DRS. PUCK ANDCARUTHERSColorado’s BiosciencePioneerspage 15

DIRECTORYOF COLORADO BIOSCIENCECOMPANIES &RESOURCESpage 24

ADVANTAGECOLORADODoing Business inColoradopage 13

FITZSIMONSA Life SciencesCommunityfor the Futurepage 22

COLORADOMedical DeviceMeccapage 6

2004

JUNE 2004

H O M E S • O F F I C E S • S H O P S • P A R K S

Front Row Center for Denver Business

Location, location, location. At Stapleton, your business and its employees will be

uniquely positioned just 10 minutes from downtown Denver and 20 minutes from DIA.

Stapleton is home to The Denver BioScience Center. The strategic and economic

advantages of this 200+ acre center are unique in Denver and can add up to a real

opportunity for your business — today and in the future.

For more information call 303.382.1800StapletonDenver.com

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D E N V E R

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3

BioscienceC O L O R A D O

in this issue

15

D I R E C T O R Y

26 RESEARCH INSTITUTES

29 BIOTECHNOLOGY/PHARMACEUTICAL

COMPANIES

34 MEDICAL DEVICE COMPANIES

40 BIOSCIENCE RESOURCES

4 The Power of Multi-disciplinary Cooperation

6 Colorado — Medical Device Mecca

8 University of Colorado Helps Build theBiotechnology and Biomedical Industry

10 Bioscience Research in Northern Colorado and Colorado State University

12 Welcome. A messagefrom Governor Bill Owens

13 ADVANTAGE COLORADO

FEATUREColorado’sBiosciencePioneer Spirit

19 Bioscience Real Estate Opportunity in Colorado

20 READY, SET, GROW! INFRASTRUCTURE FORBIOSCIENCES IN COLORADO

22 Fitzsimons - A life science communityfor the future

Published By: Colorado BioScience Association and Colorado Office of Economic Development and International TradeEditor: Downs MarketingDesign: Tackett Advertising, Ltd

4

At the

beginning

of the new

millennium, two

seemingly unrelated

events occurred that

may change the course

of biomedical history.

By M. Karen Newell

The first was the sequencing of the entirehuman genome. The second was theunexpected loss of employment forthousands of high tech workers. Theseevents have became intertwined in asurprising and important way. Thefollowing is my personal tale of howworld events, scientific discovery, and anintroduction to talented, yet unemployed,engineers, computer scientists andmathematicians, become catalysts forchange and resulted in the creation of aresearch institute and at least three newcompanies in southern Colorado.

I took a ten year leave betweenacquiring my Bachelor’s Degree inMicrobiology and obtaining my Ph.D.in Immunology to be a parent. Re-entering graduate school with a tenyear gap had its challenges, but also itsunique rewards. I am extremelygrateful to those that decided thatretraining me might be worthwhile.

My work concerns how cells die. Whileat the University of Vermont as a newfaculty recruit, I was introduced to agroup of physicians, pharmacologists,and endocrinologists. Collaboratively,we began to unravel an unexpectedconnection between the immunesystem, control of cell death, andcellular energy metabolism.Experimental results produced largequantities of scientific data and anurgency to understand and interpret allthat data. In 1999, I moved to theUniversity of Colorado at ColoradoSprings (UCCS). We expanded theresearch and created the Institute ofBioenergetics that focuses on energyand the immune system. We continuedto be frustrated by our need for timelyresults from more data than we couldpossibly handle. To bridge this gap, Istarted my first foray into computationalbiology by trying to use the computerskills of our students to process thisgrowing body of data. We received a

Unexpected Results...

The Power of Multi-disciplinary Cooperation

seed grant from the Colorado Instituteof Technology to create a Certificate inComputational Biology and joinedforces with the system-wide Center forComputational Biology in Denver.

In November 2003, the importance ofmulti-disciplinary cooperation hithome when Mr. Robert “Rocky” Scott,CEO of the Colorado SpringsEconomic Development Council(EDC), requested that I speak at anevent jointly sponsored by the PikesPeak Work Force and his organization.The audience was mostly localunemployed high tech workers whowere trying to find jobs with help fromPikes Peak Work Force. I presented anoverview of our work and I describedour efforts to create a new certificateprogram in computational biology.Interest in the certificate program was

overwhelming and enthusiastic. Withapproval from the Biology Departmentat UCCS, we finalized the firstCertificate in Bioinformatics andComputational Biology and accepted ourfirst students in January 2004. Alreadythe students are creating new software,designing new medical devices, andmathematically modeling complexbiological systems. I predict that the newtechnologies and skills being created willprovide self employment and new careeropportunities for many of these students.

Perhaps sharing our experiencesencourages cross-seeding betweenbioscience research and the world ofmath and technology. Extraordinaryamounts of newly acquired data can beprocessed and understood using thecomputational talents of newly trainedhigh tech workers and students

potentially creating unprecedentedmedical breakthroughs. ◆

M. Karen Newell, Ph.D. is the Chief Scientific

Director of the CU Institute of Bioenergetics and

the Clement and Margaret Markert Endowed

Professor of Biology at the University of

Colorado, Colorado Springs. Dr. Newell's

scientific interests include cellular metabolism,

the immune system, and cell death.

5

B i o s c i e n c e C O L O R A D O

For nearly four decades in Colorado,

ISEC, Inc. has set a high standard for

laboratory and bio-tech construction.

ISEC is your single source whether you

need one room of casework and

equipment, or an entire facility built

from the ground up.

Quality, innovation and integrity are

our core values.

ISEC, Inc.Rocky Mountain Region

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Contact: Joan Norblom, Sr. Vice President - JLNorblom@isecinc.com

Integrity and innovation.Right down to the finish.

specialized building interiors and equipmentcommitted to advancing effectiveness and efficiency

T H E C O L O R A D O

A D V A N T A G E

More high tech workers per capitathan any other state in the nation.In 2002, 98 of every 1000 privatesector workers were employed byhigh tech firms.

6

Byers Peak (www.byerspeak.com) is an excellent example ofa spinoff entrepreneur. When the Renal Products division ofGambro AB in Lakewood decided to locate its equipmentmanufacturing in Europe, Phil Prescott and Doug Pruettseized the opportunity to fill the vacuum left by Gambro’sdecision. They created Byers Peak to perform repair andrefurbishment services for Gambro’s hemodialysis machines.Later, they expanded into contract manufacturing,distribution and field services. Byers Peak credits its successto entrepreneurship, Colorado’s experienced talent pool,economic development assistance from government agenciesand support from the Colorado BioScience Association(CBSA) (www.cobioscience.com).

Two local entrepreneurs, with a combined 34 yearsexperience in various Colorado medical device companies,Jonathan Thorne and Kevin Morningstar pooled their ideas

and created Silverglide Surgical Technologies, Inc.(www.silverglidesurgical.com) in 1997. They manufactureelectrosurgical instruments enhanced with the SILVERGlide®

non-stick technology. This technology prevents the stickingand buildup of tissue, which results in faster, more precisesurgery. Silverglide is not a spinoff of one of Colorado’selectrosurgery companies such as Valleylab(www.valleylab.com) or Conmed Electrosurgery(www.conmed.com), but is a de novo company that simplydeveloped a better mousetrap. Jonathan relishes the “huge”talent pool in the state and readily available senior advisorswho “keep me from making dumb mistakes.”

Founded in 1969, Denver Biomedical, Inc. (DBI)(www.denverbiomedical.com) is a global leader in designingand manufacturing specialized critical care medical devicesfor fluid management of ascites and pleural effusion. From

Colorado has one of the highest densities of medical device

manufacturers in the nation. Why is Colorado home to so

many great medical device entrepreneurs? Entrepreneurs will

tell you it’s not just the allure of the Rocky

Mountains, but rather Colorado’s

powerful and sustainable

entrepreneurial spirit.

by Ed Wood

Colorado - Medical Device Mecca

7

its commitment to its customers, DBI led the industry tohelp patients receive reimbursement for fluid managementproducts. Bonnie Vivian, CEO, tapped into a pool ofsuccessful retired Colorado medical device executives forbusiness advice and key employees. Vice Presidents of Sales,Marketing and Manufacturing came to DBI with years ofexperience from other Colorado medical device companies.

Some medical device companies, such as Medical SimulationCorporation (www.simsuiteed.com), got their start bytransferring technology from one of Colorado’s researchuniversities. Others, such as Baxa Corporation(www.baxa.com), relocated their 10 person company fromIllinois to Colorado in 1981. Baxa founder, Brian Baldwin,started an industry association called the Colorado MedicalDevice Association, which later merged with the ColoradoBiotechnology Association to form CBSA. Baxa’s success nowcontinues under his son Greg’s leadership.

Whether a de novo start-up, a spinoff from a larger company,a tech transfer or a transplant from another state, Colorado’sentrepreneurs find success in a state blessed not only withthe grandeur of the Rocky Mountains, but an infrastructurethat nourishes business. ◆

Ed Wood is the Executive Chairman of Mission Medical, Inc., a California

company that is automating the collection process for whole blood. He is

currently the CEO of Summit Roundtable, coaching medical companies to

achieve market and financial success.

T H E C O L O R A D O A D V A N T A G E

Colorado’s Medical Device location quotient equals1.52. This means the sector is 52 percent moreconcentrated in Colorado than nationally.

Battelle Memorial Institute 2003

8

The University of Colorado (CU) makes major contributions to

Colorado’s bioscience industry in two ways. First, the University

is a major source of scientific research that brings substantial

funding into the state. CU raised over $530 million in sponsored

research funding in 2003. This ranks CU in the top ten of public

research universities. Faculty includes three Nobel Laureates, nineteen

members of the National Academy of Sciences and seven MacArthur

Fellows. Second, CU has made a substantial commitment to transfer

commercially promising technology and research to private enterprise.

University of Colorado Helps Build theBiotechnology and Biomedical Industry

by Vivian Dullien

9

Since the 1980s, several CU discoverieswere fundamental to the growth of thebiotechnology industry. In 1983,faculty member Marvin Caruthersdevised a method to construct DNAfragments of predetermined sequencefrom five to about 75 base pairs long.This breakthrough made syntheticDNA available to biochemists,molecular biologists, and biologists.Since this groundbreakingachievement, CU discovered the NobelPrize winning ribozyme and SELEXmethod for generating diverse pools ofmolecules for research and drugdevelopment. These findings continue to attract new investment.

Over the last year, CU increased itsefforts to transfer technology andlicenses to experienced entrepreneursendorsed by private and venture capitalinvestors. The following examplesillustrate the scope and depth of CU’sresearch base.

• Working with Bill Arend, Amgenbrought a treatment for rheumatoidarthritis (KineretTM) to market.

• Fisher Scientific paid $80 million toacquire Dharmacon that marketedMarvin Caruthers’ RNAoligonucleotide synthesis process.

• Sirna Therapeutics licensed ThomasCech’s ribozyme discoveries and just completed a $53 million roundof funding.

• By licensing CU’s SELEX process,Larry Gold acquired financing forSomaLogic and identified an aptamer(MacugenTM) that EyeTech willjointly develop and market withPfizer.

• CU researchers and Myogen foundersMichael Bristow and Leslie Leinwandare jointly working with Novartis totest and develop cardiac diagnosticsand therapeutics.

• This year GlobeImmune, founded byDrs. Duke, Franzusoff and Bellgrau,is preparing a Phase I clinical trial ofan AIDS vaccine and has receivedSeries A venture investment worth$8M.

CU discoveries help fuel biotechnologyexpansion, evidenced in more than adozen new start-ups since fall of 2002.They include:

• AlphaSniffer, a joint developmentbetween CU’s Physics andMechanical Engineeringdepartments, will develop a portable,low-power device that quicklyidentifies gaseous or liquidchemicals. Dana Anderson and

Victor Bright obtained patents forthis technology.

• BaroFold, headed by John Carpenterof the Health Science CenterPharmaceutical Sciences and TedRandolph, professor of chemicalengineering at the Boulder Campus,aims to improve quality and yield ofrecombinant pharmaceutical proteins.

• Karen Newell’s CU Center forBioenergetics in Colorado Springslicensed promising cell metabolismdiscoveries to drug and nutraceuticalcompanies.

• Paul Wischmeyer, who received CU’s2003 “First Time Inventor” award,started a company that will beginhuman trials for treatment ofreperfusion injury and sepsis.

• Cardiologists John Carroll and JamesChen developed software to produceaccurate, high-quality images of thebeating heart. The software islicensed to Philips Medical Systemsand Medical Simulation Corp.

• Efectka Technologies licensed drugdiscovery software from ProteomicsFacility inventor Mark Duncan.

CU has contributed to thebiotechnology industry since itsconception. By encouraging cross-campus and interdepartmentalcollaborations and practicinginnovative technology transfer toprivate enterprise, CU acceleratesmarket adoption of new technologies.

B i o s c i e n c e C O L O R A D O

T H E C O L O R A D O

A D V A N T A G E

Most recently, a study conducted inChina and published in TheEconomist of London, ranked CUas the 11th best public university inthe world, and one of the 50 bestuniversities of any kind based oncriteria such as highly citedresearchers and Nobel laureates inselected fields.

Boulder Daily Camera, April 29th, 2004

The State of Colorado has a greatresearch university with the talent,science and funding to build a powerfulbioscience industry. ◆

Vivian Dullien, Ph.D, is Director of Technology

Transfer at the University of Colorado Health

Science Center.

10

Colorado State University

(CSU), a regional and

national leader in scientific

discovery, generated approximately

$200 million in sponsored research

activities in fiscal year 2004. CSU

actively engages with Northern

Colorado companies and

laboratories in the fields of

veterinary medicine, biotechnology,

engineering, agriculture, and

natural resources.

CSU collaborations with the Centers for Disease ControlDivision of Vector Borne Infectious Disease,the U.S. Department of Agriculture NationalWildlife Research Center and the U.S.Department of the Interior Natural ResourceLaboratories form a robust researchenvironment for important public health,homeland security and natural resourceresearch. Additionally, CSU offers theMacromolecular Resource Facility andLaboratory Animal Resources facilities on

a fee basis to private companies or institutes.

CSU has a long and successful history of collaborating andsupporting Northern Colorado bioscience companies. Thesecompanies include Heska Corporation, DAKO-Cytomation,Optibrand, XY, Inc., Mycos Research, Aurogen, Inc., Brotica,Inc., Gonex, Inc., Tagawa Greenhouses, PR Pharmaceuticalsand Atrix Laboratories, Inc. These collaborations andtransfer of technologies resulted in potential tuberculosisand Johne’s disease diagnostics, treatments for diabetes,termite control strategies, and non-invasive pet sterilization.In addition, CSU engages with the Colorado Wheat ResearchFoundation and the Colorado Certified Potato GrowersAssociation for research, introduction and commercializationof new crop varieties that are disease resistant.

Bioscience research inNorthern Colorado and

Colorado State Universityby Arundeep S. Pradhan

As the state’s land-grant university, CSU’s top priority is togenerate knowledge while simultaneously applying thatknowledge for society’s benefit. CSU meets this obligation by being a nationally ranked research university, graduatingqualified students and collaborating with local companies,federal laboratories and other institutions to create newtechnologies and economic growth. ◆

Arundeep S. Pradhan, Director for Technology Transfer, joined the

Colorado State University Research Foundation in 1999.

11

12

The State of Colorado is poised and ready to helpgrow your bioscience company.

Why Colorado? It’s very simple…Colorado has the 2nd most educatedworkforce in the country, access to seed and venture capital, world classuniversities and research institutions, the entrepreneurial infrastructure andservices you require, low taxes, business friendly tort law and little red tape.

What else could you want? How about a quality of life that includes over300 days of sunshine and abundant cultural and recreational activities.

You will be joining a robust bioscience cluster when you come to Colorado.With 240 companies employing over 17,000 scientists and technicians, there is abundant energyin Colorado’s life science industry. Colorado’s research institutions receive over $300 millionannually for research in the life sciences, a 31% growth rate compared to 27% for the nation. Thejewel in Colorado’s bioscience crown continues to be Fitzsimons, a world-class bioscience city thatcombines bioscience research, education, clinical and commercialization space in one square mile.

Elias Zerhouni, NIH Director, visited in 2003 and said of Fitzsimons, “You are poised to go to thenext step…no one has put together the firepower, intellectual and physical, that I see here today”.

Colorado is an undeniable technology leader and a myriad of objective rankings bear this out: ThePWC MoneyTree Survey showed that in 2003, Colorado’s companies secured $621 million, a 12%increase over 2002 which ranked Colorado 5th in the nation. The March 2004 Milken Institute“State Science and Technology Index” ranked Colorado number 3 for science and technology assets.The June 2003 National Policy Research Council’s “America’s Best Cities and States: The Annual GoldGuide to Leading Rankings” ranked Colorado number 2 overall among the 50 states and Denver #1in a diverse set of academic, research, association and trade group rankings.

The State of Colorado invites you to visit and discover first-hand theopportunities that are available to bioscience companies, entrepreneurs and investors. We look forward to working with you.

Bill OwensGovernor

NEW SEED FUNDDuring 2004, the Colorado legislature redirected $50 million in premium tax creditsto a new Colorado venture capital program under Senate Bill-106. Even in a toughfiscal environment, the legislature recognized the need to “seed” Colorado’s start-upcompanies. The legislation established a Venture Capital Authority to oversee the newprogram with assistance from the Colorado Office of Economic Development andInternational Trade. The Authority will convert the premium tax credits to cashthrough a competitive bid process and then will use the cash to fund selected venturecapital funds. A fund targeted to rural businesses will receive twenty five percent ofthe net cash proceeds and a fund targeted to businesses located throughout the statewill receive seventy five percent of the net cash proceeds. The selected funds willmake seed and early stage capital available to qualified Colorado businesses. It isexpected that a large portion of this funding will go into the bioscience industry.

R&D STATE SALES TAX REFUND Colorado bioscience companies doing research and development will receive arefund of state sales and use taxes paid on the sale, storage, use or consumption of tangible personal property to be used in Colorado directly and predominantly inresearch and development of biotechnology.

MANUFACTURING EQUIPMENT EXEMPTIONBioscience companies purchasing manufacturing equipment and machine tools that cost over $500 are exempt from state sales and use tax on these purchases. The following items are also exempt from state sales and use taxes: componentparts, fuels and electricity, ink and newsprint, aircraft parts used in generalmaintenance, interstate long distance telephone charges, farm equipment andmachinery and packaging materials.

ENTERPRISE ZONE TAX CREDITSBioscience companies located in an Enterprise Zone will receive the following tax credits:

• A $500 tax credit for each new full time employee • A $2000 tax credit per new employee hired in an economically depressed rural area • A $200 tax credit during the first two years of operations for each full-time employee

covered by health insurance • An additional $500 tax credit for each employee hired for agricultural processing or

manufacturing • A 3% investment tax credit for equipment purchased and used within the zone • A 3% tax credit for expenditures on research and development • A 10% tax credit for qualified job training within the enterprise zone

CONTACT INFORMATIONColorado Office of Economic Development and International TradeChristine Shapard, Biosciences and Emerging Technologies DirectorPhone: 303.892.3850Fax: 303.892.3820www.colorado.gov/oed

13

Advantage COLORADO

T H E C O L O R A D O

A D V A N T A G E

Through unique public-privatepartnerships, we’re leveragingColorado’s competitive advantage andimproving our market share in thebiotech and life sciences industries.Our state already has the criticalelements in place to become anational industry center.

Governor Bill Owens

14

Dr. Theodore T. Puck

Dr. Marvin H. Caruthers

Opportunities in Colorado are exceptional for biosciencepioneers whether they are an individual or a company. Thestate is home to several nationally ranked universities andresearch laboratories. According to the Colorado Office ofEconomic Development and International Trade, Coloradoranks first among the fifty states and ten Canadian provincesfor “economic freedom” at the state and local level—animportant consideration for any biotechnology,pharmaceutical or medical device start-up or relocatingcompany. The mountains, pleasant climate and naturalbeauty make the state a wonderful place to live. People loveliving and working here. All these factors make Colorado aunique place where bioscience students, scientists,entrepreneurs and businesses can thrive and contribute totwo generations of world-class life science research.

Colorado’s early contributions to bioscience came from thework of two brilliant scientific pioneers—Dr. Theodore T.Puck and Dr. Marvin H. Caruthers. Dr. Puck moved toColorado in 1946 to become a professor and chairman ofthe newly formed Department of Biophysics at theUniversity of Colorado (CU) School of Medicine. This wasan opportunity for Dr. Puck to grow a new department fromthe ground up and he jumped on it. With an annualdepartmental budget of only $5000, this pioneer taught amajor course to medical students, instituted a biophysicalscience Ph.D. program and raised additional fundingthrough grants. His department, including the laboratoryand offices, was first housed in an old converted lumber

storage room in the basement of the medical school. Fromthis unpretentious beginning, Dr. Puck was one of the firstto connect genetics and biochemistry in mammalian cells.

According to Dr. Puck, up to the late 1940s, genetics wasconsidered a separate field from medical science that focusedon plant and animal breeding based on the discoveries byMendel. When applied to animal and human matings, dataaccumulation was slow, expensive and uncertain. Dr. Puckwas determined to further investigate the link betweengenetics and biochemistry started by the research of Beadleand Tatum. He was one of the first to see how these conceptswhen applied to human genetic biochemistry could result inrevolutionary medical advances. He pioneered using somaticmammalian cells, rather than germ cells, to incubate humancells in cultures. His discovery enabled experimentationpreviously not possible in human genetics and biochemistry.Remarkably, Dr. Puck’s early human genetics research wasdone on his own time. Funding was not available for humangenetics from private or governmental organizations. It wastoo new and uncertain.

Dr. Puck organized the creation of the classification systemby which all scientists study human chromosomes. TheDenver Classification System was completed in 1960 andgives every indication of continued use today. What isextraordinary is all this work was done before chromosomebanding was available so each chromosome length had to bepainstakingly measured from its centromere. In 1961, theEleanor Roosevelt Institute (ERI) was formed to allow Dr.

15

The pioneer spirit that once prompted settlers to come to Colorado

is kept alive by two generations of Colorado bioscience

entrepreneurs. Colorado has a long history in bioscience that was

key to the growth of this field and industry in the United States. Colorado

researchers in the late 1940’s helped create the science by connecting

genetics and biochemistry. Later they provided key breakthroughs that

formed the biotechnology industry in the early 1980s.

QC O L O R A D O ’ S B I O S C I E N C E

Pioneer Spiritby John Downs

16

Puck to concentrate on his research,creating the only institute that EleanorRoosevelt allowed to use her name.According to Matthew Yeingst, VP ofDevelopment, the Institute wasfounded on the belief that biomedicaland genetic research is the most cost-effective, long-term approach to theeventual conquest of human afflictionslike cancer, premature aging, birthdefects and genetic diseases. At ERI,Dr. Puck pioneered the study oftoxicity in chemotherapy and radiology by determining the amount of x-raydosage needed to destroy cancer cells. His research is the basis for allradiation cancer treatment used today.

Today, this living legend maintains anactive lab at Eleanor Roosevelt Instituteat the University of Denver (ERI/DU)and currently works with the Centersfor Disease Control on cancerprevention. In addition to his currentappointment at ERI, Dr. Puck is aDistinguished Professor in theDepartment of Medicine at Universityof Colorado Health Sciences Center aswell as a Research Professor in theDepartment of Biochemistry andMolecular Genetics for the University ofColorado Medical Center. Dr. Puck isparticularly proud that many of hisyoung protégés have become prominentscientists. Several have been inductedinto the National Academy of Sciencesof which he is also a member.

Another Colorado bioscience pioneer isMarvin H. Caruthers, Ph.D. Dr.Caruthers is a Distinguished Professorof Chemistry and Biochemistry at theUniversity of Colorado. Dr. Caruthers isa renowned research scientist in the fieldof DNA synthesis and an inventor andmultiple patent holder of key enablingtechniques for the biotechnologyindustry. He joined the faculty of theUniversity of Colorado in 1973. Hisearly research focused on the synthesisof oligonucleotides, a chemicallysynthesized nucleic acid of any length.

In his article named, A Short History ofOligonucleotide Synthesis, Dr. Richard

Hogrefe, states that Dr. Caruthers worked out the solution to two majoroligonucleotide problems—theswelling of the organic polymersupports and the instability of thephosphitylated active nucleosideintermediate. His breakthrough was toexchange one leaving group, achloride, for another, an amine.Thisbrilliant but subtle finding increasedthe stability of these molecules and ledto the development of routineoligonucleotide synthesis processes.This technology was incorporated into“gene-machines” to synthesizing DNAused by biochemists, biologists,molecular biologists and biophysicalchemists for research applications andpharmaceutical development.

At about the same time, the Bayh-Doleact was signed into law allowingacademic institutions to own andpatent federally funded research. Thisgave Dr. Caruthers and other scientistswith promising research access tocapital to launch biotechnologycompanies. A new industry was created.

In 1980, Dr. Caruthers and severalother research scientists foundedAmgen. Amgen is now the largestbiotechnology company in the worldwith revenues of $8 billion. In 1981, heco-founded Applied Biosystems, Inc.,to commercialize the chemicalsynthesis of nucleic acids and thesequencing of proteins. AppliedBiosystems led the world in this fielduntil acquired by Perkin ElmerCorporation in 1991 for $450 million.More recently, Dr. Caruthers’ researchat CU focuses RNA synthesis and

various DNA analogs. His laboratorydevelops new chemistries forsynthesizing biological molecules andthen explores the potential biochemicaluses of these new derivatives. Thisresearch led to a CU spin-off,Dharmacon, based in Colorado.

Drs. Puck and Caruthers came toColorado about a generation apart andfor different reasons. Both contributedtremendously to their adopted stateand to the life sciences. When askedwhy they stayed, both stated Colorado’spioneering spirit, excellent researchfacilities and quality of life. They alsomentioned they were given theflexibility to conduct their jobs andresearch as they saw fit. Dr. Puck,reminiscing about the group ofscientists brought together from allover the world to develop thechromosome classification system in1960, recalls the day off he gave to theteam. He told them he would takethem anywhere they wanted to go andto his surprise they responded theywanted to go to Buffalo Bill’s grave westof Denver. Puck said that when thegroup drove up and stood over thegrave many of the scientists got teary-eyed. As Karen Auge’ states in herarticle in the Denver Post about Dr.Puck on June 15th, 2003, “to them,Colorado and Buffalo Bill representedthe freedom, openness and potential ofthe West.”

Dr. Caruthers had a similar story. In theearly 1980s when he was startingAmgen and Applied Biosystems, hewould conduct classes at CU in themorning then fly to California formeetings in the afternoon. He was ableto return to Boulder at the end of hisday for dinner with his family. In otherwords, Colorado gave them flexibilityand opportunity to be pioneers andgreat scientists within the confines of abeautiful and bountiful state.

Drs. Puck and Caruthers paved the wayfor others to follow. Drs. Carol andThomas Cech came to Coloradotogether in 1978. CU was the only

At ERI, Dr. Puck pioneeredthe study of toxicity in

chemotherapy andradiology by determining

the amount of x-ray dosageneeded to destroy cancercells. His research is the

basis for all radiation cancertreatment used today.

university that found two AssistantProfessor positions for these twooutstanding scientists and theflexibility to allow spouses to haveappointments in the same department.This was fortunate for the Cechs andColorado because Thomas Cechreceived the Nobel Prize for Chemistryeleven years later for his discovery thatRNA can catalyze chemical reactions.Over the last two years, Larry Gold,previously with CU’s Department ofMolecular, Cellular and DevelopmentalBiology, spun off EyeTechPharmaceuticals Inc., and SomaLogicbased on the SELEX method forgenerating diverse pools of moleculesdeveloped at the University ofColorado. CU researchers MichaelBristow and Leslie Leinwand co-founded Myogen, which went publiclate last year. These scientist and otherslike them have contributed enormouslyto Colorado’s biotech prowess.

Pioneers Puck and Caruthers came toColorado to pursue bioscience and start

related industries. Since then Coloradohas grown even more and continues tobe a hotbed for bioscience research anddevelopment. According to the 2003PriceWaterhouseCoopers MoneyTreeSurvey:

• Colorado companies outpaced therest of the country in raising venturecapital.

• The National Science Foundationranks Colorado first in funding as apercent of Gross State Product (GSP).

• Colorado ranked second in numberof new companies per 1,000 workers.

• Colorado ranked fourth for business starts per capita.

• Colorado ranked third in venturecapital as a share of GSP.

Clearly, Colorado is the best location ifyou are a bioscience scientist, start-upentrepreneur or business executive.Come participate in Colorado’s long,proud history of embracing its brave,creative pioneers. ◆

17

Washington, DC

New York

Baltimore

Northern Virginia

Miami

Los Angeles

Denver

Boulder

Colorado Springs

Berlin

Munich

Brussels

London

Paris

Budapest

Prague

Warsaw

Moscow

Beijing

Tokyo

Industry Depth. Global Reach. Market Leadership.In the rapidly evolving life sciences industry, companies face a broad spectrum of

complex legal issues. To address these demands, Hogan & Hartson has built an

integrated life sciences practice that extends beyond the traditional capabilities

offered by most other firms. Our comprehensive industry knowledge, extensive

global reach, and cross-disciplinary experience allow us to provide our clients with

seamless legal services across multiple borders.

Over the past 100 years, Hogan & Hartson has built a preeminent practice in

nearly every area of the law. With close to 1,000 attorneys and 20 offices around

the world, our full-service international practice cuts across virtually all legal

disciplines and industries.

The law firm for the life sciences industry.

www.hhlaw.com

T H E C O L O R A D O

A D V A N T A G E

Colorado has two of the world’sfastest supercomputers – at NOAAand NCAR.

Of ten biotechnology IPOs last year,two Colorado companies wentpublic. Myogen, Inc., and PharmionCorporation raised $73.3 millionand $76.2 million, respectively.

John G. Downs is the principal of Downs

Marketing, a Denver based business and

marketing consulting firm.

18

2www.amgen.com© 2004 Amgen. All rights reserved.

What if cancer patientscould avoid some of the debilitating side effects of their chemotherapy treatments?

They can.

What if rheumatoid arthritis sufferers were able to reduce their painful inflammation and regain many of their everyday routines?

They are.

What if health care providers had the power to simplify the treatment of anemia?

They do.

What if there was a company dedicated to delivering new human therapeutics that can dramatically improve people’s lives?

There is. It’s called Amgen.

2Dramatically Improving People’s Lives

by Victoria David

Colorado has

become one

of America’s

premier regions for

biotechnology,

pharmaceutical, bio-

agriculture, medical

device and many other

life science companies.

Due to the large

number of research

institutes, Colorado is

an attractive

geographic area for any

bioscience corporation

to consider when

selecting a location.

Institutes include the University ofColorado (CU), National Oceanic andAtmospheric Administration (NOAA),University Corporation of AtmosphericResearch (UCAR), National Center forAtmospheric Research (NCAR),University of Colorado Health SciencesCenter (UCHSC), Colorado StateUniversity (CSU), United StatesDepartment of Agriculture (USDA) andCenters for Disease Control (CDC).Colorado offers many facility and realestate options for companies wishing tolaunch research and developmentendeavors. Whether you need smallincubator lab space, midsize research anddevelopment facilities, pilot plant or stateof the art current Good ManufacturingPractice (cGMP) production space,Colorado has ample land available tomeet the needs of any company.

Colorado’s abundant labor andbusiness resources, when combinedwith vast amounts of affordable land,makes the state an obvious choice forbioscience companies wanting to locateto the highly desired central region ofthe United States. The state is knownfor its exceptional living, workingfamily environment and climate. Theseamenities comprise a surprisinglycompetitive and affordable alternativethat promises a far superior quality oflife than most other regions of the country.

The 127 mile Front Range of the RockyMountains is fast becoming a hotbioscience corridor and offers lifescience companies many locationoptions. To the north, Fort Collins is agrowing center for agri-science, animalhusbandry, infectious disease,biodefense and related research. In thecentral region, the Boulder/Longmontarea provides one of the highestconcentrations of life science,pharmaceutical, biotechnology,

research and development, and relatedmanufacturing and production facilitiesin the state.

Central Colorado, including metropolitanDenver, is home to a very impressive listof medical device and instrumentationcompanies. Metropolitan Denver offersFitzsimons, the first university affiliated“biopark” to be developed west of theMississippi and the newly proposed 160acre BioScience Center at the StapletonBusiness Park. Denver is also an energeticmetropolis that provides all of theattractions of a modern city, whilesupporting an extremely high quality oflife and an affordable standard of living.

In the southern region of the FrontRange, Colorado Springs provides anexcellent bioscience relocationalternative. The region has abundantsupply of land, quality facilities, a pro-business environment and a highlyskilled workforce.

In short, Colorado provides one of thecountry’s most attractive business,economic, cultural, social, financial andreal estate environments. The stateoffers an affordable environment wherelife science companies can thrive.Explore the many opportunities that arecurrently available for your company! ◆

Victoria David, AIA a principal at the

Maynard/David Partnership. Brian Mulvaney is the

National Coordinator of the CORFAC International

Life Sciences Group. Charlie Lodge focuses on

tenant representation at Bitzer Real Estate.

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B i o s c i e n c e C O L O R A D O

Bioscience Real Estate Opportunity in Colorado

T H E C O L O R A D O

A D V A N T A G E

#4 in number of patents issued per1000 workers.

Colorado companies outpaced therest of the country in raising venturecapital in 2003.

20

While many states are

newcomers to the

biotech industry,

Colorado has participated in

bioscience innovation for over

twenty years. The Centennial State

is home to many bioscience

companies and a well established

infrastructure which supports

continued growth. These resources

include premier medical and

research institutions, national law

and accounting firms, venture

capitalists and one of the most

educated workforces in the nation.

The Colorado Front Range is home to a number of venture capital firms investing in bioscience.Managing $410 million in capital, Sequel VenturePartners specializes in early stage funding fortechnology businesses in the Rocky Mountainregion. Morgenthaler Ventures, a national firmwith $850 million in its latest fund, has an officein Boulder focusing on new biotechnologyinvestments. Boulder Ventures, a national firminvesting their fourth fund in technologybusinesses, also has offices in Boulder.

In addition to funding sources, several preeminent nationaland local specialty law firms reside in Colorado. Someof the nation’s largest law firms have large patent andtrademark practices in Denver focusing on patentprosecution, licensing and enforcement. Firms specializingin high technology intellectual property, food and drug, and medical device law also maintain offices in Denver. In addition to top law firms, KPMG, Ernst & Young, and PriceWaterhouseCoopers have local offices that offeraccounting and management consulting services.

Colorado bioscience companies also have access to localmedical device, biotech and regulatory consultants that havedepth of expertise in medical device and biotechnology

Ready, Set, Grow!

Infrastructure forBiosciences inColorado

by Rhonda Wallen

T H E C O L O R A D O A D V A N T A G E

#1 in National Science Foundation funding as apercent of Gross State Product

#2 in number of new companies per 1,000 workers

#3 venture capital as a share of Gross State Product (GSP)

#3 in Small Business Innovative Research (SBIR) grantsawarded per worker

#4 business starts per capita

MoneyTree Survey, PriceWaterhouseCoopers

product development. In addition, the state’s economicdevelopment agencies have resources and strategies to assistcompanies as they expand or as they relocate to Colorado.

The Colorado bioscience community is represented by theColorado BioScience Association (CBSA), which works toadvocate for the industry on local and national legislativeissues. The CBSA regularly convenes the bioscience industrythrough networking, educational, and technical programsand events. On behalf of the industry, CBSA serves as a leadagency in implementing initiatives identified in the 2003“Action Plan to Grow Colorado’s Bioscience Cluster.” Theseinitiatives include workforce, communications, technologytransfer, financing, and related business climate issues. ThePlan was commissioned by the Governor’s Office and servesas a focal point to mobilize resources and actions to promotethe growth of the industry.

Experienced and dedicated incubation facilities andresources are also available to start-up companies inColorado. They are: CTEK Colorado with offices in Boulderand Longmont, Virtual Incubator located in Fort Collins andthe Bioscience Park at Fitzsimons serving Denver/Aurora

start-ups. In addition, the Rose Biomedical DevelopmentCorporation provides comprehensive business support to earlystage companies with promising medical device technologies.

Colorado’s research base, funding sources, professionalservices, workforce and industry associations, along with thecommitment of state and local governments, work inconcert to enable bioscience companies to expand and growin Colorado. With all of these elements in place it is nowonder that Colorado’s Governor, Bill Owens declared,“Biotech grows best at high altitude.” ◆

Rhonda Wallen is a Partner at Signet BioVentures in Boulder, Colorado.

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B i o s c i e n c e C O L O R A D O

5420 Ward RoadArvada, Colorado 80002

P A R T N E R S H I P , I N C

303.420.2119 Pwww.maynarddavid.com

Architecture, planning & design for research technology

G L O B A L

B I OT E C H

L E G A L

E X P E RT I S E

MUNICH SAN FRANCISCO DENVER SALT LAKE CITY LONDON PARIS DUBAI

www.hro.com www.dentonwildesapte.com

Dominic A. Lloyd

303.866.0474

22

Fitzsimons’ collaborative synergy comes from the integrationof many outstanding and nationally recognizedinstitutions/elements, including the University of ColoradoHealth Sciences Center (UCHSC), University of ColoradoHospital (UCH), the Fitzsimons Redevelopment Authority(FRA) and its Colorado Bioscience Park Aurora, TheChildren’s Hospital and the potential of the VeteransAdministration/Department of Defense (VA/DOD) FederalTower. Bringing these important entities together will improveresearch collaborations, clinical care and the transfer of ideasand advances from the laboratory to the hospital bedside.

For the University of Colorado (CU), the Fitzsimonsopportunity came from the pressing need in the mid-1990sto expand its research and clinical facilities. The crowded

campus at East Ninth Avenue and Colorado Boulevard inDenver presented no potential for growth. As CU lookedbeyond the boundaries of the congested 46-acre campus, theFitzsimons Army Medical Garrison in Aurora was being put onthe Federal Government’s Base Realignment and Closure list.

Through a public benefit conveyance, CU received 227 acresof the 578-acre Fitzsimons site. That generous parcel of landnow houses the new and rapidly growing campus of theUCHSC, slated for initial phase completion by 2007-2008.This first phase of the master-planned campus is estimatedto cost $1.3 billion – $ 750 million for UCHSC and $550million for UCH. In addition, The Children’s Hospital andthe VA/DOD will invest an estimated $452 million and $300million, respectively.

Within the city of Aurora, Colorado, another city is being

built—from the ground up, called Fitzsimons. This “city

within a city” is the largest medically related health sciences

development in the nation and is called Colorado’s “square mile of life

sciences.” By fostering amazing collaborative opportunities in research,

education, patient care and community service, this visionary life sciences

city promises to revolutionize healthcare and the bioscience industry.

FITZSIMONSA Life Sciences Community for the Future by Mitzi Schindler

To date, more than 1.6 million gross square feet of the newCU-Health Sciences Center and University of ColoradoHospital campus is completed with another nearly 2 milliongross square feet under construction or in design phase.More than $1 billion of the $1.3 billion funding for theproject has already been committed. Funding to move thetwo institutions is coming from several sources, includingfederal and state monies, loans and private gifts.

Adjacent and affiliated to this burgeoning academic medicalcampus is the 160-acre Colorado Bioscience Park Aurora.This research park will foster the commercialization of theinnovations occurring on campus. Eighteen biosciencecompanies have already located in the research park.

The implications of the “square mile of life sciences” areastounding. Economic predictions alone estimate that by2010, Fitzsimons will support more than 19,000 direct long-term jobs, another 23,000 indirect induced jobs andgenerate more than $55 million of state corporate andpersonal income, sales taxes and motor vehicle registrationfees. Local sales and use taxes are expected to be $25million. By 2010, economic activity spurred by theFitzsimons site is expected to be $3.1 billion.

In addition to the positive economic implications of theFitzsimons project, the scientific implications related toeducation, research, patient care and biotechnology arestaggering. With the nationally recognized UCHSC/UCHfaculty, staff and administrators, Fitzsimons offers not onlythe much needed room for expansion of research labs,patient care facilities and schools, but it also allows anunprecedented opportunity to re-conceptualize how theinstitution’s mission and goals are met.

When the 600,000 gross square feet Research Complex 1opens in June 2004, approximately 1,500 researchers andsupport staff will move into the 241 labs. In addition, theadjacent research facilities of the Colorado Bioscience ParkAurora create an incredible opportunity for public/privatepartnerships to take research discoveries from bench tobedside at an accelerated rate. According to a report by theconsulting firm Ernst & Young, Colorado’s biotechnologyindustry is experiencing skyrocketing growth rates that faroutpace other states.

Formal programs and informal daily encounters facilitatecollaborations at Fitzsimons. Facilities, services and supportgive start-up and early stage bioscience companies the bestpossible opportunities to succeed. An affiliation agreementprovides research park companies special consideration foraccess to university core labs and services. New buildingsand development parcels in the research park can also

accommodate expansion-stage bioscience companies andpharmaceutical R&D operations within the campus setting.

From another perspective, Fitzsimons will truly be a “citywithin a city,” by incorporating a town center, theFitzsimons Commons. This centrally located retail hub willaccommodate workers, visitors and students on site.Amenities will include restaurants and retail stores,approximately 500 market-rate apartment units and a lightrail stop connecting Fitzsimons to Denver InternationalAirport, downtown Denver, and the Denver Tech Center. Inaddition, the site will include a hotel/conference facility,Class A office buildings and a City of Aurora Police station.

The Fitzsimons development is an amazing vision. The futureof biomedical research, health professional education and21st-century patient care are turning that vision into reality. ◆

Mitzi Schindler is the Director of Communications at the Fitzsimons

campus of the University of Colorado Health Sciences Center (UCHSC) .

23

B i o s c i e n c e C O L O R A D O

2004C O L O R A D O

B I O S C I E N C E

D I R E C T O R Y

24

25

Index

26 Research Institutes

29 Bioscience Companies• Biotechnology/Pharmaceutical • Medical Device

40 Bioscience Resources

26

The University of Colorado Boulder, Denver, Health Sciences Center, and Colorado Springswww.cu.edu/techtransfer/

The University of Colorado (CU) capitalizes on its wealth of basic researchexpertise and facilities to support biotechnology collaborations across itsfour campuses. The Colorado Springs Campus is notable for expertise inmetabolics and the Denver Campus for a strong computational biologyprogram via the Center for Computational Biology.

At the University of Colorado the primary contributors to research in thebiotechnology sector are the Boulder Campus and the Health SciencesCenter in Denver (UCHSC). In 2003, CU raised over $530 million insponsored research funding. The UCHSC is relocating to the Fitzsimonscampus along with the University of Colorado Hospital, The Children’sHospital, and numerous other centers and institutes such as the Webb-Waring Institute and the Barbara Davis Center for Childhood Diabetes.

Colorado State UniversityFort Collins www.csurf.org

Colorado State University (CSU), a regional and national leader in scientificdiscovery, generated approximately $200 million in sponsored researchactivities in fiscal year 2004. CSU is designated by the CarnegieFoundation as being in the highest level of research classification:“Doctor/Research Universities – Extensive.” CSU boasts strong programs inveterinary medicine, biotechnology, engineering, agriculture, and naturalresources.

The CSU Center for Advanced Technology currently houses and attractscompanies interested in collaborating with the university. It provides aphysical location for companies and fosters mutually beneficialrelationships between CSU’s research programs and private industry. TheCenter is home to the Natural Resources Research Center campus wherenearly 1,000 federal employees work. The James L. Voss VeterinaryTeaching Hospital is also directly adjacent to the Center.

University of DenverDenver www.du.edu

University of Denver (DU) is the oldest independent university in theRocky Mountain region. The Carnegie Foundation classifies DU as“Doctoral/Research University–Extensive.” DU significantly enhanced itsbase of science research with the addition of the Eleanor RooseveltInstitute in 2003.

Colorado School of MinesGolden www.mines.edu

Colorado School of Mines (CSM) is a public research universityinternationally recognized for its leadership in engineering, applied scienceand related disciplines, with a special emphasis on the Earth and itsresources.

University of Northern ColoradoGreeley www.unco.edu

University of Northern Colorado (UNC) is a multipurpose institution with awide range of graduate and undergraduate programs. The university’smission is to prepare individuals for advanced study, professional careers,and positions of leadership.

National Jewish Medical and Research CenterDenverwww.nationaljewish.org

National Jewish Medical and Research Center, the number one respiratoryhospital in the United States, is also one of the most successful andinfluential independent biomedical research centers in the world. Morethan 100 faculty members conduct basic, translational, and clinicalresearch in areas related to immunology, respiratory medicine, allergy,cancer, cell and molecular biology. National Jewish receives more than $45million in sponsored research support annually, and is among the top fivepercent of all institutions of all types receiving research support from theNational Institutes of Health. Our success rate in grant applications to theNIH exceeds the national average by 19 percent. National Jewish ranks in thetop 15 institutions worldwide for the impact of its research papers in the fieldsof Molecular Biology and Genetics, and Biology and Biochemistry. NationalJewish researchers have been credited with several groundbreaking discoveries,including the IgE molecule, the T cell receptor, and superantigens.

National Jewish has also made substantial progress in growing anintellectual property portfolio and commercializing the discoveries of itsworld-class scientists. National Jewish manages a technology portfolio ofmore than 100 inventions and owns more than 50 issued US patents. Ithas entered into technology-related license agreements with 63 companiesin the last 10 years, eight of them start-ups.

The Colorado BioScience Association (CBSA) is theindustry organization for medical device,biotechnology, pharmaceutical, and agriculturalbiotechnology companies in Colorado. With over 250members, the CBSA is a vital organization thatconvenes the industry through over 40 events andprograms during the year. The Association advocateson behalf of the industry to create an optimal businessclimate for bioscience in Colorado. Importantpartnerships with research institutions, public agencies,economic development agencies and other businessorganizations are developed through CBSA’s work oninitiatives of critical importance to the industry.

For information contact:Denise Brown

Executive Director, CBSAdbrown@colobio.com

12635 East Montview Boulevard • Aurora, CO 80010 ph: 720-859-4153 • fax: 720-859-4110

www.CoBioScience.com

Research Institutes

Denver Veterans Administration Medical Center Denverboris.draznin@med.va.gov

The Denver Veterans Administration Medical Center (VAMC) is nationallyand internationally recognized for its long and productive record ofconducting high quality basic science and clinical research. Over fortyDenver VAMC physicians and Ph.D. scientists annually conduct more than450 research studies with total research expenditures at over $17 million.Many VAMC scientists are internationally acclaimed experts in theirrespective fields. All scientists have academic appointments with theUniversity of Colorado Health Sciences Center.

The VAMC pioneered medical advances in liver transplantation and renaldialysis. Led by Drs. Robert Freedman and Sherry Leonard, today, theDenver VAMC houses the VA National Schizophrenia Research Center. ThisCenter explores genetic and molecular biology of certain brain processesinvolved in the development of this mental disease. The Federalgovernment funds VAMC Drs. Tyler, Heidenreich and Wierman to conductresearch in neurodegenerative disorders, such as Parkinson’s disease, andbrain development. Also, the VMAC manages nineteen national co-operative studies or multi-center clinical trials. One of them, examiningvital aspects of coronary artery bypass surgery, has its nationalcoordinating center in Denver.

University of Colorado Hospital Denver www.uchsc.edu

As the flagship teaching and research hospital in the Rocky Mountain Region,the University of Colorado Hospital advances health knowledge throughresearch and patient care. Strong research programs in immunology, cancer,neurosciences, drug and alcohol addiction, and in all areas of biomedical

science are evidenced by over 3,000 approved clinical trials.

The Children’s Hospital Research Institute Denverwww.uchsc.edu/peds/research/ri/

The Children’s Hospital Research Institute (TCHRI) consistently rates as oneof the country’s top ten percent federally funded pediatric researchprograms. TCHRI has achieved many firsts, including performing pediatricliver transplants, intrauterine surgery, identifying causes of toxic shocksyndrome, using nitric oxide for pulmonary hypertension, and describingchild abuse medical consequences. Current research focuses includedevelopmental biology, obesity, outcomes research, experimentaltherapeutics and clinical trials organization.

Eleanor Roosevelt Institute at the University of DenverDenverhttp://www.nsm.du.edu/eri/

The Eleanor Roosevelt Institute (ERI) was founded on the belief thatbiomedical and genetic research is the most effective, long-term approachto the eventual conquest of human disease. The ERI has been at the centerof genetic research since 1961. An ERI scientist, Dr. Theodore Puck, aliving legend in the field of genetics and biomedical research, createdsomatic cell genetics, introduced the human cell growth culture incubatortechnique, and organized the creation of the classification system bywhich all scientists study chromosomes. Many of Dr. Puck’s discoveriesmake modern molecular genetics possible. ERI’s research accomplishmentscontinue with the sequencing of chromosome 21, developing the mostsensitive environmental agent toxicity test, determining the lethal levelsof x-rays for human cells and participating in the discovery of genesrelated to colon cancer, Lou Gehrig’s disease, leukemia, heart disease andAlzheimer’s disease.

B i o s c i e n c e C O L O R A D O

27

AMC Cancer Research Center Lakewood www.amc.org

AMC is a national, not-for-profit research institute dedicated to theprevention and control of cancer and other chronic diseases. AMC isconducting innovative and important research in the areas of cancercausation and prevention, behavioral research, nutrition, clinical andcommunity studies and health communication.

Laboratories At Bonfils Denver www.bonfils.org

Laboratories At Bonfils has earned a national reputation as a referencetesting lab in core areas of transplant immunology, infectious diseaseserology and microbiology, offering more than 400 tests. These labs areaffiliated with the nationally renowned Bonfils Blood Center.

Division of Vector-Borne Infectious Diseases Fort Collins www.cdc.gov/ncidod/dvbid/

Division of Vector-Borne Infectious Diseases is part of the Centers forDisease Control and Prevention (CDC). The CDC is recognized as the leadfederal agency for protecting the health and safety of people at home andabroad. The Division of Vector-Borne Infectious Diseases serves as anational and international reference center for vector-borne viral andbacterial diseases.

National Renewable Energy Laboratory – National Bioenergy CenterGoldenhttp://www.nrel.gov/biomass/

The National Bioenergy Center, housed at the National Renewable EnergyLaboratory (NREL), develops biological, chemical, and thermochemicaltechnologies that produce economic and environmental sensitive fuels,chemicals, fibers and plastics from grasses, trees, organic wastes and otherrenewable biomass resources. The Center cooperates with private industry,National Renewable Energy and Department of Energy laboratories todevelop profitable “biorefinery” business models based on this newtechnology.

National Institute of Standards and TechnologyBoulder www.nist.gov

The National Institute of Standards and Technology (NIST) is a non-regulatory federal agency that operates eight different science andadvanced technology research divisions in Colorado. Celebrating a fifty-year legacy, NIST’s list of research accomplishments includes a NIST seniorscientist winning the Nobel Prize in 2001 for creating the world’s first“Bose-Einstein condensate.” In 2003, another NIST scientist won aMacArthur Fellowship for discovering a new quantum gas and was namedby Science as one of the top ten scientific advances of the year. Currentresearch focuses on single molecule manipulation that has future forensicresearch and DNA testing applications.

United States Geological Survey - Center for Biological Informaticshttp://biology.usgs.gov/cbi/

The Center for Biological Informatics, at the Denver Federal Center, operatesthe National Biological Information Infrastructure (NBII). This is the firstcomprehensive electronic gateway dedicated exclusively to biologicalscience data and information from sources throughout the world.

28

BIOTECHNOLOGY/PHARMACEUTICALAccelr 8 Technology Corporation www.accelr8.comDenverAccelr 8 Technology Corporation's proprietary surface chemistry and itsquantitative instruments support real-time assessment of medicaldiagnostics, food-borne pathogens, water-borne pathogens and bio-warfareassessments.

Accera, Inc. www.accerapharma.comBroomfieldAccera, Inc., pursues new therapeutic approaches to the treatment andcure of Alzheimer’s Disease based upon neuronal cell energy metabolism.The Company’s products and services evolve from its proprietarymetabolism platform.

Advanced Nutraceuticals, Inc. www.advancednutraceuticals.comDenverAdvanced Nutraceuticals, Inc., manufactures capsule form blended vitaminsand nutritional supplements plus liquid and powder pharmaceuticalproducts.

Affinity Bioreagents, Inc. www.bioreagents.comGoldenAffinity BioReagents offers primary and secondary antibodies, proteins,peptides and viral expression kits. The Company also creates customantibodies to meet specific research needs.

Agripro Wheat www.agriprowheat.comBerthoudAgriPro Wheat leads the way in the development and delivery of superiorwheat seed genetics in North America.

Allos Therapeutics, Inc. www.allos.comWestminsterAllos Therapeutics, Inc., develops small molecule, non-protein drugs forimproving cancer treatments. By increasing tumor oxygenation, theCompany’s products enhance the efficacy of standard radiation therapy andcertain chemotherapeutic drugs.

AlloSource www.allosource.orgEnglewoodAlloSource responsibly develops, processes and distributes life-enhancingbone and tissue allografts to the medical community.

Alpharma, Inc. www.alpharma.comLongmontAlpharma Inc., is the largest manufacturer of generic liquid and topicalpharmaceuticals in the U.S. The Company is also one of the largestsuppliers of generic pharmaceuticals in selected European markets.

American Allied Biochemical, Inc. www.aablabs.comAuroraAmerican Allied Biochemical, Inc., specializes in the purification anddistribution of restriction endonucleases.

Amgen, Inc. www.amgen.comLongmontAmgen, Inc., is a global biotechnology company that discovers, develops,manufactures and markets human therapeutics based on advances incellular and molecular biology.

Amidex, Inc. www.amidexmedical.comLakewoodAmidex, Inc., manufactures the Amilyser™, which collects non-volatileaerosols from exhaled breath and produces the first result within fiveminutes, then continues to monitor breathing circuits to provide time-resolved trends of analytes.

Animal Health Options www.animalhealthoptions.comGoldenAnimal Health Options offers high quality nutritional supplements thatmeet or exceed industry standards and provide a noticeable benefit todogs, cats and horses.

Aquatic BioSystems, Inc. www.aquaticbiosystems.comFort CollinsAquatic BioSystems, Inc., grows and distributes freshwater and marineorganisms for aquatic toxicology, biomonitoring and other researchactivities.

ARCA Discovery michael.bristow@uchsc.comAuroraARCA Discovery conducts contract research specialized inbiopharmaceutical drug development in the field of heart failure.

Array Biopharma, Inc. www.arraybiopharma.comBoulderArray BioPharma integrates the latest advances in chemistry, biology andinformatics to create orally active drugs for cancer and inflammatorydisease. Array also collaborates with others to invent and optimize drugcandidates across many therapeutic areas.

AspenBio, Inc. www.aspenbioinc.comCastle RockAspenBio, Inc., develops proprietary products to the point of introductionand then seeks pharmaceutical company partners. Current candidatesinclude human and animal proteins and hormones.

Atrix Laboratories, Inc. www.atrixlabs.comFort CollinsAtrix Laboratories, Inc., with five patented drug-delivery technologies, isdeveloping a portfolio of products for oncology, dermatology, painmanagement and growth hormone releasing applications.

Aurogen, Inc. www.aurogen.comFort CollinsAurogen, Inc., offers newly patented pharmaceutical treatment for diabeticneuropathy.

Avidity www.avidity.comDenverAvidity holds exclusive rights to the patented biotin-accepting peptides(AviTag) technology that exploits the tight interaction of avidin orstreptavidin with biotin for immobilizing, purifying and visualizingproteins.

Barafold, Inc. lhesterber@aol.comAuroraBarofold, Inc., acquired exclusive rights to a patented protein dis-aggregation and re-folding technology invented by Drs. Randolph andCarpenter at the University of Colorado in May 2003.

Biologixs, Inc. jnathanson@biologixs.comDenverBiologixs, Inc., breeds insects for pest control.

BioResponse LLC www.bioresponse.comBoulderBioResponse is an innovator and leader in nutrient delivery technology.Most recently, BioResponse was awarded a patent for its delivery systemfor highly-absorbable (“bioavailable”) Diindolylmethane.

Bioscience Companies

29

30

Blue Sun Biodiesel www.gobluesun.comFort CollinsBlue Sun Biodiesel produces high-performance biodiesel fuel from oilseedenergy crops well-adapted to the hot, arid growing conditions of the HighPlains.

Boulder Scientific Co. www.bouldersci.comMeadBoulder Scientific produces pharmaceutical intermediates, metallocenes,boron compounds and custom chemicals.

Brotica, Inc. www.brotica.comFort CollinsBrotica produces Interval 33 a termite attractant based on patent pendingtechnology developed at Colorado State University.

CAP Biotechnology, Inc. www.capbio.comGoldenCap Biotechnology, Inc., produces calcium phosphate hollow microspheresand custom shaped calcium phosphate materials useful for tissue banksand research applications.

Cardinal Health www.cardinal.com/npsGoldenCardinal Health offers the latest in imaging agents andradiopharmaceutical containers for the nuclear pharmacy.

CeMines www.cemines.comEvergreenCeMines developed its breakthrough Molecular FingerPrinting™ blood testfor the early-detection of a variety of cancers and other immune diseases.

Chemins Company, Inc. www.chemins.comColorado SpringsChemins produces a wide range of dietary supplements including caplets,tablets, shaped tablets, chewable wafers, two-piece capsules and powderedproducts.

Colorado Genetics, Inc. www.coloradogenetics.comLovelandColorado Genetics Inc., provides livestock embryo-transfer research,artificial insemination, embryo collection, freezing and transfer,international import and export services.

Colorado Serum, Inc. www.colorado-serum.comDenverColorado Serum, Inc., supplies veterinary biologicals, instruments,laboratory reagents and serums for the veterinary industry.

Cytoskeleton, Inc. www.cytoskeleton.comDenverCytoskeleton supplies pharmaceutical services, drug discovery and contractservices.

DakoCytomation Colorado www.dakocytomation.comFort CollinsDakoCytomation designs and manufactures high-performance cell analyzersand sorters for use in biomedical research.

Dharmacon, Inc. www.dharmacon.comLafayetteDharmacon develops 2'-ACE RNA and other RNA oligo-dependentapplications and technologies. Dharmacon technology is superior to allother synthesize RNA products currently on the market.

DMI Biosciences, Inc. www.dmibiosciences.comEnglewoodDMI BioSciences, Inc., develops small molecule, peptide-basedpharmaceuticals and biomarkers for acute and chronic inflammation.

DNA-IntelliGen Corporation benmorales@adelphia.netMonumentDNA IntelliGen develops and applies current biometric technology intosecurity products designed to thwart identity theft, to provide more robustpersonal security and to secure financial transactions.

Efficas, Inc. www.efficas.comBoulderEfficas is an early stage biotechnology company that discovers and marketsnatural bioactives destined for inclusion in functional and medical foods,dietary supplements, pet products and cosmeceuticals.

ELISA Tech www.elisatech.com AuroraELISA Tech supplies immunoassays for the measurement of cytokines,growth factors and lipid inflammatory mediators such as prostaglandinsand leukotrienes.

Emergent Genetics, Inc. www.emergentgenetics.comBoulderEmergent Genetics is a seed and biotechnology company with operations inthe U.S., Europe and India that strategically focuses on cotton, rice, wheatand vegetables.

Evergreen Research, Inc. www.evergreenresearch.comGoldenERI performs contract product development with an emphasis on medicaldevices.

Evolutionary Genomics www.evolgen.comAuroraEvolutionary Genomics (EG) has developed a unique, cost-effective fullyoperational, patented, gene discovery technology platform, named theAdapted Traits Platform. EG has been successfully identifying genes forfour years.

Gene Check, Inc. www.genecheck.comFort CollinsGene Check produces reagents and kits for research and offers veterinarygenotyping tests for animals.

Genethera, Inc. www.genethera.comWheatridge GeneThera, Inc., provides genetics-based diagnostic and vaccine solutionsto meet the growing demands of today's veterinary industry and tomorrow'sagriculture and healthcare industries.

Genetic Technologies Limited www.gtg.com.auFitzroyGenetic Technologies focuses its research efforts on the non-coding DNAsequences of the human HLA Gene complex to improve the survival rates ofbone marrow transplants and other future cellular transplants from onehuman donor to another human recipient.

Global Peptide Services LLC www.globalpeptide.comFort CollinsGlobal Peptide Services offers peptides from 70% purity up to greater than95% HPLC purity with a quality guarantee.

Globelmmune, Inc. www.globeimmune.comAuroraGlobeImmune. Inc., is currently developing products to treat HIV, hepatitisC, and a number of cancers that traditionally were unapproachable.Company’s products are based on its immunotherapy platform technology.

Gonex, Inc. www.instantweb.com/p/pjarosz/index.htmBoulderGonex develops compounds that pharmaceutically sterilize any animal withone injection. From this research, the company is investigating treatmentof hormone sensitive cancers in humans such as prostate and breastcancers.

Gynelogix, Inc.LouisvilleGynelogix, Inc. is currently in clinical trails for vaginal suppositories totreat recurrent urinary tract infections in women.

Hauser Laboratories www.hauserlabs.comBoulderHauser Laboratories provides testing services to the pharmaceutical,natural products, dietary supplement, medical device, legal and insurance,consumer and industrial industries.

HemoGenix www.hemogenix.comColorado SpringsHemoGenix is paving the way with new, innovative, and novelbiotechnology to reduce toxicity and improve efficacy of cancertherapeutics.

Heska Corporation www.heska.comFort CollinsHeska produces vaccines, dietary supplements, allergy medications andmedical devices for the veterinarian market. The Company has alsoinitiated clinical trials designed to assess the ability of a gene-basedtherapy to cause remission of soft tissue sarcomas and oral melanomas indogs.

Hirsh Precision Products, Inc. www.hppi.comBoulderHirsh Precision Products, Inc., manufactures components that repeat andhave stringent cosmetic and dimensional requirements. Industries servedinclude Medical, Automotive, Communications and Instrumentation.

IHCtech Histology Services pruegg@msn.comAuroraIHC t e c h offers quality tissue preparation and histology services.

Innovative Histology elizabeth.smith@ushsc.eduAuroraInnovative Histology specializes in tissue processing for un-decalcifiedtissues and bone.

International Approvals Laboratories (IA Labs) www.ialabs.comBoulderIA Labs is the leading Electromagnetic Interference and ElectromagneticCompatibility testing laboratory in the Rocky Mountain region.

Invenux, Inc. www.invenux.comDenverInvenux, Inc., utilizes its Evolutionary Chemistry™, an integrated drugdiscovery process, to accelerate drug discovery by selecting the mostpromising leads from among millions of compounds.

Ischemia Technologies www.ischemia.comArvadaIschemia Technologies researches, designs, manufactures and distributesproducts that help identify the presence of Ischemia in patients with chestpain in hospital emergency rooms. The Company’s products are in vitro-diagnostic markers.

Isogenis, Inc. www.isogenis.comDenverIsogenis, Inc., develops revolutionary therapies for organ transplantationand genetic disease. Its Transplantation TreeTM technology facilitates theengraftment of foreign tissues, organs, and gene products in a manner lesstoxic to the patient.

Johnson and Johnson www.jnj.com/homeJohnson & Johnson operating companies manufacture and marketthousands of products that cover a wide range of diseases and conditions.

Kerr Group, Inc. www.kerrgroup.comDenverKerr Group, Inc., leads the child-resistant and tamper-evident closureindustry. The Company has strong market positions in the pharmaceutical,prescription drug and distilled spirits industries.

Keystone Biomedical, Inc. www.keystonebio.comWestminsterKeystone Biomedical, Inc., is engaged in advancing its Bucillamine andExochelin product platforms for the treatment and prevention ofcardiovascular disease.

Kimball Genetics, Inc. www.kimballgenetics.comDenverKimball Genetics, Inc., is nationally recognized for genetic consultation.

Laboratories At Bonfils www.labsatbonfils.comDenverLaboratories At Bonfils (L.A.B.) focuses on performing complex, esotericassays. L.A.B.’s desires to be the market leader in laboratory testing forinfectious disease markers, microbiology and immunogenetics.

Macleod Pharmaceuticals, Inc. www.macleodpharma.com Fort CollinsMacleod Pharmaceuticals, Inc., produces UNIPRIM” Powder an oral equinebacterial infection treatment.

Martek Biosciences Corporation www.martekbio.comBoulderMartek Biosciences Corporation manufacturers and sells products developedfrom microalgae.

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Mayne Pharma, Inc. www.maynepharma.com/usBoulderMayne Pharma, Inc., a Mayne Group Limited Company , is a supplier ofmulti-source injectable pharmaceuticals.

Mediral International, Inc. www.mediral.comDenverWith over 3,000 mother tinctures and ingredients in stock, MediralInternational Inc., provides the highest quality natural products tohealthcare professionals.

Medivance, Inc. www.medivance.comLouisvilleMedivance’s patented Arctic Sun Temperature Management Systemrepresents a new generation of noninvasive and safe temperaturemanagement systems.

MicroPhage Incorporated www.micro-phage.comBoulderMicroPhage manufactures patented high-speed bacteria detectiontechnologies with applications in the food, water and environmentcontamination, human and animal infectious agent evaluations, industrialpathogens and biological warfare.

Molecular Biosciences, Inc. www.molbio.comBoulderMolecular Biosciences, Inc., is a major, domestic manufacturer of productsused primarily to investigate cellular function and homeostasismechanisms.

Monsanto www.monsanto.comEnglewoodMonsanto Company, together with its subsidiaries, is a global provider ofagricultural products and integrated solutions for farmers.

MycoLogics, Inc. claude.selitrennikoff@uchs.eduAuroraMycoLogics, Inc., focuses on infectious human fungal diseases. Thecompany's mycotechnology will be used to discover novel drugs that act bydirectly inhibiting fungal cell-wall assembly.

Mycos Research, LLC www.mycosresearch.comFort CollinsMycos Research provides mycobacterial derived biochemicals to theresearch community, animal models for tuberculosis and other BSL3organisms, and novel mycobacterial infection monitoring and vaccineproducts.

Myogen, Inc. www.myogen.comWestminsterMyogen, Inc., is a biopharmaceutical company focused on the discovery,development and commercialization of small molecule therapeutics for thetreatment of cardiovascular disorders.

NaPro BioTherapeutics, Inc. www.naprobio.com BoulderNaPro BioTherapeutics, Inc., develops and licenses anti-cancer agents andoffers genomic therapies based on its proprietary gene editing technology.

Newellink, Inc. mnewell@uccs.eduColorado SpringsNewellink, Inc., with its multidisciplinary platform approach tounderstanding cellular metabolism and cellular communication, willproduce or license biopharmaceuticals to treat or cure major diseases.

Novus Biologicals, Inc www.novus-biologicals.comLittletonNovus Biologicals, Inc., carries an extensive line of monoclonal andpolyclonal antibodies for the study of DNA repair, cancer, neuroscience,lipid, circadian rhythm, apoptosis and other research areas.

Nurture, Inc. www.nurture-inc.comDenverNurture, Inc., develops and markets a proprietary technology that produceshigh value-added ingredients derived from oats and other cereal grains.

Nutraceutix, Inc. www.nutraceutix.comLafayetteNutraceutix, Inc., manufactures probiotics, develops proprietary nutritionalproduct formulations, and offers specialty nutraceutical ingredients,including several that utilize CDT™ technologies.

Origin USA, LLC www.originpharm.comBoulderOrigin USA offers expert support in regulatory affairs, project managementand strategic drug development, soon to be joined by clinical servicesfocused on early-phase development.

OSI Pharmaceuticals, Inc. www.osip.comBoulderOSI Pharmaceuticals, Inc., focuses on the discovery, development andcommercialization of high-quality, next-generation oncology products thatboth extend and improve the quality-of-life for cancer patients around theworld.

Paxis Pharmaceuticals, Inc. www.paxispharma.comBoulderPaxis Pharmaceuticals, Inc., produces Paclitaxel under FDA approved GMP's.Paclitaxel is the leading chemotherapy drug in the U.S. market for thetreatment of Breast and Ovarian cancers.

Pfizer, Inc. www.pfizer.comCentennialPfizer Inc., is a research-based, global pharmaceutical company. TheCompany discovers, develops, manufactures and markets prescriptionmedicines for humans and animals, as well as many consumer products.

Phaelixe Healthcare Resource phae@phaelixe.comCastle RockPhaelixe conducts custom research projects for the medical industry andspecializes in emerging medical technologies and startups, with currentfocus on imaging, nanobiotechnology, tissue engineering and telemedicine.

Pharmatech, Inc. www.pharmatech.comDenverPharmatech, Inc., is the only Research Management Organization in theindustry that manages pharmaceutical, medical device, biotechnology andpharmacoeconomic trials.

Pharmion Corporation www.Pharmion.comBoulderPharmion develops and markets hematology and oncology products thatexpands the therapeutic options available to healthcare providers and their patients.

Phasics BioScience, Inc. www.phasicsbio.comCastle RockPhasics BioScience, Inc., offers funded biotechnology companies processdevelopment services and scalable manufacturing facilities. The companyalso provides recombinant protein for preclinical and clinical trials oftherapeutic drugs.

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PhosphoSolutions Michael.Browning@uchsc.eduAuroraPhosphoSolutions focuses on phosphoproteins – the “verbs” of theproteomics language. The company produces and distributes customphosphospecific antibodies for research, diagnostic and therapeuticapplications.

Pisces Molecular www.pisces-molecular.comBoulderPisces Molecular offers fish based health and biotechnology products.

PR Pharmaceuticals www.prpharm.comFort CollinsPR Pharmaceuticals is an innovative drug delivery company whose productPRP™ is a sophisticated, controlled-release technology for human andanimal applications.

Premier Histology Laboratory, LLC www.premierhistology.comBoulderPremier Histology provices histological services to pharmaceutical andbiotechnology researchers studing the performance of therapeutic agents.

Pro-Safe Products www.prosafeproducts.comGrand JunctionPro-Safe Products offers a complete line of infection control products forthe dental and medical specialties.

Progenity, Inc. www.progenity.comDenverProgenity, Inc., is a custom Contract Manufacturing Organization thatsupplies high-quality protein-based therapeutics to the biopharmaceuticalindustry.

Proligo LLC www.proligo.comBoulderProligo manufacturers DNA and RNA oligonucleotides and other specialtyproducts to meet your research needs.

Pyxant Labs, Inc. www.pyxant.comColorado SpringsPyxant Labs, Inc., is a contract research laboratory specializing in GLPbioanalytical chemistry for life sciences clients.

Replidyne, Inc. www.replidyne.comLouisvilleReplidyne is a drug discovery company focused on identifying anddeveloping drugs to treat serious infectious diseases. Replidyne developsnovel antibacterial drugs that act by directly inhibiting bacterial DNAreplication.

RMC Software www.rmcsoft.comFort CollinsRMC Software offers expert services in the following areas: MolecularModeling, Computer Aided Drug Design, Protien-Ligand Docking Models,Drug Bioavailability Models, Drug Bioactivity Models and high-performancecomputing.

Roche Colorado Corp. www.rochecolorado.comBoulderRoche Colorado manufacturers bulk pharmaceutical intermediates andactive ingredients for prescription and over-the-counter medicines. Thesecompounds are sent to other manufacturing sites for formulation intofinished pharmaceutical products.

Rocky Mountain Biosystems, Inc. (RMBI) kmarchitto@biofusionary.comGoldenRMBI’s proprietary systems modify tissues for transdermal and depositiondrug delivery. Its Biofusionary™ subsidiary develops tissue fusiontechnology that closes surgical incisions without the use of sutures orstaples.

Rocky Mountain Reagents, Inc. www.rmreagents.comDenver

Rocky Mountain Reagents™, Inc., repackages large volume chemicals intoeconomical, functional product sizes. Offerings include titration reagents,indicators, acids, bases and other chemicals for life science research.

Rxkinetix, Inc. www.rxkinetix.comLouisvilleRxKinetix, Inc., is a specialty pharmaceutical company that usesproprietary drug delivery technologies to develop new medicinal products.

Sandoz, Inc. www.us.sandoz.comBroomfieldSandoz is one of the largest manufacturers of generic pharmaceuticalproducts in the United States.

Sentry Biosciences, LLC randy@swensonmanagement.comBoulderSentry Biosciences, LLC, is an emerging biosciences company thatdiscovers and develops compounds that regulate the process ofprogrammed cell death (apoptosis). Apoptosis has been implicated in fiftypercent of human diseases, including cancer, neurodegenerative disease,and autoimmune disease.

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Sirna Therapeutics www.sirna.comBoulderSirna Therapeutics is a leading developer of therapeutics based RNAinterference ( RNAi ) technology that selectively targets disease-causinggenes and viruses.

SomaLogic, Inc. www.Somalogic.comBoulderSomaLogic, Inc., develops proteomics tools based on its proprietaryaptamer technology to produce Aptamer chips that allow simultaneousprotein quantitative measurement and the rapid development of novelassays for individual proteins.

Source Precision Medicine www.sourcemedicine.comBoulderSource Precision Medicine is the first company to commercially introduce afully integrated, high-precision molecular system to precisely track diseaseand human therapeutic response at the cellular level.

STA Laboratories www.stalabs.comLongmontSTA Laboratories offers a wide range of seed quality testing services.

Toltec International, Inc. www.toltecint.comLakewoodToltec International, Inc., provides project management, real-timeembedded software and hardware services to medical device companies.

Touch of Life Technologies vic.spitzer@uchsc.eduAuroraTouch of Life Technologies is a early stage company that commercializesscientific applications based on advances in human anatomy simulation.

Transgenomic, Inc. www.transgenomic.comBoulderTransgenomic, Inc., provides products and services for the synthesis,purification and analysis of nucleic acids around three core competencies:separation chemistries, enzymology and nucleic acid chemistries.

Unigen Pharmaceuticals www.unigenpharma.comBroomfieldUnigen Pharmaceuticals is a leading supplier of proprietary naturalingredients. The Company also conducts natural products research anddevelopment.

Vitro Diagnostics, Inc. www.vitrodiag.comLittletonVitro Diagnostics’ VITROCELL™ product line consists of proliferating humancell lines suitable for diabetes, pancreatic cancer and endocrinology of thepituitary gland research.

Vitrolife, Inc. www.vitrolife.comEnglewoodVitrolife. Inc., develops, produces and markets a range of high-qualityproducts and systems for the preparation, cultivation, preservation andsupport of cells, tissues and organs.

Xtrana Inc. www.Xtrana.comBroomfieldXtrana, Inc., develops and commercializes technologies to simplify theanalysis of DNA and RNA, so that nucleic acid-based detection systems canbe utilized in point-of-care applications.

XY, Inc. www.xyinc.comFort CollinsXY, Inc., develops technologies for sex selection in animals. Using flowcytometry, sperm from breeding animals is sorted into X-chromosome, andY-chromosome bearing populations, allowing the selection of sex prior toartificial insemination or in-vitro fertilization.

ZeoponiX, Inc. www.zeoponix.comBoulderZeoponiX, Inc., has taken plant growth media based on NASA technologyand markets ZeoPro™ which is a combination growth medium/fertilizer/soilamendment. The Company has exclusive marketing rights to this NASAtechnology.

MEDICAL DEVICESAble Planet, Inc. www.ableplanet.comFort CollinsAble Planet's technology creates a wireless link between a hearing aid's T-coil and a phone or headset improving sound clarity for the hearingimpaired.

Aesthetic Technologies, Inc. www.parisianpeel.comBroomfieldAesthetic Technologies, Inc., produces Parisian Peel® Prestige™ MedicalMicrodermabrasion System which is a powerful but gentle anti-agingprocedure that exfoliates, refreshes and renews skin.

AgriHouse, Inc. www.agrihouse.comBerthoud AgriHouse, Inc., allows the grower in a controlled indoor environments toproduce high quality vegetables, gourmet plants and flowers in volume.

AKTIV-DRY www.aktiv-dry.comBoulder AKTIV-DRY provides dry powder processing solutions for the vaccine,pharmaceutical and biotechnology companies.

Allpro, Inc. www.allprodental.comBroomfieldAllpro, Inc., manufactures high quality dental products at an affordableprice.

Animark, Inc. www.animark.usAuroraAnimark Inc., has been a leader in the electronic breeding equipmentbusiness for over 30 years.

Applied X-Ray Technologies, Inc. www.huestismedical.comDenverApplied X-Ray Technologies, Inc., manufactures irradiation equipment.

Auri-Stim Medical, Inc. www.net1device.comDenverAuri-Stim Medical’s NET-I™ device produces electrical signals to electrodesconnected to the outer ear to treat patients for migraine, hormonal,chronic headaches, premenstrual syndrome, nicotine and narcoticsaddictions.

Baxa Corporation www.baxa.comEnglewoodBaxa was founded to focus on the needs of hospital pharmacists – fromthe pharmaceutical company to the patient – by facilitating the handling,packaging and administration of liquid medications.

Bell Dental Products LLC www.belldental.comDenverBell Dental Products designs, develops, and manufacturers precisionequipment based on electric motor technology for the aerospace, medical,and dental industries.

BioFeedback Systems, Inc. www.users.qwest.net/~pitchj/BoulderBio-Feedback Systems, Inc., is a high tech self-help medical devicecompany.

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Biotrol International www.biotrol.comLouisvilleBiotrol International, Inc., manufactures and markets effective surfacedisinfectants, instrument cleaners/disinfectants and vacuum line cleaningsystems for the dental professional.

Braun BioSystems www.braunbiosystems.comCentennialBraun BioSystems has developed and patented unique instrumentation anddisposable assay cartridges that address current point of care (POC)coagulation testing needs.

Byers Peak, Inc. www.byerspeak.comDenverByers Peak…a simple alternative. Specializing in electro-mechanical &medical contract manufacturing and other outsourcing Services.

CardioOptics, Inc. www.cardio-optics.comBoulderCardioOptics, Inc., invented and patented a method using Infrared (IR)light to see directly through flowing blood and examine the tissues andanatomical structures inside the heart and blood vessels.

Care Electronics, Inc. www.careelectronics.comBoulderCare Electronics, Inc., offers a range of safety alarms for monitoring innursing homes and home health care settings.

Caroba Plastics, Inc. www.caroba.comEnglewoodCaroba Plastics, Inc., is a full service custom injection molder specializingin the demanding needs of the medical and high technology industries.

Cavitat Medical Technologies www.cavitatmedtech.homestead.comAuroraCavitat Medical Technologies developed the worlds most advanced 3D colorimaging system for bone and the only ultrasound imaging system for theAlveolar process.

CEA Technologies, Inc. www.ceatechnologies.comColorado SpringsCEA Technologies, Inc., designs and manufactures over 1,000 types ofreusable and disposable medical devices.

Ceramed Dental LLC www.ceramed.comDenverCeramed Dental offers a complete line of superior products for surgical andreconstructive dentistry.

CeraPedics, LLC www.cerapedics.comLakewoodCeraPedics is an orthopedic company focused on developing osteobiologic(bone substitute) products using its proprietary small-peptide (P-15™)technology platform.

CIVCO Medical Instruments www.civco.comLongmont CIVCO Medical Instruments manufactures specialized medical products forultrasound and minimally invasive surgical equipment and procedures.

Cobe Cardiovascular, Inc. www.cobecv.comArvadaCOBE Cardiovascular, partnering with Sorin Biomedical, manufacturesoxygenators, cardioplegia systems, tubing packs, and biocompatiblesurfaces to heart/lung and autotransfusion systems.

Cochlear Americas www.cochlear.comEnglewoodCochlear is the world leader in cochlear implants and innovator of theNucleus® 3 cochlear implant system.

Coherent, Inc. www.coherentinc.comDenverCoherent, Inc., offers a diverse portfolio of laser systems, high power diodelasers, advanced laser diode modules and diagnostic equipment.

Colorado Histo-Prep www.histoprep.comFort CollinsColorado Histo-Prep prepares microscopic histology slides.

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Conception Technology, Inc. www.CTInews.comLongmontConception Technology, Inc., produces at-home biosensors for identifyingwomen's fertile days, fertility and birth control aids.

Confi-Dental Products Company www.confi-dental.comLouisvilleConfi-Dental Products manufacturers quality dental cements, compositeresins and injection-molded plastics. The company received the Governor’s2002 Award in the state of Colorado for Excellence in Exporting.

Corgenix Medical Corporation www.corgenix.comWestminsterCorgenix Medical provides innovative and quality medical diagnosticproducts for hemostasis, autoimmune and vascular applications.

Dairy Tech, Inc. www.dairytech.orgWindsorDairy Tech, Inc., develops and markets Reverse-Vat Pasteurizers designedspecifically for the dairy industry.

Datex-Ohmeda www.datex-ohmeda.comLouisvilleDatex-Ohmeda is the world's leading supplier of anesthesia equipment andrelated supplies and services. The Company offers anesthesia machines,patient monitors and ventilators. It also markets operating room, post-anesthesia care unit, intensive care unit and outside-the-hospital settingssupplies and accessories.

Denver Biomedical, Inc. www.denverbiomedical.comGoldenDenver Biomedical, Inc., is a leading designer, manufacturer anddistributor of specialized medical products for fluid management of pleuraleffusion and ascites.

Denver Instrument Company www.denverinstrument.comArvadaDenver Instrument Company is dedicated to providing affordable high-quality, precision instruments for the educational, laboratory and generalindustrial markets.

Discovery Partners International, Inc. www.xeno.comBoulderDiscovery Partners International, Inc., develops and sells instruments,products and services and related consumables to pharmaceuticalcompanies for chemical compound generation associated with drugdiscovery.

Eldon James Corporation www.eldonjames.comLovelandEldon James designs and manufactures plastic and stainless steel hosefittings with a superior single-barb design. Eldon James’ fittings are usedin many applications including medical, agricultural, food processing,biotech, laboratory, robotics and scientific instruments.

Encision, Inc. www.encision.comBoulderEncision, Inc., using patented active electrode monitoring technology,revolutionized minimally-invasive surgery with its AEM LaparoscopicInstruments.

Encynova International, Inc. www.encynova.comBroomfieldEncynova International, Inc., designs and markets the Encynova's Travcyl™Fluid Control System that delivers and controls fluids using a “travelingcylinder” pump design.

Fischer Imaging www.fischerimaging.comThorntonFischer Imaging is oldest existing manufacturer of x-ray medical equipmentin the country and leads the world in imaging solutions with a particularfocus on imaging and biopsy.

Gambro BCT www.gambrobct.comLakewoodGambro BCT is the global leader in automated blood collectiontechnologies, therapeutic apheresis and leukapheresis for cell therapyapplications.

Gambro, Inc. www.usa-gambro.comLakewoodGambro, Inc., is made up three business units – Gambro Renal Products,Gambro Healthcare and Gambro BCT. Respectively, these companies makedialysis products, operate dialysis clinics and supply blood banktechnology worldwide.

Genassist, Inc. www.genassist.comThe Genassist™ Concept is a service designed to assist you and your doctorto research, record and review your (and your partner's) family history forinherited conditions.

Genesee BioMedical, Inc. www.geneseebiomedical.comDenverGenesee BioMedical, Inc., manufacturers cardiac surgical devices and offersa complete line of sternal and valve retractors and disposable cardiacaccessories.

Hach Company www.hach.comLovelandHach Company provides advanced analytical systems and technical supportfor water quality testing for the lab, process and field.

Hamamatsu Corporation http://usa.hamamatsu.comBoulderHamamatsu Corporation develops and manufactures photo detectors, lightsources and optical components for medical and industrial applications.

Healthetech, Inc. www.healthetech.comGoldenHealtheTech, Inc., designs, develops and markets handheld medical devicesand software for the measurement and monitoring of important healthparameters.

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HEI Advanced Medical Operations www.heii.comBoulderHEI develops and manufactures high performance components, medicalsoftware, medical devices and non-medical products used for hearing andmedical applications, communications and high-speed data processing.

Ideatrics, Inc. www.ideatrics.comBoulderIdeatrics, Inc., develops hand-held manually-operated mechanicalinstruments and provides consulting services to organizations involved inthe design, manufacture and distribution of medical devices.

Inter-OS Technologies, Inc. www.inter-os.comLone TreeInter-Os Technologies, Inc., specializes in distraction osteogenesis anddevelops reputable devices that meet the needs of both patients andsurgeons.

Irom Imaging, Inc. www.irom.comEnglewoodIrom Imaging, Inc., develops mobile X-ray units, radiographic X-ray tables,and related ceiling, floor and wall suspended support systems.

JMST Systems Colorado SpringsJMST Systems manufactures innovative, high quality, cost effectiveanalytical instruments for the pharmaceutical, biological, environmentaland forensic markets.

Keeton Industries, Inc. www.keetonaqua.comFort CollinsKeeton Industries manufactures products for both the fisheries and aquacultureindustries. The company works with private companies and federal, state andlocal governmental agencies throughout the U.S. and overseas.

KEMS Biotest International www.kemsbiotest.comCentennialKEMS BioTest’s medical devices meet the needs of beef and diary producersby providing quick, actionable, on-site and cost-effective herd health testresults and information.

Kestrel Labs www.kestrellabs.comBoulderKestrel Labs finds innovative medical device concepts, conducts research todemonstrate the product viability and moves products rapidly throughdevelopment phases to early market introduction.

Labac Systems, Inc. www.labaconline.comDenverLabac Systems, Inc., designs and builds high quality, innovativequadriplegic seating systems.

Lane Manufacturing, Inc. www.lane-mfg.comDenverLane Manufacturing, Inc., produces gentle and cost effective large animalreproductive equipment and supplies.

Lexicor Research Center www.lexicor.comBoulderLexicor manufactures an EEG data acquisition medical device called theDigital Cortical Scan™. The Company also offers quantitative EEG dataanalysis through its DataLex™ Reporting Service.

Light Force Therapy, Inc. www.lightforcetherapy.comElizabethLight Force Therapy’s light emitting diodes produce a unique combinationof frequency and wavelength to elevate muscle tissue temperature andincrease circulation to relieve pain and relax muscles.

Little & CompanyGrand JunctionLittle and Company is a surgical and medical instrument manufacturer.

McKinley Medical LLLP www.mckinleymed.comWheatridgeMcKinley Medical offers infusion technology designed for high quality drugdelivery. McKinley Medical’s pain management systems lead in theorthopedics and general surgery markets.

Medical Modeling LLC www.medicalmodeling.comGoldenMedical Modeling produces highly accurate 3D physical models derived frommedical imaging modalities from CTs and MRIs.

Medical Simulation Corporation www.medsimulation.comDenverMedical Simulation’s products help healthcare professionals train in risk-free environments, improve patient outcomes and accelerate the deliveryof new devices and procedures to the marketplace.

Meritech, Inc. www.meritech.comEnglewoodMeritech, Inc., manufactures the CleanTech® automated hand washing andglove washing systems that remove harmful pathogens and contaminantsfrom bare as well as gloved hands.

Mesa Laboratories, Inc. www.mesalabs.comLakewoodMesa Laboratories, Inc., sells and manufactures electronic measurementinstruments used to solve product quality problems in industrial,pharmaceutical and medical applications.

Mesa Orthopedic, Inc.Grand JunctionMesa Orthopedic manufactures orthopedic appliances, prosthetics andsurgical instruments.

Microtech Medical Systems, Inc.AuroraMicrotech Medical Systems, Inc., produces in-vitro diagnostic, physicianand surgical equipment.

MIQS, Inc www.miqs.comBoulderMIQS, Inc., provides knowledge-based healthcare information technologysolutions that minimize medical practice costs and risk. The Company’ssolutions maximize patient health and well-being.

MSPIEnglewoodMSPI manufactures surgical and medical instruments and performs medicalresearch.

Navigant Biotechnologies™, Inc. www.navigantbiotech.comLakewoodWith the use of its Mirasol Pathogen Reduction Technology, NavigantBiotechnologies, Inc., offers organizations technology to improve bloodsupply safety. Its products apply light and riboflavin to inactivate bloodpathogen nucleic acids.

Optibrand Ltd. LLC www.optibrand.comFort CollinsOptibrand’s Secure Identity Preservation™ system offers food producers afraud-resistant, inexpensive system that positively identifies individualanimals from birth and throughout the food processing chain.

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Ortho SharpWestminsterOrtho Sharp manufactures dental equipment and supplies.

Otologics LLC www.otologics.comBoulderOtologics develops and manufactures the MET™ Ossicular Stimulator forsensorineural hearing loss treatment. This technology delivers a highfidelity signal directly to the middle ear.

Oval Window Audio www.ovalwindowaudio.comNederlandOval Window Audio produces induction loop assistive listening systems andunique visual and vibrotactile technologies that help deaf and hard ofhearing individuals to experience sound.

PARE Surgical, Inc. www.paresurgical.comEnglewoodPARE Surgical, Inc., is a leader in the development of innovativetechnologies for use in minimally invasive surgery.

Particle Measuring Systems www.pmeasuring.comBoulderParticle Measuring Systems sells its particle counting systems to life andphysical science markets. These precision instruments detect contaminantsin aerosols, liquids, gas streams and vacuum processing environments.

Peak Robots, Inc. www.peakrobotics.comColorado SpringsPeak Robotics is an engineering-rooted company that manufactures robots,special equipment, and turnkey automated systems for biotech, electronics,medical and semiconductor industries.

Pernicka Corporation www.pernicka.comFort CollinsPernicka Corporation develops and manufactures computer-controlledmachines that build ion lasers used for eye surgery and excimer lasers usedin heart surgery.

Physiodynamics, Inc. www.therastim.netEnglewoodTheraStim® is a unique, electrical neuromuscular stimulation modality. It isa distinctive breakthrough in the treatment of soft tissue rehabilitation.

Porta-Lung, Inc. www.porta-lung.comDenverPorta-Lung, Inc., manufactures noninvasive respiratory support devices.

Preferred Medical Products www.pmpcolorado.comEnglewoodPreferred Medical specializes in the manufacture of stainless steel medicalcomponents for hypodermic needles and lancet type products.

Probetronix www.probetronix.netColorado SpringsProbetronix is a premier manufacturer of oscilloscope probes.

Protogenic, Inc. www.protogenic.comWestminster Protogenic is a professional service bureau that manufactures prototypesand conceptual models using stereolithography rapid prototypingtechnology.

Protomed, Inc. www.protomed.netArvadaProtomed, Inc., uses the latest imagining software and laser driventechnology to create accurate anatomical models from CT scans.

Quest Product Development www.quest-corp.comEvergreenQuest Product Development provides full service engineering and productdevelopment services for the medical device industry.

Rand-Scot, Inc. www.rand-scot.comFort CollinsRand-Scot, Inc., manufactures products that helps people with serverphysical disabilities and is best know for its EasyPivot patient lift.

RJD Machining www.rjdmachining.comParkerRJD Machining provides quality components to medical equipment,aeorspace, electronic component, optical, measuring device, pumping andelectro-magnetic companies.

Rocky Mountain Orthodontics www.rmortho.comDenverRocky Mountain Orthodontics manufactures dental, physician and surgicalequipment.

Rocky Mountain Orthotics Labs www.rmolink.comDenverRocky Mountain Orthotics is the largest prescription orthotics manufacturerin the United States.

Sandhill Scientific, Inc. www.sandhillsci.comHighlands RanchSandhill Scientific, Inc., manufacturers medical instrumentation forgastroenterologists and endoscopic surgeons.

Shippert Medical Technologies Corporation www.shippertmedical.comEnglewoodShippert manufactures medical disposable products and instruments for theEar, Nose and Throat, Plastic Surgery, Emergency/Trauma Care, FamilyPractice, Pediatric, and Dermatology specialties.

Silverglide Surgical Technologies Inc. www.silverglidesurgical.comBoulderSilverglide Surgical Technologies, Inc., manufactures electrosurgicalinstruments enhanced with the SILVERGlide ® non-stick technology. Thistechnology prevents the sticking and buildup of tissue, which results infaster, more precise surgery.

Sonora Medical Systems www.4sonora.comLongmontSonora Medical Systems provides aftermarket products and services to thediagnostic ultrasound and MRI markets saving its customers millions ofdollars through its continuously expanding list of service offerings.

Sound Surgical Technologies LLC www.soundsurgical.comLafayetteSound Surgical Technologies is the world leader in innovative ultrasonictechnologies and related products for aesthetic surgery.

Starkey Laboratories, Inc. www.starkey.comColorado SpringsStarkey Laboratories, Inc., is the largest manufacturer of custom hearinginstruments in the world.

Steritool www.steritool.comGrand JunctionSteritool manufacturers stainless steel hand tools designed for use incritical production, sterile, clean room or corrosive environments.

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Summit Doppler Systems www.summitdoppler.comArvadaSummit Doppler Systems is a leading manufacturer of ultrasound Dopplersystems used to detect fetal heartbeat and to monitor peripheral arterialand venous blood flow.

Tartan Orthopedics, Ltd. www.tartanortho.comWestminsterTartan Orthopedics manufactures an entire line of orthopedic products.

Teledyne Water Pik www.waterpik.comFort Collins and LovelandSince Waterpik Technologies began in 1962, we’ve been a leadingdeveloper, manufacturer and marketer of revolutionary dental care,showerheads, massagers and water filtration products.

The Alpha Group & Associates www.alphagroup.usBroomfield The Alpha Group provides comprehensive radiation detectioninstrumentation, services and programs designed protect the worker, thegeneral public and the environment.

The Spectranetics Corporation www.spectranetics.comColorado SpringsSpectranetics develops, manufactures and markets to physicians andhospitals its “cool” ultraviolet excimer laser technology for treatingmultiple cardiovascular procedures.

Thermo Electron Corporation www.thermo.comBoulder Thermo Electron’s business unit, Point of Care and Rapid Diagnostics,makes a variety of patient tests for clinical use for everything fromstreptococcus and influenza to sexually transmitted diseases.

Titan Scan Systems www.titanscan.comAuroraTitan Scan Technologies uses linear accelerator technology, first developedby The Titan Corporation for national defense purposes in the mid-1980's,to manufacture electron beam system specifically for sterilization ofmedical devices in their final shipping containers.

TMJ Implants, Inc. www.tmj.comGoldenTMJ Implants, Inc., manufactures, markets and sales temporomandibularjoint disease products.

Transtracheal Systems, Inc. www.tto2.comEnglewoodTranstracheal Systems, Inc., manufactures SCOOP Transtracheal OxygenCatheters, Transtracheal Surgical Kits, Oxygen Tubing and Supplies.

TRS, Inc. www.oandp.comBoulderTRS, Inc., is leading innovator of body-powered prosthetic devices in theworld.

UTI-Star Guide USA www.utitec.comDenverUTI Corporation provides finished devices, assemblies and components tothe medical device OEM market.

Valleylab, Inc. www.valleylab.comBoulderValleylab, Inc., develops and manufactures advanced energy-based surgerysystems which includes electro-surgical generators and devices, vesselsealing systems, ultrasonic surgery systems and a complete line ofaccessories and disposables.

Wasson-Ece Instrumentation www.wasson-ece.comFort CollinsWasson-ECE Instrumentation specializes in configuring and modifying newor existing gas chromatographs to become guaranteed, turnkey analyticalsystems.

Wi, Inc. www.wi-llc.comEnglewoodWi, Inc., provides design and development services to the medical deviceindustry. The Company specializes in the engineering of electro-mechanicaland disposable medical products.

Wireless Medical, Inc. dasjes@msn.comAuroraWireless Medical, Inc., develops wireless, cell phone and internet basedtherapy guidance devices for congestive heart failure patients.

Ximedix , Inc. www.ximedix.comColorado SpringsXimedix, Inc., develops insulated pouches that maintain the temperatureof warm and cool solutions.

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ACCOUNTINGHein & Associates, CPAwww.heincpa.com

Pricewaterhouse Cooperswww.pwc.com

Ernst & Youngwww.ey.com

ARCHITECTSLS Planningwww.lsplanning.com

Maynard/David Partnership, Inc.www.maynarddavid.com

RNL Designwww.rnldesign.com

Abo Cervantes Loos Priebe Architecturewww.aclparchitecture.com

ATTORNEYSCooley Godward, LLPwww.cooley.com

Faegre & Benson, LLPwww.faegre.com

Fairfield and Woods, P.C.www.fwlaw.com

Hogan & Hartson, L.L.P.www.hhlaw.com

Holland & Hart LLPwww.hollandhart.com

Holme Roberts and Owenswww.hro.com

Marsh Fischmann & Breyfogle, LLPwww.mfblaw.com

Merchant & Gouldwww.merchant-gould.com

Patton Boggs, LLPwww.pattonboggs.com

Sheridan Ross PCwww.sheridanross.com

Townsend & Townsend and Crew LLPwww.townsend.com

ECONOMIC DEVELOPMENTAdams County Economic Development, Inc.www.adamscountyed.com

Arvada Economic Development Associationwww.aeda.biz

Aurora Economic Development Councilwww.auroraedc.com

British Consulate - Denverwww.BritainUSA.com

Canadian Consulatewww.dfait-maeci.gc.ca/can-am/menu-en.asp?mid=48

City of Denverwww.ci.denver.co.us

CO. Office of Economic Development & Int’l Tradewww.state.co.us/oed

Denver Metro Chamber/Metro DenverEconomic Development Councilwww.denverchamber.org

DIA Partnershipwww.diapartnership.org

Jefferson Economic Councilwww.jeffco.org

JETRO Denverwww.jetro.go.jp

Longmont Area Economic Councilwww.longmont.org

Northern Colorado Economic DevelopmentCorp.www.ncedc.com

Northern Ireland Technology and DevelopmentCentemcmahondenver@aol.com

EDUCATIONAims Community Collegewww.aims.edu

Community College of Aurorawww.ccaurora.edu

DeVry Universitywww.devryschools.com

Front Range Community Collegewww.frontrange.edu

FACILITIESAdvanced Lab Conceptswww.alc-corp.com

bioBubblewww.biobubble.com

Growth Management Consultingjredenba@ix.netcom.com

Haselden Construction, Inc.www.haselden.com

InterTech Planning and Designdgundersen@earthlink.net

ISEC Laboratory Serviceswww.iseinc.com

M.A. Mortenson Companywww.mortenson.com

Outsource Facility Solutionsmark@outsourcefs.com

Sherrill & Companywww.sherrillco.com

VECO USAwww.veco.com

FINANCIALBlankenship Financial Servicesb.blankenship@prodigy.net

Boulder Ventures Ltd.www.boulderventures.com

Cadwest Partnerswww.cadwestpartners.com

Capital Funding Strategieskdeines@CFS-LLC.com

Commerce Bankwww.commercebankcolorado.com

Merrill Lynchwww.ml.com

Morgenthaler Ventureswww.morgenthaler.com

Quasar Groupwww.quasargroup.com

Sequel Venture Partnerswww.sequelvc.com

Silicon Valley Bankwww.svb.com

Tangowww.tangogroup.com

UV Partnerswww.uven.com

W.G. Nielsen & Companywww.wgnielsen.com

Wells Fargowww.wellsfargo.com

HR PLACEMENT/SEARCHDHR Internationalwww.dhrintl.net

Employer Serviceswww.esgnet.com

Kelly Scientific Resourceswww.kellyservices.com

Kforce Scientificwww.kforce.com

On Assignment, Inc.www.labsupport.com

Volt Technicalwww.volt.com

Bioscience Resources

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INDUSTRYCONSULTANT/SPECIALIZEDSERVICESAffygility Solutionswww.affygility.com

All Language Alliancewww.languagealliance.com

Alphatek Inc.www.alphatek-inc.com

Biomed Inkwww.biomedink.com

CBR International Corp.www.cbrintl.com

Cericon, LLCwww.cericon.com

Chart Biotech Consultingchart1973@aol.com

Downs Marketingjdowns48@mac.com

Emerging Medical Technologiestcmemt@aol.com

Excel Biomedical Associatesjmaluta@aol.com

Knowledge-Forge Inc.www.knowledge-forge.com

M.W. Wenzel Consulting, Inc.http://home.earthlink.net/~mwenz/main.html

Marmaro Scientific Consultingwww.marmaroscientific.com

Medical Device Consultants, Inc.www.mdci.com

Reguluswww.netregulus.com

Onody Associateswww.onodyassoc.com

Paul L. Anderson Productionwww.paulanderson.com

Peak to Peak Pharmaceutical AssociatiesDavid.Denny@attbi.com

QuickSTATwww.qicstat.com

Reglera Corporationwww.reglera.com

Reimbursement Principles, Inc.www.reimbursementprinciples.com

Resnik Partnerswww.resnikpartners.com

Rose Biomedical Development Corporationwww.rosebiomed.com

Scientific Due Diligencecfferris@concentric.net

Strategy 3www.samsondesign.com

Summit Roundtablewww.summitroundtable.com

Tatum Partnerswww.tatumpartners.com

Taylor Medical Technology & Consultingwww.taylormedtech.com

VWR Internationalwww.vwr.com

INSURANCEChubb Group of Insurance Companieswww.chubb.com

Turnock Companieswww.turnockcompanies.com

Van Gilder Insurance Corporationwww.vgic.com

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RESEARCH/OFFICE PARKSFitzsimons Redevelopment Authority (FRA)ww.colobio.com

Forest City Enterprises, Inc.www.fceinc.com

Pratt Managementwww.prattprop.com

Westfield Development/Frederick Rosswww.frederickross.com

TECHNOLOGYIBM Life Scienceswww-1.ibm.com/industries/lifesciences

Strategic Computing, Inc.www.scicomputing.com

Veraxis, Inc.www.veraxisinc.com

Hewlett-Packardwww.hp.com

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OTHERPhRMAwww.phrma.org

PR/MARKETINGBoomcom Communicationswww.boomcom.com

Burns Marketing Communicationwww.burnsmarketing.com

GBSMwww.gbsm.com

Griff/SMC, Inc. Marketing Communicationswww.griffsmc.com

Image Is…Communications, Inc.www.imageis.com

Metzger Associateswww.metzger.com

Visual Science, Inc.www.visualsci.com

REAL ESTATEBitzer Real Estate Partnerswww.bitzerrep.com

Staubachwww.staubach.com

RESEARCHINSTITUTION/UNIVERSITYThe Children’s Hospital Research Institutewww.thechildrenshospital.org

Colorado State Universitywww.colostate.edu

Colorado State University Research Foundationwww.csurf.org

National Jewish Medical & Research Centerwww.njc.org

University of Coloradowww.cu.edu

University of Denverwww.du.edu

University of Northern Coloradowww.unco.edu

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