTRNAGQANYAMGCVFKDALARRWGSSGSVPVKTLNWGYWGSIGVVS SAAYRQRMEREGIGSIEPREAMQAVRTLLASPLDQMAFIKTLRPITLDGNAEADQWVSQAMVANGPLHIE ADVAQWVAADGAHAAALQDKYRRDAQRERLPQCQVLLVQLQAAGLFDQPTPQTTQALYQRLQERSSGTVG VDPRWLAHSLRWLADEGWLATDGDTWRVQRVVAAESAWAAWDSALREAEGDADRRAQAQLVDACLRALPA VLSGHLRATEVMFPEGSMARVEGIYKHNAVSDYFNEVITQAVLARVRAGHQAGAAPVRILEIGAGTGGTS ARVLQGLDSLGVEVGQYAYTDLSRAFLMHAQTAYGEGRSYLDYRILDVEKDLVQQGLELGSYDVVIATNV LHATADIRQVVEHAKAALKTDGWLLLNELSQASLFSHLTFGLLEGWWRYRDEALRLPGTPGLSSERWQQV LEEAGYRGVMFPCQAFHGLGQQVVMARSNGVVQVPRRVSQPAAPKVALAAQPAAAPQHGVAAPVPAAAAD QFTQVRQEVMASVAKALKVALEVIDPQESFSDYGLDSITGVNLVRVLNERLGIDLGTTALFDFSTATRLA RHIVEQHGAHLPQPAVTRAAAAPVAPLAVAVPTASSPAAAPAPRVQSPESFVREPIAIIGMSGRFPGAES LEQLWEHLAQGRDLTTPVERWDLRGSQADVSGKGLCQRGGLLSRIDEFDASFFNISGLEATCMDPQQRLF LEQAWTALEDAGYVGQATEGQPVGVYVGASASDYRSLFAEAAPAQAFWGNASSIIPARIAYHLDLQGPAI AVDTACSSSLVAIHLACQALWTEEIGMALAGGVFVQSTAGFYQAAQTAGMLSPSGHCHAFDARADGFVPA EGVGVLILKRLRQAQADGDYIHGVISGIGSNQDGASNGITAPSAQSQERLIRQVHRDFAIEPGTISMVEA HGTGTPLGDPIEFESLTRAFARPGQQAGYCALGSIKSNLGHCVTAAGVAGVLKVALALRHGQLPPAAGFT QANAAIAVQGSPFYVPDQLRPWATLDGVPRRASVSSFGFSGTNAHLVMEQAPLPQQRGASGAGPWLVVLS ARSAQQLREQASNLAAHCVAVQRLDMAAMAYTLMAGRKHHEWRLAMVTHDAGQLQQSLEGWLQGRDEATV HSGHWDVRRFVEQQEVLQAARECLIRLMGNRDQSTRGEALTSLAQAFVQGYELDYSSLFMADERRRVPLP TYPFLRQSYWVSAPEVEEPTAVPAEEVAGQWLFCAEQWRAHDLPSNFDWAASIKARSGARVAVVTREQAR FDAFSQLLCTLWAQAGSPPPSVQRLLPDALPARGALPEVIFFIGENSSDGRASPPGGLDAIKQVLEVSRH LMATDWEHAVECFHVYRASGSGSDCDAQAISGFAASASLENARHGWTLLECDAVAGPASDLQLIVREWLA ADRQGSAPAVVKYQGTQRLRRLLVQREAAEAQAPRFRRDGHYLVVGGLGPVGELLCQELAGTFQARLSIV SRSAPNAEQQARCDVLRALGATVDYSSVDITDLPALQQVVERRVQAAGPLQGVIHLARLVDDGLIVAKQW EAFERSIGAKVKGTINLDLATADQPLAFFTVFSSMAAYGIRGSADYGYAAAFQNAFVRYRQTLERQGKRH GVSSACTWGAWCVDRYMPANRPAHLQALGLGLIDMQSAFEYLHTGAEPGVVGAMKVLDPALACRGLGIEP LPASSVPPAGDAIGLHAQLHAWEQACEAGATPDAAQWCKVLSRFELDALDEATIDRLDRLFFPSAPRPAT VGAGALLEQVREVIERVLVVDEPDLDTAFSRYGMDSVGAMQVSSALSRALGWLVEPRWLVQHATIRALAE FLQSRNEAATQ Myxovirescin (TA) Ta-1 C A PCP KS1 KR ACP KS2 (ECH) KR ACP (KS3) ACP KS4 DH KR ACP KS5 ACP KS6 DH KR ACP KS7 ACP MTTREVLAAFAEGRLSKVEARRRLAALRAASIRLPLSEGQKGLWAMQRARPESPAYNVPLAYRLRGKVDP ARLTRAWEGLLERYPLLAGAIRVEGTEPVIVPSGQVSAEVHEVPSVSDSALVATLRASAKVPFDLACGPL ARLHLYSRSEHEHVLLLCFHHLVLDGASVAPLLDALRERYAGTEAKAGLLEVPIVAPYRAAVEWEQLAIG GDEGRRHLDYWRHVLATPVPPPLNLPTDRPRSATGLDAEGATHSQRVPTEQALRLREFARAQQVSLPTVL LGLYYALLHRHTRQDDVVVGIPTMGRPRAELATAIGYFVNVMAVRARGLGQHSFGSLLRHLHDSVIDGLE HAHYPFPRVVKDLRLSNGPEEAPGFQTMFTFQSLQLTSAPPRPEPRSGGLPELEPLDCVHQEGAYPLELE VVEGAKGLTLHFKYDARLYEADTVERMARQLLRAADQVADGVESPLSALSWLDDEERRTLLRDWNATATP FLEDLGVHELFQRQARETPDAMAVSYEGHSLSYQALDTRSREIAAHLKSLGVKPGALVGIYLDRSAELVA AMLGVLSAGAAYVPLDPVHPEDRLRYMLEDSGVVVVLARQASRDKVAAIAGASCKVCVLEDVKAGATSAP AGTSPNGLAYVIYTSGSTGRPKGVMIPHRGVVNFLLCMRRTLGLKRTDSLLAVTTYCFDIAALELLLPLC AGAQVIIASAETVRDAQALKRALRTHRPTLMQATPATWTLLFQSGWENAERVRILCGGEALPESLKAHFV RTASDVWNMFGPTETTIWSTMAKVSASRPVTIGKPIDNTQVYVLDDRMQPVPIGVPGELWIAGAGVACGY LNRPALTAERFVSNPFTPGTTLYRTGDLARWRADGEVEYLGRLDHQVKVRGFRIEMGEIEAQLAGHPSVK NCAVVAKELNGTSQLVAYCQPAGTSFDEEAIRAHLRKFLPDYMVPAHVFAVDAIPLSGNGKVDRGQLMAR PVVTRRKTSAVHARSPVEATLVELWKNVLQVNEVGVEDRFFEVGGDSVLAAVLVEEMNRRFDTRLAVTDL

FKYVNIRDMARHMEGATAQARTGATEPAREDTASERDYEGSLAVIGISCQLPGAADPWRFWKNLREGRDS VVAYRHEELRELGVPEEVLRDSRYVAVRSSIEDKECFDPQFFGLTARDASFMDPQFRLLLMHAWKAVEDA ATTPERLGPCGVFMTASNSFYHQGSPQFPADGQPVLRTADEYVLWVLAQAGSIPTMVSYKLGLKGPSLFV HTNCSSSLSALYVAQQAIAAGDCQTALVGAATVFPSANLGYLHQRGLNFSSAGRVKAFDAAADGMIAGEG VAVLVVKDAAAAVRDGDPIYCLVRKVGINNDGQDKVGFYAPSATGQAEVIRRLFDRTGIDPASIGYVEAH GTGTLLGDPVEVSALSEAFRTFTDRRGYCRLGSVKSNLGHLDTVAGLAGLIKTALSLRQGEVPPTLHVTQ VNPKLELTDSPFVIADRLAPWPSLPGPRRAAVSAFGLGGTNTHAILEHYPRDSRPRERSQRSNAVRAVAP FSARTLEALKDNLRALLDFLEDPASAEVALADITYTLQVGRVAMPERMVVTASTRDELVEGLRRGIATVG GAHVGTVVDTSPSVDADARAVAEAWATGDSIDWDSLHGDVKPARVSLPTYQFAKERYGLSPAHSVANSSK THPDAGVPLFVPTWQPWSEGASNASLALRHLVVLCEPLDALGAEGASALASTLADRRIEVVRTSSPSARL DARFMAHASAVFERVKALLSERLTAPVTLQVLVPEERDALALSGLGSLLRSVSQENPLVRGQLIRVQGSV SASALVDVLVKSARAGDVTDSRYHAGQLSRCEWREARVAKGDASRFWREDGVYVISGGTGALARLFVAEI GKRATRATVILVARASSAEAVDGGNGLRVRHLPVDVTQPNDVNAFVATVLREHGRIDGVIHAAGIRRDNY LLNKPVAEMQAVLAPKVVGLVNLDHATRELPLDFFVTFSSLAAFGNAGQSDYAAANGFMDGFAESRAALV NAGQRQGRTVSIRWPLWENGGMQLDSRSREVLMQRTGMAALGDEAGLGAFYRALELGSPGVAVWTGEAQR FRELSVSVSPAPPPHQVALDAVVSITEKVETKLKALFSEVTRYEERRIDARQPMERYGIDSIIITQMNQA LEGPYNALSKTLFFEYRTLAEVSGYLAEHRAEESAKWVAAPGENSSSVIQEARPPRADATHRAPRADEPI AVIGMSGRYPGAENLTEFWERLSRGDDCITEIPPERWSLDGFFYPDKKHAAARGMSYSKWGGFLGGFADF DPLFFNISPREATSMDPQERLFLQSCWEVLEDAGYTRDSLAQRFGSAVGVFAGITKTGYELYGAELEGRD ASVRPYTSFASVANRVSYLLDLKGPSMPVDTMCSASLTAVHMACEALQRGACVMAIAGGVNLYVHPSSYV SLSGQQMLSTDGRCRSFGAGGNGFVPGEGVGAVLLKPLSKAIADGDSIYAVIRSTSVNHGGKTNGYTVPD PQAQAALIRSALDKAGLSARDVSYLEAHGTGTELGDPIEVAGLTQAFRRDTDARAYCRIGSLKSNIGHLE AAAGIAGLTKVILQLRHKRLVPSLHAESLNANIAFGETPFVVQRGFEDWARPRVEVDGVLSERPRLAGVS SFGAGGANAHVLVEEFEMGPEKTPMRPGTPVLFPLSAKNPDRLREVGRRLCGYLFQARHVDAEHLRALGY TLQVGREAMNARLAFTARSADEAREKLEAFLRGDAGADVLLGEVDDDACAFGRARSAASQTLAQPLDESR GRELLAAWVQGREIDWGGLYGGEAPAPRRVSLPTYPFERRTYWLALKGQGVRTVSPSVLETKVEWIDAPV PETLPWRERLLSKLGGTVWVVYDEESDARRFVALLEQVSASGGVSSALQIHMHRFVRGAAVEGPRIDVGH EARATVFWLLPGAVGDTAGWLRAALPEFERWVSRGAGVTVYCLGGGTAATLEGDVGGLDAALSTMARPQD SWRCVFMEDDAHSLPSLQRFLREWIVDEGRPARSLVRYTGERRRLLQWGAMSTQSVGQVPVVQAMEPVYL LEKVWRRQPVSVSTAEGSTGSRWQAGSRVVVLVNPETAQFVSELRQALAPAEVRVVIAGALFSPEAGQAL ASELLREVGHVDVVIDVSDLYAQPRSVDDDKLGRVTFLQRLIREFSALSILHVTRGLQPFECAQPSLAGA KLVGLMKMLSAEYPHVVAKSIDLDVGAEALVELLGRELAAPREQSEVCYRRGLRFAPLLEKRRVERTDAD GLERQPFDLHETGVYVVTGGTRGIGLEIAEHLVSRGARRLVLMGATPLPSRRGPDAGGRSPQDTLRLEKL AALERRVDSLDIHIGPLDDRTALAALFTRIQRERGPIRGVIHSAGAYSDIKTPAFVDKKAVDIERVLAPK VRGIECLSDVLEGADLDFFVSFSSLTGVIPRLARGLSDYAMANAFLDHFTAYQHQGRKRTCYRTITWVDW NETGAGARLSPEDKARLDQALGSLGMRSFTNDEGRALFEKSMRLGARSWVLLAYLHPETSWAEGNPMLAE SPVTTQRRTVETPEAAPAVDSSGVKAAIRDAVCEVLQLPVDTLDDDRAFQRYGLDSISAVQLSVCLKRRL GSDVSPREFIEHPSVRSLSEYLGTQLDVAPPLPSVVPVPEHDAPAPRSQTRGGKDAQAVAIVGAAGFFPG CQSLQAFWDALDAEQTLLEEIPPNRFDYRPLFPDKSRSKWGGFIPDVASFDPGFFNILPAEAETLDPRQR LLLMAVYHCLEDAGQAPEKLKGSRTGVFVGAEENEYLLHLREQGVDTASGFDQAASMVANRLSYFFDLSG PSELVNTMCSSAAVAIHRAVLAIRSGEIDRAIVAAANVILRPDGFIKLSQLQQLSPSVRVQSFGKDASGH QRAEGVASVLLMPLEQAEREGHPIHAVLRGSAVNYNGRSGVSIAAPSRQSHSELIQSCYRSAGIDVRDVE YIEAQGMANPVADIAEWEAINDALKRLATAQGVDVVPGHCRVSSLKPLTGHMESASALGALFKVIHSFRR DKVYGIAGFESANSYLELDRQPARLATRTEPWRRNGKPRLAGLHSFGAGGNNAHLLVEEYVPQLESRPSA GGPPSRQWHVVPVSASSVEQRVDRVARLAATLRAEPELDLDAVALTLQLGRDAMKHRVAFLAEDRTRLQH QLDRYVAGERSEGVFEGSAEKSKGQRDAAAHPSLQASQREAQETAVAWCRGAVVDWQWPLEAKPQRVRLP VYAFKMQRLWVDAAPRQPREGTMPIAEHPASRPGDDTRFRARAESMIRTTLSPFLRVPPEQLDLEAEFSE LGFDSILVIKLAAALRQGHGLVVEPAAFFEYSTPAQLIQHVSDQLARDAAPPSPASDLLPHAGATAPRNT DEPIAIIGLSGRYPEAHDLTAFWSNLARGADCVSELPSDRWPLDVFFDADKDAAIASGKSYGKWGGFLGG LYDFDPLFFRISPREVEIIHPESRLFLQCAWHVVEDAGYTPTALASERVGVFVGASKVGVAEQHHTFFTI PNRVSYALNLKGPSLAIDTACSSSLVAIHLACQQLQSGDCTLAIAGGVNTYTHPYHFADLSKLQMLSTEG RSKAFGAGANGFVPGEGVGAVLLKPLGRALRDGDHIYGVIRGSEINHGGKTNGFTVPNPRAQAEVITRAL ARAKVPARHITYVEAHGTGTDLGDPIEIRGLTEAFAAQTPDLAYCRIGSVKTNIGHLEAAAGIAGLSKIL LQGQHRKYVPSLHSSTLNPHIDFGKTPFVVQQTCEDWLPCDAQGQSIPRIACISSFGAGGSNAHLIIEEA PAEAMTQDPQALVDGAALFVLSARTEEQLRTYAASFDAFLAQAPALSLQDLCYTLQVGREAMDCRLACQV GSIRELRERLSDFAQGRSTPELLTANIRKNPEGLASQDGGEAMRTGALSELGARWVKGGHVDWRSLHEGK RRRRLSLPLYPFAKQRYALPATPTAVSAVAPARLHPLLHENQSTLAGPCFVTHFSGDEPFLADHVVRGQK VLPGVGYLELAHEAVLRSLEPAERGSTAIRLEQVVWLRPFVYSAENASLTVRLSLVADESLSFRITSTGR SGETMLHAQGRARRGPGGVIAERVDIPGALAGCTRKVVNGEALYDVFQSIGIDYGPAHRVIDELAVGENR VVAKVSLRGTSLADRAAYTLPPSLLDGALQATLGLAMGQGALRTALPFSLDTLRILRPCPDQAWVVVERE PRGGANGPIVCAIRITSEAGEPCVVLEGFNARPIDSATAQPPADEQATLLWSPERVREPAPESPAPSFDH HLVLTCGMSGLTASDVERAVRDGRGSTSVSCRELQSRQERLDLRYLDFARQTLERLRETLAGTKGKLLVQ LAYAGADKVVAGLGGMLKSAALENTRLSCQSIGFDGPVSAEQLAKALLENARTPGEREVDYEGASRFVTR WHERARLPVACEADTVGAVPWRAGGVYVITGGGGGVARLMAQEIVRRCERPTLVLVGRSDAKEPLLAAFR

EWEASGARVRYFVVDVADMARMAEVVAEVRREFGTVHGVIHTAGVIEDNLLARKSEAELVRVFAPKVSGL VVLDEATRGLSLDFFVAFSSIAGALGNAGQADYAAANAFMDAYMAHRQTQVAAGDRSGVSRALNWPFWRD GGMRMDAATEEAMTLGTGMVPMPTGTAMTALYRVLTGSASRVLVTVGRVESIRKLVGQEPVSRRERAPET PNAGDLQARVEAVLLEGVSELLKVPREELDADTKLSDYGFDSITFTEFANLLNRQLSLGLSPVIFFEFTT ANALAGYLCESHGPRLLDQLGAEAAAFEPASPPSAPMPVEPARSEERVAPAQPRAREPIAVIGMAGRFPS ADDLDAFWGNLVAGKDCIREVPNSRWDWRAYDGDPIREPNKTDVKWGGFIDGIDEFDPAFFGISPREARL IDPQQRLLMMYAWKAIEDAGYAPSSLAGSNTAIYVGTGHFGYGDLIKEAGIPIEGYTSAGLVPSMGPNRL SYLLDLHGPSEPVETACSSSLVALHRAMTSLADGTCDLAIVGGVNTIVTPDGHICFSKAGMLSRDGRCKT FSDRADGYGRGEGAGFVVLKTLSRAEADGDAIHGLILGSAENHGGHANSLTSPNPASQADVLMAAYRKAG VPMSTVGFIEAHGTGTALGDPVEVTALTSAYQTLVKADGDAASAQPRCGIGSVKTNIGHLELAAGIAGVI KVLLQMKHATLVKSLGCETLNPHIRLDDTPFYVVRETAPWPRLTDRRGVELPRRAGVSSFGFGGVNAHVV LEEYVARRQETASTQVMPGTPAIIVLSAKTAERLKVQAQQLRDALRHGRYQDGELARIAYTLQVGRDEMK ERLAFTVDSLATLERQLTAFVEGTELESGLYRGTAGSRGGTAVVEEPASGLTERISRGEIAPVLESWVRG GKVRWHELHAGGRAQRIRLPTYPFSRERHWVLDTQTPAQPLRAGRVVTRATANRRAPIVLRDPSDLEAEL MDAATPKRNTVVEAPEPERPTPTAPPAAPPPPSAAASSKLREELATSLAQALYIDRAQVNAESTFVELGL DSIVGVEWIHAINKQYGLSLPVTKVYDHPNLSLFADYLARQLGPTAPPPAPPPQVEAKTVRVAPVVSSPP PSVQAVQAPAIVKKEVAPAGTVRIAVIGMSGRYPGAENLRQYWDNLRDGVSGISELPYTRWDEATAKQFR QDRNYCHRMGALSDIESFDPLFFRMSPAEAEVTDPQHRLFWQEGYRAFEDAGYAGEALDGRRCGVYLGIM GSEYATLLQRSGAQAINTTGNSYAIAAARLAYHLNLKGPAIAIDTACSSSLVATHLACQALTSHEIDMAL VGGVTLYLAPESYLAMCDAGMLSTGGACRPFDNGADGFIPGEGVGAIVLKRLEDAERDRDAILGVIIGSG TNQDGKTNGITAPSAASQMELEREVYRRFEVDPATIGYVEMHGTGTRLGDPIELEALSSVFKERTDRTQF CAIGSVKSSIGHTSAAAGVASIHKVLLAMQHGSLVPSLNYSEPNQHFDFQRSPFYVNTEHKPWKPNGHAL RRAAISSFGFSGTNAHLVLEEYPAASRPPTVSAVGPASVFVLSAKTAEQLASSAAELRRFVQTLDAGALA HLAFTLQVGRAAMEHRLAVVAGSASELSRSLEGFLHGSPGKDVFVGTALGAGPASGQAPSTDDLNVLVGV WRQSHSYAKIAAAWVRGARVDWAALHGGQGPRRISAPTYPFAKERCWLPEHASEAAAPMAHAITDAGHPL VQRNTSTLSELRFTSTFTGDEPFLAEHRVAGRRVMPAAAQLEMARAAVVALLGAGERTKRVQLANVVWPR ALVVETGATDIHIGLKPQPDGDLAFRIYSSPEYDSGMAVLFCQGTARLKTADMPGAAERSRVERNTLLRE CGVDSLDGEACYRRFRAAGLEHGPSFQALRRIHVGREQVVADLSLPASNARAAASYALPPGILDSALQAV VGLARGKDDAPAALPFGLERLDVYRPCPSEAWAHITRPAANGPDSAMPCVDIAIYDAQGTLCVELKGFVT RAPEASRESAEHGREVLLMTPAWTVSSPRVDGTSPAKPGRHIVFLCETGRALEAALRPHAGDAELIRLES SHDRMGDRVQEYAGRLLSTFKRVLKSGPQGDVLCHLVIPAKGEQQLLTALDGLLKTAHAEEPRLKTRLIE VHEPEGASLASLLFAATPGGQAPLRYTRGGWREPRWQEVAQRASSTPHSESVWRRGGVYLVTGGLGGLGM IFAQEIAARAPGATLILCGRSSPRQMEPRLATLRRSGVTVEYLRADVSQLDEVRRLIAGIREKHGALTGI IHAAGILRDGFIRHKSDAELSEVMEPKVLGVSNLDEASKDLPLELFISFSSIAGALGGVGQADYATANAY LDAYAHYRAGLVAAGQRSGRTLSINWPLWSDGGMSVGPELRDLAEQRSGLASLRAKEGLQAFYRAWETGQ PQVLVLVGEPARLREHVGQERGVSDAVPAARTPAMTGRAGQDAVSDHLKTVFGRVLKVPRQRLHDDVSLG NYGIDSINMLQVISELERDFGPLSKTLLFEHRTLGELTAHLAEAFADRLAGIFGLAPSVEQREEATRPAK REPAPRVSDGGSPTDVAIIGLAGRYPGARDLNAFWRNLREGVDSIGEVPQDRWDHSAIFDPDKSRPGKTY SKWGGFIEGAAEFDPRFFNIPPKEAHFIDPQERLFLECAYACCEDAGYTRESLAKLGGDRAGGSVGVFVG VMYQEYQLYGAQETIQGRPLSLPGNASSIANRVSYWFDFHGPSMAVDTMCSSSLTALHLAMQSLANGDCE AALVGGVNLSVHPNKYLGLSQGRFVSSKGRCESFGAGGDGYVPAEGVGAVLLKPLERAKADGDRIYGVIK ATAVNHGGRTAGFSVPNPNAQAQVIGRALRRAGVDARTVGYVEAHGTGTSLGDPVEIAGLQKAFSEFTSD KAFCAIGSVKSNIGHCESAAGIAGLTKVLLQMKHRQLVPSLHSQVLNPHIDFDGTAFVVQQRLTEWKSPV QEHEGRRVTQPRRAALSSFGAGGANAHVVFEEYVEEANPRATDRESQAPVVILLSATLEAGLQARARQLL DWMRDPELRQGSLDDVAHTLLNGREHMVERLAFVVSTFAELEAALEDFLAADGSQPKSKGKRVWRGRVER VSNGLTDALVDEDMQQTVDAWVAKRKFDKLLDLWTAGVSIDWSRLHGGSKPRKVSLPTYPFARERYWVPR FDERSTPEPKQHVELPPVPSLPREIPAPVTPRARIKLEPVGQVSVGNGVEARRLPPMPKVLTPTRSPEDA PPVVAEVREPARAPVQPVSEPPVPAPKRPAPVAPRTPAPAGVTLEQLQAELTVSLARALFLQPSEVDLDV GFRHIGLDSIISVEWIQSVNKSYGINVAATRVYDYPNIREFSKYLGNEIQKTVSAGAPAQGEPPSLDELL RQVEAGELDPSVAQQFLTNSQS TaO ER KS8 DH KR ACP KS9 DH ACP KS10 DH KR ACP KS11 MGEGHRIGVLQQPPRGRDCHEADDGSRRIPQPPVPQVGRPGRGAVMTRLEILQALQSGRMALADAKKALA AIEAQVQPEDFGLVVAGVGGVEAARLSAWAVAPPSPGDITIQVRASALNYPDVMCVRGLYPTMPEYPFVP GFEVAGVVSAVGPGVARFAVGDEVIAVTGPLLGGHASKVNVPADNAVRKPATLTFEEACSLPVVFSTVYY AFEMGKLAEGEHVLVQTATGGCGLMALQLAHLKRCICHGSSSRDDKRKVLERIGVPHVIDYTGDFAPEIR NQTGGRGVDVVLNMVSGEAIQKGIDSLAPFGRYLEIAVHALKTSPKLDLSRLVQNQTLHSIDLRRVGFAG RLGAHRLLDEMAAMASAGEIVPIVSRVYPVRKLQDALQYVSEGKHIGKVVLSHTAEEVVDRTEACIEAMV RHRKRFESSAPSKPTVPVSPPEVRTERPVTQDMEPVAVIGMAGKFPRASDLAQFWQNIARGVDCISEVPA GRWSVAEHYDADGNTPGKSYSKWLGVLEDAESFDPLFFGISPAEAERMDPQQRLFLAACWHCIEDAAIRP SSLSDTRCGVFVGCGPTDYGRDLRGGDLNAQALMGGATSILAARISYLLNLKGPCLAIETACSSSLVAIS QACDSLVLRNCDLALAGGVNVAFGPAMHIMSSDAGMLSKDGRCFTFDARANGFVPGEGVGVLLLKRLSDA VRDDDPIAGVIRGWGVNQDGKTNGITAPSAKSQAALEREVYRRFGIDADTISLVEAHGTGTRLGDPIEVE ALVESFREHSARKHYCALGSVKSNIGHLMTAAGVSGVLKVLMAMRHQSLPPTLHFEAVNPHLALEGSPFY

VNTELKPWTGVPVRRACVSSFGFSGTNAHVVLEEAPSQSRTVAGDAVSPAAPVVFTLSARTEVQLKELAQ SMAAFISATPDVDLRDLTYTLQVGREMLEHRLAILAGSREALQEALAAYLSGRPSAAVLSGQAKRTAASI SALAADEDGRVLFESWLHKGKLRRVADLWTQGVDVDWRRLYATHTPRRLRLPGYPFSKKRYSPPVVEAQA VSTVRGGAVLHPLVHRNSSVLAEQRYSSTLRGDAFYLADHQVNGRKVLPAAAYLEMARFAASDAWADEAV GRIPVLRNMVWTSPLVVDDAAEVGVALHAQDAGRLTFEIHSAPDAAGERTVHCRGLAELQERVAPRHDLR RLEADCTLRVLSREQCYETFARLGLNYGPGHRALVRVRVGHGQALGEVELPEHLVGDGRSFVLHPALVDS ALQAVVGVLGDEGGTAPALPFAVEEVVVHGPCIPRMWAVVRSGTGEGMARKLDVDLCDEQGAVRVSIHAL SLRPLPEQPSASVATGLFQMEWVPRELPAGDAGTFEHRVVILCGMQGVDVAQLSSRLDGAECVAVDASHA SVADRFLHASAQLLGVLQRVTTSRLSGKALVQMVAASGADLLLYGLSGMLKTAALEDDKIVGQTVLLAHP ASSIDQMVEVLRNEARGLGSNSVRYDEGRRLLATWKARSTDAVATASWPDSGVYVISGGAGRLGLRVAEE IAQRARGASIVLVGRSAPTSEVAARIERIAGTGTQVVYRQADVGDLTAVDALVREVRSAFGPIKAVVHAA GLLRDRYLRDKTSEELQAVAWPKVRGIVNLDLATRGEPLELFLVFSSIAGAIGNIGQADYAAANAFMDGY AAHRDALVRTGERAGRTLSVNWPFWEEGGMQVDAATAKRKVREWGLAALSSTQAFDALYRGLRTDAAQLM VLSGHLEAIQRRLTLSEEGGAHRAATGAARAVTIDDDTLRTQVRQVLMSVVSKVLKIPFEELDADAELKE MGFDSISLTDLAHQLAGEYRLDLAPTVFFEHPTINALVGRLVSEHRPLLAERHRGVAGPVADTSPEDTLP TPPVSRRSGRRSPGFSPAAVAKVPGQREPVAVVGMSGAFPGAPDLAAFWRNLAAGRDCIEEIPADRWNWR DYFGDPAAEDNKTRIRHGGFIEGVGEFDPLFFGISPSEAEIMDPQQRLLMTHVWRAIEDAGHAPQSLAGS NTAIFVGTGNTGYASLLERSGVAIKGSTATGSVPSVGPNRLSYLLDLHGPSEPIETACSSSLVAVHRALL AIELGLCDAALVGGVNTIVTPDAHIGFGKAGMLSEDGRCKAFARGADGYVRGEGVGVLYLKRLSLAERDG DHIYGLLLGSAENHGGRANSLTAPNPKAQADLIEAAWLRAGVDPRTAGYIEAHGTGTSLGDPVEINGLKS AFHSLYEKTGAAEGTDAHIGIGSVKSNIGHLELAAGVAGLVKVLLQMRHGVLAKSLHCEELNPYIALKGS PFYVVQEGRPWLALKDASGRPLPRRAGVSSFGFGGVNAHVVVEEYVPSHEATPTPLRGPAICVLSGRTEE QLRQQARQLHEAVEREGYRDEHLPALAYTLQVGRDAMEERLALLVDSIAGLQEKLRAFVDGAGAGDAVFR GHVKRNKDALSVFTGDDDLQEAIASWLSKGKYHKLLDLWTKGLSFDWNRLYGAQRPQRLSLPTYPFSRTR YWVPEGEQPAGVPTWGALRAGGVDALHPLLRRNVSDLRQQGYEAVFSADQFFLADHVILGKRVVPGVVYL EMARAALQLAEGEEAAVVRPVRVTNVTWPQPQVVEGPTTELRVSLFPEDDGRVRFDIHSGSDDTHVCHSQ GLVTFFEPKPAAAVDVAALKSQCQRGELSAEQCYQAFASLGAAYGPGHRALRAVYQGVDQVLARLVLPEG LGSTVAPYVLHPSLMDAALQATIGLSAQESPAPIGLPFSVDAVEVLAPCPPQLWVWIRNAAGSTAGGAVR KLDLDLLADDGQVCIRLKGFLMRPVKELRAAPAPRILAPAEEVDASPADAGPLGDPSSVRDQIRSVLITE VARAVKVSAGDIEINTEFSEYGFDSISLTEFTSRLNHGYGLSLTPTLFFELPTIAALSEHLAEKYRQNFD RYMVVAKRGADSGNTPAPTKAVGPKAEARRLRRMPRPSRSAEPLTYGNDEPLAVIGMSGRFPMAEDLEAY WRNLRDGVDCIQEIPASRWDWREIYGDANQEPGKTLIKWGGFIDGIDEFDPLFFGVSPSEAELMDPQQRL LMTYVWLAMEDAGYSASSLSGTRTALFIGTGQAGYGSLIEQANAEIKSYASTAAVPSVGPNRMSYFLNIK GPSEPIETACSSSLVAVHKAMLAIHRGECDTAIVGGVNTLPTPAGHIGFDKAGMLSPDGRCKTFSDQANG YVRGEGVGMLMLKRLSLAEADGDHIYGVIRGSAAGHGGRTNSPTAPSPKSQAELLHATYTQAGIDPRTVT FIEAHGTGTSLGDPIEIDGLKSAFTALDPTLGAGPVDRAFCGLGSVKTNIGHLELAAGVAGVIKVLLQMK YKTLAKSLHSEQLNRHIRLDGSPFFIVRETQPWPALEDGAGNVVPRRAGVSSFGIGGVNAHVVVEEYLPS SAPAAEVPQDAPHLIVLSAKNEARLIERARQLLHAVEQGEVSQADLPSVAYTLQVGRDAMEERLGLLARS LEELKEKLLEFTEGRGLADSVYRGHVKRHKEFLSVFADDAEMQEAVAKWMARGKLSKVLEVWTRGMPVDW AKLHGGAQLRRRSLPTYPFAKEKYWVAKPARAENRVRAGSRAALHPLVHENSSDLRGQRYSAHLTGEEFF LRDHVVGQDKVLPGVAFLEMARAAVVNASGLTPPGKVTLRNVVWSRPIIVTDAPVQVHIGLEAEQDGSVV FEIYGGTDEAPLLFCQGRARIGAGTDEEATAPCVDLSVLQSGCQDRRQSGAAVYQTFASAGLTYGPTLRA LQELSVGRGQVLARAVLPEQVLSSQGQFVLHPSLLDAALQAALGLHSDEGGQLSLPFALDALEVWDGPAP SDVWIHLRDETDGAAGKNRQKISISLCDRDGKVWVRLKGFSTRPVPAAGVRAGAENHVLLFAPIWEETAL ASAPITAARRRVLVFCGATSAVAEAAANRIQGAQKVVMGTSAASAPERFRELVQKLFEAIKGMALQAGRE ATLLQCVVSTQDTERDSLRGLLGLFKTARLEHPTLQLQMVEVDAPTDVERVVARLQSSSTAPELPHLLFQ DEKVLVTRWRELTAPAPEAPLWRKGGTYLITGGAGGLGKRFAQTIVEATEQASIVLTGRSPAGDAQRAFM ESLRRPGVRVEYRPCDVTRAEDCQALIAWVRDTFGGLNGILHAAGVIEDSLLKNKDWEAWERVLAPKVQG LTCLDEASRSERLDFFVMFSSFAGAIGNPGQSDYAAANAYMDAYARQREARVARGERFGKTLSINWPLWR EGGMHVDAATEQMMTHATGMAVLETTAGVQAFQHALEHAQSQVMILAGQAERIRKWLGRSGLLEGTSVSP SPSASATSSTAEPGDEVRARVSAMLCSEIAVVLKVDAAAVDADSELSEYGFDSITLTEFANRLNRAYELD LTPPVLFEYPSVDTLAGYLLRAHRESMVHHFGEQERGATPEVVSLAERMPAAEPVTSALRTRERRGGSRG RSVEPARTDAPSTSTPARRGPTPLAVVGMSGCFPGARDLEQFWTNLAGGVDSITEVPASRWDWRELYGDP RKEGNKTKVKWGGFIEGVEEFDPLFFGISPVEAEVMDPQQRLLMMHVWRAIEDAGYAPHSLSGTRTGIFV GTGITGYNSLVERANLAIQGYSSTAVVPSIGPNRMSYLLNLHGPSEPVETACSSSLVALHRAMEAIDSGS CDMALAGGVNTIVTPGGHIAFDKAGMLSEDGRCKTFSATANGYARGEGVGVVFLKRLADAERDGDPIYGV IRSSAENHGGRANSLTAPNPNAQSQLLQDAYRKADIDPRTIGYVEAHGTGTELGDPVEVNGLKSAFAAQI EARGGGTSLEKHCGLGSVKSNIGHLELAAGMAGVIKVLLQMKHRMLVKTLHCERLNPYIKLEDSPFFIVQ QTQDWPALMDERGQPLPRRAGVSSFGFGGVNAHVVMEEYLGNARANAAKADVPRGPVAIVLSAKNAERLR EQAAQLLDAVRSGRWSDAELPSLAYTLQVGREAMEERLAMVVDSLAALETRLQVFLTGGREGLFVGGRAG RAHPSGKGSAEAEAAVRDAVTAWKAGDASPLLGLWATGGTVDWTQLYAAPLSRTHVPAYPFARERYWISP APPREQQTLEKPVAQTRPSLIGQLRTRIGAAAIEGETVND TaP MT ACP KS12 DH KR MT ACP ER TE

MIESLPRLLGAQLEAMGCFTRLPARLDEMQASSGISPRYARWFSESVAALVRHGVLSTRDGKTYTRSGPP SRPDEVWQEWEGSRSRWTQDPNTRALTTLAETTIKALPDILVGRQLATDVLFSRGSMSLVEGVYKHNPVA DFFNDALARSVVAYAELLREQSPGARVRILEIGAGTGGATAHVLAMLRTCALDVEEYCFTDVSPAFLQHA EKTYSPGNPFLTRRLLDIDVPLEAQGIPRAHFDIVLASNVLHATPDIRRTLRNAKSALAQNGLLILNEIS HNTLFAHLTFGLLDGWWSYEDEDLRIPGCPALAPETWKAVLESEGFSSVFFPAADAHERGQQVIIAESDG VIQPISPRAQRQRAPEPRPVITDATSIEERVRDVIKACVAKSLKVPESQIQVDYSFADYGVDSIIAVNLS NAINDACGTSLPTTVLFDYNSVAALSQFIARNHGAEASRLLDDKPREAPVPPREVLRDDREAPLPVAVSS LRKTVAVATAEEPIAIVGMSARFAQSDSVEALWRHLEAGRDLVEDVRRWDLASHYASTLSGEGDRCMRGS FIEGIDRFDPSFFNISALEARCMDPQQRLFLEESYKALEDAGYAGSTPYHQRCGVYVGCANGDYATLLPR QAPAQAFWGNASSVIPARIAYFLNLQGPALAVDTACSSSLIAIHLACQGLWRRETNMALAGGVHLNSTPT FYVLSSRGGMLSRKGRCGTFSDEADGFVPGEGVGVVVLKRLSDAIADGDHVRGVIRGTGVNQDGTTNGLT APSGKSQERLEREVYERFGVNPEDIQMVEAHGTGTRLGDPIEFDALTKSFGAYTRKRGYCALGSIKTNLG HTATAAGVAGIIKVLLSMQHRKIPASLHCNATNPAIDLERSPFFVNTQTRGWDVEPGKPRCAAVSSFGFS GTNGHVILEEAPFQERRISGQAPGYLIALSAHTAAQLKALVERLAAHLKLERIDCDDISKTLLLGRRHLA HRLACVVRDERELSAALETWLAKGRAPGVHVSEVNENTRREQAEFRRYGNACIQQCAEGAPTAEYLEKLA VIADLHLQGYTLELEGLFRAGRSRRIPLPSYPFARESYWVAGETPLAERQPPPAPQRLHPMLHRNGAGPD GTGYASTLNGNEPFLADHQVNGNRVLPAVAYLEMARAAVVHRTGATSTGDIRLSNVVWSQPIVVNGVNRE IHLTLDGASEGGGAFSFEVQTAGAGQGSRAVLHSQGQAQRMALPRPQRVDLGALRAACGREVVAGGTLYT NYQRLGLQYGPAHQSVREVYVGDGQVLAEVVLPDGVAESDAYILHPSVLDGALQAIMCLHPGGDRGELPF ALKELQVFSACARPTWAWIRRSPDNEAPSGRREGMTQRYDLDLCDDQGRVAVVLRGFSTRPVLTAPVRES ADTLVGDVLVAPVWETAVIEPEVATPSATQHVLAVGATDEIAAGLAIRCGRVERLVIDEGDSIERIRDRL RGLDRIDHVVWVAPEEPLAFNEVAPRQSKGVLSLFRLVKALLSAGHGSSRLEWTVVTYRAQSTGRGDEVD PTHAAVHGLIGSMAKEYGHWKVRLVDLPDAGAWRDAALWDLPFDAQGNAVVYRQGQWHRQKLLPVDWDAF AASTPSVYRDGGVYVVIGGAGGLGGVWTEFMIRKHRAHVYWLGRRPVDADIEARLRELGALGPRPTYLRA DAADEGALREAYRKIREQHSAIHGVVHSAIVLRDQSLAAMDEDRFRASLAAKVETSIHMARVFQQEPLDF IVFFSSINSFTKAPGQSNYAAGCTFVDALASHLAQTSRCAVKTLNWGYWGNVGIVATEEYRRRMEQFGIG SLAPAEAMKALETHLCSPLEQVGMLKTTRPAALAGVSTDDRLSVQRGPARASLVASATRGAAARAAGIAE TKAAVGLEAERLAAVESLLVDLLAAQLHDMGPGVASSHRHWFTESMAILARRGYVAADGTRFLEGKVPDR EQAWARWTQSSAEWRQVPTLRAVVGLLEPALRALPDIITGKRRTTDVMFPGGRMTLVEDLYKHNPVSDFF NQATSAAVADCVAERVRSAPSAGLRVLEIGAGTGSTTASVLAALAPYRTHVAEYCFTDVSKAFLLHAREA YGAAHPFMRFQLFDVSRPLAEQDLEQGAYDIVIASNVIHATTDVRESLRNAKAALAQGGVLALNELTANT LMAHLTFGLLDGWWAFADKASRLLGGPALSPSLWKRALEREGYRSVAFPVEDAHHLGQQIVLAESDGIVR QPRAARTKALAGRGEDARHTVAAPAVASPKSTGLSGGELRTVVRDCLAACVEMAPAAVANDRRFTEYGVD SIIAVKLINAIGQRLGLVLETTLLFDHGTVDELADALVARYGAQLQVSRPLAKKAAPAPQPEVPAALGLT PSAEAPLVCRVLLERPGQADDIKRIMNTAQPLEDREVRVAVRAFSLNFGDLLCIKGLYPTMPPYPFTPGF EASGVVVEIGAAVRSLKPGDAVVAGMGEMLGAHATSIVCSESRVFLKPANLSFEEACALPAVSLTMIDAF KKADLQPGERILIQTATGGTGLIAVQLAQLQGAEIFATAGSAEKLEYLKRLGVHHCINYLEEDFEAAVKQ LTHGEGVDVVINTLSGTAIQKGVRCLRPGGRYIELAMTALKSEKSFDLSVLNDNQTFFSLDLRKLASSRP DVIARHQHEFVRLVEEGKLRATIHRTFPFSDVQSAYKALEDRKNIGKIVVTIDSPHLDTQDVSAPAAVGR STEPLDLGAFTRFQELVRLNGSTEGRPIFWFHGGMGGVEVYRALSQEIRRPFLGIQARGWMSQEAPIAGI EAMASYYVDILLAAQPEGPYELGGYSLGGMLAYEVTRQLQERGARVASIVMLDAPDSTHLDVFQFSRRTA TFQAVNTALFSSIAHHPERLEQTLIHRDEVEADLDDTALLRQLMGLAQSRGLSKDENQVRFMVEQNARVH AAYDVGRFRLKPLLRPEEVAVFYLRNGSCSFFGNLEPYLTLTPGELTFDGTNYWAEWERFLPRMQILEVA SSNHLMLLAEPAVQRVIAGFCARFYGK

Onnamide

OnnB GNAT KS1 KR MT ACP KS2 CR CR ACP ACP (ACP) KS3 ACP MENRLKHQTRNQTQKAAVEQYILTHWAEALWSQSNADLLPAADPILVDAELFLVSAAKLGFFAKTQFLSH PGHEPIDQKALHQLEKRDYQVRQARAEDLGVLQSLEALCWEEGLQTSAEGLAKRLQDYPEGQFVLVFEEQ VVGVIYSQRIADTRVLYGKNAANVAVLRRNDGPIVQLLAINISPQVQQRQWGDQLLEFMLQRCAVMHGVE AVAAVTLARDYHKQKQMPMGAYIHHRTEQGWLADPILHFHELHGADIIDLIPQYRPKDVKNEGFGVLVSY DIHHRKRRNIESRTSRNEAGGEAPSLPQREHTLEAISDYLEEAVKTILGPEQECLFSKETPLMEMGLDSA DFLGLREQIAVRFQTALEPTFFFQSKTPQDIISYFAKEMYPHPEKEAKATPLTATSVQAAPSHSRQGHIA IVGLACRLPGGIETPQALWQLLKNGESAVGSLPSGRWNWPADIDPDNRHRGIDQGGFLDDIAGFDAAFFR LSTTEVESMDPQQRMLLELSWQVLEDAGYAPKDLKKSQTGVFIGASGSDYSYLLNQSPVSVEAHFGTGSA MAVLANRISYFYDFYGPSLVVDTACSSSLVAVHKAVQSLRVGECDQVLVGGVHVMCHPANSLAYYQAGML AKDGKCKTFDQQANGYVRAEGAVMLLLKPLEAAVADQDQVFAVIRGTSCNHGGLASGLTVPNPEQQAALL QQAWRDARISPLELSYLEAHGTGTALGDPIEIQGMKDAFAGYVKARSLPVPEIRSCGLGSIKTNLGHLEA AAGIAGLLKVVLAFRHRELPPLLHFKQLNDHIDLANTPFYPVDQLRSWDVPEGAIRKAGVSSFGSGGTNS HVVLEEYPQRPARPITPKGPLIFVLSARNQENLRAYAQKFLDWLRGEKAATPPLREMIYTLQVGRQAMEQ

RLALAVSDIDDLCAQLTRFCGGHDMNDELPEMAVWWKSGEQVDWASLYKEETRPRRISLPTYPFAHEAYW PAIVQPTREVRELLLAPVWSPVPFPLTSGITPPPSKKTVVVGANPQQQQWIQQVYPQALCLEDSLRWSVQ AWEDKWRELEGVDHIIWAGSDQFPESIADEQLVQEQEAGILQVFRMVKSLLALDQDRVAISWTLITTQTQ PVHFQERINPTHAAIHGFAGCLAKEYPRWHVRLFDVAAGTAWPVQEMFACEPQQGKALAYRGSKEKGGQW FQQELLPLQTSVQGGQERLPYRQNGVYVVIGGAGGLGEIWSRWMVETYQARIIWIGRREKDDEIQGKMDA LSPAPHYIAADASDREALQRAYAEIRQCHPRIHGVVHSAVGSFDLSLAEISEERFRQILAVKVDLSLRIA QVFAQERLDFALFFSSVLSFLKSSGVSGYTAGCCFKDAFARQLAHAWSCPVKVMNWGYWRVGTGARISKA VKIRATQSGFETIDASEAMQALNRLLHGPIDQLLFLKTNNRRPLDMIQPEQTISCFESSHLSSIEAMMQR LDESPSDPQSRIKSMSAASIFKNEDMEPLLLKFLAGIVASKPVIRVPFYQNWLLQSERILREKGIANAAD FSLETCWQEWESARKDWLQDANKTAALTLVETCLRAFSDILAGKRKATDVMFPHSSMTLVEGIYKNNLVS DYFNQVLGDVLVAFMTTRGHEEPVRILEIGAGTGGTTATLLEKLRPFQEQIAAYCYTDVSKAFLFHAEEH FAPEHPFIGTAIFDVEQPLANGVIKPADYDIVIATNVLHATKNICETLRNAKAALKQHGLMLLNELSDQS LFAHLTFGLLEGWWRHEDASIRIPGSPGLFPEAWQSVLEREGFTSVCFPARAAHQLGQQIIVAESNGIVR QQPLAPGHNAPSIRQPTAGSEPRRLPGVKTQKDRSQGMLREACTHYFQTLIGKVLRIESQRIDPAESLEA YGIDSILIVQIIEALQEIFEDVSSTLFFEVQTVDALVTHFLQHQREALIALMGIDEFTDSEPSEEVVAPA ASVRGAPSNRLEREPIAIIGMSGTPDAFWEMLKNGQDCIREIPPDRWPLEGFYLADQDQAVASG KSYSKWGGFLENPFDFDARFFNISPKEAKDMDPQERIFLQAAWEALEDAGYDKKSLATRYRQRVGVFVGI TRTGFDLYGPQLWEQGNTAYPHTSFSSVANRISYLLDLRGPSMPIDTMCSSSLTAIHEACQRIQFGECEM AFAGGVNLYVHASSYVGLCASRMLSKDGRCKSFGTGSNGFVPGEGVGVVLLKPLSQAIKDHDPIHAVVRG TYVNHGGKTHGYTVPNPNAQGELIREALNRAGVHARTVSYVEAHGTGTELGDPIEVTGLTQAFRQETQDS GFCALGSVKSNIGHLESAAAMAGLTKIILQMKHGMLAPSLHARELNPKIPFEKTPFVIQQELAPWQRPTV SLDGDIKEYPRIAGISSFGAGGSNAHVILEEYIPPEHQQTAPSGRSNPSYFVPLSASNETQLRLYAQKLC DWLEQNRSRSLSCADLAYTLQVGREAMEARLGLIVRSVEELEEGLKAFLNPGTTPGHSSVAWVRGEVRKH KETIRLFTLDEDMAKAVDAWIHKRRFAKLAEFWVKGYPIDWHRLHLQQTPFRISLPTYPFIKTTYWWERT SATGQATDIKAAETTIAEAGSGVKTPSKRELQPLSSARRQLPEIEIAKPRITLPDLIGRSVKTDREMQAV GQQSQKAKTAKPHVSLSDLDRKLNGEAQPLRQTSHVVLHDDGQGIFSIQMASPNHEGVPFEAVMADLKVC FQSIQSLTEAANHNAKVVLFQGEEQFFFSGRSESRTAFMEQEIHRLPLDCRLPVIAVVRGQGKGLGCLLG SFCDVMICSRGAVLGYGRPQWPLSEEERAFFRDRFGRHLGEAILRAQVSGTTFQEKGQGMTVLPETELDD YVAALARRLSGFSQQSLMVLKKQLARDSVEHAMKLVHASTPIDGDGQGEACTTSAQPSVNLPKTQNNPQA QTPQRIRLQSQVITVDAWPNGVVLVSLCDRENKNMFSKAFLQGFDEAFEHIRGNAAYKVVIITGYDSYFA CGGTKESLQAIQQGAEKFTDTRIYGRPLECEIPVIAAIQGHALGGGWSMGMYCDQVIFSLESLYQSPYMQ FGFTPGAGSTLIFPHRFGKDFAGEILLSASAYRGSDFERQGIQMPVLPRRRVLAHAMEMANEMALSSRDE LVETKVVRCQHLRHRLEETYLQELAMHEKTYVGNPDVFAKIQMHFNDGIQVEDRLDGIQEQPCRDRESEK APVVSMQQVRQELRRFLAEELHMTPDMVEEDIEFVKMGLDSIIAVSWVQKINQAFGLALGATIVYTYTNL LDLLQHIFPEIAKAPSSTIPEPELAVSSSDSDIYPGFKPIALQPTVAAKKTGNANGSSLHAEKQKPTPAG RPDGAIGQGDLKDVHVKLRQLLAEELHMTPEAVEDDVSFVEMGLDSIIAVSWIQKINQAYGLSLEATVVY TYTTLLDLAQHIFPETATTVFTSTTRQPSANAVGEPEEKAVAMMAELRQLLAEELHMAAEAIEDDVNFVE MGLDYVMAGSWVQKLNQAYGLSLEATVIYTYTNLLDLAGHLASEMSHRLATARPLAKLERERPRRTPRAD AKPVVSPPASQPLTPVSKRWLPEQKTGRIAIIGISGKFPKASTLDQFWENIAEGRNCVSEVPESRWSVDE FYDADGKVPGKTMSKWMGILEEVDQFDPLFFAISPRDAELMDPQQRLFLQACWSCIEDAGYNPKTLSGSS CGVFVGCDMGDYGRSVQYQELDAQSLLGGVVSILPARISYFLNLQGPCLAVDTACSSSLTAIANACDSLL LGHSDCAVAGGVCVMTGPEIHIMMSKAGMLSPNGTCFTFDQRANGFVPGEGVGAMFLKRYEDAVADGDPI YAVLRGWGINQDGKTNGITAPNARSQTRLEKRVYEQCGIHPEDIQLIEAHGTGTKLGDPIEVEGLRDAFA HFTEKQHYCALGSVKSNIGHLATAAGVSGMIKLVLALQHQKLPPTVNHEKLNEHIRLEGSPFYINTACRD WVVPEGKTRCAAISSFGFSGTNVHMVVEEHQPTENRRLTDAAPYLIVLSAKSDPQLEASLQQLLGFTRKH TEHAETTLHIADLAYTLQTGREAMTERLGLLVSSLDELADKLDMLLQQKSCDQIADCYRGTVIKQNIETF SSLADEDDIASWITKRQYAKVLNLWVHGAEIPWNSLYETVACMPSRIHMPTYPFAKERYWVARRKETGML TEQNHEQREPTSEKADHEFFWKIEELIEEWERQQQYGGHLTPETLTKVFAYEVVKNLGPEQIHRVDQLLA ATPKPATAPPPPVQQAAAVVPEPKLVRSEDIPQAVCEAISEVLKLQTIGEHDRFQDYGLDSISAMKLSVR LEEKLGRKVRPQWIHDFPSVGTLSRRLMEQDELVDA OnnI (KS4) C A PCP KS5 KR ACP KS6 KR MT ACP ACP KS7... MSRHQELERIKDQIFSAVLEDTPNMSTPLAGGRENLYREREESVASSLANIQRKLFDEAGDDACEFKENK ENRRLEPIAIIGLSGSLPKSQTIAEFWRSLDQDLSLIEEIPRSRFNWEEVYDPDGKDVDKMRTKWGGFLR DIYGFDPHFFKILPRDAAVMDPRQRLLLMSVYQTLADAGYAPETFKKSKTGVFFSIQDNEYLQLLREGGV DRGEGFGHASMIANRIAYFFDFRGPSEFVDAQCAGAAVALYRAVSTLRSGDITYAVVGAANLLLRAEPFA VLTRANQLSPTNCVNSFGKDAQGHLRAEGVVSLLLKPLSKAEADGDPIYALIKNTACNYNGQGGMSIAAP NVDSHAELIETCYEQVQVDPGEIRYIEAQGMGNPLSDLGEWHAYNQALQSMAKKRGVVLPQGQCAISTLK PMMGHMESVSSLGAIMKVIRSFKTNTIHKILNVQEISPDLDPQGMPCRLLTETEPWPEQARPRLAGLHSF GIGGNNVHILLEEYKAEPDCRAERGEIRLDEPRLVVLSAKTERSLLGIAGELRTFLLDATGTSQPSLFLG DLAYTLHMGRDAMACRVAFVVRTLSELINGLGHYLSRQETQDGDVPIYVGNTEDGAEHIQPLLLRENAAR MQEALFAERDLEKMALYWTLGGKLSWERLYQGERVRRISLPSYHFNKKVYVFSSQTQDVDLKSQSIETPV ETSAPQPVLQQDNVLEKKPLPETRSTETSSCGSPREQQVLAEEMKDYLVAELSKELELPANEIKVDCHLQ DYGIDSMVGMRLCRGLTERFGVEVLGREMFRHPTIDSLSAYLAQKVTGQQTSEATLPKTEPVVAAEIDHT

PYDLSEGQKGLWVLQKMVPGMSAYNVPLGFRTQCALDTERFRQTCQFFLDQYPILNTVIKETENGLCQQI SRDKQLSIQHEDISSLDSWQIPAYLQEKNNIPFDLANGPLVRFHLLKRSQQEWFVLISVHHIVFDGSSFL PAINTILKGYQTLSQGGTPLPTSFEASYRDFVRWEQQMLAGADGEKHRAYWKQQLSGKMPILNLPTDRPH SAVQSFRGAVHSMTLPGEASRHINAFSRELRINPSTFLLGVFKLFLYLYTKQDDVIVGMPNMGRPQKRFG DLMGYFINMLPIRSRKLAELSFRDFVEELQLTMLDAFDHASYPFSSMIQDSKITLSNEHSPVFQVAFEYQ NVLSPTDVQDFQAQYQDSLPMAFVQGVHQMGEYEIVLEVLEEENAFILNLKYNPDLFDATTMTRMLEQYE VLCDKVIGDPHQKNADYSLLSSKEERLLLSDWNDTSSAYPSDCVHELFERQAETNPAAIAVMCEGKSLTY GELDQRSSVLAKQLQDLGIGPDQLVAICVTRSLDMIVGLLGILKAGGAYVPLDPEYPTERLAYMLEDSQA EVVLTQTALRHQVTALSSGAARRPHILAVNEVLEAWNGEAISKGTLRREVQNTHLAYVIYTSGSTGKPKG VMIPHNALINFLTSMAKEPGLNSNDRLLAVTTYCFDIAGLEFYLPLIMGAQCVICSSETIVDADRLKQEI SHCRPTVMQATPSTWSMLFHCGWKNEEKVKVLCGGEALPMALQHQFMACNCEVWNLYGPTETTIWSAVQR IRENEAIVIGKPIQNTGIYILDHNRALVPIGVPGELCIDGDGLARGYLHKPELTAEKFMDHPFHRGKKIY HTGDLARWLPNGTIEYLGRLDLQVKIRGFRIELGEIEFQLKQLPGIRDAVVVAKDMAKDMEGLHQLVAYF IPGGGPESVDTEVLRAGLKQKLADYMVPAFFIPLEEIPLTPNGKVDRKTLMERDILVNRSQEHTQPQSAI EESLLEIWQDILKIDNISPTDGFFALGGNSVLAVRLAERIAQTLGMPFNPTALFKHASIREIGHYYRSAN QQTSSVSHGGAEPQKTPDATQSGDDYPDYYQDSVAIVGISCHFPGAADHHTFWRNLRDGKESASFFPEEE LRAAHVPEARIYNPNYVPLKLTIEGKDLFDAEFFNISPANAVYMDPQLRLLLTHSWQAMEDAGYCARDIP DTAVFMSACNSFYKTLLHRANAIGEADEYAAWIASQSGTIPTMISYQLGLKGPSAFVHTNCSSSLSGLYF AVQSLQTGQAKAALVGAATVFPLPGIGYVHQPGLNVSSDGHIRTFDAAADGLTGGEGVGVIMVKKAQDAI ADGDHIYALLRGISLNNDGSDKTGFYAPSVKGQSEVIGKVLRATNVDPSSISYMEAHGTGTRLGDPIEVM ALSDAYRQFTSQTQFCGIGSVKPNIGHLDTAAGLAGCIKVALSLSHGEIPPSINYRQPNPEIDFKTSPFY VVDQLQAWKTDAVPRRAALSAFGIGGTNVHAIMEEFVVPASAENRRLSDGPYLVALAAKNPERLRAYAQK LLAFVKADAGKRDDQPLNLADLTFTLQTGREAMEERVVFVVCEQHELVAMLDAFIAGKERISGCYTGSAR HAGNVLRILGDEDAHELIQRWTETGKHAKLAELWVNGIAIDWKALYRGHSPRRISAPTYPFAGVSYWVEE ETAALSRTSPSQHLASRGVLMRLPQWQDKAISHTDHGVSAAHHLILWAGNGMAPVAQRENTSVIHLQSQG PTAAERFLDYSVQAFESIKQIREQHRGPVFIQLLFPSHGEKQLVAGLGGLLKTAHRENPKTTYQLIEWDV EAPNREALLEILQENSLCAGDAHVRYCQGQRQVLVWQEVTHQSQPAIPWKDRGVYLITGGAGRLGILFAR EIAQQTTGATLVLVGRSELGGQSLGQIQQLESLGASVVYRQVDVSRREAVTALIYDVGENVGEINGILHC AGVIQDNFMVKKQVEEWRSVLAPKVTGAVNLDLATRHCPLDFFVLFSSAAGAIGSPGQADYATANAFLDA YAGYRNRLVTAHRDQADGPRGFTLAMGWPLWQEGGMRADAVSEKITRETTGMLPMQTANGIRALYQCLAL GQSQVMVMEGHLPTLRAFLGAGQLANPEGAEKPERVVAEIDDQELATRTLQEMKTLLGSVIGLVPDEIDA QKPLENYGLDSIAIIQLNEKLDGVFADLSKTLFYEYQTLDELVDSLLADCPHACRTWVGRFEAPPVREPE PETETVNGLCEPASQVPQPHARSAKKSCGNSVQQEPIAIIGISGRYAQADTLDDFWHNLKAGKDCVTEIP QERWSLDDFYLADREAAVAQGKSYSKWGSFLDGFADFDARFFAIAPREVRSLDPQERLFLQCSWEALEDA GYTRESLQRHHQRNVGVFVGITKTGFDFYEPELLAQGETLHPHTSFGSVANRVSYFLNLQGPSMPIDTMC SSALTAIHEACEHLRHGACELAIAGGVNLYVHPLSYVRLCSARMLSGDGRCKSFGEGGNGFVPGEGVGAV LLKPLSAAIRDRDHIWAVIRGSGVNHDGKTNGYTVPNPNAQGQLIADTLKKAGVPARAISYVEAHGTGTE LGDPIEVTGLTQAFSQDTNDRGFCALGSVKSSLGHLEAAAGMAGLTKIVLQMKHGQIVPSLHARVLNPNI NFDKTPFVVQQELGIWKRPQIEINGMVQEIPRMAGLSSFGAGGANAHLIIEEYVANRQEMASLTERPGPY AILLSAKNEIRLEEVVENLRQFLIAQSRDGQGSDLERVAYTLQVGREAMEERLGLVVDSVDELQDKLERF LAGEMHVEGLYRGRVQRGAQAEIGQEKVDAWLEQRLFSKLLDLWTKGMSLDWSKCYGAVGSHEMPYRMSL PTYPFAKERYWIQPQSRELRDNEAAEGPQVEPLTLAPLWHTVSNLESQPIFPAEDTRIVIMGGTHEQHQT IRATFPNARSLQLDPEASCEQIAAQLGAMTSLEHIVWITSDRPWQSVASESIPEEQNHGVLLLFRLVKAL LALKFGDRELGWTLITTHAQSVWQQGALNPNQASIHGFAGSMAKEYPHWQIRLVDLEASAAWPVQQMWRV PAHAQGEALVYRGHEWFRRTLAPVHTQVEKASLYRKNGVYVVIGGAGGLGQIWSKAMIEQYQAHIIWIGR RKKDEAIQAALDHLASNIGPAPSYIAADARNYHELQAAYEQIRQEHPHIHGVVHAALGPYDQRLFDMGED QFRAMFSVKVDVSVRLAQVFKREPLDFILFFSSMIAFGKSAGMAAYSAGCAFKDAFALQLSREMPGAVAV KVLNWGYWNVGGGTRISASLKRRVAQSGVQSITADEGMEAVDRLLSGPVKQLAFTKTAKPGLIETLDATE RIIHYRERGRSCAPTLQQYRPHGEAPVISPRADELNAWMVKLLFVQLHDLGIFQSGHAAHQETVRKHMQI LDKYERWWLESLKLLENYGFIRLEDGRIQAREEAAVEDTQTVWAAWEASRQAFLQTSETRTLAVLVHDCL LRLPDILRGTLLVTDVLFPNGSMEKIEGLYKNNHVCDYFNQVVAEVVQTYIHQRLAVNPKATIRILEIGA GTGGTTSMVLPALRPFQDHIDTYSYTDLSKSFFIHAKERYGTAYPFVEYKILNIEKPLAKQDVTLLGSYD IAIATNVLHATKSMRNTIRNVKAALARNGIAIINEMTTKTVFATVLFGLIDGWSLSEDTVLRIPGSPGLY AETWHQLLEEEGFRSILFPAHPARELGQQVIVSESNGVVRQKTGNPLSQAMEVVEEEVGAPGDEDPCREQ VTQLVLSQLAQTLEVPENCIDLDVPFSDYGVDSILGVNFITQINDHMGIEMNTTVIFDHTTVHDLTAHIT RTYSDRIGLSNAPQLEVPDHGELVHRLVVSHLAKVLDVAESTIEGDVPFSDYGLDSILGVNFITQINDDL GLEMNTTVIFDHTSVNALADHISKTFQGDLNIREKVKETGDLKKGITDEPKWEPDPPADMSVEFGEKDFG SSSPRIAIIGMSGQFPGAKDMESFWQNLISGDDPIGELPPHYLPPESFSPDPLPGKSYCKWGGILEDRDC FDPLFFKLSPREAESMNPHQRLILQESWKALEVAGYAPKSLNGSQTGVFVGSEPTGYVHETFTGSSEAII ASRLSYFLNLRGPAFVVNTGCSSSAVAIHLACESLRHNESDMALAGGVFAAMNPTVLISLSQAGMLSASG SCRCNPCAA//

Pederin

PedI GNAT ACP KS1 KR MT ACP KS2 CR CR ACP ACP KS3 ? KR ACP MSAARMGLFPRCPLTASLTDLEEFRQHFLESLEAKPYRVRPASMKDMKVLLALEERCWDIPLRTPRGVLERRVSRYPQGQLVLTLDDKVGGIIYSQRIEDTKVLQGVSMAQVDALHRAQAPIVQLLAINIEPVCQQYNLGDQLLEFMLIYSALLEHVQGIVAITRCKQFDQANGITLEDYIHFRNDQNVLADPILRFHELHGANIVGPMWGYRPGDTKNLGCGVLVSYDTRQRVRRELQWEALSAEGEKPVRVSRSRICSQVCASISDALGEARKSVFATDRPLMEMGLDSADLLGLKEAISSHFKLALEPTFFFRCNTADKIIDYLNQHFGAALGEDTEESRPTSATRFGVGQMSRDDVAIVGMACRLPGGVDSPTAFWQCLQEGASLIGDLPVERWEWPDDIDPQRAHKGIARGGFIEDVKAFDAPFFRISPAEAQSMDPQQRMLLELCWQTIEHAGYAPDALAGTDTGVFIGASGSDYARLLERSESPLDAHYGTGSSMAVLANRLSYFYDFTGPSLLLDTACSSSLVAVHKAVQSIWAGESVQALVGGVNLILHPANSIAYYKAGMLAKDGLCKTFDQQADGYVRGEGAVMLLLKPLARALESRDRVYAVIKGTACNHGGQAGGLTVPNPERQSTLLCSAWQSAGIDPSDLGYIEAHGTGTSLGDPIEVRGLKDAFAATRCGAGQNCGLGSVKTNLGHLEAAAGIAGLLKVVLCLQHRQLPASLHFQQLNAHIELERGLYVVDRLQPWTPPSSGRVRFAGVSSFGSGGANAHVVVAEAPDIRVAPDGVADRRPSVFVLSAGTQAQLRAYAQIYIDWLSAKGQDNLPLTHLVYQLQTGRKAMAHRLALVVDSYEALLSGLKAFCTRSESQVADTPASTRREASRQYIHSLVEEGEWEQIAWLWQSGDDVDWSLLHDPRVPMPRVALPTYPFARQHYWLPESTMASSRQASVGKTELLMLAPCWKPLQLIDGSEQRLVTASASKRVLVVGGTDDEWDTLRALYADSWRIPIDPDVGVGELSSRLGELGELAQVMWIAPAAEGSNMTGQTLLCCQALGVRYLFKLIKALLAQSYGERPLGFTVLTRNTQSVFCGESPEPAHAGVHGFVGSLTKEYPHWTVLALDLDETFDTPVKTLPQLPVERRGECLAWRDGQWFERFFSPLEKYSPMTPAYRQGGVYVVIGGGGGIGAAWTRYVVERXAATVIWIGRRALDAGVEAQRQTLADLAGMVDYVQADASDPAALQAAYERIRQKYPAVHGVIQSATGVFDQSLAEMEEVRYQEILSSKIDISINLAQVFEVEPLDFMLFFSSIVALEKNGGLSGYATGGAFEDAFALHLAKRMSTVVKVVNWGYWAIGTGATISDAVKVRLQQSGGVPISSEEAMLALETILSLPLDQVALLKTSRLELLDWVDAGQQICIYPHIAAECIENIEPASSITDQVESLRALSLFNNPDMEVRLLPLLAGTLDSLGLLEGGDGQIGERAAGFYQKWLAASRRILATRGPSEPPRDLEALWKTWEETKRGGNLQHPQIAAAVALAEVCLRALPDILRGKVRAIDVLFPDASMERVQGIYRDNAVADYFNGMLADAVVAAVEARLRQEPEARLRLLEIGAGTGGSTALILPRIAAYQEHIAEYAYTDVSKAFLFHAEEHFVQSYPFVQPKLFDVEKPVADQAMETQWYDVAIATNVLHATHDIRQTLANTKATLRKHGLLLLNEVSTPSLFAHLTFGLLEGWWLTRDPSLRMLDAPGLYPQDWHRVLKQEGFAKVLFMAEQTHVLGQQVLVAQSDGVVRQPAPSCSVSDQQLLPSAPWLDVDEVVPVAVVGQTLKQASYVHLKKIVARILRMDSGELAVREPLETYGIDSILIVQITNALREVFPEIPSTLLFECQTLDALSDYLIREHQERLIALTGLRAPSAGLDQSGRSGERMVSSSISAPSSEQEAIAVIGMSGRFASAADLDEYWQLLAAGESCISEVPAERWAVEDFFHPDPDEAIVQGKSYSKWGGFLQGVTEFDPLFFNISPKEARSIDPQERLFLRASWEVLEDAGYTRERLTKDFQQQLGVFAGITRTGFDLFGPELWRQGYTVYPHTSFSSVANRVSYFLNARGPSVPVDTMCSSSLTAVHQACQSLRNGECRMAIAGGVNVYLHPSGYVGLSAAHMLSKDGVCRSFGKGANGFVPGEGVGAVLLKPLSQALADNDQIHAIIRSTQVNHGGKTNGYTVPNPLAQAELIRRALDKAGLNARAVSYVEAHGTGTDLGDPIEVSGLTQAFRHDIQENGFCALGSVKSNIGHLEAAAGIAGMIKVILQMRHGQLVPSLNAAEINPNIDFSRTPFVLQRELAPWTPPYTLGQNGEREEGTRIAGVSSFGAGGGNAHVILEEYRRPQLVAAEQPEPECLVVLSARSEERLRAYLEKLHEFVAKRIEENTAPALADLAYTLQVGREPMEFRLGLVARSISYLQNRLWSCLQGTGETQDVYRGQVKQHKELIEAFSSDPAIQQSLDAWFDQRQYDKLLDYWSKGLNIDWEKLYSTQATRHPHRISLPTYPFAATRYWLPSPSLPREVPVSAEPALPAVDSVPPITAPASSTHVVVLRAPGSVEAPPSEAGLEVRHVSLKPLSLVEGEAVVNDEEGTQTDLSLSLQDEGDGIVSLKLAGLKAASISLVGACTALTRCIRRIHRLVKDKKPAEQAGVVPRVLLLTGLGELFALREDGQGKPAVTAVVEAIADIPIPVLVVLEGDNSFNAMIVATSSDLMILSEEGAYHFASPSMSEREHCLFVERFGLRSTEELLRAEVLAGRSLNSVGIKAVIVERDRLFEYAVQTARHIAQASATALSELKRHWSTTSIQRIEAFEPRLDHGFVFTPGDSSEVPEPVPFNSEVARLSRYRNGVLLMTLCERQSKNTFSRIFVEGVIGAFEHISGNPSYKVVVLTGYDNYFACGGTKQGLLDIQSGKARFTDEQSYRMPLSCDIPVIAAMQGHAIGAGWAMGLFCDCSVYSEESIYQSPYMRYDFTPGAGSTLIFPLRLGHDLSREVLLTAREFHGRELRRRGIDMPVLPRRQVLAYALSLAAHLAITSRQQLVEQKNRRVQPVRELLPRFFEQELAMHEKTFVGNQQVIEKLNRHFYDTLHEQENAPMPAHNDAQTTEAAVRDPEQKVYAVIRDSLAEELQMDGADIDPDTAFVEMGLDSIVAVTWVRKLNKAFGLSIGATKVYSYPDLTQFARFVAQQLPELPSEAPISKVVTVKNEVIAGKAKADGAGDVDRELLAWLKSSLSTELLLEDQPLDEEARFVDVGLDSITAVTWIKAINQRYGLSIGATKVYSYSCLAEFSQYVRSLIAAAQPAAVASRAPAESDRAESLLLRRFEPDVTNQPREEQEEASTQDEPIVRLLPCA

PPVRQPTDIPAIAIIGMSGQFPQAPDVKAFWRNIVEGRDCVSEIPAERWSIEEYYDSDRNADGKTVCRRMGALSDREVFDPLFFNISPSEAELMDPQQRLFLLNSWHCIEDAGYDPTRLSGSLCGIFVGCAASDYSQLAESQTQTAQGLLGESVAMLPARVAYYLNLQGPCLAIDTACSASLVALASACDSLVLGNSDVALAGGVYVINGPDIQVKMSKAGMLSPDGRCFSFDQRGNGFVPGEGVGVLMLKRLEQAQRDGDDIYAVIRGWGVNQDGKTNGITAPNQESQTRLETGIYRKFGINPEHIQLVEAHGTATRLGDPIEVEALSESFRRFSDRKQYCALGSVKSNIGHLATAAGVTSVIKSALALQHRILPPTINFQTLNEHIRLQDSPFYINTERRLWEMPQGHSRQVAVSSFGFSGTNAHMVLEEPEPRAFVEDDTGVPDGDAILLPLSARSEEQLSRYAQAVCDYLADEGRAVRLVDIALTYQQGRTALPCRLAVIAHSVEELHARLAGYVSACASDPFCLTGWTSSQKVSCAQACRAGTGVPALLALAKAWVEGASVDWPVPTGTQARRLHGLPVYPFARERYWIAAPANLKRSGGNTLQRLHDADDVRALIASGSWWEKALPDEIDWKECLHRHSDRQVLVLYGELDQFLAFQRLLQQLQQAGDIECIAHVSCVGVADDEIEMKIKAQPDMVLLLSEDIQTLKRGLEVIERLDDANLEHIVFFVSADSLDIDELVAPIEQAGLSEHKHCHVISYQLGSDRNAAAQCLFREWLNIEVSAGSFASLVRVHYVGDQRLVSAEPVMAVTTDPIYQIHKKWHAKPLSASAPAGVRGAVLLMVNRESLQIVRNMFAPDDFSELILLGDASIQSNQIQNAINFSDARSATASAHILLERYSGLSHVIDLMDFYETAKGHDDDKQGKVAFYQVLIGACIDLSILYCTKGLQPFQNDRPSLAGAKFAGLIKMLSADYRHVKACSLDVDEAAYKRPWQLREMILREFAAPLRETEVCYRDGQRFVPVLSSQYLTQRVAVPLRLSRDGVYVISGGTNGVGLEIAGYLLSKGCTKLVLMGVKALPPRRKWAQVLGEKEVSGYIRDKLTRLLELEKMVDVLRVYTGSLSNAHALQHYFKKIRAELGPIKGVIHSAGVYSDPHTPGFVNKNLERMRHVWEPKVNGLETLSEVFKSDTLEFFVSFSSVTGVLPRLARGASDYAMANAFVDFFMQYQARSSNLCYKTILWSDWEQTGAITRLSNEKAAAIKENFRNLGIRTFTNQEGCELFERAMACVGEAWVFIGLLDPERFEQSRPHLLYAQLEAKERDSDTPSLAEELRAVVQANPTIEEYIEQWEAQVRAGQKLSSDTITEVISMDEIKRLEPELIQRIHELLVVGHDAASSSSGIAQVIVNTVMEVLKLKKLDPTQPFQNYGLDSISAMVLATRLEKRLNQQVQPQWLIDFASVEALSAHLLSQSRRRTGDRSAMQETAQ PedF (KS4) ACP C A PCP KS5 KR ACP KS6 KR MT ACP KS7 DH DH KR ACP KS8 KR ACP KS9 (DH) MSVNIHQQLKEIEDALLNNSGVAVTLDVESSDKLRKREAEDSPEAIAIVGLSGYFPQSASVDEFWRHLDQDATLIEEIPDSRFDWRKVFDPTGERPGSSCSKWGGFIPDIRGFDPAFFNIPGAEAITLDPRQRLLLMSAYQTLNDAGYASQALRQSKTGVFVALQDNEYLQLLADAGIDPGQWYAQTCLLANRISYFFDWRGTSEVVDAQCPGAAVAIHRAVSALRNGEIELALVGAANLLLRPEPFVLLSESGQLSESASVHSFGAQAQGHLRAEGVCSLLLKPLTKALADGDPIYASIKHSAVNFNGQGGASIAAPNVDSHVDLIKSCYQQARVDPRQVRYIEAQGMGNVLADLVEWQAFNRALTDIARQQRVSLPPGNCLISTLKPMMGHMESASALGALFKVIRSLHTRTIHKIAHFTQYHPDMDYQGQPCAIAGETVAWPQMEGLRLAGIHCYGMGGVNAHLLVEESVAGYYDDSELGTVSSLLEHVLIVLSAKTSESLRMMARRLQQFLQKADAVPALRDIAYTLQVGRDAFEHRLALVVDSQQQLIEGLECYLEERQPSQGEGAVYQGQVASESQSLPFTEDDLAAVARCWVAGGAVLWPVPVGPKKPRRVRLPAYPFDKRAYWVDSAVVEAERAPNSKAPASMLSGERSIGDYLRAKLGEVLQVPVERIDPQQHLYDLGVDSIVAMKLLRNLARAFGIPVRGRDLLQYSTVQALSRHLAQYLDRDQVESVGEDEEPRQLMASRRCSLSEGQKGLWVLQQLASRMTAYNIPLCVRIAQVLDITALREAFAWLLEQYPILTSVFVQDNGELFRECHVAAALPFWQEETNTLDQAQVRMRLKCLAKQPFELEKGPLVRLHVLSCGEHDHYLLLCVHHIVFDGGSFLPVFGGLLQTYQLISQGQTLAKSTRTGEQYADFVLWEQRMLASAEGQRHRAYWKRQLSGELPVLSLFTDNPRDAGQRFTGDTYGFQLDVNLSRKIRNFAKQQRLNLSTLFLALFKLLLHRYSGQSELIIGMPEQGRSEERFEGVVGYFVNMLPIRSRGVGSKPLAEFARDLQLSMADAMDHAVYPFPVMVRDLGRAPAEDLAPIFQVAFEYQNVFSAQDLRLFNQSYRESLGVTFLEEFVQEGEYELALEVREGEIDFALNLKFNPTLYRMATIARMAEHLLILAEHAIDAPLSPCRELTMLSERERHLLLHEWNATTEPYPSCCFHQLFEKQARAMPQAIAAIFQEQRLSYAELDERSERLAIYLQQCGVQPNRIVAVCLERSLDMLVALIGIARSGAAWLPLDPNYPDDRLRFMLSDSQAQLLLTEEGLRDKTAAIVSQAVGERLQIVAMDGHWPEIERQARTSELQMRDDPRNLAYVIYTSGSTGIPKGVMIEHRSLVNFLYSMLNRPGLRANDRLLAVTTYCFDIAGLELLVPLLCGACCCICATDKLNDSEALQGEIERLQPTVMQATPSTWTLLFHGGWNNRQGVKILCGGEPLPPALRQRFAESASQTWNLFGPTETTIWSTVSRLDLTKDSVDIGTPIANTRVYILNGDDQLVPIGVPGELCIAGDGLARGYLGNPQLTAQKFIANPFEPGNRLYRTGDLARWREDGVLEHLGRLDQQVKVRGYRIELSDIETWLNRHPSVAQSLVVGHEQAGGMLLVAYYVKDSEWASVSSTELRNYLAEHLPEYMVPAFFRALSNMPLMPNGKVDRKALSARELVAEESESGGRLPCS

DIEREVLDIWRSLLAVEGIGVSVGFFEVGGNSILSVMLAQQISEAFGIRFAATDLFKYPTIRDISLLIGETRERSETKTGTMAGDGSGKADSVLQAQARGRQSVTGYPDYYQDSLAIIGISCNMPGARTLRQFWENLRQGKESSTRLSERELRRAGVPEELIRHPDFVPMQY SMEGKELFDPDFFNLSAKNALFMDPQYRVLLQQAWQAIEDAGYVAQDIPETAVFMSASNNFYKTLLHSAGAVETTDEYAAWIAGQGGTIPTMISYQLGFKGPSFAVHSNCSSSLVGLYLASQCLRLKEAKYALVGGATLFPVAGTGHLYTPDMNLSSDGHCKAFDADADGLVGGEGAVVLMVRKALDAIRDGDPIYALIRGVAVNNDGSDKVGFYAPSVNGQAAVIQKALDITGVDPQSVAYVEAHGTGTRLGDPVEIMALNEVYRRYTEKRQFCRIGSVKPNIGHLDTVAGLAGMLKVVLSLKHAEFFPSINYREPNPAIDFTSSPFEVVTQLTPWPAGNEPRRAALSSFGIGGTNTHAILEEYVARTDADRWEDNQGVPLPEQVVVLSAKTQDRLQASVVKLYEYLLRAQATTEQLDLQDLAYTLQVGRQAMDWRVAFLVKDLHDLSEKLERFLQGDSLVQDCFQGRVATSVMDAAATPLPVAQDREQAAIAKAWVTGRLVDWKELPRRGTPHRISLPTYPFAEERYWVEMPELPGRSESEEQTKEWIEGQAERTLLVVHPLWQAHAVVKRERPLIFTEHLVWLCGFDVSLVRALTRCLPEGYRIVSLTPEGRGVAQRYQSLCLQMLERLQKCIGDATKLTLIQLVLPDEGEYSLFSGLHALLKTVSQENPQKVAQLIRVSSGETARSLADKLIENTFAPDDSHLRYAPSRMRLDWQTLRQEETVLDMPWKEGGVYLLTGGAGGLGVLFAEEIARRVRKATLVLVQRSPLSAAARRAERIAALRSDSITVICRQADISCATSCSQLIADIAEQCGTIDGILHTAGVVRDAFILNKSAAEFQEVLAAKVAGTVNLDRATQALGLDFFLLFSSAAAAFGNAGQADYCAANAFLDAYAYERNQRVAAGQCRGHTLSVGWPLWRDGGMRLNEEAQQAMRYTTGLVPMDSRSGIRGLYRSLAARLGHTLVLEGDATAIGSLLANGTARSVSELGVPAANGNDLDETLKDKTIYQLKRLLAQVIGRAVERIESCEPMDRYGLDSIAITQLNRKLEEQFGGLSKTLFYQYQTVEALAEYLVLNKTVSCRAWTGLRDESVLVADAARRGLPLPETAPVVERNVLPVGNAVQEPIAIIGLSGRYPQAETLEEFWENLQAGKDCVSEIPEDRWRLENFFHPDPKEAVAQGKSYSKWGGFIEGFAEFDPLFFNISPREALAMDPQERLFLQCAWHVLEDAGYTRQSLQQGGHKVGVFVGITKTGFDLYGPELWHRGERLFPHTSFSSVANRVSYCLNLKGPSMPIDTMCSSSLTAIHEACQHLRQGDCDMAIVGGVNMYVHPSTYVGLCSAYMLSRDGQCRSFGQGGNGFVPGEGIGAVLLKPLARAQEDDDLIHAVIRSSSVNHGGRTNGYTVPNPNAQAELIGDCLKKAGVDARSIGYIEAHGTGTELGDPIEVNGLAQAFGQEAGEHSRCFLGSVKSNLGHLEAAAGMAGLTKVILQMRHGQIVPSLHAQVLNPNIDFAATPFTVPQQLVEWRRTILQESGRSRELPRRAGLSSFGAGGSNAHLILEEYIAPEPAQRPRFGEPGTAAVILLSAKTPECLRRVVSDLLAFIESELTRTVDPDQTLFDIAYTLQVGREALDERLGLVAVSLQELSRQLAAFLGEEAEQPLLYRGRVQRNKDALQALANDEEFQETVDKWLARRKYSKLLKFWVTGLSVDWTRLYSDVLPRRIRLPVYPFVRQRYWLDAYSLEPMVPTEQPSVVPVDAEVSGSDAGREADLMMLGPVWDAVVEQGTEDFPPAGARIAMVGGSEAQKRAVFEQYPKALELAAGAVGAASIARLGRLDHVVWFAPASQTQGMADERIIDAQRDGVLALFQLVKVLLAEGYGVAEFGMTVITTQALATCDTE RIDPTHAAVHGLVGSLAKEYPKWRLRALDIDARAEWPVPGLWRLLPHTRGESRVWRGCEWLRQRLVALNGMPVAKGRAYRRQGVYVVIGGAGGLGMTWSRMMIRDHQAQIVWLGRSAKDATVRAKLDEVADDGLAPDYWQIDARDADALRQTFRQVRERYGQIHGVIVSTLGDYDQSVAQMSEALFREILSSKLDIGVRLSQCLRDEALDFVVFFSSMVAFGRSGGMAAYSAACAFNDTFARQLGNELACAVKVINWGYWNLGGGTRISAALKRLVEQRGVRPIEAREGLCALAVLLDGPLRQLAVTRTCQPAAIETFEAGQWLTVKAGTHSCFANVEAYQPTQPMPQESPDAARLNLWIVRLLFVQLQSLGLFQETGFQNATAIRRQAGIVDKYERWWRESLNILAEHGYLRLAGDEVARIASADEIGESSRERLWQEWRECKTRFLEQPQTHTLAVLVEDCLSQLPEVLRGTRLVTDILFPNGSMEKIEGLYKNNLICDYFNDVVAGVAQAYIQRRLENEPNAEIRLLEVGAGTGGTTSTVLPQLNLWRAFIAEYAYTDLSKSFFNHARLRYGTDYPYITYRLLNIEEPLIQQDIEIGTYDILIATNVLHATRNMRNTLRNAKAALRGNGILILNEISDKTIFASVLFGLIDGWSLAEDEHWRIPGSPGLFAENWQALLLQEGFDKVSFPAQVAHDLGQQIIVAQTNGVIHQHGAGPVLETAVADKPLPTLESAVAAERLVDRSSVPARRQDVAARVRELILDSLAQALSIGREQIEQDIPFSDYGIDSILGVGFVQRLNDELGLSLNTTLLFDYTTVQRLAEHIVAEYGHTLDVPAALPGPELSVSEPAMDIPLPAVQAVPSSLPRREAVVQTDGIAVIGMAGQFPGADSVDALWQNMVAGVNPVTELSELYLPYHAYSPEKQPGKSYCKWGGALQGRDCFDPLFFNISPREAESMNPHQRLILQESWKALEDAGYAPRSLSDSRTGIFVGAEPSAYVHESFVGASDAIVASRLSYFLDLKGPAFVVNTGCSSSGVALHLACESLRNGETEVALAGGVFAVMGQTILVGLAQTDMLSRTGCCCTFDADADGMVMSEGVGMVVLKRLDQALSDGDTIYGVIRASGINQDGASNGITAPSGIAQQQLITDVYRRYAIDPRRITYVEAHGTGTRLGDPVEANALVRAFRSFTESTGYCAVGSIKSHIGHTSSSSGVIGLISILLCLKHHQLPGMRHFKRLNPLIEFERSPFYVNARMMPWRSGSGEPLMAALNSFGHSGTNVHLVVEEFVRSNSEDPRVLDDVSSTAQPELILLSTKDAERLSEVLNNLAHFVRQAQNQPADLE

RLSLADLAYTLQTGREAMEQRVALLVGDLAGLLEALSALREERPCPVSVWSGRVEPGPSRGAETVNADQPAAELLQRIPQWLAEGALDELAQAWVAGAPIDWCQLRRRRPPRRVHLPSYPFARERYWRSEPAVHSPVVAAGLHPLVQRNTSTLDRHCFESSFDGSEFFFRDHRVQGQPLLPAVAYLEWARAAAQIALGNACPDVALKLSNVVWIGPLLAEQPIVGTITLQAREDRGIDYQISSVSAAGQQPVVHCQGIATTETEKEAAPVLDLDALRSRLTQKEIGVERCYAALEAAGVNHGPAMRGLQAVSRNAEEVLATLRLPAETVGEASAYVLHPAILDAALQASIALTLRDDEVEPSPETSPRPVLLPFALESLRVYAPCCASMWAWIRLVAVEHAGQALQRLDVDICTKEGEVCVALRGFTSRSLPPSGATESRASASAASSTLVSTEGVSRFKGEEFFLRDHSGMLPAAVYLEMVRAFAEGKHERKITGLSHVVWPKVLLVSGEGREVRTCLTNVDRSAFLISACEQSSEGPQEVTYCQGNLLLPEVMEEPGAALAIEAIAYRCPSVLEAKQCDRLLQSTHGPALMSVQQLRYSDREALALLQLPDELQMGWDDYGWHPSLLNGAILASVVWCLARAPRSRAGLPMPFSLDRLRVFQPFERQMQAYVRRHGSARSLGENLEKVDIDLLDSQGRCLASLEGFTLVFAPDANRLVYAIPQWVEQALPARVAASAPLAVQAPVFILAGAGEPLRRALHDSWPDALLHELPESAFEVGDGLRQAVVEVFGWCRRLLPYKGAALQPLLVLLPEAEREVTPQALLGGALSGLLKTVRLEHPRITARIISYPVDDTVTAGWMKVLAAEIASPEGDVEIRYDRQARRHIKVLHEITLSXGEHGDSLFRPDDVVWLTGGLGGIGRQIARYLGVERRVRLALSGRSAIDDKGERFLQELRREGAVVSYLRVDVADADAVGRALLAIEQEHGGLTGIIHSAGIIADDYLNSKTTAQFEQVLKPKVSGVVNLDAATANRSLRYLLVFSSIAGVLGNMGQADYAAANGFLDSFAHYREALVRQGLRSGKSLSLNWPLWREGGMQMGRHGEALMQQATGMLAMESAQGFEALEAGLRSAQAQILVAFGEPVSIRNRLLTFRMDAPEPPAPSVVEMDRAPGEEVGEQETQQLVRSVEAELIRIVAFVQRIPAEKINVRRDISAYGFDSISFTEFANALNKAYKLSLMPTLFFEIASLADLAGHLLTQHRPALLEKHAVDVEKPSECHSGVAAQIPIPTMPKSECIATLPLLPVGSIEPEPQADLEAVAVIGMAGKFPGCEDLEDFWTCLQSCQDLISEVPEQRWDWRRFYGDPHQEPGKTKIKWGGFVADADCFDARFFGISPVEAEVMDPQLRLFLETVWAALEDAGYPAGRLAGSRTGVFAGVATADYKDLLIEARARGLVQTPSEPFPFMIANRISYWFNFNGPSEAIDTACSSSLIAVHKAIESLRLGSCEMALAGGVNVLGSPRITIASSQAGMLSEDGRCMTFDERANGYVRSEGVAILLLKPLRKAIADNDRIHGLIRGSGENHGGRSASPTAPXGNAQKRLLVDIYSRADIDPRTISYIEAHGTGTVLGDPVEVNGLKAAFQELYQSRGLDVPEQPHCGLNSVKANVGHLEAAAGAVGIVKVLLMLKHRKIPGNPHLRRPNPYLQLEGTPFYLVRETLDWPQPTDVRGNPLARRAGVSSFGVGGSNAHVILEEYQEPERQGWGSEPAYPALIVLSAKDEERLVCVAQRLLRFIRDYGSELYLHDIAYTLQVGREAMPRRLALAVTSLAQLADRLQTWLEQPTQTEGVQQGLVTQEAEEQFDTVLGDEDRAAAVERWVEKGQYEKLLDAWTRGWAIDWNVLYCTDTRPRRIGLPTYPFARRRYWVASVPQAEDRGXSTLSEPEPEQRSAKSDLLTFEEYWAEVPLAAPATDRVKTLLCLCSDPEHQRRIAEQXDSRDPGVQLIFIEQGDAPAEPDEARQRIDPLQPSSYSRALTTIAKALGRVDALLYLWPCEDRRWISNVLPVLHLLQALYETGLRPRKLLLSGEYADALERCHLDSWVAFERSLGVVMPETQVAVVFRERAADTGESSPTWDWLEVLVAELFAEKLRSACYRQGVRHVPLIRPLAWQPGSASPFKQGGVYLITGGGGGLGMIVAEHLATVYAARLVLSGRSSSLAAEKYELLQARGAQVLYVGADVTDVHAMQEVVDQARRHFSPLNGVLHIAGLNGTAEVLKAEADAFQRVLDAKITGSQVLDQVLRRESLDFICYFCSSSAIIGDFGSCDYALGNRFQSAYALYRAQMVESSALSGKTLAINWPLWQDGGLGVGDAEQTRFYLQSSGQRSLCSQEALALLEQLLTQDRAQCLVWAGQPDRLLRWVNQEPLEAATVTVPEPVRAAKAVAERAELGGGLDLQQCLLRDLKTKICELLGTQYNELENHANLVDFGFDSISLAEFSRVLSRFYSLDISPSVFFSHSTLNRLTAYFLAEHRQTLEGFYQQPQPAGPEHAPVPTEVAQVSVPVPVTALLPTGTSIGSASQGQDEPIAIIGLSGRFPQARTIEELWRILEQGRDAIQEVPIDRFDWRSYYSPSQEMSKSNSKWGGCIPGIAEFDPLFFEISPLEAERMDPRQRHLMQEAWLALEDAGYGPEQLECNKISMFVGVEEGCDYQRRLTQQTSLTSMHNGILASRLAYFLNLKGPVMAINTACSSALVAVHQACQSLRHGECDTAIAAGVNLLVAPEAYVGMTQAGMLSPDGKCYVFDKRANGLVPGEAVAVVVLKRLSKALADGDPIKALIRGSGINYDGKTNGITAPSGASQTELLEGXYRQCALQPQDISYIVTHGTGTQLGDPIEINALYDVFKGKTDKQGFCALTSIKSNLGHTFAASGLVSLISLVLAIRHRTIPSSLHCEQKNDYIRWQESPFYVNTRKKHWECALGQPRIGAVSAFGMSGTNAHVVVQEHQPAEPSRWSTAAPYYLWVVSAKTETTLQEQIRQWEDYLSRHPDLDFEAVSYTLLKGRHHFKYRCAIVAKDLSQVLQALRQALDRQTQANLCMGCVDRDFSGQKAIRDFIASLAAQGEALRDKPDDYRDNLIALADFYCQGYEVADVHLFAGRPQRLSLPGYPFAREHYWIDEPSAAHRAELSERSFDTQLNPLLQRNLSTLSEQRYASAFKGDERFMLRIAHGQELLIPTLFYLEMARLAAQQSLDMPVRALKNMVWACPLYYQQGSDYELFLSLHEKDSDLLYTVEMQGEPVVCGHFGEIDSTEAALQLPVVPDIARLRASLPVVPDVALGAPEMGVARISDVQADATTLLATLNVPADGEDRSMWFHPLLINAGWWLLQQFVGDRAEGGP

LLPFSLKQITAPAAPPDQSLLLLRRHVRDVEQGLTCDMIFYNSKGETCLYLQELNVTTLDRLFDL PedH ACP KS10 DH KR ACP KS11 DH ACP KS12 KR ACP (KS13) ACP C A PCP TE MTFNTSNDQDAAAREFLEHELAKAVLDQFTETQSSPSVAQIIDVATNSVKNISPAADETLVKFKEEIAQIASTVLKIPAERLDVRENMSRYGVDSIVVTEIMRCISDHLDLPIAPTVFFEAGNFEELATILYQRYHKRIDERYQTQARAQERESAKVAPLHERGRAVQKNGELGVMEALGSDALAWIQRFRSVTSSEVARPQAQVRRVTKAARADGEILYEPIAIIAMDGVFPQSADLLEFERHLRQGDDCISEIPADRWDWREVYGDPKEGEFTRVKYGGFAPDIDKFDPLFFGMSPREAQLMDPQHRQFIQCVWRLIESAGYAPKALSGSKVGLFIGINLQDYAHLVDRADAMDALHLTSLGHMFCPNRLSFLLNLHGPSQVIDTACSSSSVALHRAVLSIQYEGCEMAIAGGANLLISPDMHIMYSKVGMICEDGRCKTFSKEANGYVRSDGIGAVLLKSLHRAEEDGDIILAVIRGSAENHGGMSTSLTAPNPKAQASLIVEAHRKAKVDPRSIGYIECHGTGTSLGDPIEINGLKLAFEQLYREAGHELPMRPSCGLGSVKSNIGHAETSAGIAGVIKTVLSLRNKRLYQSLHSADINPMIDLEQSPFFILQQGRDWQRPLIEGQEQPRRAGISSFGAGGSNAHIVIEEYLVPPLPEPVLQGPLIILLSAKNAARLDDMTRQLLHWLESTERVPSIVDIAYTLQVGREALSQRLALIVTDLVDLKTRLRSLLEGGEEPSGVYRGDTKANKAALQEIDDDDRSLEKLIAYFSQDDVHKLAKLWTQGVEVDWPSLYARMPFAGRSPRRVALPTYPFARQRHWIDKIAGSPQNRREAAATSPIVASRPAGYPLLQRTVADPAKRCYGCVLTGEEFFLTDHQVKGNKVLPGVAYLEMARAAVERISAHDARDKAPLYLKNVVWARPLMVNGATSLYISLAPEQDGRVAYRIYSEGEGESTEILHSQGSAILRGSESGSEVATARLDLDELRERITGGAPNAQRLESARCYEAFRAMGIDYGPAHRCLESVYFSAKEALPAPEVLAKLVLPAWAQEGAAAFVLHPGLIDSGLQACIGLIVGAGHELPTEAESEISGMTATLPFALDSLTLLAPPSDILWVWVRYADGSSTSDKVQKLDIDFCDVHGRVCIRLRGFSSRALEAEQAPDSATTVLCEPLWNERSVDSSAQVLWARHEVLLCDVQDDFDAVFEQNLGVTLGVPCSRLALDGPLENRYQKAALGVFEWIRQAIGDKIGGSLLLQIVIPATDRGCLLAGLSGLLKTANRENNRFRGQLIELELRETAEGVAAKLQADSRAAQDTHIRHRDSLREVRHWQVVPAGAVSTVLPWKDNGVYLITGGNGGLAWLFAEHIAQHAPHASLVMCGRSALTSERHQALEHLRGMGPRLDYRRVDVTQAAQVEALIRDLTTVYERIDGVLHCAGLLRDNFIQKKTPQEFAEVLAPKVAGTLHLDHATQALDLDFFILFSSAAGVWGSAGQTDYAAANGFLDAFASYRQALTAAGRRHGRTLSIDWPLWAEGGMRMEANAQIMMQRATGLTALPSAAGIEAFCRIMGSGATQMMVMHGAAVRIQRMLDESAEPLRAALPVRSATATEEPAARGRFDTQALKAGIEQLLLQRIAELMKFELEDLDVETQLTDYGFNSITLTDFSNRLNQQYSLEMTPTVFFEYPTVSEFAGWLSTEYPDVFAQALGLSIETPAEFRPEVRTDDGAREPSSVLSSVQAERMLGGIAMMASQAVSVDDAAVAIIGMSGRFPMAEDIQAFWSNLLEGKDCISEIPEDRWDWRAIYGDPTKEANKSDVKWGGFIDGVAHFDARFFGISPREAELMDPQQRLLMQYVWKAVEDAGYAPASLSGSRTAIFVGTASSGYGELMAQEGLAIESY SSTGVVGSVGPNRMSYFLNLHGPSEPVETACSSSLVAIHRALSAMAIGDCDQAIVGGVNLLISPQTHISFNKAGMLCSDGRCKTFFSKANGYVRGEGVGMLMLKKLKAAEQAGNHIYAVIRGSAENHGGRGSSLTAPNPKAQTQLIKAAYERAGIDPRSVSYIEAHGTGTELGDPIEINALKAAFKDLYQATGSVEVTAPHCALGAVKTNIGHLELAAGVAGVIKVLLQLKHKTLVKSLHCDEVNPYIQLQGSPFYLLSETQPWSTLRDAQGRELPRRAGISSFGFGGVNAHLVLEEYPQAEYIAESSMESLQASSTCVVPLSAKTPERLKVYASSLLDFITAPVAVSGPEGEGAHQLLTRWMQAMVAEILEIAVEEIELTQPLQEYGFDTVHGVILLARFRDAWGVDVGSAVLLGHQTSITSFVTTVLREQPSLRERLSGEPAAVAASPEPGHRVRRDIRLADLAYTLQVGRDAMAERLAMTADSMEELEHKLRAFVEGRSGEVKDLYQGSVKQNKRILSAFAGDEEMQEALDKWIQRGKLAKLLEIWVAGLNIDWQQLYGSDRSGTPPHRISAPGYPFAEQRHWIQTPSMSPAPVPVSAPVAAPEVLHPLVHESLCGPGLTRFKSRFEGTEFFLDDHRVKGRKVMPGVAYLEMAHAAAHLAQAIAPSSRVCLQDVAWISPLLVDQPQEVLIDIEPGQGERRSFSVYCMAGDGRRLHSQGGLLYVPQDSAQSRPCLELQALLAQSGMRLINADHCYERLAAGGLEYGPGHRGIHQLYAGNDQVLAHLVLPESLQATAGHYVLHPCLVDSALQASIGLVLTASETASGGREAPLMLPFAVQSVDVFASCESVTWAWLRHQAGIPVSGRVQKLDIDLCDERGKVCIQIKGFSSRVLAPEGGRSEAVTAHERREPLGVFAARATTPSPAPAPALSAVAEVDDDELSKRAIDYFKALLSSTLKFPVEEIAPDETMDAYGIDSIMVAELTSTLESHFGPLSKTLFFEYQTLGELVDYFLDAHRARLLQLCVTGGAGTSLAADAVLDSPPSTKPAVLVEHLPQPVPMAAASNTALDIAVIGISGRYPMANDLDEFWLNLREGKDCVSEVPSQRWNWRDHYSEEHSRAGGHFCKWGGFIDDIDKFDPLFFNISPSAAEYMDPQERLFLEHAWMAMEDAGYRREDLRKLARGSAAEDLPGQVGVYAGVMYSEYQLLGIEAARQ

GKGATVANFHASVANRVSYVLDLHGPSMTVDTMCSSSLTALHLACQDLKTGRTDMALAGGVNLSVHPNKYSVLSLNEFISSQGRCTSFGEGGDGYVPSEGVGVVLLKRLVDAERDRDHIHAVIKSSVLNHGGKTHGFSVPNPKAQQHLISRALREAEVDPRAITYVEAHGTGTPLGDPIEVTALSKAFAQYSLGGQPYWIGSVKSNIGHTESTAGIAGLSKVILQMREGQLAPSLHSQTLNPNIDFASSPFQVNRQLREWPRPVLDGRLQPRVASLSSFGAGGSNAHLVISEYIEPVERRAPDTTDSRPCLIVLSAKSEERLKAYAGKLCAFLESAGTRLELSLRNVAYTLQVGREAMQHRLAFSARSIEDARRILEAFAQGREVARLYRGYVKTARDSRSGRRDESVAEPIRGKDHDAVLALWVKGVDVNWQELYAAESDLPYRISLPTYPFARERYWLTLPEPPPPGGERRLPNAPIALAVLSDALLGSPAWKARAAEPAAVLGDYVERRLYVVGSSMEVPGIACVALDSDGQTVDQRITDYATQLFGDIKTLFQRKPKPKGEVLFQILLAQDTPMAGALAALLKTAAMENPQFFGQVLELGADILPDPSKLGALLDENAQDRRHPHIRYSRSGRQVPSWSVLSMASEGEAVWKQGGVYLVSGGVGGLGLIFAREIIRRVSDVTLILTGRSPLEGARAAAVQALRASGTNVEYRRVDVGDRHAVTDLIGEIERFCRDRGYGELNGVIHAAGVLRDNFILRKTHAQFSEVMAAKVAGVVNLDLATRSANLDFFVMFSSLAGVVGNPGQCDYSTANAFLDHYTVYRNQLVAKGGTSAPKGHTLSIDWPLWQEGGMDLAPEHKEELWRSAGIKPMRSEIGIAAFYACLQAGVEQALVLEGDLPRLRQLFFDDHSQPVVDEAAQGAETCTSEHSPDSLVRAVEGLLVRHLSELLKLPEHRIETDVPVEHYGIDSVGMMRLTVELEETFGSLSKTLFFEYQDVQSLAAYLAQTFPDQARALCGEPSAQAAPMEVPISSAPEPGSLPAGLVEAVVTAGEAAEWQMGERDIAIIGMSGRFPFAPDLEAFWENLSQGCDCITEIPPTRWKHQEYFDPEKGKPGKTYCKWGGFLESIDQFDPLFFKIPPAQAEVLDPQERLFLETVWNLLESSGYLGETLQRIAQSRVGVFVGSMSQQYHAFQADLTRESLVTMSSHSSIANRVSYFFDFQGPSVAVDTMCSSALVAVHMACESLLRXDCKAAVAGGVNLSIHPKKYIGLSASQILGSHPDSSSFGQGDGYLPSEGVGAVLLKPLREAVADNDTILGVIKSTTINHSGQSNGYFVPNGAAQTELMVSNFTKAGIDPRTLSYVESAANGSSLGDAIEINALTAGFGRYTADKQFCALGSVKSNIGHGEAASGIAQLIKVLLQLKHRQLVPTIKAQPLNSNIDFTHTPFCLQRRLEPWRRPSLALGDGPMREYPLRATVSSFGAGGSNAHLILEEFPLDRQESDNLEHERLPDSEEHLLVFSARTEAQLQAVVQQMLAELEKERSLSLADIAFTLQTGRKAMDFRLAVVVEGVEARLRAVESLRAYLRNETPGPTVFVDNVLEDHSRVREQLVGSAGQAILQRALMEPDLRALAGYWVKGIKLPWHQLHAGWKRKRVVLPTYPFERKSYWLGGNAGRVVLKASEHSERDAVEPEVERNGSASIERVIAQRLGSMLGMDEGEIEMGRSFQDYGVDSIASSELCRALEQTFKVQISSLELFSLSSLAELAELIAGRLPEQPLKKLKKLETPETVSVSSVSMPVSEGQKGLWLLHQRSPNMSAYNVPLVFCFKGELDVSLFRKACELMLERHPILGSVFRLTREDIQRIELREAHMGFEHVSVELHQRSEILERLRDYSKQPFDLEQGPLYRVYLLTSRTDNDAYVLICVHHIVFDGSSAMLLLKDLLATYRNLLHGGQPANIRPAAGYQSFVHWQRQLLNSEKGQTQLDYWKTQLSGEQPVLSLPYDFPRPAMPGFHGASEELTLSQALSSRLQALTKTLQVNPSVVFLGAFKLLLNRYSGYDDIRVGMPTSGRSLPAFQDQIGYFVNMLVIRSRVIGQQSVADFLKVLQLTVATALDNADCPFPVVLEALRGDGEPQSSSWFQVVFSYQNFIRDGDSAWLQADTQGTTAVELVSGINQEGGNDIALDVYHGGEQFLLKMAYDKDLFEAATIRRIMTHYVNLLESIATHPRGCIADQTLLSADERQKILGDWSNTGASLSMERQNIVQLFQRQVRSTPHKTALVFEQQSLTFAELDDQSSRLSLCLANYKVAPGDLVGACLGRGVRMVVALLAILKADAVYVPIAPDSPVQRICRLLVDSGISLLLSELELCNSFLSDLGTIECVCLAIDAPGWEPEEGELPVPPVIEGRQPAYVIYTSGSTGQPKGVIISHDSISHHCQVIRDYYRITAQDVILQFAPMNVDAALEQLLPGLISGATVVIRSEPLWSPDILCRKVVELGISVLDLPPSYLYELLLEIRDVAGWSRPPSLRLVISGGEALSPETLSLWCGCALSECRLVNAYGPTETTITSTVYEIESRARTFTRLPESVPIGRPLPGESAYILDTQRRPLPVGVPGELYIGGAGVAIGYLNRPELTASTFVENPFMAGTRLYKTGDAARWLADGNIALLGRLDQQVKIRGFRVECGEIEAALQALDVVKHVAVLAQPTQGSHRLVAFLELVQPALPEWKQHLKQALIKKLPEHMIPSVFVSLPRIPLSVSGKVDRNALKHLELANTESEVFVAPRTSMEIRLAEIWRRVLDIDRVGVHDSFFDLGGHSLLALRLMSAIKQGLGYELPISSLFQAPTLTAQAELLGQDAAVWSPLVCLQASGELSPWFCIHAAAGNVLCYRELAECLGIERPFYALQAPDAVGGGHPGSIVGLAALYVRAIRIFQPWGPYFLAGWSMGGVVAYEMAQQLLQAGEQVEVLALLESYTPEAIRSLERKALGLSAESDDRMDKLLRTFAVELGIGETPWELSAVDLAQGLEWILKRLEGSNLSTASFDLEQLHKLFRLYEANLNALDRYRLQPYSGRVVLIYADQTQQIDADEAQHLGGWQPWLRSGHCRSATIVGDHYSILQRPQVVQLAKVLTALVKDDGLATKYREVMVYS

Rhizoxin (Burkholderia rhizoxina)

RhiA ? GNAT KS1 ACP CY CY MVIFTDRLFFLSIILSLESRDLISRRGVCQPFELEQFALTASVNVGPLRVAFDGLKAFGWLGQSSGNEYF

FNRQACAVQALPDRIDEMFAWLAPKREPVKEDLTQLSCWLSLSALDWNLHCSALVHSLNDLLALAILRRL TLSDAIDHGTGQVDPRRIDSGRISPRLVHQVTDFLVARQWIQSSGEQGLTLNPTRRALLSELLSESFLAY CASLPSTLDDVLFGTRERWTTASRWLKEAGERQIWRGDQPALEQLLGTIFDVQPLATQPDWIIEFGRRPN SSLEDVWQWIRQHTARGKVLDSSPLRLLVLDDAVWGDLAALRRRLEDAGVGASERVLWLSVGQQNLEEPG TTPVSQSQLAPQRYYIRSNGLAADGASVLGGLQAQFNSLAALASSHFVVLSESHWRPSGALADRFAYHYG VEAAHYLMALAGAGLFANPGMLHKLPRDRADCDATMGCYQVREYRIRYATIDDLPALLRLEKACWPDGAR VDESILRRRLSQWSAGQLALELDGEVVGVIYSQRITKIDGLFGVNFATVDQLYHTEGSIVQVQSLNILPA HQSSGYGDQLLEFMLQYCTVLNGVDTVVGVTRCKDYPKHRHIPLGDYIHSRDERGILLDPVLRFHELHGA RIERLVAGYRPADHDNSGYGVLVHYDLASRQRQALQLTTAPMALPTVSIDDAVRQGVNRCLGQSEDSRLS SRHSLMELGLDSADLLALGEQLGPMFGLTLEPTFFFRHNSIDKIVAALKERLDGQAPSSSGSNVLTPPST TTSPQKPPSPSIEDHDDFAIIGISGCFPGGELEDFWAAVRSGASQIREAPAGRANAGSVGGYIDDIDCFD HPFFGVSAAEAALMDPQQRLLLQHAWLALEDAGIPAAQLARRPTGVFIAAAPSEYRSVVEVPKDSPFLLT SSSACMYANRVSYLLDLRGPSEYCNTACSSALVALHRAMQAIKAGECRQALVGAVNLLLSPDETAGYQLM GFLSAHGQTRSFQAGADGYVRSEGVGVLLLKPLADAEQDGDHIYLKLKGSGVCHGGRGASLTAPNQDSMK AAIVAAYRRANVEPNSVSYVEAHGVGSLLGDAIEIAAIQAARAELSDDDHDGPWTISTLKPVIGHCELAF GMAALFKVIDAVAQRQLPGIPGYAQLNPAITLDQRQLRLQADSRPWPAPKDANGLALPRRASINSYGFGG VNAHLVVEEYIAPQRAIQEDVGPQLILLSAHDAARLTEQAARLSRYIAQRPDLCLADIAYTLQVGRTAMA CRWTGVVDSIVSLQQQLDALNRAPMSEITMLDADTMAIDPLQAGISDEVDLAFTRCDLQALAGYWRQGVE LDWLKLPRLGEARRISLPGYAFAKTRHWLPPRQAAVACQTSEGVAQPQGFRQILAGLLGCEPAALDGCES RSLASLGLNSLAAVGLKAKLEQQLQLSVSLAQLSPYLSLGEVETRLAALAGQGDNNHPVPRLQTAPNDQW QPFALNDIQQSFLSGRKLLAETERVGCHIYLEFDWPDLEVYRLNQAWNRLMSRHEMLRVKLLDDGRQQIE ASASYRIKARDLRRIDTAGRELALAAIRASMSHNVYLPGQAPLFEIRVSLLDQQRSRVHLSIDELVVDAT SLDLLLQQWLMLYRDPAAQLPDHGLSFRDYQLSLEAFKQSPRYQRDLQYWVDKLAQMPPGLCLPKAQRPA GRQRRRLASMLEPSRWLRLKQQSDALQISGTALLLTLFGLILRQANAGKAFSLISTFYNRVPLHPAIDHV IGPFISNHFFAFVDAGEETLAALAQRVQRQLLEDIDHMSVSGVAALRETRRRCGKSLHFSGGEVVFTSML NNPVIGGADSFGDAQHYCVTQTPQINLDHQLRECGGALSFSWDVAIDCYPDGMIDQLFSDYCHLLHKLAD GEVDWQAVNTGELVGRLMAAKQPLPVSTAGHTGSFMLAPSEPPKTPFALTDQQQAYAFSRSLYPKQSSSH LYMAVAIEDLEMSRLEQAWRQLVAHHPMLRTRILPSGTQQLMEAVPPLQLELSEQGVDVDQIADEMLGRV TALGDWPYAELRVSQLDGRCSLVHLAVDLLIADLPSRDLLIRQLLDLYHGRPPAPLSINFGGYIKALGQY RRSPAAQNAAAYWQEKFRLLPQGPRVSDKDAKGQYLGYEHRLDCWPALRHRIAQAGICADALLISAYAWS IAEHSSKQAFTLVAPGWHRPAVHPEINALVGDFTTLSWIDFNDEPMTFIERVRRCERIFTEDERHGAISG LQALRKVATDKQQPRKLNFPVVFTRLNPQGPLDLPDGTRLTKSASRTHGVALDNLSIEHQDALLIHWDLA AGCLAPAQVEAMFADYCRLLEALADDDSLWTVQEPQLAATLAADKYPVMS RhiB A PCP OX (KS2) ACP KS3 DH KR MT ACP KS4 DH KR ACP KS5 DH KR MERSVELIIALLAIMKAGGAYLPLDPGYPDERLALIIDDAAVTVLLTQQRFRSRLAGYDGEVLCLDDANQ QALFGDEANPVPINGPDDLAYIIYTSGSTGRPKGCMLPHKAICNRLLWMQRHYEVGAADRILQKTPFTFD VSVWELFLPLLSGACLVMAKPEGHKDAHYLVEVIQAEQITICHFVPSMLRFFLKHPAVSECISLQKVFVS GEALTHDLLLQFRQLLSAELHNLYGPTEAAVDVTYWRGEPREDQLVPIGRPIDNIQIYILDSEAKPVPIG ETGELCIGGLGLARGYLNRPELTAEKFIRDPFSGEAGARLYRTGDKARFLSNGEIELLGRFDSQVKLRGF RIELGEIESALKSHPAIDDAAVLVKDPGSADPKLVAFVVAQGLDKKAVRDFIKARLPEYMVPNLVSFIDQ IPVTAHGKADRKALLTGDVEATAQPRRQAINSQSLTAWLQQYFIEALGIDELAADDDLFDQGATSFTLVQ AVHSIQQQHQVTLPVDVFLEHPTIAAVTAYILEAKGITADEVEPPPLSAAPACQSTDRGSVPLEKVSFDP RAYWRPTKGSFANLERLGRLLSLLREVPLDGQGKYLYSSAGGLNAIQCYLYVAEERIDGLAGGVYYYQPQ LNRLLPVSVPAQLDAQALPPAQRAQLAEAGFALFLIAENDAIAPIYNKASPFLLVLEAGYIEQLLLSRQR DFDIALTPAYGVDFAAIAGLFKLRPSHRFLHCLIEGVAPAAVAVEGQALNDHWRQSGPLFADFLSEKNNG FALPTREELAQLHEEQRQIRHDLPEQGDGVIELCAEPISADALRLRAAKRQYCDGPLNLGQLSRLLNLLR ADQVNGQLYHTDAGLALKVYLHVAEQSVQQGCQGPWLPAGVYRYQGDSHSLVRISDGDLAAINSCYTPFN RKHAHQARLRIFIIAGHSTTYGDESRYFNLLQAGRIGQLLLEKQGEFGIGLCPIGSMYFNKIRDAFDLDD GDELVHSFVGGAVTQPLPAGWPRLEMHGTDESAQVAHASAHEINEHVSSRAVKAHCNGDAMAIIGISGRY PGAANPDELWQNLSAGRASIIPLSREALFYGSDDAGDSPQWAVGALAGKQLFDPLLFKITPAEAKTLDPQ ERLFLQAVWHCLESSGYTAASLRRQAERIGVFVGAMWGDYQHHRPTEQGERATSFLSAIANRVSFFNDFN GPSVAFDTSCSSAMTALHFACNSIRQGECQAAIVGGVNLISHPSHLELLTSLKLLSDDSQSYPFGRHANG WVAGEGVGALLIRPLEDAMRDGDSILGVIRATAISHSGKTFRYGAPNADSHALSMRRVLQQAGLSADEIG YVEAAAPGASLADGAEFAAISNVFGARRSDAPLLVGSIKANIGHLESASALSQITKVLMQLKHRQIAPTL GCNPLSPMICLDDNHLAIADQLSDWRGPQRALINAFGASGSGGHLIVEAPPQQAAVRQSDGPWLFPFAAA SSEQLDQLVAAFADDMQAGRFNDVSLGDISYTLCVGRVALNHRLAVVADSRDELVARLQGQHSQMPLRGS LKKEPQPSRIEKDLQGLDRQALTAIAGQWVAGQSSLAQIARHHHRRVALTAYPFAAVDCHIAASANSDCA DVLQNEASRPGNEASQLGNDTSQPEQDEVLRQALENHIKRHFSKVSAIPEHNLDCEDTFDRYGLTSLMIT TLNQRLAQEFGELSATLFFEYQSIAALAGYFVAEHPLRSRQLLGIQATQPVLAARVQQQPHVTAVRRYDR GERNEPIAIIGLAGRFPGAADIDSFWNNLKNGVDSISEIPAERWEHSKYYSRDRSVKGKIHTKWGGFIDD IDRFDPLFFNISPRDAERMDPQERIFLETAWRTLEDAGYDRAGLRRHYQGEMGVFVGVMHGEYLLYTRSS APDCTEDAVDSSFGSIANRVSYVFDCNGPSMAVDTICSSSLTALHLAVESLRRGECQLALAGGVNLSLHP NKYFIQSQLTMSSSDGRCRSFGDGGDGFVPGEGVGAVLLKPLSRAEADGDNIYAVIRATSINHNGKTHGY

TVPSPNAQGAMIADSLDKAGMDPRELSYIEAHGTGTALGDPIEITGLQLGFTRRSATLGSAMASAQQCAV GSVKSNIGHLESAAGIAGIAKVLLQLKHRQLAPSLHSKRLNPNIPFADSPFYIPQQLQEWRRPVLNLDGR EREYPRAASVSSFGSGGSNGHVIIAEYIAPTRDDDVGGQTAMIPLSARTPAQLRQQVEQLHQFLHRTGAE LTLPRLADLAFTLQQGREPMEYRLAFIAESIDQLQDKLAQSAELLANQPEPFGFFDGIHIGRVKDHKAAI AVLAHDDDMAATLTAWANKRKYDKLLELWVKGLALDWTLFGQPKEAAKRISLPSYPFARERIWVSGESHF PSLGQQSGGGRVHPLLHTNVSDLSQQKFISIFDGREFFLRDHLIRDHKVLPGVAYLEMAREAIIRSLGEQ VPTGVLSLRNLVWSQPVMLSQQSDDSVEVEIRIDSPDEHRLTFDILERKQQAVCCQGEAAFVQDADEPAE SLTSLQAAIGGHMLDADALYRLFDSMQIYYGPWHRSVKALRIDGGQVLAQIELPQALTSEHERLVLHPSL MDGALQATVGLLVADQLDQGLTPQLTHTWVPFALTQLQLSGAELGHQIWAWVRPCTEQTEAGQSTFNIDI YNQQGQHCAALREFALRVMKKPSPLEVMLEDRPQSDCYLVEKWQRFCPQDLVPSTGRLLLISNDPQGHKQ LIARYPQAGSLLLDGHESIEQLTERLREVGPIEHLIWLAPATLAQQENLDGMIRAQQHGVLSCFRLIKAL LALALDQQPLTWTVMTRGVLTVSNEADSHSQAVTGPVAPAHASVHGLIGVMAKEYSHWRVRLVDLPVGDG WPTVDPLSLPTHPRGDALVCRDDVWYRQYLAPYLPLSKWDATDAAAQLGDVDSLYRDEGVYLVIGGAGGI GRLWSEYLIRTRRAQIIWLGRREQNSDIDQAIAELAKLGPAPRYLRADASNHAALRQAVAQVYTEYGRIH GVVHAAIQLQDQSLARMDEQRFTTGLAAKVDVCVRLAEMFAHQPLDFMLFFSSLQSFTKSAGQSNYAAGC TFKNAFGHYLAQQCSYPVKVINWGYWGHVGSVASEDYRRRMAEVGLGSIEGEQAMAALDMLLAGPLSQLT FLRTSQRLSDTFSHLALPTHPAGPFGEYGQRLTQAYPSLIARIKKHLVVDNHAIRTVTQQMQARKAAIDA LQGRLLYAQLQQLGWFSSEHEIIEQMKQRSGLLPMYERWIDKSLDELAQRGYLSMEGGHCPTAYRVAHPQ PLAVESLWNEWEAQKPDWLEHASLKAEVILAEATLRVLPAILNGRIMATDIMFPDSSMAMVEGIYKHNPV SDFFNEVMLNAMVEFVRARLEQAPQTPIRILEIGAGTGGTSARAFEKLRPYQRQIAEYCYTDVSQAFLMH ARQTYGPDNPYLSYQLFNVDRPLAEQGIKIGHYDLVMATNVLHATQDLRRTMKNAKAALKHNGLVMINEI CRNGLFTHLTFGLLKGWWLFDDQDLRLPGGPALAPKQWKQVLESEGYRQVYYPALADHDLGQQIVIAESN GVIWQDRHSDVEPTKVAPKRLAVQAAPASRPPQRSVNTVSVGEVTPQALKDQTVHYLKQMIGGLFKIRPE QIDAGEPLETYGIDSILVVQLTNLLRDKLSGISSTLFFEYQTIDALADHFVESQKDQLRALLGLDKASVV EQPASVDTASTHAANTLVKLAAGHRFAAKTPDSAPKGQGGTDVAIIGLAGRYAHSDNVQALWQRLKNGEN CIDEVPADRWDWRQYFDQTPGKKGSIYTRWGGFIRDIDKFDPLFFHISPHEAQKMDPQERLFLEEAYHCI SDAGYTPGRLSERHRVGVFVGVMNGTYTHQSSYWSIANRVSYQFNFQGPSMAVDTACSSSITAIHLALES LHSGVSDCALVGGVNLVIDPVHYMRLTEMKMLSSGKQCKAFGTDADGFVAGEGVGALLLKPLAQAEVDGD RIYGVIKGSMINAGGKTNGYTVPNPLAQSRLVADSLARAGVEARAVSYVEAHGTGTSLGDPIEIAGLTRA FNSGAETAAKQYCAIGSIKSNIGHCESAAGIAGITKVLLQLKHRQLAPSLHADELNPEIDFANTPFIVQQ SLADWHRPEVMINGSRQAFKRIATVSSFGAGGANAHVVIEEYEDHRPRPVIVVNEQQPAIIPLSAKTQAQ LLQQVSLLLHALEQDELGDADLPALAYTLQVGREAMEYRLGWLARSLAHLKTQLQDFIDHPSTAACYSGR VKDHEKALSLLAGADRQSTIANWIDRGQPEKLLEAWVNGLTLDWRLMYRQGTPTPISLPGYPFARERYWH NDEPAQALATSEARLHPLLHRNVSDLRGLRYLSRFSGQESFLSGHRINGRGVLPGAAMIGMIDAALTDAL GDERPAGTARVIRDLFWYQPFSVEATNHGELFVELAAQPDGECQIGICSYDFAGQLQLHCRAVAGTAVAQ PAKLDFMTGDARPMDVDACYQRFTAMGIEYGISHRRIQSLLRHGDQALAWVALEDAAVSDGYAIHPGLLD AAMQAVMALLFDELGERPPLLLPEGLAEWVLFDDCPTTLQVQIRRAGRTPGGYRFDLALFDKNGRCCATI RQLSFKTLSADNDVTSETLLCHRQWREAALASATDAPVTSQLVLTLGHHPAFASLPEQLQAHPSISSLVM HSDDYRQAALALVEQLKPLLRTERRCMVQLVIPANDQHGYRGLGGLLYSASREQPALIGQLIEVSPGLDA SQLAGQLAAERAAPGERQLRYLLDAGKLRRQELTWHHRPLSHSPAPWRPDGVYLITGGLGGVGMIVARAI LDAAPGASVVLCGRTEANAPSVADKLAQLGARCHYRAVDLAQAGQVERLIAAIMMEHGGLHGIIHCAGLT RDTLLAYKTQQDFEDVFAAKVAGVRHLDQCSAAVALDFFVLCSSIASVLGNAGQSDYAAANGYLDAFAGL RNQRVAAGQRHGRTVAINWPLWLEGGMQMDDAARRALAQRTGIKAMTGTTGIRALYQALQSDEDQLMVLA GDKDKLVALLSREPAPVSPAITAVDGDDVLMGLRRLLADTIKIDESRLDNDEPFEKYGIDSLMVMDMTAA LEKRFGPLPKTLFFEYPSLQSLADHLVARLPQKPAVSQVASAACGSLNAQLRAMLASTLGIALEQIDDAQ CFEQYGLDSLKIMEMTSVLEKRFGALPRTLLFEHSSLQQLAHYLANRPLEPQGTTAVIPTDEQKPLATPE SGGKVSQSRRLFDSVANTISPRVQPRLQDSQLGPQRRDDIAIIGVAGRYPEAENLEAFWQNLRGGKNSIT EIPAERWNWREYYSENRRESGVHNSKWGGFIDGVDQFDPLFFNISPLEAELIDPQERLFLQTAWSAMEDA GYSRRIGGEQTEDSAQVGVYVGVMYGEYQLFGAEASLRGQRMGFAGCTASIANRTSFCLNLQGPSMTVDS MCSSSLTAIHLACQDLRNGRTSMAIAGGVNLTIHPNKYLMLSSGQFISNQGHCASFGEGGDGYVPGEGVG AVILKRLADAQRDGDHIYGVIKGSYLNHGGKSTGYSVPNPRAQQAAISGALQDAGVDPAIVSYIEAHGTG TKLGDPIEIAGLANALGTRKPEQTCWLGSVKSNIGHCEAAAGIAGLTKVLLQLKHRQIAPSLHSQKLNPF IDFAATPFEVNQQLRAWPQPLLNGQAVPRIAGISSFGAGGSNGHLIVAEYCQAKPVLDDSGKPEMILLSA REPEQLRQIASRLLARLEHLQAADSLAAIAYTLQVGREAMEHRAAFITSGMASLLDALRRLSDGDSRGWI CGDASTTSERVEQFKARFQGQWREQLVRLFKDGEQQPLLQLWSEGLSIDWAALWTASGEQRQRISLPSYP FATRRYWAPTGARPVSSSTPMQLHPLVHQNSSRFEQQQFVTEFSGDEPWLKDHKVSGRKTLPGVAYLEMI RVAVMHSLAHGKADAMVIEQLHWLAPLTVESNPRRMQISLARVDERIRVKWFTNEGDLSVLHGQATAITG LSLHEEPLDLAYWQGLNWRLRLDSDEVYRLFSEMGIDYGDSHRGIRQLMVAQRGSRRDVLAQLELDGALP GTADDWWLNLGITDSALQAAIGMLLPLDGSVADRASPLMPFALERVEILAPCRQRMWALLHRDDADNAAG KIDIDLCDDQGQICVRFLGLSSRQLPAESKPPSVALERVDPLVPQQQEARHLLAPIWSVINGAVAERRQQ QGAVLIFGATPARRQALAKLYPGAALAPNTDDSEAGYQAALNTQSKFAEVIWLAPASDDHCASASELVAA QQHGVLALFRLIKVLLSLGYGRQPLRLTLVTEQAINTLPGESCRPAHAAVHGLAGSLAKEYPHWRVQLAD LPNEQLASLANAPFDHAASGELLALRHDQWWFRKLARVTVDAPPATQQPAYRNGGVYLVIGGAGGIGTVW SHHVISHHRARVIWIGRRSPDQQLKAKLDELTAVSLRHNAPAPVYFQADAANEQQLAEVRRHIIERFGEI

NGVVHSAIVLKDQSLANMDEQTFTRVLNAKVATSVALARAFEPSAASLDFVLFFSSMMSFSTAAGQSNYA AGCTFADAFADRLRADWPCPVKVINWGYWGSVGSVSDVRYRDRMSALGLGSIEPQEGMLVLEQLLGGVMN QLALLKTLQSEEIDGLDSLAGLLSHEQIKLYPDDHGSMAVMRNRLTDRLAALAPPLGASQPISGVSGTLE CV RhiC MT ACP KS6 KR MT ACP KS7 KR ACP KS8 KR MT ACP ACP MLTDANQTTATLAGELEALACRLLANQLHRLGLHRSEDLRRLASQHGNATPDYFYLWLAESLKYVAGVDV GDPDALWQQWHERLANWRQDSDLAARAQLLDACLKDLPSILTGEKPATSVIFPGGSMALVEGVYKHNKIS DYFNRVLIEAALAYVESRPKDAESVRILEIGAGTGGTTAGLLAALAPWRAHIDEYCYTDLSHAFLQHGAH EFGRDNPFLQTRLFDVSRPCMEQGIATDHYHLVVATNVLHATPEIRQTLRNAKAALRKGGLLLLNEISEA SLFTHLSFGLLEGWWLYQDGALRIPGCPGLSPAGWQAVLEQEGLSPVLFPAQQAHGLGQQIIVAQSDGIV RQPIAKVERPSARPSIASQRDDDSNPTQDGIASGSWRRRVSDYLRKLVASTLKIPADKMSLSRPLEDYGL DSILVVRLTNAFNEQFEAIDSALFFEMPTLAALTEYFIQHRQDELKALLGQPKVEPNKGAAAVDQQGSQA NAQPALEVNGTPEIDHVPATVELAGRDGKNKIAIIGLDGRYPGAESMTAFWRNLAGGHCAIDEIPADRWD WRRYFDPEKGKAGHLYTRWGGFLKGVDQFDPAFFRISRREAERMDPQERLFLEVAYHSIEDAGYNPATLY QQGEVGVFVGVMNGSYNPISNYWSIANRVSYQLNLQGPSFVVDSACSSSLTAIHLALESLANGSCEMAIA GGINLIVNPHHYLNLCEMMMLSPGERCSAFGDDADGFVDSEGVGAVVLKPLDKAVADGDPIYGVIRGSAI NAGGKTNGYTVPSAGAQQRVLEKALSRSAIDASRISYIEAHGTGTALGDPIEISGLSRAFDNCNGVASQG CAIGSVKSNIGHCESAAGIAGLSKVLLQFKHRQLVPSLHAEQLNPKIHFEGTPFRVQRQLTPWPANGDTR IAAISSFGAGGANASLIVEEYIGAVDQRPAAAGPWLILLSARDQQRLAESVSRLQAYLDSEDGHQVQIAD LAYTLQVGREAMDVRLALIVDTLPDLRRRLTRWLNGEPIDDAFHGHVDPFDEALEAQRSDAESQKQIGRW LEQRELAELAALWVRGGVIDWHRLYLDRAYRQPMRVNLPGYPFAKNRYWMPSLAHPTPCHGEADVQQAES LPLLDREVLADSDLSHCCYLPRWQPQAAAERAMLAGPGAIVLVAAEQRGAATGLLLAALADHYRDSRTVV QIDCGTGATTELAAGRWRCGDEDPQGFARILAAVGKVAQMIVIGAEAKRDVTPLMLADSVQHNELPLLRL FKALQHHLAASAWIDCFLLSLDRYPFAGEQRVGNPLGAGMAGLGYAMAQSDHRVQLRNLDICSVELDTLE GRQRLLAQIFAEPASERGELVKFSRGERFVQQLTPLALPVSGNSRSALKRQGVYVILGGSGVIGQVISRQ LIEHYQASVIWLGRKAADSREVQQSVTAVSFHGRVDYIQADATDLSQLQQAVAQIKQRYGRINGAIFSGM VFDFENSIQQTSEAQFRQILEIKSRGSIHFYQAFAEQPLDFLCYFSSGQGFAFSGAAKLSAYACGITFAD AFADAIRPAAAFPVGVINWGFWRASLQPQAISQHMDALDDDEGFACFSRFVANLAGGSLPRLLCIKASTA VRQLMAVPQGRQYKLDPLAVPAPPAQSVELEPAELARLQHIFDPRMLDQSIAVLLLIQLQTLGIFTAPGQ QSAEAWRQQAGISDRYRRWWQECLAILVEHGYLQQQGEAFGLAVHIAQERHAAIWAAWREQRDRYLEDRD RRVQVALIDDCLQQLPHILIGQIQPTDLLFPDGSMAKVEGIYKQNTLSDFFNDQLAAVVTDEVRRRVEVE PQRPVRILEIGAGTGGSTARLLPALQPLAGQIGEYCYTDISRAFLQHGQSCFAADYPYFTTRILDISQAF DDSNPAAVGYDIVIATNVLHATANMRRTLAHAKAMLRGGGLLALNELNRKTTAATVTFGLLDGWWLYEDE SLRIPGSPLLADDSWTALLCSEGFKQVSLRINHGVTLGQQIITAHSDGLVLQDIGQSSPATSARQPENND SMLNEHPTSKAGQCEDMAGKLQQLIIDSLAKTLKADAQSIALRTPFSDYGVDSILGVGFVKHLSQQLGIK LNSAILFEQATVAKLRDYLQNTYGEQIKQALAEPIDARPAAAVANDTSKTPPPAIAAAAATMSPVMAVAL GGAGRPTAIDAAPSDQSLVSPAASGRIAVIGMSGQFPGADHVDELWDNLLAGHNSVQELPQHYLDPRAYS ADKQPGKSYCKWAGILKNRDCFDPLFFNLTPHEAESMTPHQRLVMQESWKALEDAGYNPMTLAGRAVSVY VGAEPGGYHHDSFTGGSEAIVASRLSYFLDLKGPAMVVNTGCSSSAVAIHQACESLRHAESNMALAGGVY ALLDQRGLISLSAIDMLSPSGQCHAFDAAADGTVISEGVGMVVLKRLEDAEADGDPIYGVIEASAVNQDG SSNGITAPNGDAQEQLIRDTYRKFAIDPSQISYVEAHGTGTRLGDPVEANALIRAFRQFTDARGYCVLGS AKANLGHAAAGAGVIGLIKILLSMRHRKLPAMPGFERLNPLIELEGSPFYINHQAIDWQPTGGKRLLSAL NAFGHSGTNAHLVIGEYQARQVVDLCPAPPTVSRIFPLSAKTAESLQDNARALARWLDNSASSQPGLLAN MAFTLQTAREPMRVRAAVVTDNFSDLQAQLARLANGDSPVLSADEAGQLATEWVGGAEIDWATRWPAGSA KRLNLPSYQFAKERYWVDQTAQSAIAAHSAIEAPNATSESTGDDLPQSATGLFLARPVWQEPVGGNAHAH DGAGQRLLFLVGFSSEQVAQWQSLSAAAAGALSCEVLASNKRTPAARYQELAIALLLRLQKLSGRVHIEL AIAEHESDSLLYAGLDGLLKTACLEQPTLSARCLLVEVEASQPLPALQLNELTAMLSETHRSGSSVLQRS GADGGRLELQWQELADDVAAGQPIHRHGATAGWKDRGVYLITGGAGGLGLIFAKAIAEQCREATVILIGR SALDHQQQARLQQVRDAGAQVSYHRVDLTDAQALEQLMDEICAKHGGLNGVLHSAGVNRDRLLARKSPQD IAEVFAAKVIGTELLDRACRRLYLDFFVLFSSCSAVLGSVGQADYAAANAFMDHFASLRNRRVEQGQRFG HTMSINYPLWRDGGMQISAADRADIRRKTGMAPMQSVHGVNALQLGLNAALERLLIIEGDLSQIRGHFTA ASGAEELAAVLAAAGSGVQDPVTLADAAVDRERLIATTLERLKAVFCEVTKLPPARVESDALLEQYGIDS IMITRLNKALEDAFSRMTSLQPAERQLSKTLFFEYHSLDKLTGYLVERHHRACLLWSGLVEVESGGRVPS QALSQGEAGVAKLETTVAERRVTAAEPVVAAAVEPIAVIGMSGRYPQADNLDEYWRNLKEGRDCISEIPA NRWPLQDFYVDSVQQALKQGRSYSKWGGFVEGFADFDPLFFNISPREAVNMDPQERLFLQSCWQALEDAG ITKADLVEHYQGNVGVFAGITKTGYGLYGPALREQGHLIFPRTSFSSTANRVSYVLGLNGPSEPVDTMCS SSLTALHRACESLRRGECRMAFAGGVNLYLHPSNYVELCAGQMLSKDGCCRSFGEGGNGFVPGEGVGVLL LKPLSQALADRDNIHAIIRATAVNHGGKTNGYTVPNPQAQAKVIRLAIEQAGLHASQISYIEAHGTGTEL GDPIEVSGLSQAFAMDGVDLGRCALGSVKSNIGHLEGAAGIAGVSKVILQLKHKQIAPSLHAAKLNPNLT LDTTPFYLQQALGDWQPAAEGPRIAGVSSFGAGGANAHVLLQEYNEYRELPNHRGAEVILLSARDGERLH DYAKALLTYIEARPSMSEADLANLAYTLQTGREMMATRLGLVAETPVALAMKLRAFIDSGGQAGDGIYVG DVKRERLATQADDDWAPVIRRWAANGKFDKLLQLWVDGEVIDWSLLHAERPGPRPYRISVPVYPFARETF WLPHSEPSARAPIASDERAVAKVTPVPAQPASAIETVAASVASTVCDRLSYVARWQADGRHDQPLISEHR

CVLIVADASAAVAAEAIASQYLASADFVDGGGKVIRLEPGQLNRLVGTDHWLLDVADPQALDCCLGGYPA IDCFYFIGGSGEATDWQALLDSPRYNEIVLLRLIKWLKQHGGRQTIDSYIISQNNFGMAGEPVNAFGGGL TGMAYAIAQGEHRFRVRHLDVDSRERADSRSLPQWVRQLQSERGLARGDVLCLRAGQRYRRRIFSLAWQA QQPVRANTDFVTPALKRGGVYVILGGSGTVGGIISRYLLADYQANVIWLGRSGADDPKVRRRLDRCLSSV GSAVDPAQLAYLQADANDLASLQRAVAQIKQRHSTINGAIFSGVVFNHEEALTRMPEAQFHEILDVKSRG GIEFYRAFANEPLDFMCYFSSGQSFAFSGAAKLGAYAAGITFCDSLVRSLRHHAAFPVGAINWGFWLSSL TEQQAVDPSAQPMSRHAGALEDRDGFECFARFVQALSRGQLDHVICMAASAPVQQLMQLQPEPIVLADGG DHKPIDGFERYRVAAAPLLAAHDPMPFDEAMAGMTFVQLCRMGLFGQPGCFEDSEVMRRQAGIGDHYRRW WSTCIDLLQQHGLVLRRGTQICANDKASSQQQRLAERWHQLSGELRASAQRKAQVELVDACLQQLPAILS GRVQATDVIFPKSSMEKVEGVYRNNALSDYFNQVVAGVVQQHIEALLAKDPQCRIRILEIGAGTGGTTSI VLPALQPWREHIAEYCYTDMSKAFLMYAKKTYGPAHPFLTYQLWNVEQSPESQGLTLGHYDIVIAANVLH ATGRIHRTLSHANAVLRRGGILVMNEISDRSLFSHLTFGLLKGWWLYEDPELRIPGTPALYPTSWASVLG ETGFCDVAFPAQCAHCLGQQIIVAQSEGHACAAPADRPTQAYRSPGLQASDVQERSAGVVGNGDSRDALT AVALNGLAKTLQLEPERIMTDQPFADYGIDSILGVSFVGDLGEALGIELNTALLFDYPTLDSLVDYLLGQ YPAESARLAGGQRGDVESANGLGSAHTPEPVSAHTPELVLAPTLDPVVTAQVNGASQEAAAALVVQGLAS ALQLDAAQIDNEQPFSDYGLDSILGASLVDHLNEALGIELSAAILFDYPTVTTLSTYLVDHHRAELATWL NGVHQAGSAARGAPKPYRQFEPPHPLDHQLEKQFLSGELSIDSLLNLVSIGTVER RhiD KS9 DH KR ACP KS10 DH KR MT ACP (KS11) MSSQEFQSIIAGLQNRQITVAEAKQRLQRLKAASATLGTEQTEAADKAVSGTGRAQEPVEIAVIGMAGQF PAADNVERFWRNLSTGVDGIVELGERYLDARRSYSSQRQPGKTYCKWGGVLEQRDDFDPLFFNISPRDAE SMNPHQRLILQESWKALEDAGYNPKSFRNQAVGIFVGAEPTGYFHETFIGASDAIIASRLSYFLDFKGPA LVVNTGCSSSAVAIHLACENLRNRETDLALAGGVFATLGEPSLISLSQMDMLSPTGRCHTFDSRSDGIVL SEAVGMVTLKRLPEAIADGDPIYGVICASGMNQDGASNGITAPSGQAQERLISELYRRFGIDPRQISYVE AHGTGTPLGDPVEVNALARAFRQFTADTGYCTLGSAKAHIGHTSAAAGVVSLIKILLSMKYRQLPGLLNF EQLNPRIALADSAFTIHRELKDWPVGDSGLRMAALNSFGHSGTNVHIVVREAVEVAAATCAEVSRPRLLP LSARTADSLKHYACRVREALADPAVRLADLAYTLQTGRLAQDHRLIFLCTDKAQLTQQLNDWLDGRASEH AWHGQIGTGEHSAIELPSTDDHADLQRLAKAWVAGGHIDWNAFNRRYNADARRIHAPVYPFARQDFWIPP ARRGTAGGDVGAAPSLSVGRLHPFLTQNTSDLLSQRFTTVFDGEEFFLKQHVVGGKQIFPGVGHLEMARA AVAMAANGLAGTAQQPVLSDVVWLRPLIIDGQARQIDVALTLEEDNQIRFEITSRDYDPPSGLVSGEPVL HSQGLASFVEPAAQRQVDLAALKARMDGGQLSAEQCYQAYRAMTFEHGPAYQGLQSVALGRAEVLAELAL PSCQHDSLNDYLLHPSLMDSALQAAIALSIGADVVLPEGDRGSLPPATRPALPFALEGLQIWDRCSERMW ARVAYAERRDDQQADTSLQRLNIELFNQQGKLCVLMQGFTSRVLGDHSDQATTEPALTETVLFQPQWIDE AARHRKTADFNQQFVLLSGFDEPCVADVQRQLAEQGTDCRCELLAVPQQDPAEDYQQAALALLQRIRPLL GRGVSARSLIQLALYNPKGDRMIGGLAAMLRSLQLEAPGLSGQLIELDEPQSLVQRLKENAATGDVEIRY QAGQRQVQRWRPCPSVDLAVGTPWKDRGVYLITGGLGGLGQIFARAMAASVSDATLILTGRSAVDPQRVA EIDAGRNTIEYRQLDVSDRDAVQRLVAWIGDKHGRLNGVLHSAGVIRDSLLINKQDDELKQVMAAKVAGA RNLDLATAELPLDFMIFFSSGTGVIGNTGQADYAAANAFVDRYAAYRSQLVKQGRRSGRSLAINWPLWKE GGMKVDETIAQQMAESTGMVAMPTNAGIHALCQCFAWDQPQLLVMNGRREQMTALVTGGDDADRALAHEN ASQHQDVAPALPTDAEAPLAEPLRRALIDLVSQQMKIPAAEIRTDAEFSQYGFDSISLTALAGTLKQQWR LNLAPTIFFEHATIDRFAAYLEREHGSVLAAKLSPQQRAPQQQVKPSSSTPQQHGVQASKSALKRRPLTV AQSSAHQAVSSVPSKPAQEDDIAVIGVSGRFPMADDVEQFLRNLTEGRDCISEIPANRWDWREYYGDPHQ QPNKTNVKWGGFIHGVDHFDPLFFGISPREAQLMDPQQRLLMTYVWLAIEDAGYATADLAGSSTGIFVGT GMTGYSSLIAKTGVPVEGYSATAMVPSVGPNRMSFLLDLHGPSEPVETACSSSLVAIHRAVQAMRNGDCQ MAIVGGVNTLIAPEAQISFNKAGMLALDGRSKTFSAQANGYARGEGVGMIVLKNRSQAEADGDHIYALIR STAENHGGKANSLTAPNPRAQAELLKTAYRQAGVDPRSIGYIEAHGTGTELGDPIEINGLKMAFRELSEE LGIGPLQPGYCGVGSVKSNVGHLELAAGIAGVIKVLLQLKHKVLFKSLHCEALNPYIELDNSPFYIVQQS RPWLAAKDSNGHALPRRAGVSSFGFGGANAHILLEEYQPPQRPRHDVTSGARPILLSAKTPEQLREYARR LAEFIAAEPAEARLNPERYLDDLAYTLQVGRDPMPERLALLSDSLTDLQRQLADFAAGGKAVYRGRSEGE NRALALFRQDEDMAAALAAWIDKRKYHKLLELWTQGLAIDWRQFYRDGRSMQRLSLPGYPFAQERYWVTD LATGPVTDSVPGGGWLHPMLERNTSDFYRQRFSSRWRGQECWFADHQVNGRPTMPGVGYLEMARAAIAQS WDSKQLAAGWLQFKNIVWLAPYTLASQHNELHIELALEQQTINFRIYSQVQGDEVEHCKGSAQVIPAATV TPLDLEALAAGPWQRSVEAEQLYSLFEPINIDYGPSHRGVKQLWLGDGKLLARLELDAKWLSSDWVMHPG MLDSAVQASIGLLLQQAQGLNETLLPFALEQLNVYDGCRPVMWALIDVDRRGQSSAVQRINIELCDERGH IAVSFRGFSSRPLNGTRGHMASLTAGNRLPAGLSLLAPQWLVADHASTARQALPTLAIGAAGGRRNWLAE QHPQIEFLPSLATTIDGIAAQLAACAPFQRLIWLAPQPSTDFANQRLIDSREQSVLALFRLIKALLQLGY QQRALELQLILTASVAVRTGEPLAPEQAACHGLAGSLAKEYEHWRVELIDLPADAQGLPAATPVQRLPGE CLAWRDGEWFCQRLLPLAQQAQTDGGVSYREGGVYVVIGGAGGIGEVWTRHVIRHYRAKVIWLGRRAADD EIHRKLAALAQISQACNAPTPLYIQADAADVEQLAQARRQVVESFGAIHGVVHSALVLDDARLEQMNEAQ FTACLDAKMATSVRMAQVFTPADNPALDFVLFFSSMIAFSRAAGQSNYAAGCAFADAFAAQLNQHWRCAV KVINWGYWGSVGVVANAGYRARMAEQGLGSIEPDEGMAALDQLLAGALPQVGLIKLLEPMTIAGIDSGTQ LHCYPLEKPPASYVWTNVAQRLGPPPQHHSAATEMDRLLLALTFACMGELAGGGPLTEQQIAAHPAVAAN LDAHPFYRRWLRESLRLLAQKGYIDDQGQLLTAIPAAASLWSQWRQASDEWRRDGDLHAQLQLVETCARA LPAILRGEKQATEVMFPGGSMSLVEDIYKNNKISDYFNEALGEVVVDIARRHAEGNRPLRILEIGAGTGG

TTAGLISKLRPWRHQIAEYCYTDLSQAFLRHAEQHFAPDAPYLRTAIFDVSKACLEQGISTNQYDLVIAT NVLHATPDLRCTLQNAKATLCHGGLLLLNEISGRSMFTHLTFGLLEGWWLYDDEALRIDGCPGLSPESWQ RLLQSQGFGDIAFPVAGSHGLGQQIIVAVSDGVARLPAQQRVMPVADVTDVTDVIDVAVDASVAAIAPVA AIAPVAAIAPRVTPTIAEGEIDEAVLAKQCRQLITEVLSKLVNIAPERLQRDVAFDRYGIDSILQISLIQ ALEKATGELSRTILFEYNTINQLTDYLLSEHRAALTKHFAPSQQVNRPVAVQPVTAVAASHERAPRHAPR HVQPIDNHANSARRMATTTQASVVEHPATVAEPPTTVAEQPTTCRDIAIIGVSGRYPMAADLACFWDNLR NGRNCVSEAPNSRWSESLTGTQSWAAGRYYGGFLEQVEEFDHKLFGVPHEEVSNLSPELRQMLEVTWRTF EDAGYNSDAIARIQQRDAAGVGVFIGSMYHQSPWTESSLERAAIKSNVTDWQIPNRISHYFDLKGPSLAV NSACSSSMTAIHLACQSLLQNDCAMAIAGGVNLILDPSKYQTLKLANYLGSSDVSRGFGQGDGMIPGEGA GAVLLKPLAAAVADGDRIYGVIKSSSVNHGGGRLMYSAPDTQQQSRLIAQTIERAGLKPAQINYVEAAAN GSELGDPIEVAALKKVFGDMQPSSCALGTVKSNIGHLEAASGISQLTKVLLQLQHGQLAPSINADPPNPH IRLEGSAFYLQQQVAPWPAPVSAEGAREPRRCLINSFGAGGSYASLVVEEHLERRTPLRHRQGQTQLLVF AAASRHSLLAYLKKFNAFTVAHPSLELQDLAYSLAQREHRLTHRAAVVADTMEQMVARLQSLLSDELSVE GCCWISPFDGIEDGEAGTASGTLAQMAAAYCRGAQLDTSTLYPEGGNRVALPEYEFEHAMAQPSQVAATP QPLFNNLLYRRISSGELNAEQFEQLITTV rhiE ACP KS12 KR ACP KS13 DH KR ACP KS14 ? ACP MAGMTAVEPLASIYQISEQIHIGDSYRTLKALYQRQDDGEALSRITLAVSDDAESRHYSLHPLLINSAFL TVIPLLASEQLDSNFIPFGVKSLVLHRGQAPATGWIHTQLVKNSGELVLFDAQLYGDDGVLVAEFSGCSL KRLRGSHLVDDKARRDSDSGCSREGIEDYLLAQLQALGAKQIGKKQRHRNLMELGLESLQLVNLTSRLES AAAIELEPTIFFEYPSVAELATFLWQEYKAAFTPLLAGRSETTDVAPVKTSVTPVKVSDASPIAETCSMD ECVAHDSPKAVSGGDRQQDIAIIGMQGQFGGADDLDQFWQNIWQDRELIKEVPADHWDVAPWFDADPDAH DKTYSKWGSFIDNVDKFDADFFHLSRREAQWMDPQVRLLLQSTYAAAENAGVIRQLRGSRTGVFIGSCFN EYVDKITELGLPMDPYIATGSGVIAANRISFWFDFKGPSLMFNTACSSSLVALHAACVSLRNGECEMAFV GGSNLLLSSWHYRYFSAIRALSPTGRCHTFDAQADGYVPGECVAMLLLKPLSKALADGDPIHGIIKGSAA LHGGYTPSLTAPSVAGEENVIVHAWQDAGIDPRSLSYIEAHGTGTKLGDPIEINALKRAFARYTNDRGFC HIGSVKANIGHTEGAAGIAGVIKVLQQMKHHKLPALGHFKQQNPHIKLDDSPLVIDREGRDWPEQSAPRR AGVSSFGFSGTNAHVVLQEYREQREFATHQGEKVLVPLSARNASRLKEQVARLLAYLAQHTPDLAALAYT LQTGREAMATRAIFMVDSVEQLRRQLQAWMAGEPGVDFGIASMTAEEAVAAGDMRQLAARWLAGAEEAEA LDWTCLYGEGPRPARIGLPSYAFAKERYWLDAPAATVGQRERAVTETTVATETTVATYTEQWQEVDEPGP GAPIKRLICLLSEPGLRQQLVQQVRALSAQTELIFIAAGNRNERDDDGHYRVAVDDPQQLQEGLQHALSA HGASRVLYLWSMDDRRWMIDNSAIVALLKAMAATAAPIDRLLLAGRAGDALERCYLESWIGIERSLGAVM AHCPVEVAIDLPDNTGDDSRWLRRLWLQLSGDAAGGRLYQSGRTFQLRLASTRATAAVEPLALEQINTLL ITGGLGGLGLLLAQDLSSRAKRRSDGQLTLILNGRSSLSAAQQAQLDSLRHDKCSIFYLQADCADRQAIA AALAEVLPQSGPIDGLIHAAGLSAQGSLFDSAQADFDAVLHPKVKATLVLDEVLAAQPLALICYFSSSSA MLGDMGACSYAMANRFQQAYARYAQAGRARRVVAIHWPLWRNGGMAVGEQASTEFYLKSSGQRMLENAEG LTLLQQIVASDADHMLVLAGEPARLQQLVDGINDPARKATANSTVKATAAQPMSERTRSRPELKGLSVEQ SLLWDLRDLASRPLNAERHTLGEDTNLADFGFDSISLAEYAGLLSRHLSLKLTPELFFSHSTLAKIAAYL LAHHRQAVEACYRGEVISATEPLPIPAPVVASTSSADTIAIIGISGRFPGARNADELWRVLAEGRDMVGE IPADRYDWRDYYGDHREDPSKTRCIWMGSVPGVSEFDPMFFEISPREAKTLDPRQRLLLQESWNALEDAG VGPRHLETQRVGMFVGVEEGDFQRLASEESLTSGHNGILASRLAYFLNLTGPTMAINTACSSALVALHQA ALSLRNNECEIAVVAGVNLIFSPDAFIGMTQAGMLSPDGKCFAFDRRANGMVPGEAVCCVVLKPLSRAEA DGDPIYGVLRGSGINYDGKTNGITAPSGASQQRLLEEVYQRAGMNTEAVEYIVTHGTGTQLGDPVEINAL NDAFRGNKPGHCALTSTKTNLGHTFAASGLVSVISLLQAFRHETIPASLHCEQENDYIHWQQSPFYVNKT NKAWPAAGRDSERLGAVSAFGMSGTNAHVVLESYSRERDASPFRRPCYLFVLSAKTAEALKEKIEQLSAA LQQGGYRDNQLPSISYTLLEGRHHFRHRLALVAADLEEVLYTLAQYLAGEKRPNLFVGEVEREFSAQKTI ARYINQLLDDSRNASEDETRELLFGLADFYRQGYDIDGRRLFGAAQNGAHSMPPRLPLPGYPFAREHYWP EGRRRQRQPTLVVNQPMERLHPLVHHNISTLATQRFVSRFSGRETFLADHRIGDQLIFPGAAYLELAREA IVRASELPPQQVTLQNVVWLRPLAFAVGGGDRDVELYCELAVNGNDSVSFRIYSLDGGTQQLHAQGDAQL AAVAAPLPQPVDLAQWAARCNVSERSHDVLYHDFDTMGVHYGVTFRAAGQIRIGRDRVIGRLIHEALDPQ LEGVLLPPGVLDSALHIAASLESRRQGAAEPMLPFALESLRLYGSVEQALRAGPLTVTAAYSEARGGGAI EKIDLQICNDAGQCLVQLKGFSSRKTGVEPQPAQAPVMADSDEAADSDETLGRLIRTPFWKPVGSLGEWL PADAKPQLLLLGLPETTVSEIRRQFGNQVSVLPGAPGENDAAAYQAAALALLEWLQRLLSGHADGYLQLF VGQGQDDLRLTALDAMLKTAMIENSALKARLVALDPEMGNDAMVKVIVEQSRYHSNELVRVFANGSLYSR QWRELAPAQQNEQAPLRDGGIYAITGGAGGLGLIFAEHIVSSCRNPVFYLAGRSTVSQPLQQKADRLRAL GAQVHYQALDVGNAAAVRQWIDDIYAKEGSLHGVIHSAGVIRDSMIINKPASEFEQVLAAKVAGTEALDQ AINERALDFFVCCSSQAAMGNLGQVDYAAANAYMDAFMQYRQNLAGDGKRKGRSLSVNWPLWRDGGMKLA PVIEQQMRQRLGIVPMPVEEGVKSLWQLLNNPVSAQGWVIYGESSRLTAIGQPVDAKPQAPAQPAPAAAT ASLSDSELKKRIEAFVTRIIADVVQIDTAKIHPSEKFEVYGFDSIMAVGVTNELEKYLGSLPKTLLFEHV NIAGMVDHFAVKYRDQFVAMFSASEEQQETSRGVQVSTVEHQVPTMKQSAVEPALAQSLPLNRFAAAHSN ANSPAASSGTSIGSVAPVAPGTSVALGTSVASGASGERVEDNELANYIAVIGLGGYYPGADSIDELWQNL ANGVDCMSDFPADRWDHSKIYYKNRKVLGKTTCINGSFIKDVDKFDYSYFKMPKVYADHMSPEVRLFLQV AVHTFEDAGYSKETLLSRYNGDVGVLLGTMSNDYHYYGFESNVFRGSMASGSGMATIPMTVSYFYGLTGP

SLFIDTMCSSSSTCIHTACQMLKHDETKMVLAGGLNLMYHPYTTVNTSQGNFTSITSESVNSYGVGADGT VIGEGIGAVLLKRLDRAIADRDQIYGVIKGSAMTNAGERNGFNVPNPDLQTLAIRQAMDQAKVHPSSISY IEGHGSGTKLGDPIEVLGLNNAFRWATDDKQFCYLGSIKSNIGHLLAASGIAGLTKTLLQFKHKQIAPSI HSSQLNQDIDFADTPFVVPQQLIEWRQPERIINGRKQVFPRRAGLTSIAAGGMNAHMIVEEYPEPADSAG QISEDQLVFVFSVHKLALLAQNLTSFRDWLASSEAPLAQIAYTLQVGKNNLRNRLAIRCRTRQALSRALN ACIDGHYQSSADSKIFYRFQESDAVQPLESDLNDPLAPLLTQWLNGDSQVDWASLYAQPPVRISLPAYRF EKTRCWYTEEGYESSIVNPLMFKNKLHPLVAKNCSTPQPGAIFRTDFVEDELLDYVYSGRGGRRLSAFNF ADVALAMPALASRFDGRTLSVSCAFEHYIADWTTVTGLEYRLFEIDSEQLELEFDFRRSGEQPTHLGFAV INPLTSDEPPLPQQWLDDARELLNRQALQAGRQLSAAEVSQRLAQAGYDFAPYLDHDGELTIGRSGLVLK GRPPVNRHNHYADNVQLSPYLATTIDKALYLLLDELGLPQGRVIVRNIERLCCYHTPAGGFSVVLSGIGL NDNELSLSLLVLDEREQICVKLDKVSLYLGKQEVASVDRKHSLLTGTVEMANMPAAVLARPLLEPAGQPT TARVEKQEAKPQADDSEAGFGEKILAFIQQELQDKLGFAAQDIGESTQVHDLGLDSIMVVQLTDSVNKRF GTKLMPDLFYEKQQLGELVARLEAA RhiF KS15 DH KR ACP (KS16) ACP TE MGRAFRAMEKTTANDLNDISLPTQRRAGQRQTVQQQTRRQIGGGVDSGAKTEPNASKVAIVGFSGRFPGA DNTEEFWRLLVQGHSAISEFPYWNVPGIAERRHLRKEFACPGGFIKDPMAFDADFFKISAREAEAMDPQH RIVLEQTWAAFEDAGIPPQSLRGSDTGVYIGVSSADYNGLLARTAAGAHDATGNAHSIIANRISYLFDFH GPSAPVDTACSSSLVAVYKAAQAILNGDCTVAVAGGVNLCFEPMVFIGAAKAGMLSPTGRCKTFAADADG YVRGEGVGVLILKDYQQALADGDNIVATIIGSARNHGGHANSLTAPNSTAQANLIKQACRGVDIDSIGYI EVHGTGTRLGDPIEISGLKQAFAELGRSSERRCYLGSVKTNIGHLESAAGIAGLIKTLLVLKHGYLPKSL HSEQLNPYIDLADSPFEVLQQAREWPQQSDTPRRAGVSSFGFGGTNAHIVLEAAEPPVGVTAQGSAATIF PISARTPDALKSRVKQLIDFIAQRPQLALPDLAASLQLGREAMECRLAIVADSRDSLLDQLGHYLTNGDD QGDEPAGDIATGEVLRALQQQDRDTLLALWCRGATVDWRQLYPDGRAHRIPLPTYPFSRETYWISAALAV EHSGEPILHPLVQRNTSDLAGQRFSSRFNGNEFFFDEHRVNGVKILPGVAYLEMARAAVELSLADDEALV QFKHIAWQHPMRHDGGELAIDIELSEQDNGEILFEILGATVDGPSYCRGVALLGTAQALPQLNLPAIAAA TEQQRLEPQQCYQILGKMGLNYGEHFRGISELQAGNGQVLAKLALPGEPSEADECDKSLRLPPGLLDSAL QAALGLALVDPTQSDARREPLVPFALDGVILGDLNLLGNGCYAWVRYAANHHPGRINKLDVDLCDAQGRV ALRLLGFSSKRLDSSQAKSLVMAPIWRDKAPRQDGERHYNRQLILLAGNQPIMLDKLADCCQERRSGRQI SVERLPAAAEDPALALQSLAGVLLGYLKDNRSDSLVQLVLLDSDHGPRLTAPVFASLQALLKTAKNEGLI AAGQCIEVSGIHSPESLAQLLIEDSDQDDERVRYQDSVGTRYQCQVASWRETALAATGTAPWRAGGVYLL TGGVGGLGLLLAEAIAREAHGAKLILASRSAGQLSSKAAERIADIKKLGAQVQLEALDVADRTAVDELIA RCEREFGGINGIFHCAGLTRDSLLNNKSEADWAAVLRPKVAGVLNLDRASAHLALDCFVLFSSVSAVIGN VGQGDYALANAFLDEFTGWRNRQTAAGHRHGRTLAVNWPLWRNGGMQIDPQREQLMVEQTGIQPLSDHGG LELLRRALADTSAPERLMVLEGNTAKIKAFIAAQWHEPVSAMFDEPVAAEQPAAPTTQILVDEPSPVANA NDESVHRDLTEPAIRYFKQLLSTTLKRPVEKIDSDGSFERYGVDSIILTELTTKLEQSFGSLPNTLLYEY QTVRELSEYFIHHHRDALQQRVLGEPVNRRTTAKNEQKTEPVAQVEKVEQIAVATQLPARKRRRRAARQD TPSMANSSRELAIVGISGRYPGAEDLEAFWHKLAGGEDLISEVPTQRWDHQAYFADQRDRFDKTYCKWGG FLDGVEDFDPLFFNLSPREAEIINPNDRLFIETCWNLLESAGLTRQRLKQQYQQQVGVFVGVMYQQYQAF EADFVRESLVSVTSYSAIANRVSYFFDFQGPSLAIDTMCSSSISAIHAAGEALRNGDCRLAIAGGVNLTL HPKKYIGLSIGKVLGSHASSRSFADGDGYLPAEGVGAVLLKTLADAERDGDQILAVIKSTAVNHGGHTHG FSMPSAKAEAALIDSNFKRAGVDPRTISYVEAAANGSAMGDAIELSALNRVFGQAGVAHQSCAIGSVKSN IGHAEAASGMSQLSKLVLQLQHQQLAPSLLLGSLNPKLDFENSPFVLQRELGHWPQPVVETDGVSRQYPR RAALSAFGAGGSNAHLVLEEYQKHQQTPGQLEGNVAQVENGVLYIVPISAKSVRSLHQGVSRLARHLDTH PDLRINDVAYTLQVGREAMPWRLALLVKSMDELRAALYKIVQVLNRGDGMAALEKLNLPLFFGNIDEVPA AIASLLSGPGADALSRSLMAADERQQLALFWTQGGEISWDNLAENTSAGYGVKIVSLPTYAFDKKRYWLE QSNTPKTLHDNAMAASATQQTSDSTAVNVVDEHVSHEETAAEHGLRVLADLLGMQPQELSPAKPLSVYGA DSIVMVQLAMRLQAEIDPELALANIQQCVTIQDLLALLNERGERASAKGPMLPVKISELFTRPTTHFLEL QRLNTVDDGRPIFWFHGALGGTEIYQELAHHIDRPFFGLQAKGWMTEREPLQGIEAMAAYYVQAIQSVQP QGPYDLGGYSLGGMLAYEVTRQLQESGEAVTTLVMLDSPDVTGERTAKLADKTRLLQAVNMSLQMTISDT PERFAEVLIHRDEIDLSLSHQEYRQQLMTLARQRGLKISDDRLQQMMEQVARIQQSYQVEHYQILPLPKA EEVACYYFRNASGLWMGDLEPYFSTDSQEFAAFNHTNYWQEWQRQLPSFEMIEVNSSSHMTLLTEPEVFD VIAEFCVSLYGQELIEGKRGVRTVLT

Virginiamycin M

virA KS1 DH KR MT ACP ACP KS2 DH KR ACP C A PCP KS3 DH KR ACP KS4 ACP ACP MAVPDARGPAEEDVRGAVAVIGMACRVPGADDVDAFWSLLAEGHCRIEPVPAGRFAGSPAGDPAAAAPRAGLLDRIDLFDARFFSVTPRQAASMDPQQRALLELSWHALEHAALDPDDLAGTPVGVFAAACSYDYREQLVERDAADGYATVGTFPAFLANRISHTYDFTGPSITVDTACSGALTALSLAERAIRSGDCEIALAGAANLLSNGFNNEAYRRAGMLSPQGTSLVFDRGADGFVRGEGAGWVVLKRLDRAIEDGDPVLAVLRATAVNHGGRAAALTAPNPRAQAALVRTALDRAGLHAADLGFLEAHGTATPLGDPIEIDAVREVLEGGAGGPVTRAAGPLDRLWVGSAKANIGHLEGASGLAGLIKAVQVLRNELIPGTPNFTELNPHIDLDGTPLTVADHPVRWPRVDGSPRRAAVSAFGFGGSNAHAVLEEAPALDGPGAANGNGVLLAVPLSAATARSLVRLAGRLADRIGKEPSGLDLQQIAWSLQSGRRALAERMLVVARDTGELADAVRAF

AAGETHPATATLERPDALATLTDERARTALLQWLSGGTADWAALWTVGQPPRRVPLVPYPFEREPYWLPGEPAARPASAVAAPSGPAPTAVVATAAAVTGGRTNALVLPAGHPLAEHRVAGRAVAPGALLIDALAGGGPVALSGVRFLRPVPFDDGLRLERGTDDGHGRTALTVHHDGHVHARAVADPGTPEPLAAGDRTLADGTPVDLADMLHRAGIDVGTAYHAVTALVRSGNRAAGRLTPPAGDPLTRRVGWLDAALQAACALAAPGSTLMAAALGRVFWSGELPDRADLLLHLVEDSPEHVLVDLDAVTEDGRAVLRVRGLRLVQAPSAPASTAPAQAAQDSAPIRVLSPVWAEESTPRPAPAGTATHTVTLYDRHTERAAEGLRGDVATLLPVGPDGVDRDRLGTAVRAAAGSPLAVTLLVGGCRWTEDTAGVTALRHWLTALLTTAQVLAESGTPAEVRLLTTGLGAPDGESPAPGASLQGALLGALRTLPLEVPTVTAAAVDLPADALHSAAFEPIAAAVAEPCGRAVPLVALRGVRRLRQVLAERPLPDARGFRPGGVYVVFGGAGGIGGEVARHLAARYRASLLLVGRSAEGEDVRNLLEDLRAAGGQAHYHRGDVTDAGDVAAALARCRTDFGEPDGLLHSVGSVSDGLLTGLTAADIDHVLETKVTAVLTLRRALAGRPGTALVLFSSVAGLFGSVGGLNYAAANAFLDHYAAAVDGDGGLVVRTFDWGLWRGTGLARQYTAHVRRQYPGLTDFEPERGVAALEAGMSGTDPQTVAISGDPEPLRALTRPAAADPAHLLERYARGALARTMADLGLDHGTARAGCTAAADLLGVVPEHHRLLAAVLDLLEGEGPDARSAVHLATDRAALLAGHPDLLGHVELLDRALASYGPVLRGEQPATAVLFPRGDLGAVSAIYSNNQLFDPVNAAVARELAADAARIAREGRRPRILEIGAGVGGTTASALAAMDALGVTDAEYAYTDVSRAFLQHARRRFGERVGPQLLDIEKSPAGQGFATGHYDLVVASNVLHATRDLTLVLRHVSELLAPGGRLLLVEITVPAAVYTLTFGLTDGWWRYVDTQYRLPHGPLLDGARWQALLEAGGWTLAGVGHQRDVPGCVALLDCRAPSAPAADVPAAAAATRTPAADGTDGTGGTHDRLREIVRELLGDPRADVPGDRPWQELGIDSLLNLELVTAVSKAFGEISSTALFEHRTLDELARALGGRARPAGATAAATAFAAAEAPDEAPAAGDGDATGDGAGAADLLAELTGLAADLTGQDHALIDQDCDFPGIGVDSLLNGEFTAALRQRFPARAIPSTVLFEHTSLRSLAAWLAAPTRRARPHAVTVAAATPPAPLTVPATLPVSPDAAARSAAGPRPARPAVPAEPSGHRAPVAIVGLAGRYPGAEDIDAFWRLLSEGRNPVTEVPAERWDWRTARTLGGGYARWGCFVDGWDRFDPELFRITPRDAAVMDPQERLFLEVSWEAFETAGYSRRTLSGSAGGPKVGVFAGVTSNSHLIAQHQARLAGADNPEYAVTAAASVANRVSHAFDLSGPSLTVDTMCSSSLTALHLACRAVQDGEADLALAGGVNLYLHPDRFAGLCALGMQAWRTSRGDRTRAFGAGGDGFVPGEGVGAVVLKRLDRAEADGDTVYAVIRGTGLNHGGGTGGYTVPNPLAQAAVIGTTLDAAGIDPAAVGYLEAHGTGTELGDPIELRALALAFDGDRPATAGLRIGSVKSNIGHGEAAAGIAGLTKAVLQLRHGQLVPTLHAEQLNPKLDLDGTSLHIQRRAEAWPQSVDAEGRTLPRLAAVSSFGAGGSNAHVLLEEYPQTAQPAPARPGADRTPVLLPLSAPDPQRLRTLAARLAGLIAHVPGSETLLAATATPTDIAHTLRVGRETWPHRAAVTASDPRRLREALTALAEGRPHPDVATADTADHAEAVARAWVVDGRPPAQDLPGRRVALPTTPFARRRCTLTAPEGHDPLLGAPIDLPLADSVRIPATRTVTARLGGASRWVADHVVDGTALLPGAFHPELVHEALLTAGESPYRQVIRDLMWPAPAAGLPMTVRAELAEPGADGTRSFTVEAVTAADGERTAARGWTEAAVADRVQPSLRYRPEDLARHLAEGVDAEDFYRVFAGHGFAYGPLYRTVRRALRDGEETTARLRLPDGEDRDGRQVLHPALFDGACQTAAFLLLCEDPAARRRYRPLSVNRLAVHAPVTGEAYVHARRVRAEEASGTHVFDVRLVDAGSGEVLAEAEGFRIRVEDRDAPAAPARTADTATTAAAFAPADGDRAPAVATYRLGWPDAPRPAAGRPIGTLWTVGDGALADGLAPQAAARLSFDRACDVDALAETAGRTGAPATVLVDLTGGPRGLGFGAEPLPAGQIAADWTDFRTGPIAQVFGLLQALVRSRALDGVLVLFATDDSATGPSPFQRALHSLVRTVAGETGRLRLRMASVGSGTAGTVLPDADADADAVAAVRAELSAEPADGEDWVRIGPGDRRRRAALAPVRDTGTADPAGLLRADGTYLVIGGQGGLGSEIAAAVRAARPTARLVLVGRSAPDEAALAQLRGPAGTGPVDYRRCDVTDLAQLAELAAELQRSGTELHGIVHTAGVLRDGFLRGKTPEMIEEVCRAKVLAAVAVDAAFHDHPLDFFVVASSLAALVGNQGQSDYAFANGFLDGFAAARTRWTELGLRSGRSLSVGWPVLEGAGMAPEPAALGYLSDTFGLRPLPVREAVRRMWPLLDLATGPWQAHAALVAGDQDLWSRALGVAADAAADTPEPREAPAAPTPAVADAAAAADPAPAADGRTAALRWLAERVGRAIGVPAAMIAADRPLLDYGVDSIAVMRLSRLLEDDLGRLPVALLLDSSTLGELTDRLLRDHGAQLTAAVSAETGPAPAEAPAAPAAPAVIGAAPAPVDAAGTEAVPLPDRLIGMWTSDQAAAPLAPYNISLSWRLADADRAALAGAVDDLVRRHPVLGCCVRPHRGEPSFVPARTAPALVDRSPEVGMDLATAVRQEADRRFAPATEPLLRPVLWRDGTDTVVQLTTHHLAADGRSAELIGQDLAALYAARTGGGTALAPAPSFADVLRREREDAARTRAADESFWAARLARLTAGPLFPDADTGTDAASAQREYGLGADLSALLSATARTAGVTPFTVLLAAFAASLGRLTGRRSFLLAVPAYGRASASEDDAVGCFVNSVPLRIDLDPARPVADWLTSLHDEVRGAVGHAGLPYPRLTELCRAAGEHTVPTVTFAYQNWRRDTAGAAPGGRTDIGLPVHRRGQRGHFDLGLEVTDGPDGMDVLANHRTGALDGPAVDGLVEDLRRMVVELSRDLDGGRTGRLLDPAGSTLVSRFADSVRRTPDRTAVEDRDDTFSYAALDELSDAVARQVSRATGPGEPVAVLMHRSARLAAVLLGILKSGRPYVPLDDSYPADRLRMVVEGAECRLAVADPDLAALLPATLRVLPAAQALDPAAAPEPDSGRGTAPLPGDLAYLMFTSGSTGRPKGVGVTHGNVVHTLEAIAATTGTGPQDRLLAVTTVCFDISVLELFMPLLTGGTVVVARRTDVVDARRLADLIESRNVTVLQATPAGWQLLLDGGWRGRAGLTALCGGEALPPNLAAGLVSRTGSLWNVYGPTEATIWSTIGRVDGAAVHLGGPIGATDLVVTEVDGTAAPAAGEPGELWIGGPGVAQGYWRRPDLTAERFTAHPARPEGGGRWFRTGDLVRRDEQGRLVFLGRADSQVKIRGHRVELGEIEAVLGTHPGLARVVVVLRGEGALVRLVAVAVPARGAAAPGLDELRAFAAASLPAWMLPDRLVTTPELALTPNGKVDRKAAALLARPAAEREAATDPVRSADPAPAPVPMPPAVHAPAQADPARIRQSVTSFWAELLELDHVPGDRRFFDLGGNSLLLGRLFARLEDRFPGTGLEVADLFARPPSTTRWPCSPSGSPRPHPPPRPPRPPRRPDRAAPFRSRCPPVPPRGTARPSTRRRPPMNHDHHPYDAVDDPNAVAVVGMSCRFGPATSADRLWELLEQGRSGIHRYSPEELVRLGHRPELVRRPGFVPAGVVMEDADAFNNEFFGYSPVHAEWLDPQQRVLLETAWHALEDAGFAPDRTGLRTAAYVSVGQSTMPQVGITDLDAAGMIRFSSSDKDFAASRISYKLGLTGPSLTVQSACSSGLVAVHLAVESLLGEESDLAVVGAASLHFPQAGYLAAPDMILSPSGECRPFDDGADGTVFGNGAGALVLRRLADAVRDGDPIRAVIRGSAVNNDGARKMDYHAPSPEGQEAVLREALAVAGIDAHTVGYLETHGTGTHLGDPIEYAALDRVYGGERPHPPPSAPSRASSATSTPRPDSPAWPRLILALEHAAVPPQAPFEKPNRRLAGTGGLRIAAGGDGWPVPDGPRRAAVSSFGIGGTNAHVVLEQAPDLPAPPAGNGHDEHRVPVSARTEEALRQLAASLADSLGRPGAPEPADVAHTLSTGRSHRAVRAVLTARTTAELAEQLRTLAREGTAAAATSAAPYRAWIEGTGELPEPEPAAGRTGRRVRLPGYPFARRRWPRPDAPDLAPDNRSPEAATDALPVRTVRPGDPLAADHLVGGLPVFPAAAQIDLALTAAGRLAGGPAAGLADLAFRRTVEVVDPVELRVEIEDGQVRVASTDVHSQARLLPAGAPERPAPLDLAALRRSYPESAEPEALYRYFADNGVGYGPAFRVLRELHHGPAGVLARVTAAPESVPGETVSPCVLDGALQSVIGCVLREDLAGETFIPFAIDELTVHAPLP

GEVWVTVSPQRLAGGGRRVRRYDVAVAAEDGAVLLTLRGLALRPVTAPAAAGAPAVPQGVHLFASTAEEFAPTGRDAATAGPLVLIGDTALDGADLVLPAPADPDAAAAAGAELAARLPAGGGRPTIVWPAAADDPHTDPAATATDGALRVLALLRALLRPLGRRGAHLVVPYPAGSPAGAVAGAGLAALGRSLTGENPRFDLTALAVEDGAGPAGLRRALDALTVRVPLSRALTVAADGGLRTTVLAPLTPAPRRALLDPRDGRPSTLQACKLGIGIHGMGRLAALLAEHLLDRHAARIVLTGRSAADGARGEELRRLADRAARTGGSVEYRQLDPSDPAAVGDTARRIAADGPAVNGVFHCAGVLRDGYVLRKTVADARDVIVPKLVGAAELDSATADWDLDCFVVLSSVSGALGSAGQADYAFANAAADELVRRRADRAGRGRSVSIAWPFWADGGMRPDGPAQEELATLGMRALPTEAGLAVLESLLAGPATAPVVLYGDREALLASFPLLTSEAPAAVPEPAPAQAPAPAAEQAAPAAAPAGEVTAVLHRRLAAVVAEATRTPVDDVTADRLFDDLGIDSLLAIRVVELLEKDFGRLSKTLLFECRSVEELAEYLREEHPERCAALAGGPKETTAPAAPAAQAPAPAAPAQAPAPAVSAMPSGPSDDDLADPRAIAVIGVAGRFPEADGLDRLWRNLTEGRDSITEVPADRWDAEALYDADKTRVDRTHTKWGGFVDGVENFDAALFNISPREAGIVDPQARLFLESCWAALDDAGYTPDRLVSAAEDPVHRRDVGVFVGAMYGEYQLHEAEERLRGNPVLANSAYWSIANRVSYFFDFQGPSVAVDTACSSALTAVHLAVESLRAGTSRVAIAGGVNVLIHPNKYFMLGQGRFASSDGRCRSFGAGGDGYVPGEGVGAVLLKPLRDALRDGDHIHAVIRGTAANHGGRTNGYTVPNPRAQADLVTKALRDAGLTARDLDYIEAHGTGTALGDPIEIRGLASAFARDGIKGPGSLPIGSVKSNVGHLESAAGSVALAKVLLQLRHRTLVPSLHATPPNPEIDFDGVPFSVQQQLAPWRTHDGAARPLRAGISSFGAGGGNAHLIVEEAPAPAPRPATGRREPQVLFLSARTDTALAAYARDLRDHLLRARSAGEEPSAADVAFTFAVGRVDLARRAVLPADSLDLLLAGLEALAEGRPRPVPPAGEEIAAWLSGRRIDREAACGAASVGRRIPLPHYPFERVRCWYDLQIAHLHRQGLGSAGQEPAFARDHLRDFGRAPSDRPQAMPGTAPAPAAVPVSAAEGAQVSAPTGVPARAAVRPAVPAPTAVPTLTLRGAAEPARRPATDPMEKPQMTSDRKISLRPLAPATAATRPAAPATPATPAAPAAVPAPPAAPAPAAVPAGRQEEIAEEVARLLAGVLYLEPDRLDPEETFLTLGVDSILGVEFVAAVNAAYPVGVKATALYDHPTPAAFARHIAESLGAPAPAPTFAPAVPASPAVPAVAVDPAPVARALREELARTLYCEPGDIDDEASFNTLGLDSILGVEFVAFVNQTYGLDEKAGILYDHPSLAALSRHVAGRAAPVPAAAAEPAALPLPVTGAGEPSQADLDALLSAVRDNRLSIEQAVTLLTPRR virF KS5 earlier start codon? MPPERWRTEEFYDPDPAAEGRSVSRWGAYVADADRFDADFFRMTPREAELTDPQARLFLQEAWRALEHAGRDARSLAGTRCGVYAGVMLNDYQDLVERESPYKRLPQVMQGNSNSILAARIAYHLDLKGPAVTVDTACSSSLTALHLACQSLWLGETDLTVVGGVTLYLTELPHVFMSAAGMLSPNGRCRPFDAAADGIVPGEGCAVVVLKPLSKALADGDPVHAVIRASGLNQDGRTNGITAPSARSQTALVRDTLQRFAVDPAGIDYVECHGTGTPLGDPIEVTALNEAFAGAGLAPASVPIGSVKGNIGHTSAAAGLAGLLKAAGVVRTGLVPPSLHYARANPQIPFDQGPFTVAGERRELGRPDGGRPRRATVSSFGFSGTNAYVVVEQAPEQAARPAGDDGAPPVLVPLSGRRADAPAAHAADLARWLRGPGSDASPADVAHTLAVARTHHTYRFALLVSGRDELLESLDLLAAGSADPRRTDTAPDAAAPDAAVRRAQAALLARLVERAGENPGPVELAALAKLYTQGHTVDWAAVSPPARHRRLSLPAYPFAPHRHYVERPAPVTPPTPAATSALAEASHGTPAEPAGARTPQEALADVPLTEPVLHRQEWIPAPLPAAAPAPTAPVLVHDPAGDLAAALAATGLDVHRLGGDRTAAEALRATGAQVVTVVLRLTPPADGAPATAVDLAAFEAARAALAVLRTQQLTLLAVTADPPEPTRPERSSRPSVRRTPGSPAARC virG KR ACP KS6 ACP MLTADGTPDARRLLAEIAAPAAEHGHLADLRSARRLRRVLVPVPLPGTRPFVRQDGVYLVSGGAGGIGLALARHLTDRPGTRVVLCGRTAWDDLAEATRSAVSGSDRLRYARADVTDPEAAAALVAEVVRTEGALHGVFHAAGVVRDGYLVRKDPRDVADVLAPKILGARALDEATAALPLDAFVLFSSVAAVTGNLGQSDYAFANGFLDGFATRRAGQVARGERHGRTLSVQWPLWDVPGMSIPEPVLEVVAQHTGMAPLPAAVGLAALERLLAADGPEVVSLFHGDAATWRAHLAALHLERPAAAGQVTAAAPAAPAPSDTPVVASADPAAADDGRRAELADRVSRTVADTIGRPAGSIGGHTSLESMGLDSVMIRALASRLSAEVAPVGPEMLFGLRDLDELVDHLVAARPVPVAEPATPAVPPAPAATAATVFAPVAPADPAVVPAAPAALPVPAAAPASASRTLPAPSADDRFAIIGISGRYPQAPDLDAFWQNLLNGKDTASDLPTDRWPDAAGVNARGHFLEGVDAFDPTFFGLSAHDGTLLDPQERLFLEVAWEALEDAGYTGSRLHDLVAPDGERRSVGVFAGITSSDYKLLGAERWAAGHREMPSGHYWSLPNRLSYLLDLRGPSQPVDTACSSSLVALHLALDALRRGECAAALVGGVNLYVHPSRFRMLRRSGFLAEDGLCRSFGAGGAGFGPGEGGGAVVVKPLAVALADGDTVHAVVRGSAVAHGGRTNGFTAPSPWAQARVLRAALRNSGTDPETVNVIEAHGTGTELGDPVELAGLQDAYGSGRVPCSLGSVKSAVGHGESAAGIAALTKVVLQLRHGELVPTLHADPVNPGLRLEDTRFVLQHTPGRWERLTGADGSPLPRRAGISSFGAGGVNAHVIVEEYLPEPHGRAAAAEPGRPELVLLSAPTREHLAATADRLARRLEGPEAPADLRAVAYSLRTGRSAMDCRLAVVATDTAGLAAALGAFARSADAGEGESAVRYADLRDGRRAHRDLDTVPETTAFLADLWRNRRLHQLGELWLSGLDIERAAPREPGTRLVPLPTSAFLRRRLWITDPVTADTTPTPDPLPTPDPLPVPLSAPAPAPAPAPQPAPTTTPAPAAAPAAAPARSGEAVTEQLSRLVAGFVPDAAGSVDPDRTLLEHGIDSINLMNLRFEITERFGRTLPLQLLSESTVPVLAAHLSADRAHDRA virH CY CY A PCP PCP (KS7) ACP MTIQNNAADRYQPFSLTEVQESFYVGRTAGGHAGGTQIHLEFEADHLDPARLRESWNRCVADTDMLRAHLLPDARQAVLEQAPEYRFEVRDLTAVGRDELRASLERMRRESAAAIDPHRWPLFALAAAELPGGRTRVMLTVEELIADGPSVSLLVQDWYARYAFGEEPGVPEISFRDYALATGGRRPSEESLAYWRDKLGAVDFGRPLPLARPDADPAAAADGEHRRMTLHLDREQWDRAKEAAREARATPSAMLLALNAAAVGTAGSGPLPLVLTTYNRLPLHADVARLVGPFLSTSVFVAPEAAGTLGELLGEVSGQLWRDLEHGDVSGVRALRERARTEPGRRAVPVPVVFTSLLGSVTDRRAADPGNWAALVDVDASATRTSGVQLEMCVQERAGQLHVSWDYLPGALDGAEVRAAFERLGALLRRVAALGPAVWNTGLPATAAPDAGTETAGRASFGTAGRLPLTEVQSAYLVGRLGTLGGATETRVYQEFLLENHDVDTLEAAWNRLVAHHPMLRAAVHQDGTLEVAPAVPHYRITRHDLTGLRPAEGPAADGGSPVERALADTAARLRGGTFPLGSRPMYALEASILPDGTTVLHVVLDALLADARSFALLFGQLFALHDGDSSVLDEPADPGPYLLGLPAHGQDGSAEAARLAWREKFAALPAGPPL

PDPAPQAARLHRRTDLGSWRRLTERAAAIGVPADMVLLTAYTDELRRTFGPEPFTVTVVSWDRPAGLAHADRMVADFTQLAWVVVDDTLPADFAQRARELWGRVRADLERGEFRPGLAELRGRVFRSGGRLRLPVVFTRVPEIDPALHPRGVRLRESQSQTAQVALDHVPLLVGDDLVGQWDAAEGCLSADRMDTMFEGYARRIRSFVESAGSAGSAGSVESAGSAGSADELSATMTGLLAETLSRHPDRPAVHWDGRVVDYRELDHRTARLAHQLIASGIRPGDHVAVHMNRSDDLVVALVGIVRAGAVYVPVDPANPPERVRYLLEDSGARVVVADAALAAVPAAAGAVVLCQDRDEDRALLASRPVTPPQVEVGPDDPVYTIYTSGTTGKPKGCRNTHRGFVNRVRWMQDRFPLGADDRVAQKTPYGFDVSAWEFFWPLLAGASIVVARPGGHVDPGYLARLLREERVTVAHFVPSVLGLFLRDRAASDCASLRYVFASGEALPVATMKRFFQVLPDGAELHNLYGPTEAAIDVTHWACRPDWDEPTVPIGRPIARTRIHVVDERMARVPDGTPGEIVIGGAGVALGYHGRPELTAERFVASPFADDPSPRLYRTGDLGQLGPDGEIRYLGRIDGQFKLRGLRIEPEEVEAALTELPGVSEARVLPVTDPATGEQILAAVCVEADGTLAPSVGQMRRDLARSLPSYLVPSSFRFVDRLPLTANGKLDRRAATALFGTTPPAAPAAPAPVAPAPVVVPDPAAAAAPRPPALTGHPAPAIEEDPVYDPRNGRPDEGTAALVGAAVADCLRLEVVDPDADLFDLGATSFTMIRLAQEIERLTGVALSVDALISGPTVTALLAAVRAGRAAADRTEPETTGAAVPPGPQADVAAVADLAAGLLGLAEADPDTDLFDLGATSFTMIRLAQELAERFGADVPVDALIQTPTARGIAASLAPASAPQAAAAPRAAASAARTDIRIALDPQAKAAFKEARVAERRLPGSLARLPFPDPTPQDRRAFYDASSFREFADGPLPGDRLTELLGTLARGELDGRAKHRYPSAGGFYPVQVYLYVRPGAVEGVDGGLYYLHPGERALVAIDPQARFGTDVHVFHNRALVDASAFGVFLVSTPAAIAPAYGERNAGRFSMIEAGHVAQLLLTAGPERGLGMCAVGEMDFGAVRGHFGLQDDQELLVSLWGGALSGPAVLRRAELVAAERPQESAPVPSGPRPVAVVGFAARLPGADDLRGLDAMLAAGDCALGPAPQERWAPLRSNARRAGARVGGYLPDVTAVEVEEFGLADAEVAAVDPQERLLLTVTRHCLEDAAITPERLSQTGQVGVFVGSMWQDHALHGVAARAEGRTGTHATRGGLAHRMSHAFGLTGPSLVIDTGCVSGLAAVEAAFRAVADGRCEAAVAAGSNLVLHPDHLDVLSELGLVAEQEDSCAFTDRASGWLVGEGVGAVLLKPLDRALEDGDPVHAVLRGGALLHSGTTRQFGIPDPRRQEQVMRAALADARLTAGDIGYVEAAAAGAALADALEFTALGRLFGAAGVDGGADVEGASGAGNGARAGLGPVPVGSVKPNTGHLEAASVFAQLGKLIAQFRRDRLYPTRLTSAANPALAPYRGSVALAGPSADQWRTAPGGTRRALVNGFAGGGSYGSLVVEEPPAAATAAPADADTAVSEGTEVLVLSADNPENLARWARSLAEELDADPGLDLAAVARTLREGRRARAVRGAVAADRGRAAGALRTLAERVLRDGTGATVEAARTTADQQALTALWSAGGELPVPATSAVPRRRPLPPVPLSVRRVPLPVPAAASARPEKEQQPDGPTGTGPTPFERMAGIVAQEPGADPDRLAPADDLFAMGVTSRQLLRIAARVADDGGSELPLESLFTAPDLAALAELAFPIAVPA

Supplementary data 2: Analysis of NMR data for thailandamide A.

In the 1H NMR spectrum of thailandamide A (16), three secondary methyls (� 0.94, 1.09, 1.24),

four tertiary methyls (� 1.67, 1.88, 1.95, 3.14), and several olefinic protons (� 5.43 to 7.62) were

observed. The 13C NMR and DEPT spectra showed the presence of one keto carbon (� 201.8),

two carbonyl carbons (� 178.0, 179.5), many olefinic carbons (� 116.1 to 156.7), and three

hydroxy methine carbons (� 91.0, 69.5, 73.7). The 1H-1H COSY spectrum revealed six partial

structures; C2–C3, C5–C8, C10–C14, C20–22-Me, 24-Me–C30, C32–C33 (Supplementary

Fig. 3). According to HMBC, three positions (C3, C13, C29) are connected with oxygens.

Furthermore, HMBC correlations from 2-Me, 3-OMe, 4-Me, and 9-Me connected C1 to C14,

from 19-Me connected C18 to 22-Me, from 24-Me connected C23 to C30. The typical p-

hydroxyphenyl chemical shifts: � C 156.7, 116.1 (2C), 131.5 (2C), 131.1, and � H 6.69 (2H), 6.89

(2H), and HMBC correlations H30 to C31, C32, C36 confirmed a connection from C30 to C36.

Additional HMBC analyses unequivocally revealed the structure of 16, in which C14 and C16

are joined by an amide bond (C23; � 178.0) adjacent to C22 (� 47.7). Finally, the geometries of

eight double bonds consist of a tetraene, a triene, and one double bond were elucidated by

coupling constants and carbon chemical shifts of tertiary methyls. Three tertiary methyl carbons

� 11.0 (4-Me), 12.9 (9-Me), and 13.4 (19-Me) indicated trans geometries for C4–C5, C8–C9,

and C18–C19. Five additional trans-configured double bonds C6–C7, C10–C11, C16–C17,

C20–C21, and C24–C25 were also determined by large coupling constants J6,7=14,5 Hz,

J10,11=15.4 Hz, J16,17=15.1 Hz, J20,21=15.7 Hz, and J24,25=15.2 Hz, respectively. The identical

mass of thailandamide B (17) (m/z 716 [M-H]-) as 16 suggested that 17 might be a geometrical

isomer of 16. Unfortunately 17 readily decomposed during NMR measurements, and very

likely changed to 16, yielding a ca. ratio of 3:7. 1D and 2D NMR spectral data of 17 were very

complicated due to a mixture of similar compounds, but it appeared to be a Z-isomer of 16 at

three double bonds C4–C5, C8–C9, and C18–C19, since three couples of tertiary methyl

carbons � 11.0 in 16/22.5 in 17 (4-Me), 12.9 in 16/21.3 in 17 (9-Me), and 13.4 in 16/20.9 in 17

(19-Me) were observed in the HMQC spectrum.

Table S1 1H and 13C NMR data for thailandamide A in CD3OD at 303K

Position 1H ( mult, J Hz) 13C (mult) HMBC correlations (1H to 13C) 1 179.5 (s) 2 2.57 (m) 44.4 (d) C1, C3, 2-Me 3 3.66 (m) 91.0 (d) C1, C2, 2-Me, 3-OMe, 4-Me 4 134.8 (s) 5 6.18 (m) 132.9 (d) C3, 4-Me 6 6.49 (dd 14.5, 11.1) 129.0 (d) C7, C8 7 6.63 (dd 14.5, 11.1) 131.5 (d) 8 6.10 (d 11.1) 131.4 (d) C6, C10, 9-Me 9 137.0 (s) C7, C10, C11, 9-Me 10 6.19 (m) 138.8 (d) C8, C12, 9-Me 11 5.80 (dt 15.4, 7.2) 126.6 (d) C12, C13 12 2.35 (m) 42.1 (d) C10, C11 13 4.15 (m) 69.5 (d) C12, C14 14 2.75 (m) 48.4 (t) 15 201.8 (s) C13, C14, C16, C17 16 6.24 (d 15.1) 130.8 (d) C17 17 7.62 (dd 15.1, 11.8) 140.5 (d) 18 6.19 (m) 129.9 (d) 19-Me 19 146.3 (s) C20, C21, 19-Me 20 6.26 (d 15.7) 134.4 (d) C18, C22, 19-Me 21 5.94 (dd 15.7, 6.0) 136.1 (d) C22, 22-Me 22 4.54 (m) 47.7 (d) C20, C21, 22-Me, 22-NH 23 178.0 (s) C22, C24, C25, 24-Me 24 2.36 (m) 42.3 (d) C25, 24-Me 25 2.08 (m), 2.29 (m) 38.5 (t) C24, C26, C27, 24-Me 26 5.43 (dt 15.2, 6.7) 131.2 (d) C25, C27, C28 27 5.53 (dt 15.2, 6.7) 130.0 (d) C25, C26, C28, C29 28 2.06 (m), 2.12 (m) 41.0 (t) C26, C27, C30 29 3.68 (m) 73.7 (d) C27, C28, C30 30 2.58 (m) 43.4 (t) C32, C36 31 131.3 (s) C30, C33, C36 32, 36 6.98 (d 8.3) 131.5 (d) C30, C32, C36 33, 35 6.69 (d 8.3) 116.1 (d) C32, C33, C35, C36 34 156.7 (s) C32, C33, C35, C36 2-Me 0.94 (d 7.0) 14.7 (q) C2, C3 3-OMe 3.14 (s) 56.5 (q) C3 4-Me 1.67 (s) 11.0 (q) C3, C5 9-Me 1.88 (s) 12.9 (q) C8 19-Me 1.95 (s) 13.4 (q) C19, C20 22-Me 1.24 (d 6.7) 20.8 (q) C21, C22, 22-NH 24-Me 1.09 (d 6.8) 18.0 (q) C24, C25

Supplementary table 1: Identity and deduced substrate specificity of the trans-AT KS domains subjected to phylogenetic analysis

KS clade substrate polyketide source organism

ChiKS3 I α-Me + β-OH chivosazol Sorangium cellulosum

ChiKS14 I α-Me + β-OH chivosazol Sorangium cellulosum

MmpKS8 I α-Me + double bond? mupirocin Pseudomonas fluorescens

MmpKS6 I α-Me + β-OH mupirocin Pseudomonas fluorescens

TaKS12 I α-Me + β-methylene myxovirescin Myxococcus xanthus

DifKS14 I α-Me + β-methylene difficidin Bacillus amyloliquefaciens

TaKS8 I β-branch myxovirescin Myxococcus xanthus

PedKS3 I β-branch pederin Pseudomonas symbiont of Paederus fuscipes

OnnKS3 I β-branch onnamide symbiont of Theonella swinhoei

LnmKS5 I β-keto leinamycin Streptomyces atroolivaceus

DszKS3 I α-dimethyl + β-OH disorazol Sorangium cellulosum

ChiKS4 I α-Me + β-OH chivosazol Sorangium cellulosum

BTKS7 I β-branch (this study) thailandamide Burkholderia thailandensis

BTKS13 I β-branch (this study) thailandamide Burkholderia thailandensis

TaKS6 I β-branch myxovirescin Myxococcus xanthus

BaeKS6 I β-branch bacillaene Bacillus amyloliquefaciens

PedKS7 I α-dimethyl + β-OH pederin Pseudomonas symbiont of Paederus fuscipes

GUKS4 II ?, domain architecture predicts β-OH ? Geobacter uraniumreducens

BTKS2 II β-OH (this study) thailandamide Burkholderia thailandensis

DifKS8 II β-OH difficidin Bacillus amyloliquefaciens

PedKS9 II β-OH (L-configured) pederin Pseudomonas symbiont of Paederus fuscipes

LkcKS5 β-keto lankacidin Streptomyces rochei

BaeKS14 III nonextending KS bacillaene Bacillus amyloliquefaciens

BTKS4 III nonextending KS (this study) thailandamide Burkholderia thailandensis

TaKS3 III nonextending KS myxovirescin Myxococcus xanthus

MmpKS1 III nonextending KS mupirocin Pseudomonas fluorescens

PedKS4 III nonextending KS pederin Pseudomonas symbiont of Paederus fuscipes

OnnKS4 III nonextending KS onnamide symbiont of Theonella swinhoei

LnmKS7 IV ethylene leinamycin Streptomyces atroolivaceus

LkcKS1 IV glycine lankacidin Streptomyces rochei

LkcKS4 IV β-OH (D-configured) lankacidin Streptomyces rochei

ChiKS8 IV β-OH (D-configured) chivosazol Sorangium cellulosum

MlnKS6 IV β-OH (D-configured) macrolactin Bacillus amyloliquefaciens

PedKS8 IV β-pyrane oxygen (D-configured) pederin Pseudomonas symbiont of Paederus fuscipes

DszKS4 IV β-OH (D-configured according to KR sequence)

disorazol Sorangium cellulosum

ChiKS2 IV β-OH (D-configured) chivosazol Sorangium cellulosum

MlnKS3 IV ethylene macrolactin Bacillus amyloliquefaciens

PedKS10 V ? pederin Pseudomonas symbiont of Paederus fuscipes

PedKS11 V ? pederin Pseudomonas symbiont of Paederus fuscipes

GUKS8 V ? ? Geobacter uraniumreducens

BaeKS2 V (E)-double bond bacillaene Bacillus amyloliquefaciens

BaeKS12 V (E)-double bond bacillaene Bacillus amyloliquefaciens

BaeKS11 V (E)-double bond bacillaene Bacillus amyloliquefaciens

DifKS3 V ethylene difficidin Bacillus amyloliquefaciens

DifKS9 V ethylene difficidin Bacillus amyloliquefaciens

TaKS11 V ethylene myxovirescin Myxococcus xanthus

TaKS10 V ethylene or β-keto myxovirescin Myxococcus xanthus

TaKS5 V ethylene myxovirescin Myxococcus xanthus

TaKS9 V ethylene myxovirescin Myxococcus xanthus

MmpKS5 VI acetyl mupirocin Pseudomonas fluorescens

BTKS1 VI p-hydroxyphenylacetyl (this study) thailandamide Burkholderia thailandensis

GUKS1 VI ? ? Geobacter uraniumreducens

PedKS1 VI acetyl pederin Pseudomonas symbiont of Paederus fuscipes

OnnKS1 VI acetyl onnamide symbiont of Theonella swinhoei

ChiKS15 VII (E)-double bond + α-methyl chivosazol Sorangium cellulosum

LnmKS6 VII (E)-double bond + α-methyl leinamycin Streptomyces atroolivaceus

LkcKS2 VII (E)-double bond + α-methyl lankacidin Streptomyces rochei

ChiKS7 VII (E)-double bond chivosazol Sorangium cellulosum

BaeKS9 VII (Z)-double bond + α-methyl bacillaene Bacillus amyloliquefaciens

DifKS7 VII (Z)-double bond + α-methyl difficidin Bacillus amyloliquefaciens

DifKS2 VII (E)-double bond + α-methyl difficidin Bacillus amyloliquefaciens

MlnKS2 VIII β-OH (D-configured) macrolactin Bacillus amyloliquefaciens

TaKS2 VIII β-OH (D-configured) myxovirescin Myxococcus xanthus

BTKS11 VIII β−ΟΗ (τηισ στυδψ) thailandamide Burkholderia thailandensis

PedKS6 VIII β-OH (D-configured) pederin Pseudomonas symbiont of Paederus fuscipes

OnnKS6 VIII β-OH (D-configured) onnamide symbiont of Theonella swinhoei

DifKS4 VIII β-OH difficidin Bacillus amyloliquefaciens

GUKS10 VIII ? ? Geobacter uraniumreducens

TaKS4 VIII β-OH (L-configured) myxovirescin Myxococcus xanthus

MmpKS2 VIII β-OH (D-configured) mupirocin Pseudomonas fluorescens

ChiKS13 IX (Z)-double bond chivosazol Sorangium cellulosum

LkcKS3 IX (E)-double bond lankacidin Streptomyces rochei

LnmKS4 IX (E)-double bond leinamycin Streptomyces atroolivaceus

ChiKS11 IX oxazol π chivosazol Sorangium cellulosum

LnmKS2 IX thiazol π leinamycin Streptomyces atroolivaceus

ChiKS17 IX (E)-double bond chivosazol Sorangium cellulosum

DszKS17 IX (Z)-double bond disorazol Sorangium cellulosum

ChiKS6 IX (E)-double bond chivosazol Sorangium cellulosum

MlnKS10 IX β-OH (after module with inactive DH) macrolactin Bacillus amyloliquefaciens

DifKS11 IX (Z)-double bond difficidin Bacillus amyloliquefaciens

MmpKS7 IX (E)-double bond mupirocin Pseudomonas fluorescens

BTKS3 IX (E)-double bond (this study) thailandamide Burkholderia thailandensis

BTKS14 IX (E)-double bond (this study) thailandamide Burkholderia thailandensis

MmpKS4 IX ? mupirocin Pseudomonas fluorescens

BTKS6 IX (E)-double bond (this study) thailandamide Burkholderia thailandensis

MmpKS3 IX double bond or β-OH? mupirocin Pseudomonas fluorescens

TaKS7 IX (E)-double bond myxovirescin Myxococcus xanthus

BTKS12 IX (E)-double bond (this study) thailandamide Burkholderia thailandensis

DifKS13 IX (E)-double bond difficidin Bacillus amyloliquefaciens

PedKS12 IX double bond? pederin Pseudomonas symbiont of Paederus fuscipes

GUKS5 IX ? ? Geobacter uraniumreducens

BaeKS5 IX (E)-double bond bacillaene Bacillus amyloliquefaciens

GUKS9 IX double bond? ? Geobacter uraniumreducens

GUKS11 IX double bond? ? Geobacter uraniumreducens

MlnKS4 IX (E)-double bond macrolactin Bacillus amyloliquefaciens

MlnKS9 IX (E)-double bond macrolactin Bacillus amyloliquefaciens

MlnKS5 IX (E)-double bond macrolactin Bacillus amyloliquefaciens

MlnKS7 IX β-OH (after module with inactive DH) macrolactin Bacillus amyloliquefaciens

BTKS10 X nonelongating KS, β-keto (this study) thailandamide Burkholderia thailandensis

PedKS13 X nonelongating KS pederin Pseudomonas symbiont of Paederus fuscipes

BaeKS13 X nonelongating KS, α-methylated (E)-double bond

bacillaene Bacillus amyloliquefaciens

DszKS8 X nonelongating KS, (Z)-double bond disorazol Sorangium cellulosum

DszKS10 X nonelongating KS, oxazol disorazol Sorangium cellulosum

ChiKS18 X nonelongating KS, (Z)-double bond chivosazol Sorangium cellulosum

ChiKS9 X nonelongating KS, α-methyl, β-OH chivosazol Sorangium cellulosum

DszKS9 X nonelongating KS, oxazol disorazol Sorangium cellulosum

ChiKS10 X nonelongating KS, oxazol chivosazol Sorangium cellulosum

LnmKS1 X nonelongating KS, thiazol leinamycin Streptomyces atroolivaceus

BTKS9 XI double bond, after module with clade XIV KS (this study)

thailandamide Burkholderia thailandensis

GUKS3 XI double bond, after module with clade XIV KS

? Geobacter uraniumreducens

BaeKS8 XI double bond, after module with clade XIV KS

bacillaene Bacillus amyloliquefaciens

DifKS6 XI double bond, after module with clade XIV KS

difficidin Bacillus amyloliquefaciens

BaeKS4 XI double bond, after module with clade XIV KS

bacillaene Bacillus amyloliquefaciens

DszKS5 XII double bond disorazol Sorangium cellulosum

DszKS6 XII double bond disorazol Sorangium cellulosum

DifKS1 XIII vinyl difficidin Bacillus amyloliquefaciens

DszKS2 XIII propenyl disorazol Sorangium cellulosum

GUKS6 XIV β-OH, nonelongating KS in dehydrating module

? Geobacter uraniumreducens

BTKS8 XIV β-OH, nonelongating KS in dehydrating module (this study)

thailandamide Burkholderia thailandensis

DifKS5 XIV β-OH, nonelongating KS in dehydrating module

difficidin Bacillus amyloliquefaciens

GUKS2 XIV β-OH, nonelongating KS in dehydrating module

? Geobacter uraniumreducens

BaeKS3 XIV β-OH, nonelongating KS in dehydrating module

bacillaene Bacillus amyloliquefaciens

BaeKS7 XIV β-OH, nonelongating KS in dehydrating module

bacillaene Bacillus amyloliquefaciens

LnmKS3 XV double bond generated by module lacking a DH

leinamycin Streptomyces atroolivaceus

ChiKS5 XV double bond generated by module lacking a DH

chivosazol Sorangium cellulosum

MlnKS11 XV double bond generated by module lacking a DH

macrolactin Bacillus amyloliquefaciens

DifKS10 XV double bond generated by module lacking a DH

difficidin Bacillus amyloliquefaciens

MlnKS8 XV double bond generated by module lacking a DH

macrolactin Bacillus amyloliquefaciens

ChiKS12 XV double bond generated by module lacking a DH

chivosazol Sorangium cellulosum

ChiKS16 XV double bond generated by module lacking a DH

chivosazol Sorangium cellulosum

BTKS5 XVI alanine (this study) thailandamide Burkholderia thailandensis

TaKS1 XVI glycine myxovirescin Myxococcus xanthus

BaeKS1 XVI glycine bacillaene Bacillus amyloliquefaciens

BaeKS10 XVI alanine bacillaene Bacillus amyloliquefaciens

PedKS5 XVI glycine pederin Pseudomonas symbiont of Paederus fuscipes

OnnKS5 XVI glycine onnamide symbiont of Theonella swinhoei