SELECTED PUBLISHED CLINICALEVIDENCE LIST

Prevent Reherniation. Preserve Disc.

PUBLISHED PEER-REVIEWED JOURNAL MANUSCRIPTS WITH BARRICAID® DATA1. Spine (2013) 38(10) E587–E593

Can Prevention of A Re-Herniation Be Investigated?: Establishment Of A Herniation Model And Experiments With An Anular Closure DeviceHJ Wilke, L Widmann, F Heuer, N Graf, S Rath

2. Eur Spine J (2013) 22:1030–1036 The High-Risk Discectomy Patient: Prevention Of Reherniation In Patients With Large Anular Defects Using An Anular Closure Device GJ Bouma, M Barth, D Ledic, M Vilendecic

3. Korean J Spine (2012) 9(4):340-347 Primary Limited Lumbar Discectomy with an Annulus Closure Device: One-Year Clinical and Radiographic Results from a Prospeective, Multi-Center Study M Lequin, M Barth, C Thomé, GJ Bouma

4. Clin Neurol Neurosurg. 2013 Aug;115(8):1440-5 Protecting Facet Joints Post-Lumbar Discectomy: Barricaid Annular Closure Device Reduces Risk of Facet Degeneration M Trummer, S Eustacchio, M Barth, PD Klassen, S Stein

5. J Neurol Surg A Cent Eur Neurosurg. 2013 Sep;74(5):285-9 Cost Savings Associated with Prevention of Recurrent Lumbar Disc Herniation: A Multi-Center Prospective Cohort StudySL Parker, G Grahovac, D Vukas, D Ledic, M Vilendecic, MJ McGirt

6. Acta Clin Croat (2013) 52:87-91 Clinical Outcomes In Patients After Lumbar Disc Surgery With Anular Reinforcement Device; Two-Year Follow Up D Vukas, D Ledić, G Grahovac, Z Kolić, K Rotim, M Vilendečić

7. J Neurol Surg A 2015;76:211-218. Effect of Anular Closure on Disk Height Maintenance and Reoperated Recurrent Herniation Following Lumbar Diskectomy: Two-Year DataD Ledic, D Vukas, G Grahovac, M Barth, GJ Bouma, M Vilendecic

8. J Neurol Surg A 2015, DOI: 10.1055/s-0035-1570344 Effect of Annular Defects on Intradiscal Pressures in the Lumbar Spine: An in Vitro BiomechanicalStudy of Diskectomy and Annular RepairR Bostelmann, H-J Steiger, JF Cornelius

9. Clin Spine Surg. 2016 Dec;29(10):454-460Effect Of A Novel Annular Closure Device (Barricaid) On Same Level Recurrent Disc Herniation And Disc Height Loss After Primary Lumbar Discectomy: Two-Year Results Of A Multi-Center Prospective Cohort StudySL Parker, G Grahovac, D Vukas, M Vilendecic, D Ledic, MJ McGirt, EJ Carragee

10. Korean J Neurotrauma 2014;10(2):119-122Use of Annular Closure Device (Barricaid®) for Preventing Lumbar Disc Reherniation: One-Year Results of Three CasesBS Hahn, GY Ji, B Moon, DA Shin, Y Ha, KN Kim, DH Yoon

11. Int J Clin Trials. 2016 Aug;3(3):120-131A multicenter, prospective, randomized study protocol to demonstrate the superiority of a bone-anchored prosthesis for anular closure used in conjunction with limited discectomy to limited discectomy alone for primary lumbar disc herniationPD Klassen, R Hes, GJ Bouma, S Eustacchio, M Barth, A Kursumovic, S Jadik, V Heidecke, R Bostelmann,C Thomé, P Vajkoczy, HP Köhler, J Fandino, R Assaker, E Van de Kelft, S Fröhlich, W van den Brink, J Perrin, J Wolfs, M Arts, F Martens

PUBLISHED CONFERENCE PROCEEDINGS 13. BASS 2017 abstracts, The Spine Journal 17 (2017) S3-S22, Annual Meeting of the British Association of Spine Surgeons,

Manchester, United Kingdom, March 14-17, 2017Early readmission, delayed discharge, and reoperation after lumbar discectomy discectomy: an analysis from a multicenter, prospective, randomized studyGJ Bouma, PD Klassen, C Thome, Anular Closure R.C.T. Study Group, F Martens;

14. 11th Annual Meeting of the German Spine Society (DWG), Hannover, Germany, 1-3 December 2016Verlängerte Liegezeit und frühe Wiederaufnahme nach Nukleotomie – Analyse einer multizentrischen,prospektiven, randomisíerten Studie über Nukleotomie versus Nukleotomie mit Anulus Verschluss – Ergebnisseder deutschen ZentrenR Bostelmann, A Kursumovic, V Heidecke, S Fröhlich, M Barth, J Perrin, S Jadik, P Vajkoczy, E von Saldern, PD Klassen

15. Eur Spine J (2015) 24:2614—2707; 10th Annual Meeting of the German Spine Society (DWG), Frankfurt, Germany, 10-12 December 2015Lumbar Discectomy Patients at High Risk of Reherniation: Confirming Carragee´s Massive-Defect Results in a German PopulationC Thome, R Bostelmann, V Heidecke, M Barth, A Kursumovic

16. Eur Spine J (2015) 24:2614—2707; 10th Annual Meeting of the German Spine Society (DWG), Frankfurt, Germany, 10-12 December 2015Real World Experience with an Anular Closure DeviceA Kursumovic, S Rath

17. Value In Health 17 (2014) A323 – A686; ISPOR 17th Annual European Congress, 8 November 2014, Amsterdam, The NetherlandsCost-Effectiveness Of Use Of Barricaid® In Lumbar Discectomy Surgery In Turkey M Tatar, A Senturk, Y Dalgali

18. Eur Spine J (2014) 23:2473–2569 | DOI 10.1007/s00586-014-3600-8; 9th Annual Meeting of the German Spine Society, Leipzig, Germany, 11-13 December 2014Mri-Changes In Patients 2 Years After Sequestrectomy Alone Versus Sequestrectomy With Anulus Closure A Carolus, K Schmieder, C Thomé, GJ Bouma, M Barth

19. Eur Spine J (2014) 23:2473–2569 | DOI 10.1007/s00586-014-3600-8; 9th Annual Meeting of the German Spine Society, Leipzig, Germany, 11-13 December 2014Preliminary Two-Year Safety Data for an Anular Closure Device: German Experience from a Multicenter, Prospective, Randomized Clinical TrialM Czabanka, A Kursumovic, R Bostelmann, M Barth, V Heidecke, M Mehdorn, A. Hegewald, S Fröhlich, H.-P. Köhler, PD Klassen

20. Eur Spine J (2014) 23:2473–2569 | DOI 10.1007/s00586-014-3600-8; 9th Annual Meeting of the German Spine Society, Leipzig, Germany, 11-13 December 2014Can Anular Closure Device Improve the Outocme of Discectomies? Clinical and Real World Experience with Anular Closure at a Single SiteA Kursumovic, S Rath

21. Eur Spine J (2014) 23:2473–2569 | DOI 10.1007/s00586-014-3600-8; 9th Annual Meeting of the German Spine Society, Leipzig, Germany, 11-13 December 2014Recurrent Lumbar Disc Herniation: Treatment with a Bone- Anchored Anular Closure DeviceA Kursumovic, R Hes, GJ Bouma, M. Barth, V Heidecke, A Hegewald, F Martens, C Thomé, J Kienzler, PD Klassen,S. Rath

22. J Neurol Surg A Cent Eur Neurosurg 2014; 75 - p27 | DOI: 10.1055/s-0034-1383763; Joint Annual Meeting 2014, Zurich, Switzerland, 12-13 June 2014Early Two-Year Safety Data for an Annular Closure Device: Interim Results from a Multicenter, Prospective, Randomized Clinical TrialJ Kienzler, J Fandino, F Martens, R Hes, GJ Bouma, Anular Closure RCT Study Group, PD Klassen

12. Journal of Clinical Neuroscience 34 (2016) 288–293Occurrence of discal and non-discal changes after sequestrectomy alone versus sequestrectomy and implantation of an anulus closure deviceM Barth, J Fontana, C. Thomé, C.J. Bouma, K. Schmieder

SCIENTIFIC PROCEEDINGS23. 46th ISSLS (International Society for the Study of the Lumbar Spine), Athens, Greece, 29 May - 2 June, 2017

Defect Size And Lumbar Reherniation: Identifying The High-Risk Patient N Kögl, M Arts, Anular Closure RCT Study Group, F Martens, J Fandino, PD Klassen

24. 46th ISSLS (International Society for the Study of the Lumbar Spine), Athens, Greece, 29 May - 2 June, 2017Discectomy With And Without Bone-Anchored Anular Closure For High-Risk Disc Herniation Patients: Complete Early Readmission And Delayed Discharge Analysis From A Multicenter, Prospective, Randomized StudyN Kögl, C Thomé, M Arts, Anular Closure RCT Study Group, PD Klassen

25. Joint Annual Meeting of the Swiss Society of Neurosurgery and the Swiss Society of Neuroradiology, Bern, Switzerland, 8-9 June 2017Reduction of recurrent lumbar disc herniation in high risk patients - application of a new technique. Cantonal Hospital St. Gallen, SwitzerlandM Schneider, J-Y Fournier

26. Societe de Neurochirurgie de Langue Francaise (SNCLF), 42ieme Congres, Brussels, Belgium, 22-24 May 2017Réduction des récidives de hernie discale lombaire chez les patients à haut risque - adoption d’une nouvelle technique. Hôpital Cantonal de Saint Gall, Suisse (Reduction of recurrent lumbar disc herniation in high risk patients - application of a new technique. Cantonal Hospital St. Gallen, Switzerland)M Schneider, J-Y Fournier

27. 68th Annual Meeting of the German Society of Neurosurgery (DGNC). 7th Joint Meeting With The British Neurological Surgeons (SBNS), Magdeburg, Germany, 14-17 May, 2017Early Readmission, Delayed Discharge, Reoperation After Lumbar Discectomy: An Analysis from a Multicenter, Prospective, Randomized StudyA Kursumovic, GJ Bouma, PD Klassen, C Thomé, Anular Closure RCT Study Group, F Martens

28. 68th Annual Meeting of the German Society of Neurosurgery (DGNC). 7th Joint Meeting With The British Neurological Surgeons (SBNS), Magdeburg, Germany, 14-17 May, 2017Is there a difference in early readmission and delayed discharge after lumbar discectomy in subjects with or without a bone anchored anular closure - german subanalsysis from a multicenter, prospective, randomised studyR Bostelmann, A Kursumovic, V. Heidecke, S Fröhlich, J Perrin, S Jadik, P Vajkoczy, E Van Saldern, PD Klassen

29. International Society for the Advancement for Spine Surgery (ISASS), Boca Raton, FL, 12 - 14 April, 2017Are large anular defects in primary lumbar discectomy patients a predictor of increased risk for early recurrent herniation and readmission? A comparison of prospectively collected large defect discectomy data to the literature.A Araghi; C Thomé; Anular Closure RCT Study Group, PD Klassen

30. 28th Annual Scientific Meeting of the Spine Society of Australia, 7 - 9 April, 2017Preventing symptomatic reherniation and reoperation after lumbar discectomy: Superiority data from a multi-center, prospective, randomized superiority studyA Kursumovic

31. 28th Annual Scientific Meeting of the Spine Society of Australia, Hobart, Australia, 7 - 9 April, 2017Are large anular defects in lumbar discectomy patients a predictor of increased risk for recurrent herniation, as well as early readmission?A Kursumovic

32. 16th European Congress of Neurosurgery (EANS), Athens, Greece, 4-8 September 2016Discectomy with and without Anular Closure for High-Risk Disc Herniation Patients: Complete Early Readmission and Delayed Discharge Analysis from a Multicenter, Prospective, Randomized StudyC Thome, H-P Köhler, M Arts, PD Klassen, Barricaid® Anular Closure RCT Study Group

33. 16th European Congress of Neurosurgery (EANS), Athens, Greece, 4-8 September 2016Clinical and real world experience with anular closure at a single siteA Kursumovic, S Rath

34. 67th Annual Meeting of the German Society of Neurosurgery (DGNC). 1st Joint Meeting With The Korean Neurosurgical Society (KNS). Frankfurt, Germany. 12-15 June, 2016Do trial inclusion/exclusion criteria exclude real world patients? – anular closure device (ACD) registry patients screened against trial criteria for the ACD randomized trialA Kursumovic, S Rath

35. 67th Annual Meeting of the German Society of Neurosurgery (DGNC). 1st Joint Meeting With The Korean Neurosurgical Society (KNS). Frankfurt, Germany. 12-15 June, 2016A randomized superiority study of anular closure for lumbar discectomy: The initial German experienceS Jadik, S Rath, M Barth, A Hegewald, R Bostelmann, P D Klassen

36. 27th Annual Meeting Spine Society of Australia, Melbourne, 7-10 April, 2016 A prospective, randomized clinical trial investigating an anular closure device: Interim safety analysisC Thome, GJ Bouma, R Hes, Anular Repair RCT Study Group, J Fandino

37. 27th Annual Meeting Spine Society of Australia, Melbourne, 7-10 April, 2016 Lumbar discectomy patients at high risk of reherniation: Massive defects in a primary lumbar discectomy populationC Thome, F Martens, A Kursumovic, Anular Repair RCT Study Group, PD Klassen

38. International Society for the Advancement for Spine Surgery (ISASS), Las Vegas, NV, 6-8 April, 2016 Interim Results from a Prospective, Randomized Clinical Trail Investigating an Anular Closure DeviceGJ Bouma, PD Klassen, F Martens, J. Fandino, Anular Closure RCT Study Group

39. 10th Annual Meeting of the German Spine Society (DWG), Frankfurt, Germany, 10-12 December 2015Perioperatives Sicherheitsprofil einer lumbalen Diskektomie mit und ohne Anulusverschluss: Erfahrungen aus Deutschland im Rahmen einer randomisierten klinischen StudieP Vajkoczy, A Hegewald, S Jadik, H-P Kohler, S Frohlich, PD Klassen

40. Brussels International Spine Symposium (BISS), Brussels, Belgium, 19-21 November 2015Treating Lumbar Discectomy Patients at High Risk of Reherniation: Does Anular Closure Affect Outcomes?R Assaker, PD Klassen, GJ Bouma, A Kursumovic, F Martens, J Fandino

41. Europ. Assoc. Neurological Surgeons (EANS), Madrid, Spain, 18-21 October 2015Risk factors for early reherniation after lumbar discectomy with or without anular closure: Results of a multicenter randomized controlled studyJ Kienzler, J Fandino, C Thomé, R Hes, R Bostelmann, F Martens, GJ Bouma, M Barth, P Vajkoczy, PD Klassen

42. Europ. Assoc. Neurological Surgeons (EANS), Madrid, Spain, 18-21 October 2015Perioperative Demographics, Intraoperative Findings and Complications in Lumbar Microdiscectomy: Comparison of Anular Closure to Discectomy AloneJ Kienzler, J Fandino, C Thomé, R Hes, R Bostelmann, F Martens, GJ Bouma, M Barth, P Vajkoczy, PD Klassen

43. ISASS/IITTSS September Course & Meeting, Boston, MA, 18-20 September, 2015.Barricaid Anular Closure: Clinical Need, Patient Selection and OutcomesA Kursumovic

44. 12th Annual Symposium of the Spine Technology and Educational Group Organization. Los Cabos, Mexico, 18 - 20 June, 2015Barricaid Anular ClosureS Garfin

45. 66th Annual Meeting of the German Society of Neurosurgery (DGNC). Friendship Meeting with Italian Neurosurgical Society (SINch). Karlsruhe, Germany. June 7-10, 2015Confirming the Carragee Massive-Defect Results: Lumbar Discectomy Patients at High Risk of ReherniationA Kursumović, F Martens, C Thomé, PD Klassen, J Fandino

46. 66th Annual Meeting of the German Society of Neurosurgery (DGNC). Friendship Meeting with Italian Neurosurgical Society (SINch). Karlsruhe, Germany. June 7-10, 2015Clinical and Real World Experience with Anular Closure at a Single Site A Kursumović, G Cantone, S Rath

47. International Society for the Advancement for Spine Surgery (ISASS), San Diego, CA, 15-17 April, 2015 Confirming the Carragee Massive-defect Results: Lumbar Discectomy Patients at High Risk of Reherniation GJ Bouma, A Kursumovic, J Kienzler, C Thomé, R Bostelmann

48. International Society for the Advancement for Spine Surgery (ISASS), San Diego, CA, 15-17 April, 2015 Early Readmissions Following Lumbar Discectomy with and without Anular Closure: Interim Data from an RCT J Kienzler, G Lesage, R Hes, PD Klassen, Anular Closure RCT Study Group

49. 26th Annual Scientific Meeting Spine Society of Australia, Canberra, Australia, 10-12 April, 2015 Lumbar microdiscectomy and placement of an annular closure device. Initial experience. MJ Day

50. 5th International Congress Biotechnologies for Spinal Surgery (BioSpine), Berlin, Germany, 8-11 April, 2015 Current And Possible Future Options For Anular Closure C Thomé

51. 5th International Congress Biotechnologies for Spinal Surgery (BioSpine), Berlin, Germany, 8-11 April, 2015 Principles And Biomechanical Challenges Of Anulus Sealing HJ Wilke

52. Evidence & Technology Spine Summit, North American Spine Society, Snowbird, UT, 26-28 February, 2015Initial Two-Year Safety Data for an Annular Closure Device: Interim Results from a Prospective, Multicenter, Randomized Control TrialJ Kienzler, J Fandino, F Martens, R Hes, GJ Bouma, Anular Closure RCT Study Group, PD Klassen

53. Congress of Neurological Surgeons (CNS), Boston, USA, 18-22 October 2014Discectomy Patients at High Risk of Reherniation: Confirming the Carragee Large-Defect ResultsGJ Bouma, PD Klassen, J Fandino, F Martens, R Hes

54. Congress of Neurological Surgeons (CNS), Boston, USA, 18-22 October 2014Early Two-Year Safety Data for an Anular Closure Device: Interim Results from a Multicenter, Prospective, Randomized Clinical TrialJ Kienzler, J Fandino, F Martens, R Hes, GJ Bouma, Anular Closure RCT Study Group, PD Klassen

55. Europ. Assoc. Neurological Surgeons (EANS), Prague, Czech Republic, 13-16 October 2014The Barricaid annular prosthesis: Two-year clinical data and interim safety results of a multicenter RCTGJ Bouma

56. DGNC Spine Section, Innsbruck, Austria, 19-20 September 2014Reoperation rate and revision strategies of failed lumbar discectomy with and without anular closureC Thomé, GJ Bouma, F Martens, J Fandino, PD Klassen

57. DGNC Spine Section, Innsbruck, Austria, 19-20 September 2014Endplate changes observed on CT following lumbar discectomy: Interim analysis from the discectomy-only cohort of a post-marketing, multicenter, prospective studyM Barth, C Thomé, PD Klassen, J Fandino

58. DGNC Spine Section, Innsbruck, Austria, 19-20 September 2014Führen große Anulusdefekte zu höherem Risiko für Rezidiv-Bandscheibenvorfälle bei Patienten nach lumbaler Diskektomie?A Kursumovic, F Martens, GJ Bouma, C Thome, PD Klassen, J Fandino

59. National Congress of the Society of Spine Surgery SICV & GIS. Milan, Italy. 15 - 17 May 2014 24 Month Safety Data from a Prospective, Randomized Clinical Trial Evaluating an Anular Closure DeviceR Hes, PD Klassen, F Martens, GJ Bouma, A Kuršumović, Anular Closure RCT Study Group

60. German Society of Neurosurgery Annual Meeting. Dresden, Germany. 11-14 May, 2014Bone-Anchored Anular Closure Device Following Limited Discectomy For Primary Lumbar Disc Herniation: Biomechanical Testing, Surgical Technique, And Preliminary Clinical ResultsNG Rainov, J Einhorn, V Heidecke

61. 1st EUROSPINE Spring Speciality Meeting. Prague, Czech Republic. 8-9 May 201424 Month Safety Data From A Prospective, Randomized Clinical Trial Evaluating An Anular Closure Device: An Interim Review A Kuršumović, PD Klassen, F Martens, R Hes, Anular Closure RCT Study Group, GJ Bouma

62. Spine Society of Australia Annual Scientific Meeting. Brisbane, Australia. 10-12 April 201424 Month Safety Data from a Prospective, Randomized Clinical Trial Evaluating an Anular Closure Device: An Interim ReviewA Kuršumović, PD Klassen, F Martens, R Hes, Anular Closure RCT Study Group, GJ Bouma

63. Neurosurgery in the Rockies. Colorado, USA. 23-27 February 2014Initial Two-Year Safety Data for an Anular Closure Device: Interim Results from a Multicenter, Prospective, Randomized Clinical TrialPD Klassen, F Martens, R Hes, GJ Bouma, A Kuršumović, Anular Closure RCT Study Group 6

64. 19. Forum Wirbelsäulenchirurgie. St. Anton am Arlberg, Austria, January 16-18, 2014Darf’s Ein Bisschen Mehr Sein? (Anulusverschluss U.Ä)PD Klassen

65. 3. Wirbelsäulenschmerzkongress. Munich, Germany. November 23, 2013 Rezidivbandschreibenvorfall, Kann Man Ihn Verhindern? (Reherniation, Can It Be Avoided?)M Trummer

66. Looking at the Future of the Spine Surgery based on the past experience. Venice, Italy. November 7-9, 2013Closing The Anulus After Lumbar Discectomy: Indications, Technique And Results With Barricaid® Bone Anchored Prosthesis S Eustacchio

67. 62° Congresso Nazionale Società Italiana Neurochirurgia (SINch). Palermo, Italy. October 10-12, 2013 Anular Closure Device: A Real World ExperienceA Kuršumović, S Rath

68. 62° Congresso Nazionale Società Italiana Neurochirurgia (SINch). Palermo, Italy. October 10-12, 2013 Utilizzo Di Una Protesi Anulare Discale Come Complemento Intraoperatorio Del Trattamento Chirurgico Dell’ernia Discale Lombare: Risultati PreliminariF Barone, N Alberio, M Fricia, M Passanisi, P Seminara (Catania)

69. 64th Annual Meeting of the German Society of Neurosurgery (DGNC). Friendship Meeting with Chinese Neurosurgical Society (CNS). Düsseldorf, Germany. May 26-28, 2013.How Does Intradiscal Pressures Respond To Annulotomy And Annular Closure? – An In Vitro Biomechanical Study Of The Lumbar Functional Spinal Unit (Fsu) R Bostelmann, JF Cornelius, HJ Steiger, M Leimert

70. 64th Annual Meeting of the German Society of Neurosurgery (DGNC). Friendship Meeting with Chinese Neurosurgical Society (CNS). Düsseldorf, Germany. May 26-28, 2013. A Multicenter, Prospective, Randomized Study To Demonstrate The Superiority Of A Bone-Anchored Prosthesis For Annular Closure Used In Conjunction With Limited Discectomy To Limited Discectomy Alon For Primary Lumbar Disc HerniationPD Klassen, R Hes, GJ Bouma, S Eustacchio, M Barth, S Rath, H M Mehdorn, V Heidecke, R Bostelmann, C Thomé, P Vajkoczy, HP Köhler, F Martens

71. 64th Annual Meeting of the German Society of Neurosurgery (DGNC). Friendship Meeting with Chinese Neurosurgical Society (CNS). Düsseldorf, Germany. May 26-28, 2013. Three Years Experience With An Anular Closure DeviceA Kuršumović, S Rath

72. Congresso Nazionale Società Italiana Di Chirurgia Vertebrale E Gruppo Italiano Scoliosi (GIS). May 16-18. Bologna, ItalyLumbar Discectomy With An Anular Closure Prosthesis: Two-Year Clinical And Radiographic Results From A Prospective, Multicenter Study S Eustacchio, M Barth, GJ Bouma

73. Congresso Nazionale Società Italiana Di Chirurgia Vertebrale E Gruppo Italiano Scoliosi (GIS). May 16-18. Bologna, Italy Effect of Annular Defects on Intradiscal Pressures in the Lumbar Spine - An In Vitro Biomechanical Study of Discectomy and Annular Closure R Bostelmann, JF Cornelius, TM Kinfe, HJ Steiger, M Leimert

74. ISASS. Vancouver, Canada. April 2-5, 2013Comparative Effectiveness and Cost-utility of a Novel Annular Closure Device for Prevention of Recurrent Disc Herniation Following Lumbar Discectomy: A Prospective Cohort StudySL Parker, G Grahovac, D Vukas, D Ledic, M Vilendecic, MJ McGirt

75. DWG 2012. Stuttgart, Germany. December 6-8, 2012 Limited Lumbar Discectomy with an Anular Closure Device: Initial 24 Month Clinical and Radiographic Results from a Prospective, Multinational, Multi-Center StudyPD Klassen, C Thomé, GJ Bouma, M Barth

76. DWG 2012. Stuttgart, Germany. December 6-8, 2012Disc preservation after discectomy and anular closure: investigation of modic changes M Barth, M Vilendecic, D Ledic, GJ Bouma

77. DWG 2012. Stuttgart, Germany. December 6-8, 2012Bandscheibenschonung durch Annulusverschluss – Radiografische Veränderungen nach DiskektomieM Trummer, M Vilendecic, D Ledic, GJ Bouma, M Barth (Mannheim), S Eustacchio

78. DWG 2012. Stuttgart, Germany. December 6-8, 2012Effect of Annular Defects on Intradiscal Pressures in the Lumbar Spine - An In Vitro Biomechanical Study of Discectomy and Annular ClosureR Bostelmann, J.F Cornelius, H-J Steiger, M Leimert

79. ÖGNC. Graz, Austria; October 4-6, 2012Two-Year Benefits of Anular Defect Closure After Limited DiscectomyPD Klassen, C Thome, GJ Bouma, T Marinovic, D Ledic, M Barth

80. ÖGNC. Graz, Austria; October 4-6, 2012Real World Experience with an Anular Closure DeviceA Kuršumović, S Rath

81. ÖGNC. Graz, Austria; October 4-6, 2012Cost Effectiveness of Anular Closure: Same-Site Comparison to a Primary Discectomy PopulationS Eustacchio, D Ledic, T Marinovic

82. DGNC-Spine Section. Köln, Germany; September 14-15, 2012Kommt es zur Veränderung des intradiskalen Druckes nach Diskektomie und nach Anulusverschluß? - Eine in vitro biomechanische UntersuchungR Bostelmann, JF Cornelius, HJ Steiger, M Leimert

83. DGNC-Spine Section. Köln, Germany; September 14-15, 2012Do Trial Inclusion/Exclusion Criteria Exclude Real World Patients? – Anular Closure Device (Acd) Registry Patients Screened Against Trial Criteria For The ACD Randomized TrialA Kuršumović, S Rath

84. 63rd Annual Meeting of the German Society of Neurosurgery (DGNC). Joint Meeting with the Japanese Neurosurgical Society (JNS). Leipzig, Germany. June 13-16, 2012.Preventing Facet Degeneration After Discectomy With An Anular Closure DeviceM Vilendecic, D Ledic, GJ Bouma, M Barth, S Eustacchio, S Stein

85. 63rd Annual Meeting of the German Society of Neurosurgery (DGNC). Joint Meeting with the Japanese Neurosurgical Society (JNS). Leipzig, Germany. June 13-16, 2012.Would You Ride Your Bicycle With A Puncture In The Tire? Two-Year Benefits Of Anular Defect Closure After Lumbar DiscectomyGJ Bouma, M Barth, M Vilendecic, D Ledic, R Bartels, EA Al-Kahlout

86. 63rd Annual Meeting of the German Society of Neurosurgery (DGNC). Joint Meeting with the Japanese Neurosurgical Society (JNS). Leipzig, Germany. June 13-16, 2012.Real World Experience With An Anular Closure DeviceA Kuršumović, S Rath

87. 63rd Annual Meeting of the German Society of Neurosurgery (DGNC). Joint Meeting with the Japanese Neurosurgical Society (JNS). Leipzig, Germany. June 13-16, 2012.Can Lumbar Discectomy With The Barricaid Endoprosthesis Bring Benefit To Patients With Back Pain Greater Than Leg Pain?GJ Bouma, M Barth, M Vilendecic, D Ledic, R Bartels, EA Al-Kahlout

88. Britspine Meeting, Newcastle, United Kingdom. May 2–4, 2012.Preventing Reherniations With An Anular Closure EndoprosthesisGJ Bouma, M Barth, M Vilendecic, D Ledic, R Bartels, E Al-Kahlout

89. 6th German Spine Conference, Annual Meeting of the German Spine Society. Hamburg, Germany. December 8-10, 2011.Preventing Disc Height Loss And Reherniation After Discectomy: One-Year Data From An EU Post-Marketing Study Of An Anular Closure TechnologyGJ Bouma, M. Barth, R. Bartels, E. Al-Kahlout, M. Vilendecic, M. Gorensk, P. Varga, D. Ledic, S. Eustacchio

90. North American Spine Society, 26th Annual Meeting. Chicago, IL. November 2-5, 2011.The Spine Journal Vol. 11, Issue 10, Supplement, Pages S148-S149:Can Herniation Be Prevented? Establishment of a Herniation Model and Experiments with an Annulus Reconstruction ImplantHJ Wilke, L Widmann, N Graf, F Heuer

91. EuroSpine 2011. Milan, Italy. October 19-21, 2011.Preventing Disc Height Loss and Reherniation After Discectomy: One-Year Data From an EU Post-Marketing Study of an Anular Closure TechnologyGJ Bouma, M Barth, RH Bartels, T Beems, E Al-Kahlout, M Vilendecic, M Gorensek, P Varga, D Ledic, S Eustacchio

92. Spine Arthroplasty Society, 11th Annual Meeting. Las Vegas, NV. April 26-29, 2011.Reconstructing the Anulus: Complete One-Year and Initial Two-Year Results From the IntrinsicTherapeutics Barricaid Endoprosthesis Pilot StudyM Vilendecic, D Ledic, G Grahovac, D Vukas, P Varga, S Eustacchio, M Gorensek

93. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, 27th Annual Meeting.Phoenix, AZ. March 9-12, 2011.Effect of a Novel Anular Repair Device (Barricaid) on Same Level Recurrent Disc Herniation and Disc Height Loss After Primary Lumbar Discectomy: Results of a Multicenter Non-randomized Prospective Cohort StudyS Parker, KL Chaichana, D Ledic, M Vilendecic, MJ McGirt

94. DWG 2010. Bremen, Germany. December 16-18, 2010. V33 Eur Spine J (2010) 19:1976:An annulus fibrosus prosthesis. EU clinical (phase II) study: One-year results in reconstructing the anulusS Eustacchio, M Trummer, M Vilendecic, D Ledic, P Varga, M Gorensek, W Kreil, H Schröttner

95. DWG 2010. Bremen, Germany. December 16-18, 2010. SP12 Eur Spine J (2010) 19:1995-1996:Biomechanical investigation of a new annulus reconstruction implant after a provoked nucleus extrusionH-J Wilke, L Widmann, N Graf, F Heuer

96. DWG 2010. Bremen, Germany. December 16-18, 2010. P47 Eur Spine J (2010) 19: 2016:Effectiveness And Safety Of A New Designed Endodiscal Device In The Treatment Of Primary Lumbar Discectomy: Results Of A Prospective Study In 20 PatientsPD Klassen, B Baume, H Seidel

97. DWG 2010. Bremen, Germany. December 16-18, 2010. P142 Eur Spine J (2010) 19: 2051-2052:Design History of an Anular Reconstruction Device: From Failure to SuccessM Trummer, S Eustacchio

98. DWG 2010. Bremen, Germany. December 16-18, 2010. P154 Eur Spine J (2010) 19: 2056:Initial Clinical Results Concerning Reherniation with Novel Anular Closure Device ‘Barricaid’ after Limited Discectomy for Patients with Lumbar Disc HerniationA Kuršumović, S Rath

99. DWG 2010. Bremen, Germany. December 16-18, 2010. P161 Eur Spine J (2010) 19:1963:Short-Term Results Of A Novel Bone-Anchored Anular Closure Device In Lumbar Disc SurgeryC Thomé, R Bartels, M Barth, E Al-Kahlout, GJ Bouma

DEFINING THE NEED (DISCECTOMY OUTCOMES ARE NOT PERFECT)100. J Bone Joint Surg Am. (2003) Jan;85-A(1):102-8.

Clinical Outcomes After Lumbar Discectomy for Sciatica: The Effects of Fragment Type and Anular Comptence.Carragee, et al.

101. Spine (2006) Mar 15;31(6):653-7. A Prospective Controlled Study Of Limited Versus Subtotal Posterior Discectomy: Short-Term Outcomes In Patients With Herniated Lumbar Intervertebral Discs And Large Posterior Anular Defect.Carragee, et al.

102. Spine (2000) Jun 15;25(12):1500-8. Reoperations After Lumbar Disc Surgery: A Population-Based Study Of Regional And Interspecialty Variations.Keskimäki , et al.

103. Spine J. (2012) Feb;12(2):89-97. doi: 10.1016/j.spinee.2011.11.010. Epub 2011 Dec 21. Repeat Surgery After Lumbar Decompression For Herniated Disc: The Quality Implications Of Hospital And Surgeon Variation.Martin, et al.

104. Spine (2007) Feb 1;32(3):382-7.Reoperation Rates Following Lumbar Spine Surgery And The Influence Of Spinal Fusion Procedures.Martin, et al.

105. Neurosurgery (2009) Feb;64(2):338-44; discussion 344-5.Recurrent Disc Herniation And Long-Term Back Pain After Primary Lumbar Discectomy: Review Of Outcomes Reported For Limited Versus Aggressive Disc Removal.McGirt, et al.

106. Spine (2003) Mar 15;28(6):621-7.Risk Of Multiple Reoperations After Lumbar Discectomy: A Population-Based Study.Osterman, et al.

107. Eur Spine J. (2009) Aug;18 Suppl 3:294-304.The Swedish Spine Register: development, design and utility.Strömqvist, et al.

108. Spine J. (2009) Mar;9(3):240-57. 46.An Evidence-Based Review Of The Literature On The Consequences Of Conservative Versus Aggressive Discectomy For The Treatment Of Primary Disc Herniation With Radiculopathy.Watters, et al.

109. Spine (2013) Feb 7. [Epub ahead of print]Prospective, Multi-Center, Randomized, Controlled Study of Anular Repair in Lumbar Discectomy: Two-Year Follow-Up.Bailey, et al.

110. Spine 2(013) Apr;38(7): 581–590Reoperation Rate After Surgery For Lumbar Herniated Intervertebral Disc Disease: Nation-Wide Cohort Study.Kim, et al.

111. Eur Spine J, DOI 10.1007/s00586-014-3734-8Endplate Changes Following Discectomy: Natural History And Associations Between Imaging And Clinical Data.Weiner, et al.

112. J Spinal Disord Tech Volume 28, Number 10, December 2015Preoperative Risk Factors for Recurrent Lumbar DiskHerniation in L5–S1Kim, et al.

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UPDATE: August 2017