SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-81 07 1981-03 -12 2003-16 09 09 09

White 1975-03 -09 2003-16 12 12 12

Black 1975-84 22 1984-16 -23 -23 -23

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-05 -02 2005-16 09 09 09

White 2000-03 -04 2003-16 12 12 12

White NHef 2000-05 04 2005-16 16 16 16

Black 2000-16 -16 -16 -16

Black NHef 2000-16 -16 -16 -16

APIe 2000-07 -16 2007-16 12 12 12

AIANeg 2000-16 13 13 13

Hispanicf 2000-16 -01 -01 -01

US Cancer Mortalityc 1975-2016

All Races 1975-79 -05 1979-93 -17 1993-00 -27 2000-09 -14 2009-16 08 03 08

White 1975-06 -19 2006-16 07 07 07

Black 1975-80 33 1980-93 -15 1993-09 -40 2009-16 -13 -19 -13

US Cancer Mortalityc 2000-2016

All Races 2000-09 -14 2009-16 08 03 08

White 2000-09 -09 2009-16 12 07 12

White NHef 2000-09 -08 2009-16 13 08 13

Black 2000-16 -28 -28 -28

Black NHef 2000-16 -27 -27 -27

APIe 2000-09 -30 2009-16 16 06 16

AIANeg 2000-16 -05 -05 -05

Hispanicf 2000-16 -08 -08 -08

Table 201

Cancer of the Oral Cavity and Pharynx (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Both Sexes by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpoint over the time range of 1975-2016 The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd Years APC Years APC Years APC Years APC Years APC Years APC 2012-16

Cancer of the Tongue

All Races Both Sexes 1975-99 04 1999-16 22 22All Races Male 1975-99 04 1999-16 25 25All Races Female 1975-10 05 2010-16 38 38White Male 1975-98 05 1998-16 30 30White Female 1975-99 03 1999-16 17 17Black Male 1975-89 11 1989-16 -25 -25Black Female 1975-16 -15 -15

Cancer of the Floor of Mouth Gum and Other MouthAll Races Both Sexes 1975-87 -11 1987-16 -39 -39All Races Male 1975-87 -14 1987-16 -40 -40All Races Female 1975-80 47 1980-16 -34 -34White Male 1975-16 -32 -32White Female 1975-82 19 1982-16 -33 -33Black Male 1975-77 562 1977-93 -26 1993-16 -68 -68Black Female - - -

Cancer of the Oropharynx and TonsilAll Races Both Sexes 1975-99 00 1999-14 31 2014-16 -31 00All Races Male 1975-97 03 1997-16 30 30All Races Female 1975-00 -15 2000-16 12 12White Male 1975-96 03 1996-16 37 37White Female 1975-00 -13 2000-16 17 17Black Male 1975-16 -06 -06Black Female 1975-16 -15 -15

Cancer of the Salivary GlandAll Races Both Sexes 1975-16 05 05All Races Male 1975-16 05 05All Races Female 1975-16 04 04White Male 1975-16 05 05White Female 1975-16 03 03Black Male 1975-96 33 1996-10 -42 2010-16 124 124Black Female 1975-16 08 08

Cancer of the LipAll Races Both Sexes 1975-99 -32 1999-08 -59 2008-16 16 16All Races Male 1975-96 -37 1996-09 -60 2009-16 12 12All Races Female 1975-96 02 1996-11 -23 2011-16 72 72White Male 1975-96 -34 1996-09 -59 2009-16 12 12White Female 1975-16 -03 -03Black Male - - -Black Female - - -

Table 202Cancer of the Oral Cavity and Pharynx for Selected Subsites (Invasive)

Trends in SEER 9 Observed Incidencea Using the Joinpoint Regression Program1975-2016 With up to Five Joinpoints

By Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-83 -02 1983-03 -14 2003-16 10 10 10

White 1975-03 -12 2003-16 14 14 14

Black 1975-86 20 1986-16 -27 -27 -27

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-05 -02 2005-16 10 10 10

White 2000-16 11 11 11

White NHef 2000-16 15 15 15

Black 2000-16 -21 -21 -21

Black NHef 2000-16 -20 -20 -20

APIe 2000-16 04 04 04

AIANeg 2000-16 13 13 13

Hispanicf 2000-16 -04 -04 -04

US Cancer Mortalityc 1975-2016

All Races 1975-93 -19 1993-00 -30 2000-09 -12 2009-16 10 05 10

White 1975-05 -21 2005-16 09 09 09

Black 1975-80 37 1980-92 -14 1992-08 -40 2008-16 -22 -24 -22

US Cancer Mortalityc 2000-2016

All Races 2000-09 -13 2009-16 10 05 10

White 2000-09 -08 2009-16 15 10 15

White NHef 2000-09 -06 2009-16 16 11 16

Black 2000-16 -31 -31 -31

Black NHef 2000-16 -30 -30 -30

APIe 2000-10 -27 2010-16 26 08 26

AIANeg 2000-16 00 00 00

Hispanicf 2000-08 -28 2008-16 03 -01 03

Table 203

Cancer of the Oral Cavity and Pharynx (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Males by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-80 25 1980-07 -09 2007-16 09 09 09

White 1975-81 20 1981-05 -09 2005-16 08 08 08

Black 1975-16 -15 -15 -15

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-16 03 03 03

White 2000-16 05 05 05

White NHef 2000-16 07 07 07

Black 2000-16 -09 -09 -09

Black NHef 2000-16 -09 -09 -09

APIe 2000-16 -02 -02 -02

AIANeg 2000-16 06 06 06

Hispanicf 2000-16 03 03 03

US Cancer Mortalityc 1975-2016

All Races 1975-90 -09 1990-04 -24 2004-14 -12 2014-16 48 01 17

White 1975-90 -10 1990-03 -23 2003-14 -11 2014-16 53 03 21

Black 1975-94 -06 1994-05 -46 2005-16 -14 -14 -14

US Cancer Mortalityc 2000-2016

All Races 2000-14 -14 2014-16 53 00 19

White 2000-14 -13 2014-16 57 02 22

White NHef 2000-14 -12 2014-16 58 03 23

Black 2000-16 -21 -21 -21

Black NHef 2000-16 -20 -20 -20

APIe 2000-16 -12 -12 -12

AIANeg 2000-16 -27 -27 -27

Hispanicf 2000-16 -03 -03 -03

Table 204

Cancer of the Oral Cavity and Pharynx (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Females by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-1979 1333 2102 743 1321 2100 733 1551 2444 8461980 1334 2025 791 1298 1996 762 1682 2539 9591981 1358 2084 791 1341 2053 795 1660 2816 7361982 1334 2032 793 1308 1994 785 1706 2739 8751983 1328 2120 724 1325 2121 728 1613 2608 8321984 1347 2079 786 1300 2016 764 1891 2999 10071985 1333 1982 824 1328 1962 836 1598 2582 8411986 1247 1914 720 1236 1886 730 1618 2809 6971987 1321 2054 752 1311 2017 768 1681 3000 6991988 1214 1815 732 1179 1769 711 1654 2567 9191989 1213 1831 729 1185 1772 732 1575 2716 7051990 1267 1942 735 1240 1884 739 1605 2789 6921991 1216 1834 725 1208 1809 732 1456 2393 7411992 1197 1834 692 1182 1805 693 1485 2521 6941993 1242 1870 729 1220 1835 721 1564 2506 8101994 1172 1769 684 1141 1687 692 1574 2682 7071995 1154 1695 720 1152 1673 734 1358 2271 6661996 1178 1777 698 1147 1727 685 1512 2444 7811997 1151 1736 674 1152 1721 685 1158 1855 6181998 1124 1668 677 1124 1637 695 1320 2261 6421999 1059 1556 648 1048 1542 635 1195 2027 5832000 1076 1608 631 1067 1566 641 1175 2076 4932001 1085 1556 692 1092 1562 695 1211 1903 7012002 1113 1634 674 1131 1658 680 1115 1695 6552003 1053 1565 619 1049 1564 604 1189 1722 7662004 1085 1615 629 1109 1652 631 1026 1618 5892005 1074 1567 653 1089 1605 640 1119 1673 7062006 1080 1587 643 1105 1610 661 1014 1670 5242007 1084 1611 628 1113 1655 630 1017 1578 5892008 1104 1641 643 1149 1695 666 888 1402 4972009 1108 1643 640 1133 1678 646 1069 1627 6392010 1099 1636 625 1145 1694 646 880 1329 5252011 1135 1685 656 1199 1776 681 911 1435 5112012 1125 1642 672 1181 1720 693 863 1427 4262013 1157 1735 654 1211 1820 668 965 1499 5552014 1155 1764 619 1212 1842 640 937 1548 4732015 1193 1766 693 1263 1882 705 902 1405 5392016 1198 1768 695 1264 1866 712 864 1326 516

Table 205Cancer of the Oral Cavity and Pharynx (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2016 1183 1778 691 1196 1794 697 1218 1961 6451975-1979 1333 2102 743 1321 2100 733 1551 2444 8461980 1334 2025 791 1298 1996 762 1682 2539 9591981 1358 2084 791 1341 2053 795 1660 2816 7361982 1334 2032 793 1308 1994 785 1706 2739 8751983 1328 2120 724 1325 2121 728 1613 2608 8321984 1347 2079 786 1300 2016 764 1891 2999 10071985 1333 1982 824 1328 1962 836 1598 2582 8411986 1247 1914 720 1236 1886 730 1618 2809 6971987 1321 2054 752 1311 2017 768 1681 3000 6991988 1214 1815 732 1179 1769 711 1654 2567 9191989 1213 1831 729 1185 1772 732 1575 2716 7051990 1267 1942 735 1240 1884 739 1605 2789 6921991 1216 1834 725 1208 1809 732 1456 2393 7411992 1197 1834 692 1182 1805 693 1485 2521 6941993 1242 1870 729 1220 1835 721 1564 2506 8101994 1172 1769 684 1141 1687 692 1574 2682 7071995 1154 1695 720 1152 1673 734 1358 2271 6661996 1178 1777 698 1147 1727 685 1512 2444 7811997 1151 1736 674 1152 1721 685 1158 1855 6181998 1124 1668 677 1124 1637 695 1320 2261 6421999 1059 1556 648 1048 1542 635 1195 2027 5832000 1076 1608 631 1067 1566 641 1175 2076 4932001 1085 1556 692 1092 1562 695 1211 1903 7012002 1113 1634 674 1131 1658 680 1115 1695 6552003 1053 1565 619 1049 1564 604 1189 1722 7662004 1085 1615 629 1109 1652 631 1026 1618 5892005 1074 1567 653 1089 1605 640 1119 1673 7062006 1080 1587 643 1105 1610 661 1014 1670 5242007 1084 1611 628 1113 1655 630 1017 1578 5892008 1103 1639 642 1147 1693 665 886 1400 4962009 1106 1640 638 1130 1673 644 1066 1622 6362010 1096 1631 624 1141 1688 644 875 1322 5222011 1131 1679 653 1193 1767 677 905 1426 5072012 1120 1634 669 1174 1709 689 855 1415 4232013 1150 1726 651 1202 1807 663 956 1484 5492014 1146 1750 614 1200 1823 633 925 1525 4682015 1181 1748 686 1245 1855 695 886 1380 5302016 1176 1736 682 1233 1821 694 840 1290 501

Table 206Cancer of the Oral Cavity and Pharynx (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2016 307 475 173 293 448 171 433 754 1951975-1979 425 687 230 405 650 225 618 1071 2691980 416 669 227 387 612 222 697 1248 2761981 405 646 224 378 596 217 652 1136 2841982 402 646 222 374 596 213 662 1146 2941983 394 627 220 364 573 210 665 1183 2761984 388 618 217 361 564 212 637 1170 2381985 375 593 211 349 544 205 623 1103 2621986 372 580 216 342 527 207 651 1135 2931987 353 546 205 329 501 200 570 995 2541988 359 563 205 333 514 198 599 1067 2551989 350 534 207 323 484 200 592 1044 2591990 358 561 203 329 507 196 612 1105 2521991 347 534 203 321 487 195 584 1006 2701992 334 515 194 309 466 189 556 997 2311993 334 519 190 307 468 183 568 1009 2441994 315 484 183 292 441 177 533 926 2391995 316 487 184 291 442 175 537 928 2541996 303 464 175 282 424 171 486 869 2071997 298 453 176 279 417 170 468 810 2191998 296 453 172 280 420 168 453 791 2091999 273 415 160 255 380 154 437 749 2122000 269 406 158 252 372 155 412 730 1762001 272 415 156 258 387 153 386 665 1802002 268 408 155 257 387 151 365 626 1732003 264 407 148 251 380 145 383 686 1652004 261 399 148 249 372 146 381 684 1622005 253 384 144 242 359 144 349 642 1372006 248 378 140 239 360 138 322 557 1492007 252 385 143 245 370 141 327 560 1592008 245 374 139 240 361 138 298 504 1472009 237 364 131 233 353 132 280 497 1222010 247 375 140 245 368 140 279 476 1362011 247 386 131 242 374 130 306 536 1372012 249 386 135 246 377 135 288 504 1322013 241 372 130 239 366 129 281 477 1372014 251 397 128 250 391 130 279 487 1282015 253 392 136 253 391 135 257 412 1392016 259 398 141 260 396 143 263 450 124

Table 207Cancer of the Oral Cavity and Pharynx (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2012-2016All ages 113 170 64 119 179 66 86 134 50Under 65 67 100 36 70 104 36 56 83 3465 and over 430 655 254 457 694 269 292 485 163

All ages (WHO world std)c 89 133 49 93 140 50 69 107 40

Age-Specific Rates 2012-2016lt1 - - - - - - - - -1-4 - - - - - - - - -5-9 01 01 01 01 - - - - -10-14 03 03 03 03 02 03 - - -15-19 05 05 05 04 04 04 05 06 -20-24 06 06 06 06 06 06 06 06 0525-29 11 11 11 10 10 11 09 09 0930-34 18 20 17 17 19 15 13 11 1535-39 29 34 24 26 31 22 22 23 2140-44 56 79 34 55 76 33 43 58 3045-49 115 168 62 117 173 60 98 141 6150-54 198 299 100 209 316 102 168 251 9555-59 294 461 137 314 493 140 244 370 13660-64 359 567 169 381 599 176 303 495 14965-69 405 635 202 431 670 214 308 530 13970-74 436 673 238 464 708 254 309 526 15675-79 445 664 276 476 705 294 298 491 17580-84 445 661 296 472 702 310 286 445 19985+ 428 644 316 453 686 332 217 335 168

US MortalityAge at DeathAge-Adjusted Rates 2012-2016All ages 25 39 13 25 38 13 27 47 13Under 65 11 18 05 11 17 05 14 23 0765 and over 121 187 71 123 187 73 119 212 58

All ages (WHO world std)c 16 26 08 16 25 08 19 32 09

Age-Specific Rates 2012-2016lt1 - - - - - - - - -1-4 - - - - - - - - -5-9 - - - - - - - - -10-14 - - - - - - - - -15-19 00 - - - - - - - -20-24 00 01 - 00 00 - 01 02 -25-29 01 01 01 01 01 01 01 - -30-34 02 02 01 02 02 01 02 03 -35-39 03 04 02 03 04 02 03 04 0240-44 06 09 04 06 08 03 07 11 0445-49 16 24 08 15 22 08 23 36 1250-54 33 51 16 32 50 15 42 65 2355-59 54 86 23 53 85 22 66 107 3160-64 74 123 30 74 121 29 92 161 3565-69 89 144 39 90 144 40 102 185 3870-74 103 162 53 102 158 54 129 235 5375-79 123 191 70 126 192 71 119 203 6480-84 150 225 97 153 226 101 129 236 7085+ 195 281 150 202 290 156 125 211 89

Table 208Cancer of the Oral Cavity and Pharynx (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Stage distribution was not calculated for this site due to inconsistent coding of stage over timed Percents may not sum to 100 due to roundinge Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouthc Tonsilc Hypopharc Gland Nasopharc Pharynxc

SEER IncidenceStage Distribution 2012-2016Percent of Totald

Localized 31 83 33 43 - - - 47 - -Regional 46 5 48 44 - - - 28 - -Distant 18 1 15 8 - - - 19 - -UnstagedUnknown 6 10 4 4 - - - 7 - -

Age-Adjusted Rates 2012-2016Age at DiagnosisAll ages 113 06 35 05 15 24 06 13 06 03Under 65 67 03 21 03 07 18 03 07 05 0165+ 430 31 129 19 75 69 25 56 15 11

All ages(WHO world std)e 89 04 27 04 11 20 04 10 05 02

SexMale 170 10 52 07 19 42 10 17 09 04Female 64 03 19 03 13 09 02 10 04 01

RaceWhite 119 07 38 05 16 27 06 13 04 03Black 86 01 20 04 13 21 08 11 07 02Other 95 03 24 03 15 10 04 12 23 01

US MortalityAge-Adjusted Rates 2012-2016Age at DeathAll ages 25 00 06 00 04 05 01 03 02 04Under 65 11 00 03 00 01 03 00 01 01 0265+ 121 01 30 01 20 22 04 15 07 21

All ages(WHO world std)e 18 00 05 00 02 04 01 02 01 03

SexMale 39 00 10 00 05 08 02 04 03 07Female 13 00 04 00 03 02 00 02 01 02

RaceWhite 25 00 07 00 04 05 01 03 01 04Black 27 - 05 00 03 06 02 02 02 06Other 19 - 04 - 03 02 01 01 07 02

Table 209Cancer of the Oral Cavity and Pharynx by Subsite (Invasive)

SEER Incidencea Stage Distribution by SiteAge-Adjusted SEER Incidencea and US Deathb Rates by Age Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2016 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2016

d Period survival provides a 2015 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2009-2015 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 45 - - - - -1970-1973a - - - 43 - - - - -1975-1977b 525 516 548 541 538 547 360 297 4901978-1980b 533 518 565 554 545 574 349 298 4581981-1983b 517 501 551 540 528 565 309 254 4561984-1986b 541 517 590 563 548 594 350 295 4911987-1989b 536 510 588 560 541 598 340 300 4401990-1992b 554 532 601 579 564 610 331 284 4601993-1995b 577 562 606 601 594 613 380 331 5051996-1998b 578 562 610 599 591 614 364 313 4951999-2001b 603 592 625 622 620 627 446 396 5712002-2004b 639 631 657 657 657 657 482 428 5882005-2008b 655 651 665 674 672 679 430 407 4802009-2015b 684f 676f 704f 703f 699f 714f 509f 492f 544

5-Year Period Survival (Percent)cd

2015 658 652 674 672 668 682 493 483 515

Stage Distribution () 2009-2015ce

All StagesNumber of cases 57854 41585 16269 47354 34485 12869 5169 3580 1589Percent 100 100 100 100 100 100 100 100 100Localized 29 24 41 30 25 43 19 14 29Regional 47 51 37 48 52 38 48 51 40Distant 20 21 16 18 20 15 30 32 27UnstagedUnknown 4 4 5 4 4 5 3 3 4

5-Year Relative Survival (Percent) 2009-2015c

Age at DiagnosisAges lt45 798 773 839 811 788 849 709 671 757Ages 45-54 702 697 718 728 725 740 500 493 520Ages 55-64 666 656 703 686 675 726 465 459 483Ages 65-74 624 608 665 639 626 673 431 400 498Ages 75+ 512 511 512 521 525 512 327 301 350Ages lt65 697 684 738 716 704 755 514 497 557Ages 65+ 579 575 586 590 590 589 401 378 435

StageeAll Stages 653 646 671 667 664 677 484 467 520Localized 844 832 863 845 836 858 781 738 827Regional 660 672 617 674 688 621 496 500 482Distant 391 399 366 402 412 365 283 290 265UnstagedUnknown 509 511 503 483 487 475 402 453g 322g

Table 2010Cancer of the Oral Cavity and Pharynx (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Stage distribution was not calculated for this site due to inconsistent coding of stage over timed Percents may not sum to 100 due to roundinge Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouthc Tonsilc Hypopharc Gland Nasopharc Pharynxc

SEER IncidenceStage Distribution 2012-2016Percent of Totald

Localized 31 83 33 43 - - - 47 - -Regional 46 5 48 44 - - - 28 - -Distant 18 1 15 8 - - - 19 - -UnstagedUnknown 6 10 4 4 - - - 7 - -

Age-Adjusted Rates 2012-2016Age at DiagnosisAll ages 113 06 35 05 15 24 06 13 06 03Under 65 67 03 21 03 07 18 03 07 05 0165+ 430 31 129 19 75 69 25 56 15 11

All ages(WHO world std)e 89 04 27 04 11 20 04 10 05 02

SexMale 170 10 52 07 19 42 10 17 09 04Female 64 03 19 03 13 09 02 10 04 01

RaceWhite 119 07 38 05 16 27 06 13 04 03Black 86 01 20 04 13 21 08 11 07 02Other 95 03 24 03 15 10 04 12 23 01

US MortalityAge-Adjusted Rates 2012-2016Age at DeathAll ages 25 00 06 00 04 05 01 03 02 04Under 65 11 00 03 00 01 03 00 01 01 0265+ 121 01 30 01 20 22 04 15 07 21

All ages(WHO world std)e 18 00 05 00 02 04 01 02 01 03

SexMale 39 00 10 00 05 08 02 04 03 07Female 13 00 04 00 03 02 00 02 01 02

RaceWhite 25 00 07 00 04 05 01 03 01 04Black 27 - 05 00 03 06 02 02 02 06Other 19 - 04 - 03 02 01 01 07 02

Table 209Cancer of the Oral Cavity and Pharynx by Subsite (Invasive)

SEER Incidencea Stage Distribution by SiteAge-Adjusted SEER Incidencea and US Deathb Rates by Age Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2016 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2016

d Period survival provides a 2015 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2009-2015 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 45 - - - - -1970-1973a - - - 43 - - - - -1975-1977b 525 516 548 541 538 547 360 297 4901978-1980b 533 518 565 554 545 574 349 298 4581981-1983b 517 501 551 540 528 565 309 254 4561984-1986b 541 517 590 563 548 594 350 295 4911987-1989b 536 510 588 560 541 598 340 300 4401990-1992b 554 532 601 579 564 610 331 284 4601993-1995b 577 562 606 601 594 613 380 331 5051996-1998b 578 562 610 599 591 614 364 313 4951999-2001b 603 592 625 622 620 627 446 396 5712002-2004b 639 631 657 657 657 657 482 428 5882005-2008b 655 651 665 674 672 679 430 407 4802009-2015b 684f 676f 704f 703f 699f 714f 509f 492f 544

5-Year Period Survival (Percent)cd

2015 658 652 674 672 668 682 493 483 515

Stage Distribution () 2009-2015ce

All StagesNumber of cases 57854 41585 16269 47354 34485 12869 5169 3580 1589Percent 100 100 100 100 100 100 100 100 100Localized 29 24 41 30 25 43 19 14 29Regional 47 51 37 48 52 38 48 51 40Distant 20 21 16 18 20 15 30 32 27UnstagedUnknown 4 4 5 4 4 5 3 3 4

5-Year Relative Survival (Percent) 2009-2015c

Age at DiagnosisAges lt45 798 773 839 811 788 849 709 671 757Ages 45-54 702 697 718 728 725 740 500 493 520Ages 55-64 666 656 703 686 675 726 465 459 483Ages 65-74 624 608 665 639 626 673 431 400 498Ages 75+ 512 511 512 521 525 512 327 301 350Ages lt65 697 684 738 716 704 755 514 497 557Ages 65+ 579 575 586 590 590 589 401 378 435

StageeAll Stages 653 646 671 667 664 677 484 467 520Localized 844 832 863 845 836 858 781 738 827Regional 660 672 617 674 688 621 496 500 482Distant 391 399 366 402 412 365 283 290 265UnstagedUnknown 509 511 503 483 487 475 402 453g 322g

Table 2010Cancer of the Oral Cavity and Pharynx (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2016 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2016

d Period survival provides a 2015 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2009-2015 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 45 - - - - -1970-1973a - - - 43 - - - - -1975-1977b 525 516 548 541 538 547 360 297 4901978-1980b 533 518 565 554 545 574 349 298 4581981-1983b 517 501 551 540 528 565 309 254 4561984-1986b 541 517 590 563 548 594 350 295 4911987-1989b 536 510 588 560 541 598 340 300 4401990-1992b 554 532 601 579 564 610 331 284 4601993-1995b 577 562 606 601 594 613 380 331 5051996-1998b 578 562 610 599 591 614 364 313 4951999-2001b 603 592 625 622 620 627 446 396 5712002-2004b 639 631 657 657 657 657 482 428 5882005-2008b 655 651 665 674 672 679 430 407 4802009-2015b 684f 676f 704f 703f 699f 714f 509f 492f 544

5-Year Period Survival (Percent)cd

2015 658 652 674 672 668 682 493 483 515

Stage Distribution () 2009-2015ce

All StagesNumber of cases 57854 41585 16269 47354 34485 12869 5169 3580 1589Percent 100 100 100 100 100 100 100 100 100Localized 29 24 41 30 25 43 19 14 29Regional 47 51 37 48 52 38 48 51 40Distant 20 21 16 18 20 15 30 32 27UnstagedUnknown 4 4 5 4 4 5 3 3 4

5-Year Relative Survival (Percent) 2009-2015c

Age at DiagnosisAges lt45 798 773 839 811 788 849 709 671 757Ages 45-54 702 697 718 728 725 740 500 493 520Ages 55-64 666 656 703 686 675 726 465 459 483Ages 65-74 624 608 665 639 626 673 431 400 498Ages 75+ 512 511 512 521 525 512 327 301 350Ages lt65 697 684 738 716 704 755 514 497 557Ages 65+ 579 575 586 590 590 589 401 378 435

StageeAll Stages 653 646 671 667 664 677 484 467 520Localized 844 832 863 845 836 858 781 738 827Regional 660 672 617 674 688 621 496 500 482Distant 391 399 366 402 412 365 283 290 265UnstagedUnknown 509 511 503 483 487 475 402 453g 322g

Table 2010Cancer of the Oral Cavity and Pharynx (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER program Based on follow-up of patients into 2016

b The standard error is between 5 and 10 percentage pointsc The standard error is greater than 10 percentage pointsd Survival by stage was not calculated for this site due to inconsistent coding of stage over time- Statistic could not be calculated due to fewer than 25 cases during the time period

Case Survival Time

Number Distribution 1-Year 2-Year 3-Year 4-Year 5-Year

Site of Cases () Percent Percent Percent Percent Percent

Oral Cavity amp Pharynx 57854 100 849 759 711 678 653

Lip 3393 6 982 954 937 918 897

Tongue 17556 30 854 760 714 684 664

Gum amp Other Mouth 6868 12 807 707 655 618 590

Floor of Mouth 2490 4 799 669 612 563 517

Oropharynx amp Tonsil 13929 24 874 799 753 721 700

Hypopharynx 2797 5 671 501 421 371 346

Salivary Gland 6169 11 886 815 765 737 714

Nasopharynx 3523 6 842 747 688 650 613

Other Oral Cavity amp Pharynx 1129 2 688 592 535 496 466

5-Year Relative Survival (Percent) 2009-2015

Stage All Stages

Unstaged White White Black Black

Site All Stages Localized Regional Distant Unknown Male Female Male Female

Oral Cavity amp Pharynx 653 844 660 391 509 664 677 467 520

Lip 897 924 604b 275b 869 899 887 666c -

Tongue 664 813 678 390 500 686 665 453 420

Gum amp Other Mouthd 590 - - - - 555 630 489 571

Floor of Mouth 517 769 382 198 400b 508 577 390 382b

Oropharynx amp Tonsild 700 - - - - 726 680 517 455

Hypopharynxd 346 - - - - 373 392 202 173b

Salivary Gland 714 936 652 354 486 615 801 713 810

Nasopharynxd 613 - - - - 570 615 537 499b

Other Oral Cavity amp Pharynxd 466 - - - - 529 379 294b 326b

Table 2011

Cancer of the Oral Cavity and Pharynx by Subsite (Invasive)

SEERa Relative Survival (Percent) by Cancer Site 2009-2015

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 793 791 804 811 827 818 833 808 836 845 824 834 839 844 834 851 848 862 859 873 872 858 860 871 8682-year 658 659 675 694 716 697 713 701 723 736 731 728 750 753 740 753 762 775 775 786 787 782 781 7903-year 598 595 610 632 653 635 662 643 655 686 670 674 703 707 687 706 713 719 731 742 743 731 7264-year 559 555 571 590 614 600 621 601 621 648 625 641 671 669 658 674 684 684 697 711 717 7065-year 528 523 540 561 585 577 585 571 589 620 600 617 652 649 639 651 665 665 673 689 6976-year 505 496 515 536 560 552 560 555 562 598 579 599 639 621 616 628 651 645 653 6727-year 484 475 490 515 535 533 543 540 539 578 561 584 623 605 599 614 628 627 6408-year 462 459 469 494 513 511 532 528 521 556 538 562 608 592 581 594 615 6059-year 443 439 451 471 494 497 517 522 503 539 515 545 584 572 566 579 59410-year 423 422 434 454 478 476 499 511 489 522 494 525 574 555 547 56411-year 404 407 421 436 460 463 478 489 480 505 482 509 554 540 54112-year 390 393 405 424 441 453 461 478 466 488 464 504 529 52713-year 377 376 390 408 425 431 447 462 460 478 460 499 51614-year 367 365 377 396 400 413 438 443 446 465 454 48515-year 352 350 366 386 385 400 425 436 431 457 44116-year 339 337 355 374 376 390 413 425 423 44517-year 329 328 346 363 366 381 404 409 40818-year 319 317 332 352 352 372 391 39719-year 311 302 319 342 346 357 37520-year 299 296 314 334 339 348

Table 2012Cancer of the Oral Cavity and Pharynx (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

Cancer of the Tongue1-year 742 733 768 795 793 791 816 799 805 844 808 810 844 868 847 843 860 867 874 866 880 878 872 876 8692-year 549 575 606 648 652 666 712 658 682 712 706 694 714 755 721 739 765 770 790 765 785 808 785 7953-year 474 508 544 574 586 604 651 591 600 658 638 639 669 709 648 693 706 721 738 719 745 749 7174-year 435 474 499 536 564 573 621 555 579 631 610 617 642 665 614 669 689 697 711 693 719 7335-year 401 446 474 508 540 554 580 528 547 618 584 598 615 648 600 652 669 676 686 674 7136-year 384 418 451 485 504 528 564 522 528 598 563 577 611 616 590 637 656 660 671 6657-year 372 389 424 467 484 512 551 496 505 576 543 567 595 593 575 630 633 651 6598-year 357 374 404 443 465 498 539 480 504 555 506 535 590 569 559 602 617 6319-year 342 348 389 420 446 486 529 474 485 545 481 522 570 550 547 585 59910-year 325 333 375 400 433 466 523 459 477 529 461 499 561 538 520 570

Cancer of the Lip1-year 991 976 992 1000 999 981 1000 992 973 981 951 993 993 996 982 969 961 998 937 1000 983 956 998 1000 10002-year 974 958 980 988 994 941 970 979 951 962 937 993 992 996 953 945 955 990 922 996 983 917 984 9953-year 969 934 972 984 987 928 958 951 937 951 937 971 982 987 951 932 955 982 917 948 983 899 9544-year 957 920 969 973 963 913 934 932 921 927 903 971 982 957 951 901 946 941 905 948 983 8885-year 941 900 958 960 950 886 912 910 905 903 903 939 982 941 951 886 946 941 877 936 9836-year 923 876 950 946 950 874 894 896 893 903 876 936 982 941 951 859 946 920 864 9227-year 912 865 934 933 950 866 882 896 888 902 845 936 973 934 949 859 946 899 8348-year 898 860 918 921 904 832 882 874 885 902 822 934 973 932 915 859 946 8759-year 875 851 913 898 860 825 880 868 881 886 787 908 958 932 888 859 91710-year 858 835 913 880 819 825 855 868 881 884 759 878 954 921 888 859

Cancer of the Oropharynx and Tonsil1-year 705 707 729 744 803 797 811 813 869 822 837 852 826 839 841 852 860 861 886 903 907 865 871 898 8752-year 533 528 559 614 697 663 668 671 748 673 720 760 753 749 743 751 774 786 812 834 838 802 818 8323-year 445 444 457 537 627 606 618 598 669 623 667 714 713 712 706 704 722 733 765 799 798 755 7744-year 389 393 415 491 584 541 563 549 630 574 606 673 680 672 669 684 703 700 739 766 773 7345-year 354 353 378 449 539 526 513 529 597 536 587 644 651 646 654 656 679 675 726 748 7536-year 321 318 346 426 501 477 483 510 575 522 547 635 635 625 641 650 660 658 712 7237-year 302 296 319 413 466 437 473 497 557 488 528 626 626 617 615 629 635 624 7018-year 261 280 301 390 454 423 461 489 521 466 528 595 608 609 593 602 609 6179-year 237 258 283 366 441 413 443 486 519 450 496 589 604 577 578 588 58810-year 224 232 261 354 429 401 436 464 498 431 485 570 580 560 577 588

Table 2013Cancer of the Oral Cavity and Pharynx For Selected Subsites (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 787 785 795 805 826 815 825 803 839 842 828 835 842 850 839 850 859 866 864 873 880 870 855 869 8692-year 650 651 661 682 706 690 698 700 712 730 733 716 748 752 742 746 768 781 779 781 784 792 770 7883-year 590 582 590 614 647 626 646 637 641 674 674 655 700 699 684 693 712 724 723 735 738 739 7124-year 547 540 548 570 603 588 600 591 605 637 622 623 666 655 656 661 677 685 685 699 708 7125-year 516 506 514 541 575 563 563 560 572 608 595 603 651 638 638 642 659 662 663 676 6876-year 494 480 492 517 548 534 538 544 546 582 571 585 641 613 609 622 642 638 644 6637-year 472 459 470 494 518 511 525 528 526 561 552 575 628 600 592 609 618 619 6288-year 452 443 447 476 494 491 514 513 511 537 526 553 610 582 570 588 606 6009-year 432 425 428 453 476 480 497 505 494 518 506 532 584 559 553 575 58210-year 412 406 408 438 458 458 483 496 484 501 487 510 572 541 533 56411-year 392 390 396 422 438 441 464 473 474 484 474 496 554 533 53012-year 380 379 383 408 420 432 445 464 463 465 458 490 530 52213-year 368 363 367 393 403 411 428 449 456 458 458 482 51514-year 358 353 356 380 370 399 414 431 439 444 452 47015-year 345 339 346 369 350 383 401 425 424 436 44016-year 331 327 336 357 340 372 389 410 414 42217-year 320 318 326 346 330 367 379 392 39318-year 311 305 314 334 315 357 369 37919-year 304 287 299 327 309 335 35620-year 293 282 292 318 302 329

Table 2014Cancer of the Oral Cavity and Pharynx (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 808 803 823 823 829 823 852 817 828 851 817 830 834 831 823 854 824 854 846 873 850 829 875 877 8632-year 678 677 706 720 733 712 745 701 744 748 726 753 754 758 734 769 748 763 766 796 795 758 809 7943-year 615 624 653 670 664 654 695 654 685 714 664 716 711 725 692 738 716 707 749 761 755 713 7594-year 585 586 619 631 634 625 669 621 656 671 631 679 682 699 663 704 697 682 724 742 741 6935-year 555 560 592 603 604 603 635 592 621 646 608 646 651 674 642 670 678 670 695 721 7216-year 530 529 563 578 581 589 609 577 597 632 593 630 634 642 630 643 669 661 677 6947-year 510 507 532 559 566 579 582 564 567 616 578 605 614 616 614 624 652 645 6688-year 483 492 516 532 546 551 569 557 541 596 562 582 602 615 604 607 635 6189-year 468 469 497 509 527 531 560 557 521 585 534 571 582 601 593 588 61910-year 447 457 485 489 515 512 536 543 500 568 507 557 575 585 579 56211-year 429 442 470 466 500 506 510 523 492 551 497 536 554 558 56512-year 414 423 451 457 479 494 496 506 472 538 473 532 526 53813-year 399 402 435 440 466 472 487 489 468 523 461 532 51714-year 386 391 420 429 454 443 486 469 462 506 457 51715-year 370 372 407 420 449 435 475 461 445 502 44116-year 358 359 394 411 440 426 465 458 441 49117-year 349 350 385 399 429 409 456 443 43718-year 336 342 368 390 418 402 440 43519-year 325 330 360 374 411 399 41720-year 312 325 357 369 403 385

Table 2015Cancer of the Oral Cavity and Pharynx (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 000 001 117 030 Asian 0 000 000 002 095 033

10 000 001 004 118 030 Pacific 10 000 002 005 095 033

20 001 003 011 118 030 Islander 20 001 005 014 095 033

30 002 011 033 118 031 30 004 012 027 094 033

40 008 031 062 118 031 40 009 024 045 091 033

50 023 055 086 112 031 50 015 037 059 083 032

60 034 067 088 094 028 60 022 045 064 070 030

70 037 061 - 068 023 70 025 045 - 051 026

80 031 - - 041 017 80 023 - - 032 021

White 0 000 000 001 123 030 American 0 000 000 000 077 027

10 000 001 003 124 031 Indian 10 000 000 001 078 027

20 001 003 011 124 031 Alaska 20 000 001 006 078 027

30 002 010 034 124 031 Nativea 30 001 005 024 079 027

40 008 032 066 124 031 40 005 024 048 080 028

50 024 059 091 118 031 50 020 045 063 078 029

60 037 071 093 100 028 60 027 047 060 063 025

70 039 064 - 071 023 70 022 038 - 041 023

80 033 - - 043 018 80 021 - - 025 020

Black 0 000 000 001 079 027 Hispanicb 0 000 000 001 082 024

10 000 001 003 080 027 10 000 001 002 083 024

20 001 003 009 080 027 20 001 002 006 083 024

30 002 009 026 080 028 30 001 006 017 083 024

40 007 025 048 080 028 40 004 016 035 082 024

50 019 043 062 076 028 50 012 031 054 079 024

60 026 047 059 062 024 60 020 044 061 070 023

70 025 039 - 042 019 70 026 045 - 055 020

80 019 - - 024 012 80 024 - - 036 016

Table 2016

Cancer of the Oral Cavity and Pharynx (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2014-2016 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 000 001 166 042 Asian 0 000 000 002 127 046

10 000 001 004 168 043 Pacific 10 000 002 007 128 047

20 001 004 015 168 043 Islander 20 001 006 018 128 047

30 003 014 048 169 043 30 005 017 038 127 047

40 012 046 094 169 044 40 012 034 064 123 046

50 035 085 129 162 043 50 022 053 084 113 045

60 054 101 129 137 040 60 032 064 088 094 041

70 055 088 - 097 032 70 035 061 - 068 036

80 046 - - 058 023 80 031 - - 040 027

White 0 000 000 001 174 042 American 0 000 000 000 104 036

10 000 001 004 176 043 Indian 10 000 000 001 106 037

20 001 003 015 176 043 Alaska 20 000 001 007 106 037

30 003 014 050 178 043 Nativea 30 000 007 036 108 038

40 012 048 100 178 044 40 007 036 072 112 039

50 037 090 137 172 043 50 031 069 095 110 040

60 057 107 137 144 040 60 041 069 082 087 035

70 058 092 - 101 032 70 033 047 - 053 030

80 048 - - 060 024 80 020 - - 028 023

Black 0 000 000 001 112 040 Hispanicb 0 000 000 001 112 033

10 000 001 003 114 041 10 000 001 002 113 033

20 001 003 012 115 041 20 001 002 007 113 033

30 002 011 037 116 042 30 001 007 024 114 034

40 009 036 072 117 043 40 005 023 051 114 034

50 028 066 095 112 043 50 018 047 079 111 034

60 042 075 090 094 038 60 031 065 089 099 033

70 041 060 - 065 029 70 038 065 - 076 028

80 029 - - 036 019 80 035 - - 049 022

Table 2017

Cancer of the Oral Cavity and Pharynx (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2014-2016 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 000 001 071 019 Asian 0 000 001 002 067 022

10 000 001 003 072 019 Pacific 10 000 002 004 068 022

20 001 003 008 071 019 Islander 20 001 004 010 067 022

30 002 007 017 071 019 30 003 008 018 066 022

40 005 016 031 069 019 40 006 015 028 064 022

50 011 027 045 066 019 50 009 023 038 059 022

60 017 036 052 057 018 60 013 029 044 050 020

70 021 038 - 044 016 70 016 032 - 039 019

80 022 - - 029 013 80 018 - - 026 017

White 0 000 000 001 073 019 American 0 000 000 000 050 017

10 000 001 003 074 019 Indian 10 000 000 001 050 017

20 001 003 007 073 019 Alaska 20 000 001 004 051 017

30 002 006 017 073 019 Nativea 30 001 004 013 051 017

40 005 015 032 072 019 40 003 012 025 051 018

50 011 028 047 068 019 50 009 022 034 049 018

60 017 038 054 060 018 60 014 026 041 042 016

70 022 040 - 046 016 70 014 030 - 031 016

80 022 - - 030 013 80 021 - - 022 018

Black 0 000 000 001 049 015 Hispanicb 0 000 000 001 056 015

10 000 001 003 050 015 10 000 001 002 056 016

20 001 002 007 050 015 20 001 002 005 056 016

30 002 006 017 050 015 30 001 004 011 056 016

40 005 015 027 049 015 40 003 009 019 054 016

50 011 023 034 045 015 50 006 017 031 052 016

60 013 025 034 037 013 60 011 026 039 047 015

70 014 024 - 027 011 70 016 030 - 039 014

80 013 - - 017 009 80 017 - - 028 013

Table 2018

Cancer of the Oral Cavity and Pharynx (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2014-2016 By RaceEthnicity

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 47 February 2019 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2007-2016 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2016

d The 2007-2016 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2016

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2007-2016 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2016 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2012-2016 Trend 2007-2016c Trend 2007-2016d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 113 170 64 07 06 02 08 09 08

White 119 179 66 09 10 04 11 13 05White Hispanice 70 103 43 -11 -05 02 - - -White Non-Hispanice 128 193 70 12 13 06 - - -

Black 86 134 50 -18 -22 -11 -24 -27 -15

AsianPacific Islander 84 118 56 -01 01 -05 - - -

Amer IndAlaska Natf 83 118 53 07 07 00 - - -

Hispanice 69 101 42 -02 -05 02 - - -

US Mortalityg Rate 2012-2016 Trend 2007-2016h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 25 39 13 03 05 00

White 25 38 13 07 10 02White Hispanice 16 26 09 -05 -08 -02White Non-Hispanice 26 40 14 08 11 03

Black 27 47 13 -28 -31 -21

AsianPacific Islander 20 31 12 06 08 -12

Amer IndAlaska NatTotal US 15 24 07 -26 -24 -41PRCDA Counties 22 37 10 -05 00 -27Non-PRCDA Counties 08 11 05 -63 -69 -58

Hispanice 15 24 08 -08 -01 -03

Table 2019Cancer of the Oral Cavity and Pharynx (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

The APC is the Annual Percent Change over the time intervala Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

Trends are based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b Incidence data used in calculating the rates and trends are from the SEER 21 areas (San Francisco Connecticut Detroit

Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry Rural GeorgiaCalifornia excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)

- Statistic not shown Rate based on less than 16 cases for the time interval Trend based on less than 10 cases for at leastone year within the time interval

The APC is significantly different from zero (plt05)

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouth Tonsil Hypophar Gland Nasophar Pharynx

2012-2016 Rate per 100000 personsb

All Races

Male and Female 113 06 35 05 15 24 06 13 06 03

Male 170 10 52 07 19 42 10 17 09 04

Female 64 03 19 03 13 09 02 10 04 01

White

Male and Female 119 07 38 05 16 27 06 13 04 03

Male 179 12 58 07 19 46 10 18 06 05

Female 66 04 20 03 13 10 02 10 02 01

Black

Male and Female 86 01 20 04 13 21 08 11 07 02

Male 134 01 32 07 16 37 15 11 10 04

Female 50 - 11 02 10 08 03 11 04 01

Trend 2007-2016b APC()

All Races

Male and Female 06 -05 14 -32 00 22 -27 02 -12 29

Male 06 -11 15 -40 02 24 -27 00 -10 35

Female 02 07 12 -19 -03 11 -33 02 -17 04

White

Male and Female 08 -04 17 -31 -01 27 -26 -01 -29 40

Male 09 -11 18 -38 00 29 -25 -02 -27 44

Female 03 09 12 -17 -02 16 -39 -02 -31 19

Black

Male and Female -17 - -15 -37 -22 -10 -41 05 -09 -31

Male -18 - -18 -40 -22 -07 -49 -04 -11 -12

Female -14 - -13 -31 -23 -17 -07 10 -08 -

Table 2020

Cancer of the Oral Cavity and Pharynx by Subsite (Invasive)

SEER Incidence

Age-Adjusted Rates and Trendsa by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

The APC is the Annual Percent Change over the time intervala US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventionb Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

Trends are based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval Trend based on less than 10 cases for at least

one year within the time interval The APC is significantly different from zero (plt05)

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouth Tonsil Hypophar Gland Nasophar Pharynx

2012-2016 Rate per 100000 persons

All Races

Male and Female 25 00 06 00 04 05 01 03 02 04

Male 39 00 10 00 05 08 02 04 03 07

Female 13 00 04 00 03 02 00 02 01 02

White

Male and Female 25 00 07 00 04 05 01 03 01 04

Male 38 00 10 00 05 08 02 04 02 07

Female 13 00 04 00 03 02 00 02 01 02

Black

Male and Female 27 - 05 00 03 06 02 02 02 06

Male 47 - 08 00 05 11 03 03 04 12

Female 13 - 03 - 02 03 00 01 01 02

Trend 2007-2016 APC()

All Races

Male and Female 04 -05 10 -47 05 27 05 17 -13 -24

Male 06 -17 14 -32 08 29 09 18 -08 -24

Female -03 10 01 -81 00 18 -16 12 -24 -30

White

Male and Female 08 -07 14 -45 07 33 02 18 -18 -21

Male 10 -23 19 -28 11 36 05 21 -15 -21

Female -01 24 03 -80 01 24 -15 09 -23 -28

Black

Male and Female -19 - -20 - -17 -13 12 23 -16 -42

Male -21 - -21 - -26 -15 31 06 -10 -46

Female -15 - -24 - 00 -07 - 41 -34 -35

Table 2021

Cancer of the Oral Cavity and Pharynx by Subsite

US Mortalitya

Age-Adjusted Rates and Trendsb by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 1027 1558 563 1088 1661 577 773 1175 438Greater Bay Area 1024 1514 591 1094 1659 576 807 1321 378San Francisco-Oakland 1049 1562 597 1124 1706 585 837 1385 394San Jose-Monterey 979 1428 580 1042 1576 560 662 1028 -

Los Angeles 891 1350 501 942 1419 527 800 1234 463Greater California 1089 1665 581 1144 1756 597 739 1064 447

Connecticut 1181 1720 713 1211 1756 731 837 1365 469Detroit 1232 1914 654 1280 1969 670 1108 1794 610Georgia 1265 1929 708 1402 2131 758 912 1359 580Atlanta 1103 1673 647 1270 1895 725 814 1284 490Rural Georgia 1404 2400 518 1587 2717 - 1037 1655 -Greater Georgia 1348 2048 750 1452 2211 780 995 1421 660

Hawaii 1325 1882 815 1839 2658 914 - - -Idaho 1223 1730 754 1219 1730 742 - - -Iowa 1307 1952 722 1307 1957 718 934 1209 -Kentucky 1422 2175 765 1443 2198 779 990 1738 411Louisiana 1305 2042 670 1425 2188 741 1003 1669 482Massachusetts 1212 1776 723 1228 1800 728 849 1388 452New Jersey 1065 1620 601 1102 1672 615 839 1312 501New Mexico 880 1361 454 928 1433 477 - - -New York 1092 1632 640 1145 1710 656 771 1176 487Seattle-Puget Sound 1276 1867 747 1333 1944 776 750 1132 328Utah 981 1420 579 983 1427 576 - - -

SEER 9 Areasb 1156 1721 661 1212 1806 675 892 1417 495SEER 13 Areasb 1089 1625 621 1147 1713 637 867 1367 486SEER 18 Areasb 1134 1715 629 1193 1806 648 891 1387 507SEER 21 Areasb 1132 1704 638 1187 1787 656 860 1335 500

Table 2022Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 247 383 133 255 395 137 244 366 149Greater Bay Area 226 354 119 230 355 122 277 519 -San Francisco-Oakland 230 360 123 224 343 122 269 510 -San Jose-Monterey 219 341 113 240 376 123 - - -

Los Angeles 229 353 131 234 357 132 233 321 173Greater California 262 407 140 271 422 142 240 330 158

Connecticut 181 291 093 179 289 089 194 362 -Detroit 255 395 143 249 377 144 285 482 146Georgia 272 408 159 267 398 152 286 447 171Atlanta 232 344 143 221 317 137 246 400 144Rural Georgia 411 692 - 397 622 - - - -Greater Georgia 289 433 167 282 425 158 313 466 197

Hawaii 277 408 166 399 570 225 - - -Idaho 224 318 140 223 319 135 - - -Iowa 245 396 113 245 397 111 - - -Kentucky 313 486 169 317 494 170 271 446 -Louisiana 314 514 149 292 471 143 363 625 161Massachusetts 229 349 130 231 345 136 210 425 -New Jersey 202 322 106 198 312 106 238 388 132New Mexico 236 365 126 246 382 129 - - -New York 214 338 115 214 337 112 208 342 118Seattle-Puget Sound 258 371 160 259 375 156 216 297 -Utah 175 257 099 175 255 102 - - -

SEER 9 Areasb 232 355 128 230 351 125 249 420 126SEER 13 Areasb 231 355 128 231 353 126 249 407 136SEER 18 Areasb 248 385 134 248 384 133 273 436 150SEER 21 Areasb 240 373 130 241 372 129 254 413 138

Total US 251 389 134 250 385 135 273 465 132

Table 2023Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

The APC is the Annual Percent Change over the time intervala Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

Trends are based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b Incidence data used in calculating the rates and trends are from the SEER 21 areas (San Francisco Connecticut Detroit

Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry Rural GeorgiaCalifornia excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)

- Statistic not shown Rate based on less than 16 cases for the time interval Trend based on less than 10 cases for at leastone year within the time interval

The APC is significantly different from zero (plt05)

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouth Tonsil Hypophar Gland Nasophar Pharynx

2012-2016 Rate per 100000 personsb

All Races

Male and Female 113 06 35 05 15 24 06 13 06 03

Male 170 10 52 07 19 42 10 17 09 04

Female 64 03 19 03 13 09 02 10 04 01

White

Male and Female 119 07 38 05 16 27 06 13 04 03

Male 179 12 58 07 19 46 10 18 06 05

Female 66 04 20 03 13 10 02 10 02 01

Black

Male and Female 86 01 20 04 13 21 08 11 07 02

Male 134 01 32 07 16 37 15 11 10 04

Female 50 - 11 02 10 08 03 11 04 01

Trend 2007-2016b APC()

All Races

Male and Female 06 -05 14 -32 00 22 -27 02 -12 29

Male 06 -11 15 -40 02 24 -27 00 -10 35

Female 02 07 12 -19 -03 11 -33 02 -17 04

White

Male and Female 08 -04 17 -31 -01 27 -26 -01 -29 40

Male 09 -11 18 -38 00 29 -25 -02 -27 44

Female 03 09 12 -17 -02 16 -39 -02 -31 19

Black

Male and Female -17 - -15 -37 -22 -10 -41 05 -09 -31

Male -18 - -18 -40 -22 -07 -49 -04 -11 -12

Female -14 - -13 -31 -23 -17 -07 10 -08 -

Table 2020

Cancer of the Oral Cavity and Pharynx by Subsite (Invasive)

SEER Incidence

Age-Adjusted Rates and Trendsa by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

The APC is the Annual Percent Change over the time intervala US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventionb Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

Trends are based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval Trend based on less than 10 cases for at least

one year within the time interval The APC is significantly different from zero (plt05)

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouth Tonsil Hypophar Gland Nasophar Pharynx

2012-2016 Rate per 100000 persons

All Races

Male and Female 25 00 06 00 04 05 01 03 02 04

Male 39 00 10 00 05 08 02 04 03 07

Female 13 00 04 00 03 02 00 02 01 02

White

Male and Female 25 00 07 00 04 05 01 03 01 04

Male 38 00 10 00 05 08 02 04 02 07

Female 13 00 04 00 03 02 00 02 01 02

Black

Male and Female 27 - 05 00 03 06 02 02 02 06

Male 47 - 08 00 05 11 03 03 04 12

Female 13 - 03 - 02 03 00 01 01 02

Trend 2007-2016 APC()

All Races

Male and Female 04 -05 10 -47 05 27 05 17 -13 -24

Male 06 -17 14 -32 08 29 09 18 -08 -24

Female -03 10 01 -81 00 18 -16 12 -24 -30

White

Male and Female 08 -07 14 -45 07 33 02 18 -18 -21

Male 10 -23 19 -28 11 36 05 21 -15 -21

Female -01 24 03 -80 01 24 -15 09 -23 -28

Black

Male and Female -19 - -20 - -17 -13 12 23 -16 -42

Male -21 - -21 - -26 -15 31 06 -10 -46

Female -15 - -24 - 00 -07 - 41 -34 -35

Table 2021

Cancer of the Oral Cavity and Pharynx by Subsite

US Mortalitya

Age-Adjusted Rates and Trendsb by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 1027 1558 563 1088 1661 577 773 1175 438Greater Bay Area 1024 1514 591 1094 1659 576 807 1321 378San Francisco-Oakland 1049 1562 597 1124 1706 585 837 1385 394San Jose-Monterey 979 1428 580 1042 1576 560 662 1028 -

Los Angeles 891 1350 501 942 1419 527 800 1234 463Greater California 1089 1665 581 1144 1756 597 739 1064 447

Connecticut 1181 1720 713 1211 1756 731 837 1365 469Detroit 1232 1914 654 1280 1969 670 1108 1794 610Georgia 1265 1929 708 1402 2131 758 912 1359 580Atlanta 1103 1673 647 1270 1895 725 814 1284 490Rural Georgia 1404 2400 518 1587 2717 - 1037 1655 -Greater Georgia 1348 2048 750 1452 2211 780 995 1421 660

Hawaii 1325 1882 815 1839 2658 914 - - -Idaho 1223 1730 754 1219 1730 742 - - -Iowa 1307 1952 722 1307 1957 718 934 1209 -Kentucky 1422 2175 765 1443 2198 779 990 1738 411Louisiana 1305 2042 670 1425 2188 741 1003 1669 482Massachusetts 1212 1776 723 1228 1800 728 849 1388 452New Jersey 1065 1620 601 1102 1672 615 839 1312 501New Mexico 880 1361 454 928 1433 477 - - -New York 1092 1632 640 1145 1710 656 771 1176 487Seattle-Puget Sound 1276 1867 747 1333 1944 776 750 1132 328Utah 981 1420 579 983 1427 576 - - -

SEER 9 Areasb 1156 1721 661 1212 1806 675 892 1417 495SEER 13 Areasb 1089 1625 621 1147 1713 637 867 1367 486SEER 18 Areasb 1134 1715 629 1193 1806 648 891 1387 507SEER 21 Areasb 1132 1704 638 1187 1787 656 860 1335 500

Table 2022Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 247 383 133 255 395 137 244 366 149Greater Bay Area 226 354 119 230 355 122 277 519 -San Francisco-Oakland 230 360 123 224 343 122 269 510 -San Jose-Monterey 219 341 113 240 376 123 - - -

Los Angeles 229 353 131 234 357 132 233 321 173Greater California 262 407 140 271 422 142 240 330 158

Connecticut 181 291 093 179 289 089 194 362 -Detroit 255 395 143 249 377 144 285 482 146Georgia 272 408 159 267 398 152 286 447 171Atlanta 232 344 143 221 317 137 246 400 144Rural Georgia 411 692 - 397 622 - - - -Greater Georgia 289 433 167 282 425 158 313 466 197

Hawaii 277 408 166 399 570 225 - - -Idaho 224 318 140 223 319 135 - - -Iowa 245 396 113 245 397 111 - - -Kentucky 313 486 169 317 494 170 271 446 -Louisiana 314 514 149 292 471 143 363 625 161Massachusetts 229 349 130 231 345 136 210 425 -New Jersey 202 322 106 198 312 106 238 388 132New Mexico 236 365 126 246 382 129 - - -New York 214 338 115 214 337 112 208 342 118Seattle-Puget Sound 258 371 160 259 375 156 216 297 -Utah 175 257 099 175 255 102 - - -

SEER 9 Areasb 232 355 128 230 351 125 249 420 126SEER 13 Areasb 231 355 128 231 353 126 249 407 136SEER 18 Areasb 248 385 134 248 384 133 273 436 150SEER 21 Areasb 240 373 130 241 372 129 254 413 138

Total US 251 389 134 250 385 135 273 465 132

Table 2023Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

The APC is the Annual Percent Change over the time intervala US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventionb Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

Trends are based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval Trend based on less than 10 cases for at least

one year within the time interval The APC is significantly different from zero (plt05)

Site Oral Gum amp Oropharynx Other Oral

Cavity amp Floor of Other amp Salivary Cavity ampPharynx Lip Tongue Mouth Mouth Tonsil Hypophar Gland Nasophar Pharynx

2012-2016 Rate per 100000 persons

All Races

Male and Female 25 00 06 00 04 05 01 03 02 04

Male 39 00 10 00 05 08 02 04 03 07

Female 13 00 04 00 03 02 00 02 01 02

White

Male and Female 25 00 07 00 04 05 01 03 01 04

Male 38 00 10 00 05 08 02 04 02 07

Female 13 00 04 00 03 02 00 02 01 02

Black

Male and Female 27 - 05 00 03 06 02 02 02 06

Male 47 - 08 00 05 11 03 03 04 12

Female 13 - 03 - 02 03 00 01 01 02

Trend 2007-2016 APC()

All Races

Male and Female 04 -05 10 -47 05 27 05 17 -13 -24

Male 06 -17 14 -32 08 29 09 18 -08 -24

Female -03 10 01 -81 00 18 -16 12 -24 -30

White

Male and Female 08 -07 14 -45 07 33 02 18 -18 -21

Male 10 -23 19 -28 11 36 05 21 -15 -21

Female -01 24 03 -80 01 24 -15 09 -23 -28

Black

Male and Female -19 - -20 - -17 -13 12 23 -16 -42

Male -21 - -21 - -26 -15 31 06 -10 -46

Female -15 - -24 - 00 -07 - 41 -34 -35

Table 2021

Cancer of the Oral Cavity and Pharynx by Subsite

US Mortalitya

Age-Adjusted Rates and Trendsb by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 1027 1558 563 1088 1661 577 773 1175 438Greater Bay Area 1024 1514 591 1094 1659 576 807 1321 378San Francisco-Oakland 1049 1562 597 1124 1706 585 837 1385 394San Jose-Monterey 979 1428 580 1042 1576 560 662 1028 -

Los Angeles 891 1350 501 942 1419 527 800 1234 463Greater California 1089 1665 581 1144 1756 597 739 1064 447

Connecticut 1181 1720 713 1211 1756 731 837 1365 469Detroit 1232 1914 654 1280 1969 670 1108 1794 610Georgia 1265 1929 708 1402 2131 758 912 1359 580Atlanta 1103 1673 647 1270 1895 725 814 1284 490Rural Georgia 1404 2400 518 1587 2717 - 1037 1655 -Greater Georgia 1348 2048 750 1452 2211 780 995 1421 660

Hawaii 1325 1882 815 1839 2658 914 - - -Idaho 1223 1730 754 1219 1730 742 - - -Iowa 1307 1952 722 1307 1957 718 934 1209 -Kentucky 1422 2175 765 1443 2198 779 990 1738 411Louisiana 1305 2042 670 1425 2188 741 1003 1669 482Massachusetts 1212 1776 723 1228 1800 728 849 1388 452New Jersey 1065 1620 601 1102 1672 615 839 1312 501New Mexico 880 1361 454 928 1433 477 - - -New York 1092 1632 640 1145 1710 656 771 1176 487Seattle-Puget Sound 1276 1867 747 1333 1944 776 750 1132 328Utah 981 1420 579 983 1427 576 - - -

SEER 9 Areasb 1156 1721 661 1212 1806 675 892 1417 495SEER 13 Areasb 1089 1625 621 1147 1713 637 867 1367 486SEER 18 Areasb 1134 1715 629 1193 1806 648 891 1387 507SEER 21 Areasb 1132 1704 638 1187 1787 656 860 1335 500

Table 2022Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 247 383 133 255 395 137 244 366 149Greater Bay Area 226 354 119 230 355 122 277 519 -San Francisco-Oakland 230 360 123 224 343 122 269 510 -San Jose-Monterey 219 341 113 240 376 123 - - -

Los Angeles 229 353 131 234 357 132 233 321 173Greater California 262 407 140 271 422 142 240 330 158

Connecticut 181 291 093 179 289 089 194 362 -Detroit 255 395 143 249 377 144 285 482 146Georgia 272 408 159 267 398 152 286 447 171Atlanta 232 344 143 221 317 137 246 400 144Rural Georgia 411 692 - 397 622 - - - -Greater Georgia 289 433 167 282 425 158 313 466 197

Hawaii 277 408 166 399 570 225 - - -Idaho 224 318 140 223 319 135 - - -Iowa 245 396 113 245 397 111 - - -Kentucky 313 486 169 317 494 170 271 446 -Louisiana 314 514 149 292 471 143 363 625 161Massachusetts 229 349 130 231 345 136 210 425 -New Jersey 202 322 106 198 312 106 238 388 132New Mexico 236 365 126 246 382 129 - - -New York 214 338 115 214 337 112 208 342 118Seattle-Puget Sound 258 371 160 259 375 156 216 297 -Utah 175 257 099 175 255 102 - - -

SEER 9 Areasb 232 355 128 230 351 125 249 420 126SEER 13 Areasb 231 355 128 231 353 126 249 407 136SEER 18 Areasb 248 385 134 248 384 133 273 436 150SEER 21 Areasb 240 373 130 241 372 129 254 413 138

Total US 251 389 134 250 385 135 273 465 132

Table 2023Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 1027 1558 563 1088 1661 577 773 1175 438Greater Bay Area 1024 1514 591 1094 1659 576 807 1321 378San Francisco-Oakland 1049 1562 597 1124 1706 585 837 1385 394San Jose-Monterey 979 1428 580 1042 1576 560 662 1028 -

Los Angeles 891 1350 501 942 1419 527 800 1234 463Greater California 1089 1665 581 1144 1756 597 739 1064 447

Connecticut 1181 1720 713 1211 1756 731 837 1365 469Detroit 1232 1914 654 1280 1969 670 1108 1794 610Georgia 1265 1929 708 1402 2131 758 912 1359 580Atlanta 1103 1673 647 1270 1895 725 814 1284 490Rural Georgia 1404 2400 518 1587 2717 - 1037 1655 -Greater Georgia 1348 2048 750 1452 2211 780 995 1421 660

Hawaii 1325 1882 815 1839 2658 914 - - -Idaho 1223 1730 754 1219 1730 742 - - -Iowa 1307 1952 722 1307 1957 718 934 1209 -Kentucky 1422 2175 765 1443 2198 779 990 1738 411Louisiana 1305 2042 670 1425 2188 741 1003 1669 482Massachusetts 1212 1776 723 1228 1800 728 849 1388 452New Jersey 1065 1620 601 1102 1672 615 839 1312 501New Mexico 880 1361 454 928 1433 477 - - -New York 1092 1632 640 1145 1710 656 771 1176 487Seattle-Puget Sound 1276 1867 747 1333 1944 776 750 1132 328Utah 981 1420 579 983 1427 576 - - -

SEER 9 Areasb 1156 1721 661 1212 1806 675 892 1417 495SEER 13 Areasb 1089 1625 621 1147 1713 637 867 1367 486SEER 18 Areasb 1134 1715 629 1193 1806 648 891 1387 507SEER 21 Areasb 1132 1704 638 1187 1787 656 860 1335 500

Table 2022Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 247 383 133 255 395 137 244 366 149Greater Bay Area 226 354 119 230 355 122 277 519 -San Francisco-Oakland 230 360 123 224 343 122 269 510 -San Jose-Monterey 219 341 113 240 376 123 - - -

Los Angeles 229 353 131 234 357 132 233 321 173Greater California 262 407 140 271 422 142 240 330 158

Connecticut 181 291 093 179 289 089 194 362 -Detroit 255 395 143 249 377 144 285 482 146Georgia 272 408 159 267 398 152 286 447 171Atlanta 232 344 143 221 317 137 246 400 144Rural Georgia 411 692 - 397 622 - - - -Greater Georgia 289 433 167 282 425 158 313 466 197

Hawaii 277 408 166 399 570 225 - - -Idaho 224 318 140 223 319 135 - - -Iowa 245 396 113 245 397 111 - - -Kentucky 313 486 169 317 494 170 271 446 -Louisiana 314 514 149 292 471 143 363 625 161Massachusetts 229 349 130 231 345 136 210 425 -New Jersey 202 322 106 198 312 106 238 388 132New Mexico 236 365 126 246 382 129 - - -New York 214 338 115 214 337 112 208 342 118Seattle-Puget Sound 258 371 160 259 375 156 216 297 -Utah 175 257 099 175 255 102 - - -

SEER 9 Areasb 232 355 128 230 351 125 249 420 126SEER 13 Areasb 231 355 128 231 353 126 249 407 136SEER 18 Areasb 248 385 134 248 384 133 273 436 150SEER 21 Areasb 240 373 130 241 372 129 254 413 138

Total US 251 389 134 250 385 135 273 465 132

Table 2023Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 247 383 133 255 395 137 244 366 149Greater Bay Area 226 354 119 230 355 122 277 519 -San Francisco-Oakland 230 360 123 224 343 122 269 510 -San Jose-Monterey 219 341 113 240 376 123 - - -

Los Angeles 229 353 131 234 357 132 233 321 173Greater California 262 407 140 271 422 142 240 330 158

Connecticut 181 291 093 179 289 089 194 362 -Detroit 255 395 143 249 377 144 285 482 146Georgia 272 408 159 267 398 152 286 447 171Atlanta 232 344 143 221 317 137 246 400 144Rural Georgia 411 692 - 397 622 - - - -Greater Georgia 289 433 167 282 425 158 313 466 197

Hawaii 277 408 166 399 570 225 - - -Idaho 224 318 140 223 319 135 - - -Iowa 245 396 113 245 397 111 - - -Kentucky 313 486 169 317 494 170 271 446 -Louisiana 314 514 149 292 471 143 363 625 161Massachusetts 229 349 130 231 345 136 210 425 -New Jersey 202 322 106 198 312 106 238 388 132New Mexico 236 365 126 246 382 129 - - -New York 214 338 115 214 337 112 208 342 118Seattle-Puget Sound 258 371 160 259 375 156 216 297 -Utah 175 257 099 175 255 102 - - -

SEER 9 Areasb 232 355 128 230 351 125 249 420 126SEER 13 Areasb 231 355 128 231 353 126 249 407 136SEER 18 Areasb 248 385 134 248 384 133 273 436 150SEER 21 Areasb 240 373 130 241 372 129 254 413 138

Total US 251 389 134 250 385 135 273 465 132

Table 2023Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 251 001

High Five StatesMississippi 356 014 01(0105) 4181c

Vermont 322 029 02(0130) 2853c

Arkansas 318 013 03(0114) 2678c

Louisiana 314 011 04(0112) 2506c

Kentucky 313 011 05(0113) 2473c

Low Five StatesWyoming 198 025 47(1251) -2109c

Colorado 193 008 48(3951) -2312c

Connecticut 181 009 49(4351) -2780c

Utah 175 012 50(4251) -3038c

Rhode Island 162 015 51(4351) -3556c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 280 010 11(0427) 1170 Montana 225 019 38(1150) -1036Alaska 237 029 32(0251) -545 Nebraska 217 014 43(2350) -1360Arizona 203 007 45(3750) -1901c Nevada 261 013 21(0640) 421Arkansas 318 013 03(0114) 2678c New Hampshire 240 017 31(0848) -423California 247 004 26(2235) -149 New Jersey 202 006 46(3949) -1948c

Colorado 193 008 48(3951) -2312c New Mexico 236 014 34(1147) -574Connecticut 181 009 49(4351) -2780c New York 214 004 44(3547) -1448Delaware 251 021 25(0448) 011 North Carolina 259 007 23(1133) 342DC 298 031 08(0142) 1879c North Dakota 230 024 35(0551) -826Florida 268 004 19(1026) 696 Ohio 269 006 18(0928) 722Georgia 272 007 14(0728) 841 Oklahoma 271 011 15(0533) 819Hawaii 277 018 13(0239) 1066 Oregon 279 011 12(0428) 1125Idaho 224 016 39(1450) -1053 Pennsylvania 224 005 40(3045) -1054Illinois 260 006 22(1132) 366 Rhode Island 162 015 51(4351) -3556c

Indiana 237 008 33(2143) -546 South Carolina 297 010 09(0219) 1861c

Iowa 245 011 28(1143) -211 South Dakota 223 022 41(0951) -1096Kansas 218 012 42(2549) -1313 Tennessee 299 009 07(0216) 1926c

Kentucky 313 011 05(0113) 2473c Texas 256 004 24(1633) 198Louisiana 314 011 04(0112) 2506c Utah 175 012 50(4251) -3038c

Maine 291 018 10(0132) 1590c Vermont 322 029 02(0130) 2853c

Maryland 242 009 30(1642) -362 Virginia 244 007 29(1840) -267Massachusetts 229 008 36(2545) -878 Washington 267 008 20(0832) 640Michigan 270 007 16(0928) 759 West Virginia 302 016 06(0124) 2040c

Minnesota 227 009 37(2446) -930 Wisconsin 246 008 27(1540) -194Mississippi 356 014 01(0105) 4181c Wyoming 198 025 47(1251) -2109c

Missouri 270 009 17(0731) 753

Table 2024Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 389 002

High Five StatesMississippi 601 028 01(0104) 5436c

Louisiana 514 021 02(0111) 3217c

DC 501 061 03(0142) 2880c

Arkansas 498 025 04(0113) 2800c

Kentucky 486 021 05(0215) 2494c

Low Five StatesWyoming 292 045 47(1251) -2506c

Connecticut 291 017 48(3651) -2513c

Colorado 281 015 49(4051) -2793c

Utah 257 022 50(4051) -3402c

Rhode Island 220 027 51(4451) -4339c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 460 019 11(0221) 1814c Montana 344 034 37(1050) -1169Alaska 352 051 35(0251) -952 Nebraska 308 025 45(2551) -2089c

Arizona 317 013 44(3349) -1861c Nevada 395 023 23(0841) 157Arkansas 498 025 04(0113) 2800c New Hampshire 363 030 32(0948) -668California 383 007 26(1934) -160 New Jersey 322 012 42(3248) -1720c

Colorado 281 015 49(4051) -2793c New Mexico 365 025 31(1147) -625Connecticut 291 017 48(3651) -2513c New York 338 008 39(3045) -1318Delaware 359 037 33(0650) -780 North Carolina 407 013 19(0931) 469DC 501 061 03(0142) 2880c North Dakota 298 040 46(1251) -2348c

Florida 420 008 15(0924) 798 Ohio 423 012 13(0826) 869Georgia 408 014 17(0932) 480 Oklahoma 429 021 12(0432) 1013Hawaii 408 032 18(0343) 477 Oregon 397 019 21(0938) 203Idaho 318 028 43(2051) -1830c Pennsylvania 355 010 34(2542) -879Illinois 394 011 25(1334) 111 Rhode Island 220 027 51(4451) -4339c

Indiana 366 015 30(1743) -606 South Carolina 468 019 08(0218) 2019c

Iowa 396 022 22(0841) 169 South Dakota 342 039 38(0751) -1207Kansas 332 021 41(2249) -1479 Tennessee 482 017 06(0213) 2387c

Kentucky 486 021 05(0215) 2494c Texas 405 008 20(1229) 406Louisiana 514 021 02(0111) 3217c Utah 257 022 50(4051) -3402c

Maine 461 034 10(0232) 1846c Vermont 478 051 07(0142) 2269c

Maryland 374 016 28(1342) -382 Virginia 370 014 29(1741) -484Massachusetts 349 014 36(2346) -1033 Washington 394 015 24(1036) 116Michigan 415 012 16(0829) 662 West Virginia 463 029 09(0228) 1897c

Minnesota 334 015 40(2748) -1410 Wisconsin 378 015 27(1341) -290Mississippi 601 028 01(0104) 5436c Wyoming 292 045 47(1251) -2506c

Missouri 420 016 14(0730) 801

Table 2025Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 134 001

High Five StatesVermont 184 029 01(0147) 3733c

Oregon 175 012 02(0122) 3046c

North Dakota 172 029 03(0150) 2851c

Kentucky 169 011 04(0125) 2610c

Hawaii 166 019 05(0143) 2371c

Low Five StatesRhode Island 112 017 47(0551) -1630c

New Jersey 106 006 48(3651) -2115c

Arizona 104 007 49(3451) -2253c

Utah 099 013 50(2351) -2610c

Connecticut 093 009 51(3851) -3069c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 134 009 30(0746) -030 Montana 115 018 43(0451) -1403Alaska 120 030 40(0151) -1078 Nebraska 137 015 26(0150) 232Arizona 104 007 49(3451) -2253c Nevada 138 013 23(0249) 310Arkansas 166 014 06(0135) 2351c New Hampshire 130 018 32(0251) -277California 133 004 31(1639) -049 New Jersey 106 006 48(3651) -2115c

Colorado 115 009 42(1751) -1394 New Mexico 126 014 37(0551) -637Connecticut 093 009 51(3851) -3069c New York 115 004 44(3349) -1436Delaware 158 023 08(0150) 1800c North Carolina 140 007 20(0740) 444DC 149 029 14(0151) 1095 North Dakota 172 029 03(0150) 2851c

Florida 138 004 24(1238) 254 Ohio 140 006 22(0839) 417Georgia 159 008 07(0126) 1848c Oklahoma 134 010 28(0548) -023Hawaii 166 019 05(0143) 2371c Oregon 175 012 02(0122) 3046c

Idaho 140 018 21(0150) 418 Pennsylvania 116 005 41(2949) -1336Illinois 149 006 13(0431) 1128 Rhode Island 112 017 47(0551) -1630c

Indiana 128 008 36(1347) -483 South Carolina 155 010 11(0137) 1564c

Iowa 113 010 45(1851) -1558c South Dakota 120 022 39(0151) -1054Kansas 122 012 38(0951) -927 Tennessee 146 008 17(0338) 904Kentucky 169 011 04(0125) 2610c Texas 130 004 33(1742) -300Louisiana 149 010 15(0241) 1076 Utah 099 013 50(2351) -2610c

Maine 144 017 18(0149) 713 Vermont 184 029 01(0147) 3733c

Maryland 134 009 27(0845) 007 Virginia 137 007 25(0842) 240Massachusetts 130 008 34(1146) -301 Washington 157 009 09(0132) 1722c

Michigan 147 007 16(0536) 934 West Virginia 156 015 10(0143) 1636c

Minnesota 134 009 29(0846) -030 Wisconsin 129 008 35(1148) -399Mississippi 153 013 12(0141) 1398 Wyoming 113 027 46(0151) -1584c

Missouri 141 008 19(0542) 494

Table 2026Cancer of the Oral Cavity and Pharynx (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex

All Races Both Sexes 137601 83078 52272 33186 16846 322983 47326 370309Males 97382 56660 34723 21268 10139 220172 29888 250059Females 40219 26418 17549 11918 6707 102811 17438 120250

White Both Sexes 119389 71998 45504 28485 14475 279851 40358 325100Males 85471 49690 30750 18599 8853 193362 25529 222024Females 33919 22309 14754 9885 5622 86489 14829 103077

Black Both Sexes 10229 5844 3613 2443 1333 23462 2368 25830Males 6966 3712 2101 1354 678 14811 1246 16057Females 3262 2132 1512 1090 655 8651 1121 9773

Asian Both Sexes 5206 3370 2197 1497 670 12941 + +Pacific Males 3161 2040 1290 850 380 7721 + +Islander Females 2045 1330 907 647 290 5220 + +

Hispanic Both Sexes 7864 4600 2787 1690 868 17809 + +Males 5180 2704 1697 983 418 10982 + +Females 2684 1896 1090 707 450 6828 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex

All Races Both Sexes 01002 00004 00023 00066 00168 00488 01514 02996 03762 03571 00835Males 01388 00004 00023 00062 00162 00604 02212 04620 05721 05369 01218Females 00629 00004 00024 00071 00174 00374 00848 01524 02130 02464 00509

White Both Sexes 01110 00004 00021 00065 00162 00480 01574 03148 03973 03757 00868Males 01548 00004 00020 00059 00153 00603 02321 04855 06023 05628 01269Females 00680 00004 00023 00072 00172 00356 00846 01566 02228 02585 00518

Black Both Sexes 00520 00004 00029 00068 00144 00395 01077 02014 02167 01750 00546Males 00685 00005 00031 00073 00142 00444 01503 03108 03419 02814 00791Females 00369 00003 00027 00063 00146 00352 00705 01141 01295 01224 00366

Asian Both Sexes 00636 - 00022 00061 00237 00607 01289 01964 02441 02337 00650Pacific Males 00792 - 00027 00058 00268 00733 01718 02771 03360 03056 00859Islander Females 00492 - 00017 00064 00208 00496 00918 01312 01703 01873 00479

Hispanic Both Sexes 00312 00005 00019 00048 00093 00284 00713 01499 02128 02184 00456Males 00381 00006 00019 00047 00086 00323 00941 02145 02996 03112 00616Females 00242 00003 00019 00050 00100 00243 00489 00927 01463 01610 00326

Table 2027Cancer of the Oral Cavity and Pharynx (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Source SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts)Percents may not sum to 100 due to rounding

a Excludes Kaposi Sarcoma mesothelioma lymphomas leukemias myelomas lymphoreticular and immunoproliferative diseasesb Epidermoid carcinoma includes squamous basal and transitional cell carcinomasc Adenocarcinoma includes histologies 8050 8140-8147 8160-8162 8180-8221 8250-8507 8514 8520-8551 8560 8570-8574

8576 8940-8941d Other specific carcinomas includes histologies 8012-8015 8030-8046 8150-8155 8170-8180 8230-8249 8508 8510-8513

8561-8562 8575 8580-8671e Sarcoma and soft tissue includes histologies 8680-8713 8800-8921 8990-8991 9040-9044 9120-9136 9150-9252 9370-9373

9540-9582f Other specific types includes histologies 8720-8790 8930-8936 8950-8983 9060-9110 9260-9365 9380-9539- Statistic not shown due to fewer than 16 cases during the time period

Oral Cavityand Pharynx Lip Tongue Salivary Gland Floor of Mouth

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 63339 854 3814 943 22466 977 1766 216 3088 958Squamous cell carcinoma 61917 835 3608 892 22108 961 1685 206 3055 948(8070-80788083-8084)

Adenocarcinomac 7315 99 166 41 277 12 5108 625 109 34Other specific carcinomasd 673 09 - - 65 03 414 51 - -Unspecified Carcinoma NOS 1948 26 - - 104 05 550 67 - -(8010-80118020-8022)

Sarcoma and soft tissuee 233 03 - - 34 01 53 06 - -Other specific typesf 413 06 36 09 - - 205 25 - -Unspecified (8000-8005) 244 03 - - 42 02 76 09 - -Total 74166 1000 4044 1000 23000 1000 8172 1000 3224 1000

OtherGum and Oropharynx Oral Cavity

Other Mouth Nasopharynx and Tonsil Hypopharynx and Pharynx Histologya Count Percent Count Percent Count Percent Count Percent Count Percent

Epidermoid carcinomab (8051-8131) 8194 827 2605 672 16315 983 3677 973 1414 900Squamous cell carcinoma 7805 788 2454 633 16150 973 3648 965 1404 894(8070-80788083-8084)

Adenocarcinomac 1400 141 122 31 86 05 21 06 26 17Other specific carcinomasd 46 05 38 10 47 03 33 09 17 11Unspecified Carcinoma NOS 70 07 1037 267 88 05 23 06 59 38(8010-80118020-8022)

Sarcoma and soft tissuee 46 05 46 12 17 01 17 04 - -Other specific typesf 125 13 - - - - - - - -Unspecified (8000-8005) 23 02 16 04 28 02 - - 42 27Total 9905 1000 3878 1000 16592 1000 3780 1000 1571 1000

Table 2028

Cancer of the Oral Cavity and Pharynx (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases 2012-2016All Races Both Sexes by site

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 20160

5

10

15

1975 1985 1995 2005 2016

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Oral Cavity and Pharynx by Race and Sex

a

Figure 201

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2003-16 = 14Observed 2003-16 = 13

US Mortality APC2005-16 = 09

SEER Incidence APCsDelay Adj 1986-16 = -27Observed 1986-16 = -27

US Mortality APC2008-16 = -22

SEER Incidence APCsDelay Adj 2005-16 = 08Observed 2004-16 = 05

US Mortality APC2014-16 = 53

SEER Incidence APCsDelay Adj 1975-16 = -15Observed 1975-16 = -15

US Mortality APC2005-16 = -14

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

1975 1985 1995 2005 20160

5

10

15

20

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Oral Cavity and Pharynx Both Sexes

Figure 202

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

1

2

3

4

5

6

7

1975 1985 1995 2005 20160

1

2

3

4

5

6

7

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence RatesCancer of the Oral Cavity and Pharangeal for Selected Subsites Both Sexes

Figure 203

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsRegression lines could not be calculated for data series that had at least one diagnosis year with a 0 case countAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Tongue Oropharynx amp TonsilRate per 100000 Rate per 100000

Year of Diagnosis Year of Diagnosis

a

d

a

b

c

cb

d

Nasopharynx Lip

0

1

2

3

4

5

6

7

1975 1985 1995 2005 2016Year of Diagnosis Year of Diagnosis

Rate per 100000 Rate per 100000

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence Oral Cavity and Pharynx Subsites
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• Incidence Rates and Stage Distribution for Oral Cavity and Pharynx Subsites
• 5-year Relative and Period Survival
• Relative Survival by Oral Cavity and Pharynx Subsites
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Subsite and Year of Diagnosis
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Incidence Rates and Trends by Race and Subsite
• Death Rates and Mortality Trends by Race and Subsites
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Case Distribution by Histology
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence Rates by RaceEthnicity