Slides_Product_Dr Chen_100320_2010_Road+Show_E (Rev 03).pptx

7/28/2019 Slides_Product_Dr Chen_100320_2010_Road+Show_E (Rev 03).pptx

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Preview : Yung KienGanoderma 2

Deng-Hai Chen

Shuang Hor Group BTRI


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The Motive & Objective of

Research & Development

Motive : Meeting customer expectationto reduce the amount of consumption.

How to reduce the amount of

consumption and yet maintain theefficacy?

The need for compositional realignment.

The only approach : To develop a product

with extremely high content of theeffective constituent - triterpenoids


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Effective Constituents of Lingzhi

Species Type Ganoderma tsugae Ganoderma lucidum

Triterpenoids Ganoderic acids, ganoderiol,

ganodone, and ganoaldehyde

Lucidenic acids, lucideriol, lucidon

and lucialdehyde.

Polysaccharides (peptides) Macro molecular polysaccharides

(peptides), hetero glucan, glucan

peptides, hetero glucan peptides

Macro molecular polysaccharides

(peptides), hetero glucan, glucan

peptides, hetero glucan peptides

Plant Steroids Ergosterol-moiety sterols and

lanosterol-moiety sterols.

Ergosterol-moiety sterols and

lanosterol-moiety sterols.

Nucleotides Uridine, guanine, and adenosine. Uridine, guanine and adenosine.

Polypeptides Micro molecular protein LZ-8 Micro molecular protein LZ-8


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Uniqueness of the Effective Constituents

Types of Effective

Constituents

Num

ber

Uniqueness Explanation

Triterpenoid ganoderic

(lucidenic) acids

~200 Yes Only found in ganoderma

Polysaccharides (peptides) >100 Nil Also found in shiitake mushroom,needle mushroom, etc.

Plant Sterols >20 Nil Also found in mushroom and other

plants.

Nucleotides ~5 Nil Also found in mushrooms and other

vegetables.

Polypeptides ~10 Nil Also found in shiitake mushroom and

needle mushroom


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Pharmacological Actions of Triterpenoid

Ganoderic (Lucidenic) Acids

Type of Effective

constituents

Pharmacological Actions

Triterpenoid Ganoderic

(Lucideric) Acids

Immune modulation, liver protection, anti-free

radicals (delay ageing), improves the condition ofallergic physical constitution, regulates blood

sugar, subdues tumour growth (anti-cancer),

reduces blood lipids, bring down blood pressure,

inhibits (HIV) viruses growth, anti-inflammation,

helps prevent prostate enlargement, enhances

learning ability, and improves memory.


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The key determinants are ganoderic (lucideric) acids, to

be followed by polysaccharides (peptides) and then

neucleotides.

Both Japan Health Food Authorization (JHFA) andTaiwan Functional Food GMP take ganoderic (lucideric

acids as the determining benchmark.

The low content and difficulty in isolating of ganoderic

(lucideric) acids explain why research works on themwas much lesser than on polysaccharides.

Differentiating the Good Quality

Lingzhi from Others


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Lin Zhi Bingof Peking University Health Science Centre, China

Hattori Masao of Japan.

Xiao Ming Xiof National Yang Ming University, Taiwan

Su Qing Hua of Taipei Medical University. Lin Yun Lian of National Research Institute of Chinese Medicine

Taiwan.

Lin Shu Pin of National Taiwan University, College of Medicine,

Taiwan

Yan Guo Qin of National Chung Hsing University, Taiwan

Prominent Lingzhi Researches


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It all began in the 1970s. Mostly on the research of

polysaccharides, as they were much easier to isolate

and featured a high content.

The research on triterpenoids, such as ganoderic(lucideric) acides, began only in the 1980s, because

they are trace components and difficult to isolate.

Due to the success in artificial cultivation, more than 20

types of triterpenoids, including ganoderic and lucidericacids, have since then been discovered.

The History of Modern Research Works

on Ganoderma Effective Constituents


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By the 2000s, the gap in the number of researcharticles between triterpenoids and polysaccharides hasnarrowed substantially

Towards the end of 2005 and beyond, there has beenan increasingly bigger number of research papers ontriterpenoids, mostly pertaining to anti-cancerexperiments.

It has been revealed that triterpenoids exhibit direct

pharmacological actions, while those of polysaccharideare mostly indirect.

Polysaccharides and Triterpenoids


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Polysaccharides: Diversity is essential, but the

consumption amount needs not to be high

(higher than 3g), as the pharmacological action

are indirect.

Triterpenoids: Diversity is also essential, but fo

particular individuals, high consumption amounts

are needed in order to show efficacy.

The Effective Constituents of Lingzhi


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The Processing Involved in Developing a

Natural Drug

An efficacious

natural substancesWhat sort of efficacy?

Development of effective

Constituents/crude drug

What are the effective

Constituents?


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Lovastatin : A hypolipidemic drug for reducing blood lipids,

purified from red yeast rice (Monascus app).

Silymarin : A hapatinica drug for liver protection, purified from the

seed of milk thistle (Silybum marianum).

Colchicine : A hyperuricemia drug for the treatment of gout,

purified from the bulb of autumn crocus (Colchicum antumnale).

Taxol : An anti-cancer drug for subduing cancer growth, purified

from the bark of ground hemlock (Taxus brevifolia).

To achieve high potency, it is essential to purify the effectivecomponents from raw materials.

Some Notable Natural Drugs


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Developing medicinal drugs that are free from side effects.

Extraction from natural substances stands the greatest chance oachieving this objective.

Most of the medicine available today are known to exhibit side

effects. Ganoderma : Contains ganoderic (lucideric) acids, making it the

most potential to be developed into efficacious healthcareproducts that are safe for long-term consumption.

Shuang Hor is the only enterprise having the worlds most

resourceful background to develop ganoderma triterpenoids asthe natural drugs

The Ultimate Objective of Western

Medicines


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The New Milestone of Ganoderma Bio-

tecnology: Purification & Mass-production

Purification is different from Extraction & Concentration

Extraction/

concentration Purification

Raw Ganoderma (the content of 9Ganoderic acids: ~0.2%)

Triterpenoids

100%triterpenoids(the content of 9ganoderic acidsexceeds 50%)

Ganodermaproducts (the

content of 9ganoderic(lucideric) acids:2~9%)


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Progress Made in Purification Techniques

Mass production of Ganoderma triterpenoidsbecame feasible.

In 2008, the content of 9 types of ganoderic (lucideric)acids was purified to exceeding 50%.

In 2009, pilot-production became a success withtechnology transfer to Yung Kien Plant. Shuang Hor is the worlds first enterprise to embark

on the mass-production of Ganoderma triterpenoids. The first setp to bio-tech pharmaceutical production :

Purification & mass-production. The purification facilities and techniquest are kept as

a top trade secret.


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Patent Pending for Yung Kien Ganoderma 2

The patent for the production process is nowunder application. Patent application numbersare 98102308 and PI20090273 for Taiwan &

Malaysia respectively GANODERMA EXTRACT WITH HIGH

AMOUNTS OF GANODERIC (LUCIDERIC)ACIDS AND METHOD FOR PRODUCING THESAME


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Yung Kien Ganoderma 2 and its Raw

Ingredient

YK-01 only, but should be carefully selected.

Only the fruiting bodies cultured by computerizedhi-tech greenhouse, and harvested with

professional screening. Only those with high amounts of ganoderic acids

are accepted for production.


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Yung Kien Ganoderma 2 and its Process

With the inclusion of purified YK-1 triterpenoids, itscontent of 9 types of ganoderic acids has increased to12% and above.

Retention of the effective constituents of Yung KienGanoderma.

Purification -> Mixing with Yung Kien Ganoderma ->Freeze Drying (Lyophilization) -> Filling

Retention of the effective constituents and safety ofYung Kien Ganoderma, giving an upgraded productwith rich content of triterpenoids.


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Yung Kien Ganoderma 2

An innovation ofGanoderma productby the combination ofagricultural bio-technology and bio-chemistry purificationtechniques.


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9 Ganoderic Acids (A, B, C, etc) and Their

Average Contents

6 capsules reduced to 1, which means a 6-fold increase of thecontent of the 9 ganoderic acids.

Yung KienGanoderma

Yung KienGanoderma 2

2% 12%


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Who Can Benefit From Yung Kien

Ganoderma 2

People who are unable to consume large doses(more than 20 capsules a day) and in need of largeamounts of ganoderic acids.

Patients of autoimmune diseases: asthma, allergies,lupus erythematosus, rheumatoid arthritis,myasthenia gravis, psoriasis, etc.

People who suffer viral hepatitis and liver fibrosis.

People who underwent organ transplantation.


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Testimonial : Psoriasis (a disorder

characterised by dry, scaly skin)


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Psoriasis (a disorder characterised by dry,

scaly skin)

Causative factors : Auto-antibodies produced by white bloodcells attack the outer layer of the skin. It is an auto-immunedisease.

Conventional treatment: The use of powerful steroids.

Symptoms were first observed in 1996 and the cause wassuccessfully diagnosed only 3 years later (1999).

Underwent treatment during 2000-2002, involving oral intakeand topical application of steroid formulations. Apart fromgiving rise to side effect such as moon face, joint pain,

lethargy, and pain while urinating, the treatment was noteffective.


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Psoriasis (a disorder characterised by dry,

scaly skin) with Ganoderma

In 2002, began the consumption of Botanical Lingzhi (40% lingzhi + 60%pollen)

With the consumption gradually increased from the initial 10 capsules to 30capsules a day, improvement result was observed 3 month later. Followingthe disappearance of the silvery scales, the consumption was reduced to

10 capsules a day. In March 2006, the condition recurred due to physical exhaustion.

Switched to the consumption of Yung Kien Ganoderma, 20 capsules a dayfor 50 days.

Experienced strong vertigo reaction and become bedridden for 2 weeks.

Causative factor of the onset :Sensitivity to low temperature.

Upon recovery, the patient has been able to join in the oversea tour to Mt.Fuji, Japan.

Wh C B fi f Y Ki


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Who Can Benefit from Yung Kien

Ganoderma 2

An adjuvant for AIDS patients undergoing medication

An adjuvant for patients of cancerous diseases:Leukemia, liver cancer, prostate cancer, colon cancer

For other cancerous diseases, the consumption ofYung Kien Ganoderma can be reduced.

Both Yung Kien Ganoderma and Yung KienGanoderma 2 can be taken together to get asynergistic healing effect.

T ti Li Ci h i ith


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Testimony : Liver Cirrhosis with

Complication of Liver Tumour

Suffered from liver fibrosis in 1999at age 34, caused by hepatitis C.

In 2003, began the consumption ofYung Kien Ganoderma, 12capsules a day. Reduced to 4

capsules a day 3 months later,thinking that full recovery has beenachieved.

Experienced recurrence in 2005,complicated with liver tumour.Began consuming 30 capsules of

Yung Kien Ganoderma a day for 7months.

T ti Li Ci h i ith


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Testimony : Liver Cirrhosis with

Complication of Liver Tumour (contd)

By March 2007, liver functions restored normal. Thetumour disappeared and fibrosis was gone. HepatitisC virus still detected. Continued with the consumptionof 20 capsules a day.

By December 2007, hepatitis C virus tested negative,with the body producing the needed antibodies.

Attributing factors : 1) Had faith in Shuang Hor andGanoderma. 2) Regained optimal health through

long-term consumption in large doses (30 capsules aday).

Y Ki G d d Y Ki


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Yung Kien Ganoderma and Yung Kien

Ganoderma 2

Yung Kien Ganoderma 2 is for people with specialneeds, while Yung Kien Ganoderma is for ordinarypeople.

Yung Kien Ganoderma is a Health Food, hence canbe consumed by everybody

For the purpose of everyday health maintenance,Yung Kien Ganoderma is good enough.


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Application of Yung Kien Ganoderma 2

Health FoodYung Kien Ganoderma 2

21st C t th C t f G d


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21st Century, the Century of Ganoderma

Bio-technology

Patent owners of core technologies are destined tobe the market leaders.

Different effective constituents inherently cater todifferent targeted health-care attributes.

On-going development of newer alternative productsto give similar efficacy at smaller doses.

Ganoderma triterpenoids show the most numerousefficacies, thus posses the greatest potential tobecome medicines without any side effects.

Documents

Slides_Product_Dr Chen_100320_2010_Road+Show_E (Rev 03).pptx