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ISSN 0036-807531 JULY 1992VOLUME 257NUMBER 5070
AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE
NEWS & COMMENT
New Virus Reports Rile AIDS Meeting 604«j)~Progress on Other Fronts
Human SIV Infections Suspected 606
Germany: Astrophysics Institute at Risk 606
Bad News on Second-Hand Smoke 607
Frustrated EMBL Chief Resigns 607
A Scramble for Data on Arctic 608Radioactive Dumping
,eIAn NSF Survey Rattles Some Nerves 609
RESEARCH NEWSTrapping Particles of Darkness 610
A Match Made in Laser Heaven 611
The Earliest Mass Extinction? 612
Forcing the Evolution of an RNA r 613Enzyme in the Test Tube
Adhesion Protein Studies Provide New ° 614Clue to Metastasis
SPECIAL NEWS REPORTCONFLICTS OF INTEREST
Confusion on the Cutting Edge 616Joumal-istic Guidelines * Not Merely Academic
When Does Intellectual Passion Become 620Conflict of Interest?Sex on the Brain * The Perils of a Deeply HeldPoint ofView * Small Comets/Big Flap
NSF Deals With Conflicts Every Day 624
Intellectual Conflicts-Boon or Bust? 624
Conflicting Views: The Readers Respond 625
PERSPECTIVEThe Logic of Cell Division in the Life 626Cycle of YeastC. J. Gimeno and G. R. Fink
--------
Structural Processes at Slow-Spreading 627Ridges
J. C. Mutter and J. A. Karson
DRAAAS Board of Dire
Leon M. Lederman FlorenceRetiring President, Alan SchrChairman Jean'ne M
F. Sherwood Rowland Chang-LirPresident Warren M
Eloise E. ClarkPresident-elect William T.
Mary Ellen Avery TreasurFrancisco J. Ayala Richard SRobert A. Frosch Erecut
aCtors BmBP. Haseltineiriesheimd. Shreevein TenA. Washington
r.GoldenirerNicholson
tive Officer
John AbelsonFrederick W. AltDon L. AndersonStephen J. BenkovicDavid E BloomFloyd E. BloomHenry R. BoumeJames J. BullKathryn CalameC. Thomas CaskeyDennis W. Choi
John M. CoffinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. FearonHarry A. FozzardVictor R. FuchsTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. Glass
oard of Reviewing Editorsii iiiiiiiiii
Stephen P. Goff Mortimer MishkinCorey S. Goodman Roger A. NicollStephen J. Gould William H. Orme-Johnson Ill
Ira Herskowitz Stuart L PimmEric F. Johnson Yeshayau PockerStephen M. Kosslyn Dennis A. PowersMichael LaBarbera Ralph S. QuatranoCharles S. Levings Ill V. RamanathanHarvey F. Lodish Erkki RuoslahtiRichard Losick Ronald H. SchwartzAnthony R. Means Terrence J. Sejnowski
Thomas A. SteitzRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. VermeijBert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteKeith Yamamoto
SCIENCE * VOL. 257 * 31 JULY 1992
SCIENCE
r- 616Conflicts of interest in scienc
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COVERCoral skeleton of the genus Favia. Scleractinian coralssecrete a hard skeleton composed of aragonite(CaCO3), which incorporates strontium along withcalcium in a ratio that depends on sea-surface tempera-ture. Recent findings suggest that for corals of the
genus Porites this dependence may be used to recoverrecords of Pleistocene and Holocene sea-surface tem-peratures with an apparent accuracy of better than O.50C.See page 644. [Photomicrograph: J. W. Beck]
RESEARCH ARTICLEDirected Evolution of an RNA Enzyme F 635A. A. Beaudry and G. F. Joyce
REPORTSTransfer of Biologically Derived 642Nanometer-Scale Patterns to Smooth SubstratesK. Douglas, G. Devaud, N. A. Clark
Sea-Surface Temperature from Coral 644Skeletal Strontium/Calcium Ratios
J. W. Beck, R. L. Edwards, E. Ito, F. W. Taylor,J. Recy, F. Rougerie, P. Joannot, C. Henin
Maintenance of Strong Rotational 647Winds in Venus' Middle Atmosphere byThermal TidesM. Newman and C. Leovy
Elasticity of a-Cristobalite: A Silicon 650Dioxide with a Negative Poisson's RatioA. Yeganeh-Haeri, D. J. Weidner, J. B. Parise
The Location of Bound Lipid in the 652Lipovitellin ComplexP. A. Timmins, B. Poliks, L. Banaszak
Vacuolar Chitinases of Tobacco: A New 655Class of Hydroxyproline-Containing ProteinsL. Sticher, J. Hofsteenge, A. Milani, J.-M. Neuhaus,F. Meins, Jr.
Calcium-Dependent Transmitter SecretionReconstituted in Xenopus Oocytes:Requirement for Synaptophysin
S. Alder, B. Lu, F. Valtorta, P. Greengard,M.-m. Poo
Functional Modulation of GABAAReceptors by cAMP-Dependent ProteinPhosphorylationS. J. Moss, T. G. Smart, C. D. Blackstone,R. L. Huganir
657
661
Neuronal Domains in DevelopingNeocortexR. Yuste, A. Peinado, L. C. Katz
Chloride-Dependent CationConductance Activated During CellularShrinkageH. C. Chan and D. J. Nelson
Mechanistic Aspects of SignalingThrough Ras in NIH 3T3 CellsK. Zhang, A. G. Papageorge, D. R. Lowy
665
669
671
Repression of the Insulin-Like Growth 674Factor II Gene by the Wilms TumorSuppressor WTl
I. A. Drummond, S. L. Madden, P. Rohwer-Nutter,G. I. Bell, V. P. Sukhatme, F. J. Rauscher III
Specialized Role for a MurineClass I-b MHC Molecule in ProkaryoticHost DefensesR. J. Kurlander, S. M. Shawar, M. L. Brown,R. R. Rich
A Protein Kinase Substrate Identified bythe Two-Hybrid SystemX. Yang, E. J. A. Hubbard, M. Carlson
678
680
Participation in Normal Immune ° 682Responses of a Metastasis-Inducing SpliceVariant of CD44R. Arch, K. Wirth, M. Hofmann, H. Ponta,S. Matzku, P. Herrlich, M. Zoller
Cl Indicates accompanying feature
* SCIENCE (ISSN 0036-8075) is published weekly on Friday, except the last week inDecember, by the American Association for the Advancement of Science, 1333 H Street,NW, Washington, DC 20005. Second-class postage (publication No. 484460) paid at Washington,DC, and additional mailing offices. Copyright 1992 by the American Association for the Advance-ment of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic individualmembership and subscription (51 issues): $87 ($47 allocated to subscription). Domestic institutionalsubscription (51 issues): $195. Foreign postage extra: Mexico, Caribbean (surface mail) $50;other countries (air assist delivery) $95. First class, airmail, student and emeritus rates onrequest. Canadian rates with GST available upon request, GST#1254 88122. Change of address:allow 6 weeks, giving old and new addresses and 1 1-digit account number. Postmaster: Sendchange of address to Science, P.O. Box 2033, Marion, OH 43305-2033. Single copy sales: $6.00per issue prepaid includes surface postage; Guide to Biotechnology Products and Instruments, $20.
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SCIENCE * VOL. 257 * 31 JULY 1992
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257 (5070)
(5070), 593-690.257Science
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