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Page 1: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg
Page 2: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Scientific Program at a Glance

4th International Conference "Strategies in Tissue Engineering" 2015 1

Wednesday, June 10th

Franconia

Hall Room 11/12 Room 13

10:00 - 10:20 Opening

10:20 - 11:00 Plenary Lecture:

Materials

11:00 - 12:30 Regenerative

Materials I

Bioreactor Technology &

Automatization

Healthy Aging (Epigenetics)

12:30 - 14:30 Lunch Symposium: HydroZONES EU FP-7

Lunch Break & Industrial Exhibition

14:30 - 16:30 3D Models Biofabrication I ATMP Regulation

16:30 – 17:00 Coffee Break

17:00 - 19:00 Musculoskeletal

Tissue Engineering I Reprogramming &

Regeneration Future Perspectives in ATMP Regulation

19:00 Poster Presentation

with "Wine & Cheese"

Page 3: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Scientific Program at a Glance

2 4th International Conference "Strategies in Tissue Engineering" 2015

Thursday, June 11th

Franconia

Hall Room 11/12 Room 13

8:30 - 9:30 Plenary Lecture:

Early Regeneration & Stem Cells

9:30 - 10:00 Coffee Break

10:00 - 12:00 New Tools & Non-

Invasive Monitoring

Reprogramming & Mesenchymal

Stem Cells PhD Session

12:00 - 14:00 Lunch Symposium: IDEA EU FP-7

Lunch Break & Industrial Exhibition

14:00 - 16:00 Regenerative Materials II

Soft Tissue Engineering - Focus

on ECM Vascularization

16:00 - 16:30 Coffee Break

16:30 - 18:30 Musculoskeletal

Tissue Engineering II

Tissue Engineering of the Respiratory

System

3D Models – As Alternatives to Animal Models

19:00 Gala Dinner

Zehntscheune

Page 4: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Scientific Program at a Glance

4th International Conference "Strategies in Tissue Engineering" 2015 3

Friday, June 12th

Franconia

Hall Room 11/12 Room 13

9:00 - 10:00 Plenary Lecture:

Cell Based Therapies

10:00 - 10:30 Coffee Break

10:30 - 12:30 Clinical Application

& Monitoring Novel Preclinical

Strategies Biofabrication II

12:30 - 13:00 Award Ceremony &

Closing Remarks

13:00 Departure

Page 5: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg
Page 6: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Contents

4th International Conference "Strategies in Tissue Engineering" 2015 5

Scientific Program at a Glance 1

Introduction

Organizers and Organizing Committee 6

Welcome 8

Profile of the Würzburg Inititative Tissue Engineering 10

Scientific Program

Wednesday, June 10th 12

Thursday, June 11th 26

Friday, June 12th 41

Poster Presentation 47

Information

Sponsors and Industrial Exhibition 57

General Information & Venue 58

Map, Conference Location & Social Program 59

Floorplan Congress Center Würzburg 60

Page 7: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Organizers and Organizing Committee

6 4th International Conference "Strategies in Tissue Engineering" 2015

4th International Conference

“Strategies in Tissue Engineering“

June 10th – 12th, 2015

Würzburg, Germany

Organizers

Torsten Blunk (Vice-President WITE e.V.)

Frank Edenhofer

Jürgen Groll

Franz Jakob

Oliver Pullig

Heike Walles

Meike Haddad-Weber, PhD (Exec. Organizer)

Department of Tissue Engineering and Regenerative Medicine,

University Hospital of Würzburg

WITE - Würzburg Initiative Tissue Engineering e.V., www.wite.org

Muskuloskelettales Centrum Würzburg (MCW)

Page 8: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Organizers and Organizing Committee

4th International Conference "Strategies in Tissue Engineering" 2015 7

Conference Office

Imelda Mohn

Congress. Tourismus.

Wirtschaft.(CTW)

Am Congress Centrum

D-97070 Würzburg, Germany

Phone/Fax +49 (0) 931- 30 53 750

Email Imelda.Mohn@stadt.

wuerzburg.de

Contact Exhibition

Yvonne Beetz

medical event solutions GmbH

Bahnhofstr. 48

D-12305 Berlin, Germany

Mobile +49 (0) 151 – 5900 0095

Fax +49 (0) 30 -700 789 5 111

Email [email protected]

Organizing Committee

Torsten Blunk Lorenz Meinel

Regina Ebert Ulrich Nöth

Frank Edenhofer Oliver Pullig

Jürgen Groll Maximilian Rudert

Meike Haddad-Weber André F. Steinert

Franz Jakob Jörg Teßmar

Alexander Kübler Heike Walles

Rainer Meffert Thorsten Walles

Lunch Symposia

HydroZONES consortium, EU FP-7

IDEA consortium, EU FP-7

Page 9: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Welcome

8 4th International Conference "Strategies in Tissue Engineering" 2015

Welcome from the Organizers

Dear Colleagues and Friends,

We are honored to welcome you to the 4th International Conference

“Strategies in Tissue Engineering” in Würzburg, Germany. As at the previous

very successful conferences, we aim to bring together researchers from all over

the world to discuss the latest developments in the rapidly expanding

interdisciplinary field of Tissue Engineering and Regenerative Medicine.

We have invited more than 40 internationally well-known scientists to share

their knowledge and foster a lively discussion among all participants. The

scientific program takes into account the most recent developments and

trends of the field. Examples are biomaterials sessions focusing on

biofabrication and tissue printing as well as the design of immunomodulatory

materials, the growing importance of cell reprogramming for regenerative

medicine, new tools for non-invasive monitoring, 3D in vitro tissue models or

regenerative strategies in old age and multimorbidity. Also, clinical trials using

Advanced Therapy Medicinal Products (ATMPs) within the current regulatory

framework as well as the marketing authorization process will be covered. As

lunch symposia, we will present two FP7 EU projects, which are dealing with

engineering of zonal cartilage employing hierarchical hydrogels and printing

technologies, and the development of new tools and technologies for

identification, homing and monitoring of therapeutic cells for regenerative

medicine.

Again, it is one of our major goals to encourage young researchers and students

to get involved in the field and to participate at a top-class meeting for low

cost. Thus, we were trying to keep the conference fees as low as possible. For

Page 10: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Welcome

4th International Conference "Strategies in Tissue Engineering" 2015 9

the first time, we have organized a Ph.D. session to further stimulate early

stage networking and experience exchange.

Especially, we would like to thank all individuals involved in the conference

organization for their effort to put this meeting together and the industry and

sponsors for their financial support, both is crucial for a successful meeting.

Welcome to Würzburg,

Torsten Blunk

Frank Edenhofer

Jürgen Groll

Meike Haddad-Weber

Franz Jakob

Oliver Pullig

Heike Walles

Page 11: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

WITE ‐ Würzburg Initiative "Tissue Engineering" e.V.

10 4th International Conference "Strategies in Tissue Engineering" 2015

WITE The mission of the Würzburg Initiative "Tissue Engineering" e.V. (WITE), which was

founded in March 2003, is to facilitate the recognition of Würzburg as a national and

international center of excellence in tissue engineering research and education.

WITE e.V. also fosters economic development by promoting the growth of a regional

biotechnology industry rooted in the field of tissue engineering.

The goals of the WITE e.V. are:

• Promoting collaboration among Würzburg's leading health and academic

institutions

• Sponsorship of educational programs for students and professionals

• Funding of research with clear potential commercial impact

• Organization of international tissue engineering conferences

• Playing a leadership role in defining community strategies for regional

development

• Facilitating access to innovative technology transfer systems

Contact

Prof. Torsten Blunk, PhD (Vice-President WITE)

Head of Research

Department of Trauma, Hand, Plastic and Reconstructive Surgery

University of Würzburg

Oberdürrbacher Str. 6, 97080 Würzburg, Germany

Phone: +49 (0) 931 - 201 37115

Email: [email protected]

Page 12: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Scientific Program

4th International Conference "Strategies in Tissue Engineering" 2015 11

4th International Conference

"Strategies in Tissue Engineering"

Scientific Program

Page 13: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

12 4th International Conference "Strategies in Tissue Engineering" 2015

Opening 10:00 - 10:20

Franconia Hall

Chair: Jürgen Groll (Würzburg, Germany)

Welcome and opening remarks

W-001 Torsten Blunk (Würzburg, Germany), Vice-President WITE e.V. Heike Walles (Würzburg, Germany), Chair Department of Tissue Engineering and Regenerative Medicine, University Hospital of Würzburg Jürgen Groll (Würzburg, Germany) Chair Department for Functional Materials in Medicine and Dentistry, University of Würzburg

W-002 Alfred Forchel (Würzburg, Germany) President of the University of Würzburg

W-003 Matthias Frosch (Würzburg, Germany) Dean of the Medical Faculty, University of Würzburg

Page 14: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 13

Session 1: Plenary Lecture: 10:20 – 11:00 Materials

Franconia Hall

Chair: Jürgen Groll (Würzburg, Germany)

Plenary Lecture

O-001 Jeff Karp (Boston, USA) Towards accelerated medical innovation

30+10 min

Page 15: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

14 4th International Conference "Strategies in Tissue Engineering" 2015

Session 2: Regenerative Materials I 11:00 - 12:30

Franconia Hall

Chairs: Tal Dvir (Tel Aviv, Israel) Michiya Matsusaki (Osaka, Japan)

Keynote Lecture

O-002 Thomas Scheibel (Bayreuth, Germany) Bioengineering of silk proteins for biomedical applications

25+5 min

Oral Presentations

O-003 Michael Hacker (Leipzig, Germany) Oligomer-cross-linked gelatin biomaterials for biomedical applications

12+3 min

O-004 Ansgar Petersen (Berlin, Germany) Incorporation of calcium phosphate microparticles in highly orientated macroporous collagen scaffolds change the mechanism of bone defect healing

12+3 min

O-005 Kai Stuckensen (Würzburg, Germany) Cryostructured hierarchical scaffolds with zonal biochemistry and anisotropic porosity for biomimetic in situ cartilage tissue engineering

12+3 min

O-006 Burkhard Schlosshauer (Reutlingen, Germany) Capture antibodies to biofunctionalize vascular prosthesis

12+3 min

Page 16: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 15

Session 3: Bioreactor Technology 11:00 - 12:30 & Automatization

Room 11/12

Chairs: Michael Klos (Allershausen, Germany) Jan Hansmann (Würzburg, Germany)

Keynote Lectures

O-007 Juliane Hübner (Berlin, Germany) The multi-organ-chip platform – a new tool for predictive substance testing

18+3 min

O-008 Michael Klos (Allershausen, Germany) Dual arm robots – A new approach in lab automation

18+3 min

Oral Presentations

O-009 Sebastian Schürlein (Würzburg, Germany) Modular bioreactor platform for tissue engineering applications

10+2 min

O-010 Markus Meininger (Würzburg, Germany) Surface acoustic wave (SAW) analysis of fibronectin adsorption to ceramic and metallic surfaces on functionalized biosensor

10+2 min

O-011 Isabel Olmos Calvo (Vienna, Austria) Synovium-on-a-chip: Membrane trafficking as a means for the adaptive tissue response to inflammation in arthritis

10+2 min

O-012 Poh Soo Lee (Dresden, Germany) Bone tissue engineering: A biomimetic approach

10+2 min

Page 17: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

16 4th International Conference "Strategies in Tissue Engineering" 2015

Session 4: Healthy Aging (Epigenetics) 11:00 - 12:30

Room 13

Chairs: Franz Jakob (Würzburg, Germany) Oliver Bischof (Paris, France)

Keynote Lectures

O-013 Oliver Bischof (Paris, France) Cellular senescence: implications for health and disease

25+5 min

O-014 William Keyes (Barcelona, Spain) Cellular senescence is a regenerative process inducing stem cell fate and tumor formation

25+5 min

O-015 Wolfgang Wagner (Aachen, Germany) DNA methylation changes in aging and replicative senescence

25+5 min

Page 18: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 17

Lunch Symposium: 13:15 - 14:15 HydroZONES (EU FP-7)

Room 11/12

Chairs: Jürgen Groll (Würzburg, Germany)

Oral Presentations

O-016 Jürgen Groll (Würzburg, Germany) Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration

12+3 min

O-017 Anna Abbadessa (Utrecht, Netherlands) Novel hybrid photo-cross-linkable hydrogels for zonal 3D bioprinting

12+3 min

O-018 Thomas Böck (Würzburg, Germany) Chondromimetic polyglycidol-based hydrogels for MSC chondro-genesis

12+3 min

O-019 Emma Muinos-López (Pamplona, Spain) Ectopic implantation of osteochondral plugs into immunodeficient mice as a platform for biomaterial testing

12+3 min

Page 19: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

18 4th International Conference "Strategies in Tissue Engineering" 2015

Session 5: 3D Models 14:30 - 16:30

Franconia Hall

Chairs: Gudrun Dandekar (Würzburg, Germany) John Hickman (Paris, France)

Keynote Lectures

O-020 John Hickman (Paris, France) 3D Cancer models and imaging

25+5 min

O-021 Boris Holzapfel (Würzburg, Germany) Tissue engineered humanized models of cancer

25+5 min

Oral Presentations

O-022 Verena Grützner (Mainz, Germany) A three dimensional, full-thickness in vitro skin equivalent com-bining a prevascularized dermal and a stratified epidermal unit

12+3 min

O-023 Matthias Schweinlin (Würzburg, Germany) Development of an improved primary in vitro model of the human small intestine as alternative for cell line-based models

12+3 min

O-024 Mona Alzheimer (Würzburg, Germany) Novel tissue engineered human 3D infection models to study pathogenesis of Campylobacter jejuni and Helicobacter pylori

12+3 min

O-025 Darja Ivannikov (Karlsruhe, Germany) µ3DVasc: A blood vessel scaffold for the reconstruction of 3D blood-brain barrier in-vitro

12+3 min

Page 20: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 19

Session 6: Biofabrication I 14:30 - 16:30

Room 11/12

Chairs: Thomas Scheibel (Bayreuth, Germany) Heungsoo Shin (Seoul, Korea)

Keynote Lectures

O-026 Michiya Matsusaki (Osaka, Japan) Control of cell surfaces by LbL films for fabrication of 3D human tissue models

25+5 min

O-027 Gordon G. Wallace (Wollongong, Australia) Organic bionics: the need for 3D printing

25+5 min

Oral Presentations

O-028 Kristin Schacht (Bayreuth, Germany) Recombinant spider silk proteins can be used as new bioinks

12+3 min

O-029 Daniel Hägg (Gothenburg, Sweden) Using 3D bioprinting technology to spatially distribute chondrocytes and induced pluripotent stem cells in nanocellulose bioink

12+3 min

O-030 Vivian H.M. Mouser (Utrecht, Netherlands) Tailoring a gelatin methacrylamide and gellan hybrid hydrogel for

cartilage biofabrication

12+3 min

O-031 Alberto Rainer (Rome, Italy) Additive manufacturing of pluronic/alginate thermogels

12+3 min

Page 21: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

20 4th International Conference "Strategies in Tissue Engineering" 2015

Session 7: ATMP Regulation 14:30 - 16:30

Room 13

Chairs: Ralf Sanzenbacher (Langen, Germany) Oliver Pullig (Würzburg, Germany)

Keynote Lectures

O-032 Ralf Sanzenbacher (Langen, Germany) Centralized approval, hospital exemption and bedside practice: regulatory pathways for ATMP development from PEI’s view

25+5 min

O-033 Heiko von der Leyen (Hannover, Germany) Principles of the new European Clinical Trial Regulation EU 536/14

25+5 min

O-034 Timo Faltus (Leipzig, Germany) Cell-based therapies in point-of-care settings: therapy concepts between innovative personalized medicine and missing legal (ATMP) control?

25+5 min

O-035 Volker Scherhammer (Munich, Germany) Translation of cell-based gene therapy product into clinical phase II trial

25+5 min

Page 22: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 21

Coffee Break 16:30 – 17:00

Foyer

Page 23: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

22 4th International Conference "Strategies in Tissue Engineering" 2015

Session 8: Musculoskeletal 17:00- 19:00 Tissue Engineering I

Franconia Hall

Chairs: Rainer Meffert (Würzburg, Germany) Matha Murray (Boston, USA)

Keynote Lectures

O-036 Chris Evans (Rochester, USA) The clinical translation of osteoarthritis gene therapy

25+5 min

O-037 Wiltrud Richter (Heidelberg, Germany) Functional Tissue Engineering of articular cartilage: challenges and recent progress

25+5 min

Oral Presentations

O-038 Jessica Gabler (Heidelberg, Germany) Stage-specific modulation of miRNA expression during chondrogenic differentiation of human mesenchymal stromal cells

12+3 min

O-039 Benedikt Proffen (Boston, USA) Intra-articular injections of extracellular matrix-blood composite mitigates post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat knee

12+3 min

O-040 Jakob Sieker (Boston, USA) The molecular response to anterior cruciate ligament injury: Implications for tissue engineering therapies of injured joints

12+3 min

O-041 Liudmila Leppik (Frankfurt, Germany) Effect of electrical stimulation on amputated rat limb regeneration

12+3 min

Page 24: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 23

Session 9: Reprogramming 17:00- 19:00 & Regeneration

Room 11/12

Chairs: Frank Edenhofer (Würzburg, Germany) Franz Jakob (Würzburg, Germany)

Keynote Lectures

O-042 Jürgen Knoblich (Vienna, Austria) Modeling human brain development and disease in 3D culture

25+5 min

O-043 Matthias Lutolf (Lausanne, Switzerland) Title to be announced

25+5 min

Oral Presentations

O-044 Antje Appelt-Menzel (Würzburg, Germany) Differentiation of human multipotent and pluripotent stem cells to develop a human 3D in vitro blood brain barrier model

12+3 min

O-045 Solvig Diederichs (Heidelberg, Germany) Regulation of SOX9 in human induced pluripotent stem cells during multi-phase chondrogenic differentiation

12+3 min

O-046 Reem Al Hijailan (Würzburg, Germany) Differentiated induced pluripotent stem cells grown on xenogenic decellularized scaffold as a possible approach to circumvent vascularized xenograft rejection

12+3 min

O-047 Katharina Günther (Würzburg, Germany) Derivation and stabilization of a novel early neural precursor population from human embryonic tissue for biomedical applications

12+3 min

Page 25: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

24 4th International Conference "Strategies in Tissue Engineering" 2015

Session 10: Future Perspectives 17:00- 19:00 in ATMP Regulation

Room 13

Chairs: Martina Schüßler-Lenz (Langen, Germany) Hans-Georg Eckert (Mannheim, Germany)

Keynote Lectures

O-048 Martina Schüßler-Lenz (Langen, Germany) View from the committee for advanced therapies: challenges and progress

25+5 min

O-049 Matthias Eyrich (Würzburg, Germany) View from clinical application

25+5 min

O-050 Klaus Maleck (Reutlingen, Germany) ATMPs: An economic analysis

25+5 min

Page 26: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Wednesday June 10th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 25

Poster Presentation 19:00 - 21:00 with "Wine & Cheese"

Foyer

The poster session with "Wine & Cheese" (free of charge) starts at 19:00 at the Foyer of the Congress Center.

Please be available at your poster and ready to present it in the time from 19:00 – 21:00

During the poster presentation, the poster-prize-jury will go through the posters and will nominate the best posters of the conference. The winners will be announced at the closing session on Friday, June 12th.

Page 27: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Thursday June 11th, 2015

26 4th International Conference "Strategies in Tissue Engineering" 2015

Session 11: Plenary Lecture: 8:30 – 9:30 Early Regeneration & Stem Cells

Franconia Hall

Chair: Frank Edenhofer (Würzburg, Germany)

Plenary Lecture

O-051 Jean-Marc Lemaitre (Montpellier, France) iPSCs as a major opportunity to understand and cure age-related diseases

45+15 min

Page 28: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 27

Coffee Break 9:30 - 10:00

Foyer

Page 29: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Thursday June 11th, 2015

28 4th International Conference "Strategies in Tissue Engineering" 2015

Session 12: New Tools & 10:00 - 12:00 Non-invasive Monitoring

Franconia Hall

Chairs: Maike Windsberg (Saarbrücken, Germany) Jan Hansmann (Würzburg, Germany)

Keynote Lectures

O-052 Nicola Crosetto (Stockholm, Sweden) New tools for spatially resolved, multiplex molecular profiling of tumor heterogeneity

16+4 min

O-053 Andreas Beilhack (Würzburg, Germany) 3D high resolution light sheet fluorescence microscopy (LSFM) to map immune processes within tissues

16+4 min

O-054 Maike Windsberg (Saarbrücken, Germany) Confocal Raman microscopy as a non-invasive approach for the analysis of cells and human tissues

16+4 min

Oral Presentations

O-055 Laura Nebuloni (Zürich, Switzerland) Imaging strategies in tissue engineering

12+3 min

O-056 Verena Charwat (Vienna, Austria) Noninvasive and continuous monitoring of mesenchymal stem cell differentiation using impedance sensors in microfluidic devices

12+3 min

O-057 Elmar Hartmann (Berlin, Germany) New force tool for quantitative nano-mechanical measurements by atomic force microscopy

12+3 min

O-058 Martin Schöne (Berlin, Germany) Objective characterization of cartilage repair outcomes by 3D ultrasound biomicroscopy

12+3 min

Page 30: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 29

Session 13: Reprogramming & 10:00 - 12:00 Mesenchymal Stem Cells

Room 11/12

Chairs: Norbert Schütze (Würzburg, Germany) Wiltrud Richter (Heidelberg, Germany)

Keynote Lecture

O-059 Frank Edenhofer (Würzburg, Germany) Promises and denials of cellular reprogramming – Exploring novel reprogramming pathways to yield patient-specific cells for biomedical applications

25+5 min

Oral Presentations

O-060 Aleksandra Gornostaeva (Moscow, Russia) Immunomodulatory effect of multipotent mesenchymal stromal cells on T-cells under hypoxia

12+3 min

O-061 Philipp Schendzielorz (Würzburg, Germany) Adipose tissue-derived stem cell (ASC) application enhances the survival of spiral ganglion neurons in the impaired inner ear

12+3 min

O-062 Mathias Roth (Düsseldorf, Germany) Low oxygen increases CD44 expression in lacrimal gland derived mesenchymal stem cells

12+3 min

O-063 Andrea Niklaus (Würzburg, Germany) Role of the chromatin associated factors Bmi1 and Lsh in aging and osteogenesis of human mesenchymal stem cells

12+3 min

O-064 Olga Udartseva (Moscow, Russia) Gene expression of Wnt- and MAPK- signaling pathways in MSCs under hypoxic stress

12+3 min

O-065 Andreas Heider (Leipzig, Germany) Human mesenchymal stem cells from fresh and cryopreserved umbilical cord tissue: a comparison

12+3 min

Page 31: Scientific Program at a Glance - WITE.ORG - NEWS · 2015-06-01 · Scientific Program at a Glance 1 Introduction Organizers and Organizing Committee 6 Welcome 8 Profile of the Würzburg

Thursday June 11th, 2015

30 4th International Conference "Strategies in Tissue Engineering" 2015

Session 14: PhD Session 10:00 - 12:00

Room 13

Chairs: Heike Walles (Würzburg, Germany) Torsten Blunk (Würzburg, Germany)

Oral Presentation

O-066 Thomas Oliver (London, UK) Gap junctions communicate differentiation signals between human mesenchymal stromal cells

10+2 min

O-067 Maria Costanza Chiti (Bruxelles, Belgium) Allografting of murine ovarian follicles in a fibrin matrix: influence of follicle stage on graft outcome

10+2 min

O-068 Ute Mayer (Regensburg, Germany) Influence of cartilage explants on cocultured chondrocytes / mesenchymal stem cells

10+2 min

O-069 Eliane Hesse (Heidelberg, Germany) Bio-instructive hydrogel-systems for functional cartilage tissue engineering

10+2 min

O-070 Florian A. Formica (Zürich, Switzerland) An anti-inflammatory nanofiber-hydrogel composite for cartilage engineering

10+2 min

O-071 Laura Wistlich (Würzburg, Germany) A one-step approach for multimodal functionalization of electrospun nanofibers and their application for immune-regulatory surfaces

10+2 min

O-072 Simone Scholtes (Heidelberg, Germany) Molecular response of chondrocytes to dynamic compression in osteochondral tissue engineering constructs

10+2 min

O-073 Marion Straßer (Würzburg, Germany) Multifunctional nanoparticles for medical imaging

10+2 min

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Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 31

O-074 Susanne Christ (Würzburg, Germany) 3D-Printing of strontium-substituted magnesium phosphate scaffolds

10+2 min

O-075 Miriam Wiesner (Würzburg, Germany) Engineering of large-scale vascularized adipose tissue using decellularized porcine jejunal segments in vitro in a custom-made bioreactor system

10+2 min

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Thursday June 11th, 2015

32 4th International Conference "Strategies in Tissue Engineering" 2015

Lunch Break 12:00 - 14:00 Posters & Industrial Exhibition

Foyer

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Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 33

Lunch Symposium 12:30 - 14:00 IDEA (EU FP-7)

Room 11/12

Chair: Ulrich Pison (Berlin, Germany)

Oral Presentations

O-076 Ulrich Pison (Berlin, Germany) Tools for regenerative medicine

10 min

O-077 Maria Steinke (Würzburg, Germany) Biological impact of iron oxide nanoparticles on hMSC and interaction with a magnetic device

15+4 min

O-078 Annika Kasten (Rostock, Germany) Magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived mesenchymal stem cells

15+4 min

O-079 Karin Schütze (Bernried, Germany) Raman spectroscopy for non-invasive cell characterization

15+4 min

O-080 Piotr Religa (Stockholm, Sweden) Animal models for translational research in regenerative medicine

15+4 min

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Thursday June 11th, 2015

34 4th International Conference "Strategies in Tissue Engineering" 2015

Session 15: Regenerative 14:00 - 16:00 Materials II

Franconia Hall

Chairs: Paul Dalton (Würzburg, Germany) Gordon Wallace (Wollongong, Australia)

Keynote Lectures

O-081 Heungsoo Shin (Seoul, Korea) Guided bone regeneration by bio-functional electrospun nanofibers

25+5 min

O-082 Tal Dvir (Tel Aviv, Israel) Advanced biomaterials for mending broken hearts

25+5 min

Oral Presentations

O-083 Marjan Enayati (Vienna, Austria) Establishment of macrophage-fibroblast co-culture system for biocompatibility evaluation of biodegradable electrospun vascular grafts: In-vitro/in-vivo studies

12+3 min

O-084 Menglin Chen (Aarhus, Denmark) Fibrogenesis of hiPS-MSCs on a 3D ECM mimicking nanocomposite scaffold

12+3 min

O-085 Ingo Heschel (Herzogenrath, Germany) Development of microstructured collagen-based nerve guides for peripheral nerve regeneration

12+3 min

O-086 Angela Rossi (Würzburg, Germany) Functionalized electrospun nanofibers for the development of a three-dimensional skin model

12+3 min

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Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 35

Session 16: Soft Tissue Engineering 14:00 - 16:00 - Focus on ECM

Room 11/12

Chairs: Lauren Flynn (London, Canada) Petra Bauer-Kreisel (Würzburg, Germany)

Keynote Lectures

O-087 Michael Raghunath (Singapore) Tuning amount and microarchitecture of the extracellular microenvironment with macromolecular crowding accelerates in vitro tissue formation and unleashes intrinsic phenotypic potential in progenitor cells

25+5 min

O-088 Lauren Flynn (London, Canada) Mechanisms of ASC-mediated regeneration in tissue-specific decellularized matrices

25+5 min

Oral Presentations

O-089 Christiane Höfner (Würzburg, Germany) Extracellular matrix composition and dynamics during adipogenic differentiation of adipose-derived stem cells in three dimensional culture systems

12+3 min

O-090 Lukas Prantl (Regensburg, Germany) Platelet-rich plasma affects vitality, differentiation and gene expression of adipose-derived stem cells in vitro

12+3 min

O-091 Katharina Storck (Munich, Germany) Implanted adipose-derived stem cells improve engineered adipose tissue consisting of host-derived cells in pu-fibrin gel constructs

12+3 min

O-092 Jan-Thorsten Schantz (Munich, Germany) Breast reconstruction using computer aided design and biomanufacturing – towards engineering clinically relevant volumes of adipose tissue

12+3 min

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Thursday June 11th, 2015

36 4th International Conference "Strategies in Tissue Engineering" 2015

Session 17: Vascularization 14:00 - 16:00

Room 13

Chairs: Hala Zreiqat (Sydney, Australia) Raimund Horch (Erlangen, Germany)

Keynote Lectures

O-093 Hala Zreiqat (Sydney, Australia) Fabrication of novel highly bioactive 3D printed ceramic scaffolds for bone and cartilage regeneration

16+4 min

O-094 Raimund Horch (Erlangen, Germany) The role of vascularization in TE and Regenerative Medicine from a Plastic Surgeon´s point of view

16+4 min

O-095 Laura Schreiber (Würzburg, Germany) Computational imaging - A new tool for understanding tissue vascularization

16+4 min

Oral Presentations

O-096 Darja Ivannikov (Karlsruhe, Germany) µ3DVasc: A blood vessel scaffold for the reconstruction of 3D-tissues in vitro

12+3 min

O-097 Katharina Sondershaus (Munich, Germany) Vascularization of 3D scaffolds for the development of osseous constructs - Progress in Tissue Engineering

12+3 min

O-098 Anja Lode (Dresden, Germany) Functionalization of bone tissue engineering scaffolds with a central, VEGF-loaded depot for cell attraction

12+3 min

O-099 Stefanie Thoms (Hannover, Germany) Endothelial markers in the secretome of serum-deprived adipogenic stem cells

12+3 min

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Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 37

Coffee Break 16:00 - 16:30

Foyer

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Thursday June 11th, 2015

38 4th International Conference "Strategies in Tissue Engineering" 2015

Session 18: Musculoskeletal 16:30 - 18:30 Tissue Engineering II

Franconia Hall

Chairs: Maximilian Rudert (Würzburg, Germany) Andre Steinert (Würzburg, Germany)

Keynote Lectures

O-100 Martha Murray (Boston, USA) Bridge-Enhanced ACL Repair: Bench to Bedside

25+5 min

O-101 Dietmar Hutmacher (Brisbane, Australia) Large preclinical animal models a condition sine qua non in the translation from bone tissue engineering concepts from bench to bedside

25+5 min

Oral Presentations

O-102 Shorouk Fahmy Garcia (Rotterdam, Netherlands) Screening osteogenic and chemoattractant properties of follistatin, NELL1 and CCN2 on osteoprogenitor cells in vitro

12+3 min

O-103 Bettina Hafen (Würzburg, Germany) Physical contact between mesenchymal stem cells and endothelial progenitor cells induces distinct global gene expression patterns important for tissue regeneration

12+3 min

O-104 Elisabeth Seebach (Heidelberg, Germany) Aggravation of osteomyelitis in an orthopaedic implant-stabilized bone defect after mesenchymal stroma cell implantation

12+3 min

O-105 Froilán Granero-Moltó (Pamplona, Spain) A nonunion animal model to assess the role and mechanisms of action of mesenchymal progenitor cells in bone regeneration

12+3 min

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Thursday June 11th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 39

Session 19: Tissue Engineering of the 16:30 - 18:30 Respiratory System

Room 11/12

Chairs: Sean Hall (Bern, Switzerland) Thorsten Walles (Würzburg, Germany)

Keynote Lectures

O-106 Sean Hall (Bern, Switzerland) Modeling the functional role of lung tumor pericytes in non-small cell lung cancer in 3D

20+5 min

O-107 N.N. Title to be announced

15+5 min

Oral Presentations

O-108 Judit Pongracz (Pecs, Hungary) 3D lung model to study the effects of Wnts on drug transporter activity in non-small cell lung cancer

12+3min

O-109 Luis DaSilva (Frederick, USA) Pulmonary host responses and biomarker assessment to aerosolized burkholderia thailandensis in an in vitro lung model

12+3min

O-110 David Fecher (Würzburg, Germany) Development of an organotypic lung tumor model with a clinical read-out system

12+3min

O-111 Katharina Seidensticker (Würzburg, Germany) Investigations of pertussis toxins in a 3D in vitro model of the human respiratory mucosa

12+3min

O-112 Silke Schwarz (Ulm, Germany) Characterization of a migrative subpopulation of adult human nasoseptal chondrocytes with progenitor cell features and their potential for in vivo cartilage regeneration strategies

12+3min

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Thursday June 11th, 2015

40 4th International Conference "Strategies in Tissue Engineering" 2015

Session 20: 3D Models as Alternatives 16:30 - 18:30 to Animal Models

Room 13

Chairs: Samuel Constant (Plan-les-Ouates, Switzerland) Bart De Wever (Monte Carlo, Monaco)

Keynote Lectures

O-113 Samuel Constant (Plan-les-Ouates, Switzerland) The use of reconstructed 3D airway epithelium in drug development for respiratory diseases and chemical testing

20+5 min

O-114 Bart De Wever (Monte Carlo, Monaco) The use of 3D tissue models as alternatives to animal testing

15+5 min

Oral Presentations

O-115 Filomena Gioiella (Naples, Italy) A novel 3D cancer model as emerging tool for the investigation of cancer stroma remodeling

12+3min

O-116 Claudia Göttlich (Würzburg, Germany) A combined in silico and in vitro lung cancer model on a decellularized matrix for individualized drug response predictions

12+3min

O-117 Anne Baecker (Karlsruhe, Germany) Adjustable cryogel structures for the 3D cultivation of prostate cancer cells

12+3min

O-118 Christophe Mas (Geneva, Switzerland) A functional 3D human airway epithelium with tumors for in vitro lung cancer research

12+3min

O-119 Constanze Buhrmann (Munich, Germany) Alginate 3D model tumor microenvironment: a bridge to in vivo studies

12+3min

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Friday June 12th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 41

Session 21: Plenary Lecture 9:00 - 10:00 Cell-Based Therapies

Franconia Hall

Chair: Heike Walles (Würzburg, Germany)

Plenary Lecture

O-120 Julia Ino (Bruxelles, Belgium) Cell-based therapy for bone diseases

45+15 min

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Friday June 12th, 2015

42 4th International Conference "Strategies in Tissue Engineering" 2015

Coffee Break 10:00 - 10:30

Foyer

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Friday June 12th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 43

Session 22: Clinical Applications 10:30 - 12:30 & Monitoring

Franconia Hall

Chairs: Ulrich Nöth (Berlin, Germany) Oliver Pullig (Würzburg, Germany)

Keynote Lecture

O-121 Ulrich Nöth (Berlin, Germany) Adipose derived stem cells for osteoarthritis therapy

25+5 min

O-122 Felipe Prosper (Pamplona, Spain) Investigator initiated trials (IIT) of advanced therapy medicinal products

25+5 min

Oral Presentations

O-123 Cornelia Kasper (Vienna, Austria) Strategies for cultivating stem cells under physiological conditions

15+5 min

O-124 Karin Schütze (Bernried, Germany) Label-free cell analysis and quality assurance in 3D skin grafts using photonic fingerprinting®

15+5 min

O-125 Jakob Kreutner (Würzburg, Germany) Monitoring of AVN model in sheep using MRI and correlation with ex vivo µCT

15+5 min

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Friday June 12th, 2015

44 4th International Conference "Strategies in Tissue Engineering" 2015

Session 23: Novel Preclinical Strategies 10:30 - 12:30

Room 11/12

Chairs: Heike Walles (Würzburg, Germany) Julia Schüler (Freiburg, Germany)

Keynote Lectures

O-126 Eckhard Wolf (Munich, Germany) Genetically tailored pigs as novel preclinical animal models

25+5 min

O-127 Julia Schüler (Freiburg, Germany) Preclinical mouse models for oncology research: facing the challenge of modelling the tumor microenvironment

25+5 min

Oral Presentations

O-128 Lars Wallstabe (Würzburg, Germany) Engineered T cells modified to express a ROR1-specific chimeric antigen receptor (CAR) confer potent anti-tumor reactivity in pre-clinical tumor models

12+3 min

O-129 Maren Jannasch (Würzburg, Germany) Three-dimensional skin equivalents to investigate helminth invasion

12+3 min

O-130 Anja P. Ramme (Berlin, Germany) A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

12+3 min

O-131 Manuele Gori (Rome, Italy) A novel liver-on-chip device for studying nonalcoholic fatty liver disease

12+3 min

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Friday June 12th, 2015

4th International Conference "Strategies in Tissue Engineering" 2015 45

Session 24: Biofabrication II 10:30 - 12:30

Room 13

Chairs: Jos Malda (Utrecht, Netherlands) Jürgen Groll (Würzburg, Germany)

Keynote Lectures

O-132 Paul Dalton (Würzburg, Germany) Additive manufacturing with melt electrospinning writing

25+5 min

O-133 Jos Malda (Utrecht, Netherlands) Biofabrication of constructs for osteo-chondral repair

25+5 min

Oral Presentations

O-134 Michael Müller (Zürich, Switzerland) Hydroxyapatite containing inks for 3D bone bioprinting

12+3 min

O-135 Bapi Sarker (Erlangen, Germany) Development of oxidized alginate-gelatin hydrogels biofabrication

12+3 min

O-136 Julian Blaser (Munich, Germany) Approaches for fabrication of model tissues by bioprinting

12+3 min

O-137 Tomasz Jüngst (Würzburg, Germany) Melt electrospinning writing onto cylindrical collectors

12+3 min

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Friday June 12th, 2015

46 4th International Conference "Strategies in Tissue Engineering" 2015

Closing Remarks 12:30 - 13:00

Franconia Hall

Chair: Heike Walles (Würzburg, Germany)

Farewell

C-001 Torsten Blunk (Würzburg, Germany) Heike Walles (Würzburg, Germany) Jürgen Groll (Würzburg, Germany) Announcement of the poster prize winners and closing remarks

30 min

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Poster Presentations

4th International Conference "Strategies in Tissue Engineering" 2015 47

Poster Presentations P 1 - P 95

Foyer

The posters are presented at the foyer in front of Franconia Hall and can be visited during the whole conference. Poster set up is on Wednesday, June 10th, from 7:30 - 10:00. Suitable mounting material is available at the registration desk. A special poster session with "Wine & Cheese" will be held on Wednesday evening (June 10th), starting at 19:00 at the Foyer of the Congress Center. Please be available at your poster and ready to present it in the time from 19:00 – 21:00 During this poster presentation, the poster-prize-jury will go through the posters and will nominate the best posters of the conference. The winners will be announced in the closing session on Friday, June 12th. Posters have to be removed on Friday, June 12th, in the time from 13:00 - 14:00. Posters that have not been removed by 14:00 will be discarded.

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Poster Presentations

48 4th International Conference "Strategies in Tissue Engineering" 2015

Poster

P-001 Christian Lotz (Würzburg, Germany) Establishment of a non-contracting transparent in-vitro cross-linked collagen

P 1

P-002 Benjamin Kappler (Berlin, Germany) A microparticle suspension of human cardiac extracellular matrix for cytoprotection in myocardial cell therapy and tissue engineering

P 2

P-003 Susanne Koch (Würzburg, Germany) Photocatalytic luminescent TiO2/SiO2 nanoparticles

P 3

P-004 Raminder Singh (Erlangen, Germany) Alginate/Protein Hybrid Hydrogels: Effects on Human Vascular Cell Attachment and Growth

P 4

P-005 Enrique Martínez Campos (Madrid, Spain) Cell growth and controlled detachment over pseudo-double network hydrogels

P 5

P-006 Katrin Hurle (Erlangen-Nuremberg, Germany) Influence of 2-Hydroxethylmethacrylate on the hydration of a calcium phosphate cement

P 6

P-007 Julia Blöhbaum (Würzburg, Germany) Cysteine-functional Poly(2-alkyl-2-oxazoline)s via thiol–ene conjugation

P 7

P-008 Willi Smolan (Würzburg, Germany) Cysteine-functional polymers for conjugation of peptides

P 8

P-009 Sarah Bertlein (Würzburg, Germany) Surface modification of scaffolds prepared by melt electrospinning writing (MEW)

P 9

P-010 Susanne Feineis (Würzburg, Germany) Biologically functionalized gold nanoparticles for photo-thermal cell treatment

P 10

P-011 Ilona Zilkowski (Würzburg, Germany) Aptamer labelling of redox-sensitive nanogels for active tumour targeting

P 11

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Poster Presentations

4th International Conference "Strategies in Tissue Engineering" 2015 49

P-012 Theresa Christel (Würzburg, Germany) Differentiation of RAW 264.7 on calcium substituted struvite scaffolds

P 12

P-013 Martha Geffers (Würzburg, Germany) Dual setting calcium phosphate/fibroin cements

P 13

P-014 Tamara Aigner (Bayreuth, Germany) Controlled interaction between cells and engineered spider silk materials

P 14

P-015 Kiran Pawar (Bayreuth, Germany) recombinant spider silk scaffolds as guidance for neural cells

P 15

P-016 Tobias Weigel (Würzburg, Germany) Development of nanoelectrodes for cell stimulation and reduced foreign body reaction

P 16

P-017 Elise DeSimone (Bayreuth, Germany) Development of aqueous recombinant spider silk protein solutions for electrospinning

P 17

P-018 Susanne Koch (Würzburg, Germany) Stabilization of TiO2 nanoparticles in cell culture media

P 18

P-019 Tobias Schmitz (Würzburg, Germany) Nanoscale textured electrodes for seamless electronic-tissue interfaces

P 19

P-020 Verena Schill (Würzburg, Germany) Polyglycidol/hyaluronic acid based hydrogels for 3D bioplotting

P 20

P-021 Felix Hanßke (Berlin, Germany) Specific interface stabilization in composite materials via peptide-polymer conjugates for load bearing tissue applications

P 21

P-022 Rainer Detsch (Erlangen, Germany) Investigation of a co-culture system of osteoblast- and osteoclast-progenitor cells for biofabrication approaches

P 22

P-023 Gernot Hochleitner(Würzburg, Germany) Additive manufacturing of ultrafine thermoplastic filaments via melt electrospinning writing

P 23

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Poster Presentations

50 4th International Conference "Strategies in Tissue Engineering" 2015

P-024 Freia Schmid (Würzburg, Germany) Automated assessment of the barrier function of in vitro epidermal models using a dual-arm robotic system

P 24

P-025 Claudia Kleinhans (Stuttgart, Germany) Perfusion bioreactor system for efficient generation of cell-loaded bone substitute materials addressing critical size bone defects

P 25

P-026 Rico Brendtke (Würzburg, Germany) Plastic compression for generating optimized in vitro skin equivalents

P 26

P-027 Alexander Dulebo (Karlsruhe, Germany) Investigating cell and tissue mechanics by atomic force microscopy

P 27

P-028 Joachim Schrauth (Würzburg, Germany) Comparison of multiple quantitative MRI parameters for characterization of the goat cartilage in an ongoing osteoarthritis: dGEMRIC, T1ρ and sodium

P 28

P-029 Marta Legacz (Berlin, Germany) Cell labelling strategies for MPI/MRI tracking

P 29

P-030 Olga Udartseva (Moscow, Russia) Low-fluence photodynamic treatment modifies functional activity of mesenchymal stromal cells

P 30

P-031 Franziska Ehlicke (Würzburg, Germany) Non-invasive analysis of articular cartilages zonal structure by Raman Spectroscopy

P 31

P-032 Theresa Hügen (Würzburg, Germany) Applicability of Raman spectroscopy for the analysis of therapeutic effects of anti-tumor drugs

P 32

P-033 Corinna Moll (Würzburg, Germany) Integration of primary enteric glial cells in intestinal tissue models in vitro

P 33

P-034 Szymon Kurdyn (Würzburg, Germany) Wound-healing studies on immunocompetent full-thickness skin equivalents

P 34

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Poster Presentations

4th International Conference "Strategies in Tissue Engineering" 2015 51

P-035 Andrea Schwab (Würzburg, Germany) Ex vivo osteo-chondral organ culture

P 35

P-036 Sarada Devi Ramachandran (Heidelberg, Germany) In vitro generation of functional liver organoid-like structures using adult human cells

P 36

P-037 Anup J. Shirley (Würzburg, Germany) Investigating effects of nanodiamonds on tumor cells

P 37

P-038 Franziska Schmitt (Würzburg, Germany) A 3D human lung tumor test system with invasion and induction of EMT by TGF-β1 for drug testing in advanced tumor stages

P 38

P-039 Rainer Detsch (Erlangen, Germany) Behaviour of tumour cells in 3D-biofabricated hydrogel based constructs

P 39

P-040 Lena Müller (Würzburg, Germany) Establishment of a 3D mamma carcinoma test system on a decellularized scaffold

P 40

P-041 Florentin Baur (Würzburg, Germany) Targeted therapies of two different BRAF-mutated cell lines and the establishment of a 3D tumor model on the basis of a decellularized intestinal matrix

P 41

P-042 Skadi Lau (Hannover, Germany) Human adipose tissue-derived mesenchymal stem cells promote capillary formation of peripheral blood outgrowth endothelial cells in autologous fibrin gels

P 42

P-043 Melva Suarez Muñoz (Würzburg, Germany) Study of the effect of collagenous microcarriers on the vasculogenic potential of endothelial cells obtained from different sources

P 43

P-044 Holger Kirch (Würzburg, Germany) Development of a large, artificially vascularized, three dimensional fibrous scaffold with fitting bioreactor system

P 44

P-045 Martin Oberringer (Homburg, Germany) 2D and 3D endothelial cell-pericyte co-cultures as basic models for soft tissue related angiogenesis

P 45

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Poster Presentations

52 4th International Conference "Strategies in Tissue Engineering" 2015

P-046 Carolin Beck (Würzburg, Germany) Human atrial appendages: an autologous cell source for vascularized humanized collagen scaffolds

P 46

P-047 Ronny Schulz (Leipzig, Germany) Is there a lack of evidence with stem cell therapy in the knee

P 47

P-048 Christian Schmidt (Leipzig, Germany) Evaluation of a GMP-compliant production process of a mesenchymal stem cell-based articular cartilage therapy

P 48

P-049 Marco Wallenborn (Leipzig, Germany) Genetic stability within chondrocyte cultures in potential cell therapy

P 49

P-050 Anna Schliermann (Würzburg, Germany) Working towards the maintenance of articular chondrocytes in vivo

P 50

p-051 Priyanka Dwivedi (Goa, India) Study of different delivery modes of chondroitin sulphate using microspheres and cryogel scaffold for application in cartilage tissue engineering

P 51

P-052 Tobias Schneider (Berlin, Germany) dPGS-based injectable hydrogels for cartilage repair

P 52

P-053 Cordula Grüttner (Rostock, Germany) Positive impact of IGF-1 coupled nanoparticles on the differentiation potential of human chondrocytes cultured on collagen scaffolds and in 3D pellet cultures

P 53

P-054 Martin Krähnke (Würzburg, Germany) Impact of hypoxia on extracellular matrix-modulating enzymes during chondrogenesis of bone marrow-derived stromal cells

P54

P-055 Martin Krähnke (Würzburg, Germany) Towards osteochondral tissue engineering utilizing 3D silk fibroin scaffolds

P 55

P-056 Anne Bernhardt (Dresden, Germany) Biphasic scaffolds from marine collagens support simultaneous osteogenic and chondrogenic differentiation of human mesenchymal stem cells

P 56

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Poster Presentations

4th International Conference "Strategies in Tissue Engineering" 2015 53

P-057 Franziska Ehlicke (Würzburg, Germany) Bi-layered structured collagenous biomaterials for bone and cartilage tissue engineering in a 3D bioreactor system

P 57

P-058 Solange Le Blanc (Würzburg, Germany) Effect of fibroblast growth factor 1 and 2 on adipogenesis of human bone marrow stromal cells in 3D collagen gels

P 58

P-059 Meike Simann (Würzburg, Germany) Fibroblast growth factor (FGF) 1 impedes adipogenic and osteogenic differentiation and conversion of human bone marrow stromal cells via FGF receptor 1 and extracellular-signal regulated kinases 1/2 signaling

P 59

P-060 Dominik Egger (Vienna, Austria) Effects of physiological fluid shear stress in the osteogenic differentiation of human stem cells

P 60

P-061 Sahba Mobini (Frankfurt, Germany) The effect of direct current electrical stimulation on osteogenic differentiation of rat bone marrow- vs. adipose-derived mesenchymal stem cells

P 61

P-062 Ana Santos-Coquillat (Madrid, Spain) Evaluation of osteoclastogenic process on biologically activated chitosan films

P 62

P-063 Claudia Siverino (Würzburg, Germany) Site-directed Immobilization of BMP-2 and Noggin inhibitory peptides onto collagen beads for bone regeneration

P 63

P-064 Barbara Tabisz (Würzburg, Germany) Site-specific immobilization of modified BMP-2 on polymeric beads for improved bone regeneration

P 64

P-065 Davide Confalonieri (Würzburg, Germany) A new in-vitro bone formation assay starting from a collagen-based granular scaffold

P 65

P-066 Dirk Henrich (Frankfurt, Germany) Influence of the isolation procedure and the tissue site on osteogenic function and gene expression in human MSC in vitro

P 66

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Poster Presentations

54 4th International Conference "Strategies in Tissue Engineering" 2015

P-067 Stefanie Hölscher-Doht (Würzburg, Germany) Bone substitutes for stabilization of tibial head depression fractures - a biomechanical analysis

P 67

P-068 Sönke Frey (Würzburg, Germany) Do gastric bypass operations alter bone quality? Biomechanical investigation in a rat model

P 68

P-069 Ludwig Körber (Erlangen-Nürnberg, Germany) Decellularized meniscus as a replacement for meniscal tissue - an ovine model

P 69

P-070 Cvetan Popov (Munich, Germany) Analyses of tendon stem/progenitor cells on collagen I gel carrier for tendon tissue engineering

P 70

P-071 Sebastian A. Müller (Basel, Switzerland) The synergistic effect of bFGF, BMP12, and TGFβ1 on tendon healing in a rat model

P 71

P-072 Sebastian A. Müller (Basel, Switzerland) Collagen type I augmented Achilles tendon repair in a rat model

P 72

P-073 Christiane Höfner (Würzburg, Germany) Collagen synthesis as a regulatory factor of adipogenic differentiation of human adipose-derived stem cells in a three-dimensional context

P 73

P-074 Katharina Wittmann (Würzburg, Germany) Engineering vascularized adipose tissue using the stromal vascular fraction and fibrin hydrogels

P 74

P-075 Kristina Spaniol (Würzburg, Germany) Decellularized human corneal limbus for limbal reconstruction

P 75

P-076 Holger Koch (Leipzig, Germany) Tissue engineered esophageal grafts: Influence of crosslinking and surgical procedures on esophageal replacement in pigs

P 76

P-077 Alan Palus (Würzburg, Germany) Biocompatibility of collagen I coated airway stents in a large animal model

P 77

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Poster Presentations

4th International Conference "Strategies in Tissue Engineering" 2015 55

P-078 Jörn Probst (Würzburg, Germany) Development and evaluation of new therapeutic methods for chronic skin diseases

P 78

P-079 Petra Bischoff (Pforzheim, Germany) Standardization in regenerative medicine – friend or foe?

P 79

P-080 Polina Bobyleva (Moscow, Russia) Multipotent mesenchymal stromal cells with elevated intracellular ROS are susceptible to activated allogeneic peripheral blood mononuclears

P 80

P-081 Luisa M. Schäck (Hannover, Germany) CD24 as a switch between pro-inflammatory and anti-inflammatory phenotype in MSCs

P 81

P-082 Konstantin Dergilev (Moscow, Russia) Cardiac stem cell based cell sheets for the treatment of myocardium infarction

P 82

P-083 Yuri A. Bellido-Reyes (Madrid, Spain) Expanded autologous adipose-derived mesenchymal stem cells for the bronchoscopic treatment of bronchopleural fistula: a case report

P 83

P-084 Chi-fen Hsieh (Munich, Germany) Scleraxis-overexpressing bone marrow-derived mesenchymal stem cells compared to tendon stem/progenitor cells for tendon tissue engineering: in vitro and in vivo analyses

P 84

P-085 Nasser Alqhtani (London, UK) Small dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface In vitro

P 85

P-086 Constanze Buhrmann (Munich, Germany) Chondrogenic differentiation in mesenchymal stem cells through Resveratrol/SIRT1 pathway

P 86

P-087 Kathrin Hahn (Würzburg, Germany) Differentiation behavior of hMSCs on geometrically defined 3D fiber scaffolds

P 87

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Poster Presentations

56 4th International Conference "Strategies in Tissue Engineering" 2015

P-088 Sabine Wilhelm (Würzburg, Germany) In vitro differentiation of murine embryonic stem cells into intestinal cells

P 88

P-089 Sebastian Schürlein (Würzburg, Germany) An engineered 3D myocard model of human iPS-derived cardio-myocytes on small intestinal submucosa scaffold

P 89

P-090 Daniela Zdzieblo (Würzburg, Germany) Establishment of a 3D culture system based on a porcine-derived biological scaffold to differentiate human ips cells into pancreatic β-cells

P 90

P-091 Markus Mühlemann (Würzburg, Germany) Establishment of a transcription factor-based transdifferentiation assay to drive intestinal stem cells into pancreatic lineage cells

P 91

P-092 Reem Al Hijailan (Würzburg, Germany) Optimizing protocols for porcine heart decellularization and potential establishment of porcine induced pluripotent stem cells

P 92

P-093 Karl-Philipp Kienle (Würzburg, Germany) Cell-assisted lipotransfer (CAL) for vocal fold augmentation - a rabbit model

P 93

P-094 Meltem Avci-Adali (Tübingen, Germany) Synthetic modified mRNA-induced production of proteins in cells

P 94

P-095 Philipp Wörsdörfer (Würzburg, Germany) Genetic modulation of gap junctional communication to study the impact of cell-cell communication on stem cell differentiation

P 95

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Sponsors & Exhibitors

4th International Conference "Strategies in Tissue Engineering" 2015 57

We thank all sponsors and exhibitors

for their financial and scientific support.

Sponsors & Exhibitors

Biotechnology Journal, Wiley-VCH D-69469 Weinheim, Germany

Fraunhofer Translationszentrum TZKME D-97070 Würzburg, Germany

gempex GmbH D-68219 Mannheim, Germany

Paul Hartmann D-89522 Heidenheim, Germany

TOPASS GmbH D-12205 Berlin, Germany

Carl Zeiss Microscopy GmbH D-07745 Jena, Germany

CellSystems - Biotechnologie Vertrieb GmbH

D-53842 Troisdorf, Germany

CellTool GmbH D-82327 Tutzing, Germany

Corning GmbH D-65189 Wiesbaden, Germany

Cygenia GmbH D-52078 Aachen, Germany

Dunn Labortechnik GmbH D-53567 Asbach, Germany

EnvisionTEC GmbH D-45968 Gladbeck, Germany

Evonik D-45128 Essen, Germany

Fraunhofer Translationszentrum TZKME D-97070 Würzburg, Germany

gempex GmbH D-68219 Mannheim, Germany

German Stell Cell D-13125 Berlin, Germany

GeSim mbH D-01454 Großerkmannsdorf, Germany

Greiner Bio-One GmbH D-72636 Frickenhausen, Germany

IGZ Würzburg D-97076 Würzburg, Germany

LGC Standards GmbH D-46485 Wesel, Germany

LifeTec Group B.V. NL-5612 AZ Eindhoven, Netherlands

Maco Pharma International GmbH D-63225 Langen, Germany

Miltenyibiotec D-51429 Berg. Gladbach, Germany

Nanosurf GmbH D-63225 Langen, Germany

PeproTech GmbH D-22081 Hamburg, Germany

Precipoint D-85354 Freising, Germany

PromoCell GmbH D-69126 Heidelberg, Germany

regenHU Ltd. CH-1690 Villaz-St-Pierre, Switzerland

Sysmex Suisse AG CH-8810 Horgen, Switzerland

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Venue

58 4th International Conference "Strategies in Tissue Engineering" 2015

Venue

Congress Center Würzburg (CCW) Pleichertorstraße 5 97070 Würzburg

Registration Desk and Contact

The registration desk is open on Tuesday, June 9 from 16:00 - 19:00 Wednesday, June 10 from 07:30 - 18:00 Thursday, June 11 from 07:30 - 18:00 Friday, June 12 from 07:30 - 12:00 In the case of urgent questions out of the hours please contact the telephone hotline: Phone & Fax: 0931 - 30 53 750

Poster Presentation

Posters will be presented at the foyer in front of Franconia Hall. Poster set up is on Wednesday, June 10th, from 7:30 - 10:00. Suitable mounting material is available at the registration desk. While there is a dedicated poster session on Wednesday evening, 19:00 - 21:00, posters can be visited throughout the whole conference. Posters have to be removed on Friday, June 12th, in the time from 13:00 - 14:00. Posters which have not been removed by 14:00 will be discarded.

Getting around in Würzburg

A city map is included in your conference bag for convenient orientation and plenty of suggestions for after conference activities. We highly recommend walking within downtown Würzburg, as most places of interest can be reached within 15 min at most. Otherwise, buses and streetcars are available with single and 24-hour-tickets, starting from 1.70 € / 3.00 €, depending on the area covered. Tickets can be purchased at the office in front of the train station or from ticket machines at most of the bus and streetcar stations. There is a bus stop in front of the Congress Center and streetcar lines 2 and 4 have stops nearby.

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Map, Conference Location & Social Program

4th International Conference "Strategies in Tissue Engineering" 2015 59

Map of Würzburg Downtown

1. Congress Center and Hotel Maritim 2. City Hall 3. Würzburg Residence 4. Train Station 5. Zehntscheune, Juliusspital

Social Program

Wednesday, June 10th Location

Poster session with "Wine & Cheese" at the Congress Center 1

Thursday, June 11th

Gala Dinner at the Zehntscheune, Juliusspital 5

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Floorplan

60 4th International Conference "Strategies in Tissue Engineering" 2015

Industrial and Scientific Exhibition Foyer

Exhibitors Booth

Maco Pharma International GmbH 1

GeSim mbH 2

Dunn Labortechnik GmbH 3

Precipoint 4

Nanosurf GmbH 5

Cygenia GmbH 6

German Stell Cell

6

IGZ Würzburg

6

Evonik 7

regenHU Ltd. 8

Carl Zeiss Microscopy GmbH 9

EnvisionTEC GmbH 10

PromoCell GmbH 11

Sysmex Suisse AG 12

LifeTec Group B.V. 13

CellTool GmbH 14

Fraunhofer Translationszentrum Würzburg 15+20

PeproTech GmbH 16

Miltenyibiotec 17

LGC Standards GmbH 18

Corning GmbH 19

Greiner Bio-One GmbH 21

gempex GmbH 22

CellSystems - Biotechnologie Vertrieb GmbH 23

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Floorplan

4th International Conference "Strategies in Tissue Engineering" 2015 61

Franconia

Hall

Rooms 10-13 (upstairs)

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Notes

62 4th International Conference "Strategies in Tissue Engineering" 2015

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Floorplan

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