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Senior Research Leaders Professor Jon Bisson Professor Vanessa Burholt Professor Colin Dayan Professor Adrian Edwards Professor Kerry Hood Professor Dyfrig Hughes Professor William Gray Professor Ian Jones Professor Ronan Lyons

Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Page 1: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

Senior Research Leaders

Professor Jon Bisson Professor Vanessa Burholt Professor Colin Dayan

Professor Adrian Edwards Professor Kerry Hood

Professor Dyfrig Hughes

Professor William Gray

Professor Ian Jones Professor Ronan Lyons

Page 2: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

Page 2 of 21

Professor Paul Morgan Professor Shantini Paranjothy

Professor Andrew Sewell

Professor Helen Snooks Professor Rhiannon Tudor Edwards

Professor John Williams

Page 3: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Jon Bisson

Department and Institution Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University

Current Post Professor in Psychiatry

Primary Research Field Jon’s main research is in the field of traumatic stress - www.traumaticstressresearch.co.uk

Contact details [email protected] 02920 688 486

Biography

Jon was Director of Research and Development with Cardiff and Vale UHB from 2010 to

2013, Clinical Director of the National Institute for Social Care and Health Research Academic

Health Science Collaboration from 2011 to 2013, he then led the development of Health and

Care Research Wales and was its first Director until August 2018. He was co-chair of the UK’s

first PTSD NICE Guideline Development Group and chairs the International Society for

Traumatic Stress Studies’ Treatment Guidelines Committee. He developed the first liaison

psychiatry, traumatic stress and veterans’ mental health services in Wales and is currently

leading on the development of an all Wales traumatic stress quality improvement initiative.

Jon is a practising psychiatrist and professor in psychiatry at Cardiff University. He has

conducted various studies including two widely cited randomised controlled trials of early

psychological interventions following traumatic events and five Cochrane systematic reviews

in the traumatic stress field. He developed and continues to lead Cardiff University’s

Traumatic Stress Research Group and has been awarded 31 research grants worth over £10

million. His current research includes randomised controlled trials of a guided self-help

intervention for mild to moderate PTSD, and 3MDR for treatment-resistant PTSD in veterans.

He has over 160 publications, regularly teaches and supervises undergraduates,

postgraduates, health and other professionals. He has delivered over 150 presentations to

various meetings and conferences in 17 different countries, including 42 keynote/plenary

presentations.

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Page 4: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Vanessa Burholt

Department and Institution

College of Human and Health Sciences, Swansea University

Current Post

Professor of Gerontology

Director of Centre for Innovative Ageing

Director of Centre for Ageing and Dementia Research

Primary Research Field

Gerontology

Secondary Research Field

Social Sciences, Social Psychology

Contact details [email protected] 01792 602186

Biography

After graduating from the Open University in 1994, Vanessa worked as a researcher at Bangor

University while she undertook her PhD. After completing her PhD in 1998, Vanessa became

Deputy Director of the Centre for Social Policy Research and Development at Bangor

University and in 2004 took over as Director. Vanessa was awarded a personal Chair at Bangor

in 2007, and shortly after moved to Swansea University, as Director of the Centre for

Innovative Ageing. In 2016, Vanessa was also appointed Director of the pan Wales, Centre for

Ageing and Dementia Research.

Vanessa is the research member of the Ministerial Advisory Forum on Ageing. Personal awards

include Fellow of the Academy of Social Science and Senior Research Leader for Health and

Care Research Wales. In 2015 and 2017, she won the CHHS outstanding contribution to

research award. She was formerly a member of the ESRC Grants Assessment Panel C, ESRC

Peer Review College and ESRC DTC Peer Review College. She is member of the Board for

Health and Care Research Wales.

Vanessa has more than 20 years research experience in social gerontology and has worked on

and led international and national research projects worth approximately £51.9mil, and has

supervised 24 post-graduate students. Her research interests include loneliness, support

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networks, intergenerational relationships, social exclusion, rurality, migration of older people

and attachment to place and she has published more than 50 articles and book chapters on

these topics.

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Page 6: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Colin M Dayan

Department and Institution

Diabetes/Autoimmunity, Infection and Immunity Division, Cardiff

University School of Medicine

Current Post

Professor of Clinical Diabetes and Metabolism, Cardiff University

Professor of Endocrinology and Merabolism, University of Bristol

Primary Research Field

Type 1 diabetes, thyroid disease, autoimmunity

Secondary Research Field

Graves eye disease

Contact details [email protected] 029 2074 2182

Biography

Colin Dayan trained in medicine at University College, Oxford, and Guy’s and Charing Cross

Hospitals in London, UK before obtaining a PhD in the immunology of Graves’ Disease in

Laboratory of Marc Feldmann. He then spent a year as an endocrine fellow at the

Massachussetts General Hospital in Boston, USA before completing his specialist training in

diabetes and endocrinology as a Lecturer in Bristol. He became a consultant senior lecturer in

medicine (diabetes/endocrinology) at the University of Bristol in 1995 and Head of Clinical

Research at the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology

in Bristol in 2002. In 2010, he was appointed to the Chair of Clinical Diabetes and Metabolism

and Head of Section at Cardiff University School of Medicine. He served as Director of the

Institute of Molecular and Experimental Medicine in 2011 – 2015. In 2017 he was appointed

to the post of Professor of Endocrinology and Diabetes at the University of Bristol, UK as a

joint post with Cardiff. His research interests include the immunotherapy of type 1 diabetes

where he leads the UK immunotherapy consortium, thyroid hormone replacement therapy

and autoimmune thyroid disease. (https://www.cardiff.ac.uk/people/view/78690-dayan-

colin)

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Page 7: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Adrian Edwards

Department and Institution

School of Medicine, Cardiff University

Current Post

Co-Director, Division of Population Medicine

Primary Research Field

Prof Edwards' main research interests are in quality and safety of health care, with current

studies on safety in primary care, the epidemiology of harm in secondary care, self-

management support in long term conditions, and implementation of shared decision making.

Contact details [email protected] 02920 687196

Biography

Professor Adrian Edwards' main research interests are in quality and safety of health care,

with current studies on safety in primary care, the epidemiology of harm in secondary care,

self-management support in long term conditions, and implementation of shared decision

making.

Adrian is Professor of General Practice and Co-Director of the Division of Population

Medicine at Cardiff University. He is the Director of PRIME Centre Wales , an all-Wales Centre

for Primary and Emergency (including unscheduled research), in partnership with Bangor

University, Swansea University and University of South Wales. He is also a part-time general

practitioner in Cwmbran, South Wales, and has a visiting professorship at Aarhus University,

Denmark. He co-leads the Population Medicine Route of the intercalated BSc.

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Page 8: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor William Gray

Department and Institution

Primary Research Field

Contact details [email protected] 02920 688491

Professor Gray graduated in Medicine from University College Cork, Ireland, where he also obtained his MD in motor nerve transplantation. His post doctoral research was spent in Southampton and Bonn where he developed an interest in adult neural stem cells. He established a research group on adult neurogenesis in Southampton, and was appointed to the University Chair of Neurosurgery in 2006. He moved to the Chair of Functional Neurosurgery in Cardiff in 2011, where he established the BRAIN Biomedical Research Unit, and which he also directs.

His clinical interests are in epilepsy surgery and cognitive dysfunction in epilepsy. His research group’s work extends from lab-based basic science studying stem cells and adult hippocampal neurogenesis, to cognitive behavioural and imaging studies in patients and neural stem cell transplantation in Huntington’s Disease and epilepsy.

He is particularly interested in the effects of the innate immune system on endogenous and transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological disease.

Division of Psychological Medicine and Clinical Neurosciences, Neuroscience and Mental Health Research Institute, School of Medicine , Cardiff University

Current Post

Professor of Neurosurgery,Director, Brain Repair And Intracranial Neurotherapeutics (BRAIN) Unit Training Programme Director in Neurosurgery (HEIW)

Biography

Secondary Research Field

Neural Stem Cells

Neuroinflammation

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Page 9: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Kerry Hood

Department and Institution

Centre for Trials Research, Cardiff University

Current Post

Director

Primary Research Field

Clinical Trials

Secondary Research Field

Infections

Contact details [email protected] 02920 687163

Biography

Professor Hood has a degree and PhD in Statistics and has worked in medical statistics since

1996. She spent the first part of her career focused on research in primary care and then in

2006 established the South East Wales Trials Unit and started to develop a broader research

portfolio. Her specific methodological research interests are in trial design, outcome

measurement and research inclusion with a particular focus on complex trials, whilst the topic

areas she mainly focuses on are primary care, infections and learning disabilities.

Professor Hood collaborates widely across the UK and Europe on research studies from a

broad range of funders including NIHR, NISCHR, EU and industry. She has over 270 peer

reviewed research publications and currently holds £34M of research grants as a co-applicant.

She is a Fellow of the Royal Statistical Society and the Higher Education Academy and a

member of the Society for Academic Primary Care and the Society for Clinical Trials.

Professor Hood is keen to develop career pathways for researchers and is a mentor on the

Society for Academic Primary Care PHoCuS (Primary Healthcare Scientists) mentoring scheme.

She also mentors undergraduate medical students.

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Page 10: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Dyfrig Hughes

Department and Institution

Centre for Health Economics and Medicines Evaluation, Bangor

University.

Current Post

Professor of Pharmaeconomics.

Co-director of the Centre for Health Economics & Medicines.

Primary Research Field

Dyfrig’s principal interests are in pharmaceutical economics and policy, adherence research,

and methodological and applied research in trial-based economic evaluations.

Contact details [email protected] 01248 382950

Biography

Professor Dyfrig Hughes’ principal interests are in pharmaceutical economics and policy,

adherence research, and methodological and applied research in trial-based economic

evaluations.

Dyfrig graduated in pharmacy at Cardiff University before undertaking a PhD in cardiovascular

pharmacology at the University of Liverpool. He subsequently trained in health economics,

and is currently Professor of Pharmacoeconomics and co-director of the Centre for Health

Economics and Medicines Evaluation at Bangor University. He is also academic lead for

Pharmacy at the Betsi Cadwaladr University Health Board, and is honorary professor at the

Department of Molecular and Clinical Pharmacology, University of Liverpool.

Dyfrig’s main research activities, which have led to over 120 publications, concern

pharmaceutical economics and policy, health technology assessment and medication

adherence. He is an editorial board member of the journals PharmacoEconomics and Clinical

Pharmacology & Therapeutics.

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Page 11: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Ian Jones

Department and Institution

School of Medicine, Cardiff University

Current Post

Director/Clinical Professor, National Centre for Mental Health

Primary Research Field

Ian Jones is a Professor of Psychiatry at the Division of Psychological Medicine and Clinical

Neurosciences at Cardiff University. He is also an Honorary Consultant Psychiatrist in Cardiff

and Vale NHS Trust. His research interests relate to bipolar spectrum disorders and in

particular the relationship of mood disorders to childbirth. Professor Jones' clinical interest is

in the identification and management of women at high risk of severe postpartum episodes.

Contact details [email protected] 02920 688327

Biography

Ian Jones is a Professor of Psychiatry at the Division of Psychological Medicine and Clinical

Neurosciences at Cardiff University, and Honorary Consultant Psychiatrist in Cardiff and Vale

NHS Trust. He is also Director of the National Centre for Mental Health. He is the clinical lead

for the Cardiff University Psychiatry Service (CUPS) which offers second opinions for mood

and psychotic disorders and leads a clinical service offering pre-conception counselling to

women with severe mental illness. He is director of BEP-C, a group psychoeducation

programme for bipolar disorder. Ian is a trustee, past chair and scientific adviser to Action on

Postpartum Psychosis.

His research interests relate to bipolar spectrum disorders and in particular the relationship of

mood disorders to childbirth. Ian’s clinical interest is in the identification and management of

women at high risk of severe postpartum episodes.

Ian graduated from St Georges Medical School in London and then trained in General

Medicine and Psychiatry in South Wales. He joined Professor Craddock’s team in the mood

disorders group in Cardiff University as a clinical research fellow and was then awarded a

Wellcome Trust Training Fellowship at the University of Birmingham spending a year at

Virginia Commonwealth University in the US.

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Page 12: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Ronan Lyons

Department and Institution

Swansea University Medical School, Swansea University

Current Post

Clinical Professor of Public Health

Primary Research Field

Population Health

Secondary Research Field

Health Data Science

Contact details [email protected] 01792 513484

Biography

Ronan Lyons, Fellow of the Learned Society of Wales (FLSW), is Professor of Public Health at

Swansea University, Honorary Consultant in Public Health with Public Health Wales NHS Trust

and Adjunct Professor at Monash University, Australia.

Professor Lyons is Director of the National Centre for Population Health and Wellbeing

Research, Research Director and lead for Population Health Research for Health Data Research

UK and Co-Director of the Secure Anonymised Information Linkage (SAIL) system.

His research focuses on the use of routine data in cohorts, trials, and the evaluation of natural

experiments and complex interventions. He led the development of the total population

Wales Electronic Cohort for Children as a platform for evaluating interventions and policies.

He is principal investigator in the MRC funded ‘Application of machine learning to discover

new multimorbidity phenotypes associated with poorer outcomes’, a new collaboration with

the Alan Turing Institute, Associate Director for the MRC’s Dementias Research Platform UK

and lead investigator in the ESRC funded Administrative Data Research Partnership.

Professor Lyons is particularly interested in the neglected field of injury prevention and

control and is involved in many of the world's largest observational, interventional and policy

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relevant injury research studies. Since 2012, he has chaired the US National Centres for

Health Statistics’ International Collaborative Effort on Injury Statistics and Methods.

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Page 14: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Paul Morgan

Department and Institution

Division of Infection and Immunity, School of Medicine, Cardiff

University

Current Post

Professor of Immunology

Director, Systems Immunity URI

Primary Research Field

Complement Biology

Secondary Research Field

Neuroinflammation

Contact details [email protected] 02920 688320

Biography

Professor Morgan graduated in Medicine from Cardiff and completed a PhD prior to a two-year

stay in the US where he developed his interest in the Complement System. He returned to the

UK where, generously supported by the Wellcome Trust, he built a research group working on

the complement system, its regulation and roles in disease. He is a former Dean of Medicine

at Cardiff University and is currently Director of the Systems Immunity Research Institute and

co-Director of the Hodge Centre for Neuropsychiatric Immunology. His current research

focusses on roles of complement and other inflammatory pathways in disease with a

particular focus on neurological disease.

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Page 15: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Shantini Paranjothy

Department and Institution

Division of Population Medicine, School of Medicine, Cardiff

University

Current Post

Co-Director Division of Population Medicine

Primary Research Field

Population health and epidemiological analysis of record-linked routinely available health

and administrative data

Secondary Research Field

Perinatal and child health epidemiology

Contact details [email protected] 029 2068 7245

Biography

Professor Shantini Paranjothy is a public health physician and epidemiologist. Shantini was

appointed as the Mansel Talbot Professor of Preventive Medicine at Cardiff University in

2016.

Shantini’s research is focused on perinatal and infant health inequalities. In 2008, Shantini set

up the Welsh Study of Mothers and Babies (WOMBS) to study the significance of ultrasound

markers detected during pregnancy for the health of the baby (funded by MRC/WORD Health

Research Partnership Award). The study recruited 30,000 mothers from all maternity units in

Wales, with consent to follow up their children in future studies.

Shantini has led a number of large-scale epidemiological analyses using record-linked data

from routinely collected health and social data. One example was an analysis of birth

outcomes for women who have had treatment for cervical abnormalities. This study used

linked anonymised electronic records from a cohort of 174,325 women aged 20-39 years in

Wales and reassuringly found that surgical treatment for pre-cancerous lesions did not

increase the likelihood of premature birth or low birth-weight babies. Shantini has researched

health and social outcomes for vulnerable babies and children using the Wales Electronic

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Cohort for Children (WECC), the first complete population e-cohort in the UK of 800,000

children, aimed at investigating the widest possible range of social and environmental

determinants of child health and social outcomes by exploiting the potential of routinely

collected datasets.

Shantini is currently the Scientific Lead for HealthWise Wales

(www.healthwisewales.gov.wales), which is Health and Care Research Wales' flagship

initiative for a population health research cohort in Wales.

Shantini is also a Non-Executive Director on Public Health Wales NHS Trust Board, and Chair of

the Board’s Knowledge, Research and Innovation Committee.

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Page 17: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Andrew Sewell

Department and institution

School of Medicine, Cardiff University

Current Post

Distinguished Research Professor, Division of Infection and Immunity

Primary Research Fields

Immunology

Cancer Immunotherapy

Autoimmune Disease

Immunity to Infection

Transplant Tolerance

Contact details [email protected] 02920 687055

Biography

Professor Andy Sewell is Distinguished Research Professor in the Division Infection and

Immunity at Cardiff University School of Medicine and a Wellcome Trust Senior Investigator.

His work is focused on T-cell ligands and the receptors that recognise them. Current interests

within the group include autoimmunity, transplant tolerance, cancer immunotherapy, smart

vaccination and unconventional T-cells.

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Page 18: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Helen Snooks

Department and Institution

Medical School, Swansea University

Current Post

Professor of Health Services Research

Primary Research Field

Emergency Pre-hospital and Unscheduled Care

Secondary Research Field

Primary Care and research support

Contact details [email protected] 01792 513 418

Biography

Professor Helen Snooks is currently Professor of Health Services Research in the Medical

School at Swansea University. Professor Snooks leads the Patient and Population Health

Informatics research theme within the School. She is seconded for one and a half days a week

to the National Institute for Health Research Evaluation, Trials and Studies Coordinating

Centre (NETSCC) at University of Southampton, as Health Technology Assessment Journal

Editor and Senior Scientific Advisor to the Health Services and Delivery Research programme.

Professor Snooks led the Trials Unit in Swansea to full registration with the UKCRC, and

retains a strong interest in experimental evaluation methods and has a strong record of grant

capture, totalling 30 million.

Her main research interests and expertise lie in the fields of Emergency Pre-hospital and

Unscheduled Care, Primary Care, and research support. In these areas, the focus of her work is

to plan, design and carry out evaluations of health technologies and new models of service

delivery which often involve changing roles and working across boundaries between service

providers. The research is applied, pragmatic and leads to change and impact in the real world

of policy and practice. She actively encourages and supports public and patient involvement

in her research to enhance relevance, accountability and quality. Her work is strongly patient-

focused and collaborative, and uses mixed methods to achieve study aims.

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Page 19: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor Rhiannon Tudor Edwards

Department and Institution

College of Health and Behavioural Sciences, Bangor University

Current Post

Professor of Health Economics, Co-Director of the Centre for Health

Economics and Medicines Evaluation (CHEME), Director of the Welsh

Health Economics Support Service

Primary Research Field

Health Economics

Secondary Research Field

Medicines Evaluation

Contact details [email protected] 01248 382153

Biography

Rhiannon Tudor Edwards BSC. Econ, M.A., D.Phil., Hon. MFPH is Professor of Health Economics

and the founding Director of health economics research at Bangor University and Co-Director

of the Centre for Health Economics and Medicines Evaluation. She is also Director of the

Welsh Health Economics Support Service. Rhiannon has eight PhD students and teaches

Health Economics and Public Health Economics at postgraduate level.

Rhiannon works closely with Public Health Wales and was a UK Faculty of Public Health

examiner for three years. Rhiannon is registered blind, has been a guide dog owner for 15

years and has a growing interest in the application of health economics to

technologies/services to support people living with disability. She is currently part of an

international collaboration looking at low vision service models.

Professor Tudor Edwards graduated with degrees from the University of Wales, Aberystwyth

and the University of Calgary, Canada. She completed her PhD thesis at The University of York,

on NHS waiting lists as a rationing mechanism in public health care.

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Page 20: Senior Research Leaders · 2019-09-16 · transplanted neural stem cells, and how this may be manipulated to restore cognitive function and effect brain repair in patients with neurological

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Professor John Williams CBE

Department and institution

Swansea University Medical School

Current Post

Professor of Health Services Research

Primary Research Field

Gastroenterology

Secondary Research Field

Health Services

Health Informatics

Service Delivery

Patient Outcome

Contact details [email protected] 01792 513 401

Biography

Professor Williams is currently Professor of Health Services Research at Swansea University’s

College of Medicine. From 2002 - 2007 he was Wales Director of Research and Development,

a post in which he established the Clinical Research Collaboration in Wales.

Professor Williams’ main research interests are gastroenterology, health informatics, service

delivery, and patient outcome. He chiefly focuses on better diagnosis, treatments and services

- particularly in gastroenterology - and on increasing patient involvement in these

processes. He has researched novel means of outpatient services delivery and changing roles

in gastrointestinal endoscopy, and has led multicentre trials in inflammatory bowel

disease. He has evaluated the use of routinely collected data to support research, audit and

professional appraisal, highlighting the need for improvement in the quality of the data

recorded in patient records and clinical communications.

From 2001 to 2019 Professor Williams led Health Informatics at the Royal College of

Physicians where he drove the development of consensus based national standards for the

structure and content of patient records and communications. This work is now being taken

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forward by the Professional Record Standards Body, which he was instrumental in

establishing. He also drove the creation of the Faculty of Clinical Informatics, of which he is a

founding fellow.

In 2014 Professor Williams received a CBE for services to medicine.

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