S-Adenosylmethionine (SAMe) and Silybin A+B

Denamarin contains SAMe and Silybin A+B andis available in chewable and enteric-coated tablets.

Chewable tabletFor Dogs of All Sizes

Large Dogtablet

Medium Dogtablet

Cat/Small Dogtablet

PolymodalAction

Two Actives — One Patented Formula

The Right Combination for Pets Requiring Enhanced Liver Support

DenamarinThe #1 Veterinarian

RecommendedLiver Support Brand

Comprehensive Liver Support

º Combining the benefits of two active ingredients SAMe and Silybin A+B in one tablet

º When using medications that may be potentially hepatotoxic1

º When maximum liver support is needed

Promotes Liver Support and Protection

º SAMe increases glutathione levels and protects against cell death

º Silybin A+B acts as an antioxidant, helping protect against reactive oxygen compounds

Chewable Tablets Available º Increase compliance, no need to “pill”

º Scored, chewable tablets for dogs of all sizes

Cost Effective

º Costs less than using Denosyl & Marin separately

º Dispensing sizes available

º Mail-in rebates available online for Denamarin Chewable Tablets at Denamarin.com

Silybin A+Bfrom Marin

SAMefrom Denosyl

Source: Survey conducted in July 2012 of small animal veterinarians who recommended liver support brands.

ALL TABLETS SHOWN ACTUAL SIZE

More than just milk thistleThe Silybin A+B in Denamarin is in a phosphatidylcholine complex which increases bioavailability, reaching levels up to 4 times higher in dogs than 80% standardized milk thistle alone. Bioavailability of silybin phosphatidylcholine complex has also been demonstrated in cats.2

Published research spanning 2002–2012

& more to come!

Denamarin’s active ingredients have the most published research demonstrating liver health support.

For more information call 1-888-886-6442 or go to Denamarin.comEnroll now in the Nutramax Laboratories, Inc.

Veterinary Loyalty Program: nutramaxlabs.com/loyalty

S-Adenosylmethionine (SAMe) and Silybin A+B

Two Actives — One Patented Formula

03-1021-05

Source: Survey conducted in July 2012 of small animal veterinarians who recommended liver support brands.

Only Denamarin combines the benefitsof SAMe and Silybin in one tablet

S-Adenosylmethionine (SAMe):

º Increases glutathione levels in the liver and in RBCs

º Protects against liver cell death

º Protects RBCs from oxidative cell death

º Supports cell membrane fluidity

º Promotes protein synthesis

Silybin A+B:

º Acts as an antioxidant, helping protect against reactive oxygen compounds

º Stimulates bile flow, aiding in digestion and absorption of nutrients

º Promotes liver protein synthesis

º May enhance levels of glutathione for better detoxification

Plasma levels of silybin in dogs after oral administration ofSPC* versus oral administration of silymarin (milk thistle)

1. Skorupski KA, Hammond GM, Irish AM, et al. J Vet Intern Med 2011;25:838-845.2. Webb CB, Gustafson DL, Twedt DC. Intern J Appl Res Vet Med 2012;10(2):107-112.