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Second IVIG dose for Guillain Barré syndrome Dr. Vương Chinh Quyên Neurology department Children Hospital 2

Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

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Page 1: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Second IVIG dose for

Guillain Barré syndrome

Dr. Vương Chinh Quyên

Neurology department

Children Hospital 2

Page 2: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Content

1. Standard treatment for GBS

2. Second IVIG dose

3. Clinical case

Page 3: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

1. Standard treatment

for GBS

Page 4: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

GBS

Nguồn: Nazgol Motamed-Gorji (2016) Biological drugs in Guillain-Barré Syndrome: an

update, Current Neuropharmacology

Page 5: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Types, Levin, 2004

Page 6: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Outcome

IVIG = PE (Class I, Level A)

10% TRF – GBS

5% CIDP

Page 7: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

TRF- GBS:

Nguồn: Krista Kuitwaard (2016), The Spectrum of GBS and CIDP, GBS 100.

Page 8: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic
Page 9: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

2. Second IVIG dose

Page 10: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

A Further course of IVIG

Nguồn: Winer J.B (2014), An Update in Guillain-Barré Syndrome, Hindawi Publishing

Corporation Autoimmune Diseases, Volume 2014

Page 11: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Second IVIG dose

Nguồn: Angelika F. Hahn (2016) Intravenous Immunoglobulin (IVIg) for Guillain-Barré Syndrome: The Journey and Current Practice, GBS 100

Page 12: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

IVIG Trial

Page 13: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Nguồn: Hugh J Willison, Bart C Jacobs, Pieter A van Doorn (2016) Guillain-Barré syndrome, Lancet; 388: 717–27

Page 14: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

3. Clincal case

Page 15: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

BÙI TRẦN ĐÔNG N.

Female

BOD: 26/5/2014.

Address: Bà Rịa - Vũng Tàu

Hospitalized: (20/10/2017): weakness

History

Page 16: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Bệnh sử và diễn tiến:

GBS

22/10/2017-10/11/2017

• GBS

• IVIG

1/12/2017-12/1/2018

• TRF-GBS

• IVIG

25/1/2018 –10/3/2018

• A-CIDP

• IVIG

Page 17: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

Take home message

Page 18: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

1 •First IVIG

2 •SID for TRF-GBS

3 •Look for A-CIDP

For GBS

Page 19: Second IVIG dose for Guillain Barré syndrome - K_ TK.pdf · Guillain-Barré Syndrome (GBS) is a term used to describe acute autoimmune peripheral neuropathy with specific characteristic

https://www.gbs-cidp.org

Thank for your attention /