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    | 1IJzer en nierschade

    Tabel 1.Overzicht rol van ijzer bij nierschade in dierexperimentele studies

    Mechanisme Diermodel Onderzoeksresultaten Ref

    Heem-genduceerdenierschade

    HA IJzer in cortex33 33HIV-HUS model IJzer in PT

    IJzer in urine39

    Rhabdomyolyse IJzer in cortex, i jzer in PT, BDI in de nier DFO therapie GFR

    22,23,32,34

    Hemoglobine IJzer in distale nephron (ook PT )DFO inuline klaring

    24,32

    Systemischeijzerstapeling

    HH (Hepc-/-, HJV-/-) IJzer in medulla en enkele cortex tubuliIJzer in urine

    25

    HH (HFE-/-) NHI, totaal ijzer niet signi cant hoger 35Nierschade bijhematurie enprotenurie

    Spontane GS enprotenurie

    IJzerde cint dieet protenurie , glomerulosclerose ,hypertensie (p

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    2 | Capita Selecta Nefrologie | nummer 2, 2012

    Tabel 2.Overzicht rol van ijzer bij nierschade in humane studies

    Mechanisme Ziektebeeld Onderzoeksresultaten Ref Heem-genduceerdenierschade

    Intravasculairehemolyse

    IJzer in tubuli, PT en LoH, Hbur , HSur . Protenurie, hematurie, ATN 17,55,56,61,69

    PNH IJzer in nier, cortex, tubuli, PT en urineTI schade, protenurie, interstitile brose

    17,58-60,89

    HIV-HUS IJzer in PT en urine 39

    Systemischeijzerstapeling SCA IJzer in cortex, tubuli, glomeruli en urine 17,57,62Thalassemie IJzer in nier, glomeruli , tubuli (DT>PT) en inters tit iumDes errioxamine-B therapie tolerantie NAGur

    17,54,64,71

    Trans usionele ijzer-stapeling

    Toename ijzer in corticomedullair grensgebied 63

    HH IJzer in DT, LoH en glomeruli, hemosiderinurie 65Nierschade bijhematurie enprotenurie

    GN IJzer in urineDe eriprone therapie protenurie

    3,76

    Diabetes, DN IJzer in urine. UIE bij diabetespatinten is verhoogd vr het ontstaan vanprotenurieDe eriprone therapie Alb/Createn stabilisatie nier unctie (in DN)

    3,74,76

    IMPG IJzer in urineProtenurie

    108

    IgA-ne ropathie Macroscopische hematur ieATN in tubuli verstopt met RBC restenDuur van hematurie corr. met naal Scr IJzerdepositie in nier corr. met NAGur

    67,68

    CKD IJzer in PTLysosomale ijzer in PT corr. met protenurieTubulaire schade corr. met lysosomale ijzer. IJzerdepositie in nier corr. met NAGur EDTA therapie vertraging progressie nierziekte

    66,67,75

    Ne rotisch syndroom(MG en FG, MCGN)

    IJzer in urine, protenurieUIE corr. met T ur T ur corr. met protenurie

    16,73

    Alb: Albumine; ATN: Acute tubulaire necrose; corr: correleert; DN: Diabetische ne ropathie; FG: ocale glomerulone ritis; Hbur :Hemoglobinurie; HH: Hereditaire hemochromatose; HIV-HUS: HIV-geassocieerde hemolytisch uremisch syndroom; HSur : Hemosiderinurie;IMPG: Idiopatische membranoproli eratieve glomerulone ritis; MCGN: Minimal change glomerulone ritis; MG: Membraneus glomerulone ritisLoH: Loop o Henle; MH: Mechanische hemolyse; NAGur : N-acetyl-b-D-glucosaminidase in urine; PNH: Paroxysmal nachtelijke hemoglubinurie;RBC: rode bloedcel; Re : Re erenties; SCA: Sickle cell anemie; Scr: Serum creatinine; T ur : Trans errine in urine; TM: Thalassemia major

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    4 | Capita Selecta Nefrologie | nummer 2, 2012

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