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So, What’s Aging?
11
Aging is a shift in our reality!
So What’s Reality?Created by Dr. Edward Lakatta, Dr. Harold Spurgeon, and Dr. Victor Maltsev
Reality emerges from a mutually coupled (enslaved) system of DNA
and its environment
DNA
Environment
Environment
Environment Environm
ent
2
Sun, planets, Moon, asteroids, Sputnik
O2, CO2, smoke
Geographic, climate, radiation, pollutions, gravity
Traditions, Religion, “Mandates”
Friends, Relatives, Pets, Plants, Bacteria, Viruses
Soma, Psyche, and emergent characteristics: Personality, Cognition, Innate Brain, Behavior, Lifestyle, Nutrition, Exercise
Organ-to-organ communication: Brain-Nerves, Cardiovascular–circulation, Endocrine-circulating goodies
Extracellular matrix
Organelles, mitochondrial DNA, microRNA
Chromatin, Transcription factors, HATS, HDACS
Heredity
3
Reality Is A System of Mutually Enslaved DNA and its Environment
DNA
4
DNA
Aging is a constellation of failures in DNA-Environment system over time
Failing InteractionsD SignalsD Sensing of SignalsD Signal TransmissionD Response to SignalsD ProteostasisEnergy rundown
Aging is:A constellation of DNA-Environment system Failures over time, that result in Altered Cell Tissue and Organismal Phenotype Characteristics
CellsTissuesOrgansOrganism
Images from Mechanisms of Aging5
SO! Is Aging, per
se, A Disease?
6
“Aging and disease are not synonymous.
There are processes of
aging and etiologies of disease. The relationship
between the two are important,
but not inevitable”
Nathan Shock, Ann. Rev.Physiol. 1961 7
8
“... to draw a
distinction between
disease and normal aging is to attempt to
separate the undefined from
the undefinable”
J.G. Evans, Research and The Aging Population 19889
What’s Reality?
So
THIS is REALITY!