Professor Brahm S. Srivastava, Ph.D.  Former 

*Scientist in Director Grade & Head, Microbiology Division, Central Drug Research

Institute, Lucknow

*Professor & Founder Chairman, Centre for Biotechnology, Jawaharlal Nehru University,

New Delhi

*Emeritus Scientist (C.S.I.R.), Central Drug Research Institute, Lucknow

*Lecturer, School of Basic Sciences & Humanities, Udaipur University, Udaipur

*Visiting Scientist, Centre for Vaccine Development, University of Maryland at

Baltimore, USA

*Visiting Scientist, University of Ancona, Italy

*Visiting Scientist, Pasteur Institute, Lille, France

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Academic Profile

Prof Srivastava, winner of Sir Shanti Swaroop Bhatnagar award, CSIR, graduated from

Banaras Hindu University and obtained B.Sc, M.Sc. and Ph.D degrees. He did

postdoctoral research    at the University of Brussels. He was visiting scientist at Brown

University (USA), University of Maryland (USA), Institute Pasteur Lille (France) and

University of Ancona (Italy).

He had the honour and satisfaction to start the Masters Programme in Biotechnology

at Jawaharlal University and to be the member of the Task Force of DBT on Human

Resource Development in Biotechnology. He has served on scientific and academic

bodies of DBT, ICAR, CSIR, DST, ICMR, UGC and several universities. He was member of

the INDO-US Vaccine Action Programme and of the Indian delegation to USA and China

on Biotechnology.

Academic Awards & Fellowships 

B.H.U. Prize for standing Ist in merit in M.Sc. Examination.

S.S. Bhatnagar Prize in Medical Sciences, C.S.I.R., 1984.

Dr. Nitya Anand Endowment Lecture, INSA, 1991.

Dr. Y.S. Narayana Rao Oration Award, ICMR, 1993.

Shri Om Prakash Bhasin Award for Science & Technology, 1995.

Vigyan Ratna Samman, UP Government, National Technology Day, 2002.

Fellow, The National Academy of Sciences, India.

Fellow, American Academy of Microbiology.

Sources of Research Funding

World Health Organization

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Department of Biotechnology

Indo-US Vaccine Action Programme

Indo-Italian Scientific & Technical Bilateral Cooperation

Indo French Cooperation for Promotion of Advanced Research

Department of Science & Technology

Council of Scientific & Industrial Research

Centre for Biotechnology, Jawaharlal Nehru University, New Delhi

Selected, the first Professor & Chairman of the Centre and invited to start teaching and

research in Biotechnology and to coordinate with other 5 Centres for Biotechnology in

BHU, Baroda, Pune, Madurai and Jadavpur.

 Significant Research Contribution

1. Developmental Biology and DNA repair mechanisms in cyanobacteria.

2. DNA repair in E. coli and bacteriophages . A new gene locus, rer, was identified which

facilitated repair of UV-induced damage by regulating the coordination between

repair of damage and replication . The rer gene has been incorporated on the

linkage map of E. coli.

3. Pathogenesis of cholera. Landmark discovery on demonstration of expression and

modulation of cholera toxin biosynthesis by plasmids (Nature, 1978) and adhesive

protein of V. cholerae for binding to intestinal mucosa and the concept of the

subunit vaccine in experimental cholera.

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4. Tuberculosis. Identification and development of a reliable reagent for early

diagnosis of TB, user friendly non hazardous genetic screens for antitubercular

compounds, strategies to identify genes which are important for tubercle bacilli to

survive in the host and role of mycobacterial lipase in virulence and modulation of

host immune response.

Major Research Publications

1. Singh, H.N. and Srivastava, B.S. : Studies on morphogenesis. I. Effect of inorganic

nitrogen sources on developmental morphology of Anabaena doliolum. Can.   J. 

Microbiol. 14, 1968, 1341.

2. Srivastava, B.S.: Ultraviolet induced mutations to growth factor requirement and

penicillin resistance in a blue green alga. Arch. Mikrobiol. 66, 1969, 234.

3. Srivastava, B.S. and Kumar, H.D.: Inactivation and killing of Anabaena doliolum

grown on ultraviolet irradiated culture medium. Radiation Botany 9, 1969, 291.

4. Srivastava, B.S.: Sensitivity and resistance of a blue green alga to streptomycin and

penicillin. Arch. Mikrobiol. 72, 1970, 182.

5. Srivastava, B.S.: A simple method of isolating ultraviolet resistant and sensitive

strains of a blue green alga. Phycologia (USA) 9, 1970, 205.

6. Srivastava, B.S.: Pigment variation in ultraviolet irradiated Anabaena doliolum. Arch. 

Mikrobiol. 77, 1971, 274-77.

7. Srivastava, B.S., Kumar, H.D. and Singh, H.N.: The effect of caffeine and light on

killing of Anabaena doliolum by ultraviolet radiation. Arch.  Mikrobiol.  78, 1971,

139.

8. Srivastava, B.S.: Repair of gamma ray induced damage in bacteriophage lambda.

Virology 55, 1973, 550.

9. Srivastava, B.S.: The yield of single-strand breaks in the DNA of bacteriophage

lambda irradiated extra and intracellularly with gamma rays in oxic and anoxic

conditions. Int. J. Radiat. Biol. 26, 1974, 391.

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10. Lafonteyne, J. and Srivastava, B.S. Replication and recombination dependent

maturation of phage lambda. Zeitschrift fur Physiologische Chemie. 355, 1974, 54

11. Srivastava, B.S.: Radiation sensitivity of a mutant of Escherichia coli K-12 associated

with DNA replication: Evidence for a new repair function. Molec. Gen. Genet. 143,

1976, 327.

12. Srivastava, B.S.: Irradiation and DNA breaks. Nature (Lond.) 259, 1976, 425.

13. Ahmad, M., Srivastava, B.S. and Agarwala, S.C.: Purification of bacteriophage

lambda by gel filtration. Ind. J. Expt. Biol. 15, 1977, 387.

14. Ahmad, M., Srivastava, B.S. and Agarwala, S.C. : Effect of incubation media on the

recovery of Escherichia coli K-12 heated at 52oC . J. Gen. Microbiol. 107, 1978, 37.

15. Srivastava, B.S.: The role of inducible gene rer of Escherichia coli K-12 in DNA repair

and mutagenesis. Mutation. Res. 52, 1978, 1.

16. Sinha, V.B. and Srivastava, B.S. : Plasmid induced loss of virulence in Vibrio

cholerae. Nature (Lond.) 276, 1978, 708.

17. Ahmad, M. and Srivastava, B.S: Thermal inactivation and mutagenesis of

bacteriophage lambda. Mutation Res. 73, 1980, 403.

18. Rai, R., Prasad, V and Srivastava, B.S.: Symbiotic nitrogen fixation efficiency of

mutant strains of Rhizobium growing from pH 4.5 to 7.5  J.  Agric.  Sci.  Camb. 98,

1982, 487.

19. Sinha, V.B. and Srivastava, B.S.: Suppression of pathogenecity by P and V plasmids

in Vibrio cholerae. J. Gen. Microbiol. 104, 1978, 251.

20. Bhattacharjee, J.W. and Srivastava, B.S.: Mannose-sensitive haemagglutinins in

adherence of Vibrio cholerae el tor to intestine. J. Gen. Microbiol. 107, 1978, 407.

21. Bhattacharjee, J.W. and Srivastava, B.S.: Adherence of the wild-type and mutant

strains of Vibrio cholerae to normal and immune intestinal tissue. Bull. Wld. Hlth. 

Org. 57, 1977, 123

22. Srivastava, R., Sinha, V.B. and Srivastava, B.S.: Re-evaluation of antibacterial and

antitoxin immunities in experimental cholera. Ind. J. Med. Res. 70, 1979, 368.

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23. Sinha, V.B. and Srivastava, B.S.: Attenuation of virulence by P and V plasmids in

Vibrio cholerae: strains suitable for oral immunization. Bull.  Wld. Hlth.  Org.  57,

1979, 643.

24. Srivastava, B.S., Sinha, V.B. and Srivastava, B.S.: Attenuated recombinant strains of

Vibrio cholerae for oral immunization. Bull. Wld. Hlth. Org. 57, 1979, 649.

25. Srivastava, R., Sinha, V.B. and Srivastava, B.S.: Events in the pathogenesis of

cholera: role of bacterial adherence and multiplication. J. Med. Microbiol. 13, 1980.

1.

26. Srivastava, R. and Srivastava, B.S.: Isolation of a non adhesive mutant of Vibrio

cholerae and chromosomal localization of the gene controlling mannose sensitive

adherence. J. Gen. Microbiol. 117, 1980, 275.

27. Knopf, P.M. and Srivastava, B.S.: Application of cloning techniques to the

development of a synthetic vaccine against schistosomiasis. Vet. Parasitol. 10, 1982,

255.

28. Sinha, V.B. and Srivastava, B.S.: Plasmid associated suppression of pathogenicity of

some wild type strains of Vibrio cholerae isolated from human cholera patients. Ind. 

J. Med. Res. 77, 1983 1.

29. Barker, R.H., Srivastava, B.S., Goldberg, M. and Knopf, P.M. : Immunoprecipitation

analysis of radiolabelled antigens synthesized in vitro by S. mansoni I. Identification

of antigens uniquely recognized by protective antibodies.  J.  Immunol. 134, 1985,

1129.

30. Khan,  A.A., Srivastava, R., Sinha, V.B. and Srivastava, B.S.: Regulation of toxin

biosynthesis by plasmids in Vibrio cholerae. J. Gen. Microbiol. 131, 1985, 2653.

31. Srivastava, R., Khan, A.A. and Srivastava, B.S.: Immunological detection of cloned

antigenic genes of Vibrio cholerae in Escherichia coli. Gene, 40, 1985, 267.

32. Srivastava, R. and Srivastava, B.S.: Molecular biology of the mating types in yeast

Saccharomyces cerevisiae. Jour. Pl. Sci. Res. 1, 1985, 48.

33. Sinha, V.B. and Srivastava, B.S.: Colonization and protection in infant rabbits by a

choleragenoid producing strain of Vibrio cholerae. Ind. J. Med. Res. 84, 1986, 139.

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34. Srivastava, R., Sinha, V.B. and Srivastava, B.S.: Chromosomal transfer and in vivo

cloning of genes in Vibrio cholerae using RP4:: mini-Mu. Gene, 75, 1989, 253.

35. Srivastava, R., Ali, S.S. and Srivastava, B.S.: Cloning of xylanase gene of

Streptomyces flavogriseus in Escherichia coli and bacteriophage lambda induced

lysis for the release of cloned enzyme. FEMS Microbiol Lett. 78 (2/3) 1991, 20.

36. Czeczulin, J.R., Srivastava, R., Srivastava, B.S. and Kaper, J.B. : Characterization of a

possible colonization factor of Vibrio cholerae 01. Proc. Amer. Soc. Microbiol, 1990,

108.

37. Kaper, J.B. and Srivastava, B.S. : Genetics of cholera toxin.  Ind. J. Med. Res. 1992,

163.

38. Jacob, A., Sinha, V.B., Sahib, M.K., Srivastava, R., Kaper, J.B. and Srivastava, B.S.:

Identification of a 33 kDa antigen associated with an adhesive and colonizing strain

of Vibrio cholerae el tor and its role in protection. Vaccine, 11, 1993, 376.

39. Sinha,V.B. , Jacob, A., Srivastava R. , Kaper, J.B and Srivastava, B.S.: Identification of

the flagellar antigens of Vibrio cholerae el tor and their role in protection. Vaccine, 

11, 1993, 372.

40. Srivastava, B.S.: Pathogenesis of cholera and vaccine development. Proc. Ind. Nat. 

Sci. Acad., 59B, 1993, 459.

41. Krishna Kumar, K, Srivastava,R, Sinha, V.B. Mechalski, J., Kaper, J.B. and Srivastava,

B.S. recA mutations reduce adherence and colonization of classical and el tor

strains of Vibrio cholerae. Microbiology 140, 1994, 1217.

42. Chandrasekhar, U., Sinha, S., Bhagat, H.K., Sinha, V.B. and Srivastava, B.S.:

Comparative efficacy of biodegradable liposomes and microspheres as carriers for

delivery of V.cholerae antigens in the intestine. Vaccine 12, 1994, 1384.

43. Singh, S.N., Srivastava, R., Sinha, V.B. and Srivastava, B.S. : A 53 kDa protein of

Vibrio cholerae classical strain 0395 involved in intestinal colonization. Microbial 

Pathogenesis 17, 1994, 69.

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44. Kumar, D., Srivastava, B.S., Singh, N.B. and Srivastava, R.: Identification of a 25 kDa

protein of Mycobacterium bovis BCG to distinguish BCG from Mycobacterium

tuberculosis. J. Clin. Microbiol. 34, 1996, 224.

45. Srivastava, R., Kumar, D., Subramaniam, P., Srivastava, B.S.: - galactosidase

reporter system in mycobacteria and its application in rapid antimycobacterial drug

screening. Biochem. Biophys. Res. Commun. 235,   1997, 602.

46. Srivastava, R., Kumar, D., and Srivastava, B.S.: Recombinant Mycobacterium aurum

expressing Escherichia coli -galactosidase in high through put screening of

antituberculosis drugs. Biochem. Biophys. Res. Commun. 240, 1997, 536.

47. Bondre, V.P., Srivastava, R., Sinha, V.B., and Srivastava, B.S. : Screening of TnphoA

mutants of Vibrio cholerae 0139 for identification of antigens involved in

colonization. J. Med. Microbiol. 46, 1997, 1007.

48. Bondre, V.P., Sinha, V.B. and Srivastava, B.S. : Evaluation of different subcellular

fractions of Vibrio cholerae 0139 in protection to challenge in experimental cholera.

FEMS Immunol. Med. Miccrobiol. 19, 1998, 323.

49. Shukla, A., Dubey, M.P., Srivastava, R. and Srivastava, B.S .: Differential expression

of proteins during healing of cutaneous wounds in experimental and normal and

chronic models. Biochem. Biophys. Res. Commun. 244, 1998 434.

50. Kumar, D., Srivastava, B.S. and Srivastava, R.: Genetic rearrangements leading to

disruption of heterologous gene _expression in mycobacteria: An observation with

-galactosidase in Mycobacterium smegmatis. Vaccine, 16, 1998, 1212.

51. Srivastava, R., Deb, D.K., Srivastava, K.K. Locht, C. and Srivastava, B.S.: Green

fluorescent protein as a reporter in rapid screening of antituberculosis compounds

in vitro and in macrophages. Biochem. Biophys. Res. Commun.. 253, 1998, 431.

52. Chaturvedi, V., Srivastava A., Gupta, H.P. and Srivastava, B.S. : Protective antigens

of Mycobacterium habana are distributed between peripheral and integral

compartments of plasma membrane: a study in experimental tuberculosis of

mouse. Vaccine 17, 1999, 2882.

53. Srivastava, R. and Srivastava, B.S.: Tuberculosis vaccines. IDrugs, 3, 2000, 408.

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54. Deb, D.K., Srivastava, K.K., Srivastava, R. and Srivastava, B.S. : Bioluminescent

Mycobacterium aurum expressing firefly luciferase for rapid and high throughput

screening of antimycobacterial drugs in vitro and in infected macrophages.

Biochem. Biophys. Res. Comm. 279, 2000, 457.

55. Srivastava, R. and Srivastava, B.S. : Tuberculosis vaccines: a critical role for T-cells.

Curr.  Opinion Anti-inflammatory  &  Immunomodulatory Investigational  Drugs 2 

(2), 2000, 100.

56. Pathak R., Pant, C. S., Shaw, a.K., Bhaduri, A. P., Gaikwad, A. K., Sinha, S., Srivastava,

A., Srivastava, K. K., Chaturvedi, V., Srivastava, R., Srivastava, B.S. : Baylis-Hillman

Reaction: Convenient ascending synthetesis and biological evaluation of acyclic

deoxy monosaceharides as potential antimycobacterial agents. Biorg. Med. Chem. 

10, 2002, 3187.

57. Pathak, R., Shaw, A.K., Bhaduri, A.P., Chandrasekhar, K.V.G., Srivastava, A.,

Srivastava, K. K., Chatturvedi, V., Srivastava, R. , Srivastava, B.S., Arora, S. and Sinha,

S. : Higher acyclic nitrogen containing deoxy sugar derivatives: a new lead in the

generation of antimycobacterial chemotherapeutics. Biorg. Med. Chem. 10, 2002,

1695.

58. Tripathi, R.P., Tripathi, R., Tiwari, V.K., Bala, L., Sinha, S., Srivastava, A., Srivastava,

R. and Sivastava, B. S. : Synthesis of glycosylated B-amino acids as new class of

antitubercular agents. Eur. J. Med. Chem.  37, 2002, 773.

59. Deb, D.K., Dahiya, P., Srivastava, K. K., Srivastava. R. and Srivastava, B.S. : Selective

identification of new therapeutic targets of Mycobacterium tuberculosis by IVIAT

approach. Tuberculosis 82, 2002, 175.

60. Prem Raj, P., Srivastava, S., Jain, S.K., Srivastava, B. S. and Srivastava, R. : Protection

by live Mycobacterium habana cvaccine against Mycobacterium tuberculosis H37Rv

challenge in mice. Indian J.  Med. Res. 117, 2003, 139.

61. Tewari, N., Tiwari, V.K., Misra, R.C., Tripathi, R.P., Srivastava, A.K., Ahmed, R.,

Srivastava, R. and Srivastava, B.S. : Synthesis and bioevaluation of glycosyl ureas as a

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-glucosidase inhibitors and antituberculosis agents. Bioorg. Med. Chem. 11, 2003,

2911.

62. Katiyar, D., Tiwari, V. K., Tripathi, R. P., Srivastava, A., Chaturvedi, V., Srivastava,

R. and Srivastava, B. S. : Synthesis an antimycobacterial activity of 3,5-disubstituted

thiadiazine thiones. Bioorg. Med. Chem. 11, 2003, 4369.

63. Mishra, A., Srivastava, R., Pruzzo, C. and Srivastava, B. S. : Mutation in tcpR gene

(Vc0832) of Vibrio cholerae O1 causes loss of tolerance to high osmolarity and

affects colonization and virulence in infant mice. J. Med. Microbiol. 52, 2003, 1.

64. Tiwari, V.K., Tripathi, R.P., Chaturvedi, V., Srivastava, A., Sinha, S., Srivastava,

R.Srivastava, B.S. Combinatorial and conventional synthesis of glycohybrid molecules

as new class of antitubercular agents. Med. Chem. Res. 12, 2003, 394.

65. Gautam Panda, Shagufta , Jitendra Kumar Mishra, Vinita Chaturvedi, Anil K.

Srivastava, Ranjana Srivastava and Brahm S. Srivastava 2004. Diaryloxy methano

phenanthrenes: a new class of antituberculosis agents..Biorg. Med. Chem. 12 . 5269 .

66. Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and

antifungal agents. N. Tewari, V. K. Tiwari, R. P. Tripathi, A. Gaikwad, S. Sinha, P. K.

Shukla, R. Srivastava and B. S. Srivastava, Bio. Med. Chem.Lett., 2004, 12, 329.

67. D. Katiyar, V.K. Tiwari, N. Tiwari, S.S. Verma, S. Sinha, A. Gaikwad, A. Srivastava, V.,

Chaturvedi, R. Srivastava, B.S. Srivastava and R.P. Tripathi 2005. Synthesis of

antimycobacterial activity of Glosylated Aminesand Amino Alcohols.. Eur.   J.  Med. 

Chem.40, 351.

68. M. Zampini, C. Pruzzo, V.P. Bondre, R. Tarsi, M. Cosmo, A. Bacciaglia, A. Chabbra, R.

Srivastava, B.S. Srivastava.. 2005. Vibrio cholerae persistence in aquatic environments

and colonization of intestinal cells: involvement of a common adhesion mechanism.

FEMS Microbiol. Lett. 244 , 267.

69. Synthesis and antitubercular activities of bis-glycosylated diamino alcohols.  R.P.

Tripathi, V. K. Tiwari, N. Tewari, D. Katiyar, N. Saxena, S. Sinha, A. Gaikwad, A. K.

Srivastava, V. Chaturvedi, Y. K. Manju, R. Srivastava, B. S. Srivastava. Bioorg Med

Chem., 2005, 13, 5668.

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70. Ranjana Srivastava, D. Kumar, M.N. Waskar, M. Sharma, V.M. Katoch and B.S.

Srivastava. 2006. Identification of a repetitive sequence belonging to a PPE gene of

Mycobacterium tuberculosis and its use in diagnosis of tuberculosis . J.   Med. 

Microbiol. 55, 1071.

71. Ravi K. Asthana,, Arunima Srivastava, Akhilesh P. Singh, Deepali, Sureshwar P. Singh,

Gopal Nath, Ranjana Srivastava and Brahm S. Srivastava. 2006. Identification of an

antimicrobial entity from the cyanobacterium Fischerella sp. isolated from bark of

Azadirachta indica (Neem) tree . J. Applied Phycology 18 (1), 33.

72. P. Akhtar, S. Srivastava, Anil Srivastava, Mukesh Srivastava, Brahm S. Srivastava,

Ranjana Srivastava 2006. Rv3303c of Mycobacterium tuberculosis protects tubercle

bacilli against oxidative stress in vivo and contributes to virulence in mice. Microbes 

and infection 8, 2855-2862.

73. Srivastava, V., C. Rouanet, R. Srivastava, B. Ramalingam, C. Locht and B.S. Srivastava.

2007. Macrophage specific M. tuberculosis genes identified by green fluorescent

protein and kanamycin resistance selection. Microbiology 153 (Pt 3) 659-66. 48.

74. Saquib, M., Manish K. Gupta, Ram Sagar, Yenamandra S. Prabhakar , Arun K. Shaw,

Rishi Kumar, Prakash R. Maulik, Anil Gaikwad, Sudhir Sinha, Anil K. Srivastava, Vinita

Chaturvedi, Ranjana Srivastava and Brahm S. Srivastava..2007. C-3 Alkyl /Arylalkyl-

2,3-dideoxy hex-2-enopyranosides as antitubercular agents: Synthesis, Biological

Evaluation and QSAR study. J. Med. Chem., 2007, 50, 2942.

75. V. Srivastava, A. Jain, B.S. Srivastava, R. Srivastava. 2008. Selection of genes of

Mycobacterium tuberculosis upregulated during residence in lungs of infected mice.

Tuberculosis (Edinb). 88 (3) 171.

76. A. Saxena, V. Srivasrtava, R. Srivastava, B.S. Srivastava. 2008. Identification of genes

of Mycobacterium tuberculosis upregulated during anaerobic persistence by

fluorescence and kanamycin resistance selection. Tuberculosis (Edinb), 88 (6) 518.

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77. R.P.S. Parti, R. Shrivastava, S. Srivastava, A.R. Subramanian, R. Roy, B.S. Srivastava,

R. Srivastava. 2008. . A transposon insertion mutant of Mycobacterium fortuitum

attenuated in virulence and persistence in a murine infection model that is

complemented by Rv3291c of Mycobacterium tuberculosis. Microbial  Pathogenesis.

45(5-6), 370.

78. A. Gupta, S. Bhakta, S. Kundu, M. Gupta, B.S. Srivastava, R. Srivastava. 2009. Fast-

growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium

aurum: a model for high-throughput antituberculosis drug screening. J. Antimicrob. 

Chemotherapy 64(4), 774.

79. J. Kundu, R. Mazumdar, R. Srivastava, B.S. Srivastava. 2009. Intranasal

immunization with recombinant toxin-coregulated pilus and cholera toxin B subunit

protects rabbits against Vibrio cholerae 01 challenge. Fems     Immunol Med 

Microbiol. 56(2), 179.

80. R.K. Asthana, A. Deepali, M.K. Tripathi, A. Srivastava, A.P. Singh, S.P. Singh, G. Nath,

R. Srivastava, B.S. Srivastava. 2009. Isolation and identification of a new antibacterial

entity from the Antarctic cyanobacterium Nostoc CCC 537. Journal   of   Applied 

Phycology 21(1), 81.

81. R. K. Gupta, B.S. Srivastava, R. Srivastava. 2010. Comparative expression analysis of

rpf-like genes of Mycobacterium tuberculosis H37Rv under different physiological

stress and growth conditions. Microbiology, 156 , 2714.

82. Singh VK, Srivastava V, Singh V, Rastogi N, Roy R, Shaw AK, Dwivedi AK, Srivastava R,

Srivastava BS. 2011. Overexpression of Rv3097c in Mycobacterium bovis BCG

abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis

infection in mice.Vaccine. 2011;29(29-30):4754-60.

83. Saquib M, Husain I, Sharma S, Yadav G, Singh VK, Sharma SK, Shah P, Siddiqi MI,

Kumar B, Lal J, Jain GK, Srivastava BS, Srivastava R, Shaw AK.2011. 2,3-dideoxy hex-2-

enopyranosid-4-uloses as promising new anti-tubercular agents: design, synthesis,

biological evaluation and SAR studies.Eur J Med Chem. 2011 46(6):2217-23.

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84. Singh V, Chandra D, Srivastava BS, Srivastava R 2011. Biochemical and transcription

analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis

identifies these enzymes as potential targets for drug development.Microbiology. 

;157(Pt 1):29-37.

85. Singh V, Chandra D, Srivastava BS, Srivastava R 2011. Downregulation of Rv0189c,

encoding a dihydroxyacid dehydratase, affects growth of Mycobacterium tuberculosis

in vitro and in mice. Microbiology. ;157(Pt 1):38-46.

86. Sharma SK, Moe TS, Srivastava R, Chandra D, Srivastava BS. 2011. Functional

characterization of VC1929 of Vibrio cholerae El Tor: role in mannose-sensitive

haemagglutination, virulence and utilization of sialic acid. Microbiology.;157(Pt

11):3180-6.

87. Kashyap VK, Gupta RK, Shrivastava R, Srivastava BS, Srivastava R, Parai MK, Singh P, Bera

S, Panda G. 2012. In vivo activity of thiophene-containing trisubstituted methanes

against acute and persistent infection of non-tubercular Mycobacterium fortuitum in a

murine infection model. J Antimicrob Chemother. ;67(5):1188-97.

    List of Patents: 

International Patents granted :   5

Mycobacterium tuberculosis specific DNA fragment

US Patent no. 6,242,585 B1; 05. 06. 2001

Ranjana Srivastava, Deepak Kumar, B.S. Srivastava

Mycobacterium tuberculosis specific DNA fragment

US Patent no. 6114514; 05. 09. 2000

Ranjana Srivastava, Deepak Kumar, B.S. Srivastava

Mycobacterium tuberculosis specific DNA fragment

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European Patent EP0945462; 08/02/2006

Germany, England, France and Netherland

Ranjana Srivastava, Deepak Kumar, B.S. Srivastava

Antitubercular extracts of Salicornia brachiata

US Patent 20070020351; 25.1.2007

Meena Rajnikant Rathod, Bhupendra Dhanvantrai Shethia, Jayant Batukral Pandya,

Pushpito Kumar Ghosh, Prakash Jagivanbhal Dodia, Brahm S. Srivastava, Ranjana

Srivastava, Anil Srivastava, Vinita Chaturvedi, Mariappanadar Vairamani

Herbal extracts of Salicornia species, process of preparation thereof, use thereof

against tuberculosis preparation thereof, use thereof against tuberculosis

US Patent 20070248704; 25.10.2007

Meena Rajnika Rathod, Bhupendra D. Shethia, Jayant B.Pandya, Pushpito K. Ghosh,

Prakash J. Dodia, Brahm S. Srivastava, Ranjana Srivastava,  Anil Srivastava, Vinita

Chaturvedi.

National Patent :  22

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