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NATURE MEDICINE VOLUME 10 | NUMBER 8 | AUGUST 2004 759 EDITORIAL C ondoms are ineffectiv e in the fight against AIDS. Abortion incr eases the risk of breas t cancer . An emerge ncy contra- ceptive, recommended as safe and effect ive by two inde- pendent scientific advisory panels, is not appr oved f or over - the-counter status in the United States. These are just a few of the positions the current US administra- tion has taken, in each case ignoring scientific evidence to the con- trary. It arrived at these conclusions by either disbanding scienti fic advisory committees or packing them with candidates selected for political , rather than scient ific, reasons. It has restricted fe deral scientists’ ability to talk freel y with the media and with their col- leagues. Most r ecently , it announced that the US Department of Health and Human Services (HHS) would determine which fed- eral resea rcher s can participat e in scientifi c panels of the W orld Health Organization (WHO). When a country as powerful as the United States makes deci- sions, however , the effects ar e felt f ar beyond it s borders. That was evident at the XV International A IDS Conference, held in J uly in Bangkok. The conference attracted nearly 20 ,000 delegates from 160 countries, but a new HHS pol icy restricted t he number of US federal scientists to fewer than 50 (  Nat. Me d. 10, 657; 2004). Because the policy was announced after many researchers had made plans t o attend the conference, dozens of sessions—includ- ing sessions where US scientists were supposed to train researchers from developing countries in grant writing and designing clinical trials—were canceled. The biannual AIDS c onference is one of only a few meetings of its scale that allow scientists and others who work with patients in poorer countries access t o such ex pertise. The HHS has cited travel costs to Bangkok as the reason for the small cont ingent. But the agency did not respond to offers of financial assistance fr om conference organizers and denied permission to attend the con- ference to a federal researcher whose trip would have been paid for by a highly visible journal. Even apart from the conferenc e, the HIV/AIDS field represents perhaps the most egregious of the Bush administration ’s sc ientific misst eps. In Janua ry 2003, Pres ident Bus h pledged $1 5 billio n over five y ears for the fight against HIV/AIDS. The plan heavily promotes the ABC’ approach of abstinence, monogamy and con- doms—for some high-risk groups—to prevent HIV transmis- sion, and ea rmarks a thi rd o f the f unds for abstin ence -only programs. In practic e, however , the use o f condoms has been marginalize d or dismissed alt ogether. For instance, guidelines published on 16 June by the US Centers for Disease Control and Prevention require organizations that promote HIV prevention and receive federal funds—even if the funds are not used for those preventi on programs—to include information on the “lack of effective ness of condom use. As many e xperts at the conf erence noted, women and girls in the developing world often do not have the choice to abstain, and condoms offer them the best available protect ion. Bush’ s AIDS plan also prohibit s use of the funds to buy generic versions of antiretroviral drugs. Officials hav e said that the policy is in place because the US Food and Drug Administration has not approved the generic drugs as safe and effective. However , these drugs have been ratified b y the WH O, which uses standard s endorsed by many international bodies including the Global Fund to Fight AIDS, T uberculosis and Malaria, the W orld Bank and Médecins Sans Frontières. To make decisions that pander to conservative constituents when mil lions of liv es are at stak e is uncons ciona ble. Last yea r alone, 3 million people died of AIDS-related causes and 5 million people became infected with HIV,more than in any previous year, according to a report by the Joint United Nations Programme on HIV/A IDS. The numb er of infec tions is su rging in Asia, Easte rn Europe and even in the United States. At the Bangkok meeting, activists expressed their anger by dog- ging US officials at nearly ev ery session, booing them at mentions of abstinence , carrying p oster s that de clar ed “Science, not pol i- tics” and chanting “No more lies.” But such histrionics are better left to activists. What can scien- tists do to change the administration’ s attitude to science? On 8 July , more than 4,000 scientists, including 48 N obel Prize winners and 12 7 member s of the US Nat ional A cadem y of Sciences, sent a state ment to the Bush admi nistration, accusing it of manipulating and suppressing science to further its political agenda. The same statement had also been sent t o the administra- tion in February by 62 prominent scientists. On both occasions, officials dismissed the letter as wrong and misleading. Previous administrations have generally been more responsive to the concer ns of acti vists and scient ists. But only conse rvative groups have the attention of those now in comm and. Writing let- ters that garner media coverage is a good start to bringing the problems out into t he open. But it is not enough. Scientists must band together and v oice their dissent. Those outside federal agencies must align with those within and support them in resistin g the admin istrat ion ’s polic ies. Most of all, scien- tists must not let the adm inistration silence their prot ests. What they must do—and continue doing until they are heard—is loudly and clearly counter the misguided policies with evidence- based arguments. Without r esorting to chanting or posters, scien- tists must still find their way to demand,“Science, not politics. Science, not politics    ©    2    0    0    4    N   a    t   u   r   e    P   u    b    l    i   s    h    i   n   g    G   r   o   u   p    h    t    t   p   :    /    /   w   w   w  .   n   a    t   u   r   e  .   c   o   m    /   n   a    t   u   r   e   m   e    d    i   c    i   n   e

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NATURE MEDICINE VOLUME 10 | NUMBER 8 | AUGUST 2004 759

E D I T O R I A L

Condoms are ineffective in the fight against AIDS.Abortionincreases the risk of breast cancer. An emergency contra-ceptive, recommended as safe and effective by two inde-

pendent scientific advisory panels, is not approved for over-the-counter status in the United States.

These are just a few of the positions the current US administra-tion has taken, in each case ignoring scientific evidence to the con-trary.It arrived at these conclusions by either disbanding scientificadvisory committees or packing them with candidates selectedfor political, rather than scientific, reasons. It has restricted federal

scientists’ ability to talk freely with the media and with their col-leagues. Most recently, it announced that the US Department of Health and Human Services (HHS) would determine which fed-eral researchers can participate in scientific panels of the WorldHealth Organization (WHO).

When a country as powerful as the United States makes deci-sions, however, the effects are felt far beyond its borders.That wasevident at the XV International AIDS Conference,held in July inBangkok. The conference attracted nearly 20,000 delegates from160 countries,but a new HHS policy restricted the number of USfederal scientists to fewer than 50 ( Nat. Med. 10, 657; 2004).Because the policy was announced after many researchers hadmade plans to attend the conference,dozens of sessions—includ-

ing sessions where US scientists were supposed to trainresearchers from developing countries in grant writing anddesigning clinical trials—were canceled.

The biannual AIDS conference is one of only a few meetings of its scale that allow scientists and others who work with patients inpoorer countries access to such expertise. The HHS has citedtravel costs to Bangkok as the reason for the small contingent. Butthe agency did not respond to offers of financial assistance fromconference organizers and denied permission to attend the con-ference to a federal researcher whose trip would have been paidfor by a highly visible journal.

Even apart from the conference, the HIV/AIDS field representsperhaps the most egregious of the Bush administration’s scientific

missteps. In January 2003, President Bush pledged $15 billionover five years for the fight against HIV/AIDS. The plan heavily promotes the ‘ABC’ approach of abstinence,monogamy and con-doms—for some high-risk groups—to prevent HIV transmis-sion, and earmarks a third of the funds for abstinence-only programs.

In practice, however, the use of condoms has been marginalizedor dismissed altogether. For instance,guidelines published on 16June by the US Centers for Disease Control and Preventionrequire organizations that promote HIV prevention and receive

federal funds—even if the funds are not used for those preventionprograms—to include information on the “lack of effectiveness of condom use.” As many experts at the conference noted, womenand girls in the developing world often do not have the choice toabstain, and condoms offer them the best available protection.

Bush’s AIDS plan also prohibits use of the funds to buy genericversions of antiretroviral drugs.Officials have said that the policy is in place because the US Food and Drug Administration has notapproved the generic drugs as safe and effective. However, thesedrugs have been ratified by the WHO, which uses standards

endorsed by many international bodies including the GlobalFund to Fight AIDS, Tuberculosis and Malaria, the World Bankand Médecins Sans Frontières.

To make decisions that pander to conservative constituentswhen millions of lives are at stake is unconscionable. Last yearalone, 3 million people died of AIDS-related causes and 5 millionpeople became infected with HIV,more than in any previous year,according to a report by the Joint United Nations Programme onHIV/AIDS. The number of infections is surging in Asia, EasternEurope and even in the United States.

At the Bangkok meeting,activists expressed their anger by dog-ging US officials at nearly every session, booing them at mentionsof abstinence, carrying posters that declared “Science, not poli-

tics”and chanting “No more lies.”But such histrionics are better left to activists.What can scien-

tists do to change the administration’s attitude to science?On 8 July, more than 4,000 scientists, including 48 Nobel Prize

winners and 127 members of the US National Academy of Sciences, sent a statement to the Bush administration, accusing itof manipulating and suppressing science to further its politicalagenda. The same statement had also been sent to the administra-tion in February by 62 prominent scientists. On both occasions,officials dismissed the letter as wrong and misleading.

Previous administrations have generally been more responsiveto the concerns of activists and scientists. But only conservativegroups have the attention of those now in command. Writing let-

ters that garner media coverage is a good start to bringing theproblems out into the open. But it is not enough.

Scientists must band together and voice their dissent. Thoseoutside federal agencies must align with those within and supportthem in resisting the administration’s policies. Most of all, scien-tists must not let the administration silence their protests. Whatthey must do—and continue doing until they are heard—isloudly and clearly counter the misguided policies with evidence-based arguments.Without resorting to chanting or posters,scien-tists must still find their way to demand,“Science, not politics.”

Science, not politics

   ©

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