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8/8/2019 Silicon Nanotechnologies for Truly Personalized Healthcare Imec 091514DL
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SILICON NANOTECHNOLOGIES FOR TRULYPERSONALIZED HEALTHCARE
RUDI CARTUYVELSSenior Vice President
Smart Systems & Energy Technologies
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2© IMEC 2014
THE HEALTHCARE CHALLENGE
12M new cancerpatients each
year
350M Living withdiabetes
17M deaths fromheart diseaseeach year
36M Living withAlzheimer
’s
132M Newbornbabies thisyear
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3© IMEC 2014
*= NON-COMMUNICABLE DISEASES ONLY. SOURCES. WHO,
WEFORUM
HEALTHCARE GLOBALLY: KEY DATA
Global Mortality Rate (56MM lives)
Other
23%
Neurology
Injury6%
Respiratory
7%
Infectious Diseases
18%Cancers
14%
CVD
30%
6.0
4.8
1.0
2.5
0.7
2.1
0.9
Cancers0.5
Diabetes
+106%
$13
Neurology
$6.3
0.5
0.3
Respiratory
CVD
2010 2030
Global Healthcare Expenditures* ($T)
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4© IMEC 2014
BETTER
HEALTHCARE
hronic disease management
PREVENTIVE
HEALTH
Healthy lifestyle
ENABLING THE NEXT HEALTHCARE
REVOLUTION
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5© IMEC 2014
MEDICALQUALITYDATA
IN
CONSUMERHANDS
ULP Form Factor Affordabl
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6© IMEC 2014
Applications
DataAnalytics
SystemsCircuits
& SensorsTechnology
IMEC’S WEARABLES R&D SCOPE
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Lowest power,
smallest & robust▸ Ultra-low power ECG &
actimetry measurement
▸ Bluetooth low energy
▸ Embedded artifact
reduction▸ Accurate rhythm analysis
▸ Activity tracking & energyexpenditure
▸ 30 days autonomy
IMEC ECG PATCH
MULTISENSOR DATA FUSION
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Actimetry Application
Motion Artifact Suppression
Daily summaries
Online Feature extraction and
activity classification
Online personalized energy
expenditure estimation
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IMEC MULTI-SENSOR MIXED-SIGNAL SOC
World Lowest Power Sensor Hub for Bio-Medical ApplicationAnalog + DSP + Algorithms = 750uW in total
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IMEC & SAMSUNG DEVELOP SIMBAND PLATFORM
▸ ECG
▸ HR, HRV
▸ Blood Pressure
▸ Skin Temperature
▸ Actimetry
Based on imec’s ULP multisensor SOC & algorithms
http://www.samsung.com/us/globalinnovation/innovation_areas/
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NEXT GENERATION ECG: FLEXIBLE PATCH
10 grams
Monitors: Heart Rate,Motion,
skin contact quality
2 days autonomy on 15 mAh flex battery
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In vivoprobes
In vitrosystems
Cyto-metryMolecular
diagnostics
IMEC’S LIFE
SCIENCES
Si nanotechnology forpersonal diagnostics
& therapy
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10 mL blood80 billion red blood cells (~4-6 um)50 million platelets (~1-2 um)50 million white blood cells (~8-20 um)1-100 Circulating tumor cells (~8-24 um)
Need: powerful, low-cost, robust cell inspection toolthat can sort through millions of cells very quickly
adapted from M. Toner 13
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Granulocyte Red Blood cellLymphocyte
IMEC CELL SORTER
In flow lensfree imaging& classification of blood cells
sorting speed up to 1000 cells/s per channel
StroboscopicTracing of cells beingsorted
In flow reconstruction of a granulocyte flowing at 1mm/s
fluidic cell sorter on chip
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16© IMEC 2014
Microfluidic silicon platform Mixers, filters, microreactors
On-chip sample preparation From drop of blood to purified and amplified DNA
On-chip selective amplification Fast amplification (9 min) Multiplex amplification (more fragments in the same reactor)
On-chip detector
Dry chemistryA complexmicrofluidic Si chip
Integration of pumps and valve
with the Silicon chip
IMEC ON-CHIP DNA/RNADETECTION
DNAseparation
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http://www.diginfo.tv/v/13-0022-r-en.php
DigInfoTV Feature: DNA testing chip delivers results in one hour, paves
way for personalized drug treatments
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18© IMEC 2014
DISPOSABLE CAPILLARY PCR CHIPSchematic
Actual die Result
L a d d e r
N e g a t i v e
c o n t r o l
P o s i t i v e
c o n t r o l
O n - c h i p
imec’s lab-on-chip PCRsystem using only capillary
forces to actuate fluids very compact PCR chip
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19© IMEC 2014
EXAMPLE CAPILLARY COMPONENTSTrigger valve Tooth pump with controlled filling
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20© IMEC 2014
PERSONAL HEALTHCARE ENABLED BYSILICON NANOTECHNOLOGY
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21© IMEC 2014
IMEC’S HEALTHCARE R&D PARTNERS
http://www.catharinaziekenhuis.nl/http://www.philips.nl/http://www.jnj.com/http://spauldingrehab.org/
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