Shared Health Research Information Network

Andrew McMurry, MSSHRINE Architect

Harvard Medical School Center for BioMedical Informatics Children’s Hospital Informatics Program Harvard/MIT HST

Boston University Bioinformatics PHD Student

Andrew_McMurry(@) hms.harvard.edu

Current Status, Demo, and Open Source

History of the SHRINE world in 1 minute

Partners RPDR i2b2 Data Repository Shawn Murphy et all (wont steal their thunder here) Everyday patient encounters huge research cohorts

SPIN cross-hospital query model Extract, Transform <de-identifiy, autocode>, Load Federated query over multiple independent hospitals

Harvard CTSA funded

Recombinant deploying i2b2 across the country

Overly simplified: clinical data repository + federated query = SHRINE

SHRINE Technical Architecture

Bird’s Eye View Leverage local i2b2 deployments

Broadcast queries and aggregate responses across autonomous sites as if they were “one clinical data warehouse”

There is no central database

Connect sites in a peer-to-peer or hub-spoke fashion

ArchitectureTechnical Architecture, “cell” view

Current Status : in BETA!

East Coast : Harvard Effort BETA system running at Harvard across BIDMC, Children’s,

and Partners representing both BWH and MGH.

Last AUG: Prototype 1 year of data with demographics and

diagnosis IRB approval for demonstration only

NOW Patient data from 2001+ Demographics, Diagnosis, Medications, some Labs Full IRB approvals

Current Status : in BETA!

Demo use cases, things to think about…..

Lung cancer cases requesting biospecimens

Irritable Bowel Syndrome requesting sized cohorts

Pediatric rheumatology Creating national registry

Current Status

West Coast : CICTR Effort

University of WashingtonUCSF UC Davis

Nick Anderson et all

Current Status

National Registry : Pediatric Rheumatology

“Grand Opportunity” Grant

60 institutions, 2 years SHRINE has been selected as inter-institutional glue Consented patients, prospective data collection Shared Virtual Machine Hosting

SHRINE Open Source : brewing in the background

Fast recap of 2006 and 2009 Open Source proposals:

1. Write documentation as if we are writing code stubs Preconditions + Steps (Algorithm) + Post-conditions = Use Cases or “Scenarios”

2. Test driven development Write the test first Implement second Regression test everything all the time

Continuous Integration 1. Test everything every time you change any code

SHRINE Open Source Process Leveraging routine development activities

1. Public access to bug tracking system

2. Public access to latest source code

3. Public mailing lists• Shrine-users • Shrine-developers• Shrine-announce

4. Test Driven Development

5. Continuous integration (daily builds of the complete software)

Acknowledgements: Core SHRINE team

Zak Kohane (SHRINE Lead / HMS)Griffin Weber (HMS CTO / bidmc)Shawn Murphy (I2B2 CRC / partners) Dan Nigrin (Children’s CIO)Ken Mandl (Public Health Use Cases/ CHIP IHL)Sussane Churchill (I2B2 Executive director)Doug Macfadden (HMS CBMI IT Director)Matvey Palchuck (Ontology Lead / HMS)Andrew McMurry (Architect / HMS)

Could give an entire talk on all the collaborators, multi-institutional effort. Asking forgiveness from those not listed

Acknowledgements: Core SPIN team

Zak Kohane (SPIN PI / HMS)Frank Kuo (PSL Program Director / BWH)

John Gilbertson (PSL Pathologist / MGH)Mark Boguski (PSL Pathologist / BIDMC)Antonio Perez (PSL Pathologist / Children’s)Mike Banos (PSL Developer / BWH )Ken Mandl (Biosurviellance PI/ Children’s) Clint Gilbert (Biosurviellance Dev Lead / Children’s) Greg Polumbo (SPIN Developer/ HMS) Ricardo Delima (SPIN Developer / NCI at HMS) Britt Fitch (SPIN Developer / HMS

http://spin.chip.org/community.html

Acknowledgements: Core I2b2 team

https://www.i2b2.org/about/structure.html

Thank You

http://catalyst.harvard.edu/shrine

Andrew_McMurry (@) hms.harvard.edu