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Friday, April 20, 20188:00 AM – 5:20 PM
toSaturday, April 21, 2018
8:00 AM – 2:35 PM
Frances C. Arrillaga Alumni CenterMcCaw HallStanford, CA
Update on Current Advances in BMT and Cancer
ImmunotherapyA Continuing Medical Education Conference Presented by the Department of Medicine and the Division of Blood & Marrow Transplant at the Stanford University School of Medicine
Sponsored by the Stanford University School of Medicine
Register online at cme.stanford.edu/BMT
Stanford Cancer Immunotherapy and Blood & Marrow
Transplant Symposium
Conference Information
STATEMENT OF NEEDThis CME activity seeks to fulfill the need in the transplant and cellular therapeutics community to increase and improve knowledge as well as management skillset in performing stem cell transplantation and cellular therapeutics to optimize patients’ clinical outcomes. The conference will utilize lectures, debate and panel discussion to achieve the educational objectives.
TARGET AUDIENCEThis national conference is designed to meet the educational needs of:
• Physicians practicing in hematology, oncology, and internal medicine• Physicians Assistants• Nurse Practitioners• Nurses
LEARNING OBJECTIVESAt the conclusion of this activity, learners will be able to:
• Review the difference of transplant-related mortality/morbidity and chance of disease relapse in myeloablative regimen, in reduced intensity regimen and in non-myeloablative regimen in order to determine the best treatment options for your patients presenting with myelodysplastic syndrome.
• Utilize Stanford guidelines on the criteria for ICU transfer of critically ill post-transplant patients.
• Determine the different pathways involved in the pathogenesis of Graft-Versus-Host Disease (GVHD) and use them as a guide for choosing different classes of treatment in individual patients.
• Analyze the pros and cons of different donor sources based on current clinical data in order to determine which sources to use with your patients.
• Review the application of high-throughput sequencing (HTS) to monitor minimal residual disease after transplant and in managing disease relapse.
• Review the outcome data using CD-19 targeting CAR T-cells from different institutes, and be familiar with the guidelines in managing therapy-related complications.
ACCREDITATIONThe Stanford University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CREDIT DESIGNATIONThe Stanford University School of Medicine designates this live activity for a maximum of 11.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The California Board of Registered Nursing recognizes that Continuing Medical Education (CME) is acceptable for meeting RN continuing education requirements as long as the course is certified for AMA PRA Category 1 CreditTM (rn.ca.gov). Nurses will receive a Certificate of Participation following this activity that may be used for license renewal.
COMMERCIAL SUPPORT ACKNOWLEDGEMENT This CME activity is supported in part by educational grants. A complete list of commercial supporters will be published in the course syllabus.
FACULTY DISCLOSUREThe Stanford University School of Medicine adheres to ACCME Criteria, Standards and Policies regarding industry support of continuing medical education. Disclosure of faculty and their commercial relationships will be made prior to the activity.
REGISTRATIONRegistration fee includes course materials, certificate of participation, continental breakfast, and lunch.
Register online with a Visa or Master Card by visiting cme.stanford.edu/BMT. If you prefer to pay by check or need assistance, please call (650) 497-8554 or email [email protected]. Be sure to register with an email address that you check frequently. Your email address is used for critical information, including registration confirmation, evaluation, and certificate.
CANCELLATION POLICY Cancellations received in writing no less than 30 days before the course will be refunded, less a 20% administrative fee. No refunds will be made on cancellations received after March 21, 2018. Please send cancellation requests to [email protected].
Stanford University School of Medicine reserves the right to cancel or postpone this program if necessary; in the event of cancellation, course fees will be fully refunded. We are not responsible for other costs incurred such as non-refundable airline tickets or hotel penalties.
CONFERENCE LOCATIONFrances C. Arrillaga, Alumni Center – McCaw Hall 326 Galvez Street, Stanford, CA 94305(650) 723-2021
PARKING, MAPS & DIRECTIONSFor driving directions, maps and parking at Arrillaga Alumni Center please visit: https://alumni.stanford.edu/get/page/resources/alumnicenter/directions
VISITING STANFORD AND ACCOMMODATIONSNearby Hotels:Sheraton Palo Alto Hotel (650) 328-2800The Westin Palo Alto (650) 321-4422Please contact the hotel directly to secure a reservation.http://visit.stanford.edu/plan/lodging
CONTACT INFORMATIONFor questions about the conference, please contact Yolanda Cervantes, Conference Coordinator at (650) 724-9549 or [email protected].
Stanford Center for Continuing Medical Education1520 Page Mill Road, Palo Alto, CA 94304Phone: (650) 497-8554 • Email: [email protected]: cme.stanford.edu
Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the
Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008. If you have needs that require special accommodations, including dietary concerns, please contact the CME Conference Coordinator.
ATTENDEE TYPE FEES FEESEarly Bird Rate After March 20, 2018
Physician $475.00 $650.00Nurse/Allied Health Professionals $350.00 $475.00
Please register early – space is limited
FRIDAY, APRIL 20, 20188:00-8:35
8:35-8:40
8:40-8:50
8:50-9:15
9:15-9:40
Registration and Breakfast
Introductory RemarksLaura Johnston, M.D. and Wen Kai Weng, M.D., Ph.D.
Welcome: 30 Years of Stanford BMTRobert Negrin, M.D.
The Intensity of Conditioning in Myeloid Malignancy: Myeloablative vs Reduced Intensity vs Non-Myeloablative Frederick R. Appelbaum, M.D.
Targeting the Stem Cell Niche with Antibody: Allogeneic Transplant in Children with Severe Combined Immunodeficiency (SCID)Judith Shizuru, M.D., Ph.D.
9:40-10:05 Graft Manipulation: Making of a Safer Transplant
10:05-10:30 Understanding the Biology of GVHDRobert Negrin, M.D.
10:30-10:45 Coffee Break
10:45-11:10 The Struggling and Triumphant Story of CMV Management in Allogenic TransplantJanice Brown, M.D.
11:10-11:35 Cell Therapy with In-Vitro Engineered T Regulatory Cells to Modulate GVHDMaria Grazia Roncarolo, M.D.
11:35-12:00 Inducing Organ Transplant Tolerance with Hematopoietic CellsSamuel Strober, M.D.
12:00-12:25 The Intestinal Microbiome and Its Clinical ImplicationAmi Bhatt, M.D., Ph.D.
12:25-1:10 Lunch
1:10-1:30
1:30-1:55
1:55-2:20
2:20-2:45
2:45-3:00
3:00-3:25
3:25-3:50
3:50-4:15
Managing the Criticall Ill Patients: The ICU ProjectPatricia Jenkins, R.N., B.S.N., M.P.H.
Building an Allogeneic Transplant Model Using Cutaneous T-Cell LymphomaWen-Kai Weng, M.D., Ph.D.
Young Adult ALL: A Lesson LearnedLori Muffly, M.D., M.S.
Hematopoietic Cell Transplantation in Hemoglobinopathies Alice Bertaina, M.D.
Coffee Break
Smoldering Multiple Myeloma: Is It Time to Treat?Irene M. Ghobrial, M.D.
Teaching a Young Dog New Tricks: The Story of BTK Inhibitor David Miklos, M.D., Ph.D.
Harness the Power of Graft-Versus-Tumor EffectRobert Lowsky, M.D.
4:15-5:20
5:20-6:30
The Debate: Double Cord vs Haploidentical vs Unrelated DonorModerator: Laura Johnston, M.D.Case Scenario Laura Johnston, M.D.Double Cord Blood Stem Cells Nelson Chao, M.D. Haploidentical Donor Andrew Rezvani, M.D. Unrelated Donor Frederick R. Appelbaum, M.D. RebuttalPanel Discussion Frederick R. Appelbaum, M.D., Nelson Chao, M.D., and Andrew Rezvani, M.D.
Wine and Cheese ReceptionArillaga Center
SATURDAY, APRIL 21, 20188:00-8:40
8:40-8:50
8:50-9:20
9:20-9:50
Registration and Breakfast
Introduction for Day 2Crystal Mackall, M.D.
CD19-CAR for Adult B Cell Malignancy: Efficacy and Safety David Maloney, M.D., Ph.D.
CD19-CAR for Pediatric B-All: State of the FieldKara Davis, D.O.
9:50-10:20 CD19-CAR for DLBCL and BeyondDavid Miklos, M.D., Ph.D.
Elizabeth Budde, M.D., Ph.D.
12:10-1:20 Lunch
1:20-1:50
1:50-2:20
2:10-2:35
CARs for Brain Tumors: Seattle Experience Michael Jensen, M.D.
Next Generation CAR T CellsCrystal Mackall, M.D.
Closing Remarks
*Opportunities for Q&A will be provided at the conclusion of each presentation.
ProgramProgram (Subject to change)
Everett Meyer, M.D., Ph.D.
10:20-10:40 Coffee Break
10:40-11:10 CARs for Leukemia: Antigen Evasion and Targeting CD22Terry Fry, M.D.
11:10-11:40 CARs Associated Neurotoxicity: Emerging Insights Cameron Turtle, M.B.B.S., Ph.D., F.R.A.C.P., F.R.C.P.A.
11:40-12:10 AML and CD123
Stanford Cancer Immunotherapy and Blood & Marrow Transplant Symposium 2018 Update on Current Advances in BMT and Cancer Immunotherapy
Register online at cme.stanford.edu/BMT
Faculty All faculty members and conference planners are from Stanford University School of Medicine (unless otherwise noted).Judith Shizuru, M.D., Ph.D.Professor of Medicine (Blood and Marrow Transplantation)Samuel Strober, M.D.Professor of Medicine (Immunology and Rheumatology)
GUEST FACULTYFrederick R. Appelbaum, M.D.Executive Vice President, Deputy Director Fred Hutchinson Cancer Research Center Professor, Medical Oncology Division University of Washington School of Medicine
Elizabeth Budde, M.D., Ph.D.Assistant Professor, Hematology and Hematopoietic Cell Transplantation City of Hope
Nelson J. Chao, M.D.Professor of Medicine, Duke University Chief, Division of Cell Therapy in the Department of Medicine
Terry J. Fry, M.D.Professor of Pediatrics, Hematology and ImmunologyCo-Director, Human Immunology and Immunotherapy Initiative and Director of Cancer Immunotherapy University of Colorado School of Medicine Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics, Children’s Hospital ColoradoCenter for Cancer and Blood Disorders
Irene M. Ghobrial, M.D.Director, Michele & Steven Kirsch Laboratory Director, Clinical Investigator Research ProgramSenior Physician Dana-Farber Cancer InstituteAssociate Professor of Medicine, Harvard Medical School
Michael Jensen, M.D.Professor of Pediatrics, University of Washington School of Medicine Director of the Ben Towne Center for Childhood Cancer Research, SCRI
David Maloney, M.D., Ph.D.Member, Clinical Research Division,Medical Director, Cellular Immunotherapy Leonard and Norma Klorfine Endowed Chair for Clinical Research,Fred Hutchinson Cancer Research CenterProfessor of Medicine, Division of Oncology, University of WashingtonService Medical Director, Cellular Immunotherapy and Bezos Family Immunotherapy ClinicSeattle Cancer Care Alliance
Cameron Turtle, M.B.B.S., Ph.D., F.R.A.C.P., F.R.C.P.A.Associate Professor of Medicine, University of Washington School of Medicine
COURSE CO-DIRECTORSCourse DirectorLaura Johnston, M.D.Associate Professor of Medicine (Blood and Marrow Transplantation) Division of Blood and Marrow Transplant
Course Co-DirectorWen-Kai Weng, M.D., Ph.D. Associate Professor of Medicine (Blood and Marrow Transplantation) Division of Blood and Marrow Transplant
STANFORD FACULTYAlice Bertaina, M.D.Associate Professor of Pediatrics
Ami Bhatt, M.D.Assistant Professor of Medicine (Hematology) and Genetics
Janice Brown, M.D.Professor of Medicine, Blood and Marrow Transplantation
Kara Lynn Davis, D.O.Assistant Professor of Pediatrics (Hematology/Oncology) at Lucile Packard
Patricia Jenkins, R.N., B.S.N., M.P.H. Nurse Manager, Stanford BMT
Robert Lowsky, M.D.Professor of Medicine (Blood and Marrow Transplantation)
Crystal Mackall, M.D.Professor of Pediatrics (Hematology/Oncology) and of Medicine
Everett Meyer, M.D., Ph.D. Assistant Professor of Medicine (Blood and Marrow Transplantation)
David Miklos, M.D., Ph.D. Associate Professor of Medicine (Blood and Marrow Transplantation)
Lori Muffly, M.D., M.S.Assistant Professor of Medicine (Blood and Marrow Transplantation)
Robert Negrin, M.D.Professor of Medicine, Division Chief, Stanford BMT
Andrew Rezvani, M.D. Assistant Professor of Medicine (Blood and Marrow Transplantation)
Maria Grazia Roncarolo, M.D. George D. Smith Professor of Pediatrics (Stem Cell Transplantation) and Medicine (BMT)