Sakura webinar seriesAutoSection®

Target groups

Mascha van Sikkelerus

31-05-2016

Agenda

1 AutoSection Success: recut market

3 AutoSection new target market: standardization

4 AutoSection new target market: RMD

AutoSection: USP features

USP 1

AutoAlignPay-Off: Preserves valuable tissue of re-cuts due to automated block alignment

USP 2

Pre-set programsPay-Off: Precise and consistent high-quality sectioning for every technician and tissue type

USP 3

AutoTrimPay-Off: Improved productivity &a decrease in repetitive stress disorders (RMD) for users

Success: Recut market

Target Group: High volume recutsThe AutoSection is the only microtome to preserve tissue by auto aligning the block to blade automatically without sacrificing tissue.

DMU Need Feature BenefitsTechnician Fast /easy

alignmentAutoAlign • Quick alignment without time consuming manual

chuck adjustments. • Less stress.

Pathologist Less tissue loss

AutoAlign • Preserves tissue for pathologist / More slides for diagnosis per block.

AutoAlignment = Preservation of valuable tissue

Target group: Standardization

AutoSection & Standardization

Research* until so far has shown, that AutoSection is;

• The most accurate and

• The most precise microtome

in the market.

* research is done by Sakura

AutoSection & Standardisation

What did we measure?Chuck displacement at various settings

How did we measure? We determined the displacement by laser measurements

Mean and SD AutoSection, SRM, Leica RM2255

Microtome Serial # Setting Mean SD Min Max Setting Mean SD Min Max Setting Mean SD Min Max

AutoSection AP008 3.0 2.81 0.16 2.6 3.1 4.0 4.02 0.27 3.5 4.4 5.0 5.00 0.33 4.5 5.4

SRM 400 42827 3.0 2.84 0.67 1.7 4.3 4.0 4.04 0.73 3 5.7 5.0 5.09 0.70 4.1 6.4

Leica RM2255 3.0 3.19 0.46 2.6 3.9 4.0 4.21 0.66 3.3 5.2 5.0 5.03 0.96 3.7 6.6

Microtome Serial # Setting Mean SD Min Max

AutoSection AP006 0.5 0.54 0.17 0.2 0.8

SRM200 #1 10046 0.5 0.77 0.41 0.3 1.6

SRM200 #2 0.5 1.23 1.43 0.4 3.5

SRM 400 42827 0.5 0.98 0.25 0.6 1.4

Leica RM2255 0.5 1.10 0.15 0.8 1.4

3.192.73 3.65-SD +SD

0.92

What does this mean for the customer? (1)

Standardization Consistency more accurate diagnosis

H&E:Difference in thickness = difference in the color.

IHC: Control tissueDifference in thinkness = different intensity of the stain

What does this mean for the customer? (2)

ISH FISH and CISHScore the signals in the cell

Inconsistency in the thickness can result in more inaccurate diagnosis.

Top view

Side view 1. Positive result

or

Side view 2. Thicker section than expected

AutoSection & Standardization

More consistency in chuck movement of the AutoSection:

• More standardization in slides.

• Done by everyone and not only the experienced technicians.

• Easier to get accurate diagnosis

Consistency = more accurate diagnosis

Target group of standardization: Pathologist & Lab manager

DMU Need Feature Benefits

Pathologist Standardization Programming • Consistency in sectioning More accurate diagnoses.

Pathologist Enough tissue to diagnose AutoAlign • Prevent losing valuable tissue.

Pathologist consistent sectioning Automation • Reduced QC rejected slides.• More accurate diagnoses.

Lab manager Standardization Programming • Every technician is doing the same = Consistency in sectioning

Automation, Pre-set programs &

AutoAlignment = Standardization

Target group: Repetitive Stress Motion Disease (RMD)

Target market: RMD

Target Group: RMDlabs concerned with repetitive stress motion disease (RMD)

StatementThe AutoSection is a microtome that prevents repetitive stress motion disease by there fully automated microtomy.

DMU Need Feature BenefitsTechnician Pain free work Fully automated

sectioning• Get your sections without cranking a hand

wheel.Technician Stress less work Flexible sectioning

programs• Automates the way of sectioning while

staying in control. Lab manager Less stress Fully automated

sectioningPre programmable sectioning

• No judgement call between the different experiences/skills of the technicians

• Less sick leave

Repetitive Motion Disorders

From 2011-2013 Sweden:

• 1900 women + 1300 men reported workrelated illness due to RMD = 3200 persons

• Women aged 45 – 54 years = 52%

• An increase of 28% compared to 2009

• This is equivalent to 21% of all work related illness

Challenges: Repetitive motions

• 2 million rotations per yearaverage of 50 blocks/day are cut

• Quality of life and workRMD is not only painful, but it also affects the technician's quality of life. Ultimately, it disrupts work schedules, productivity, and is expensive for the laboratory.

• Each worker compensation claim for repetitive stress injuries can cost up to $20,000 - $100,000. Consumer Watch Report, PC World.

Repetitive motions reduction:Solutions in the market place

2.000.000hand wheel revolutions a year

AutomationOne-touch operation

Fully automated sectioning= pain free microtomy

Testimonial Aarhus Hospital

Highlights:

• Recuts

• Efficiency

• Preservation of valuable tissue

• Programming

• RMD “One of the major disadvantages of our manual microtomesis the positioning of your arms and shoulders. While you alignthe block and section, it causes stress induced pain in the neckand shoulders. These problems are eliminated by AutoSection,because the alignment is done automatically.”

“It replaces manual orientation of the block, leading to standardized and most accurate block alignment for every lab technician: beginner or advanced.”

“With AutoSection not only we get optimal results, we are also saving a lot of time and preventing the loss of valuable tissue”.

“It’s definitely ground breaking in doing recuts, she continues, The risk of losing valuable tissue has dramatically decreased”.

Summary

Fully automated sectioning= pain free microtomy

Consistency = more accurate diagnosis

Automation, Pre-set programs &

AutoAlignment = Standardization

AutoAlignment = Preservation of valuable tissue

AutoSection = the most accurate and precise microtome

AutoSection…Too slow???

AutoSection

Wrap-up

• Evaluation form will appear immediately after this webinar

• You will receive a copy of this presentation

• For questions contact: Sakura Academy

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Thank you for attending thisSakura Academy webinar

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