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Structural Genomics, ISGO, and Structural Genomics Task Forces
Open ISGO Structural Genomics Task Force Meeting
ISGO International Structural Genomics Conference
Berlin, 10 October 2002
Udo Heinemann (MDC, Berlin)
Structural Genomics
A large-scale project to determine the three-dimensional
shapes of all proteins and other important biomolecules encoded by the genomes of key
organisms
Definition phrased at the April 2001 Second International Structural Genomics Meeting, Airlie House, VA, USA
Structural Genomics
The Structural Genomics Project aims at determination of the 3D structure of all proteins.
This aim can be achieved in four steps:
• Organize known protein sequences into families.
• Select family representatives as targets.
• Solve the 3D structure of targets by X-ray crystallography or NMR spectroscopy.
• Build models for other proteins by homology to solved 3D structures.
http://www.structuralgenomics.org/main.html
A Brief History of Structural Genomics1995 SG project proposed in Japan
1997 Apr. SG pilot project starts at RIKEN Inst.
1997 SG studies initiated through DOE, NIGMS in US
1998/99 Initial SG projects start in Canada, Germany, US
1999 June Call for SG pilot projects issued by NIGMS/NIH
2000 Jan.OECD Committee for Scientific and Technological Policy (CSTP) proposes to initiate SG studies
2000 Apr. 1st International SG Meeting, Hinxton, UK
2000 June OECD/Global Science Forum (GSF) and SG Workshop, Florence, Italy
2000 Sep. SG: From Gene to Structure to Function, Cambridge, UK
2000 Sep. NIGMS Protein Structure Initiative starts in US with 7 Centers
2000 Nov. International Conference on SG (ICSG 2000), Yokohama, Japan / International SG Task Force Meeting / OECD/GSF Meeting
2001 Jan.OECD/CSTP/GSF, Paris, France – Further Study on SG
2001 Apr. 2nd International SG Meeting, Airlie House, US – Start of ISGO
2001 Sep. NIGMS Protein Structure Initiative adds 2 new centers
2002 Mar. European Commission announces funding of Structural Proteomics in Europe (SPINE)
2002 Apr. National project on Protein Structural and Functional Analyses starts in Japan
2002 Oct. ISGO International Conference on SG (ICSG 2002), Berlin, Germany
Projects
Taken fromwww.isgo.org
Ontario Centre for SG
Montreal-Kingston Bacterial SG Initiative
Montreal Network for Pharmaco-Proteomics and SG
CyberCell Project
Structural Proteomics in Europe (SPINE)
SG of Mycobacterium pathogens
SG of Eukaryotes
Yeast SG
SG of Orphan E. coli Genes
Protein Structure Factory
RIKEN SG/Proteomics Initiative
National Project on Protein Structural and Functional Analyses (7 centers)
Biological Information Research Center (BIRC)
The Korean Structural Proteomics Research Organization
National Centers for Competence in Research (NCCR)
North West SG Centre
Oxford Protein Production Facility
Cambridge Group
New York SG Research Consortium
Midwest Center for SG
Berkeley SG Center
Northeast SG Consortium
TB SG Consortium
Southeast Collaboratory for SG
Joint Center for SG
SG of Pathogenic Protozoa Consortium
Center for Eukaryotic SG
Structure 2 Function Project
Canada
EuropeFrance
Germany
Japan
Korea
SwitzerlandUK
USA
Structural Genomics
Structural Genomics: A large-scale project to determine the three-dimensional shapes of all proteins and other important biomolecules encoded by the genomes of key organisms
SG is genome-driven, aims at completeness
SG needs high throughput, automation
SG needs international coordination to foster cooperation and avoid waste of resources
International Coordination
www.proteinstrukturfabrik.de
International agreements
• The projects make their structure analysis targets public (Target Tracking)
• The projects grant mutual technical help
• Protein structures from structural genomics projects must meet stringent quality criteria
• The structures are published in a timely manner
• Deriving utility from protein structures is not excluded
The International Structural Genomics Organisation (ISGO)
Initiated at Airlie House Meeting (2001)
Activities
• International coordination (task forces)• Workshops, meetings• Conferences
Appointed officers
• Udo Heinemann (Germany / Europe)• Tom Terwilliger (USA / North America)• Shigeyuki Yokoyama (Japan / Asia)
Structural Genomics Taskforces
Informatics (J. Moult, U. Maryland, USA)
Numerical Criteria for Evaluating and Assuring Structure Quality (R. Read, U. Cambridge, UK)
Tracking and Registra-tion of Targets (S. Bryant, NIH, Bethesda, USA)
Deposition, Archiving, and Curation of the Primary Information (H. Berman, Rutgers U., USA)
Mechanisms for Publication and Recording of Methods (G. Dodson, U. York, UK)
Intellectual Property (B. Skene, Wellcome Trust, UK, and J. Norvell, NIGMS, USA)