SAFETY DATA SHEET

1. IdentificationTissue-Tek® Paraform® Orientation GelsProduct identifier

Other means of identificationTissue-Tek® Paraform® Biopsy Gels (Product code #7045), Tissue-Tek® Paraform® 2-Lane Gels(Product code #7046), Tissue-Tek® Paraform® 1-mm Punch Gels (Product code #7047),Tissue-Tek® Paraform® 2-mm Punch Gels (Product code #7048), Tissue-Tek® Paraform® 3-mmPunch Gels (Product code #7049)

Product code

Hydrogel * Tissue Orientation GelSynonymsFor tissue processing.Recommended useNone known.Recommended restrictions

Manufacturer/Importer/Supplier/Distributor informationManufacturer/Supplier Sakura Finetek USA Inc.

Address 1750 West 214th St.Torrance, CA 90501

Telephone 1-310-972-7800Emergency phone number CHEMTREC: 1-800-424-9300Email SDSsupport@sakuraus.com

2. Hazard(s) identificationNot classified.Physical hazards

Category 1BReproductive toxicityHealth hazards

Not classified.OSHA defined hazards

Label elements

Signal word DangerHazard statement May damage fertility or the unborn child.Precautionary statement

Prevention Obtain special instructions before use. Do not handle until all safety precautions have been readand understood. Wear protective gloves/protective clothing/eye protection/face protection.

Response If exposed or concerned: Get medical advice/attention.Storage Store locked up.Disposal Dispose of contents/container in accordance with local/regional/national/international regulations.

Hazard(s) not otherwiseclassified (HNOC)

None known.

Supplemental information None.

3. Composition/information on ingredientsMixtures

7732-18-5 70-99Water

CAS number %Chemical name

Proprietary <30Proprietary carbohydratematrix (dried)

1303-96-4 0-1Sodium tetraboratedecahydrate

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99-76-3 0-0.5Methyl paraben

Chemical ingredient identity and/or concentration information withheld for some or all componentspresent is confidential business information (trade secret), and is being withheld as permitted by29 CFR 1910.1200(i).

Composition comments

4. First-aid measuresIf breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.Call a physician if symptoms develop or persist.

Inhalation

Rinse skin with water/shower. Get medical attention if irritation develops and persists.Skin contactRinse with water. Get medical attention if irritation develops and persists.Eye contactRinse mouth. If ingestion of a large amount does occur, call a poison control center immediately.IngestionDirect contact with eyes may cause temporary irritation.Most important

symptoms/effects, acute anddelayed

Provide general supportive measures and treat symptomatically. Keep victim under observation.Symptoms may be delayed.

Indication of immediatemedical attention and specialtreatment needed

IF exposed or concerned: Get medical advice/attention. If you feel unwell, seek medical advice(show the label where possible). Ensure that medical personnel are aware of the material(s)involved, and take precautions to protect themselves. Show this safety data sheet to the doctor inattendance.

General information

5. Fire-fighting measuresWater fog. Foam. Dry chemical powder. Carbon dioxide (CO2).Suitable extinguishing mediaDo not use water jet as an extinguisher, as this will spread the fire.Unsuitable extinguishing

mediaDuring fire, gases hazardous to health may be formed.Specific hazards arising from

the chemicalSelf-contained breathing apparatus and full protective clothing must be worn in case of fire.Special protective equipment

and precautions for firefightersUse water spray to cool unopened containers.Fire fighting

equipment/instructionsUse standard firefighting procedures and consider the hazards of other involved materials.Specific methodsNo unusual fire or explosion hazards noted.General fire hazards

6. Accidental release measuresKeep unnecessary personnel away. For personal protection, see section 8 of the SDS.Personal precautions,

protective equipment andemergency procedures

Large Spills: Stop the flow of material, if this is without risk. Shovel up and place in a container forsalvage or disposal. Following product recovery, flush area with water.

Small Spills: Scoop up released material. Clean surface thoroughly to remove residualcontamination.

Never return spills to original containers for re-use. For waste disposal, see section 13 of the SDS.

Methods and materials forcontainment and cleaning up

Avoid discharge into drains, water courses or onto the ground.Environmental precautions

7. Handling and storageObtain special instructions before use. Do not handle until all safety precautions have been readand understood. Provide adequate ventilation. Avoid prolonged exposure. Pregnant orbreastfeeding women must not handle this product. Should be handled in closed systems, ifpossible. Wear appropriate personal protective equipment. Observe good industrial hygienepractices.

Precautions for safe handling

Store locked up. Store in original tightly closed container. Store away from incompatible materials(see Section 10 of the SDS).

Conditions for safe storage,including any incompatibilities

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8. Exposure controls/personal protectionOccupational exposure limits

US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000)

ValueType FormComponentsPEL 5 mg/m3 Respirable fraction.Proprietary carbohydrate

matrix (dried) (CASProprietary)

15 mg/m3 Total dust.

US. ACGIH Threshold Limit Values

ValueType FormComponentsTWA 10 mg/m3Proprietary carbohydrate

matrix (dried) (CASProprietary)

STEL 6 mg/m3 Inhalable fraction.Sodium tetraboratedecahydrate (CAS1303-96-4)

TWA 2 mg/m3 Inhalable fraction.

US. NIOSH: Pocket Guide to Chemical Hazards

ValueType FormComponentsTWA 5 mg/m3 Respirable.Proprietary carbohydrate

matrix (dried) (CASProprietary)

10 mg/m3 TotalTWA 5 mg/m3Sodium tetraborate

decahydrate (CAS1303-96-4)

No biological exposure limits noted for the ingredient(s).Biological limit valuesGood general ventilation (typically 10 air changes per hour) should be used. Ventilation ratesshould be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.

Appropriate engineeringcontrols

Individual protection measures, such as personal protective equipmentIf contact is likely, safety glasses with side shields are recommended.Eye/face protection

Skin protectionWear appropriate chemical resistant gloves. Suitable gloves can be recommended by the glovesupplier.

Hand protection

Use of an impervious apron is recommended.OtherWhen workers are facing concentrations above the exposure limit they must use appropriatecertified respirators.

Respiratory protection

Wear appropriate thermal protective clothing, when necessary.Thermal hazardsAlways observe good personal hygiene measures, such as washing after handling the materialand before eating, drinking, and/or smoking. Routinely wash work clothing and protectiveequipment to remove contaminants.

General hygieneconsiderations

9. Physical and chemical propertiesAppearance

Solid (Semi-solid).Physical stateGel.FormBlue. ColorNot available.Odor

Odor threshold Not available.pH Not available.Melting point/freezing point Not available.Initial boiling point and boilingrange

Not available.

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Flash point Not available.Evaporation rate Not available.

Combustible solid.Flammability (solid, gas)Upper/lower flammability or explosive limits

Flammability limit - lower(%)

Not available.

Flammability limit - upper(%)

Not available.

Explosive limit - lower (%) Not available.Explosive limit - upper (%) Not available.

Vapor pressure Not available.Vapor density Not available.Relative density Not available.Solubility(ies)

Solubility (water) Not available.Partition coefficient(n-octanol/water)

Not available.

Auto-ignition temperature Not available.Decomposition temperature Not available.Viscosity Not available.Other information

Not explosive.Explosive propertiesNot oxidizing.Oxidizing properties

10. Stability and reactivityThe product is stable and non-reactive under normal conditions of use, storage and transport.ReactivityMaterial is stable under normal conditions.Chemical stabilityNo dangerous reaction known under conditions of normal use.Possibility of hazardous

reactionsContact with incompatible materials.Conditions to avoidStrong oxidizing agents. Acids. Bases.Incompatible materialsNo hazardous decomposition products are known.Hazardous decomposition

products

11. Toxicological informationInformation on likely routes of exposure

Inhalation Prolonged inhalation may be harmful.

Skin contact No adverse effects due to skin contact are expected.

Eye contact Direct contact with eyes may cause temporary irritation.

Ingestion Expected to be a low ingestion hazard.

Symptoms related to thephysical, chemical andtoxicological characteristics

Direct contact with eyes may cause temporary irritation.

Information on toxicological effectsAcute toxicity Not expected to be acutely toxic.

Test ResultsComponents SpeciesSodium tetraborate decahydrate (CAS 1303-96-4)

LD50 RabbitDermalAcute

> 10000 mg/kg

LD50 RatOral

5.66 g/kg

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Prolonged skin contact may cause temporary irritation.Skin corrosion/irritationDirect contact with eyes may cause temporary irritation.Serious eye damage/eye

irritationRespiratory or skin sensitization

Respiratory sensitization Not a respiratory sensitizer.This product is not expected to cause skin sensitization.Skin sensitizationNo data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.

Germ cell mutagenicity

Carcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.

IARC Monographs. Overall Evaluation of CarcinogenicityNot listed.

NTP Report on CarcinogensNot listed.

OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)Not listed.

May damage fertility or the unborn child.Reproductive toxicitySpecific target organ toxicity -single exposure

Not classified.

Specific target organ toxicity -repeated exposure

Not classified.

Aspiration hazard Not an aspiration hazard.

Chronic effects Reproductive hazard.

12. Ecological informationThe product is not classified as environmentally hazardous. However, this does not exclude thepossibility that large or frequent spills can have a harmful or damaging effect on the environment.

Ecotoxicity

No data is available on the degradability of this product. Persistence and degradabilityNo data available.Bioaccumulative potentialNo data available.Mobility in soil

Other adverse effects No other adverse environmental effects (e.g. ozone depletion, photochemical ozone creationpotential, endocrine disruption, global warming potential) are expected from this component.

13. Disposal considerationsCollect and reclaim or dispose in sealed containers at licensed waste disposal site. Dispose ofcontents/container in accordance with local/regional/national/international regulations.

Disposal instructions

Dispose in accordance with all applicable regulations.Local disposal regulationsThe waste code should be assigned in discussion between the user, the producer and the wastedisposal company.

Hazardous waste code

Dispose of in accordance with local regulations. Empty containers or liners may retain someproduct residues. This material and its container must be disposed of in a safe manner (see:Disposal instructions).

Waste from residues / unusedproducts

Since emptied containers may retain product residue, follow label warnings even after container isemptied. Empty containers should be taken to an approved waste handling site for recycling ordisposal.

Contaminated packaging

14. Transport informationDOT

Not regulated as dangerous goods.IATA

Not regulated as dangerous goods.IMDG

Not regulated as dangerous goods.Not applicable.Transport in bulk according to

Annex II of MARPOL 73/78 andthe IBC Code

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15. Regulatory informationThis product is a "Hazardous Chemical" as defined by the OSHA Hazard CommunicationStandard, 29 CFR 1910.1200.

US federal regulations

TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)Not regulated.

OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)Not listed.

CERCLA Hazardous Substance List (40 CFR 302.4)Not listed.

Superfund Amendments and Reauthorization Act of 1986 (SARA)Immediate Hazard - NoDelayed Hazard - YesFire Hazard - NoPressure Hazard - NoReactivity Hazard - No

Hazard categories

SARA 302 Extremely hazardous substanceNot listed.

YesSARA 311/312 HazardouschemicalSARA 313 (TRI reporting)

Not regulated.

Other federal regulationsClean Air Act (CAA) Section 112 Hazardous Air Pollutants (HAPs) List

Not regulated.Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130)

Not regulated.Not regulated.Safe Drinking Water Act

(SDWA)US state regulations

US. Massachusetts RTK - Substance ListProprietary carbohydrate matrix (dried) (CAS Proprietary)Sodium tetraborate decahydrate (CAS 1303-96-4)

US. New Jersey Worker and Community Right-to-Know ActSodium tetraborate decahydrate (CAS 1303-96-4)

US. Pennsylvania Worker and Community Right-to-Know LawProprietary carbohydrate matrix (dried) (CAS Proprietary)Sodium tetraborate decahydrate (CAS 1303-96-4)

US. Rhode Island RTKNot regulated.

US. California Proposition 65California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): This material is not known to containany chemicals currently listed as carcinogens or reproductive toxins.

International InventoriesCountry(s) or region Inventory name On inventory (yes/no)*

Australian Inventory of Chemical Substances (AICS) YesAustraliaDomestic Substances List (DSL) YesCanadaNon-Domestic Substances List (NDSL) NoCanadaInventory of Existing Chemical Substances in China (IECSC) YesChinaEuropean Inventory of Existing Commercial ChemicalSubstances (EINECS)

YesEurope

European List of Notified Chemical Substances (ELINCS) NoEuropeInventory of Existing and New Chemical Substances (ENCS) YesJapanExisting Chemicals List (ECL) YesKoreaNew Zealand Inventory YesNew Zealand

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Country(s) or region Inventory name On inventory (yes/no)*Philippine Inventory of Chemicals and Chemical Substances(PICCS)

YesPhilippines

*A "Yes" indicates this product complies with the inventory requirements administered by the governing country(s).A "No" indicates that one or more components of the product are not listed or exempt from listing on the inventory administered by the governingcountry(s).

Toxic Substances Control Act (TSCA) Inventory YesUnited States & Puerto Rico

16. Other information, including date of preparation or last revision6-JUN-2014Issue date15-JAN-2016Revision date

Version # DHMIS® is a registered trade and service mark of the American Coatings Association (ACA).Further informationHealth: 1*Flammability: 1Physical hazard: 0

HMIS® ratings

NFPA ratings

011

Sakura Finetek USA Inc. cannot anticipate all conditions under which this information and its product, or the products of other manufacturers in combination with its product, may be used. It is the user’s responsibility to ensure safe conditions for handling, storage and disposal of the product, and to assume liability for loss, injury, damage or expense due to improper use. The information in the sheet was written based on the best knowledge and experience currently available.

Disclaimer

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