SICKLE CELL ANEMIA AND TYPES OF MUTATIONS

Mutations

Video: Sickle Cell Anemia

http://www.youtube.com/watch?v=F3RHJcLYcm8

Discussion: Eddy

Why did Eddy have Sickle Cell Anemia?

What was different about Eddy’s red blood cells?

What effects did this have on Eddy’s body?

So what kind of mutation might have caused this???

Go to this website and play around with this game:

http://www.nature.ca/genome/04/0413_e.cfm#010

Fill out the worksheet with a partner as you explore this activity

Class Discussion: Types of Mutations

What type of mutation(s) seem to have no effect on your name?

How would this mutation affect protein synthesis in your body?

What types of mutation(s) had little effect on your name?

How would this mutation affect protein synthesis in you body?

What was the most serious type of mutation? Why?

How would this mutation affect protein synthesis in your body

So what kind of mutation caused Sickle Cell Anemia in Eddy?

Small-Scale Mutations

Point Mutations Missense

Nonsense

Silent

Insertion

Deletion