Subject Index–Volume 43

Archives of Medical Research 44 (2013) e7ee16

SUBJECT INDEX–VOLUME 43

AABCB1 C3435T polymorphism, role in platinum-based

therapy, 329e331Acoustic trauma, acute, in guinea pigs, effects of carbogen

on cochlear blood flow and hearing functionfollowing, 530e535

-444A/C polymorphism, in the LTC4S gene and the risk ofasthma, 444e450

ACS. See Acute coronary syndromeAcute coronary syndrome (ACS), interaction between endo-

thelial nitric oxide synthase gene polymorphisms(-786T-C and 894G-T) and intron 4 a/b and cardio-vascular risk factors in, 205e211

Acute myocardial infarction (AMI), and stable anginacorrelates with platelet activation, number of micro-particles generated during, 31e35

Adiponectin, and gene variability in obesity and metabolicsyndrome in young population, 145e153

Adipose tissue, human, lipoaspirated, stem cells derivedfrom, in vitro generation of functional insulin-producing cells from, 83e88

Adriamycin, by targeting Notch1, role of microRNA-34a inchemosensitivity of breast cancer cells to, 514e521

Aging, human plasma PON1 arylesterase activity during,438e443

Airflow obstruction, in never smokers in five Latin Americancities, 169e175

Alanine aminotransferase (ALT), elevated, in South TexasMexican-American population, population-basedrisk factors for, 482e488

Alkaline phosphatase, gene, tissue-nonspecific, in twoChinese families with hypophosphatasia, identifica-tion of mutations in, 21e30

ALT. See Alanine aminotransferaseAlzheimer’s diseaseclinical diagnosis in preclinical stage of, 667e670critical history of, 595e599and dementia, epidemiology of, 600e608deregulated Cdk5 activity is involved in inducing, 655e662and Down syndrome, role of tau protein in neuronal

damage in, 645e654early-onset, nonamnestic subtypes of, 677e685emerging noninvasive biomarkers for early detection of,

663e666genetics of, 622e631molecular, biological and clinical aspects of, 593e594neuropsychology of, 686e693

0188-4409/$ - see front matter. Copyright � 2013 IMSS. Published by Elsevierhttp://dx.doi.org/10.1016/S0188-4409(13)00030-1

oxidative stress, neuroinflammation, and connexin-basedcommunication as a risk factors for, 632e644

pathogenesis and disease-modifying therapy in, 694e698physical activity, and brain plasticity, epidemiological

studies examining the association between,615e621

therapeutic role of shilajit and vitamin B complex forprevention of, 699e704

and vascular dementia, contribution of neuroimaging tothe diagnosis of, 671e676

AMI. See Acute myocardial infarctionAmino acids

in CHO-K1 cells, insulin signaling pathway involved inglucose uptake mediated by, 173e182

in elderly women with mild depression, plasma levels of,375e382

Angina, stable, and AMI, correlates with platelet activation,number of microparticles generated during, 31e35

Antidepressants, effect on elevated serum ceruloplasminlevel in patients with first-episode depression,294e297

Antimicrobial acitvity, of Helicobacter pylori, detection ofphytoconstituents in column fractions of n-hexaneextract of Goldcrest honey as, 197e204

Antioxidants, status, and lipid levels in rat brain, effect ofacute ELF-EMF on, 183e189

Apoptosisof cell, and doublecortin and reelin protein expression in

rat cerebellum, perinatal iodine deficiency andhypothyroidism increase the, 255e264

and chemoresistance, in MIA PaCa-2 pancreatic cancercells, Bcl-2 upregulation induced by miR-21 viadirect interaction associated with, 252e253

HBEpC, likely via regulating the activity of PERK-eI-F2a signaling pathway, salubrinal protects againstcigarette smoke extract-induced, 522e529

trichostatin A ameliorates myocardial ischemia/reperfu-sion injury through inhibition of endoplasmic retic-ulum stress-induced, 190e196

Asthmae444A/C polymorphism in the LTC4S gene and the risk

of, 444e450atopic, serum chemokines RANTES and MCP-1 in Egyp-

tian patients with, 36e41Atherogenesis, is associated with cellular oxidative stress

triggered by activation of scavenger receptors, os-teopontin upregulation in, 102e111

Inc.

http://dx.doi.org/10.1016/S0188-4409(13)00030-1

http://dx.doi.org/10.1016/S0188-4409(13)00030-1

e8 Subject Index/ Archives of Medical Research 44 (2013) e7ee16

ATP-sensitive potassium (KATP) channel, on type 2 diabetesin Turkish population, effects of SNPs in, 317e323

Auditory neuropathy, hearing loss, and neurological co-morbidity in children with birthweight !750 g,457e463

BBand 3 protein, distortion of b-globin chain of hemoglobin

alters the pathway of erythrocytic glucose metabo-lism through, 112e116

B-cell acute lymphoblastic leukemia (B-ALL), earlylymphoid development and microenvironmentalcues in, 89e101

B-cell lymphoma 2 (Bcl-2), upregulation induced by miR-21 via direct interaction associated with apoptosisand chemoresistance in MIA PaCa-2 pancreaticcancer cells, 252e253

Bcl-2. See B-cell lymphoma 2Benzene, toluene-xylene, production of IL-10, TNF and

IL-12 by PBMCs in Mexican workers exposed toa mixture of, 51e57

B-globin, chain of hemoglobin alters the pathway of eryth-rocytic glucose metabolism through band 3 protein,distortion of, 112e116

Blood flow, cochlear, and hearing function following acuteacoustic trauma in guinea pigs, effects of carbogenon, 530e535

BMD. See Bone mineral densityBody mass index, and BMD, association study of sirtuin 1

polymorphisms with, 363e368Bone mass, and Wnt/b-catenin signaling pathway in ovari-

ectomized rats, effects of PEMFs on, 274e282Bone mineral density (BMD), and body mass index, asso-

ciation study of sirtuin 1 polymorphisms with,363e368

Brain, of rat, effect of acute ELF-EMF on antioxidant statusand lipid levels in, 183e189

Brain plasticity, physical activity, and Alzheimer’s disease,epidemiological studies examining the associationbetween, 615e621

Breast cancerassociation of STXBP4/COX11 rs6504950 (GOA) poly-

morphism and risk of, 383e388cells to adriamycin by targeting Notch1, role of micro-

RNA-34a in chemosensitivity of, 514e521invasive, effectiveness of silver-enhanced in situ hybrid-

ization for evaluating HER2 gene status in, 139e144using siRNA (E2F3)-based gene silencing, overexpres-

sion of E2F3 in, 415e422Breast carcinoma. See Breast cancerBreast tumor, benign and malignant, evaluation of PDE5

and PDE9 expression in, 470e475Bs-globin, impact on oxidative stress in patients with SCA

in steady state, 536e540

CCAD. See Coronary artery diseaseCalcium

induced cardiac mitochondrial dysfunction is predomi-nantly mediated by cyclosporine A-dependent mito-chondrial permeability transition pore, 333e338

mobilization in pulmonary artery smooth muscle cellsfrom hypoxic pulmonary hypertensive mice, varde-nafil ameliorates the, 265e273

Cancer, gastrointestinal, upper, PLC-e1 gene polymor-phisms significantly enhance the risk of esophagealsquamous cell carcinoma in individuals with familyhistory of, 578e584

Captopril, disulfiram and nelfinavir, a trio of old drugs andMMP 2 and 9, as adjunctive treatments in glioblas-toma, 243e247

Carbogen, effects on cochlear blood flow and hearing func-tion following acute acoustic trauma in guinea pigs,530e535

Cardiac mitochondrial dysfunction, induced by calcium, ispredominantly mediated by cyclosporine A-dependentmitochondrial permeability transition pore, 333e338

Cardiovascular disease, and renal function deterioration inadvanced chronic kidney disease, indoxyl sulfatepredicts the, 451e456

Cardiovascular risk factors, and endothelial nitric oxidesynthase gene polymorphisms (-786T-C and 894G-T) and intron 4 a/b, in ACS, interaction between,205e211

Carpal tunnel syndrome, and fibromyalgia, evaluation ofupper extremity nerve conduction velocities andthe relationship between, 369e374

Catechol-O-methyltransferase (COMT), gene and risk ofpreeclampsia in Chinese population, associationbetween Val158Met functional polymorphism in,154e158

Caucasians, contribution of NAD(P)H quinone oxidoreduc-tase 1 Pro187Ser polymorphism and risk of colo-rectal adenoma and colorectal cancer in, 58e66

Ccf mtDNA. See Circulating cell-free mitochondrial DNACdk5. See Cyclin-dependent kinaseCerebellum, of rat, perinatal iodine deficiency and hypothy-

roidism increase cell apoptosis and alter doublecortinand reelin protein expressions in, 255e264

Ceruloplasmin, elevated serum level in patients with first-episode depression, effect of antidepressant treat-ment on, 294e297

Chemokines RANTES, serum, and MCP-1, in Egyptianpatients with atopic asthma, 36e41

Chemoresistance, and apoptosis, in MIA PaCa-2 pancreaticcancer cells, Bcl-2 upregulation induced by miR-21via direct interaction associated with, 252e253

Childrenwith birthweight !750 g, hearing loss, auditory neurop-

athy, and neurological co-morbidity in, 457e463

e9Subject Index/ Archives of Medical Research 44 (2013) e7ee16

and maternal seroprevalence of antibodies against Trepo-nema pallidum at four general hospitals in the stateof Morelos Mexico, 571e577

of Mexican, immunogenicity of a 23-valent pneumo-coccal polysaccharide vaccine among, 402e405

Chineseassociation between PPARg, and RXR-a gene polymor-

phisms and metabolic syndrome in, 159e168association between Val158Met functional polymor-

phism in COMT gene and risk of preeclampsia in,154e158

C677T polymorphism, in MTHFR gene a risk factor fordiabetic nephropathy or diabetes mellitus in,42e50, 176e179, 248e251

two families with hypophosphatasia, identification ofmutations in tissue-nonspecific alkaline phosphatasegene in, 21e30

two unrelated families, with dRTA, identification of twonovel mutations in SLC4A1 gene in, 298e304

CHO-K1 cells, insulin signaling pathway involved in glucoseuptake mediated by amino acids in, 173e182

Cigarette smoke extract, induced HBEpC apoptosis likelyvia regulating the activity of PERK-eIF2a signalingpathway, salubrinal protects against, 522e529

Circulating cell-free mitochondrial DNA (ccf mtDNA),quantification in patients with Ewing’s sarcoma,389e394

Clopidogrel, and proton pump inhibitors, in patients withCAD, adverse cardiovascular effects of concomitantuse of, 212e224

Cochlear, blood flow, and hearing function following acuteacoustic trauma in guinea pigs, effects of carbogenon, 530e535

Colorectal adenoma, and colorectal cancer in Caucasians,contribution of NAD(P)H quinone oxidoreductase1 Pro187Ser polymorphism and risk of, 58e66

Colorectal cancer, and colorectal adenoma, in Caucasians,contribution of NAD(P)H quinone oxidoreductase1 Pro187Ser polymorphism and risk of, 58e66

Computed tomography (CT), in diagnosis of mediastinaland hilar lymph node metastasis of NSCLC, LMVDcombined with, 132e138

COMT. See Catechol-O-methyltransferaseConnexin, based communication, oxidative stress, and neu-

roinflammation, as a risk factors for Alzheimer’sdisease, 632e644

Coronary artery disease (CAD), adverse cardiovasculareffects of concomitant use of proton pump inhibi-tors and clopidogrel in patients with, 212e224

Craniopharyngiomain adults, classification systems of, 588e591in adults, treatment of, 347e355

C677T polymorphismof MTHFR, association with risk of myocardial infarc-

tion, 489e490

in MTHFR gene a risk factor for diabetic nephropathy ordiabetes mellitus in Chinese population, 42e50,176e179, 248e251

1858C/T polymorphism, of protein tyrosine phosphatasenonreceptor 22 gene, and rheumatoid arthritis riskin Europeans, 180e182

Cyclin-dependent kinase (Cdk5), activity is involved ininducing Alzheimer’s disease, 655e662

Cyclosporine, dependent mitochondrial permeability transi-tion pore, calcium induced cardiac mitochondrialdysfunction is predominantly mediated by,333e338

CYP3A5 polymorphism, in Mexican renal transplant recip-ients and its association with tacrolimus dosing,283e287

DDefensin 2, beta, expression in experimental pulmonary

tuberculosis a tentative approach for vaccine devel-opment, 324e328

Dementiaand Alzheimer’s disease, epidemiology of, 600e608macroeconomics of, 705e709vascular, and Alzheimer’s disease, contribution of neuro-

imaging to the diagnosis of, 671e676Depression

first-episode, effect of antidepressant treatment onelevated serum ceruloplasmin level in patients with,294e297

mild, plasma levels of amino acids in elderly womenwith, 375e382

Diabetes mellitusor diabetic nephropathy, in Chinese population, C677T

polymorphism in MTHFR gene a risk factor for,42e50, 176e179, 248e251

type 2association between IGF2BP2 rs4402960 polymor-

phism and risk of, 411e413DNA and oxidative damages decrease after ingestion

of folic acid in patients with, 476e481lower serum paraoxonase-1 activity is related to lino-

leic and docosahexanoic fatty acids in, 75e82in Turkish population, effects of SNPs in KATP channel

genes on, 317e323Diabetic nephropathy, or diabetes mellitus in Chinese pop-

ulation, C677T polymorphism in MTHFR genea risk factor for, 42e50, 176e179, 248e251

Disease-modifying therapy, and pathogenesis in Alz-heimer’s disease, 694e698

Distal renal tubular acidosis (dRTA), identification of twonovel mutations in SLC4A1 gene in two unrelatedChinese families with, 298e304

Disulfiram, captopril, and nelfinavir, a trio of old drugs andMMP 2 and 9, as adjunctive treatments in glioblas-toma, 243e247


DNA, and oxidative damages decrease after ingestionof folic acid in patients with type 2 diabetes,476e481

Docosahexanoic fatty acids, and linoleic, in type 2 diabetesmellitus, lower serum paraoxonase-1 activity isrelated to, 75e82

Down syndrome, and Alzheimer’s disease, role of tauprotein in neuronal damage in, 645e654

DRTA. See Distal renal tubular acidosis

EE2F transcription factor 3 (E2F3), in breast cancer using

siRNA (E2F3)-based gene silencing, overexpressionof, 415e422

Egypt, serum chemokines RANTES and MCP-1 in patientswith atopic asthma in, 36e41

Elderly, women, with mild depression, plasma levels ofamino acids in, 375e382

ELF-EMF. See Extremely low frequency electromagneticfields

Embryonic stem cell, and induced pluripotent stem cells,therapeutic potential of motor neurons differentia-tion from, 1e10

Endoplasmic reticulum stress, induced apoptosis, trichosta-tin A ameliorates myocardial ischemia/reperfusioninjury through inhibition of, 190e196

Endothelial cells, human, under different levels of hypoxia,alteration of telomere length and subtelomericmethylation in, 15e20

Endothelial nitric oxide synthase, gene polymorphisms(-786T-C and 894G-T) and intron 4 a/b, and cardio-vascular risk factors in ACS, interaction between,205e211

Erythrocytes, glucose metabolism through band 3 protein,distortion of b-globin chain of hemoglobin altersthe pathway of, 112e116

Esophageal squamous cell carcinoma, in individuals withfamily history of upper gastrointestinal cancer,PLC-e1 gene polymorphisms significantly enhancethe risk of, 578e584

Europe, 1858 C/T polymorphism of protein tyrosine phospha-tase nonreceptor 22 gene, and rheumatoid arthritis riskin, 180e182

Ewing’s sarcoma, quantification of ccf mtDNA in patientswith, 389e394

Exercise, maximal, intermittent, improves attentionalperformance in physically active students,125e131

Extracellular matrix metalloproteinases, remodeling in Ta-kayasu’s arteritis, 406e410

Extremely low frequency electromagnetic fields (ELF-EMF), acute, effect on antioxidant status and lipidlevels in rat brain, 183e189

FFibromyalgia, and carpal tunnel syndrome, evaluation of

upper extremity nerve conduction velocities andthe relationship between, 369e374

Folic acid, in patients with type 2 diabetes, DNA and oxida-tive damages decrease after ingestion of, 476e481

Framingham risk score (FRS), and serum total bilirubinconcentration, in Korean population, associationbetween, 288e293

FRS. See Framingham risk score

GGastric cardiac adenocarcinoma, in nonsmokers, ERCC1

+262A/C polymorphism associated with risk of,67e74

Gastrointestinal cancer, upper, PLC-e1 gene polymor-phisms significantly enhance the risk of esophagealsquamous cell carcinoma in individuals with familyhistory of, 578e584

Genetics, of Alzheimer’s disease, 622e631Ghrelin, serum level, and TNF-a/ghrelin ratio in patients

with previous myocardial infarction, 548e554Glioblastoma, MMP 2 and 9 and a trio of old drugs capto-

pril, disulfiram and nelfinavir as adjunctive treat-ments in, 243e247

Glucose, uptake mediated by amino acids in CHO-K1 cells,insulin signaling pathway involved in, 173e182

Glucose metabolism, erythrocytic, through band 3 protein,distortion of b-globin chain of hemoglobin altersthe pathway of, 112e116

Glucose transporter protein-1 (Glut-1), antisense, effect onthe expression of MMP-2, MT-MMP in laryngealcarcinoma Hep-2 cell line by, 395e401

Glut-1. See Glucose transporter protein-1Glutathione peroxidase 3, in overweight and obese subjects

from central Mexico, serum levels of, 541e547Guinea pigs, effects of carbogen on cochlear blood flow and

hearing function following acute acoustic trauma in,530e535

HHBEpC. See Human bronchial epithelial cellsHCV-NS4. See Hepatitis C virus-NS4Hearing function, and cochlear blood flow, following acute

acoustic trauma in guinea pigs, effects of carbogenon, 530e535

Hearing loss, auditory neuropathy, and neurological co-morbidity in children with birthweight !750 g,457e463

Helicobacter pyloriactivity of, detection of phytoconstituents in column

fractions of n-hexane extract of Goldcrest honeyas, 197e204


and iceA1 and iceA2 genes in Mexican isolates,339e346

Hemoglobin, alters the pathway of erythrocytic glucosemetabolism through band 3 protein, distortion ofb-globin chain of, 112e116

Hepatitis C virus-NS4 (HCV-NS4), antigen in patients withliver disease, diagnostic performances of, 555e562

Hep-2 cell line, laryngeal carcinoma, by antisense Glut-1,effect on the expression of MMP-2, MT-MMP in,395e401

HER2 gene, status in invasive breast carcinoma, effective-ness of silver-enhanced in situ hybridization forevaluation of, 139e144

Honey, Goldcrest, anti-Helicobacter pylori activity, detec-tion of phytoconstituents in column fractions of n-hexane extract of, 197e204

Human bronchial epithelial cells (HBEpC), apoptosis,likely via regulating the activity of PERK-eIF2asignaling pathway, salubrinal protects against ciga-rette smoke extract-induced, 522e529

Human germline genetic modification, scientific and bioeth-ical perspectives of, 491e513

Hypophosphatasia, identification of mutations in tissue-nonspecific alkaline phosphatase gene in twoChinese families with, 21e30

Hypothyroidism, and perinatal iodine deficiency increasecell apoptosis and alter doublecortin and reelinprotein expressions in rat cerebellum, 255e264

Hypoxia, alteration of telomere length and subtelomericmethylation in human endothelial cell underdifferent levels of, 15e20

IIgE. See Immunoglobulin EIL-10. See Interleukin-10IL-12. See Interleukin-12Immune response, to seasonal influenza A virus (H1N1)

infection, 464e469Immunogenicity, of a 23-valent pneumococcal polysaccha-

ride vaccine among Mexican children, 402e405Immunoglobulin E (IgE), prominent response, patients

exposed to Mycobacterium tuberculosis infectionwith, 225e232

India, north, association of polymorphisms in MMP2 andTIMP2 with prostate cancer susceptibility in, 117e124

Indoxyl sulfate, predicts cardiovascular disease and renalfunction deterioration in advanced chronic kidneydisease, 451e456

Influenza A virus (H1N1)infection, seasonal, immune response to, 464e469pandemic, in Mexico, epidemiological characterization

of fourth wave of, 563e570Insulin, signaling pathways, involved in glucose uptake

mediated by amino acids in CHO-K1 cells, 173e182

Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2), rs4402960 polymorphism, associatedwith risk of type 2 diabetes mellitus, 411e413

Insulin-producing cells, functional, from lipoaspiratedhuman adipose tissue-derived stem cells, in vitrogeneration of, 83e88

Intellectual disability, next generation sequencing revealsa novel intragenic deletion of TPO gene in a familywith, 312e316

Interleukin-10 (IL-10), TNF and IL-12, by PBMCs inMexican workers exposed to a mixture ofbenzene-toluene-xylene, production of, 51e57

Interleukin-12 (IL-12), TNF and IL-10, by PBMCs inMexican workers exposed to a mixture ofbenzene-toluene-xylene, production of, 51e57

Internal mammary artery, human, role of TRPC3 in,431e437

Iodine deficiency disorders, perinatal, and hypothyroidism,increase cell apoptosis and alter doublecortin andreelin protein expressions in rat cerebellum,255e264

Ischemia/reperfusion injury, myocardial, through inhibitionof endoplasmic reticulum stress-induced apoptosis,trichostatin A ameliorates, 190e196

KKATP channel. See ATP-sensitive potassiumKidney disease, chronic, advanced, indoxyl sulfate predicts

cardiovascular disease and renal function deteriora-tion in, 451e456

Korean, population, association between serum total bili-rubin concentration and FRS in, 288e293

LLaryngeal carcinoma, Hep-2 cell line by antisense Glut-1,

effect on the expression of MMP-2, MT-MMP in,395e401

Leukotriene C4 synthase (LTC4S) gene, and the risk ofasthma, e444A/C polymorphism in, 444e450

Linoleic acid, and docosahexanoic fatty acids, in type 2 dia-betes mellitus, lower serum paraoxonase-1 activityis related to, 75e82

Lipids, level of, and antioxidants status, in rat brain, effectof acute ELF-EMF on, 183e189

Lipoprotein-associated phospholipase A2 (Lp-PLA2), isinversely correlated with PCSK9, 11e14

Liver diseasediagnostic performances of HCV-NS4 antigen in patients

with, 555e562end-stage, by regulating the Notch signaling pathway,

possibility of the enhanced progression of fetal liverstem/progenitor cells therapy for treatment of,585e587

LMVD. See Lymphatic microvessel density


Lp-PLA2. See Lipoprotein-associated phospholipase A2

LTC4S. See Leukotriene C4 synthaseLymphatic microvessel density (LMVD), combined with

CT in diagnosis of mediastinal and hilar lymph nodemetastasis of NSCLC, 132e138

Lymph node metastasis, hilar, and mediastinal, of NSCLC,LMVD combined with CT in diagnosis of, 132e138

Lymphoid system, early development, and microenviron-mental cues in B-ALL, 89e101

MMatrix metalloproteinase-2 (MMP-2)

MMP 9, and a trio of old drugs captopril, disulfiram andnelfinavir as adjunctive treatments in glioblastoma,243e247

MT-MMP in laryngeal carcinoma Hep-2 cell line byantisense Glut-1, effect on the expression of,395e401

and TIMP2, with prostate cancer susceptibility in NorthIndia, association of polymorphisms in, 117e124

Matrix metalloproteinase-9 (MMP-9), MMP 2, and a trio ofold drugs captopril, disulfiram and nelfinavir asadjunctive treatments in glioblastoma, 243e247

MCP-1. See Monocyte chemoattractant protein-1Membrane type 1-matrix metalloproteinases (MT-MMP),

MMP-2, in laryngeal carcinoma Hep-2 cell line byantisense Glut-1, effect on the expression of,395e401

Metabolic syndromeand obesity, in young population, adiponectin level and

gene variability in, 145e153and PPARg, and RXR-a gene polymorphisms in Chinese

population, association between, 159e168risk, and PPARg and RXR-a gene polymorphism, asso-

ciation between, 233e242Methylenetetrahydrofolate reductase (MTHFR)

gene a risk factor for diabetic nephropathy or diabetesmellitus in Chinese population, C677T polymor-phism in, 42e50, 176e179, 248e251

and risk of myocardial infarction, association betweenC677T polymorphism of, 489e490

Mexicanchildren, immunogenicity of a 23-valent pneumococcal

polysaccharide vaccine among, 402e405isolates, Helicobacter pylori, and iceA1 and iceA2 genes

in, 339e346renal transplant recipients and its association with tacro-

limus dosing, CYP3A5 polymorphism in, 283e287workers exposed to a mixture of benzene-toluene-xylene,

production of IL-10, TNF and IL-12 by PBMCs in,51e57

Mexican-Americans, South Texas, population-based riskfactors for elevated ALT in, 482e488

Mexico

central, serum levels of glutathione peroxidase 3 in over-weight and obese subjects from, 541e547

epidemiological characterization of fourth wave ofpandemic H1N1 influenza in, 563e570

Morelos, maternal/child seroprevalence of antibodiesagainst Treponema pallidum at four general hospi-tals in the state of, 571e577

Microcapillary culture method, for in vitro expansion ofstem cells from scarce sources, 423e430

Microparticles, generated during AMI and stable anginacorrelates with platelet activation, number of, 31e35

MicroRNA-21, Bcl-2 upregulation induced via direct inter-action associated with apoptosis and chemoresist-ance in MIA PaCa-2 pancreatic cancer cells by,252e253

MicroRNA-34a, role in chemosensitivity of breast cancercells to adriamycin by targeting Notch1, 514e521

Mild cognitive impairment, detection and diagnosis,609e614

Mitochondrial permeability transition, cyclosporine A-dependent, calcium induced cardiac mitochondrialdysfunction is predominantly mediated by, 333e338

MMP-2. See Matrix metalloproteinase-2MMP-9. See Matrix metalloproteinase-9Monocyte chemoattractant protein-1 (MCP-1), and serum

chemokines RANTES, in Egyptian patients withatopic asthma, 36e41

Morbidity, neurological, hearing loss, and auditory neurop-athy, in children with birthweight !750 g, 457e463

Motor neurons, differentiation from embryonic stem celland induced pluripotent stem cells, therapeuticpotential of, 1e10

MTHFR. See Methylenetetrahydrofolate reductaseMutation

identification in tissue-nonspecific alkaline phosphatasegene in two Chinese families with hypophosphata-sia, 21e30

in SLC4A1 gene in two unrelated Chinese families withdRTA, identification of, 298e304

Mycobacterium tuberculosis infection, with prominent IgEresponse, patients exposed to, 225e232

Myocardial infarction (MI)association between MTHFR C677T polymorphism and

risk of, 489e490previous, serum ghrelin level and TNF-a/ghrelin ratio in

patients with, 548e554

NNelfinavir, captopril, and disulfiram, a trio of old drugs and

MMP 2 and 9, as adjunctive treatments in glioblas-toma, 243e247

Nerve conduction velocities, upper extremity, and the rela-tionship between fibromyalgia and carpal tunnelsyndrome, evaluation of, 369e374


Neuroinflammation, oxidative stress, and connexin-basedcommunication as a risk factors for Alzheimer’sdisease, 632e644

Neuronal damage, in Down syndrome and Alzheimer’sdisease, role of tau protein in, 645e654

Neuropsychology, of Alzheimer’s disease, 686e693Next generation sequencing, reveals a novel intragenic

deletion of TPO gene in a family with intellectualdisability, 312e316

Non-small cell lung cancer (NSCLC), LMVD combinedwith CT in diagnosis of mediastinal and hilar lymphnode metastasis of, 132e138

Nonsmokers, ERCC1 +262A/C polymorphism associatedwith risk of gastric cardiac adenocarcinoma in,67e74

OObesityand metabolic syndrome, in young population, adiponec-

tin level and gene variability in, 145e153and overweight, subjects from central Mexico, serum

levels of glutathione peroxidase 3 in, 541e547Omega-3 polyunsaturated fatty acids, effects in rheumatoid

arthritis, 356e362Osteopontin, upregulation in atherogenesis is associated

with cellular oxidative stress triggered by activationof scavenger receptors, 102e111

Overweight, and obese subjects from central Mexico, serumlevels of glutathione peroxidase 3 in, 541e547

Oxidative damage, and DNA decrease after ingestion offolic acid in patients with type 2 diabetes, 476e481

Oxidative stresscellular, triggered by activation of scavenger receptors,

osteopontin upregulation in atherogenesis is associ-ated with, 102e111

neuroinflammation, and connexin-based communicationas a risk factors for Alzheimer’s disease, 632e644

in patients with SCA in steady state, impact of bs-globinhaplotypes on, 536e540

PPancreatic cancer cells, MIA PaCa-2, Bcl-2 upregulation

induced by miR-21 via direct interaction associatedwith apoptosis and chemoresistance in, 252e253

Pandemics, influenza H1N1, in Mexico, epidemiologicalcharacterization of fourth wave of, 563e570

Paraoxonase 1 (PON1), human, arylesterase activity duringaging, 438e443

PBMCs. See Peripheral blood mononuclear cellsPEMFs. See Pulsed electromagnetic fieldsPeripheral blood mononuclear cells (PBMCs), in Mexican

workers exposed to a mixture of benzene-toluene-xylene, production of IL-10, TNF and IL-12 by,51e57

Peroxisome proliferator-activated receptor-g (PPARg)and RXR-a gene polymorphism and metabolic syndrome

in Chinese population, association between, 159e168and RXR-a gene polymorphism and metabolic syndrome

risk, association between, 233e242Phosphodiesterases (PDE), 5 and 9, expression in benign

and malignant breast tumor, evaluation of, 470e475Phospholipase C epsilon 1 (PLCe1), gene polymorphisms

significantly enhance the risk of esophageal squa-mous cell carcinoma in individuals with familyhistory of upper gastrointestinal cancer, 578e584

Physical activity, Alzheimer’s disease, and brain plasticity,epidemiological studies examining the associationbetween, 615e621

Phytoconstituents, in column fractions of n-hexane extractof Goldcrest honey as antibacterial activity of Heli-cobacter pylori, detection of, 197e204

Platelet activation, number of microparticles generatedduring AMI and stable angina correlates with,31e35

Platinum-based therapy, role of ABCB1 C3435T polymor-phism in, 329e331

PLCe1. See Phospholipase C epsilon 1Pluripotent stem cell, induced, and embryonic stem cell,

therapeutic potential of motor neurons differentia-tion from, 1e10

Pneumococcal vaccine, a 23-valent polysaccharide, amongMexican children, immunogenicity of, 402e405

PolymorphismsABCB1 C3435T, role in platinum-based therapy,

329e331-444A/C, in the LTC4S gene and the risk of asthma,

444e450C677T, in MTHFR gene a risk factor for diabetic

nephropathy or diabetes mellitus in Chinese popula-tion, 42e50, 176e179, 248e251

1858 C/T, of protein tyrosine phosphatase nonreceptor 22gene, and rheumatoid arthritis risk in Europeans,180e182

C677T of MTHFR, association with risk of myocardialinfarction, 489e490

CYP3A5, in Mexican renal transplant recipients and itsassociation with tacrolimus dosing, 283e287

endothelial nitric oxide synthase gene (-786T-C and894G-T) and intron 4 a/b, and cardiovascular riskfactors in ACS, interaction between, 205e211

ERCC1 +262A/C, associated with risk of gastric cardiacadenocarcinoma in nonsmokers, 67e74

IGF2BP2 rs4402960, associated with risk of type 2 dia-betes mellitus, 411e413

in MMP2 and TIMP2 with prostate cancer susceptibilityin North India, association of, 117e124

PLCe1 gene, significantly enhance the risk of esophagealsquamous cell carcinoma in individuals with familyhistory of upper gastrointestinal cancer, 578e584


PPARg, and RXR-a, and metabolic syndrome in Chinesepopulation, association between, 159e168

PPARg and RXR-a gene, and metabolic syndrome risk,association between, 233e242

Pro187Ser, NAD(P)H quinone oxidoreductase 1, and riskof colorectal adenoma and colorectal cancer inCaucasians, contribution of, 58e66

Sirtuin 1, with BMD and body mass index, associationstudy of, 363e368

STXBP4/COX11 rs6504950 (GOA), and risk of breastcancer, association of, 383e388

Val158Met, in COMT gene and risk of preeclampsia inChinese population, association between, 154e158

PON1. See Paraoxonase 1PPARg. See Peroxisome proliferator activated receptor-gPreeclampsia, in Chinese population, association between

Val158Met functional polymorphism in COMTgene and risk of, 154e158

Proprotein convertase subtilisin-kexin type 9 (PCSK9), Lp-PLA2 is inversely correlated with, 11e14

Pro187Ser polymorphism, NAD(P)H quinone oxidoreduc-tase 1, and risk of colorectal adenoma and colorectalcancer in Caucasians, contribution of, 58e66

Prostate cancer, susceptibility in North India, associationof polymorphisms in MMP2 and TIMP2 with,117e124

Protein expression, doublecortin and reelin, and cellapoptosis, in rat cerebellum, perinatal iodine defi-ciency and hypothyroidism increase the, 255e264

Protein tyrosine phosphatase, nonreceptor 22 gene, 1858 C/T polymorphism of, and rheumatoid arthritis risk inEuropeans, 180e182

Proton pump inhibitors, and clopidogrel, in patients withCAD, adverse cardiovascular effects of concomitantuse of, 212e224

Pulmonary artery smooth muscle cells, from hypoxicpulmonary hypertensive mice, vardenafil amelio-rates calcium mobilization in, 265e273

Pulmonary hypertension, hypoxic, mice, vardenafil amelio-rates calcium mobilization in pulmonary arterysmooth muscle cells from, 265e273

Pulmonary tuberculosis, experimental, a tentative approachfor vaccine development, expression of beta defen-sin 2 in, 324e328

Pulsed electromagnetic fields (PEMFs), effects on bonemass and Wnt/b-catenin signaling pathway in ovari-ectomized rats, 274e282

QQuinone oxidoreductase 1, NAD(P)H, Pro187Ser poly-

morphism and risk of colorectal adenoma andcolorectal cancer in Caucasians, contribution of,58e66

RRats, effect of acute ELF-EMF on antioxidant status and

lipid levels in brain of, 183e189Rectal cancer, thrombocytosis as predictor of distant recur-

rence in patients with, 305e311Renal function, deterioration, and cardiovascular disease, in

advanced chronic kidney disease, indoxyl sulfatepredicts the, 451e456

Renal transplantation, Mexican recipients, and its associa-tion with tacrolimus dosing, CYP3A5 polymor-phism in, 283e287

Retinoic acid receptor-a(RXR-a), and PPARg, gene poly-morphism and metabolic syndrome in Chinese pop-ulation, association between, 159e168

Retinoid X receptor-a (RXR-a), and PPARg, gene poly-morphism and metabolic syndrome risk, associationbetween, 233e242

Rheumatoid arthritiseffect of omega-3 polyunsaturated fatty acids in,

356e362in Europeans, 1858 C/T polymorphism of protein tyro-

sine phosphatase nonreceptor 22 gene and risk of,180e182

Risk factorsfor Alzheimer’s disease, oxidative stress, neuroinflamma-

tion, and connexin-based communication as, 632e644and COMT gene, of preeclampsia in Chinese population,

association between Val158Met functional poly-morphism in, 154e158

for diabetic nephropathy or diabetes mellitus in Chinesepopulation, C677T polymorphism in MTHFR gene,42e50, 176e179, 248e251

population-based, for elevated ALT in South Texas Mex-icaneAmerican population, 482e488

RXR-a. See Retinoic acid receptor-a

SSalubrinal, protects against cigarette smoke extract-induced

HBEpC apoptosis likely via regulating the activityof PERK-eIF2a signaling pathway, 522e529

SCA. See Sickle cell anemiaScavenger receptors, osteopontin upregulation in athero-

genesis is associated with cellular oxidative stresstriggered by activation of, 102e111

Serum Paraoxonase-1, lower, activity is related to linoleicand docosahexanoic fatty acids in type 2 diabetesmellitus, 75e82

Shilajit, and vitamin B complex, for prevention of Alz-heimer’s disease, therapeutic role of, 699e704

Sickle cell anemia (SCA), in steady state, impact of bs-globin haplotypes on oxidative stress in patientswith, 536e540

Signaling pathways


insulin, involved in glucose uptake mediated by aminoacids in CHO-K1 cells, 173e182

Notch, possibility of the enhanced progression of fetalliver stem/progenitor cells therapy for treatment ofend-stage liver diseases by regulating the, 585e587

PERK-eIF2a, salubrinal protects against cigarette smokeextract-induced HBEpC apoptosis likely via regu-lating the activity of, 522e529

Wnt/b-catenin, and bone mass, in ovariectomized rats,effects of PEMFs on, 274e282

Silver-enhanced in situ hybridization, for evaluating HER2gene status in invasive breast carcinoma, effective-ness of, 139e144

Single nucleotide polymorphisms (SNPs), effects in KATP

channel genes on type 2 diabetes in Turkish popula-tion, 317e323

Sirtuin 1 polymorphism, with BMD and body mass index,association study of, 363e368

SLC4A1. See Solute carrier family 4, anion exchanger,member 1

Small interfering RNA (siRNA), based gene silencing,overexpression of E2F3 in breast cancer using,415e422

Smoker, never, in five Latin American cities, airflowobstruction in, 169e175

SNPs. See Single nucleotide polymorphismsSolute carrier family 4, anion exchanger, member 1

(SLC4A1), in two unrelated Chinese families withdRTA, identification of two novel mutations in,298e304

Stable angina, and AMI, correlates with platelet activation,number of microparticles generated during, 31e35

Stem cellderived from lipoaspirated human adipose tissue, in vitro

generation of functional insulin-producing cellsfrom, 83e88

embryonic and induced pluripotent, therapeutic potentialof motor neurons differentiation from, 1e10

from scarce sources, microcapillary culture method for invitro expansion of, 423e430

Stem cell therapy, for treatment of end-stage liver diseasesby regulating the Notch signaling pathway, possi-bility of the enhanced progression of, 585e587

Students, physically active, intermittent maximal exerciseimproves attentional performance in, 125e131

STXBP4/COX11 rs6504950 (GOA) polymorphism, andrisk of breast cancer, association of, 383e388

TTacrolimus, dosing, CYP3A5 polymorphism in Mexican

renal transplant recipients and its association with,283e287

Takayasu arteritis (TA), extracellular matrix metalloprotei-nases remodeling in, 406e410

Tau protein, role in neuronal damage in Down syndromeand Alzheimer’s disease, 645e654

Telomeres, length, and subtelomeric methylation, alterationin human endothelial cell under different levels ofhypoxia, 15e20

Thrombocytosis, as predictor of distant recurrence inpatients with rectal cancer, 305e311

Thyroid peroxidase (TPO), gene, in a family with intellec-tual disability, next generation sequencing revealsa novel intragenic deletion of, 312e316

TIMP-2. See Tissue inhibitor of metalloproteinases-2Tissue inhibitor of metalloproteinases-2 (TIMP-2), and

MMP-2, with prostate cancer susceptibility inNorth India, association of polymorphisms in,117e124

TNF. See Tumor necrosis factorTNF-a. See Tumor necrosis factor-aToluene, benzene-xylene, production of IL-10, TNF and IL-

12 by PBMCs in Mexican workers exposed toa mixture of, 51e57

Total bilirubin, serum concentration, and FRS in Koreanpopulation, association between, 288e293

TPO. See Thyroid peroxidaseTransient receptor potential channel 3 (TRPC3), role in

human internal mammary artery, 431e437Treponema pallidum, at four general hospitals in the state of

Morelos Mexico, maternal/child seroprevalence ofantibodies against, 571e577

Trichostatin A, ameliorates myocardial ischemia/reperfu-sion injury through inhibition of endoplasmic retic-ulum stress-induced apoptosis, 190e196

TRPC3. See Transient receptor potential channel 3Tumor, breast, benign and malignant, evaluation of PDE5

and PDE9 expression in, 470e475Tumor necrosis factor-a(TNF-a), and serum ghrelin level

in patients with previous myocardial infarction,548e554

Tumor necrosis factor (TNF), IL-10, and IL-12, by PBMCsin Mexican workers exposed to a mixture ofbenzene-toluene-xylene, production of, 51e57

Turkey, effects of SNPs in KATP channel genes on type 2diabetes in, 317e323

UUpper extremity, nerve conduction velocities and the rela-

tionship between fibromyalgia and carpal tunnelsyndrome, evaluation of, 369e374

VVaccines

development of, expression of beta defensin 2 in experi-mental pulmonary tuberculosis a tentative approachfor, 324e328


a 23-valent pneumococcal polysaccharide, amongMexican children, immunogenicity of, 402e405

Val158Met polymorphism, in COMT gene and risk ofpreeclampsia in Chinese population, associationbetween, 154e158

Vardenafil, ameliorates calcium mobilization in pulmonaryartery smooth muscle cells from hypoxic pulmonaryhypertensive mice, 265e273

Vitamin B complex, and shilajit, for prevention of Alz-heimer’s disease, therapeutic role of, 699e704

WWnt/b-catenin, signaling pathway, and bone mass, in

ovariectomized rats, effects of PEMFs on, 274e282

XXylene, benzene-toluene, production of IL-10, TNF and IL-

12 by PBMCs in Mexican workers exposed toa mixture of, 51e57

Documents

Subject Index–Volume 43