The

BIOCHEMICAL

JOURNAL

1 December 1979 Volume 183, No. 3

EDITORIAL BOARDChairmanJ. T. Dingle

Deputy ChairmenJ. A. LucyC. I. PogsonA. J. KennyJ. B. Clark

Editorial ManagerA. G. J. Evans

P. M. Bayley*J. W. BradbeerA. C. BrayJ. W. BridgesD. N. BrindleyH. G. BrittonK. BrocklehurstR. B. CainB. A. CookeA. J. Cornish-BowdenD. D. DaviesR. T. DeanR. M. DentonF. M. DickinsonG. J. DuttonP. C. EngelJ. E. FothergillJ. L. Gordon

D. E. GriffithsL. A. GrivellB. A. HaddockL. HueP. LundR. M. MarchbanksG. MurphyN. B. MyantK. B. M. ReidD. RobinsonD. SchulsterJ. E. ScottS. P. Spragg*D. R. StanworthM. J. A. TannerR. T. Walker*Nominated by the BritishBiophysical Society

Overseas Advisory Panel

H. Beinert (U.S.A.), H. F. DeLuca (U.S.A.), W. Fiers (Belgium), R. W. Hanson (U.S.A.),0. Hayaishi (Japan), B. Hess (Germany), D. B. Keech (Australia), T. C. Laurent (Sweden),L. F. Leloir (Argentina), R. Ross (U.S.A.), M. Schramm (Israel), A. Tissibres (Switzerland),D. Trentham (U.S.A.), A. D. Vinogradov (U.S.S.R.), 0. Wieland (Germany)

oc,LnEMdCo4 T B e a

4 -ts London: The Biochemical Society

THE BIOCHEMICAL SOCIETY

OFFICERS AND COMMITTEE, 1979-80

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ACKNOWLEDGEMENT TO REFEREES

The Editorial Board of the Biochemical Journal gratefully acknowledges the assistancegiven during the 1978-79 academic year by the following referees:

E. P. AbrahamP. S. AgutterS. AinsworthM. AkhtarS. Y. AliD. AllanA. AllenA. K. AllenJ. C. AllenR. P. AmblerJ. C. AndersonP. AndrewsD. J. AnsteeC. AnthonyJ. F. AntoniwH. R. V. ArnsteinP. AshbyS. J. H. AshcroftC. C. AshleyE. D. T. AtkinsG. L. AtkinsA. AtkinsonM. Atwood

H. S. BachelardJ. S. D. BaconA. A.-B. BadawyA. J. BaileyE. BaileyG. S. BaileyG. D. BairdC. W. BamforthA. D. BanghamB. E. C. BanksJ. BarberA. N. BarclayW. G. BardsleyT. BarkasM. J. BarnesA. J. BarrettJ. BarrettW. BartleyJ. M. BasfordM. BaylissG. BeddardT. J. C. BeebeeR. B. BeecheyJ. G. BeeleyE. A. BellD. S. BendallJ. P. BennettM. J. BerridgeC. S. Berry

B. BillingD. BillingtonG. D. BirnieJ. 0. BishopN. BlackburnJ. A. BlairC. C. F. BlakeR. BonnettR. BoothR. F. G. BoothN. M. Borthwick1. A. D. BouchierD. H. BoxerC. A. R. BoydG. S. BoydE. M. BradburyH. BraunsbergH. G. BrayI. BremnerK. BrocklehurstJ. R. BronkP. BrookesC. J. W. BrooksG. T. BrooksE. G. BrownS. B. BrownR. W. BrownseyK. R. BruckdorferD. BrundishC. J. BrutonJ. BryantC. F. A. BryceJ. D. Bu'lockB. BurchellK. BurdettR. H. BurdonR. BurgoyneD. C. BurkeK. BurtonA. F. BuryP. H. W. ButterworthP. J. ButterworthP. J. Buttery

R. CammackA. M. CampbellM. CampbellD. J. CandyM. CannonB. CaponE. M. CareyC. J. CarterT. Cawston

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M. A. CawthorneE. M. ChanceD. ChapmanJ. B. ChappellR. CharlesP. A. CharlwoodJ. ChayenC. J. ChestertonW. W. ChristieJ. B. CleggM. J. ClemensG. M. CloreS. CockcroftA. J. CofferJ. R. CogginsG. M. CohenP. CohenR. ColemanJ. ConchieG. M. W. CookB. A. CookeH. G. CooreJ. G. CooteD. B. CoultD. CoxR. A. CoxM. J. C. CrabbeB. CrabtreeR. K. CraigM. A. CrawfordN. CrawfordJ. M. CreethG. W. CrosbieM. J. CrumptonA. CryerE. CundliffeV. J. CunninghamL. Cuzner

K. DalzielN. E. DanceP. D'Arcy HartD. R. DaviesP. DaviesR. C. DaviesA. N. DavisonE. A. DawesA. P. DawsonR. M. C. DawsonR. T. DeanH. T. DelvesF. De MatteisJ. J. M. de Vilder

ACKNOWLEDGEMENT TO REFEREES

A. J. DicksonI. DicksonR. DilsH. B. F. DixonK. S. DodgsonA. S. R. DonaldI. A. DonaldsonS. DoonanV. C. DuanceR. J. S. DuncanJ. P. Durham

J. S. EasterbyJ. E. EastoeA. A. EddyJ. EdwardsP. A. EdwardsR. A. EisenthalG. H. ElderD. J. EllarK. R. F. ElliottP. J. EnglandM. B. EnserM. P. EsnoufM. C. W. EvansS. EvansW. H. Evans

R. B. FearsJ. FeeneyA. FeinsteinH. FellS. FergusonE. B. FernH. N. FernleyJ. B. C. FindlayJ. B. FineanR. J. FlowerB. FolkesP. J. FordJ. E. FothergillD. R. FraserK. N. FraynN. FrearsonR. B. FreedmanD. J. Fry

M. K. GaitondeJ. T. GallagherT. GalliardS. D. GangolliP. J. GarlickC. GarnerR. A. GarrettG. A. GartonP. J. GearyG. F. GibbonsD. Gibbs

I. GilesR. S. GilmourB. L. GinsborgM. GinsburgA. GlauertH. GlossmannJ. GloverP. G. GlynnL. J. GoadJ. P. GoddardD. F. GoldspinkB. D. GompertsG. GoodayG. H. GoodwinA. H. GordonG. GouldR. 0. GouldD. B. GowerA. B. GrahamJ. M. GrahamD. A. W. GrantM. E. GrantA. R. GreenB. GreenC. GreenC. D. GreenN. M. GreenR. GreenC. GreenwoodG. GregoriadisN. A. GregsonJ. R. GriffithsK. GriffithsM. GronowF. D. GunstoneM. I. GurrH. GutfreundS. GutteridgeW. E. Gutteridge

B. A. HaddockC. N. HalesA. P. HalestrapS. E. HalfordL. HallI. W. HalliburtonT. HallinanB. HalliwellW. A. HamiltonJ. B. HarborneJ. J. HardingT. E. HardinghamK. G. HardyR. A. HarknessE. J. HarrisP. HarrisonR. HarrisonR. A. P. Harrison

I. C. HartJ. HarwoodH. HassallJ. N. HawthorneJ. HaywoodM. J. R. HealyD. F. HeathM. F. HeathF. W. HemmingD. HemsP. J. F. HendersonR. HendersonB. N. HerbertG. M. HerringH.-G. HersT. R. HeskethA. J. HigginsS. J. HigginsR. H. HintonA. R. HipkissP. C. HiromC. H. S. HitchcockM. W. HoR. HoffenbergJ. S. HoldenG. HoldsworthM. R. HollawayA. A. HortonL. HoughM. D. HouslayS. L. HowellA. K. HugginsN. C. Hughes-JonesT. HuntI. S. HunterW. M. Hunter

R. IlesH. P. A. IllingW. J. IngledewR. F. IrvineR. F. ItzhakiL. L. Iversen

G. JackA. H. JacksonD. S. JacksonI. J. JacksonJ. B. JacksonR. J. JacksonW. JacobsonA. T. JamesJ. JanneR. JeffcoatJ. JefferyD. H. JenkinsonH. A. JohnR. A. John

IV

ACKNOWLEDGEMENT TO REFEREES

E. W. JohnsL. JohnsonA. P. JohnstoneC. T. JonesC. W. JonesD. S. JonesD. W. JonesE. A. JonesK. M. JonesM. N. Jones0. T. G. JonesR. H. JonesM. C. Jones-MortimerJ. D. Judah

J. KayJ. E. KayH. M. KeirR. G. 0. KekwickJ. KelleherG. L. KellettD. P. KellyP. W. KentM. A. KerrB. KettererD. C. KilpatrickR. J. B. KingC. J. KirkD. N. KirkG. G. B. KlausK. KleppeJ. KlootwijkG. KnightJ. T. KnowlerP. F. KnowlesH. A. KrebsA. Kurtz

C. LambJ. M. LandA. LangP. J. LargeG. H. LatheD. E. M. LawsonP. J. LeaD. H. LeabackD. P. LeaderA. G. LeeR. M. LeechL. LimJ. LittletonD. LloydJ. B. LloydU. E. LoeningA. K. LoughA. G. LoweD. J. LoweJ. S. Lowe

P. N. LoweJ. LumsdenG. LuntJ. P. Luzio

I. A. MacdonaldA. J. MacGillivrayI. MaclntyreW. H. MagerL. MagosW. I. P. MainwaringA. D. B. MalcolmJ. MandelstamT. J. MantleA. MaroudasR. D. MarshallB. R. MartinS. R. MartinR. M. MasonA. P. MathiasE. K. MatthewsH. R. MatthewsR. J. MauerE. B. MawerP. A. MayesI. McConnellF. McCormickC. A. McDevittR. G. McDonald-GibsonJ. O'D. McGeeJ. D. McGivanR. A. J. McllhinneyH. McIlwainN. McIntyreA. E. McLeanA. G. McLennanC. McMartinM. MeikleM. A. L. MelvinW. T. MelvinS. MenashiT. B. MephamD. MercerN. MianR. H. MichellB. MiddletonM. MidgleyB. J. MiflinP. MillburnG. L. MillsD. J. MillwardE. J. Milner-WhiteM. MitchellA. J. G. MoirD. L. MollinW. MontagueT. A. MooreD. Morton

V. MosesG. P. MossJ. MowbrayJ. MoyleK. A. MundayG. MurphyK. MurrayJ. Myddleton

W. G. NaylerE. A. NewsholmeE. NiceD. G. NichollsB. W. NicholsH. G. NimmoI. A. NimmoA. R. NobleA. C. T. NorthD. H. NorthcoteJ. K. NorymberskiP. B. Nunn

M. J. O'HareS. C. OliverM. G. OrdJ. L. H. O'RiordanB. A. OrsiJ. H. Ottaway

M. I. PageR. H. PainV. M. PainA. J. PaineJ. H. ParishD. V. ParkeD. S. ParkerR. M. E. ParkhouseD. S. ParsonsC. A. PasternakA. J. PatelJ. V. F. PatersonD. PeacockW. S. PeartJ. L. PeelA. E. PeggI. W. Percy-RobbS. V. PerryG. W. PettigrewC. F. PhelpsJ. H. PhillipsR. Pitt-RiversJ. D. PittsR. J. PollittJ. F. PowellK. PowellR. PowlsN. C. Price

v

ACKNOWLEDGEMENT TO REFEREES

R. G. PriceI. Pull

J. R. QuayleR. V. Quincey

G. K. RaddaC. I. RaganW. N. M. RamsayD. B. RamsdenP. J. RandleH. A. RaueT. ReesM. RennieJ. J. ReynoldsE. G. RichardsD. RidgeG. C. K. RobertsC. RobinsonD. S. RobinsonG. B. RobinsonR. RodnightD. B. RoodynF. A. RoseB. D. RossC. E. RoweP. RowellE. V. RowsellM. G. RumsbyR. G. G. RussellB. E. Ryman

E. D. SaggersonG. SainsburyJ. SaklatvalaJ. A. SalmonP. G. SammesJ. G. SchofieldW. SchwartzT. A. ScottM. C. ScruttonA. W. SegalK. SelbyM. SelwynS. ShallA. M. SheltawyH. S. A. SherrattP. SheterlineP. R. ShewryC. A. ShuttleworthJ. L. SimkinH. SipsT. SlaterB. SmithJ. D. SmithK. E. Smith

L. L. SmithR. L. SmithS. A. SmithK. SnellE. SpanosB. SpeakeR. N. SpeakeN. SpencerJ. C. StanleyD. A. StansfieldP. StarkeyF. S. StevenL. StevensJ. L. StirlingL. A. StockenD. StriblingM. StubbsK. E. SucklingP. H. SugdenM. SummersI. W. SutherlandP. F. SwannS. SwillensB. SykesA. M. Symons

G. H.TaitJ. R. TataC. TaylorF. W. J. TealeD. L. ThatcherG. H. ThomasP. ThomasC. J. ThompsonR. J. ThompsonA. ThomsonR. Y. ThomsonK. J. 1. ThorneR. N. F. ThorneleyC. J. ThurstonK. TiptonG. M. TongeA. Travers1. P. TrayerA. TreffryA. R. TrimP. W. TrudgillP. K. TubbsA. J. TurnerG. TurnockD. D. Tyler

P. N. T. UnwinM. F. Utter

L. R. G. ValadonG. van de Werve

H. van KeulenS. VaughanR. Virden

H. WaldmannS. G. WaleyC. H. WalkerD. A. WalkerD. G. WalkerP. G. WalkerP. L. WaltonG. WardJ. C. WaterlowW. M. WatkinsM. WebbJ. B. WeissP. D. J. WeitzmanI. C. WestC. W. WhartonF. R. WhatleyK. P. WheelerA. M. WhiteD. A. WhiteG. F. WhiteI. N. H. WhiteP. R. WilkesJ. M. WilkinsonS. G. WilkinsonA. WilliamsA. F. WilliamsD. J. WilliamsJ. WilliamsK. E. WilliamsH. G. Williams-AshmanA. R. WilliamsonD. H. WilliamsonR. WilliamsonE. D. WillsM. T. WilsonN. H. WilsonB. G. WinchesterG. P. WinterP. J. WinterburnG. J. WishartM. H. WisherJ. F. WoodleyD. E. WoolleyM. WorwoodJ. M. WrigglesworthF. S. WustemanC. H. Wynn

D. W. YatesD. W. YoungJ. D. YoungJ. L. Young

Vi

CONTENTS

INDEX OF AUTHORS

Anderson, I. G.

Barber, D.Betts, G. F.Biswas, R.Booth, N. A.Bostian, K. A.Bowman, C. M.Bradbury, E. M.Briggs, T.Brunori, M.

Campbell, R. D.Carlstedt, I.

Carter, R. J.Cary, P. D.Cawston, T. E.Childs, R. A.Christeller, J. T.Clarke, F. M.Colosimo, A.Coster, L.

Dawson, R. M. C.Dorn, C. P.Drabble, W. T.Dyer, T. A.

Farooqui, A. A.Feizi, T.Fothergill, J. E.

Ganguly, J.Garland, P. B.Gilbert, H. J.Goodwin, G. H.

PAGE507

701633737

573, 579633

595, 605657507701

573, 579669589657647755747663701669

691555481

595, 605

531755

573, 579

501561481657

Green, F. J.Greenwood, C.

Harris, J. U.Hartman, P. G.Haslewood, G. A. D.Hazlewood, G. P.Heinegard, D.Hiskey, R. G.Hunt, D. M.

Johns, E. W.Johnson, A. J.

Kemp, P.Kerr, M. A.Kitson, T. M.Klein, R. A.Koehler, K. A.Koga, M.

Laing, W. A.Lewis, R. A.Linker, A.Lowe, C. R.

Majumder, G. C.Malmstrom, A.Marsh, H. C.Merskey, C.Moore, C. H.Morton, D. J.

Newman, G. E.Nicholls, P.Nicotra, F.

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623657507691539513721

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691615751691513683

747547711481

737669513623561663

731519495

Ohtake, H.Olayemi, J. Y.Oldham, R. S.

Padmanaban, G.Paulsson, M.Phizackerley, P. J. R.Pierzchala, P. A.Poole, P. L.Port, A. E.Prasad, V. R.

Rao, M. R. S.Robinson, D.Ronchetti, F.Russo, G.

Scharen, H.Scott, M. E.Shooter, K. V.Silvestrini, M. C.Smith, M. A.Snyder, F. F.Springham, M. G.Srivastava, P. N.Stewart, M.

Tokes, L.Toma, L.Town, M.-H.Tyler, J. A.

Walsh, T. A.Wang, M.-T.

Zimmerman, M.

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PHOTOCOPYING

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INDEX OF AUTHORS

Index of Authors

Adams, M. W. W.Akhtar, M.Allen, A. K.Anderson, I. G.Anstee, D. J.Armstrong, F. A.Aronsson, A.-C.Azanza, J.-L.

Bachhawat, B. K.Bannister, J. V.Bannister, W. H.Barber, D.Bartold, P. M.Beebee, T. J. C.Bellini, T.Benfield, P. A.Bennick, A.Bernstein, S. L.Betts, G. F.Biswas, R.Booth, N. A.Borensztajn, J.Bostian, K. A.Bowman, C. M.Bradbury, E. M.Brady, R. 0.Bratcher, S. C.Briggs, T.Brocklehurst, K.

Butler, J.Brooks, R. R.Brunori, M.Butterworth, P. J.

Campbell, R. D.Cannon, M.Cantoni, L.Carlstedt, I.Carter, R. J.Cary, P. D.Casale, G. P.Cass, A. E. G.Cawston, T. E.Chan, P.-K.Chance, B.Charteris, A. T.Childs, R. A.Chipko, B. R.Coombs, T. L.Christeller, J. T.Clarke, F. M.Colosimo, A.Corbett, M. D.Coster, L.Cottin, P.

Dallocchio, F.Daniel, E.

Vol. 183

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175-178133-137507-511193-203471-474

23-30339-347

185-188127-132127-132701-709467-470

43-54297-302429 444115-126181-184633-646737-743

573-578, 579-588171-174633-646

595-604, 605-613657-662205-212255-268507-511

223-231, 233-238369-373471-474

65-71701-709

239-245, 247-254

573-578, 579-588115-12699-103669-681589-594657-662105-114127-132647-656147-156375-379361-368755-758269-276277-283747-750663-667701-709269-276669-681339-347

297-302325-330

PAGEDawson, R. M. C. 691-700de Fonseka, K. 375-379De Matteis, F. 99-103Dobson, N. 395-403Dorn, C. P. 555-559Drabble, W. T. 481-494DuBien, L. H. 83-90Ducastaing, A. 339-347Duncan, R. J. S. 459-462Dyer, T. A. 595-604, 605-613

Elmore, D. T. 389-394

Ferri, A. 475-476Fagg, G. E. 159-162Farooqui, A. A. 531-537Feizi, T. 755-758Felix, R. 73-81Fleisch, H. 73-81Forcina, B. G. 429 444Fothergill, J. E. 573-578

579-588Franceschi, C. 381-388Francis, J. E. 455-458

Ganuly, J. 501-506Garland, P. B. 561-572Gaylor, J. L. 405-415Getz, G. S. 83-90Ghosh, M. 185-188Gibbons, G. F. 309-315Gibbons, I. 429 444Gilbert, H. J. 481-494Gillespie, D. A. F. 477-480Gioio, A. E. 181-184Goodwin, G. H. 657-662Gore, M. G. 175-178Grand, R. J. A. 285-295Grasso, J. A. 105-114Grayson, J. E. 239-245

247-254Grazi, E. 475-476Green, F. J. 547-553Greenwood, C. 701-709

Hall, D. 0. 11-22Hardman, N. 477-480Harris, J. U. 623-632Hartley, B. S. 31-42Hartman, P. G. 657-662Hasemann, V. 127-132Haslewood, G. A. D. 507-511Hazlewood, G. P. 691-700Heimer, Y. M. 179-180Heinegard, D. 539-545Henderson, R. A. 471-474Herbert, J. A. L. 369-373Hill, H. A. 0. 127-132Hiskey, R. G. 513-517Hunt, D. M. 721-730

Ilan, E.Irvine, G. B.

Johansen, J. T.John, R. A.Johns, E. W.Johnson, A. J.Jones, D. P.

Kaplan, B. B.Kellett, G. L.Kemp, P.Kerr, M. A.Kitson, T. M.Kivirikko, K. I.Klein, R. A.Koehler, K. A.Koga, M.Kotlar, T. J.Kronman, M. J.Kyle, D.

Laing, W. A.Lewis, R. A.Liew, C.-C.Lindahl, R.Linker, A.Lowe, C. R.Lusk, L. T.

Madapallimattam, G.Magri, E.Majamaa, K.Majumder, G. C.Malmstrom, A.Malthouse, J. P. G.

Mannervik, B.Marmstal, E.Marsh, H. C.Mawby, W. J.McIntyre, L. J.

Melcher, U.Merskey, C.Minelli, A.Mitropoulos, K. A.Moore, C. H.Morton, D. J.Moss, D. W.Mukkur, T. K. S.Mullen, E.

Neuberger, M. S.Newman, G. E.Nicholls, P.Nicotra, F.Nitta, K.Norris, R.

PAGE325-330389-394

127-132361-368657-662623-632405-415

181-184349-360691-700615-622751-753303-307691-700513-517683-690171-174255-268417-427

747-750547-553147-15655-64

711-720481-494

83-90

115-126475-476303-307737-743669-681223-231233-238

23-3023-30

513-517193-203205-212213-221395-403623-632361-368309-315561-572663-667189-192463-465175-178

31-42731-736519-529495-499255-268369-373

759

INDEX OF AUTHORS

Ogston, A. G.Ohtake, H.Olayemi, J. Y.Oldham, R. S.Ostrow, J. D.Overnell, J.

Padmanaban, G.Pasnak, C. F.Patterson, R. A.Paulsson, M.Perham, R. N.Perry, S. V.Phizacherley, P. J. R.Pierzchala, P. A.Poole, P. L.Port, A. E.Prasad, V. R.Preston, B. N.Pullinger, C. R.

Quarles, R. H.

Rao, M. R. S.Raymond, J.Riklis, E.Rippa, M.Risteli, J.Roberts, D.

PAGE1-9

683-690657-662507-511139-146277-283

501-506213-221

31-42539-545429 444285-295731-736555_559

Robin, J.-M.Robinson, D.Ronchetti, F.Russo, G.

Schren, H.Scott, J. E.Scott, M. E.Serafini-Cessi, F.Shipton, M.Shooter, K. V.Signorini, M.Silvestrini, M. C.Smith, A. G.

633-646 Smith, M. A.721-730 Snyder, F. F.501-506 Somero, G. N.

1-9 Sperti, S.309-315 Springham, M. G.

Srivastava, P. N.2522

Stewart, M.205-212 Stoll, M. S.213-221 Stuchbury, T.

Sundaram, P. V.501-506 Surolia, A.339-347 Suschitzky, H.179-180 Sykes, A. G.297-302303-307349-360

Takagi, M.Tanaka, Y.

PAGE339-347623-632495-499495-499

507-51191-97

513-517381-388223-231657-662297-302701-709455-458463-465573-578589-594317-323381-388633-646531-537663-667139-146233-238445-451185-188369-373471-474

163-165163-165

Tanner, M. J. A.

Thonard, J. C.Tokes, L.Toma, L.Town, M.-H.Tryggvason, K.Tyler, J. A.

Vaheri, A.Van Overmeeren, E.Visser, T. J.Voltattorni, C. B.Vuento, M.

Waehneldt, T. V.Walker, L. F.Walsh, T. A.Wand, M.-T.Whitaker, K. B.Wiebkin, 0. W.Williams, D. G.

Yancey, P. H.Yon, R. J.

Zarembo, J. E.Zenone, E. A.Zimmerman, M.

PAGE193-203417-427467-470507-511495-499731-736303-307647-656

331-337167-169167-169361-368331-337

159-16283-90

701-709623-632189-192467-470417-427

317-323239-245247-254

139-146139-146555-559

1979

760

INDEX OF SUBJECTS

Index of Subjects

2-Acetamidofluorenehepatoma induction 55-64

2-Acetylaminofluorene, see 2-AcetamidofluoreneN-Acetylglucosamine

heparan sulphate oligosaccharides 711-720lectin inhibition 133-137

N-Acetylglucosaminidaseheparan sulphate oligosaccharides 711-720

Acid proteinasesoperational molarity 389-394

Actin (G-)protamine-induced ATPase 475-476

Actinidia chinensis (Chinese gooseberry, kiwifruit)actinidin (thiol proteinase) 233-238

Actinidinactive centre 233-238

Adenosine 5'-monophosphatesynthesis of derivatives for affinity chromatography481-494

Adenosine triphosphatecell-surface 737-743ecto 737-743epididymal spermatozoa 737-743Mg2"-dependent 737-743protamine and ATP-G-actin 475-476

Adenosine triphosphate analoguephosphofructokinase binding and inhibition 349-

360Adenylate cyclase

guanine nucleotide activation and stabilization 589-594

rabbit heart 589-594Agglutinins

myelin glycoproteins binding 213-221Albumin

serum, bovine see Bovine serum albuminAldehyde dehydrogenase

active-site thiol group 459-462cation-induced conformation changes 633-6462,2'-dithiodipyridine and disulfiram 751-753esterase activity 459-462K+ activation and stabilization 633-646liver and hepatoma 55-64subcellular distribution 55-64yeast 633-646

Aldehyde reagentsamino sugar 91-97DNA assay 91-97

Aldolase, see Fructose 1,6-bisphosphate aldolaseAlkaline phosphatasebone cells 73-81diphosphonates 73-81human placenta and kidney 189-192

Allyl-containing drugscytochrome P-450 modification 99-103

2-Allyl-2-isopropylacetamidecytochrome P-450 modification 99-103

5-Allyl-5-(1-methylbutyl)barbituratecytochrome P-450 modification 99-103

Vol. 183

Amino acid compositionD-arabitol dehydrogenase 31-42bovine complement component C4a 573-578bovine complement subcomponent Cls 579-588calmodulin-binding protein 285-295glyoxalase 1 23-30phosphoprotein B2 147-156plaice metallothionein 277-283tadpole-shrimp (Lepidulrius) haemoglobin 325-330vegetable-marrow lectin 133-1 37zinc-binding protein 683-690complement components C2, C2a and C2b 615-622copper-binding proteins 721-730hydrophobic proteins of lamellated bodies 731-736

Amino acid sequencesalivary acidic proline-rich protein A 1 15-126N-terminus of complement component C2 615-622N-terminus of complement component C4a 573-

578N-terminus of complement Factor B 615-622

Amino acid sequencesactive-site lysine of aldolase 429-444

2-Amino sugarsfluorimetric assay 91-97

2-Amino-2-deoxyhexosesfluorimetric assay 91-97

4-(N-Aminoethyl 2'-pyridyl disulphide)-7-nitrobenzo-2-oxa- 1 ,3-diazole

reaction with papain active centre 223-2314-(N-Aminoethyl 4-pyridyl disulphide)-7-nitrobenzo-2-

oxa-1 ,3-diazolesynthesis and reaction with papain 369-373

2-Amino-2-hydroxymethylpropane-1,3-diol, see Tris7-Amino-4-methylcoumarin derivatives

plasmin assay substrates 555-559Amphibians

bile-salt changes during metamorphosis 507-511AntigenFR, see FR antigen

Apolipoproteinschylomicrons 171-174lipoprotein lipase inhibition 171-174

Apoproteinshigh- and low-density lipoproteins 83-90

D-Arabitol dehydrogenaseKlebsiella aerogenes 31-42

Arginineaffinity chromatography of fibronectin 331-337

Aspartatebinding to aspartate transcarbamoylase 247-254

Aspartate transcarbamoylasecold-lability 239-245kinetics and stereochemistry ofaspartate binding 247-

254purification 239-245wheat-germ 239-245, 247-254

Azidecytochrome oxidase inhibition 519-529

Bacteriophage Q,BRNA polymerase 65-71

761

INDEX OF SUBJECTS

BacteriorhodopsinHalobacterium halobium purple membranes 175-178retinyl-binding site 175-178

Beanbroad, see Broad beancastor, see Castor beandwarf, see Dwarf beankidney, red, see Red kidney beansoya, see Soya bean

Bile saltschanges during amphibian metamorphosis 507-511

Bilirubinphotoisomerization 139-146phototherapy of neonatal jaundice 139-146

Blood groupssialoglycoproteins 193-203

Bone cellsalkaline phosphatase 73-81

Bovine serum albuminphosphorescence and fluorescence with dyes 561-572

Braincalmodulin-binding proteins 285-295isolation ofRNA 181-184myelin basic proteins 159-162

Broad bean (Viciafaba)chloroplast 5S rRNA sequences 595-6044.5S rRNA from chloroplasts 605-613

Butyrivibrio spp.long-chain dicarboxylic acids in lipids 691-700

Cadmiumbinding protein in plaice liver 277-283metallothionein induction in plaice liver 277-283

Cadmium-binding proteinisolation from plaice liver 277-283

Calcium ionsbinding to salivary proteins 115-126prothrombin conformations 513-517

Calmodulinbrain and other tissues 285-295

Calmodulin-binding proteininteraction with calmodulin and troponin C 285-295possible identity with myelin basic protein 285-295purification from brain 285-295

Candida utilisglucose 6-phosphate dehydrogenase 297-302

Carbohydrate compositionbovine complement subcomponent Cls 579-588

Carbohydrate-binding proteinsmuscle 755-758

Carbon monoxidecomplex with cytochrome c oxidase 519-529reaction with cytochrome oxidase 375-379

Carbonmonoxi-cytochrome oxidaselow-temperature spectroscopy 375-379

N-(3-Carboxypropionyl)aminodecyl-Sepharosepurification of aspartate transcarbamoylase 239-245

Carcinogenliver aldehyde dehydrogenase 55-64

Cartilageproteoglycans and matrix proteins 539-545

Cartilage matrix proteinsinteraction with proteoglycans 539-545purification and properties 539-545

Castor bean (Ricinus communis)lectin assay 185-188

Cathepsin Dinhibition and molarity determination 389-394

Central nervous systemmyelin lectin-binding glycoproteins 205-212, 213-

221Chick embryo

prolyl 3-hydroxylase 303-307Chinese gooseberry, see Actinidia chinensisChitin oligosaccharides

lectin inhibition 133-1374-Chloro-7-nitrobenzofurazanRNA polymerase inhibition 255-268

4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole, see 4-Chloro-7-nitrobenzofurazan

Chloroperoxidaseindole oxidation 269-276

Chloroplasts4.5S RNA from ribosomes 605-6135S rRNA sequences 595-604

Cholesterolregulation of synthesis 309-315

Chondroitin sulphatefibroblast proteoglycans 669-681

Chromatinhen oviduct retinol-binding proteins 501-506non-histone proteins 147-156phosphoprotein (B2) 147-156protein HMG 1 and histone HI 657-662

Chromatin subunitsphosphoprotein B2 147-156

Chylomicronsapoproteins and lipoproteins lipase 171-174

Chymosininhibition 389-394

Clostridium pasteurianumferredoxin 471-474

Cobalt ionsincorporation into porphyrins 99-103

Collagencollagenase digestion 647-656prolyl 3-hydroxylase 303-307

Collagenaselatency 647-656purification from pig synovium 647-656

Complementcomponent Cls 615-622component C2 and Factor B 615-622component C4a 573-578subcomponent Cls 579-588

Component C2purification and proteolysis 615-622

Component C4aamino acid composition 573-578isolation from bovine complement 573-578N-terminal sequence 573-578

'Compound C'cytochrome oxidase reaction 519-529

Concanavalin Amyelin glycoproteins binding 205-212, 213-221

Concanavalin A receptorsmyelin 205-212, 213-221

1979

762

INDEX OF SUBJECTS

Coppercytochrome c oxidase 519-529tissue contents in mice 721-730

Copper-binding proteinsamino acid compositions 721-730liver and kidney 721-730normal and mutant mice 721-730

Crustaceahaemoglobin 325-330

Cucurbita pepo, see Vegetable marrowCuimulus oophorus

dispersal by hyaluronidase 531-537Cyanidecytochrome oxidase inhibition 519-529

Cysteinezinc-binding protein 683-690

Cysteine residuepapain active centre 223-231, 369-373

Cysteine residuesplaice metallothionein 277-283

Cytochrome aa3cytochrome c oxidase 519-529

Cytochrome c oxidasecarbon monoxide complex 519-529reaction with carbon monoxide 375-379see also Pseudomonas cytochrome oxidase

Cytochrome P-450cholesterol biosynthesis 309-315porphyrin nucleus 99-103

Cytosolhen oviduct retinol-binding proteins 501-506

Cytosolic proteinstimulation of stearoyl-CoA desaturase 405-415

5'-Deiodinase, see lodothyronine 5'-deiodinaseDemethylation

lanosterol 309-315Deoxyguanosine kinase

inhibitors, substrates and effectors 547-553partial purification from pig skin 547-553

Deoxyguanosine 5'-monophosphatedeoxyguanosine kinase 547-553

Deoxyguanosine 5'-triphosphatedeoxyguanosine kinase 547-553

Deoxyribonucleic acidmechanism of assay methods 91-97Physarum polycephalum nuclei 477-480

Dermatan sulphatefibroblast proteoglycans 669-681

Dextranosmotic compression 1-9viscometry 1-9

Diabolic acids, see vic-Dimethylalkanedioic acidsNN'-Diacetylchitobiose

lectin inhibition 133-1373,5-Diaminobenzoic acid

fluorimetric assay reagent 91-97N-Diazoacetyl-L-phenylalanine 3-phenyl[2,3-3H]propyl-

amideproteinase inhibition 389-395synthesis 389-394

Dicarboxylic acidslipids of Butyrivibrio spp. 691-700long-chain, with vicinal dimethyl branching 691-700

Vol. 183

Dichloromethanediphosphonatealkaline phosphatase 73-81

3,4-Dihydroxyphenylalanine (dopa)reaction with dopa decarboxylase 361-368

3,4-Dihydroxyphenylalanine (dopa) decarboxylasedecarboxylation and transamination reactions 361-

368pyridoxal phosphate cofactor 361-368reaction with 3,4-dihydroxyphenylalanine 361-368

vic-Dimethylalkanedioic acidsButyrivibrio lipids 691-700

Diphosphonatesalkaline phosphate 73-81

2,2'-Dipyridyl disulphideneutral and cationic forms 233-238reaction with enzyme active centres 233-238reaction with papain active centre 223-231reaction with thiolate anions 233-238

Disseminated intravascular coagulationFR antigen 623-632

Disulfiram (tetraethylthiuram disulphide)aldehyde dehydrogenase 55-64, 751-753

2,2'-Dithiobis-(5-nitropyridine)aldehyde dehydrogenase 751-753

2,2'-Dithiopyridinealdehyde dehydrogenase activation 751-753

Dopa, see 3,4-DihydroxyphenylalanineDuckweed (Lemna minor)

chloroplast 5S rRNA sequences 595-6044.5 S rRNA from chloroplasts 605-613

Dwarf bean (Phaseolus vulgaris)chloroplast 5 S rRNA sequences 595-6044.5 S rRNA from chloroplasts 605-613

Dyesphosphorescence and fluorescence with proteins 561-

572

Elasmobranch fishesosmoregulation and protein structure 317-323

Enzymesbinding to muscle 663-667immobilization on nylon imidate 445-451

Eosinphosphorescence and fluorescence with proteins 561-

572Epididymis

spermatozoal ATPase 737-743Erythrocruorin

tadpole shrimp (Lepidurus) 325-330Erythrocyte membraneabnormal blood-group-active sialoglycoproteins 193-

203anion-transport protein 417-427

ErythrocytesMiltenberger, human 193-203

Erythropoietic cellsglobin mRNA 105-114

Erythrosinphosphorescence and fluorescence with proteins 561-

572Escherichia coliIMP dehydrogenase 481 494

Escherichia coli membranehydrogenase 11-22

763

INDEX OF SUBJECTS

Esterasealdehyde dehydrogenase 459-462

1,N6-Ethenoadenosine triphosphatephosphofructokinase binding and inhibition 349-360

Evolutionaldolases 429444

Factor Bpurification and proteolysis 615-622

FerredoxinClostridiumpasteurianum 471-474half-reduced eight-iron species 471-474

Fibrinogenthrombin and plasmin 623-632

Fibrinogen-fibrin-related antigen, see FR antigenFibroblasts

proteoglycans 669-681Fibronectinhuman plasma 331-337purification by affinity chromatography 331-337

Ficaprenol- Icis-trans alignment of isoprene units 163-16513C nuclear magnetic resonance 163-165

Ficus elastica (rubber plant)ficaprenol-1 1 163-165

Fisheselasmobranch, see Elasmobranch fishes

Fluorescein dyesphosphorescence and fluorescence with proteins 561-

572Fluorescence

phosphofructokinase and ATP analogues 349-360protein-bound dyes 561-572

Formatecytochrome oxidase inhibition 519-529

FR antigendisseminated intravascular coagulation 623-632purification by immuno-affinity chromatography 623-632

N-terminal analysis and proteolysis 623-632Frogs

bile-salt changes during metamorphosis 507-511Fructose 1,6-bisphosphate aldolase

binding to muscle 663-667Fructose 1,6-bisphosphate aldolases

active-site amino acid sequences 429-444evolution 429-444muscle and liver 429-444

Galactosaminoglycansfibroblast proteoglycans 669-681

,8-Galactoside-binding lectinsprimate and bovine muscle 755-758

Galactosyl-lysozymeuse in lectin assay 185-188

Gelatinfibronectin binding 331-337

Gingivaepithelial proteoglycans 467-470

Globinmessenger RNA 105-114

Globulin'cold-insoluble', see Fibronectin

Glucose 6-phosphate dehydrogenaseCandida utilis 297-302NADP+-binding site 297-302

/l-D-Glucuronidaseheparan sulphate oligosaccharides 711-720

Glutamate dehydrogenasethiol-group reactivity 317-323

Glutathioneglyoxalase I 23-30

Glyceraldehyde 3-phosphate dehydrogenasebinding to muscle 663-667

Glycine max, see Soya beanGlycoproteinTamm-Horsfall, see Tamm-Horsfall glycoprotein

Glycoproteinscentral-nervous-system myelin 205-212, 213-221lectin-binding 205-212, 213-221see also Sialoglycoproteins

Glycosaminoglycansassay methods 91-97

Glyoxalase Imammalian 23-30yeast 23-30

Green pigments (modified porphyrins)allyl-containing drugs 99-103

Guanidine thiocyanatebrain RNA isolation 181-184

Guanine nucleotidesadenylate cyclase 589-594

Guanosine 5'-monophosphateinhibition of IMP dehydrogenase 481-494

Guanosine triphosphate analoguesRNA polymerase 65-71

Haemmodification to green pigments 99-103

Haemoglobinamino acid composition 325-330molecular weight 325-330number of polypeptide chains 325-330tadpole shrimp (Lepidurus) 325-330

HaemsPseudomonas cytochrome oxidase 701-709

Halobacterium halobiumactive site of bacteriorhodopsin 175-178

Heartf,-galactoside-binding lectins 755-758

Heavy chains, see Immunoglobulin heavy chainsHeparan sulphate

fibroblast proteoglycans 669-681fluorimetric assay 91-97oligosaccharide structure and degradation 711-720

Heparinfluorimetric assay 91-97

Heparin-Sepharoseaffinity chromatography of hyaluronidase 531-537

Hepatectomyzinc-binding protein 683-690

Hepatomaaldehyde dehydrogenase 55-64

High-density lipoprotein (HDL1)cholesterol and triacylglycerol contents 83-90rat plasma 83-90

1979

764

INDEX OF SUBJECTS

High-mobility-group protein, see Non-histone proteinHMG 1

Histidine residuepapain active centre 223-231, 369-373

Histidine residuesligands in metalloproteins 127-132

Histocompatibility complexcomplement component C2 and Factor B 615-622

Histone HI subfractionsinteraction with protein HMG 1 657-662

HMG protein, see Non-histone protein HMG IHorseradish peroxidase

indole oxidation 269-276Hyaluronic acid

interaction with gingival proteoglycans 467-470interaction with proteoglycans 669-681

Hyaluronidasebull seminal plasma 531-537dispersal of cumulus oophorus 531-537heparin-Sepharose affinity chromatography 531-537inhibition by carbonyl reagents 531-537

Hydrogen peroxideindole oxidation 269-276

HydrogenaseEscherichia coli 11-22membrane-bound 11-22

Hydroxyapatitebinding to salivary proteins 115-126

1-Hydroxyethane-I,l-diphosphonatealkaline phosphate 73-81

3-Hydroxyprolineprolyl 3-hydroxylase 303-307

Hyperbilirubinaemiaphototherapy of neonatal jaundice 139-146

x-L-Iduronidaseheparan sulphate oligosaccharides 711-720

Immunoglobulinmembrane and secreted 395-403

Immunoglobulin GIself-association 463-465

Immunoglobulin heavy chainsmembrane and secreted 395-403

Immunoglobulin Mmembrane and secreted 395-403

Indoleoxidation by chloroperoxidase 269-276

Indoxyl, see OxindoleInosine 5'-monophosphate

synthesis of derivatives for affinity chromatography481-494

Inosine 5'-monophosphate dehydrogenaseinhibition by GMP 481-494purification from Escherichia coli 481-494subunit structure 481-494

Insectssterol metabolism 495-499

lodothyronine 5'-deiodinaseinhibition by thiouracil derivatives 167-169

Iron atomsClostridium pasteurianum ferredoxin 471-474

Iron-sulphur proteinEscherichia coli hydrogenase 11-22

Vol. 183

Kiwifruit, see Actinidia chinensisKlebsiella aerogenes

D-arabitol dehydrogenase 31-42

Lactate dehydrogenaserabbit and shark 317-323renaturation 317-323

Lanosterol14a-demethylation 309-315

Lectininteraction with N-acetylglucosamine oligosaccharides

133-137Phaseolus vulgaris 381-388vegetable marrow 133-137

Lectin receptorsmyelin 213-221

Lectin-binding proteinscentral-nervous-system myelin 205-212, 213-221

Lectinsassay of nanogram quantities 185-188castor bean 185-188,B-galactoside-binding 755-758heart and skeletal muscle 755-758human and monkey 755-758myelin glycoproteins binding 213-221

Lemina minor, see DuckweedLepidurus apus lubbocki, see Tadpole shrimpLeucoagglutinin

interaction with Tamm-Horsfall glycoprotein 381-388

Phaseolus vulgaris 381-388Light

near-ultraviolet, see Near-ultraviolet lightLipids

Butyrivibrio spp. 691-700Lipoprotein

high-density, see High-density lipoproteinlow-density, see Low-density lipoprotein

Lipoprotein lipasechylomicron triacylglycerol hydrolysis 171-174

Lithium ionsaldehyde dehydrogenase 633-646

Liveraldehyde dehydrogenase 55-64fructose 1 ,6-bisphosphate aldolase 429-444uroporphyrinogen decarboxylase 455-458zinc-binding protein 683-690

Low-density lipoproteinlipid and phospholipid composition 83-90rat plasma 83-90

Lunghydrophobic proteins 731-736

Lymphocytesimmunoglobulin heavy chains 395-403inhibition of agglutinin-induced transformation 381-

388Lysine residue

active site of aldolase 429 444active site of bacteriorhodopsin 175-178glucose 6-phosphate dehydrogenase 297-302

Lysozyme, see Galactosyl-lysozyme

Macroglobulin, see Immunoglobulin M

765

INDEX OF SUBJECTS

Magnesium ionsdeoxyguanosine kinase 547-553ribulose bisphosphate carboxylase/oxygenase 747-750

Manganese ionsribulose bisphosphate carboxylase/oxygenase 747-750

D-MannitolD-arabitol dehydrogenase 31-42

Marrow, vegetable, see Vegetable marrowMembrane

erythrocyte, see Erythrocyte membraneEscherichia coli, see Escherichia coli membranemyelin, see Myelin membranepurple, see Purple membrane

Membrane proteinanion-transport 417-427

Membranesimmunoglobulins 395-403

Menkes' diseasemouse model 721-730

Messenger ribonucleic acidglobin 105-114newt erythropoietic cells 105-114

Metallothioneinisolation from plaice liver 277-283zinc-binding protein 683-690

Metallothioneinscopper-binding proteins 721-730

Metamorphosisbile-salt changes in amphibia 507-511

Methylaminesprotein structure stabilization 317-323

Microbubblesreplicating nuclear DNA 477-480

Microsomal fractionbinding of 6-propyl-2-thiouracil 167-169stearoyl-CoA desaturase 405-415

Mixed-function oxidasescholesterol biosynthesis 309-315

Mucopolysaccharides, see GlycosaminoglycansMuscle

binding of aldolase 663-667fructose 1,6-bisphosphate aldolases 429-444f,-galactoside-binding lectins 755-758skeletal, see Skeletal muscleX-ray diffraction 663-667

Myelinlectin-binding glycoproteins 205-212, 213-221myelin basic proteins 159-162precursor membranes 159-162

Myelin basic proteinpossible identity with calmodulin-binding protein285-295

Myelin basic proteinsmutant mouse brain 159-162

Myelin membranelectin receptors 213-221

Myeloma proteinsimmunoglobulins 395-403

Myofibrilsneutral proteinase 339-347

Near-ultraviolet lightinhibition of ornithine carboxylase induction 179-180inhibition of RNA synthesis 179-180

Neonatal jaundicebilirubin and phototherapy 139-146

Neutral proteinaseCa2l-activated 339-347purification from skeletal muscle 339-347

Newt (Triturus cristatus)erythropoietic cells 105-114globin mRNA 105-114

Nicotiana tabacum, see TobaccoNicotinamide-adenine dinucleotide phosphate (oxidized)

binding site of glucose 6-phosphate dehydrogenase297-302

periodate-oxidized 297-302Nitric oxidePseudomonas cytochrome oxidase haems 701-709

4-Nitrophenyl acetatesubstrate for aldehyde dehydrogenase 459-462

Nitrophenyl esterasealdehyde dehydrogenase 459-462

Non-histone protein HMG (high-mobility-group)linteraction with histone HI subfractions 657-662

Nuclear magnetic resonance ('3C)ficaprenol- 1I characterization 163-165

Nuclear magnetic resonance ('H)histidine residues in metalloproteins 127-132

Nucleihen oviduct retinol-binding proteins 501-506phosphoprotein 147-156Physarumpolycephalum DNA 477-480RNA polymerases 43-54

Nucleotide sequenceschloroplast 5 S rRNA 595-6044.5S RNA from plant chloroplast ribosomes 605-613

Nucleotidesadenylate cyclase 589-594deoxyguanosine kinase 547-553

Nylonalkylation for protein immobilization 445-451

Nylon tubesreactors containing immobilized enzymes 445-451

Ornithine decarboxylaseinhibition of induction 179-180

Oviduct magnumretinol-binding proteins 501-506

Oxidasesmixed-function, see Mixed-function oxidases

Oxindoleformation from indole 269-276

2-Oxoaldehydesglyoxalase I 23-30

Oxygencytochrome c oxidase 519-529

Papainactive centre 223-231, 369-373

Parathyrinalkaline phosphatase 73-81

Parathyroid hormone, see ParathyrinPentitols

Klebsiella aerogenes 31-42Pepsin

erythrocyte membrane anion-transport protein 417-427

1979

766

INDEX OF SUBJECTS

Pepsin Ainhibition and molarity determination 389-394

Peptidesalkaline phosphatases 189-192erythrocyte membrane anion-transport protein 417-

427plasmin assay substrates 555-559

Periodic acid/Schiff reagentfalse positive reaction with protein thiol groups 277-

283Peroxidase, see Horseradish peroxidase and Chloro-

peroxidasePeroxide

indole oxidation 269-276Phaseolus vulgaris, see Dwarf bean and Red kidney beanPhosphatase

alkaline, see Alkaline phosphatasePhosphodiesterase

inhibition of calmodulin activation 285-295Phosphofructokinase

allosteric conformational transition 349-3601,N6-Ethenoadenosine triphosphate binding and inhi-

bition 349-360PhosphonatesGTP analogues and adenylate cyclase 589-594

Phosphoproteinrat liver chromatin 147-156

Phosphorescenceprotein-bound dyes 561-572

Photobilirubins 139-146Physarum polycephalum

replicating nuclear DNA 477-480Phytohaemagglutinin

purification of leucoagglutinin 381-388Phytosterols

dealkylation by insects 495-499Plaice (Pleuronectes platessa)cadmium-binding metallothionein 277-283

Plasmafibronectin 331-337

Plasminassay with 7-(N-succinoylalanylphenylalanyl-lysyl-

amido)-4-methylcoumarin trifluoroacetate salt 555-559

fibrinogen and FR antigen 623-632Pleuronectes platessa, see PlaicePolyacrylamide gels

myelin/concanavalin A binding 205-212Polyguanylate polymerase

bacteriophage Qfl 65-71Polymers

osmotic compression 1-9Poly(methyl methacrylate)

phosphorescence polarization of immobilized dyes 561-572

Polyprenolcharacterization of ficaprenol-l 1 163-165

Polyribosomesnewt erythropoietic cells 105-114

Polysomes, see PolyribosomesPorphyrinogens

uroporphyrinogen decarboxylase 455-458Porphyrins

modified (green pigments) 99-103

Vol. 183

Proline residueprothrombin conformations 513-517

Prolyl 3-hydroxylasechick embryo 303-307partial purification 303-307

n-Propyl 2-pyridyl disulphidereaction with papain active centre 223-231

6-Propyl-2-thiouracilbinding to microsomal fractions 167-169inhibition of iodothyronine 5'-deiodinase 167-169

ProtamineATPase of ATP-G-actin 475-476

Protease, see ProteinaseProtein

cadmium-binding, see Cadmium-binding proteincytosolic, see Cytosolic proteiniron-sulphur, see Iron-sulphur protein'LETS', see Fibronectinmatrix, cartilage see Cartilage matrix proteinmembrane, see Membrane proteinnon-histone, see Non-histone proteinphospho- see Phosphoproteinzinc-binding, see Zinc-binding protein

Protein fluorescenceprothrombin 513-517

Protein structuremethylamine compounds and urea destabilization

317-323Protein synthesis

alkaline phosphate 73-81Proteinase

neutral, see Neutral proteinaseProteinases

acid, see Acid proteinasesactive-centre thiol groups 233-238erythrocyte membrane anion-transport protein 417-

427salivary sediment 115-126serine, see Serine proteinases

Protein-polysaccharides, see ProteoglycansProteins

calmodulin-binding, see Calmodulin-binding proteinscopper-binding, see Copper-binding proteinshydrophobic 731-736immobilization on nylon imidate 445-451lamellated osmiophilic bodies 731-736lectin-binding, see Lectin-binding proteinsmyelin, basic see Myelin basic proteinsmyeloma, see Myeloma proteinsnon-histone chromatin 147-156phosphorescence and fluorescence with dyes 561-572pig lung and surfactant 731-736proline-rich 115-126retinol-binding, see Retinol-binding proteinssalivary 115-126

Proteoglycansdermatan sulphate and heparan sulphate 669-681human gingival epithelium and connective tissue 467-470

interaction with cartilage matrix protein 539-545interaction with hyaluronic acid 467-470skin fibroblasts 669-681tracheal cartilage 539-545

767

INDEX OF SUBJECTS

Proteolysissalivary proteins A and C 115-126

ProthrombinCa2+ and phospholipid binding 513-517metal ion-dependent conformational transition 513-

517protein intrinsic fluorescence 513-517

Pseudomonas aeruginosa N.C.T.C. 6750Pseudomonas cytochrome oxidase 701-709

Pseudomonas cytochrome oxidasehaems interactions with nitric oxide 701-709structure and function 701-709

Psoralen (furocoumarin), see TrioxalenPtychadena, see FrogsPulmonary surfactanthydrophobic proteins 731-736

Purple membranebacteriorhodopsin 175-178

Pyridoxal phosphate3,4-dihydroxyphenylalanine decarboxylase 361-368

Rana catesbeiana, see FrogsRed kidney bean

leucoagglutinin 381-388Rennin, see ChymosinRetinal

binding to bacteriorhodopsin 175-178Retinol-binding proteinshen oviduct 501-506

Retinyl acetatehen oviduct binding proteins 501-506

Rhodopsin, see BacteriorhodopsinRibonuclease

stability of protein structure 317-323Ribonucleic acid

isolation from brain 181-184messenger, see Messenger ribonucleic acidpolyadenylated 105-114, 181-184ribosomal, see Ribosomal ribonucleic acid4.5 S from chloroplast ribosomes 605-613

Ribonucleic acid polymerasebacteriophage Q8 65-71Escherichia coli 255-268GTP analogues 65-71inhibition by 4-chloro-7-nitrobenzofurazan 255-268

Ribonucleic acid polymerasesextraction methods 43-54liver nuclei 43-54

Ribonucleic acid synthesisinhibition by trioxalen plus near-ultraviolet light

179-180Ribosomal ribonucleic acid

5 S, sequences from chloroplasts 595-04Ribosomes

chloroplast 4.5 S RNA 605-613Ribulose bisphosphate carboxylase/oxygenase

effects of Mn2+ and Mg2+ 747-750preparation from soya-bean leaves 747-750

Ricinius communis, see Castor beanRubber plant, see Ficus elastica

Saccharomyces cerevisiaeglyoxalase I 23-30

Salivaacidic proline-rich proteins 115-126

Secobarbitone, see 5-Allyl-5-(1-methylbutyl)barbiturateSeminal plasma

hyaluronidase 53 1-537Serine proteinasescomplement components CTs, C2 and Factor B 615-

622Sialoglycoproteins

abnormal-blood-group-active 193-203erythrocyte membrane 193-203

f8-Sitosterolmetabolism by Tenebrio molitor 495-499

Skeletal muscleneutral proteinase 339-347

Skindeoxyguanosine kinase 547-553fibroblast proteoglycans 669-681

Slime mould, see Physarum polycephalumSoya bean (Glycine max)

ribulose bisphosphatecarboxylase/oxygenase 747-750Spermatozoaecto-ATPase 737-743

Stearoyl-coenzyme A desaturasemicrosomal fraction 405-415regulation by cytosolic protein 405-415

Sterolscholesterol biosynthesis 309-315insect metabolism 495-499

Stigmast-5-enediolssynthesis and insect metabolism 495-499

Subcomponent Clsamino acid and carbohydrate compositions 579-588interactions with other complement components 579-

588purification from bovine complement 579-588

7-(N-Succinoylalanylphenylalanyl-lysylamido)-4-methyl-coumarin trifluoroacetate salt

preparation and plasmin assay 555-559Sulphydryl, see ThiolSuperoxide dismutase

bovine 127-132copper-zinc 127-132yeast 127-132

Surfactant, pulmonary, see Pulmonary surfactantSynovium

collagenase 647-656

Tadpole shrimp (Lepidurus apus lubbocki)haemoglobin (erythrocruorin) 325-330

Tadpolesbile-salt changes during metamorphosis 507-511

Tamm-Horsfall glycoproteininteraction with leucoagglutinin 381-388

Tenebrio molitor,/-sitosterol metabolism 495-499

Tetraethylthiuram disulphide, see DisulfiramThallium ions

aldehyde dehydrogenase 633-646Thiol group

papain active centre 223-231, 369-373RNA polymerase 255-268

1979

768

INDEX OF SUBJECTS

Thiol groupsactive centres of proteinases 233-238aldehyde dehydrogenase 459-462, 751-753

Thionein, see MetallothioneinThiouracil derivatives

inhibition of iodothyronine 5'-deiodinase 167-169Thrombin

fibrinogen and FR antigen 623-632plasmin assay 555-559

Thyroid hormonedeiodination 167-169

Tobacco (Nicotiana tabacum)chloroplast 5 S rRNA sequences 595-6044.5 S rRNA from chloroplasts 605-613

Triacylglycerolhydrolysis by lipoprotein lipase 171-174

3,3',5'-Tri-iodothyroninemicrosomal binding of thiouracil 167-169

Trimethylamine N-oxideprotein structure stabilization 317-323

Trioxalen (trimethylpsoralen)inhibition of ornithine decarboxylase induction 179-

180inhibition of RNA synthesis 179-180

Tris ionsaldehyde dehydrogenase 633-646

Triturus cristatus, see Newt

Ultraviolet light, see Near-ultraviolet lightUrea

protein structure and function 317-323Urease

immobilization on nylon imidate 445-451

Urokinaseplasmin assay 555-559

Urokinase therapyFR antigen 623-632

Uronic acidsheparan sulphate oligosaccharides

Uroporphyrinogen decarboxylaseporphyrinogens 455-458rat liver supernatant 455-458

Uroporphyrinogensuroporphyrinogen decarboxylase

711-720

455-458

Vegetable marrow (Cucurbita pepo)lectin 133-137

Viciafaba, see Broad beanVitamin A statushen oviduct retinol-binding proteins 501-506

Wheat-germaspartate transcarbamoylase 239-245, 247-254

Yeastaldehyde dehydrogenase 633-646

Yeast (Candida utilis)glucose 6-phosphate dehydrogenase 297-302

Yeast (Saccharontvces cerevisiae)glyoxalase I 23-30

Yellow mealworm, see Tenebrio molitor

Zinc-binding proteinamino acid composition 683-690purification from regenerating rat liver 683-690

Vol. 183

769

The

BIOCHEMICAL

JOURNALMolecular Aspects

Volume 183

EDITORIAL BOARD

ChairmanJ. T. Dingle

Deputy ChairmenJ. A. LucyC. I. PogsonA. J. KennyJ. B. Clark

Editorial ManagerA. G. J. Evans

P. M. Bayley*J. W. BradbeerR. C. BrayJ. W. BridgesD. N. BrindleyH. G. BrittonK. BrocklehurstR. B. CainB. A. CookeA. J. Cornish-BowdenD. D. DaviesR. T. DeanR. M. DentonF. M. DickinsonG. J. DuttonP. C. EngelJ. E. FothergillJ. L. Gordon

D. E. GriffithsL. A. GrivellB. A. HaddockL. HueP. LundR. M. MarchbanksG. MurphyN. B. MyantK. B. M. ReidD. RobinsonD. SchuisterJ. E. ScottS. P. Spragg*D. R. StanworthM. J. A. TannerR. T. Walker

* Nominated by the BritishBiophysical Society

Overseas Advisory Panel

H. Beinert (U.S.A.), H. F. DeLuca (U.S.A.), W. Fiers (Belgium), R. W. Hanson (U.S.A.),0. Hayaishi (Japan), B. Hess (Germany), D. B. Keech (Australia), T. C. Laurent (Sweden),L. F. Leloir (Argentina), R. Ross (U.S.A.), M. Schramm (Israel), A. Tissibres (Switzerland),D. Trentham (U.S.A.), A. D. Vinogradov (U.S.S.R.), 0. Wieland (Germany)

LeEMlC4e

tts London : The Biochemical Society s) 1 979

1979

O.,

THE BIOCHEMICAL SOCIETY, 7 WARWICK COURT, LONDON WC1R 5DP

ISSN: 0306-3275

Printed in Great Britain by Spottiswoode Ballantyne Ltd.Colchester and London

ACKNOWLEDGEMENT TO REFEREES

The Editorial Board of the Biochemical Journal gratefully acknowledges the assistancegiven during the 1978-79 academic year by the following referees:

E. P. Abraham B. Billing M. A. CawthorneP. S. Agutter D. Billington E. M. ChanceS. Ainsworth G. D. Birnie D. ChapmanM. Akhtar J. 0. Bishop J. B. ChappellS. Y. Ali N. Blackburn R. CharlesD. Allan J. A. Blair P. A. CharlwoodA. Allen C. C. F. Blake J. ChayenA. K. Allen R. Bonnett C. J. ChestertonJ. C. Allen R. Booth W. W. ChristieR. P. Ambler R. F. G. Booth J. B. CleggJ. C. Anderson N. M. Borthwick M. J. ClemensP. Andrews I. A. D. Bouchier G. M. CloreD. J. Anstee D. H. Boxer S. CockcroftC. Anthony C. A. R. Boyd A. J. CofferJ. F. Antoniw G. S. Boyd J. R. CogginsH. R. V. Arnstein E. M. Bradbury G. M. CohenP. Ashby H. Braunsberg P. CohenS. J. H. Ashcroft H. G. Bray R. ColemanC. C. Ashley I. Bremner J. ConchieE. D. T. Atkins K. Brocklehurst G. M. W. CookG. L. Atkins J. R. Bronk B. A. CookeA. Atkinson P. Brookes H. G. CooreM. Atwood C. J. W. Brooks J. G. Coote

H. S. BachelardJ. S. D. BaconA. A.-B. BadawyA. J. BaileyE. BaileyG. S. BaileyG. D. BairdC. W. BamforthA. D. BanghamB. E. C. BanksJ. BarberA. N. BarclayW. G. BardsleyT. BarkasM. J. BarnesA. J. BarrettJ. BarrettW. BartleyJ. M. BasfordM. BaylissG. BeddardT. J. C. BeebeeR. B. BeecheyJ. G. BeeleyE. A. BellD. S. BendallJ. P. BennettM. J. BerridgeC. S. Berry

G. T. BrooksE. G. BrownS. B. BrownR. W. BrownseyK. R. BruckdorferD. BrundishC. J. BrutonJ. BryantC. F. A. BryceJ. D. Bu'lockB. BurchellK. BurdettR. H. BurdonR. BurgoyneD. C. BurkeK. BurtonA. F. BuryP. H. W. ButterworthP. J. ButterworthP. J. Buttery

R. CammackA. M. CampbellM. CampbellD. J. CandyM. CannonB. CaponE. M. CareyC. J. CarterT. Cawston

(iii)

D. B. CoultD. CoxR. A. CoxM. J. C. CrabbeB. CrabtreeR. K. CraigM. A. CrawfordN. CrawfordJ. M. CreethG. W. CrosbieM. J. CrumptonA. CryerE. CundliffeV. J. CunninghamL. Cuzner

K. DalzielN. E. DanceP. D'Arcy HartD. R. DaviesP. DaviesR. C. DaviesA. N. DavisonE. A. DawesA. P. DawsonR. M. C. DawsonR. T. DeanH. T. DelvesF. De MatteisJ. J. M. de Vijlder

ACKNOWLEDGEMENT TO REFEREES

A. J. DicksonI. DicksonR. DilsH. B. F. DixonK. S. DodgsonA. S. R. DonaldI. A. DonaldsonS. DoonanV. C. DuanceR. J. S. DuncanJ. P. Durham

J. S. EasterbyJ. E. EastoeA. A. EddyJ. EdwardsP. A. EdwardsR. A. EisenthalG. H. ElderD. J. EllarK. R. F. ElliottP. J. EnglandM. B. EnserM. P. EsnoufM. C. W. EvansS. EvansW. H. Evans

R. B. FearsJ. FeeneyA. FeinsteinH. FellS. FergusonE. B. FernH. N. FernleyJ. B. C. FindlayJ. B. FineanR. J. FlowerB. FolkesP. J. FordJ. E. FothergillD R. FraserK. N. FraynN. FrearsonR. B. FreedmanD. J. Fry

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B. A. HaddockC. N. HalesA. P. HalestrapS. E. HalfordL. HallI. W. HalliburtonT. HallinanB. HalliwellW. A. HamiltonJ. B. HarborneJ. J. HardingT. E. HardinghamK. G. HardyR. A. HarknessE. J. HarrisP. HarrisonR. HarrisonR. A. P. Harrison

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M. I. PageR. H. PainV. M. PainA. J. PaineJ. H. ParishD. V. ParkeD. S. ParkerR. M. E. ParkhouseD. S. ParsonsC. A. PasternakA. J. PatelJ. V. F. PatersonD. PeacockW. S. PeartJ. L. PeelA. E. PeggI. W. Percy-RobbS. V. PerryG. W. PettigrewC. F. PhelpsJ. H. PhillipsR. Pitt-RiversJ. D. PittsR. J. PollittJ. F. PowellK. PowellR. PowlsN. C. Price

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D. W. YatesD. W. YoungJ. D. YoungJ. L. Young

vi