SUP-ICUtrial

IntensivsymposiumHindsgavl,2018

SUP-ICU

AnInterna)onalplacebo-controlledRCT

SUP-ICU

•  Popula>on•  Acutelyadmi-edICUpa2entswithhighriskof

stress-relatedGIbleeding

•  Interven>on•  IVPPI(Pantoprazole)

•  Comparator•  IVPlacebo(Saline)

•  Outcome•  90-daymortality

Status

SUP-ICU

Inclusioncompletedon:22October,201790-dayfollow-upcompletedon:20January,2018

Status

SUP-ICU

22months/94weeks/657days

SUP-ICU

Plans

•  Database”cleaning”andmerging(February2018)

•  Sta>s>csandmanuscriptwri>ng(March2018)

•  Submissiontojournal(April2018)

SUP-ICU

PreliminaryResults

SUP-ICU

CONSORT

SUP-ICU

BaselineCharacteris>cs

SUP-ICU

Characteris2c SUP-ICU(n=3291)Age–years 67(55-75)Malegender–no.(%) 2106(64)HoursfromICUadmissiontorandomiza>on 15(5-27)Daysfromhospitaladmissiontorandomiza>on 1(1-3)Emergencysurgeryduringindexhospitaliza>on 1048(32)Elec>vesurgeryduringindexhospitaliza>on 304(9)

BaselineCharacteris>cs

SUP-ICU

Characteris2c SUP-ICU(n=3291)Comorbidi)es–no.(%)

Chroniclungdisease 657(20)Prev.myocardialinfarc>on 298(9)Chronicheartfailure(NYHAIII-IV) 199(5)Useofcor>costeroids 62(2)Hematologicalmalignancy 119(4)Metasta>ccancer 111(3)AIDS 7(0.2)

BaselineCharacteris>cs

SUP-ICU

Characteris2c SUP-ICU(n=3291)RiskfactorsforGIbleeding–no.(%)

Chronicliverdisease 94(3)ChronicRRT 45(1)Coagulopahty 646(20)Useofan>-coagulants 999(30)UseofNSAIDorASA 533(16)Useofintravenousthrombolysis 47(1)Invasivemechanicalven>la>on 2588(79)Vasopressorsorinotropes 2195(67)AcuteRRT -SAPSII -SOFAScore -

PreliminaryOutcomes

SUP-ICU

•  90-daymortality(n=1675) 31%

•  OvertGIbleeding 7%•  Clin.SignGIbleeding 3%•  Nosocomialinfec>on 18%•  Pneumonia(newonset) 16%•  ClostridiumDifficile 2%•  AMI 4%

Acknowledgements

SUP-ICU

Awarmthankyouto…

SUP-ICU

FundedbySupportedby

Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond

Thankyou!

www.sup-icu.com

SUP-ICU