Striatal intrinsic plasticity and information processing Striatal intrinsic plasticity and information processing in the corticostriatal funnelin the corticostriatal funnel

Cortical synchronizationCortical synchronization

Firing of striatal medium spiny neuronsFiring of striatal medium spiny neurons

Short-term intrinsic plasticityShort-term intrinsic plasticity

+

Cortical requirements for striatal MS neuron firingCortical requirements for striatal MS neuron firing

Cerebral cortexCerebral cortex

StriatumStriatum

Intrinsic plasticityIntrinsic plasticity

Membrane constants of MS neurons are not constantMembrane constants of MS neurons are not constant

From Charlie Wilson

Vm

Experimental demonstration of a Experimental demonstration of a need of cortical spatio-temporal synchronyneed of cortical spatio-temporal synchrony

DesynchronizedDesynchronized SynchronizedSynchronized

Temporal and spatial contraction in the CS pathwayTemporal and spatial contraction in the CS pathway

Cortical synchronization as a trigger for striatal intrinsic plasticity?Cortical synchronization as a trigger for striatal intrinsic plasticity?

Spike-dependent increase in membrane excitabilitySpike-dependent increase in membrane excitability

A

B

C

D

Spike-dependent facilitation of cortical inputsSpike-dependent facilitation of cortical inputs

Effects on the corticostriatal input-output relationshipEffects on the corticostriatal input-output relationship

No change in synaptic strengthNo change in synaptic strength Decrease in spike threshold and latencyDecrease in spike threshold and latency

Role of the striatal KRole of the striatal K++ current I current IASAS

In vitro experiments

Activation of outwardK+ current (IAs)

Properties of IIASAS

Slow recovery from inactivation

( ~ 300 ms)

Striatal intrinsic plasticity:Striatal intrinsic plasticity:Changes in the cortical parameters effective for striatal neurons firing and

optimization of the information transfer in the corticostriatal pathway

Intrinsic plasticityIntrinsic plasticity

Séverine Mahon Séverine Mahon (University College of London)(University College of London)

Stéphane Charpier (Stéphane Charpier (INSERM U667 Collège de France)INSERM U667 Collège de France)

Guilaume Casassus Guilaume Casassus (UMR CNRS 5091Institut François Magendie)(UMR CNRS 5091Institut François Magendie)

Christophe Mulle Christophe Mulle (UMR CNRS 5091Institut François Magendie)(UMR CNRS 5091Institut François Magendie)