will be adminis tercd in accordance '",i th the terms ,nu conditions as set

931 ~~03 . '. '?S \ SlP 80 791S

AGENCY FOR INTERNATIONAL DEVELOPMENT

WASHINGTON. D.C. ZO'ZJ

This Grant is effective and oblj,gation is madE' as of the dote "f

Pursuant to the authority contained in the Foreign Assistance Act

Subj~ct: Grant No, AID/ta-G ],2~~

PIO/T No. 931-11-99~-On3-73­

3168641

Association of Biological Standardization (hereinafter referred to as

Pro:e5So~ R. H. Regawey Int rnational Association 6f Biological Standardization Jnstit~t d'hl8icne #1122 Geneva, Switzp.rJand

referred to as "A.I.D." or "Grantor") hereby grants to the International

this letter and shall apply to comni.tments !ilade by the Grantee in

of 1961, as amended, the Agency for International Development Olereinafter

26, 1975, 3S more fully described in the attachment to this Grant

D~ar Prof. Reg~mey:

Isle of Han, United Kingdom from September 21, 1975 rhr(lu~.h Septenbel"

furtherance of progL'arn ohjectives from SE'ptember 1, 1975 thr.ollgh

April 1, 1976. This Gr.ant is made to lABS on condition that the fUi1qs

forth in Attachment "A" entitled "Program DescripUo~l", l~ttach!lP:lt

entitled "Program Description."

Hundred Dollars) for the purpos3 of conducting a conference on the

"B" enti tled "Standard Provisions", and Attachment "e" entitled "Payment

Provisions", which have been agr~ed to by your or~anization.

..f TAB~' .or "Gr~ntee") the sum Of $17,5'00 (Seventeen Thousand Five

-2­

.•_ Co..... ., \,; ..P' '.)~'" '") sigo tr.e Statement of Assurance of Compliance, enclosed

herei:l, 2-d ttl2 original and seven (7) copies of this letter to acknow­

ledge your aCCe?LltlCe of the conditions under which these funds have

been granted.

Please return the State~ent of Assurance of Compliance and the

origi~nl and six (6) copies of this Grant to the Office of Contract

v. . p ~

Officer--~~a;::;-n~t

Technical Assistance Branch Central Operations Division Office of Contract Manag~ment

Attach~ents: Statement of Assurance of Compliance A. Progran Descri~tlon

B. Standard Provisions C. Paynent Provision~,

ACCEPTED:

STA~IDARDIZATION

(H. H. Regame,)

ASSOCIATION OF BIOLOGICAL

..

I. '.';:"

I L._ .. Yt'f'

_.--._.. _ - _ •• ........... _ -. - ••••.0 •••. ~ __..__ ~.~.

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PROGlLV·f DESCHTPnO~

A. Purpose of Gr~n~

The pur?os~ of this Grant is to provide SUPPl)ct for a Confere:1ce

on Or;,:,l and Non-Parenteral Vaccination to: 1) dissi:mlnate the kn(l~·!ledge

that has aCl:umu1ated in this researeh field, 2) present sci.ent Eic

dissertation on re3€arch activities, 3) lay dm.;n CO:lcrete plans f·:w

"'lture rest?arL'h trends in ;t.his field and 4) pr('p"re ~1l1d distribute the

~~Jings. The seminar will be held on th~ Isl~ of ~2n, United

,',Lll<:jd;)m at the 14th Congress of the Intern.:.1tiol1.:.11 .\ssociaticn of

Biological Standardization fr0m September 21, 1975 through Septembei

26, 1975.

B. ,~E£c~~~_g_~_i~~s_t_i~~~

The specific objectives of this Grant are as follows:

1. To evaluate the state of the art as it presently exists and

indicate areas in which there is reason to believe some of the develop­

ments may be applied.

2. To make recommendations un promi.sing res~arch Jevelopment that

should be carried fan-lard and on establ ishing a system of connnunicCltion

between researchers in these fields.

To achieve the above objectives, the Grantee shall carry out the

following activities with funds provided by this Grant:

1. Issue invitations to biological and veterinary scientists

from the following LDCs and institution:

-2-

No.

1 ~liger ia

1

1

2.

Panama

Colombia

Texas A & M

Provide t~avel and ~er diem for the participants indicated

above and publish conference proceedings.

3. Hold a Conference in accordance with the following program

agenda:

Tentative Program Vaccination by the non-parenteral route

Human Veterinary

H 1.0 Mycoplasm3 V 1. 0 Bae teria 1.1 Brucella

H 2.0 Bacteria 1.2 Erysipelas-SI,j'ine 2.1 Typhoid 1.3 Streptococcus-Jowl Abscess 2.2 Cholera (Pharyngeal Spray) 2.3 Coli 1.4 Vibrio-Sheep 2.4 Shigella 2.5 Tularaemia V 2.0 Virus 2.6 Pertussis 2.1 Avian Encephalorny~litis

2.7 BCG (selection reserved) 2.2 ~ewcastle Disease 2.3 Infectious Bronchitis

H 3.0 Toxoid:; 2.4 Infectious Laryngotracheitis 3.1 Diphtheria 2.5 Infectious Bursal Disease 3.2 Tetanus 2.6 Fm.,rlpox 3.3 Cholera 2.7 Felioe Panleukopenia

2.8 Rabies H 4.0 Virus 2.9 Transmissible Gastroenteritis ­

4.1 Adena Swine

-j ­

4.2 Rubella 4.3 Influenza 4.4 RS 4.5 Polio (selection reserved) 4.6 S;nallpox (not cutant:ous)

PROGRAH

1.1 Research on rcspir:.J.tory using speay

VACCINATION BY THE

2.10 Calf Reovirus (Scours) 2.11 Encerh~lomyoclrditis-Virusin mice 2.1:2­ I Im-BVD 2.13 Fish Dise<lst'S ') j t. __ .. '-t In[lucn~c - ~ice and Ferrets

~mN-PARE;';J.·ERAL ROUTE

Opening Address A. B. SABIN

Session 1

humoral and cellular immunity in th~

tr<:1cts of anir.::lls vaccinated crally ~!. SALETTI

1.2 Non-parenteral vaccines for veterinary use in UK G. FRERICHS

1.3 Viral vaccination by the non-parenteral route: pre-requisite factors and characteristics of immune response

1.4 Varcina~ion hy the non-parenter;}1 route on virus diseases in the veterinary field

1.5 Report on avian products standardization comrnit­t'2e (Chain:wn: Nr. F.. C. Hulse)

1,6 Research and deve~ ,)!ll:wnt of unc.:on'lcntional systems for immunization

Session 2

2.1 Immunization by aelo::;ol of anti.:-::l'niqwcoccal lyo­phili7.ed vaccine

2.2 Streptococcal vaccine administered by nasophar­,yngeal spray

2.3 Assay of non-parenleral vac~ination against brucella

2.4 Effectiveness of orally administered Bordetella pertussis vaccine in mice

P. L. OGEA

1. HENASSE

B. R. BURt-lESTER

N. X. KO~rnERUP

R. FONTANGES

R. H. WALD~Lo\N

c. PILET

H. HOF

-4­

2.5 Experiences with orally administered Bordetella p~rttJ2_~j~ vaccines in babies N. N.

2.6 Oral i: .. ~\tnization =,gainst tetanus G. BALJER

2.7 StanJar~ization of Escherichia coli oral vaccines O. FELSENFELD

Session 3

3.1 E:q)(~rir;:0nts .with a model for aerosol immunization of :nice :~,ld swine against ErY$ipelothrix insid10_s3 K. PETZOLDT

3.2 Potency testing of inactivated oral vaccines for human l!S.~ I. JOO

3.3 FL·H tri,]l '.;Lt!l oral typ!loid vaccine J. H BORGONO

3.4 VQccl~~ti0n 3~2inst typhoid fever with an atten­uated oral vaccine R. GERHAJ.'HER

3.5 Aerosol EeG used as immunotherapy of patients with lung cancer R. H. H'ALDHAN

Session 4

~.l Immunity studies in calves vaccinated with a multivalent live respiratory vaccine composed of TBR parainfluenza 3 and bovine adenovirus type 3 N. ZYGRAICH

4.2 Compared efficiency with a killed, a living vaccine and an antigenic fraction in the innnunization of the mouse, by oral canal R. FONTANGES

4.1 Live attenuated parainfluenza vaccine: studies in ferrets C. C. ~\SCOLI

4.4 Studies in ferrets with live attenuated influenza virus A. DELB-r

Session 5

5.1 Problems in non-parenteral administration of'viral vaccines with particu~ar reference to rubella D. B. FREESTONE

5.2 Oral immunization against pox: studies on fowlpox in the drinking ~ ...a::er A. HAYR

5.3 Further studies on vaccination against fm.flpox in the dT. in' in w' t 1: 1. HENASSE

5.4 Oral vaccinati n ageinst smallpox in man N. N.

5.5 Studi S 0;1 'l cin~tion a~ i st .l~rek's di.sc sc by the oral route I. HENASSE

5.6 Application of the Tur~ey erpesvirus vaccine by the aerag nic route for' the pr lention of Harek' s disease C. S. EIDSON

I5.7 Intramammary v ccinatLon against transmissible Igast~o neerllis of s~ine !V. CABASSO

! 5.8 TmlU 1.2~~t.:io uf dld (uxe ag·.lnst rabL"s : N. N.

I

5.9 Intranasal vaccination of cattle against IBR and P13: field pnd laboratory observations in dairy, beef and neonatal calf populations J. D. TODD

5.10 Imrnlne response to orally administered calf reovirus and coronavirus vaccine C. A. HEBUS

Session 6

6.1 Evaluation of virus strains used in live influenza vaccines C. HUYGELEN

6.2 Pathogenicity, immunog n' ci ty and genetic stability of cold inhibitor-resistant mutant of influenza H)N2 in mice and ferrets H. ZAVADfJVA

6.3 Experience of nasal application of inactivated influen~a vaccine H. FUKUMI

6.4 I~nunization of man and animals agRinst influenza by oral and intranasal route A. BOUDREAULT

6.5 The use of live attenuated influenza vaccine (ts-l) (E) in Inan J. M. G~.,rALT\~EY

6.6 Use of live attenuated influenza vaccine in normal and asthmatic adults E. C. nICK

6.7 Live attenuated parainfluenza vaccine: studies in man C. HASCOLl

6.8 Production and biological chAracterization of live recombinant A/Finla~d 4/74 vaccine D. HcCAHON

6.9

7.2

7.1

6.1'1

8.4

7.4

7.5

7.3

7.6

8.1

S ..3

8.2

-6­

-ntural ch lleng of subjo? ts v<l:dnCltion with WRL C. A. HORRiS

l05 st r[lin 11 ve iufluenz vaccine in resident'ial community

6.10 Clinical ... rials with intranasa'lly adminis tered WRL 105 strain 1 've influenza vaccine in volunteers D. B. FREESTONE

Comparison of ~ methods of intranasal vaccination with recombinant \~RT. 105 stnlin live attenuated in­fluenza vaccine W. G. WHiTE

Session 7

~vian infe_tiuu' ron hitis vaccine: primordial or de ivcd virus?

The p~oposed international standard of infectious bronchitis vaccine (live) C. FRERICHS

Studies on vaccination against laryngotracheitis in the drinking water A. SEHIENIS

Evaluation of a live v;irus vac:ci.lle agaiust JBDlin­fectious bursal disease E. VIELITZ

Infectious bursal disease vaccine - some remarks on production and control L. NARDELLI

Standards for vaccines against infectious bursal disease D. THORNTON

Sessirn 3

Dry aerosol vaccination against Newcastle disease R. FONTl~NGES

Safety and activity controls on chickens J. FOUR.lIlIER

Serologic.al anst,mrs on chicks D. GAUDRY

Aerosol administration of Newcastle disease vaccines at one ddy of age S. H. KLEVEN

8.5 Oral and aerosol vaccines for Newcastle disease R. P. HANSON

8.6 Studies on vaccination against Newca£tle disease widl the Komar.ov s train of virus in the drinking water A. SEUtENIS

S.il Local immunity against Newcastle disease A. KOliN

8.8 'Newcastle disease: environmental and host influences on immunity induced by :lon-parenteral vaccination R. HANSON

I Grnotee will provid , no later than six months after co pletion

of the conference, fifty copies of the proceedings in the English

langu ge acc r ling to th. standard format of the lABS Congress Proc cd fngs.

In addition, Grantee will provide copies of TA/AGR selected papers

of the confereoce. These reports will be submitted to the TA/AGR

!technical specialist stated below: .I, D~. ~cls Konncrup, TA/AGR Dep~rtmcnt of State Agency for International Development Washington, D.C. 20523

E. Budget

The funds provided herein shall be used to finance the following

items:

Travel $ 9,930

Other Direct Costs 5,250

Publication expenses 2,320

TOTAL $17,500

The Grantee may not exceed the total amount of the budget.

Adjustmen,ts among the line items are unrestricted.

,I

-' r"'

Attachment Bt·· : #

0.. . ... f •

$/ Speclfic Support / 10/15/74

,

SfANDA~O PROVISIONS

a. Allowable Costs and Payment (Oct. 1974)

The Gl~antee shall be reimbursj:!d for costs incurred in cilrryin~l out the PUl"pOSeS of this Grant which are detennined by the Grant Officer to be allowable in accordance with the terms of this Grant and Subpart 15.2 of the Federal Procurement Regulations (FPR) (Principles and Procedures for use in Cost Reimbursement Type Supply and Research Contracts with Comn'ercial Organizations)* in effect on the date of, this Grant. Paymentof allowable costs shall be in accord~nce with Attachment C of this Grant.

[*If this Grant is made to a university, the applicable cost principles are "Federal Hanagement Circular, 73-8 (Cost Principles for Educational Institutions)" instead of Subpart 15.2 of the FPR as cited above]

b. Accounting, Records, and Audit (Oct. 1974)

The Grantee shall maintain books, records, documents, and other evidence in accordance with the Grantee's usual accounting procedur'es to suffi ­ciently substantiate charges to the grant. The Grantea shall preserveand make available such records for examination and audit by AID and the Comptroller General Qf the United States, or th~ir authorized represen­tatives (1) until the expiration of three years from the date of term­ination of the program and (2) for such longer period, if any, as is required to complete an audit and to resolve all questions concerning expenditures unles~ written approval has been obtained from the AID Grant Officer to dispose of the records. AID follows generally accepted auditing practices in determining that there is proper accounting and uSP. of grant funds. The Grantee agre~s to include the requirements of this clause in any subordinate agreement hereunder.

c. Re fund s (Oc t. 1974)

(1) If use of the Grant funds results in accrual of interest to . 1e lr,~n te\~ or to any other person to whom Grantee makes such funds dVl' able in carrying out the purposes of this Grant, Grantee shpllrefund to AID an amount equivalent to the amount of interest accrued.

(2) Funds obligated hereunder but not disbursed to the Grantee at the time the grant. expires or is terminated, shall revert to AID, except fot' funds encumbered by the Grantee by a le~ill1y bindin r)

transaction applicable to this Grant. Any funds disbursed to but not. expcndt:d by the Grantee at the time of expiration or terrllinat'ion of thr:: Grant shall be refunded to AID.

-1­

."" ,," ...

(.i) If, at any time during the' life of the Grant, it 'is cJeterallined by AID that funds prov'ided under'the Grant have baen expended for purposes nul: in accordance with the terms of the Grant, the Grantee sh.1l "CLHlI.J ~uch amounts to AID.

d. I_yulll Opportuni ty EmploYment (Oct. 1974)

I, th re~Jd rd to the employment of persons in the U. S. under th i s Grant~ Gl'antee aarees to take all. reasonable steps to ensure equality of opportunity in its employment practices without re9ard to race, reli9ion. ',C'X, color or national origin of such persons and that, in accordance \\'Hh Ti t 1e V1 of the Ci vil Ri ghts Act of 1964, when work funded by th is Grant h performed in the U.S. no person shall, on the grounds ,of. race, re·ic:rion. sex. color or national origin, be excluded from participation, be denied benefits, or be subjected to discrimination. In addition, the ~jral1tee agrees to comply in accordance with its written assurance,of cOlrjJlionce, \·,ith the provisions of Part 209 of Chapter II, Title 22 of the Code of Federal Regulations, entitled lINon-Discrim'inatior. in federally Ass is ted Programs of the Agency for International Development - Effectuation . of Title VI of the Civil Rights Act of 1964. 11

e. Terlllination (Oct. 1974)

Th; s Grant llld}' be terminated' at any time, in whole or in part, by the Gran~ Off;c~r upon written notice to the Grantee) whenever for any reason he shall determine that such tenmination is in the best interest of the (jovernn-ent. Upon receipt of and in accordance with such notice, the Grdntee shall forthwith take 1~diate action to minimize all e)(pen­c.1itures and ob1 igations financed by this Grant, and shan cancel such' unliquiddted obligations whenever possible. Except a!. provided Dl-i-d1, no fUI-ther reimbursement shall be made after the effective date of termintltion, and the Grantee ~hall within thrity (30) cillp.ndar day~. ilftfir the effecti ve date of such tennination repay to the Grantor a11 unex~,end(!d

portions 01; funds theretofore paid by the Grantor to the Grantee which are n t otherwise obligated by a legally'binding transaction applicable to this Grant. Should the funds paid by the Grantor to the Grantee prior to the effect:ve date of this termination of this Grant. be insufficient to cover the Grantee's obligations pursuant to the aforementioned legally

-:ndir.lJ tl'ansaction, the Grantee Ny submit to the Grentcr' '../itr"n (90) -dl ndar ddY~ after the effective date of such termination a writte~ tlaim Qverin, sllch obligations, and, subject to the limitations contained in

',1 ,:'JI1 t. the Grant Offi cer shall determi ne the amount or amounts to be ;la i by the Grilntor to the Grantee under such cla im.

i, Officials Not to Benefit (Oct. 1974)•

~J I '1Ih~I' (,f or delegate to Congress or resident conrnis$ioner shall be ~d~lttcd to ijny share or part of this Grant or to any benefit that may M"'':t. therefrom~ but this provision shall not be construed to ~xtend tc ttl 1., Gr'llnt if made \'Jith a corporation for its general henefit.

-2- Beat A'f'ailable Docum~t I.!:::====;........:-=---====~=---'..::--====~~ __...='"""'~~~.....--~~----~:A..--_---~--'.

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·.}.I,li:tnt Against Contingent ,Fee (Oct. )974). ,"

, i.r·tl"e \<Jarrdnts that no person or selling agency has t)(~en employ<;,d

.". ,d1necl to solicit or secure this Grant upon an agreement' or under- " for a commissiol1, percentage. brokerag(!, or contingent f~e .

,:·;·:u~~) t Idln:l fi de emp10yees or bona fide es tab l·i shed cplilIllerci a1 or: sc11 i ng d:;('nl:~'" 11II1irltdil1ed by the, Grantee for the purpose of r,.ecurin~ busines~.

-or hll!oIrh (iI' violdtion of this warranty~ AID shall nllv(' thp., riuht to L,"1',1 ;!·I:. ('r-lint without1 liability or, in its discretiun. ttl deduct frolll : It' l;I'.1r":f <l1,IUllt:, or otherwise recover, the full.amount of each UHllllli~;~'iorl,

l".'·'·cen;,< ~l: I :'rokc:rdge, ur. contingent fee. '

r.. ~ I L1biJ2!l (Oct. 1974)

/\TD does !lE JSSlJme liability with respect'to any claims for damages .:lr'j i 'I.) ou i. of work supported by its' grants.

1. !.It!It.f1dlllent '(Oct. 1974)

The GI-.1IlL l\~reelllent may be amended by fonnal modifications to the basic . r( nt dOCUlI ent or by means of an exchange of letters between the AID Grdnt Officer ~nd an apprQpriate official of the Grantee•

.i. ~rdnl...fuL~'ent. (O~t. '1974)

',he ]'! U r to the Grantee signed by the Grant Officer. the Pro'JNliI DeSCI"I'JUOn and the Standar3 Provisions which have been rcvi(,~/l.!d ..,nll ,1Ijfl''2C\ ,:, by the Grantee. cons ti tute th~ Grant Agree/llf~1l t.

~. 'a-,ees (DeL 197~)

I\I~Y no lI.:e ~'tVen by any of the parties'hereunder. shall be sYfficient onlyi t ':1 \oJrit'lng and delivered in person or sent by telegrilpn, cable, l't.~"i·- toren or reUlllar mail as follows:

:0 tlh' coyniZ<lnt /dO Grant 'Officer

T Jrantee - At Grdnteels adt1ress S,lOwn in this Gran~, or tv ,l.l I .Ll'l' dldt'c"s LJ5 either party shall designate by notice given llS i1 '1,:'11, r '"d')' 'e!. ,'.lo·,ices hereunder. shall oe effective when delivered in -lIeu!' I(lnee 1',Iith thl::i clause or on the effective date of the noticc, ..":1.; eVLr 1: It ter.

-3-

Beat Ayailable Documant ,

\.~. .. i .; ~. r ~ s r~s ·r',:~t i (;'1:-:

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~hel"'o 1 ;~i~:jt ~l c :.:'it.~,'": ~~~~:::"J

have ~ (C G:': :1'.1.:,: t. ion 5 0.'1.:, '. ! ,~~:: ':!lH~n 1.

-- ­ '--';'_':"-':"- ;.......:_.::..1. (1) T:,e Grantee ~9;'.:'··5 1.0 ·_ra'.I ..:~ :;y tr,,;: r.~5t d'i .. C.~ 1;"1(1

expi:dit GUS re' te" ,and to 'J52 lr~.:.s t:::.", .(::-~: : :.:'..l ~l":-,':.:i' r:'}'Chll U!1125S such use w,fil result in unl"e.:son:w·iC d:L:y or incr~:'(o:E'd Cost3.

sc~~du1ed but does not are SOu9ht;

2. ~her2 ....._ C';J2r~.1 rc :;;-~', :-Pl:t'ir,;, 0:" G:":~r

(a) All ;nterr.st~cr. 1 3;1" t:--.)·:'::~ 1..1;dc;r th1:. (.-::'It s:oa 1 u= lil.~ae on UniteCl States flcs c.'·i'c';:.. E;....::):~\.r,:- -::0 ~;,i;: J;'; '.~ill

U,·-_·· ""I"I-··'·d 1'", '"11'" ":O~·lO\.ll·n'" s: .. ,,··:~.,- ··v· .... ·,~,'.J ",'.,." "':-e r·",.­ ~ r::..rC Un C I; ,_, _ I . ~ ~ I .... ~ '" I .J" ~ i:' U • " ._-.: ... ' •. .. I. ...... I -' ~ - '-' -

tifies to trle facts in tile v: .',:' :;r or c,tner' d")c'-"'~"~s re-:3.1r.::.:d 0:' ~I rt of his Grant recGr'ds.to SUDpJ~ nis cic~r;, fo~' r'e;;-r:j.:r5::-.,<:nt :.tild fol' post audit: ! '

, ,

features of a United Sta'~es c2.r-;£;r" 'f:'o:Jla ~:1'_::"~'~;Je l,oiEn or pl't;'.'2nt the satisfactory perfonnance of cffici~l b 5in_s~;

3. Where a ~ch~duied f1i;ht by a United Stutes carrier is celayed because of ',.,.ea~r::--, :":-:"'j~::~C31. e'i (':'I~:" cor:di~i0ns to suer. an 2x-cent that use of a non-ur.i ~-=~ Stc.~es Carrier is in the (Il)V2rnii.ent's intere5t;

4. Whe'-e "Cl~ dppr'(~lriJte ciass of accoidotl.1tions is ~ ..':::':-:uj~ -·n botn United 5-=:1t~s ~r.ct :1o,l-"nited Stat.es c:'iril2rs, ~ut t.he .. :;:: ,:,,; ;:".,: ';nited States ·.:: .... r~<;;-- Yliii r:::')'.J1t in hiSiler total U:.ited s:~~,::; :'-., Jr' cost to thi: ,~·,-a;·,r. C ;: lli --,.jditional fler d;~~ or o.. her e:ql~',:ibt und

5. Where the a:prc0riate class of acco~mod~~~ons 15 a~ail~J"e only on a nc~-~ ,ited St'~es cal'rier ~~d tne cost cf trans­pcr:at:c:I '::J r21at~d ~e'r ~':7, 0,1 : ..•~ non-U.S. C2r"ier is ie-s,:, t~,crl the -., -' c~:~ -; .::·.~~1::~12 ::':'':·~··T:-''::.:i0,r:S -- cr,·j~he~" t:lc:,:; nn a Ui1ited St~t~5 carri f: ian.: r €: ' it. ~ .;: .\ ;.: :; r d·j:;:'.

(:» All ir;-ern3ti0·'~: a~r shi;J;'!'e~ts ,n~2t' :(,"5 ,;:r"nt ~~J11 bz -~~~ en t'-~:~~ ~~~:=~ ~~~~ ca,-rler'S ~~1~5~ :hi~~~,:~ ~~ul~1) 10 t' e ju-\s~~r: -:- ~rl~ 1"'" .::.-'~..:: t·~~ ·:::·;.J~/:=:d :.r, ..;rol~~.:::':i.ablf~ ti:'.:-:: ,:,·.';jti~9

.:! L!nitec ·.d':'~:i carrir;r- ::i:.-:;;-- c.v ~.jlnt 07' Or'; ~n Of 'JJr,:':11;:,-:,.;:-,t, proviC2d t~~: ~~e Gr_n~ __ ~~r:1f~~s to tn2 rac~s in ~~8 YG~c~(rs or o~her doct.:7", r.~3 ret.ained'::5 pdrt 07 thE: Gr.::r.~. r,:':']rcs to SIJ;Jport Lis claim for reiD~urse~ent anj for post audit.

(2) Trz~cl 211ow~~:e: s~~11 be rei~bur~5d in accordance with the Fed~ral Travel Regulati0~S (fT~).

(1) If it. 'js :.:P. Gr.n: e's inte'ntion tc ~ entify AID's contri­bution a any p blL: ior "';'S Jltin froll't is r_nt, .. h2 rantee shall cons' it ....Jit r. 0 or " 02 n,:'i'~I~_ J" tile ac~:n:J.1 " .. -:m I: p'ior 0 Po Iblication.

(2) The Gra~t~. s'.'l1 provide the Pro~ect Nanager with one copy of all published wo~ s de/~~oped undG~ th~ Gr~nt. The Gr·ntee shall provide the Project ~lanager ~,;i th 1'1 sts or" otner written work' produced under the Grant.

(3) In tJle eve It grai t funds rE: used to 'ndervll'He the cost o.f uti 'shing) iA lieu of tl~ publish r assuming this cost as is the no al

practice) any ptof'":$ or- royaL.. ; ~S up to th2 am ,lnt of such cost snall be creo'ted to t,e Grtnt.

(4) The Grar.te., is. ''l'mit~ed to secur~ copyriaht to ail)' pub­ication pro~Jced or c~nposed under the Grant. Provided, the Grantee agr~es

to and doe5 h~reby grant to the Government d royalty-free~ non-exclusive and irrevocable license t'II'Oughout the ,;/otld to use, duplicate, disclose, or dispose of such publica.tiL'ns in any manner and for any purpose and to permit o'hers to do 50.

\

,

.... :,..

....- - ....~ ...

(2) ProcureTcnts III ertake ar;d ""hich c./Cilable al d normally sold or ex e, 'e; during the perio; of of Paragraoh 1 above, provided that the origin of such materials and the co po ent parts thereof is in AID Geographic Code 935.

n. Pro cure en t

(1) Except advanc.~ by the Grant Officer, below, all mut'rials~, attributed to this Grant and which wi 11 dollars shall be p'Jrchased in a d shi addition, fot'. any U.S. Grantee shall and producti on requirements aoplicable supplier must execute and furnish Agreement \'lith the Agency for

(3) -he Grantee shall extent pass ib1e for any procuremen by ·the Grn ,tee approv~d b;y ~he Gra~t a cost-plus-a-percentage of cost

0 f 5J:!P.-!_'--'-"-_._-"--'-----'-~ _

as may be spcci~ically approved or directed in or as r vided in Ram r ohs (2)

s')'Pplie5 n s vic.s thE' ::05"$ )f vlhich be finalced with United Strtes

ed frl)m t ~ United .tates. purchase trans.::ctirn in .xc ,55 of $2,500 the

notify the seller that i;hc item(s) liSt be of U.S. a ld comply wi th the cOIl.Jonentry 1imitations and oth~:r

to supplier: under AID R.~ul tion 1, and that the Fa -m AfD-282 liSt! pliers Certificate lind

Inter 1 '\tion2,1 Devel iJl,enL II

in th~: ounti~'y in \'ihir:h ii Jctivity i~ [l"e less tt1cr ,2,50. and a\~t: or tcrials

on the lOtal llir':et) \"';(;11 are to be tr~ Grant) arr.> ("_.pt from the condit'iol1s

a free 't,orld C(I,lntry as descl'ibed

(lb: in co petition to the maxinum tc be fi nane,: horelmder.

~...;thout 'Con ider"",i.tf v,' 'II'''' th-n Olk'S urce must be Officer. In no event will any procurement be

. is.

taing (regularly cons lined

and supplies

___=.c..

an (3) al'~ to be

In

source

Procurement

on

.. .~ .'

o. Subordinate Agree~~nts (Oct. 1974)

The placement of subordinat~ ~greements (e.g., leases, options, etc.), grants, or contracts with other organizations, firms or institutions and the provisions of such subordi~ate agreements ~re subject to prior written cons~nt of the Grant Officer if they will be funded hereunder. In no (!vent shali any such sub9rainate agreerr~nt, grant, or contract be on a cost-plus-a-percentage-of-cDst basis. Subordinate contractors (includingsuppiiers) shall be select~d on a cQnpetitive basis to the maximum practi­cable extent consistent Wi~1 the obligations and requirements of thisGrant.'

PAYMENT

" .

Attachment C

PROVISION

Periodic Grant Disbursement

Each month~ or at less frequent inter.vals as agreed upon in advance, Grantee will submit to the Office of Financial Management, FM/CSD,AID, Washington, D.C. 20523 Voucher Form SF 1034 (original) and SF 1034-A, three copies, each voucher identified by the appropriate grant number, in the amount of estimated cash needs for the following month. The voucher shall be supported by an original and two copiesof a report rendered as follows:

Amount of Grant $xxx Expended to date $xxx Expended this period (by line

item as set forth in budget) 1. $xxx 2. $xxx 3. $xxx etc.

TOTAL THIS PERIOD $xxx Advances outstanding to svbgrantees (if any) $xxx

Anticipated expenditures next month (dates) $xxx

Cash received to date $xxx Cash required next month $xxx

The report shall include a certification as follows:

"Th'e undersigned hereby certifies: (1) that the above represents the best estimates of funds needed for expenditures to be incurred over the period described, (2) that appropriate refund or credit to th8 grant will be made in the event funds are not expended, (3) that approp~iate refund will be made in the event of disallowance in accordance with the terms of th is grant and (4) tha t any i nteres t accrued on the funds made available herein will be refunded to AID.

BY_==-__.::::==-__

TITLE DATE ----:----~=-- ---:":::::==

DEPARTMENT OF STATE AGENCY FOR INTERNATIONAL DEVELOPMEN1

WASHINGTON. D.C. Z05Z3

Professor R. H. Regamey International Association of Biological Standardization Institut d'Hygiene No. 1122 Geneva, Switzerland

APR 5 1876Subject: Amendmen trIo. 1 to Gran tCERTIFIED .1 TRUE Copy -r:HI~

No. AID/ta-G-1244I qtJ)D DiY OF~\ \0.~ ----J C PIOIT Nc. 931-11-999-003-73

BY '£ IQJ:l,.\,.-'C'A.~+1J 3168641

Dear Prof. Regamey: )\;1

Pursuant to the authority contained in the Foreign Assistance Act of

1961, as amended, and Executive Order No. 11223, the subject grant is

hereby amended to extend time period of this Grant and to modify the terms

and conditions set forth in the basic Grant Letter and Attachment A

entitled IIProgram Description," as fo110\'ls:

A. Basic Grant Letter

1. Paragraoh 1 - Add the following:

"In addition to the above, the Grantee shall conduct two (2)

Symposiums to be held between October 3, 1976 and October 13, 1976.

Program outline will be submitted to TA/AGR, Dr. Konnerup, by the Grantee.

Upon Dr. Konnerup's receipt of the program outline, Amendment No.2

to this Grant will be issued to incorporate the details of such

program.

2. Paraqraoh 2 - Delete "ft.pril 1, 1976 11 and in lieu thereof insert

IIJune 30, 1977."

B. Attach~ent A - Proaram Descriotion

1. Paraaraph A - Puroose of Grant - Add the following:

liThe Grantee will conduct t'dO (2) Symposiums: 1) on "Foot and

Mouth Disease Vaccine ll to be held October 3, 1976 through October. 7, 1976

.// ..,/ I "

2

in lyon, France and 2) on IIFreeze Drying of Biological Products ll to be

held October 10, 1976 through October 13, 1976 in Washington, D.C.

The funds are available for the oeriod set forth in this amendment

without additional costs to A. I.D. II

2. Paragraph C - Imolementation - Delete in its entirety and in lieu

thereof insert the following:

"C. Implementation

To achieve all the objectives of this Grant, the Grantee

shall carry out the following activities with funds provided by this Grant:

a. Issue invitation to the following participant for the

conference participation:

Or. Alexander Kahn Israel Institute for Biological Research Ness-Ziona, Tel-Aviv

b. Issue invitation to biological and veterinary scientists

from Latin America, Africa, and Southeast Asia for participation in the

two (2) symposiums. A list of these participants 'dill be submitted to

TA/AGR, Or. Konnerup, by the Grantee upon receiot 01 this amendment. Upon

Dr. Konnerup's receipt of names Amendment No.2 to this Grant will be issued

to incorporate these names.

c. Provide travel and per diem for Dr. Alexander Kohn and

other particioants who will become known, as indicated above. Provide

published proceedings for one (1) conference and t'dO (2) symposiur.ls.

d. Hola one (1) Conference and t'.',o (2) Symoosiums in accordance

with the orogram AttachmentA-l hereto entitled 14th CONGRESS, ISLE OF 1·1Ail (UK)

September 21-26, 1975. The program for the t'f/O (2) symposiums 'dill be

3

submitted to TA/AGR, Dr. Konnerup, by the Grantee. Upon receipt of the

program, Amendment No.2 to the Grant will be issued to incorporate the

details of such program.

3. Paragraoh 0, Reoorts - Delete in its entirety and in lieu thereof

insert the following:

"0. Reoorts

Grantee will provide, no later than six months after completion

of the one (1) conference and two (2) symposiums, fifty cooies of each

proceeding in the English language according to the standard format of the

lABS 14th Congress Proceedings, Freeze Drying of Biological Products

Proceedings, and Foot and Mouth Disease Vaccine Proceedings. In addition,

Gr~ntee will provide copies of TA/AGR selected oapers of the one (1)

conference and b/o (2) symposiums. The reoorts \'/ill be submitted to the

TA/AGR technical sDecialist stated beloH:

Dr. Nels Konneruo, TA/AGRDeoartment of State Agency for International DevelopmentWashington, D.C. 20523"

4. Paraqraoh E, 8udaet - Delete in its entir:ty and in lieu thereof

insert the following:

liE. Budget

The funds provided herein shall be used to finance the

fa 11 owi ng items:

4

FR: 9/1/76Items TO: 3/6/77

1. Travel &Per Diem $ 9,900

2. Publication EXDenses 3,500

3. Administrative Costs for two Symposiums 3,800

4. Other Direct Costs 200

Gl'and Total $17,500

The Grantee may not exceed the total amount of the budget. Adjustment

among line items are unrestricted. 1t

All other terms and conditions of this Grant remain unchanged.

If you are in agreement with this Letter Amendment, please so acknowledge

your agreement by signing and

Technical Assistance Branch Central Ooerations Division Office of Contract Management

ATTACHi1Er·'T:

A-1 14th CONGRESS, 'Isle of Man (UK), Sept. 21-26, 1975

ACKNQ\oJLEOGECl :

INTERNATIQ:!.t.L ASSOCIATIml OF SIOLOriICAL ST.~:lD,~R8IZATION

BY: ----------------Prof. R. H. REG;' MEYTITLE:

----mrc:-r.7TT1~";::"";"7::_=_"r::__-----INS J II U J iJ r. I >;,.:.;11:.

returning the ori .

Sincerely y

I ~ --':/2..,,--,)• ~·~eu!:.k"1""1.--....~~_~

Cr3nt Offi cer

(7) cODies.

DATE: GENE'IE.-----~-----------

/I'

Lll Ulll '! ;+.) ~G

ATTACHl;:ENT ~-l

1,75

Vaccin~ .. :,..., ~ .. ··~.·t '.·.·on-D .... -.:........_'•. :'"'"1'. -,.. I ... --_ ....... .::..~ .. _._. ---_.• ;.::..;;...;•...;-:...=-.-:.. ~: '::­

HUr.I.ii1 V~ti?rh!:; ..---- ----- .. -.-==------_ .... _.- ------_. V 1.0 BJ·-:c ...;r:_._----"

1. 1 ~··r:· :,.: ~ la H 2.0 B~ct.:ria l.2 E=.::i:,t:l~3-S·.J~I~:.1

2.1 1':;?::vi~ 1. 3 ~t ~·,::~f::~\:L'~t:l!.:;-.J.: :~·t ';:~~·.:::::s:; 2.2 Chol·.:r.: CPh~-vr'("')·.11•• -.. •...... _. S·,·····)t ', ....

2.3 Coli 1.4 I,:i':'~'i;,)-$i:~cp 2.4 Shi~el!.J

2.5 Tuld!"~~::1i:L V 2.0 2.6 Pe:-t-';53i5 2.1 .\'.'i.1:' r.~c~?h:ll.::::..ditis 2.7 Bee (5~iection res~rved) 2.2 ~~~~~stl~ Dise~3e

2.3 r~~···:ti.olJs BronchLtlfiH 3. a Tox-:>i.:; 2.4 Inre~tjous L3:-y~~otr~chcLci~

3.1 Dipht~eria 2.5 rnf~~tiou~ ~ursal Disc~~~ 3.2 Tetant.:5 2 . 6 r~".: 1?:) :.: 3.3 Chul~:-:! 2.7 rcli;,~ Pa:11eu~o?.:!~i.;.

2.8 ~.1':>i ...·c; H 4.0 Vinls 2.9 Tr~I~·::-:i5sib1.e C:1str0('nt~:-itis ­

4.1 Adcr.o $':..·in~

4.2 RUOl~ll.:l Z.lO Cali ~~~;ir~s (SC0U~5)

4.3 !r.tlu.::::::~ 2.lt 2~c~~h~1~:~~:Cl~di:i5-~L=~s in ~l~ ..t..~ :.::>

~

4.5 r~t!~ (;~1~c~i0n r~3~r~·~~)

Sessi.on 1

us i:!; Spi:'<l:: ~·I. SAl.Sill:

1.3 Viral V<lc.;:i~.l::':'n ':l:: tile nO:1-?.:lrer.:~r.;l route: pre-re~ui3i~~ :a~tors and ch<lra~t~ristics of i~cur.e

re5p-:>ns~ P. L. OS2A

1.4 V.:1cci,=1':'ti.Oi'. di9~.lSeS in

C'" ::;l~ r.~1i'.-.".'!!"~:'lti·r~1

ct~ ~et:e~i::3ry ~i~ld

route on '/iru.:;

loS Report on ",'jia=1 ?~J~U~~S st~n '~:jlz.1tion cv:~it­

teE; (Ch.1ir:::·1~: ~'!:-. :: . c. H\J 1.s ~ ) B. R. oU~·:::::ST:'~

( /'/

2

Sessi.on 2

2.1 I~uni~~tion by 1eroso1 of ~ntl=.eni~~ceoeeal 110­

philiz~d vacci.n~

2.2 Str.:!;>toeoc::a1 vacc ine .:lc::linis t'er(:d ~y 'nasoph.:lr­yngeal S?:'..l;:

2.3 ASS3Y of n~n-?3rcn~er31 vJ.ccinJ.tiQ~ =£..linst brucella C. PILE!

2.4 Ef:cetiv~n~s~ oc Or.:l~~i ac~i~i5te:,~J

Dertu3sis VJc~i~~ in ciee H. HOF

2.5 E:q'lf:rienl.·"::; ·..·(c11 or..lll·: :\cl:,:,:l.:~tst'.:r•.:J ~.:::..::..!~:.~:...~:_:

Dct'tuc;:;is "::('I:tnCS in '='.:.:~d~s

3.2 Potency t~~tin~ of in~~tlva~~d c:,al v3e~in~s ~~r

hur...an US£! I. J00

3.3 Fielj trlil '.... i::. orCil ty:,;:'oi:! ·...JCCi:1C

3.4 Vacci~~ti~~ as~in~t :J?~oij

uated ora! v~eci~e

3.5 Aerosol SCG used as i==unoth~r~rJ of patients ~ith , •• T "-,\" ,.lung cancer R. H. ,,;·••• ;1 . .•"\" ,

4.1 1::.:1uni:::, s::u::ii-as in e.:l.h'cs ·:a::cin.ltd '..'l.t!1 a cultivale~t li~c :~s~ir2:c:y va:cine co=?O~~j

of IB~ ~ar2!nf~~e~~~ 3 and b~vinc ~denoviru5

ty?e 3

4.2 Coc?ar~J ef~i~i~n:y ~l:h a ~ill~d. n livi~~ v~~~{~c

and a:1 a:1c!;,=~i..: [r.;.l~..:tiua in t~~ i::::;:~~Lz,1:'i.O,~ ,,: the ~ouse, by ~r~l ~an~l

4.:3 Liv~ .:tCcn:j~=eJ p.:!=L1i~:!l,;c:l~n ·.':l~ci~-=: 5cu:iit'.3 in f('cr~ts

4.4 Studies in f..:t'rd5 \"'ic:h liv·~ ~tten:l:ltd influ'-.n;;a virus A. 0::L:::'!

------

_..- ..

Pro~le~s to ~on-,a~e~~cr~l ad=inL5~r~tio~ of ~{ral

vaccin~~ •... 1::11 p;?~ti ..:ul ..H' rcfet"';':1~~ co rubetl,1

3'~

tht" d r i:';'" in·: ','.~~";:

5.2 Oral i::t7.uni:.·lti:-n .:l;3inSt no:·:: in the d rb~:in~ ::<1te:r

5.1

·......--....

r. :·~:::: ..\S =' E

5.5 StU:!~C5 C:1 ':.: •. :-:!:~ 1~iC':'. :! >linst :·!arc;:'s .:!i;:..'.-~~(;

the or<11 r~'~:'~

5.~ :\rplt\:t-'~::'.;f'\ -:: ~\:-~ :::::,,~:.~y hcrpcs\"ir~c; ~:.l:'=~:·.·::

tn.:? .~.er\..t!:~:~:"; :'"v~:~~ for t;,c pre\:t:::ltio~·. (.~ :.:..::~ :.. ' ~

dis~.:!5~

"'. CA; .'..::. )

5.9 I~tr~~~3~1 v~cc!~~ti=~ of c~~tle a~ai~5t !~~ ~n~

Pl): . fielc .:l:::! l.:.b.:-.r.lt\"r;.· u".-;~n.. ,:ion5 1:1 c..d:-::, beef =:1d n~on~tal c~lf ?o?~l~tiC'r.s J. D. TO::::l

5.10 I::'~:~:1e re':~O;15= to o!':lll:. <!d~:'nis:.:.':~cl

and coro:1:l~ir~s v3c:i:1e

S~5S.i(;~ 6

6.1 Evaluation oE vi:~s strai~3 ~scj in li~c infl~~~:a

vaccines

6.2

6.3

6.4

6 . 5 T: I'; '''; :; ..:: 0 i 1 i : ~ ..!: t ~ :1~. ~ ~ .:: ~: i ~: : 1'..;.: ~ :: -~ . .:l .: '.: 1. ~ :: ( t J - 1) (I::) in :::~~L

sturlics

Us"! of li'le Cl~~':::'llFlt.::d i:lfl'I'~~z.l ";"CCLII.:! in nori:"..ll .1~.! ;1;:;::::·::::.t i.:: .:!·j'Jl t5

tiv~ ~tt~nc~:~d r=~~i~:l~~n~~ in ~~n

6. a ll' , • .• , 1 '., ~ ,.., '~1,' - ":"':1 .:' 1: ....'t'\,)t.,;U..:.t:1IJ" \l:1\~ C~C .. ~~l\:&3 cn.......l_ .0_, __ ... .. ~... ' V~ _.L.t;;

LeC:O=Jlt'1.u.~t\.. .. :t/:". ....... l.;:~~n':l ... ,/-I:" , ·:acc l~._I '..

I.,'J ~:,Hur.11 C'ha~' ~~:; ,1f s_:, i, ·.:ts va·.:l'i:-t.1tio;1 :.:ith V:-,r. lOS 5tr.:lLn ~ >:.,> :~fl~(·:!::, ·:.:Jccin~ ~:l n::Jh~c:1ti~l c OiillJUn i to'l

Clinic.ll :r~~:~ ~~:h i~~:~nasallJ ~~~ini~ter~J '.··.."'1...... 105 strain &~~~ i~f!~~n!~ vacci~~ In V~~~~tc~rs

(,.: 1 C,':lp<lri.::on r.: .. ::.::n·:,:,,; '.If intr.1:~:~ ,: "',,'\.j,.~:.i\:; ..... ith reco;::;'lt1 "nc \':~:L 2/)5 saaio 11'.: ::~(.'~~'::':'d, 1:' ­

"

s~::: 3 :":1 7-_.-._-­.. I I •• ':\'".!.~:l i:~:,·.:t:':'~~;~ ::-::-":-:=hlti~ '.·(1cci:1.~:

or J~rj~~J 7i~~~!

7.2 'fite pro?~s::ci in:.;:rn:1Cional stCi~d,:!rd CIt i::f~ctlvu~ bronchiti~ ~~cci~~ (live)

7.3 Stu,~ii.:s on v.:!,:ci".:l::ioJn a;ain.sr: la.::-:';-:~:);:::':~b~ic~s ::: the drin;';'b~ ·..·~:.:r

7.4 • - I. .... :.:11 ~ r:­

7.5 roE~ct[~~s burs31 ~!s~~~e vacci~e - S0~~ re~~r;';'5 :)n prochlct 10:'1 c.::d ':C:1:: r.::.!.

7.6 StnndJ.r:3 ~cr ':,1,:'::i:'lcs cJ~~:!in.:;t i:-::=..::: l"'':s '~r:..:.ll dis~,~sc:

LL ...... ·.'i I"::S

E. C.

D. ','.I~.C,':'.:.:.,-".,'

D. g,

t.l. c. :.::-' l 'F"

A. Si::[~'~':::;LS

Co. vr£LEZ

L. ::;\i\Jr:L..r.1

DEP r T .. 1-.. '.':. • :, I :.

AGENCY FeR I 'jOE i',

WASH :-lGT N. _ '- • .~j TA/PPU OCT 15 1976

Nov lli 2 S6 PH '76 Professor R. H. RegameyInternational Association of Biolooical Standardization Institut d'Hygiene ~ CH-1211 Geneva 4, Switzerland

Subject: Amendment No. 2 to Grant No. AID/ta-G-1244 PIOIT No. 931-11-999-003-73 3168641

Dear Professor Regamey:

Pursuant to the authority contained in t ~ Foreign Assistance Act of 1961, as amended, and Executive Ord- ~o. 11223, the subject grant is hereby further amended to ir.ccr'Dorate the attached program description which was provided 70r i ~mendment 1 of this grant. Except as expressly amended he" ~'n ~~e grant remains in full force and ~ffect in accordance wit its ~erms.

Please sign the original and eight cODies of this Amendment to acknowledge your understanding of the conditions under which,this Amendment has been made.

Please return the original and seven (7) eooies of the grant amendment to the Grant Officer.

• . e Grant O"ricer Technical .55' stance Branch Central O~2r: .~ons Division Office of·Con.ra~t Managem~nt

Attachment: as stated

ACKNO!'lL.EDGED:

~

rITLE:

I

INTERNATIONAL ASSOCIATION

BY:

D,a, TE: -_. _._-------

I "y'

Program Description

A. Purpose of Grant

The purpose of this Grant is to provide support for two cor~~r- C~S the first, "International Symposium of Foot and ~'outh Di'3t::~l. "_ ttie second, '"International Symposium on Freeze Drying 0'- eiolo;~ical

P-roducts", for the purpose: 1) to di sseminate the knm'!', edg tl .; ~s accumulated in these research fields 2) to present sc1~ntific di~sertations on new research activities 3) to outline plans for future research trends in these f.ields and 4) to prepare and di$tribute tne Proceedings. The first Symposium on Foot and ~louth DLe' e I'li il be held in Lyon, France under the auspices of the Internatio 1 Association of Biological Standardization, October 5-8, 1(76, nd the second, Symposium on Freeze Drying of Biological Products. ~Jill be held in Washington, D.C. Also under auspices of the Internatio al Association of Biological Standardization October 10-13, 1976.

B. Specific Objectives

The specific objectives of the Grant are as follows: . .

1. To evaluate the state of the scientific achievments and r~sults of research and to indicate areas where these development ay beI

applied.

2. To make recommendations on promising research development that should be pursued and to establish expanded communications be-vee1 researchers in these fields.

3. To analyze new and innovative equipment and techniques that contribute to more effectively useable products in the field.

c. Imp1.ementati on

To achieve the above obje~tives the Grantee shall carry out the following activities with funds provided by this Grant:

1. Issue invitations to biological and veterinary scientists from the following LDCs and institutions:

For the Foot and Mouth Disease Symposium:

Partici pants:

Dr. A. Sy11a, Central Veterinary Laboratory-Bamako, Mali

I ,

.,,-

Dr. Ceasar Labo, Instituto Co1ombiana Agropecu:'i.lr;o, GO~ot3, ColOl::t~ Or. Alex Kahn, Veterinary institute, Beef, Dag,~. rsr~el

Dr. Sam CheJl1a, Veterinary Department, Nairobi, ::enya.

For the Freeze Drying of Biological Products S~pu~,;urn:

Participants: Dr. r·laurice Kalunda, East African Veterinary Org3nization,

Maguga, Kenya Dr. A. Sylla, Cel~tr;;\l Veterinary Laboratory, ~a1T!ako, ~~ali Dr. Alex Kahn, Veterinary Institute, Beef, DaGon, Israel Dr. Ceasar Labo, Instituto Colombiano Agropecurario, Bogota, Colombia

2. Provide travel and per diem for participants indicated and Dublishes conferences proceedings.

3. Hold Symposiums as listed above.