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Stochastic gating of an Assymetric Exclusion Process for applications in biological transport A Jamie Wood q q b F b B

Stochastic gating of an Assymetric Exclusion Process

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b F. b B. Stochastic gating of an Assymetric Exclusion Process. for applications in biological transport. A Jamie Wood. b F. b B. Variable entrance and exit rates. New – but similar to a model used to describe growing fungal hyphae ( Sugden and Evans 2007 ). - PowerPoint PPT Presentation

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Page 1: Stochastic gating of an Assymetric Exclusion Process

Stochastic gating of an Assymetric Exclusion

Processfor applications in biological transport

A Jamie Wood

qq

bF bB

Page 2: Stochastic gating of an Assymetric Exclusion Process

Variable entrance and exit rates

New – but similar to a model used to describe growing fungal hyphae (Sugden and Evans 2007).

qq

bF bB

In order to account for the some biological transport we need to introduce a “carrier” particle that mediates the entrance and exit from the tracks

Page 3: Stochastic gating of an Assymetric Exclusion Process

Simple results

NBF

F

NBF

lbb

b

lbbdt

d

)()1(

Self Consistency requires

)1(

)(,

212

:

)1(

)(,2

1:

212

,21:

F

BF

F

BF

F

BF

F

BF

b

bb

b

bbHD

b

bbLD

b

bbMC

Page 4: Stochastic gating of an Assymetric Exclusion Process

Alterations in PD – Fast Rates

Page 5: Stochastic gating of an Assymetric Exclusion Process

Alterations to PD – Slow rates

Page 6: Stochastic gating of an Assymetric Exclusion Process

Improved results

NNBNFNNN

NNNN

NBF

llblblldt

ld

llldt

ld

lbbdt

d

)1()1(

)1(

))1(

1

1

)24)((14

)1)(2)((,2

1:

FBFF

BFBF

bbbb

bbbbMC

Shifts phase boundary so that now, e.g.

Page 7: Stochastic gating of an Assymetric Exclusion Process

Double gating

NBF

Fb

BF

Fa

lbb

b

laa

a

11

LD-HD phase boundary given by curve

0)(

)()(

)()(

222

FF

BFFBFF

BFBF

ab

bbaaab

bbaa

Page 8: Stochastic gating of an Assymetric Exclusion Process

Thanks toJames MoirMartin Evans