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Transcriptional noise in scRNA-Seq data Aging within mus musculus

scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

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Page 1: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Transcriptional noise in

scRNA-Seq data Aging within mus musculus

Page 2: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Page 3: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Page 4: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

What They Did

Page 5: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

What They Got

Page 6: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Repeating Results: Clustering

Page 7: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Repeating Results: Clustering

Page 8: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Repeating Results: Estimated Noise

Cluster

Estimated noise

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* - adjusted p-value < 0.01§ - adjusted p-value < 0.1

Page 9: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Transcriptional Noise in Brain AgingData Source:

Page 10: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Expression of Canonical Markers

Page 11: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

Expression of Canonical Markers

Page 12: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

What We Found

?

Page 13: scRNA-Seq data noise in Transcriptionalbioinformaticsinstitute.ru/sites/default/files/transcriptional_noise.pdf · However, it is difficult to capture rare dynamic processes, such

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