1
Known adverse reactions: Hypersensitivity/allergy, gastrointestinal discomfort, dizziness, headaches, malaise, and skin reactions have been known to occur; in which case, patients should discontinue use and consult a healthcare practitioner. Cautions and warnings: Treatment should be avoided during pregnancy and breastfeeding. The patient should be advised to consult a healthcare practitioner: • if symptoms of chronic venous disease persist or worsen, or in the event of inflammation of the skin, thrombophlebitis or subcutaneous induration, severe pain, ulcers, sudden swelling of one or both legs, cardiac or renal insufficiency or disorder; • if symptoms of hemorrhoids persist or worsen, if acute hemorrhoidal episode persists after 7 days, or if hemorrhoids are accompanied by rectal bleeding or a change in bowel habits; • prior to taking prescription medication. For more information: See Warnings, Cautions, and Directions of Use at https://health-products.canada.ca/lnhpd-bdpsnh/index-eng.jsp for information to assist in benefit-risk assessment. Always direct the patient to read the label. The Terms of Market Authorization are also available upon request by calling 1-888-902-9700. Reference: 1. Venixxa™ Product Licence. Servier Canada Inc., 2017. © 2017 Servier Canada Inc. Venixxa™ is a trademark of Servier Canada Inc. Quantity per box in patients with mild-to-moderate chronic venous disease: Introducing Venixxa™: A NEW oral treatment option IN patients with mild-to-moderate chronic venous disease and hemorrhoids 1 TM Recommended dose and duration of use in mild-to-moderate chronic venous disease: 1 • Should be used for a minimum of 2 months to see beneficial effects • If response is inadequate or unsatisfactory after 2 months, reconsider diagnosis, as edema may have alternative causes Recommended dose and duration of use in acute hemorrhoids (1-week treatment course): 1 Recommended dose and duration of use in hemorrhoids: 1 • Patient should consult a healthcare practitioner for use beyond 2 months 1 tablet twice daily 1 tablet twice daily, midday and evening with meals 3 tablets twice daily For the first 4 days 2 tablets twice daily For the next 3 days Recommended use in mild-to-moderate chronic venous disease: 1 Helps to reduce lower-leg edema associated with mild-to-moderate chronic venous disease • Helps to relieve signs and symptoms of mild-to-moderate chronic venous disease, such as varicose and spider veins, pain in the legs, sensation of heaviness, sensation of swelling, and functional discomfort Quantity per box in patients with hemorrhoids: VEMLG0318E Recommended use in hemorrhoids: 1 Helps to reduce signs and symptoms associated with hemorrhoids, such as anal discharge, bleeding, discomfort, inflammation (proctitis), itching (pruritus), pain, redness (erythema), sensation of needing to pass stools (tenesmus), and swelling (edema) Helps to reduce the duration, intensity, and recurrence of acute hemorrhoidal episodes SERVIER CANADA INC. 235, boulevard Armand-Frappier, Laval, QC H7V 4A7 www.servier.ca | 1-888-902-9700 Chronic venous disease 7 71547 00411 9 7 71547 00412 6 80078651 Hemorrhoids UPC NPN NOW available to order! 30 tablets (500 mg each) 30 x McKesson 119182 119183 Kohl & Frisch 158813 158814 Chronic venous disease Hemorrhoids Distributors 36 tablets (500 mg each) 36 x

SER 85509 Venixxa PharmaDirect letter ENKnown adverse reactions: Hypersensitivity/allergy, gastrointestinal discomfort, dizziness, headaches, malaise, and skin reactions have been

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Page 1: SER 85509 Venixxa PharmaDirect letter ENKnown adverse reactions: Hypersensitivity/allergy, gastrointestinal discomfort, dizziness, headaches, malaise, and skin reactions have been

Known adverse reactions:Hypersensitivity/allergy, gastrointestinal discomfort, dizziness, headaches, malaise, and skin reactions have been known to occur; in which case, patients should discontinue use and consult a healthcare practitioner.

Cautions and warnings:Treatment should be avoided during pregnancy and breastfeeding. The patient should be advised to consult a healthcare practitioner:• if symptoms of chronic venous disease persist or worsen, or in the

event of inflammation of the skin, thrombophlebitis or subcutaneousinduration, severe pain, ulcers, sudden swelling of one or both legs,cardiac or renal insufficiency or disorder;

• if symptoms of hemorrhoids persist or worsen, if acute hemorrhoidalepisode persists after 7 days, or if hemorrhoids are accompanied byrectal bleeding or a change in bowel habits;

• prior to taking prescription medication.

For more information:See Warnings, Cautions, and Directions of Use at https://health-products.canada.ca/lnhpd-bdpsnh/index-eng.jsp for information to assist in benefit-risk assessment. Always direct the patient to read the label. The Terms of Market Authorization are also available upon request by calling 1-888-902-9700.

Reference:1. Venixxa™ Product Licence. Servier Canada Inc., 2017.

© 2017 Servier Canada Inc.Venixxa™ is a trademark of Servier Canada Inc.

Quantity per box in patients with mild-to-moderate chronic venous disease:

Introducing Venixxa™: A NEW oral treatment option IN patients with mild-to-moderate chronic venous disease and hemorrhoids1

TM

Recommended dose and duration of use in mild-to-moderate chronic venous disease:1

• Should be used for a minimum of 2 months to see beneficial e�ects

• If response is inadequate or unsatisfactory after 2 months,reconsider diagnosis, as edema may have alternative causes

Recommended dose and duration of use in acute hemorrhoids (1-week treatment course):1

Recommended dose and duration of use in hemorrhoids:1

• Patient should consult a healthcare practitioner for usebeyond 2 months

1 tablet twice daily

1 tablet twice daily,midday and evening with meals

3 tablets twice daily

For the first 4 days

2 tablets twice daily

For the next 3 days

Recommended use in mild-to-moderate chronic venous disease:1

• Helps to reduce lower-leg edema associated with mild-to-moderate chronic venous disease • Helps to relieve signs and symptoms of

mild-to-moderate chronic venous disease, such as varicose and spider veins, pain in the legs, sensation of heaviness, sensation of swelling, and functional discomfort

Quantity per box in patients with hemorrhoids:

VEMLG

0318

E

Recommended use in hemorrhoids:1

• Helps to reduce signs and symptoms associated with hemorrhoids, such as anal discharge, bleeding, discomfort, inflammation (proctitis), itching (pruritus), pain, redness (erythema), sensation of needing to pass stools (tenesmus), and swelling (edema)

• Helps to reduce the duration, intensity, and recurrence of acute hemorrhoidal episodes

SERVIER CANADA INC.235, boulevard Armand-Frappier, Laval, QC H7V 4A7www.servier.ca | 1-888-902-9700

Chronic venous disease

7 71547 00411 9 7 71547 00412 6

80078651

Hemorrhoids

UPC

NPN

NOW available to order!

30 tablets (500 mg each)30 x

McKesson 119182 119183

Kohl & Frisch 158813 158814

Chronic venous disease HemorrhoidsDistributors

36 tablets (500 mg each)36 x

C

M

Y

CM

MY

CY

CMY

K

SER_85509_Venixxa_PharmaDirect_letter_EN.pdf 1 2017-10-26 3:24 PM