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Samuel N Heyman M.D. Jan 2014
LIST OF PUBLICATIONS
ARTICLES
1. Shalev O, Heyman S, Hod G, Adato R. Chronic granulocytic leukemia in pregnancy: A case report and review of the literature. Acta Obstet Gynecol Scand, 59:563-565, 1980.
2. Heyman S, Shalev O, Menczel J. The treatment of Paget's disease. Harefuah 99:438-439, 1980. (Hebrew)
3. Heyman SN, Tobi M, Shalev O. Megaloblastic anemia in vegans. Harefuah 103:148-150, 1982. (Hebrew)
4. Eliakim R, Heyman S, Korenberg A. Autoimmune thrombocytopenic purpura associated with celiac disease and keratoconjunctivitis sicca. Arch Intern Med 142;1037, 1982.
5. Heyman S, Leor R, Halperin Y. Tetanus from machwa wounds. Harefuah 105:63-65, 1983. (Hebrew)
6. Michaeli J, Mogle P, Perlberg S, Heyman S, Caine M. Emphysematous pyelonephritis. J Urology 131:203-208, 1984.
7. Heyman SN, Michaeli J, Brezis M, Gozlan L, Lernau O. Primary hyperparathyroidism presenting as cervical myelopathy. Am J Med Sci 291:112-114, 1986.
8. Brezis M, Heyman SN. Diversity of injuries in renal ischemia. Intern J Artificial Organs 9:7-8, 1986.
9. Heyman SN, Brezis M. Renal medullary hypoxia; Physiological and pathophysiological implications. Harefuah 110:31-33, 1986. (Hebrew)
10. Heyman SN, Brezis M, Stessman J. Water and salt imbalance in the elderly. Harefuah 111:245-248, 1986. (Hebrew)
11. Heyman SN, Stalnikovitch R, Heyman A, Gilon D, Mogle P. Erythromycin-induced dynamic ileus? J Clin Gastroenterol 10:551-554, 1988.
12. Heyman SN, Brezis M, Reubinoff CA, Greenfeld Z, Lechene C, Epstein F, Rosen S. Acute renal failure with selective medullary injury in the rat. J Clin Invest 82:401-412, 1988.
13. Heyman SN, Heyman A, Halperin I. Diabetogenic effect of nifedipine. DICP 23:236-237, 1989.
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14. Heyman SN, Brezis M, Perlberg S, Metzner Y. Bilateral hydronephrosis and erythrocytosis. Harefuah 117:358-360, 1989. (Hebrew)
15. Heyman SN, Brezis M, Greenfeld Z, Rosen S. Protective role of furosemide and saline in radiocontrast-induced acute renal failure in the rat. Am J Kidney Dis 14:377-385, 1989.
16. Heyman SN, Fink R, Benbassat Y. The emergency room as a setting for clinical training. Harefuah 119:141, 1990.(Hebrew)
17. Brezis M, Greenfeld Z, Herman M, Meyer JJ, Heyman SN, Rosen S. Experimental nephrotoxicity of the radiocontrast agents iohexol ioxagglate and iothalamate. An in vivo and in vitro study. Invest Radiol 26:325-331, 1991.
18. Heyman SN, Mevorach D, Ghanem J. Hypertensive crisis from chronic intoxication with nasal decongestant and cough medications. DICP 25:1068-1070, 1991.
19. Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S. Role of nitric oxide in renal medullary oxygen balance. Studies in isolated and intact rat kidneys. J Clin Invest 88:390-395, 1991.
20. Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S. Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 40:632-642, 1991.
21. Heyman SN, Rosen S, Silva P, Spokes K, Egorin MJ, Epstein FH. Protective action of glycine in cisplatin nephrotoxicity. Kidney Int 40:273-279, 1991.
22. Heyman SN, Mammen M. Effect of indomethacin and salt depletion on renal proton MR imaging. An experimental study in the rat. Acta Radiol 32:524-525, 1991.
23. Heyman SN, Clark BA, Kaiser N, Spokes K, Rosen S, Brezis M, Epstein FH. Radiocontrast agents induce endothelin release in vivo and in vitro. J Am Soc Nephrol 3:58-65, 1992.
24. Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Effect of glycine and hypertrophy on renal outer medullary hypoxic injury in ischemia reflow and contrast nephropathy. Am J Kid Dis 19:578-586, 1992.
25. Heyman SN, Clark BA, Kaiser N, Epstein FH, Spokes K, Rosen S, Brezis M. In-vivo and in-vitro studies on the effect of amphotericin B on endothelin release. J Antimicrob Chemotherap 29:69-77, 1992.
26. Heyman SN, Spokes K, Rosen S, Epstein FH. Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor. Kidney Int 42:41-45, 1992.
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27. Stillman IE, Brezis M, Greenfeld Z, Ransil BJ, Heyman SN, Rosen S. Cyclosporine nephropathy: Morphometric analysis of the medullary thick limb. Am J Kid Dis 10:162-167, 1992.
28. Weinstein JM, Heyman SN, Brezis M. Potential deleterious effect of furosemide in radiocontrast nephropathy. Nephron 62:413-415, 1992.
29. Heyman SN, Epstein FH. Glycine and cytopreservation: disappointments and promises. J Lab Clin Med 121:199-200, 1993.
30. Heyman SN, Clark BA, Kaiser N, Cantley L, Spokes K, Rosen S, Brezis M, Epstein FH. Effects of ioversol vs iothalamate on endothelin release and radiocontrast nephropathy. Invest Radiol 28:313-318, 1993.
31. Heyman SN, Eilam O, Dinour D. The osmolar gap as a diagnostic tool in severe alcohol intoxication. Harefuah 124:408-410, 1993. (Hebrew)
32. Heyman SN, Spokes K, Egorin MJ, Epstein FH. Glycine reduces early renal parenchymal uptake of cisplatin. Kidney Int 43:1226-1228, 1993.
33. Heyman SN, Stillman LE, Brezis M, Epstein FH, Spokes K, Rosen S. Chronic amphotericin nephropathy: morphometric, electron microscopic and functional studies. J Am Soc Nephrol 4:69-80, 1993.
34. Brezis M, Heyman SN, Sugar AM. Reduced amphotericin toxicity in albumin vehicle. J Drug Targeting 1:185-9, 1993.
35. Heyman SN, Rosen S, Brezis M. Radiocontrast nephropathy: A paradigm for the synergism between toxic and hypoxic insults in the kidney. Exp Nephrol 2:153-157, 1994.
36. Stillman LE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S. Effects of salt depletion on the kidney: changes in medullary oxygenation and thick ascending limb size. J Am Soc Nephrol 4:1538-1545, 1994.
37. Heyman SN, Rosen S, Epstein FH, Spokes K, Brezis M. Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 45:981-985, 1994.
38. Heyman SN, Agmon Y, Brezis M. Radiologic contrast agents and hypoxic renal medullary injury. Harefuah 127:176-179, 1994. (hebrew)
39. Brezis M, Heyman SN, Epstein F. Determinants of intrarenal oxygenation: 2. Hemodynamic effects. Am J Physiol 267 (Renal Fluid Electrolyte Physiol 36):F1063-F1068, 1994.
40. Mevorach D, Heyman SN. Pain in the marriage. A clinical problem solving. N Engl J Med 332:48-51, 1995.
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41. Heyman SN, Adler S, Stewart B, Aviad I. Benign retropneumoperitoneum induced by emesis. J Clin Gastroenterol 20:88-90, 1995.
42. Heyman SN, Brezis M. Acute renal failure in glomerular bleeding. A puzzling phenomenon. Nephrol Dial Transplant 10:591-593, 1995.
43. Heyman SN, Kaminski N, Brezis M. Dopamine increases medullary blood flow without improving regional hypoxia. Exp Nephrol 3:331-337, 1995.
44. Heyman SN, Babayof I. Emphysematous complications in dentistry, 1960-1993: an illustrative case report and review of the literature. Quintessence Int 26:535-543, 1995.
45. Heyman SN, Fuchs S, Brezis M. The role of medullary ischemia in acute renal failure. New Horizons 3:597-607, 1995.
46. Heyman SN, Rosen S, Fuchs S, Epstein FH, Brezis M. Myoglobinuric acute renal failure in the rat: A role for medullary hypoperfusion, hypoxia and tubular obstruction. J Am Soc Nephrol 7:1066-1074, 1996.
47. Heyman SN, Fuchs S. Yafe R, Beeri R, Elazarian L, Brezis M, Rosen S. Renal microcirculation and tissue damage during acute ureteral obstruction: the effect of saline infusion, indomethacin and radiocontrast. Kidney Int 51:653-63, 1997.
48. Heyman SN, Greenbaum R, Shina A, Rosen S, Brezis M. Myoglobinuric acute renal failure in the rat: a role for acidosis? Exp Nephrol 5:210-16, 1997.
49. Fuchs S, Yaffe R, Beeri R, Rosen S, Heyman SN, Brezis M. Failure of insulin-
like growth factor 1 to improve radiocontrast nephropathy. Exp Nephrol 5:88-94, 1997.
50. Heyman SN, Karmeli F, Rachmilewitz D, Haj Yehia A, Brezis M. Intrarenal nitric oxide monitoring with a clark-type electrode: potential pitfalls. Kidney Int 51:1619-23, 1997.
51. Heyman SN, Karmeli F, Brezis M, Rachmilewitz D. The effect of ketotifen on nitric oxide synthase activity. Br J Pharmacol 120:1545-1551, 1997.
52. Heyman SN, Ginosar Y, Shapiro M, Kluger Y, Marx N, Maayan S. Diarrheal epidemics among Rwandan refugees, 1994: management and outcome in a field hospital. J Clin Gastroenterol 25:595-601, 1997.
53. Heyman SN, Rosen S, Brezis M. The renal medulla: Life at the edge of anoxia. Blood Purif 15:232-242, 1997.
54. Heyman SN, Eldad A, Wiener M. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). Prehosp Disaster Med 13:21-28, 1998.
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55. Heyman SN, Ginosar Y, Niel L, Amir J, Marx N, Shapiro M, Maayan S. Meningococcal meningitis among Rwandan refugees: diagnosis, management and outcome in a field hospital. Int J Infect Dis 2:137-142, 1998.
56. Heyman SN, Goldfarb M, Karmeli F, Shina A, Rachmilewitz D, Brezis M. The effect of radiocontrast on intra-renal nitric oxide (NO) and NO synthase activity. Exp Nephrol 6:557-562, 1998.
57. Heyman SN, Goldfarb M, Darmon D, Brezis M. Tissue oxygenation modifies nitric oxide bioavailability. Microcirculation 6:199-203, 1999.
58. Heyman SN, Reichman J, Brezis M. The pathophysiology of contrast nephropathy: a role for medullary hypoxia. Invest Radiol 34:685-691, 1999.
59. Zlatkin S, Aamar S, Specter G, Simanovsky N, Leibowitz D, Yeshurun D, Heyman SN. Takayasu’s Arteritis identified by computerized tomography: revealing the submerged portion of the iceberg? IMAJ 1:245-249, 1999.
60. Heyman SN, Rosen S, Darmon D, Goldfarb M, Bitz H, Shina A, Brezis M. Endotoxin-induced renal failure: I. a role for altered renal microcirculation. Exp Nephrol 8:266-274, 2000.
61. Heyman SN, Rosen S, Darmon D, Goldfarb M, Bitz H, Shina A, Brezis M. Endotoxin-induced renal failure: II. a role for tubular hypoxic damage. Exp Nephrol 8:275-282, 2000.
62. Bitz H, Darmon D, Goldfarb M, Shina A, Block C, Rosen S, Brezis M, Heyman SN. Transient ureteral obstruction predisposes to ascending pyelonephritis and tubulo-interstitial disease: studies in rats. Urol Res 29:67-73, 2001
63. Reichman J, Shina A, Rosen S, Goldfarb M, Brezis M, Heyman SN. Renal effects of nabumetone: impairment of function in isolated perfused rat kidneys contrasts with preservation of renal function in vivo. Exp Nephrol 9:387-396, 2001
64. Eliakim R, Karmeli F, Cohen P, Heyman SN, Rachmilewitz D. Dual effect of nicotine administration: augmentation of jejunitis and amelioration of colitis induced by iodoacetamide in rats. Int J Colorectal Dis 16:14-21, 2001
65. Goldfarb M, Abassi Z, Rosen S, Shina A, Brezis M, Heyman SN. Chronic heart failure predisposes to hypoxic outer medullary tubular injury: studies in rats. Kidney Int 60:607-613, 2001
66. Rosen S, Heyman SN. Difficulties in understanding human "acute tubular necrosis": limited data and flawed animal models. Kidney Int 60:1220-4, 2001
67. Kassis I, Lak L, Adler J, Rinat C, Shazberg G, Fekede Tewade D, Shoshani E, Miller D, Heyman SN. Medical Relief Operation to Rural Northern Ethiopia: addressing an ongoing disaster. IMAJ 3:772-777, 2001.
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68. Heyman SN, Shina A, Brezis M, Rosen S. Proximal tubular injury attenuates outer medullary hypoxic damage. Studies in the isolated perfused kidney. Exp Nephrol 10:259-266, 2002
69. Heyman SN, Specter G, Aamar S, Rubinger D, Pappo O, Ackerman Z. Systemic Lupus Erythematosus associated with Autoimmune Cholangiopathy. Liver 22:102-106, 2002
70. Heyman SN, Marmor S, Ben-Abraham R, Shani Y, Heled Y, Shapira B, Lifschitz-Mercer B, Amital H. Multi-Organ Failure in a Young Soldier, a clinical-pathological meeting. Harefuah 141:204-209, 2002
71. Heyman SN, Lieberthal W, Rogiers P, Bonventre JV, Animal Models of Acute Tubular Necrosis. Curr Op Crit Care 8:526-534, 2002
72. Heyman SN, Goldfarb M, Shina A, Karmeli F, Rosen S. N-acetylcysteine (NAC) ameliorates renal microcirculation: studies in rats. Kidney Int 63:634-641, 2003
73. Heyman SN, Rosen S. Dye induced nephropathy. Semin Nephrol 23:477-485, 2003
74. Darmon D, Goldfarb M, Shina A, Rosen S, Heyman SN. The effect of poly-(ADP-ribose) polymerase (PARP) inhibition on outer medullary hypoxic damage. Nephron Physiol 95:1-9, 2003
75. Nassar T, Akkawi S, Shina A, Haj-Yehia A, Bdeir K, Tarshis M, Heyman SN, Higazi AAR. The in vitro and in vivo effect of tPA and PAI-1 on blood vessel tone. Blood 103:897-902, 2004
76. Heyman SN, Rosenberger C, Rosen S. Erythropoietin – a potential remedy for renal tubular injury? Kidney Int 65:737-738, 2004
77. Heyman SN, Shina A, Zohair H, Goldfarb M, Rosen S, Higazi AA. The Fibrinolytic System Attenuates Vascular Tone: Effects of Tissue Plasminogen Activator (tPA) and Aminocaproic Acid on Renal Microcirculation. Br J Pharmacol 141:971-978, 2004
78. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P and the ADQI workgroup (including Heyman SN). Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs. The Second International Consensus Conference of the Acute Dialysis Quality Initiative(ADQI) Group. Critical Care 8:R204-R212, 2004
79. Korem M, Ackerman Z, Sciaki-Tamir Y, Gino G, Salameh-Giryes S, Perlberg S, Heyman SN. Post-partum acute kidney failure and hyponatremia - A clinical quiz. IMAJ 6:639-641, 2004
80. Francis BN, Abassi Z, Heyman SN, Winaver J, Hoffman A. Differential regulation of ETA and ETB in the renal tissue of rats with compensated and
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decompensated heart Failure. J Cardiovasc Pharmacol 44 (Suppl 1):S362-S365, 2004
81. Rosenberger C, Heyman SN, Rosen S, Shina A, Gruber G, Goldfarb M, Griethe W, Frei U, Bachmann S, and Eckardt KU. Upregulation of HIF in acute renal failure – evidence for a protective transcriptional response to hypoxia. Kidney Int 67:531-542, 2005
82. Heyman SN, Rosenberger C, Rosen S. Regional alterations in renal hemodynamics and oxygenation: a role in radiocontrast nephropathy. Nephrol Dial Transpl 20 (Suppl 1):i6-i11, 2005
83. Heyman SN, Goldfarb M, Rosenberger C, Shina A, Rosen S. The Effect of nicotine on the renal microcirculation in anesthetized rats: a potential for medullary hypoxic injury? Am J Nephrol 25:226-232, 2005
84. American Society of Nephrology Renal Research Report. J Am Soc Nephrol 16:1886-1903, 2005 (Heyman SN, participant)
85. Benbassat J, Baumal R, Heyman SN, Brezis M. Need for a paradigm shift in teaching basic clinical skills to medical students: the reflective clinical examination. Acad Med 80:1121-1126, 2005
86. Rosenberger C, Rosen S, Heyman S. Current understanding of HIF in renal disease. Kidney and Blood Pressure Research 28:325-340, 2005
87. Damianovich M, Ziv I, Heyman SN, Rosen S, Shina A, Kidron D, Aloya T, Grimberg H, Levin G, Reshef A, Bentolila A, Cohen A, Shirvan A. ApoSense: A Novel Technology for Imaging of Cell Death in Acute Renal Tubular Necrosis Eur J Nucl Med Mol Im 33:281-291, 2006
88. Maril N, Margalit R, Rosen S, Heyman SN, Degani H. Detection of Evolving Acute Tubular Necrosis with Renal 23Sodium MRI: Studies in Rats. Kidney Int 69:765-8, 2006
89. Goldfarb M, Rosenberger C, Abassi Z, Shina A, Zilbersat F, Eckhardt KU, Rosen S, Heyman SN. Acute-on-chronic renal failure in the rat: Functional compensation and hypoxia tolerance. Am J Nephrol 26:22-33, 2006
90. Rosenberger C, Shina A, Rosen S, Goldfarb M, Eckardt K, Heyman SN. Hypoxia inducible factors and tubular cell survival in isolated perfused kidneys. Kidney Int 70:60-70, 2006
91. Goldfarb M, Rosenberger C, Shina A, Rosen S, Heyman SN. A Role for Erythropoietin in the Attenuation of Contrast Medium-Induced Acute Renal Failure in Rats? Renal Failure 28:345-350, 2006
92. Elinav E, Rubinger D, Hiller N, Pizov G, Nadir E, Shapira Y, Heyman SN. Renal vein thrombosis and membranous glomerulopathy in a patient homozygote for factor V Leiden mutation: A mere coincidence? J Thromb Haemost 95:740-743, 2006
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93. Rosenberger C, Rosen S, Heyman SN. Renal Parenchymal Oxygenation and Hypoxia Adaptation in Acute Kidney Injury. Clin Exp Pharmacol Physiol 33:980-988, 2006
94. Netz Y, Argov E, Burstin A, Brown R, Heyman SN, Dunsky A, Alexander N. Using a standing support device physical activity program to improve function in disabled wheelchair-bound nursing home residents: a pilot study. Disabil Rehabil Assist Technol 2:43-9, 2007
95. Heyman SN, Reches A, Safadi R, Cohen R. Introduction of a Brief Problem–Based–Learning (PBL) Experience in Traditional Medical School Curriculum. Harefuah 146: 435-8, 2007
96. Rosenberger C, Pratschke J, Rudolph B, Rosen S, Heyman SN, Babel N, Schindler R, Eckhardt KW, Frei U, Reinke P. Immunohistochemical Detection of Hypoxia-Inducible Factor-1alpha in Human Renal Allograft Biopsies. J Am Soc Nephrol 18:343-51, 2007
97. Nassar H, Lavi E, Akkawi S, Heyman SN, Raghunath PN, Tomaszewski J, Higazi AAR. α-defensin: Link between inflammation and atherosclerosis. Atherosclerosis 194: 452-7, 2007
98. Rosenberger C, Khamaisi M, Abassi Z, Weksler-Zengen S, Goldfarb M, Shilo V, Shina A, Zilbertrest F, Eckhardt KW, Rosen S, Heyman SN. Adaptation to hypoxia in the diabetic rat kidney. Kidney Int 73:34-42, 2008
99. Heyman SN, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation and the pathogenesis of radiocontrast nephropathy. Clinical J Am Soc Nephrol 3:288-96, 2008
100. Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt KU, Schrader T, Rosen S, Heyman SN. Evidence for Sustained Renal Hypoxia and Transient Hypoxia Adaptation in Experimental Rhabdomyolysis-Induced Acute Kidney Injury. Nephrol Dial Transpl 23:1135-43, 2008
101. Khamaisi M, Raz I, Shilo V, Shina A, Rosenberger C, Dahan R, Abassi Z, Meidan R, Lecht S, Heyman SN. Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney. Kidney Int 74:91-100, 2008
102. Rosenberg C, Goldfarb M, Khamaisi M, Shina A, Shilo V, Rosen S, Heyman SN. Acute kidney injury in the diabetic rat: studies in the isolated perfused and intact kidney. Am J Nephrol 28:831-9, 2008
103. Rosenberger C, Rosen S, Shina A, Frei U, Eckardt KU, Flippin LA, Arend M, Klaus SJ, Heyman SN. Activation of hypoxia inducible factors (HIF) ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial transplant 23: 3472–3478, 2008
104. Heyman SN, Khamaisi M, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol 28:998-1006, 2008
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105. Khamaisi M, Dahan R, Hamed S, Abassi Z, Heyman SN, Raz I. Role of Protein Kinase C in the Expression of Endothelin Converting Enzyme-1 in Endothelial Cells. Endocrinology 150:1440-1449, 2009
106. Heyman SN, Rosen S, Rosenberger C. Animal models of renal dysfunction: acute kidney injury. Expert Opinion on Drug Discovery 4: 629-641, 2009
107. Kahn A, Koslowsky B, Nir-Paz R, Temper V, Hiller N, Karlinsky A, Gur I, Hidalgo-Grass C, Heyman SN, Moses AE, Block C. Imported melioidosis in Israel: recognition and consequences. Emerg Infect Dis 15:1809-11, 2009
108. Ben-Chetrit E, Peleg H, Aamer S, Heyman SN. The spectrum of MEFV associated diseases – Is it familial Mediterranean fever (FMF) only? Rheumatology (Oxford), 48:1445-9, 2009
109. Karram T, Khamaisi M, Bishara B, Ramadan R, Nitecki S, Ben-Izhak O, Meretyk S, Winaver J, Heyman SN, Hoffman A, Abassi Z. Expression of endothelin receptors in human kidney: Possible source of urinary ETA and ETB. Kidney & Blood Pressure Research 32:293-303, 2009
110. Khamaisi M, Heyman SN. The role of hypoxia and hypoxia adaptive response in the progression of chronic kidney disease. Harefuah, 148:721-6, 2009 (Hebrew)
111. Heyman SN, Rosenberger C, Rosen S. Experimental ischemia-reperfusion - biases and myths: the proximal vs. distal hypoxic tubular injury debate revisited. Kidney Int 77:9-16, 2010
112. Paliege A, Rosenberger C, Bondke A, Sciesielski L, Shina A, Heyman SN, Flippin LA, Arend M, Klaus SJ, Bachmann S. Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Kidney Int 77:312-8, 2010
113. Heyman SN, Rosen S, Khamaisi M, Idee JM, Rosenberger C. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol 45:188-195, 2010
114. Khamaisi M, Heyman SN. Bicarbonate for the prevention of contrast nephropathy in high risk patients with chronic renal failure and/or diabetes. Harefuah Update: Diabetes 1:8-10, 2010 (Hebrew)
115. Heyman SN, Ben Yehuda A, Brezis M. Additional remedies for the failing departments of internal medicine. Harefuah 149:756-7, 2010 (Hebrew)
116. Heyman SN, Khamaisi M, Rosen S, Rosenberger C. In vivo models of acute kidney injury. Drug Discovery Today: Disease Models 7:51-56, 2010
117. Abu Fanne R, Nassar T, Mazuz A, Waked O, Akkawi S, Hijazi N, Heyman SN, Goelman G, Higazi AAR. Neuroprotection by glucagon: Role of gluconeogenesis. J Neurosurgery 114:85-91, 2011
118. Sagiv I, Koslowsky B, Korem M, Hiller N, Heyman SN. Scattered striated persistent nephrogram in sepsis. Nephrol Dial Transpl 26:2053-2055, 2011
119. Heyman SN, Rosen S, Rosenberger C. Hypoxia inducible factors and the prevention of acute organ injury. Crit Care 15:209-216, 2011
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120. Heyman SN, Rosem S, Rosenberger C. Sepsis-induced acute kidney injury: A role for oxidative stress. Contrib Nephrol 174:138-148, 2011
121. Gershinsky Y, Heyman SN. Unilateral purpuric rash in a patient with acute renal failure. IMAJ 13: 515, 2011
122. Abu Fanne R , Nassar T, Heyman SN, Hijazi N, Higazi AA. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol (Regul Integr Comp Physiol) 301:R668-673, 2011
123. Abu-Saleh N, Ovcharenko E, Awad H, Goltsman I, Khamaisi M, Heyman S, Hoffman A, Wianver J, Abassi Z. Involvement of the endothelin and nitric oxide system in the pathogenesis of renal ischemic damage in an experimental diabetic model. Life Sci 91:669-75, 2012
124. Heyman SN, Evans R, Rosen S, Rosenberger C. Cellular adaptive changes in AKI: mitigating renal hypoxic injury. Nephrol Dial Transpl 27: 1721–1728, 2012
125. Milman Z, Axelrod J, Heyman SN, Corchia N, Tsarfati G, Abramovitch R. Hemodynamic response magnetic resonance imaging: application for renal hemodynamic characterization. Nephrol Dial Transpl 28:1150-6, 2013
126. Nangaku M, Rosenberger C, Heyman SN, Eckardt KU. HIF regulation in kidney disease Clin Exp Pharmacol Physiol 40:148-57, 2013
127. Milgrom Y, Sabag Z, Zlotogorski A, Heyman SN. Erythema ab-igne of shins: a kerosene stove-induced prototype in diabetics. J Postgrad Med 59:56-7, 2013
128. Sohotnik R, Nativ O, Abbasi A, Awad H, Frajewicki V, Bishara B, Sokhotnik I, Armaly Z, Heyman S, Nativ O, Abassi Z. Phosphodiesterase 5 inhibition attenuates early renal ischemia/reperfusion-induced acute kidney injury: assessment by measurement of urinary NGAL and KIM-1. Am J Physiol Renal Physiol 304:F1099-104, 2013
129. Nechemia-Arbeli Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Schriki A, Klaus S, Rosen S, Axelrod J, Rose-John S, Galun E, Heyman SN. In vivo evidence suggesting reciprocal renal HIF-1 up-regulation and STAT3 activation in response to hypoxic and non-hypoxic stimuli Clin Exp Pharmacol Physiol 40:262-72, 2013
130. Heyman SN, Rosenberger C, Rosen S, Khamaisi M. Why is diabetes mellitus a risk factor for contrast nephropathy? Biomed Res Int 2013:123589, 2013
131. Abu-Saleh N, Awad H, Khamaisi M, Armali Z, Karram T, Heyman SN, Kaballa A, Ichimura T, Holman J, Abassi Z. Nephroprotective effects of TVP1022, a non-MAO inhibitor S-Isomer of rasagiline, in experimental model of diabetic renal ischemic injury. Am J Physiology, Renal Physiology 306(1):F24-33, 2014
132. Lossos A, Teltsh O, Milman T, Meiner V, Rozen R, Leclerc R, Rosenblatt DS, Watkins D, Shaag A, Korman S, Heyman SN, Gal A, Newman JP, Steiner-Birmanns B; Abramsky O, Kohn Y. Severe MTHFR deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia. JAMA Neurology (in press)
133. Suhail A, Peleg H, Leibowitz D, Chajek-Shaul T, Hiller N, Heyman SN. Efficacy of Adalimumab Therapy for Life-Threatening Pulmonary Vasculitis in Behçet's Disease. Rhematol Int 34:867-860, 2014
134. Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment of renal morphology and hemodynamics in acute and chronic kidney disease in mice by unenhanced MRI techniques. Am J Nephrol 39: 268-78, 2014
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135. Peleg H, Koslowski B, Hiller N, Heyman SN. Radiologic features of acne fulminans. IMAJ (in press)
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LETTERS AND CORRESPONDENCE
1. Yagil Y, Heyman S. Makwa (non sterile skin cauterization) as a cause of tetanus. Lancet, 1 May; 1207, 1982.
2. Heyman SN, Heyman A. Rare side effects of oral anticoagulants. Harefuah, 112;371, 1987. (Hebrew)
3. Heyman SN, Greenfeld Z, Behar M, Mogle P, Brezis M. Spinal myoclonus induced by contrast material: An alternative explanation. AJNR 10:653, 1989.
4. Heyman SN. Verapamil intoxication and hyperglycemia. J Emerg Med 7:407, 1989.
5. Amitai Y, Heyman S. Additional causes of priapism. Ann Emerg Med 19:1357-8, 1990.
6. Eilam O, Heyman SN. Wenckebach type atrioventricular block in severe alcohol intoxication. Ann Emerg Med 20:1170, 1991.
7. Heyman SN. The usage of osmolar gap. Harefuah 125:126-127, 1993. (Hebrew) 8. Heyman SN, Horovitz J, Nehama H, Sofer S, Orbach J, Amir Y, Adar A. Sudden death
during fluid resuscitation: a lesson from Rwanda. Lancet 344:1509-1510, 1994.
9. Shpilberg O, Pikarsky A, Heimann S, Epstein Y, Burstein R. Coma in mild hypothermia. Aviat Space Environ Med 65:878, 1994.
10. Heyman SN, Brezis M. Asymptomatic group-B streptococcal pyelonephritis: an unusual cause of acute renal failure. Nephron 75:243-244, 1997.
11. Rosen S, Bits H, Darmon D, Brezis M, Heyman S. Kitamura et al.: Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat. Kidney Int 54:301-302, 1998.
12. Heyman SN. Furosemide drip in diuretic-resistant congestive heart failure. Harefuah 139:163, 2000. (Hebrew)
13. Heyman SN. Dopamine for acute renal failure: update. Harefuah 141:492-3, 2002 (Hebrew)
14. Elinav E, Ackerman Z, Goterer A, Heyman SN. Acetazolamide-induced severe metabolic acidosis in a patient with diabetic type IV renal tubular acidosis. Ann Emerg Med 40:258-9, 2002
15. Gatt ME, Heyman SN. Treatment of tobacco use and dependence. N Engl J Med 347:294, 2002
16. Rosen S, Heyman SN. Concerns about KIM-1 as a Urinary Biomarker for ATN. Kidney Int 63:1955, 2003
17. Ackerman Z, Salemah S, Korem M, Heyman SN. Cyclic psychosis associated with the menstrual cycle. Possibly attacks of neuroporphyria. Harefuah 143:157, 2004
18. Heyman SN, Babayof I. Emphysematous complications in dentistry. IMAJ 7:278, 2005.
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19. Heyman, SN. New usage for an old drug: acetylcysteine for contrast-induced nephropathy. 145:239, 2006 (Hebrew)
20. Rosenberger C, Rosen S, Heyman SN. Normotensive ischemic acute renal failure. N Engl J Med 357:2204-5, 2007
21. Heyman SN. Myocardial ischemic preconditioning. Harefuah 147:655-6, 2008 (Hebrew)
22. Heyman SN, Darmon D, Ackerman Z, Rosenberger C, Rosen S. Bile acid nephropathy. Kidney Int 85:479, 2014
PROCEEDINGS, INTERNET PUBLICATIONS AND MISCELLANIOUS
1. Brezis M, Heyman SN, Greenfeld Z, Rosen S. Acute renal failure with thick ascending limb necrosis from combined kidney insults in the rat. Proceedings of the Xth International Congress of Nephrology. Nephrology, Davison AM (ed), Baillere Tindall, London pp 945-954, 1988.
2. Heyman SN. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). F.I.P., Military and Emergency Pharmacy Section. pp 1-8, Ittigen, Switzerland, 1997.
3. Heyman SN. Airborne Field Hospital in Disaster Settings: The Israeli Model. Aruchim (Readiness), Bulletin of the Israeli Ministry of Health, Emergency Division 5:9-11, 2000 (Hebrew).
4. Bonventre JV, Heyman SN, Lieberthal W, Rogiers P. Animal models of acute tubular necrosis, in: The ADQI II report, ADQI website (www.adqi.net), June 2003
5. Heyman SN. Regional alterations in renal hemodynamics and oxygenation: a role in radiocontrast nephropathy. In: Contrast Media Induced Nephropathy (CIN) Booklet by Schering, Bracco and Guebert, the European Renal Association / ETDA meeting, Lisbon, 2004
6. Heyman SN. Primary prevention of dye-induced nephropathy. In: ICU Nephrology, ARF and the Management of Poisoning. Postgraduate Education Course of the American Society of Nephrology. pp 103-119, Oct 2004
7. Heyman SN. Primary prevention of dye-induced nephropathy. Hypertension, Dialysis & Clinical nephrology. HDCN website (http://www.hdcm.com/symp/04asn , login+pass=Lex), 2005
8. Block C, Cahn A, Koslowsky B, Nir-Paz R, Temper V, Karlinsky A, Gur I, Heyman SN, Mozes A. Melioidosis - Israel ex Thailand,
http://www.promedmail.org/pls/otn/f?p=2400:1001:1229382893353517::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,73614, 19 Aug, 20089. Heyman SN. Radiocontrast nephropathy. In G-Med, 30 May 2013.
http://www.g-med.co.il/web/heb/DiseaseArticle.aspx?diseaseID=80710. Heyman SN. Rhabdomyolysis. In G-Med 6 Feb 2014 http://www.g-med.co.il/web/heb/DiseaseArticle.aspx?diseaseID=901&CatID=0&Ltr=%D7%AA%D7%99%D7%A1%D7%9E%D7%95%D7%A0%D7%AA%20%D7%94%D7%9E%D7%A2%D7%99%D7%9B%D7%94%20|%20Crush%20syndrome,%20Rhabdomyolysis
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F1000 EVALUATIONS
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged
mice. Dear JW, Kobayashi H, Jo SK, Holly MK, Hu X, Yuen PS, Brechbiel MW, Star RA. Kidney Int. 2005
Jun; 67(6):2159-67 http://f1000.com/prime/8044
Urinary excretion of liver-type fatty acid-binding protein in contrast medium-induced nephropathy. Nakamura
T, Sugaya T, Node K, Ueda Y, Koide H. Am J Kidney Dis. 2006 Mar; 47(3):439-44
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Nephrotoxic effects in high-risk patients undergoing angiography. Aspelin P, Aubry P, Berg KJ. N Engl J Med.
2003 Feb6; 348(6):491-9 http://f1000.com/prime/12367#eval471171
N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. Marenzi G, Assanelli E, Marana I,
Lauri G ... Fabbiocchi F, Montorsi P, Veglia F, Bartorelli AL. Marenzi G, Assanelli E, Marana I, Lauri G,
Campodonico J, Grazi M, De Metrio M, Galli S, Fabbiocchi F, Montorsi P, Veglia F, Bartorelli AL. N Engl J
Med. 2006 Jun 29; 354(26):2773-82 http://f1000.com/prime/14521#eval472202
NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Hirsch R, Dent C, Pfriem
H, Allen J ... Dastrala S, Bennett M, Mitsnefes M, Devarajan P. Hirsch R, Dent C, Pfriem H, Allen J, Beekman
RH, Ma Q, Dastrala S, Bennett M, Mitsnefes M, Devarajan P. Pediatr Nephrol. 2007 Dec; 22(12):2089-95
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Ultra-low contrast volumes reduce rates of contrast-induced nephropathy in patients with chronic kidney disease
undergoing coronary angiography. Kane GC, Doyle BJ, Lerman A, Barsness GW, Best PJ, Rihal CS. J Am Coll
Cardiol. 2008 Jan 1; 51(1):89- http://f1000.com/prime/1104743
Asialoerythropoietin prevents contrast-induced nephropathy. Yokomaku Y, Sugimoto T, Kume S, Araki S ...
Haneda M, Koya D, Uzu T, Kashiwagi A. Yokomaku Y, Sugimoto T, Kume S, Araki S, Isshiki K, Chin-
Kanasaki M, Sakaguchi M, Nitta N, Haneda M, Koya D, Uzu T, Kashiwagi A. J Am Soc Nephrol. 2008 Feb;
19(2):321-8 http://f1000.com/prime/1103775#eval559895
Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Koyner
JL, Bennett MR, Worcester EM, Ma Q ... Konczal DJ, Trevino S, Devarajan P, Murray PT. Koyner JL, Bennett
MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S,
Devarajan P, Murray PT. Kidney Int. 2008 Oct; 74(8):1059-69 http://f1000.com/prime/1120181#eval584293
Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Doi K,
Leelahavanichkul A, Hu X, Sidransky KL ... Eisner C, Schnermann J, Yuen PS, Star RA. Doi K,
Leelahavanichkul A, Hu X, Sidransky KL, Zhou H, Qin Y, Eisner C, Schnermann J, Yuen PS, Star RA. Kidney
Int. 2008 Oct; 74(8):1017-25 http://f1000.com/prime/1129827
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Acute kidney injury after hepatic ischemia and reperfusion injury in mice. Lee HT, Park SW, Kim M, D'Agati
VD. Lab Invest. 2009 Feb; 89(2):196-208 http://f1000.com/prime/1161509
Iodixanol, constriction of medullary descending vasa recta, and risk for contrast medium-induced nephropathy.
Sendeski M, Patzak A, Pallone TL, Cao C, Persson AE, Persson PB. Radiology. 2009 Jun; 251(3):697-704
http://f1000.com/prime/1163714
Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI. Atthe BK, Babsky AM, Hopewell
PN, Phillips CL, Molitoris BA, Bansal N. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1288-98
http://f1000.com/prime/1282020
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in
obstructive nephropathy. Pang M, Ma L, Gong R, Tolbert E ... Chin YE, Yan H, Dworkin LD, Zhuang S. Pang
M, Ma L, Gong R, Tolbert E, Mao H, Ponnusamy M, Chin YE, Yan H, Dworkin LD, Zhuang S. Kidney Int.
2010 Aug; 78(3):257-68 http://f1000.com/prime/4831960
Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for
preeclampsia and intrauterine growth restriction. Tal R, Shaish A, Barshack I, Polak-Charcon S ... Volkov A,
Feldman B, Avivi C, Harats D. Tal R, Shaish A, Barshack I, Polak-Charcon S, Afek A, Volkov A, Feldman B,
Avivi C, Harats D. Am J Pathol. 2010 Dec; 177(6):2950-62 http://f1000.com/prime/5879960
The Ngal reporter mouse detects the response of the kidney to injury in real time. Paragas N, Qiu A, Zhang Q,
Samstein B ... Landry DW, D'Agati V, Lin CS, Barasch J. Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX,
Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ,
Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. Nat Med. 2011 Feb; 17(2):216-22
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Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. Szeto HH, Liu S,
Soong Y, Wu D ... Zhao Z, Ganger M, Tow CY, Seshan SV. Szeto HH, Liu S, Soong Y, Wu D, Darrah SF,
Cheng FY, Zhao Z, Ganger M, Tow CY, Seshan SV. J Am Soc Nephrol. 2011 Jun; 22(6):1041-52
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Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-
risk patients for contrast-induced acute kidney injury. Briguori C, Visconti G, Focaccio A, Airoldi F ... Golia B,
Ricciardelli B, Condorelli G, REMEDIAL II Investigators. Briguori C, Visconti G, Focaccio A, Airoldi F,
Valgimigli M, Sangiorgi GM, Golia B, Ricciardelli B, Condorelli G, REMEDIAL II Investigators. Circulation.
2011 Sep 13; 124(11):1260-9 http://f1000.com/prime/13328995
PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice.Tran M, Tam D,
Bardia A, Bhasin M ... Karumanchi SA, Stillman IE, Arany Z, Parikh SM. Tran M, Tam D, Bardia A, Bhasin
M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D,
Karumanchi SA, Stillman IE, Arany Z, Parikh SM. J Clin Invest. 2011 Oct 3; 121(10):4003-14
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Aberrant tubuloglomerular feedback and HIF-1α confer resistance to ischemia after subtotal nephrectomy. Singh
P, Blantz RC, Rosenberger C, Gabbai FB, Schoeb TR, Thomson SC. J Am Soc Nephrol. 2012 Mar; 23(3):483-93
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Ischemic Preconditioning for Prevention of Contrast-Medium-Induced Nephropathy: Randomized Pilot RenPro-
Trial (Renal Protection Trial). Er F, Nia AM, Dopp H, Hellmich M ... Benzing T, Erdmann E, Burst V,
Gassanov N. Er F, Nia AM, Dopp H, Hellmich M, Dahlem KM, Caglayan E, Kubacki T, Benzing T, Erdmann
E, Burst V, Gassanov N. Circulation. 2012 Jun 26 http://f1000.com/prime/717948025#eval793461511
Risk of acute kidney injury in patients who undergo coronary angiography and cardiac surgery in close
succession. Ko B, Garcia S, Mithani S, Tholakanahalli V, Adabag S. Eur Heart J. 2012 Aug; 33(16):2065-70
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A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy.
Kodama A, Watanabe H, Tanaka R, Tanaka H ... Ishima Y, Fukagawa M, Otagiri M, Maruyama T. Kodama A,
Watanabe H, Tanaka R, Tanaka H, Chuang VT, Miyamoto Y, Wu Q, Endo M, Hamasaki K, Ishima Y,
Fukagawa M, Otagiri M, Maruyama T. Kidney Int. 2013 Mar; 83(3):446-54 http://f1000.com/prime/717983228
Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction.
van Slambrouck CM, Salem F, Meehan SM, Chang A. Kidney Int. 2013 Jul; 84(1):192-7,
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Tubular von Hippel-Lindau Knockout Protects against Rhabdomyolysis-Induced AKI. M Fähling, S Mathia, A
Paliege, R Koesters, R Mrowka, H Peters, PB Persson, HH Neumayer, S Bachmann and C Rosenberger. J Am
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Increased risk of acute kidney injury associated with higher infusion rate of mannitol in patients with
intracranial hemorrhage. Kim MY, Park JH, Kang NR, Jang HR ... Kim DJ, Hong SC, Kim JS, Oh HY. J
Neurosurg. 2014 http://f1000.com/prime/718262770
CHAPTERS IN BOOKS
1. Heyman SN, Weinstein JM, Rosen S, Brezis M. Current concepts on the pathophysiology of radiocontrast nephrotoxicity. In: "Seminaires d' Uro-Nephrologie". Pitie-Salpetriere, Masson pub., Paris, pp 188-192, 1990.
2. Heyman SN, Greenfeld Z, Brezis M. Succeptability of the kidney to hypoxia. In:
"Update in Intensive Care and Emergency Medicine (14)", Update 1991. JL Vincent (editor), Springer Verlag, Berlin, pp 435-443, 1991.
3. Heyman SN, Rosen S, Brezis M. The renal medulla: Life at the edge of anoxia. In
"Circulation in Native and Artificial Kidneys". C Ronco, A Artigas, R Bellomo (Eds), S Karger AG, Basel, pp 16-26, 1997.
4. Heyman SN, Brezis M, Rosen S. The isolated perfused rat kidney model in experimental renal injury. In "Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals", Bennett WM, DeBroe ME, Porter GA, Verpooten GA (Eds), Kluwer Academic Publishers, Dordrecht, pp 77-82, 1998.
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5. Heyman SN. Furosemide and oxygen sparing. In “Critical Care Focus (1) Renal Failure”, Galley HF (Ed), Intensive Care Society, BMJ Books, London, pp 45-59, 1999.
6. Heyman SN, Brezis M. The Kidney. In “Pulmonary and peripheral gas exchange in health and disease”, Roca J, Rodriguez-Roisin R, Wagner P (Eds), Lung Biology in Health and Disease Vol 148, Marcel Dekker Inc., New York, pp 447-467, 2000.
7. Heyman SN, Brezis M, Cronin RE. Radiocontrast Media-Induced Acute Renal Failure. In "Diseases of the Kidney and Urinary Tract", Schrier R (Ed.), 8 th edition, Lippincott, Williams and Wilkins pp 1099-1120, 2006
8. Heyman SN. Iron Poisoning. In "Israeli Encyclopedia of Medicine", Y shoenfeld (Ed.) Israeli Medical Association and Yediot Pub, pp 1852-3, 2007
9. Rosenberger C, Rosen S, Paliege A, Heyman SN. Pimonidazole Adduct Immunohistochemistry in the Rat Kidney: Detection of Tissue Hypoxia. In "Methods of Molecular Biology" Vol 466: Kidney Research. Hewitson TD, Becker GJ (Ed), Springer / Humama Press, Totowa, NJ, pp161-174, 2009
10. Heyman SN, Rosen S, Rosenberger C. Critical assessment of experimental models of acute renal failure. In "Critical Care Nephrology", Ronco C, Bellomo R & Kellum J (Eds), 2nd Ed, Saunders/Elsevier, pp 237-250, 2009
11. Heyman SN, Rosen S, Khamaisi M, Idee JM, Rosenberger C. Hypoxia, Oxidative Stress and the Pathophysiology of Contrast-Media-Induced Nephropathy. In: "Oxidative Stress in Basic Research and Clinical Practice: Studies on Renal Disorders" Miyata T, Eckardt KW, Nangaku M (Eds), Humana Press/Springer Science, pp 229-256, 2011
12. Heyman SN, Rosenberger C, Rosen S. Acute Kidney Injury: Lessons from Experimental Models. In: "Experimental Models for Renal Diseases: Pathogenesis and Diagnosis". Herrara GA (Ed), Karger Co., Basel. Contrib Nephrol, Vol. 169, pp 286-296, 2011
13. Heyman SN, Rosen S, Rosenberger C. Hypoxia inducible factors and the prevention of acute organ injury. In: Annual Update in Intensive Care and Emergency Medicine 2011, Vincent JL (Ed), Springer Verlag, Berlin Heidelberg, pp 37-47, 2011
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ABSTRACTS
1. Heyman SN, Reubinoff CA, Brezis M, Epstein FH, Rosen S. Acute renal failure (ARF) from radiocontrast; Selective injury to medullary thick ascending limbs (mTALs). A possible pathogenic mechanism. American Federation for Clinical Recearch. Annual Meeting Washington DC, May, 1986.
2. Rosen S, Brezis M, Heyman SN, Greenfeld Z, Epstein FH. Acute renal failure with selective medullary injury from combined insults in rats; Role of medullary hypoxia. Clin Res 35;637A, 1987.
3. Brezis M, Heyman SN, Greenfeld Z, Epstein FH, Rosen S. Selective hypoxic injury to medullary thick assending limb in vivo. International Congress of Nephrology, London, 1987.
4. Rosen S, Heyman SN, Reubinoff CA, Greenfeld Z, Lechene C, Epstein FH, Brezis M. Radiocontrast Nephropathy. United States and Canadian Academy of Pathology, Annual Meeting, 1988.
5. Heyman SN, Brezis M, Greenfeld Z, Rosen S. Protective role of furosemide and saline in radiocontrast induced acute renal failure. Clin Res 36:520A, 1988.
6. Brezis M, Heyman SN, Spokes K, Epstein FH, Rosen S. Role of nitric oxide in medullary oxygen balance. J Am Soc Nephrol 1:438, 1990.
7. Epstein FH, Heyman SN, Spokes K, Rosen S. Mechanism of glycine protection in hypoxic injury: Analogies with glycine receptor. J Am Soc Nephrol 1:595, 1990.
8. Clark BA, Heyman SN, Spokes K, West C, Epstein FH. Rise in plasma endothelin produced by radiocontrast agents. J Am Soc Nephrol 1:412, 1990.
9. Heyman SN, Spokes K, Epstein FH, Brezis M, Silva P, Rosen S. Early functional and morphological changes in radiocontrast nephropathy. J Am Soc Nephrol 1:596, 1990.
10. Stillman IE, Brezis M, Greenfeld Z, Heyman SN, Rosen S. The effect of cyclosporine A on the medullary thick ascending limb. J Am Soc Nephrol 1:620, 1990.
11. Stillman IE, Brezis M, Greenfeld Z, Heyman SN, Rosen S. Cyclosporine (CsA) toxicity: morphometric analysis of the medullary thick ascending limb (mTAL). United States and Canadian Academy of Pathology, Annual meeting, 1991.
12. Heyman SN, Brezis M, Epstein FH, Spokes K, Stillman I, Rosen S. Chronic amphotericin nephropathy: selective inner stripe and medullary ray injury. Clin Res 39:248A, 1991.
13. Heyman SN, Clark BA, Kaiser N, Rosen S, Brezis M, Spokes K, Epstein FH. Radiocontrast agents induce endothelin release from cultured endothelial cells. Clin Res 32:309A, 1991.
14. Brezis M, Heyman SN, Fuhro R, Epstein FH. Determinants of intrarenal oxygenation gradients. Clin Res 32:389A, 1991.
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15. Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Glycine increases medullary thick ascending limb (mTAL) damage from radiocontrast and hypoxic insults in rats. A role for medullary oxygen insufficiency ? J Am Soc Nephrol 2:647, 1991.
16. Heyman SN, Clark BA, Cantley L, Brezis M, Rosen S, Kaiser N, Spokes K, Epstein FH. Low toxicity of the radiocontrast agent ioversol: relationship to reduced stimulation of endothelin release? J Am Soc Nephrol 2:664, 1991.
17. Brezis M, Heyman SN, Fuhro R, Epstein FH, Rosen S. Intrarenal vasoconstriction in myoglobin nephrotoxicity. J Am Soc Nephrol 2:644, 1991.
18. Cantley LG, Heyman SN, Epstein FH. Radiocontrast agents induce endothelin-1 mRNA in bovine endothelial cells. J Am Soc Nephrol 2:660, 1991.
19. Rosen S, Brezis M, Epstein FH, Spokes K, Heyman SN. Medullary thick ascending limb (mTAL) injury in the ischemia-reflow model. J Am Soc Nephrol 2:654, 1991.
20. Rosen S, Heyman SN, Epstein FH, Spokes K, Stillman I, Brezis M. Regional vulnerability of the kidney to hypoxia. In "Newer Aspects of Renal Cell Injury, A Forefronts in Nephrology Symposium (Int Soc Nephrol), 1991.
21. Stillman LE, Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Adaptation of the renal medulla to salt deficiency: Alterations in mTAL size and medullary pO2. J Am Soc Nephrol 3:820, 1992.
22. Stillman LE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S. Effects of salt depletion on the kidney: changes in medullary oxygenation and medullary thick ascending limb size. XIIth International Congress of Nephrology, Jerusalem, 554, 1993.
23. Heyman SN, Kamimski N, Brezis M. Effects of dopamine (D) on renal microcirculation and oxygenation. J Am Soc Nephrol 5:604, 1994.
24. Heyman SN, Karmeli F, Rachmilewitz D, Brezis M. Ketotifen induces nitric oxide synthase (NOS) and renal vasodilation. J Am Soc Nephrol 5:580, 1994.
25. Heyman SN, Fuchs S, Yafe R, Beeri R, Shina A, Brezis M, Rosen S. Impaired renal medullary microcirculation and tissue damage during acute ureteral obstruction: clinical implications? J Am Soc Nephrol 6:980, 1995.
26. Fuchs S, Jaffe R, Beeri R, Heyman SN, Shina A, Rosen S, Brezis M. Failure of insulin-like growth factor 1 (IGF-1) to improve radiocontrast nephropathy. J Am Soc Nephrol 6:997, 1995.
27. Heyman SN, Brezis M. Pathophysiology of radiocontrast nephropathy. J Radiologie 76:727, 1995.
28. Heyman SN, Greenbaum R, Shina A, Rosen S, Brezis M. Myoglobinuric acute renal failure in the rat: a role for acidosis? Annual meeting of the Israeli Association for Emergency Medicine, 1996.
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29. Heyman SN, Fuchs S, Jafe R, Beeri R, Rosen S, Brezis M. Deleterious effects of indomethacin, forced hydration and radiocontrast on renal microcirculation and morphology during acute ureteral obstruction in the rat:implications for the treatment of renal colic? Annual meeting of the Israeli Association for Emergency Medicine, 1996.
30. Babayof I, Heyman SN. Emphysematous complications in dentistry, 1960-1993. Annual meeting of the Israeli Association for Emergency Medicine, 1996.
31. Heyman SN. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). Pharmacy Word Congress, Jerusalem, 1996.
32. Heyman SN, Brezis M. The outer medulla: Life at the edge of anoxia. Third Annual Symposium on Applied Physiology of the Peripheral Circulation, Barcelona, 1996.
33. Heyman SN, Haj Ichia A, Rachmilewitz D, Brezis M. Intrarenal nitric oxide monitoring with a clark-type electrode: potential pitfalls. J Am Soc Nephrol 9:1563, 1996.
34. Heyman SN, Rosen S, Brezis M. Effects of endotoxin upon intrarenal microcirculation. J Am Soc Neprol 9:1862, 1996.
35. Heyman SN, Darmon D, Goldfarb M, Bits H, Shina A, Brezis M, Rosen S. Endotoxin (E) induces medullary hypoxic damage: studies in-vivo and in isolated perfused kidneys. J Am Soc Nephrol 8:602A, 1997.
36. Heyman SN, Karmeli F, Shina A, Rachmilewitz D, Brezis M. The effect of contrast media (CM) on intrarenal nitric oxide synthase activity. J Am Soc Nephrol 8:330A, 1997.
37. Bitz H, Darmon D, Goldfarb M, Shina A, Rosen S, Block C, Heyman S, Brezis M. Vulnerability to pyelonephritis after relief of ureteral obstruction. J Am Soc Nephrol 8:611A, 1997.
38. Heyman SN, Ginosar Y, Niel L, Jacob Amir, MD, Marx N, Shapiro M, Maayan S. Meningococcal meningitis among Rwandan refugees: diagnosis, management and outcome in a field hospital. Annual meeting of the Israeli Association for Emergency Medicine, 1998.
39. Heyman SN, Ginosar Y, Shapiro M, Kluger Y, Marx N, Maayan S. Diarrheal epidemics among Rwandan refugees, 1994: management and outcome in a field hospital. Annual meeting of the Israeli Association for Emergency Medicine, 1998.
40. Heyman SN, Darmon D, Bitz H, Brezis M, Shina A, Rosen S. Selective cyclooxygenase (COX)-2 inhibition adversely affects function and morphology in the isolated perfused rat kidney. J Am Soc Nephrol, 9:595A, 1998.
41. Heyman SN, Godfarb M, Darmon D, Brezis M. The role of nitric oxide (NO) and endothelin (ET) in renal microcirculatory response to endotoxin. J Am Soc Nephrol, 9:338A-339A, 1998.
42. Reichman J, Cohen S, Shina A, Brezis M, Rosen S, Heyman SN. Renal safty of nabumetone, a predominantly selective cyclooxygenase (COX)-2 inhibitor. Acute and chronic studies in rats. J Am Soc Nephrol 10:651A, 1999.
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43. Goldfarb M, Abassi Z, Darmon D, Shina A, Brezis M, Rosen S, Heyman SN. Chronic heart failure predisposes to hypoxic outer medullary tubular injury: studies in rats. J Am Soc Nephrol 10:631A, 1999.
44. Yanko R, Raz I, Brezis M, Heyman SN. Hyperglycemia directly induces renal vasodilation in anesthetized rats: a role for nitric oxide? J Am Soc Nephrol 10:391A, 1999.
45. Reichman J, Shina A, Rosen S, Brezis M, Heyman SN. Nabumetone, a selective cyclooxygenase (COX)-2 inhibitor, is free of renal adverse effects. Studies in anesthetized rats. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 825, 1999.
46. Reichman J, Shina A, Darmon D, Brezis M, Rosen S, Heyman SN. Selective cyclooxygenase (COX)-2 inhibition adversely affects function and morphology in the isolated perfused rat kidney. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 824, 1999.
47. Heyman SN, Godfarb M, Darmon D, Brezis M. The role of nitric oxide (NO) and endothelin (ET) in renal microcirculatory response to endotoxin. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 481, 1999.
48. Heyman SN, Goldfarb M, Darmon D, Brezis M. Tissue oxygenation modifies nitric oxide bioavailability. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 416, 1999.
49. Ofran Y, Stalnikowitz R, Heyman SN. Peripheral vasospasm secondary to the combined effects of cocaine, ergotamine and beta-blockers. 11 th Scientific meeting of the Israeli Society of Toxicology, March, 2000.
50. Heyman SN, Shina A, Spokes K, Brezis M, Rosen S. Proximal tubular injury attenuates outer medullary hypoxic damage. Studies in the isolated perfused kidney. J Am Soc Nephrol 11:601A, 2000.
51. Heyman SN, Shina A, Goldfarb M, Rosen S. N-acetylcysteine (NAC) ameliorates renal microcirculation. J am Soc Nephrol 12:781A-782A, 2001
52. Goldfarb M, Rosen S, Shina A, Heyman SN. The effect of poly-(ADP-Ribose) polymerase (PARP) inhibition with 3-Aminobenzamide (3-AB) on outer medullary hypoxic damage. J am Soc Nephrol 12:780A, 2001
53. Heyman SN, Shina A, Zohair H, Goldfarb M, Rosen S, Higazi AAR. The Fibrinolytic System and Renal Hemodynamics: Studies in Rats J Am Soc Nephrol 13:336A, 2002
54. Heyman SN, Shina A, Goldfarb M, Rosen S. The Effect of Nicotine on the Renal Microcirculation in Anesthetized Rats: a potential for medullary hypoxic injury. J Am Soc Nephrol 13:333A, 2002
55. Goldfarb M, Rosen S, Shina A, Heyman SN. Acute renal failure superimposed on pre-existing tubulointerstial disease in rats: contribution of both chronic and acute tubular damage to renal dysfunction. J Am Soc Nephrol 13:547A, 2002
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56. Rosenberger C, Heyman SN, Rosen S, Frei U, Bachmann S, Eckardt KU. Expression of hypoxia-inducible-factors-1alpha and 2alpha in acute renal failure. J Am Soc Nephrol 13:136A-137A, 2002
57. Abassi Z, Francis BN, Heyman SN, Winaver J, Hoffman A. Differential regulation of ETA and ETB in the renal tissue of rats with compensated and decompensated heart failure Eighth International Conference on Endothelin, Tsukura, Japan 2003
58. Rosen S, Rosenberger C, Heyman SN. The Human Renal Biopsy in ATN Versus Animal Models of ATN: Conflicts and agreements. ARF satellite symposium, International Society of Nephrology Meeting, Berlin 2003.
59. Heyman SN. Renal medullary hypoxia: physiology and pathophysiology. The annual meeting of the Israel Society for physiology and pharmacology, A2, Maale hahamisha, Israel, 2003
60. Argov E, Netz Y, Brown R, Burstin A, Heyman S N. Exercise as a modifier of physical frailty and well-being in functionally impaired nursing home residents - the use of a standing device. 8th congress of the European Federation for Research in Rehabilitation, Lublijana, Slovenia, 2004
61. Cohen R, Safadi R, Heyman SN. A brief problem-based learning experience for students prior to entering the clinical clerkship phase of training. Faculty Development and Professionalism in Medical Education meeting, Tel Aviv, 2004.
62. Heyman SN, Rosenberger C, Shina A, Goldfarb M, Eckardt KU, Rosen S. Cell-specific expression of hypoxia-inducible transcription factors (HIF) in the isolated perfused kidney. J Am Soc Nephrol 15:254A, 2004
63. Heyman SN, Abassi Z, Khamaisi M, Shina A, Goldfarb M, Rosen S. Rosenberger C. Diabetes predisposes to medullary hypoxia with activation of hypoxia inducible factors (HIF) and upregulation of endothelin-B receptors (ETB). J Am Soc Nephrol 15:468A, 2004
64. Damianovich M, Heyman SN, Rosen S, Shina A, Reshef A, Kevin G, Grimberg H, Aloya R, Cohen A, Ziv I, Shirvan A. Apoptosis-sensor: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. J Am Soc Nephrol 15:718A, 2004
65. Maril N, Heyman SN, Rosen S, Degani H. 23Na MRI Study of the Renal Sodium Distribution at an Early Phase of ARF in the Intact Rat Kidney. J Am Soc Nephrol 15:461-2A, 1004
66. Shirvan A, Damianovich MD, Heyman SN, Rosen S, Shina A, Reshef A, Kevin G, Grimberg H, Aloya R, Cohen A, Ziv I. Functional molecular imaging of cell death in models of acute renal tubular necrosis. The Society of Molecular Imaging (SMI) conference, St. Lewis, 2004
67. Goldfarb M, Shina A, Rosen S, Heyman SN. Erythropoietin Attenuates Radiocontrast-Induced Acute Renal Failure in Rats. Israeli Society of Nephrology meeting, Eilat, March 2005
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68. Heyman SN. The The Effect of nicotine on the renal microcirculation in anesthetized rats: a potential for medullary hypoxic injury. Israeli Society of Toxicology meeting, Ramat gan, May 2005
69. Heyman SN, Rosenberger C, Shina A, Shilo V, Eckardt KU, Rosen S. Renal Medullary Hypoxic Damage in the Diabetic Rat: Studies in Vivo and in Isolated Perfused Kidneys. J Am Soc Nephrol 16:402A, 2005
70. Goldfarb M, Shina A, Rosenberger C, Rosen S, Heyman SN. Attenuation of Radiocontrast-Induced Nephropathy (CIN) in the Rat By Erythropoietin (EPO). J Am Soc Nephrol 16:621A, 2005
71. Rosenberger C, Goldfarb M, Abassi Z, Shina A, Eckardt KU, Rosen S, Heyman SN. Acute-On-Chronic Renal Failure (RF) in the Rat: Functional Compensation and Hypoxia. J Am Soc Nephrol 16:621A, 2005
72. Heyman SN. Hypoxia and Hypoxia adaptation in the diabetic rat kidney. D-CURE Annual Meeting, Weitzman's Institute, Rehovot, Israel, 2006.
73. Heyman SN. Hypoxia and Hypoxia adaptation in the diabetic rat kidney. D-CURE Annual Meeting, Weitzman's Institute, Rehovot, Israel, 2006.
74. Rosenberger C, Shina A, Goldfarb M, Rosen S, Heyman SN. Heyman SN. Sustained Hypoxia and Hypoxia Adaptation in Rhabdomyolysis-Induced Acute Kidney Injury. World Congress of Nephrology, Rio De Janeiro, April 2007
75. Khamaisi M, Raz I, Rosenberger C, Meidan R, Abassi Z, , Shilo V, Heyman SN. The effect of diabetes and radiocontrast media on renal expression of endothelin converting enzyme-1. Endothelin Conference, Beragmo, Italy 2007
76. Khamaisi M, Shilo V, Rosenberger C, Goldfarb M, Shina A, Meidan R, Raz I, Heyman SN. Diabetes and radiocontrast medium induce converting enzyme (ECE)-1 in vitro and in the renal medulla: a plausible novel mechanism for elevated endothelin. J Am Soc Nephrol 18:166A, 2007
77. Heyman SN, Shina A, FillPin LA, Arend M, Klaus SJ, Eckardt KU, Rosen S, Rosenberger C. Activation of hypoxia inducible factors (HIF) ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. J Am Soc Nephrol 18:645A, 2007
78. Paliege A, Rosenberger C, Heyman SN, Klaus SJ, Moreira L, Bachmann S. Stimulation of autochthonous renal erythropoietin expression by prolyl hydroxylase inhibition. Anatomische Gesellschaft 103rd meeting, Innsbruck, Austria, March 2008
79. Karram T, Bishara B, Ramadan R, Abu-Saleh N, Heyman S, Winaver J, Hoffman A, Abassi Z. Expression of endothelin ETA and ETB receptors in human kidney: Possible source of urinary ETA and ETB . JASN, 19:609A, 2008
80. Heyman SN. Activation of Hypoxia Inducible Factors (HIF) ameliorates hypoxic distal tubular injury in isolated perfused rat kidneys. Israeli Society of Nephrology and Hypertension, Annual Meeting, Eilat, March 2008
81. Khamaisi M, Axelrod J, Rosenberger C, Heyman SN. Endothelin converting enzyme (ECE)-1: a plausible target gene for hypoxia inducible factor (HIF). Endothelin Conference, Montréal, 2009
82. Nechemia-Arbeli Y, Rosenberger C, Khamaisi M, Koesters R, Shina A, Klaus S, Shriki A, Rosen S, Axelrod JH, Heyman SN. Renal hypoxia inducible factors (HIF) and STAT3 cross talk in vivo. Am Soc Nephrol annual meeting, San Diego, Nov 2009
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83. Paliege A, Rosenberger C, Bondke A, Sciesielski L, Heyman S, Flippin L, Arend M,
Klaus S, Bachmann S. Stimulation of renal erythropoietin expression by HIF prolyl hydroxylase inhibition is confined to HIF-2 alpha-expressing fibroblasts. Erythropoietin conference, Luebeck, Germany, 2009
84. Khamaisi M, Axelrod J, Karry R, Shina A, Heyman SN. Endothelin Converting Enzyme (ECE)-1: a Plausible Target Gene for Hypoxia Inducible Factor (HIF). Israeli Society of Nephrology and Hypertension, Annual Meeting, Kfar Bloom, April 2010
85. Milman Z, Axelrod J, Heyman S, Corchia N, Abramovitch R. Advanced magnetic resonance imaging (MRI) for the assessment of rhabdomyolysis-induced acute kidney injury (AKI) in mice. ISN world congress, Vancouver, Canada, 2011
86. Milman Z, Axelrod J, Heyman S, Corchia N, Abramovitch R. Assessment of rhabdomyolysis-induced acute kidney injury (AKI) in mice using Hemodynamic Response Imaging (HRI). International Society for Magnetic Resonance in Medicine (ISMRM) annual meeting, Montreal, 2011
87. Milman Z, Axelrod J, Heyman S, Corchia N, Abramovitch R. Advanced MRI methods for the differentiation and characterization of acute and chronic kidney diseases. International Society for Magnetic Resonance in Medicine (ISMRM) annual meeting, 2012
88. Milman Z, Heyman SN, Axelrod JH, Corchia N, Abramovitch R. Advanced Magnetic Resonance Imaging (MRI) methods for kidney imaging. Israeli Society of Nephrology and Hypertension, Annual Meeting, Keisaria, April 2012
89. Milman Z, Heyman SN, Axelrod JH, Corchia N, Abramovitch R. Assessment of Renal Morphology and Hemodynamics in Acute and Chronic Kidney Failure with Advanced Unenhanced Magnetic Resonance Imaging (MRI) Techniques. Am Soc Nephrol annual meeting, San Diego 2012
90. Khamaisi M, Mimura I, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Koesters R, Rosen S, Walkinshaw G, Nangaku M, Heyman SN. Endothelin converting enzyme (ECE)-1: a plausible target gene for hypoxia inducible factor (HIF). Am Soc Nephrol annual meeting, San Diego 2012
91. Khamaisi M, Rosenberger C, Toukan H, Shina A, Skarjinski G, Axelrod J, Abramowitz R, Milman Z, Rosen S, Mimura I, Nangaku M, Heyman SN. On cyclosporine A, renal hypoxia and endothelin converting enzyme (ECE)-1. Israeli Society of Nephrology and Hypertension, Annual Meeting, Keisaria, April 2013
92. Abassi Z, Sohotnik R, Nativ O, Frajewicki V, Armaly Z, Bishara B, Heyman S, Sokhotnik I, Awad H, Nativ O. Phosphodiesterase5 inhibition protects against ischemia-reperfusion-induced acute kidney injury. Israeli Society of Nephrology and Hypertension, Annual Meeting, Keisaria, April 2013
93. Schley G, Cordasic N, Klanke B, Heyman SN, Rosen S, Eckardt KU, Willam K. Evidence for primary endothelial cell injury and subsequent scarring in a mouse model of radiocontrast nephropathy. ASN annual meeting, Atlanta, 2013
94. Abu-Saleh N, Awad H, Khamaisi M, Karram T, Heyman SN, Abassi Z. Nephroprotective Effects of TVP1022, a non–MAO inhibitor S-Isomer of Rasagiline, in
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Experimental Model of Diabetic Renal Ischemic Injury. ASN Annual meeting, Atlanta 2013
95. Lossos A, Teltsh O, Milman T, Meiner V, Rozen, Leclerc D, Watkins D, Rosenblatt DS, Shaag A, Korman SH, Heyman SH, Kohn S. SEVERE METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) DEFICIENCY: A POTENTIALLY TREATABLE CAUSE OF LATE-ONSET SPASTIC PARAPLEGIA. Israeli Neurological Association Annual Meeting 2013
96. David S Gertz, Eisenkroft A, Shapira S, Heyman SN, Leitersdorf E, Harta Ml, Yaniv G, Kreiss Y. Establishment of the Israel Institute for Research in Military Medicine: New Opportunities for Improvement of Management of Extreme Disasters. IPRED-III, Jan 2014, Israel
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Submitted articles 1. Khamaisi M, Mimora I, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G,
Koesters R, Meidan R, Rosen S, Walkinshaw G, Nangaku M, Heyman SN. Endothelin converting enzyme (ECE)-1: a plausible target gene for hypoxia inducible factor (HIF)
Articles in preparation1. Heyman L, Houri Haddad Y, Feruerstein O, Heyman SN, Ginsburg I. The
efficacy of Neem-tree (Azadirachta Indica) leaf extract against periopathogenic pathogens: a role for antioxidant capacity
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