SKVen Technologies Pvt.Ltd.

End-to-end solution right from development to commercialization of APIs & Intermediates

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VISION

To be a leading development, delivery and supply partner

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MISSION

To provide our customers with the best solutions in an entire pharmaceutical value chain with customized services and solutions for starting materials, intermediates, active ingredients and finished dosage forms

Why SKVen !

▸ Development of APIs/ Advanced Intermediates (Exclusive basis for select projects)

▸ End-to-end solutions right from development of API to commercialization of

APIs/Intermediates

▸ Capabilities to develop dossiers for select line of products

▸ Intellectual Property Evaluation and Protection for the projects

▸ Regulatory Competency to comply with Regulated and Semi Regulated market

requirements

▸ Project Management teams to handle projects from inception to commercialisation

▸ Dedicated teams for tech transfer activities at clients' sites

▸ Extensive strategic relationships with several leading companies and CMOs

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Our Competencies

▸ Innovative and transformational chemistry and analytical solutions

▸ Expertise in developing novel polymorphs & non-infringing routes of synthesis

▸ Developing cost effective and novel methods of analysis

▸ Experienced teams for tech transfers at any location of client's requirement

▸ Strategic relations with several CMO/ CROs to address client specific special

requirements

▸ Global market access through own front end presence and agents spread across

both regulated and emerging markets

▸ Tie-ups with several leading logistics to ensure timely deliveries

Our Facilities

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▸ State of the art Research & Development facility spread across 15000 Sq Ft area.

▸ Multiple bays with customized hoods and equipment to handle various

reactions

▸ Dedicated analytical equipment for each category of products to ensure smooth

flow of development process

▸ All the systems and analytical setup and monitored by QMS systems

▸ Strategic partnerships with various CMO | CDMOs & CROs for certain projects

▸ Development of FDFs and Dossiers for select dosage forms and products

▸ Heck Reaction

▸ Mitsunobu Reaction

▸ Suzuki Coupling

▸ Sonogashira Coupling

▸ Asymmetric Oxidation

▸ Wittig Reaction

▸ Swern Oxidation

Our Chemistry Capabilities

▸ Asymmetric Catalytic Hydrogenation

▸ Chiral Separations

▸ High Vacuum Distillations

▸ High Temperature Reactions

▸ Hydrogenation Cryogenic Reactions

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Our Development & Analytical Capabilities

▸ Wide range of in-house Analytical R&D equipment for product development, method development and complex characterization.

▸ Regular calibration and maintenance to ensure accuracy and precision

▸ Access to advanced analytical equipment like NMR etc

• Freeze dryer• Vacuum tray dryer• Air tray dryer• Autoclave• Stability chamber

• HPLC• Gas chromatography• DSC/DTA• UV Spectrophotometer

Our equipment includes but not limited to

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S.No. Product Tech Pack Therapeutic category

1 Dapagliflozin Available Anti Diabetic

2 Ivabradine HCl Available Cardio vascular

3 Istradefylline Available Adjunctive treatment to levodopa/carbidopa

4 Pitolisant Hydrochloride Available To treat ESD in adults with narcolepsy

5 Chlorthalidone Available Cardio vascular

6 Isoproterenol HCl Available Cardio vascular

7 Chlorpromazine HCl Available CNS

8 Regadenoson Available Contrast Agent

9 Edaravone Available To treat Amyotrophic Lateral Sclerosis

10 Varenicline Tartrate Available Smoking cessation

11 Methylene Blue Available To treat methemoglobinemia

12 Eltrombopag Available Lead to thrombocytopenia

13 Prochlorperazine edisylate Available CNS

14 Eliglustat Tartrate Available Gaucher Disease type-1

15 Docosanol Available Antiviral

16 Prazosin HCl Available Ant hypertension

17 Propofol Available Anesthetic

18 Nitrofurantoin Mono Hydrate Available Antibiotic

19 Nitrofurantoin Anhydrous Available Antibiotic

20 Nitrofurantoin Macro crystals Available Antibiotic

21 Trientine HCl Available Chelating Agent

22 Clomipramine HCl Available CNS

Our API Product Portfolio

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S.No. Chemical Name of the Intermediate CAS Number Related to API

1 6-amino-1,3-diethylpyrimidine-2,4(1H,3H)-dione 41740-15-2

Istradefylline

2 6-amino-1,3-diethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione 89073-60-9

3 5,6-diamino-1,3-diethylpyrimidine-2,4(1H,3H)-dione 1785764-26-2

4 (E)-3-(3,4-dimethoxyphenyl)acrylic acid 14737-89-4

5(E)-N-(6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4- dimethoxyphenyl)acrylamide

187393-68-6

6 (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-3,7-dihydro-1H-purine-2,6-dione 155270-98-7

7 3-(4-chlorophenyl)propanoic acid 2019-34-3

Pitolisant HCl

8 3-(4-chlorophenyl)propan-1-ol 6282-88-8

9 3-(4-chlorophenyl)propyl methanesulfonate 61440-60-6

10 3-(piperidin-1-yl)propan-1-ol 104-58-5

11 Sodium 3-(piperidin-1-yl)propan-1-olate 462115-38-4

Our Intermediate Product Portfolio

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S.No. Chemical Name of the Intermediate CAS Number Related to API

12 5-bromo-2-chloro-4'-ethoxydiphenylmethane 461432-23-5

Dapagliflozin

13 (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4

14 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9

15Methyl 1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-alpha-D-glucopyranoside

714269-57-5

16(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol tetraacetate

461432-25-7

17 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one 85175-59-3

Ivabradine HCl

18 1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one 148870-57-9

19[(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2- one]

1086026-31-4

20 4-(4-chlorophenyl)-1H-benzo[d][1,2]oxazin-1-one 2224-83-1

Chlorthalidone21 3-(4-chlorophenyl)isoindolin-1-one 2224-77-3

22 2-Chloro-5-(2,3-dihydro-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 82875-49-8

Our Intermediate Product Portfolio

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S.No. Chemical Name of the Intermediate CAS Number Related to API

23 2-Chloro-3,4-dihydroxyacetophenone 99-40-1Isoproterenol

HCl241-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethan-1-one

Hydrochloride16899-81-3

251-(7,8-diamino-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-

yl)-2,2,2-trifluoroethan-1-one230615-69-7

Varenicline

Tartrate26

2,2,2-trifluoro-1-(6,7,9,10-tetrahydro-8H-6,10-methanoazepino[4,5-

g]quinoxalin-8-yl)ethan-1-one230615-70-0

27 Varenicline Free Base 249296-44-4

28(2R,3R)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-hydroxy-2-(((S)-

2-hydroxy-1-phenylethyl)amino)-1-(pyrrolidin-1-yl)propan-1-one491833-26-2

Eliglustat tartarte

29(1R,2S)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(((S)-2-hydroxy-1-

phenylethyl)amino)-3-(pyrrolidin-1-yl)propan-1-ol491833-27-3

30(1R,2S)-2-amino-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-

(pyrrolidin-1-yl)propan-1-ol491833-28-4

31 Eliglustat Free Base 491833-29-5

Our Intermediate Product Portfolio

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S.No. Chemical Name of the Intermediate CAS Number Related to API

32 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one 277299-70-4Eltrombopag

Olamine33 Eltrombopag Free Acid 496775-61-2

34(3R,4S,5R)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-

(hydroxymethyl)tetrahydrofuran-3,4-diol146-77-0

Regadenoson

35(3R,4S,5R)-2-(6-amino-2-hydrazinyl-9H-purin-9-yl)-5-

(hydroxymethyl)tetrahydrofuran-3,4-diol15763-11-8

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ethyl1-(6-amino-9-((3R,4S,5R)-3,4-dihydroxy-5-

(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-

4-carboxylate

313348-29-7

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1-(6-amino-9-((3R,4S,5R)-3,4-dihydroxy-5-

(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-

4-carboxylic acid

313348-16-2

Our Intermediate Product Portfolio

OUR PRESENCE – MARKET ACCESS

our office

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Our Partner Companies

Email us at

Reach us at

Plot 130; 2nd Floor, ALEAP Industrial Area, Gajularamaram,

Hyderabad, Telangana 500090

https://goo.gl/z3w6nw

sales@skven.com

kumar@skven.com

Thank you!