Ryan Irvin CV • January 2017 • 1

CURRICULUM VITAE

Ryan Irvin, PhD, MS

Office Address University of Alabama at Birmingham Department of Epidemiology 1665 University Blvd, Room 220F Birmingham, AL 35294-0022

Mailing Address RPHB 220F 1530 3rd Ave S Birmingham, AL 35294-0022

Telephone 205.975.7672

Fax 205.934.8665

Email irvinr@uab.edu

Web http://www.soph.uab.edu/faculty/epi/ryan_irvin

Education 2008 PhD Epidemiology, University of Alabama at Birmingham, Birmingham AL.

Dissertation: Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder. Advisor: Rodney Go, rgo@uab.edu

2004 MS Biostatistics, Medical University of South Carolina, Charleston SC 1999 BS Biology with Honors, University of North Carolina, Chapel Hill, NC

Postdoctoral Training 2008 – 2011 Postdoctoral Fellow, joint appointment in Epidemiology and Section on Statistical

Genetics, University of Alabama at Birmingham, Birmingham AL. Research Focus: Genomics and pharmacogenomics of cardiovascular disease. Advisors: Donna K. Arnett, arnett@uab.edu; Hemant Tiwari, htiwari@uab.edu

Faculty Appointment 2011 – 2017 Assistant Professor, Department of Epidemiology, University of Alabama at

Birmingham School of Public Health, Birmingham, AL 2017 – Associate Professor, Department of Epidemiology, University of Alabama at

Birmingham School of Public Health, Birmingham, AL

Additional Professional Appointments 2013 – Associate Scientist, Comprehensive Cardiovascular Center, University of Alabama

at Birmingham, Birmingham, AL 2013 – Associate Scientist, Nutrition Obesity Research Center, University of Alabama at

Birmingham, Birmingham, AL 2015 – Associate Scientist, Comprehensive Arthritis, Musculoskeletal, Bone and

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Autoimmunity Center, University of Alabama at Birmingham, Birmingham, AL

Brief Chronology of Employment History 2004 – 2008 Project Manager and Multi-Site Coordinator, Department of Epidemiology,

University of Alabama at Birmingham. Supervisor: Rodney Go, rgo@uab.edu 2007 – 2008 PhD Candidate Research Assistant, Department of Biostatistics, University of

Alabama at Birmingham. Supervisor: Hemant Tiwari, htiwari@uab.edu 2000 – 2004 Statistical and Research Analyst II, Department of Pulmonary and Critical Care

Medicine, Medical University of South Carolina. Supervisor: Charlie Strange, strangec@musc.edu

1998 – 2000 Research Assistant, Department of Biology, University of North Carolina at Chapel Hill. Supervisor: Bob Duronio, duronio@med.unc.edu

Summer 1999 Intern National Institute of Environmental Health Sciences, Research Triangle Park, NC, Supervisor: Rick Paules, paules@niehs.nih.gov

Professional Societies 2006 International Genetic Epidemiology Society 2009 Nominated Member of AAAS/Science Program for Excellence in Science 2011 – 2017 American Heart Association

Teaching 2017 Course Co-Instructor, Analyzing Data and Publishing Findings in Large Cohort

Studies: REGARDS, BST 695 2015 – Course Instructor, Analysis of Case-Control Studies EPI 710 2011 Guest Lecturer Genetic Epidemiology EPI731 (2 sessions) 2012 Guest Lecturer Genetics in Public Health EPI635 (1 session) 2012 Guest Lecturer Graduate Biomedical Sciences GBS 721 (2 sessions) 2012 Guest Lecturer Cardiovascular Disease Epidemiology EPI606 (1 session) 2012 Guest Lecturer GBS 739-Neuropharmacology (1 session) 2012 Guest lecturer in Epidemiology Analysis of Follow-up Studies (720) (1 session) 2013 Guest Lecturer Graduate Biomedical Sciences GBS 721 (2 sessions) 2013 Guest Lecturer Methods Review in Epidemiology EPI781 (1 session) 2013 Guest Lecturer Pharmacoepidemiology EPI609 (1 session) 2013 Guest Lecturer Statistical Genetics BST775 (1 session) 2014 Guest Lecturer Genetic Epidemiology EPI 731 (1 session) 2015 Guest Lecturer Statistical Genetics BST775 (1 session) 2015 Guest Lecturer Genetics in Public Health EPI635 (1 session) 2015 Guest Lecturer Pharmacoepidemiology EPI609 (1 session) 2016 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session) 2017 Guest Lecturer Modeling Human Disease TMS 704/714/724 (1 session) 2017 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session) 2017 Guest Lecturer Genetic Epidemiology EPI 731 (2 sessions) 2018 Guest Lecturer Graduate Biomedical Sciences GBS 758 (2 sessions) 2018 Guest Lecturer Graduate Biomedical Sciences GBS 748 (1 session) 2018 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session)

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Mentoring Dissertation Committee Member

2013 – 2014 Guodong Wu, PhD, Department of Biostatistics, University of Alabama at Birmingham. Dissertation Title: Quantification and Association Analysis for Next-generation Sequencing Data

2013 – 2014 Rikki Tanner, PhD, MPH, Department of Epidemiology, University of Alabama at Birmingham. Dissertation Title: Association of Blood Pressure Phenotypes with Kidney Disease

2013 – 2016 Lindsay Jones, PhD, MS, Department of Biostatistics, University of Alabama at Birmingham. Dissertation Title: Statistical Methodology for DNA Methylation Array Analysis

2013 – 2016 Aditi Shendre, PhD, MPH, Department of Epidemiology, University of Alabama at Birmingham. Dissertation Title: Admixture mapping of subclinical and clinical cardiovascular disease among African Americans

2015 – 2016 Yogasudha Veturi, PhD, Department of Biostatistics, University of Alabama at Birmingham. Dissertation Title: Methods for analysis of genetic differences in sex and ethnicity for complex human traits

2015 –2018 Michael P Behring, PhD Candidate, Department of Epidemiology, University of Alabama at Birmingham. Dissertation Title: Multi-platform correlates of breast cancer metastasis, aging, and immune response

2016 –2017 Seth T Lirette, PhD Candidate, Department of Biostatistics, University of Alabama at Birmingham. Dissertation Title: Approaching brain perfusion data from a statistical perspective

2016 –2017 Carrie Huisingh, PhD Candidate, Department of Epidemiology, University of Alabama at Birmingham. Dissertation Title: Visual, Attentional, and Cognitive Risk Factors for Motor Vehicle Collision Involvement among Older Adults

2017 –2018 Allison C. Fialkowski, PhD Candidate, Department of Biostatistics, University of Alabama at Birmingham. Dissertation Title: Simulation of Correlated Variables, Mixture Distributions, and Repeated Measures and Comparison of Pharmacogenetic Prediction with Machine Learning Techniques.

Dissertation Committee Chair 2016 – 2017 Anh Do, PhD Candidate, Department of Epidemiology, University of Alabama at

Birmingham. Dissertation Title: Effects of antihypertensive drugs on left ventricular traits in African Americans

2018- Bre Minniefield, PhD Program, Graduate Biomedical Sciences, University of Alabama at Birmingham. Dissertation Title: Genomic Background of Blood Pressure Response to Thiazide Diuretic in African Americans-focus on Mitochondrial DNA and Admixture mapping (funded by Administrative supplement to 1R01HLHL123782)

2018- Ninad Chaudhary, PhD Program, Department of Epidemiology, University of

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Alabama at Birmingham. Dissertation Title: How Inflammation and High Density Lipoproteins Affect the

Relationship Between APOL1 and Outcomes (funded by AHA Award Number 18PRE34000021)

Master Thesis Committee Member 2013 – 2014 Anh Do, MSPH, Department of Epidemiology, University of Alabama at

Birmingham. Master’s Thesis Title: Pharmacogenetic effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes in response to antihypertensive treatments in the GenHAT study

2015 – 2016 Stephanie Ann Larocco, MSPH, Department of Epidemiology, University of Alabama at Birmingham. Master’s Thesis Title: Exomic background of incident cognitive impairment in elderly African-Americans

2015 – 2016 Anna Junkins, MSPH, Department of Epidemiology, University of Alabama at Birmingham Master’s Thesis Title: The association between apparent treatment resistant hypertension and quality of life, depressive symptoms and stress.

2017 Arnisha Atkins, MSPH, Department of Epidemiology, University of Alabama at Birmingham Master’s Thesis Title: Disparities in Breast and Colorectal Cancer Screenings in the United States by Medicaid Expansion

Master Thesis Committee Chair 2013 – 2014 Ngan Thanh Tran, MSPH, Department of Epidemiology, University of Alabama at

Birmingham. Master’s Thesis Title: PCSK9 variation and association with blood pressure in African Americans: Preliminary finding from the HyperGEN and REGARDS Project published in Frontiers in Genetics 2015

Co-mentor 2013 – 2014 Ngan Thanh Tran, MSPH student, Department of Epidemiology, University of

Alabama at Birmingham. Research Focus: Pharmacogenomics of Cardiovascular Disease Accomplishments: UAB Annual Public Health Research Day April 4, 2014 2nd Place for poster entitled “Interaction of PCSK9 variants with anthropometric traits on blood pressure in African Americans in the HyperGEN study.”

2014-2015 Mithun Das, Visiting Scholar, Assistant Professor in Anthropology, Sree Chaitanya College, Habra West Bengal State University, West Bengal, India Research Focus: Epigenetics Accomplishments: Two CVD epigenetics papers were published in PLos One and Frontiers in Genetics

2015 – 2016 Stephanie Ann Larocco, MSPH, Department of Epidemiology, University of Alabama at Birmingham. Research Focus: Cognitive genomics. Completed a project in the REGARDS dataset

Primary Mentor 2017 – Ninad Chaudhary, 3rd year PhD Student, Department of Epidemiology, University of

Alabama at Birmingham.

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Research Focus: Genomics and Epigenomics of CVD 2017 – Bre Minniefield, 2nd year PhD Student, Graduate Biomedical Sciences, University of

Alabama at Birmingham. Research Focus: Genomics and Epigenomics of CVD, Copy Number Variants, Admixture analysis Accomplishments: Positive Review on Graduate Research Supplement to R01 HL123782 (Funded 2018).

MPH Advisor 2013 – 2014 Stephanie Tison, MPH Student, Epidemiology, University of Alabama at

Birmingham 2014 – 2016 Laura Kat Purvis, MPH Student, Epidemiology, University of Alabama at

Birmingham 2014 – 2016 Ana Carr Farout, MPH Student, Epidemiology, University of Alabama at

Birmingham 2015 – 2017 Kevin Wall, MPH Student, Epidemiology, University of Alabama at Birmingham 2016 – Theodule Baptiste, MPH Student, Epidemiology, University of Alabama at

Birmingham 2016 – Emily Ness, MPH Student, Epidemiology, University of Alabama at Birmingham 2016 – Deven Patel, MPH Student, Epidemiology, University of Alabama at Birmingham 2017 – Yi Pan, MPH Student, Epidemiology, University of Alabama at Birmingham 2017 – Valerie Kenny, MPH Student, Epidemiology, University of Alabama at Birmingham

Invited Lectures 2010 “Search for genes associated with metabolic traits in special populations: progress

and pitfalls.” UAB Department of Epidemiology Seminar Series. Birmingham, AL. 2011 “Pharmacogenetics of fenofibrate response in the GOLDN study.” UAB Department

of Epidemiology Seminar Series. February 2011, Birmingham, AL. 2012 “Treatment resistant hypertension: What is it and what puts you at risk?” UAB

Department of Epidemiology Seminar Series. Oct 2012, Birmingham, AL. 2013 “Risk and prognosis in resistant hypertension.” The UAB Vascular Biology and

Hypertension Program Weekly Seminar. February, 2013, Birmingham, AL. 2013 “Genes involved in renal Na+/K+ transport modify risk for diabetes on thiazide

diuretics” UAB Gene discovery approaches workshop. UAB Heflin Center. November 2013, Birmingham AL

2014 “Disparities and outcomes in resistant hypertension.” CCHA/GRECC Scientific Seminar Series on Aging. April, 2014, Birmingham, AL.

2014 “Uric Acid Genetics in Minority Populations.” UAB Gout enrichment series. December, 2014, Birmingham, AL.

2015 “The Emerging Role of Epigenetics in Cardiovascular Disease.” UAB Department of Epidemiology Seminar Series. February 2015, Birmingham, AL.

2015 “The Emerging Role of Epigenetics in Cardiovascular Disease.” UAB Comprehensive Cardiovascular Center (CCVC) Seminar Series. February 2015, Birmingham, AL.

2015 “Epigenetics of Cardiovascular Disease.” UAB Vascular Biology & Hypertension Seminar Series. November 2015, Birmingham, AL

2017 “Cardiovascular Genomics and Pharmacogenomics” UAB Department of

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Epidemiology Seminar Series, March 2017 2018 “The emerging role of epigenetics in cardiometabolic disease” MCOR-COBRE-

MCCTR Seminar. The University of Mississippi Medical Center. April 2018. Jackson, MS

2018 “The emerging role of epigenetics in cardiometabolic disease” Department of Epidemiology and Biostatistics Seminar Series. Michigan State University. September 2018. East Lansing, MI

2018 “Next generation sequencing and CVD traits in the Hypertension Genetic Epidemiology Network Study" Vascular Biology and Hypertension Seminar Series. October 2018, Birmingham, AL

Scientific Journal Activities Review Editor

Frontiers in Pharmacogenetics and Pharmacogenomics Frontiers in Applied Genetic Epidemiology

Ad Hoc Reviewer Obesity Circulation: Cardiovascular Genetics Clinical Genetics Journal of Human Hypertension PLOS Genetics PLOS One American Journal of Clinical Nutrition

Professional Service School/University

2013 School of Public Health President’s Award for Excellence in Teaching Selection Committee, University of Alabama at Birmingham

2013 – MSPH Admission Committee, Department of Epidemiology, University of Alabama at Birmingham

2013 – 2016 Academic Programs Review Committee (APRC), Alternate Member, University of Alabama at Birmingham

2015 – PhD qualifying exam Committee, Department of Epidemiology, University of Alabama at Birmingham

2016 –2019 Graduate Curriculum Committee, School of Public Health Representative, University of Alabama at Birmingham

2017 – Responsible Conduct of Research Advisory Committee (ADCOM), School of Public Health Representative, University of Alabama at Birmingham

2017 –2019 Faculty Senate, School of Public Health Representative, University of Alabama at Birmingham

2017 –2019 Faculty Senate Research Committee, School of Public Health Representative, University of Alabama at Birmingham

2017 – High Performance Computing (HPC) Users Group, University of Alabama at Birmingham

2017 Kaul Pediatric Research Institute (KPRI) at Children’s of Alabama Pilot application review

2017 UAB Center for Clinical and Translational Science Pilot application review

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2018 UAB Obesity Health Disparities Research Center (OHDRC) Pilot Application Review

2018 UAB Faculty Development Grant Program Pilot application review 2018 UAB IRB Director Search Committee 2019 Department of Epidemiology Open Rank Faculty Search Committee

National/International

2013 – 2016 Membership and Communications Committee, Functional Genomics and Translational Biology Council, American Heart Association

2016 – 2018 Vice Chair Membership and Communications Committee, Functional Genomics and Translational Biology Council, American Heart Association

2018 – 2019 Chair Membership and Communications Committee, Genomics and Precision Medicine Council, American Heart Association

2014 Study Section, Ad hoc Member, Cardiovascular Genome Phenome Study Review Panel, American Heart Association

2016 Study Section, Ad hoc Member, Cardiovascular Genome Phenome Study Review Panel, American Heart Association

2016 – 2017 Study Section, Ad hoc Member, VA Epidemiology Research Program (EPID) review panel, ad hoc (2 X a year, Summer and Fall)

2017 – 2018 Study Section, Ad hoc Member, Million Veterans Program (MVP) (2 X a year, Summer and Fall)

2018 Study Section, Ad Hoc Member, NIH Center for Scientific Review, The Cancer, Heart, and Sleep Epidemiology Study Section –Panel B (CHSB) (Spring Review section 2/22/2018)

Journal Publications *previously published under Dickson MR and Dickson R + co-first author 1. Strange C, Dickson R, Carter C, Carpenter MJ, Holladay B, Lundquist R, Brantly ML. Genetic

testing for alpha1-antitrypsin deficiency. Genet Med. 2004;6:204-210. 2. Stoller JK, Sandhaus RA, Turino G, Dickson R, Rodgers K, Strange C. Delay in diagnosis of

alpha1-antitrypsin deficiency: a continuing problem. Chest. 2005;128:1989-94. 3. Dickson MR, Perry RT, Wiener H, Go RC. Association studies of transforming growth factor-

beta 1 and Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2005;139b:38-41. 4. Strange C, Stoller JK, Sandhaus RA, Dickson R, Turino G. Results of a survey of patients with

alpha-1 antitrypsin deficiency. Respiration. 2006;73:185-190. 5. Carpenter MJ, Strange C, Jones Y, Dickson MR, Carter C, Moseley MA, Gilbert GE. Does

genetic testing result in behavioral health change? Changes in smoking behavior following testing for alpha-1 antitrypsin deficiency. Ann Behav Med. 2007;33:22-28.

6. Dickson MR, Li J, Wiener HW, Perry RT, Blacker D, Bassett SS, Go RC. A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative. Am J Med Genet B Neuropsychiatr Genet. 2008;147b:784-792. PMC2661765.

7. Dickson MR, Carter CL, Carpenter MJ, McClure RL, McGee DA, Zapka JG, Strange C. Barriers to genetic testing among persons at risk for alpha-1 antitrypsin deficiency. Genet Test. 2008;12:501-505.

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8. Wiener HW, Klei L, Irvin MR, Perry RT, Aliyu MH, Allen TB, Bradford LD, Calkins ME, Devlin B, Edwards N, Gur RE, Gur RC, Kwentus J, Lyons PD, McEvoy JP, Nasrallah HA, Nimgaonkar VL, O'Jile J, Santos AB, Savage RM, Go RC. Linkage analysis of schizophrenia in African-American families. Schizophr Res. 2009;109:70-79. PMC2721327.

9. Irvin MR, Wiener HW, Perry RP, Savage RM, Go RC. Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder. Schizophr Res. 2009;114:50-56. PMC2753171.

10. Shrestha S, Irvin MR, Taylor KD, Wiener HW, Pajewski NM, Haritunians T, Delaney JA, Schambelan M, Polak JF, Arnett DK, Chen YD, Grunfeld C. A genome-wide association study of carotid atherosclerosis in HIV-infected men. Aids. 2010;24:583-592. PMC3072760.

11. Irvin MR, Lynch AI, Kabagambe EK, Tiwari HK, Barzilay JI, Eckfeldt JH, Boerwinkle E, Davis BR, Ford CE, Arnett DK. Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study. J Hypertens. 2010;28:2076-2083. PMC2957368.

12. Irvin MR, Kabagambe EK, Tiwari HK, Parnell LD, Straka RJ, Tsai M, Ordovas JM, Arnett DK. Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. Circ Cardiovasc Genet. 2010;3:462-467. PMC3119521.

13. Zhang Q, Irvin MR, Arnett DK, Province MA, Borecki I. A data-driven method for identifying rare variants with heterogeneous trait effects. Genet Epidemiol. 2011;35:679-685. PMC3201701.

14. Irvin MR, Shrestha S, Chen YD, Wiener HW, Haritunians T, Vaughan LK, Tiwari HK, Taylor KD, Scherzer R, Saag MS, Grunfeld C, Rotter JI, Arnett DK. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. Pharmacogenet Genomics. 2011;21:798-807. PMC3210910.

15. Irvin MR, Wineinger NE, Rice TK, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk JB, Freedman BI, Franceschini N, Broeckel U, Tiwari HK, Arnett DK. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. PLoS One. 2011;6:e24052. PMC3162025.

16. Aslibekyan S, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Shen J, Lai CQ, Ordovas JM, Arnett DK. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics. 2012;22:191-197. PMC3275691.

17. Irvin MR, Zhang Q, Kabagambe EK, Perry RT, Straka RJ, Tiwari HK, Borecki IB, Shimmin LC, Stuart C, Zhong Y, Hixson JE, Arnett DK. Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study. Pharmacogenet Genomics. 2012;22:367-372. PMC3325369.

18. Zhi D+, Irvin MR+, Gu CC, Stoddard AJ, Lorier R, Matter A, Rao DC, Srinivasasainagendra V, Tiwari HK, Turner A, Broeckel U, Arnett DK. Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy. Front Genet. 2012;3:92. PMC3361011.

19. Lynch AI, Irvin MR, Boerwinkle E, Davis BR, Vaughan LK, Ford CE, Aissani B, Eckfeldt JH, Arnett DK, Shrestha S. RYR3 gene polymorphisms and cardiovascular disease outcomes in the context of antihypertensive treatment. Pharmacogenomics J. 2013;13:330-334. PMC3435442.

20. Irvin MR, Shimbo D, Mann DM, Reynolds K, Krousel-Wood M, Limdi NA, Lackland DT, Calhoun DA, Oparil S, Muntner P. Prevalence and correlates of low medication adherence in apparent treatment-resistant hypertension. J Clin Hypertens (Greenwich). 2012;14:694-700. PMC3464920.

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21. Aslibekyan S, Goodarzi MO, Frazier-Wood AC, Yan X, Irvin MR, Kim E, Tiwari HK, Guo X, Straka RJ, Taylor KD, Tsai MY, Hopkins PN, Korenman SG, Borecki IB, Chen YD, Ordovas JM, Rotter JI, Arnett DK. Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate. PLoS One. 2012;7:e48663. PMC3485381.

22. Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Nutr Metab Cardiovasc Dis. 2013;23:987-994. PMC3578131.

23. Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G, Nguyen KD, Cooper R, Lewis CE, Leppert M, Irvin MR, Gu CC, Houston D, Buzkova P, Ritchie M, Matise TC, Le Marchand L, Hindorff LA, Crawford DC, Haiman CA, Kooperberg C. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013;9:e1003171. PMC3547789.

24. Aslibekyan S, Straka RJ, Irvin MR, Claas SA, Arnett DK. Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies. Expert Rev Cardiovasc Ther. 2013;11:355-364.

25. Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'Diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45:690-696. PMC3694490.

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26. Zhi D, Aslibekyan S, Irvin MR, Claas SA, Borecki IB, Ordovas JM, Absher DM, Arnett DK. SNPs located at CpG sites modulate genome-epigenome interaction. Epigenetics. 2013;8:802-806. PMC3883783.

27. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutierrez OM, Irvin MR, Lackland DT, Oparil S, Warnock D, Muntner P. Prevalence of apparent treatment-resistant hypertension among individuals with CKD. Clin J Am Soc Nephrol. 2013;8:1583-1590. PMC3805064.

28. Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9:e1003681. PMC3744443.

29. Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Buzkova P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, Ehret G, Gu CC, Houston D, Irvin MR, Jackson R, Kuller L, Henderson B, Cheng I, Wilkens L, Leppert M, Lewis CE, Li R, Nguyen KD, Goodloe R, Farber-Eger E, Boston J, Dilks HH, Ritchie MD, Fowke J, Pooler L, Graff M, Fernandez-Rhodes L, Cochrane B, Boerwinkle E, Kooperberg C, Matise TC, Le Marchand L, Crawford DC, Haiman CA, North KE, Peters U. Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet. 2013;93:661-671. PMC3791273.

30. Lynch AI, Irvin MR, Davis BR, Ford CE, Eckfeldt JH, Arnett DK. Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT. Int J Hypertens. 2013;2013:578578. PMC3833110.

31. Katz DH, Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Sha J, Irvin MR, Eckfeldt JH, Turner ST, Freedman BI, Arnett DK, Shah SJ. Association of low-grade albuminuria with adverse cardiac mechanics: findings from the hypertension genetic epidemiology network (HyperGEN) study. Circulation. 2014;129:42-50. PMC3888488.

32. Hidalgo B, Irvin MR, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari HK, Kabagambe EK, Ordovas JM, Arnett DK. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study. Diabetes. 2014;63:801-807. PMC3968438.

33. Shrestha S, Irvin MR, Grunfeld C, Arnett DK. HIV, inflammation, and calcium in atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:244-250. PMID24265418

34. Calhoun DA, Booth JN, 3rd, Oparil S, Irvin MR, Shimbo D, Lackland DT, Howard G, Safford MM, Muntner P. Refractory hypertension: determination of prevalence, risk factors, and comorbidities in a large, population-based cohort. Hypertension. 2014;63:451-458. PMC4141646.

35. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutierrez OM, Irvin MR, Lackland DT, Oparil S, McClellan W, Warnock DG, Muntner P. Incident ESRD and treatment-resistant hypertension:

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the reasons for geographic and racial differences in stroke (REGARDS) study. Am J Kidney Dis. 2014;63:781-788. PMC4141647.

36. Shendre A, Irvin MR, Aouizerat BE, Wiener HW, Vazquez AI, Anastos K, Lazar J, Liu C, Karim R, Limdi NA, Cohen MH, Golub ET, Zhi D, Kaplan RC, Shrestha S. RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS). Atherosclerosis. 2014;233:666-672. PMC3965606.

37. Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Rasmussen-Torvik L, Sha J, Irvin MR, Gu CC, Lewis CE, Hunt SC, Arnett DK, Shah SJ. Association of comorbidity burden with abnormal cardiac mechanics: findings from the HyperGEN study. J Am Heart Assoc. 2014;3:e000631. PMC4309045

38. Irvin MR, Aslibekyan S, Hidalgo B, Arnett DK. CPT1A: the future of heart disease detection and personalized medicine? Future Medicine Clin Lipidol. 2014;9:9-12. PMC4358228

39. Irvin MR, Zhi D, Aslibekyan S, Claas SA, Absher DM, Ordovas JM, Tiwari HK, Watkins S, Arnett DK. Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid lowering Drugs and Diet Network (GOLDN) study. PLoS One. 2014;9:e99509. PMC4048279.

40. Diaz KM, Booth JN, 3rd, Calhoun DA, Irvin MR, Howard G, Safford MM, Muntner P, Shimbo D. Healthy lifestyle factors and risk of cardiovascular events and mortality in treatment-resistant hypertension: the Reasons for Geographic and Racial Differences in Stroke study. Hypertension. 2014;64:465-471. PMC4134352.

41. Irvin MR, Zhi D, Joehanes R, Mendelson M, Aslibekyan S, Claas SA, Thibeault KS, Patel N, Day K, Jones LW, Liang L, Chen BH, Yao C, Tiwari HK, Ordovas JM, Levy D, Absher D, Arnett DK. Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study. Circulation. 2014;130:565-572. PMC4209699.

42. Irvin MR, Booth JN, 3rd, Shimbo D, Lackland DT, Oparil S, Howard G, Safford MM, Muntner P, Calhoun DA. Apparent treatment-resistant hypertension and risk for stroke, coronary heart disease, and all-cause mortality. J Am Soc Hypertens. 2014;8:405-413. PMC4120268.

43. Sorensen IF, Vazquez AI, Irvin MR, Sorensen P, Davis BR, Ford CE, Boerwinkle E, Eckfeldt JH, Arnett DK. Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study. Pharmacogenet Genomics. 2014;24:556-563. PMC4189974.

44. Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Lee DC, Patel A, Sha J, Irvin MR, Arnett DK, Shah SJ. Diastolic wall strain: a simple marker of abnormal cardiac mechanics. Cardiovasc Ultrasound. 2014;12:40. PMC4197332.

45. Liu CT, Buchkovich ML, Winkler TW, Heid IM; African Ancestry Anthropometry Genetics Consortium; GIANT Consortium, Borecki IB, Fox CS, Mohlke KL, North KE, Adrienne Cupples L. Multi-ethnic fine-mapping of 14 central adiposity loci. Hum Mol Genet. 2014;23:4738-44. PMC4119415

46. Do AN, Irvin MR, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari HK, Limdi NA, Arnett DK. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study. Front Pharmacol. 2014;5:210. PMC4165277.

47. Zhi D, Shendre A, Scherzer R, Irvin MR, Perry RT, Levy S, Arnett DK, Grunfeld C, Shrestha S. Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals. J Hum Genet. 2015;60:63-7.

48. Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C, Irvin MR, Fornage M, Hidalgo B, Lin LA, Thibeault KS, Bressler J, Tsai MY, Grove ML, Hopkins PN, Boerwinkle E, Borecki IB, Ordovas JM, Levy D, Tiwari HK, Absher DM, Arnett

Ryan Irvin CV • January 2017 • 12

DK. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity. 2015;23:1493-501. PMC4482015

49. Demerath EW, Guan W, Grove ML, Aslibekyan S, Mendelson M, Zhou YH, Hedman ÅK, Sandling JK, Li LA, Irvin MR, Zhi D, Deloukas P, Liang L, Liu C, Bressler J, Spector TD, North K, Li Y, Absher DM, Levy D, Arnett DK, Fornage M, Pankow JS, Boerwinkle E. Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet. 2015;24:4464-79. PMC4492394.

50. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA, Tsai MY, Borecki IB, Kabagambe EK, Berciano S, Ordovas JM, Absher DM, Arnett DK. Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study. Aging Cell. 2015;14:49-59. PMC4324456

51. Howard VJ, Tanner RM, Anderson A, Irvin MR, Calhoun DA, Lackland DT, Oparil S, Muntner P. Apparent treatment-resistant hypertension among individuals with history of stroke or transient ischemic attack. Am J Med. 2015;128:707-14. PMC4475646

52. Mozaffarian D, Kabagambe EK, Johnson CO, Lemaitre RN, Manichaikul A, Sun Q, Foy M, Wang L, Wiener H, Irvin MR, Rich SS, Wu H, Jensen MK, Chasman DI, Chu AY, Fornage M, Steffen L, King IB, McKnight B, Psaty BM, Djoussé L, Chen IY, Wu JH, Siscovick DS, Ridker PM, Tsai MY, Rimm EB, Hu FB, Arnett DK. Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Am J Clin Nutr. 2015;101:398-406. PMC4307209

53. Tran NT, Aslibekyan S, Tiwari HK, Zhi D, Sung YJ, Hunt SC, Rao DC, Broeckel U, Judd S, Muntner P, Kent ST, Arnett DK, Irvin MR. PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies. Frontiers in Genetics. 2015;6:136. PMC4389541

54. Gutiérrez OM, Judd SE, Irvin MR, Zhi D, Limdi N, Palmer ND, Rich SS, Sale MM, Freedman BI. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans. Nephrol Dial Transplant. 2016;31:602-8. PMC4805128

55. Das M, Irvin MR, Sha J, Aslibekyan S, Hidalgo B, Perry RT, Zhi D, Tiwari HK, Absher D, Ordovas JM, Arnett DK. Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study. Front Genet. 2015;6:304. PMC4586504

56. Aguilar FG, Selvaraj S, Martinez EE, Katz DH, Beussink L, Kim KY, Ping J, Rasmussen-Torvik L, Goyal A, Sha J, Irvin MR, Arnett DK, Shah SJ. Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study. Echocardiography. 2016;33:386-97. PMC4775325

57. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics. 2015;25:511-4. PMC4558213

58. Bis JC, Sitlani C, Irvin MR, Avery CL, Smith AV, Sun F, Evans DS, Musani SK, Li X8, Trompet S, Krijthe BP, Harris TB, Quibrera PM, Brody JA, Demissie S, Davis BR, Wiggins KL, Tranah GJ, Lange LA, Sotoodehnia N, Stott DJ, Franco OH, Launer LJ, Stürmer T, Taylor KD, Cupples LA, Eckfeldt JH, Smith NL, Liu Y, Wilson JG, Heckbert SR, Buckley BM, Ikram MA, Boerwinkle E, Chen YD, de Craen AJ, Uitterlinden AG, Rotter JI, Ford I, Hofman A, Sattar N, Slagboom PE, Westendorp RG, Gudnason V, Vasan RS, Lumley T, Cummings SR, Taylor HA Jr, Post W, Jukema JW, Stricker BH, Whitsel EA, Psaty BM, Arnett D. Drug-gene interactions of

Ryan Irvin CV • January 2017 • 13

antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium. PLoS One. 2015;10:e0140496. PMC4627813

59. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA, Tsai MY, Borecki IB, Kabagambe EK, Ordovás JM, Absher DM, Arnett DK. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Mol Nutr Food Res. 2016;60:410-9. PMC4844557

60. Das M, Sha J, Hidalgo B, Aslibekyan S, Do AN, Zhi D, Sun D, Zhang T, Li S, Chen W, Srinivasan SR, Tiwari HK, Absher D, Ordovas JM, Berenson GS, Arnett DK, Irvin MR. Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS One. 2016;11:e0145789. PMC4726462

61. NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium (ISGC). Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol. 2016;15:174-184. PMC4912948.

62. Huisingh C, Levitan EB, Irvin MR, Owsley C, McGwin G Jr. Driving with pets and motor vehicle collision involvement among older drivers: A prospective population-based study. Accid Anal Prev. 2016;88:169-74. PMC4738176

63. Do AN, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari HK, Arnett DK, Irvin MR. The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study. J Hum Hypertens. 2016;30:549-54. PMC4956602

64. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Bone. 2016;87:71-7. PMC4862915

65. Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S, Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen IY, Rotter JI, Wagner MJ, Arnett DK. A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies. Pharmacogenet Genomics. 2016;26:324-33. PMC4986826

66. Selvaraj S, Martinez EE, Aguilar FG, Kim KY, Peng J, Sha J, Irvin MR, Lewis CE, Hunt SC, Arnett DK, Shah SJ. Association of Central Adiposity with Adverse Cardiac Mechanics:Findings from the HyperGEN Study. Circ Cardiovasc Imaging. 2016;9;e004396. PMC4911824

67. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M, Delaney JA, Edwards TL, Evans DS, Evans MK, Lange LA, Leong A, Liu J, Liu Y, Nayak U, Patel SR, Porneala BC, Rasmussen-Torvik LJ, Snijder MB, Stallings SC, Tanaka T, Yanek LR, Zhao W, Becker DM, Bielak LF, Biggs ML, Bottinger EP, Bowden DW, Chen G, Correa A, Couper DJ, Crawford DC, Cushman M, Eicher JD, Fornage M, Franceschini N, Fu YP, Goodarzi MO, Gottesman O, Hara K, Harris TB, Jensen RA, Johnson AD, Jhun MA, Karter AJ, Keller MF, Kho AN, Kizer JR, Krauss RM, Langefeld CD, Li X, Liang J, Liu S, Lowe WL Jr, Mosley TH, North KE, Pacheco JA, Peyser PA, Patrick AL, Rice KM, Selvin E, Sims M, Smith JA, Tajuddin SM, Vaidya D, Wren MP, Yao J, Zhu X, Ziegler JT, Zmuda JM, Zonderman AB, Zwinderman AH; AAAG Consortium.; CARe Consortium.; COGENT-BP Consortium.; eMERGE Consortium.; MEDIA Consortium., Adeyemo A, Boerwinkle E, Ferrucci L, Hayes MG, Kardia SL, Miljkovic I, Pankow JS, Rotimi CN, Sale MM, Wagenknecht LE, Arnett DK, Chen YD, Nalls MA;

Ryan Irvin CV • January 2017 • 14

MAGIC Consortium., Province MA, Kao WH, Siscovick DS, Psaty BM, Wilson JG, Loos RJ, Dupuis J, Rich SS, Florez JC, Rotter JI, Morris AP, Meigs JB. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet. 2016;99:56-75. PMC5005440

68. Moore JX, Zakai NA, Mahalingam M, Griffin RL, Irvin MR, Safford MM, Baddley JW, Wang HE. Hemostasis Biomarkers and Risk of Sepsis: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. J Thromb Haemost. 2016;14:2169-76. PMC in process

69. Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM, Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H, Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM, Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J, Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O, Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M, Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen BH, Torstenson ES, Tracy RP, Tzoulaki I, Zakai NA, Vacchi-Suzzi C, van Duijn CM, van Rooij FJ, Cushman M, Deary IJ, Velez Edwards DR, Vergnaud AC, Wallentin L, Waterworth DM, White HD, Wilson JG, Zonderman AB, Kathiresan S, Grarup N, Esko T, Loos RJ, Lange LA, Faraday N, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016;99:8-21. PMC5005438

70. Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA,Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JB, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E, Levy D. A DNA methylation biomarker of alcohol consumption. Mol Psychiatry. 2016 Nov 15. doi: 10.1038/mp.2016.192. PMC5575985

71. Day K, Waite LL, Alonso A, Irvin MR, Zhi D, Thibeault KS, Aslibekyan S, Hidalgo B, Borecki IB, Ordovas JM, Arnett DK, Tiwari HK, Absher DM. Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects. PLoS One. 2016;11:e0165488. PMC5085095

72. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L,

Ryan Irvin CV • January 2017 • 15

DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016;9:436-447. PMC5267325.

73. Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzková P, Carlson CS, Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, Gu CC, Haessler J, Haiman CA, Henderson B, Hindorff LA, Houston D, Irvin MR, Jackson R, Kuller L, Leppert M, Lewis CE, Li R, Le Marchand L, Matise TC, Nguyen KD, Chakravarti A, Pankow JS, Pankratz N, Pooler L, Ritchie MD, Bien SA, Wassel CL, Chen YD, Taylor KD, Allison M, Rotter JI, Schreiner PJ, Schumacher F, Wilkens L, Boerwinkle E, Kooperberg C, Peters U, Buyske S, Graff M, North KE. Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. Int J Obes (Lond). 2017;41:324-331 PMC5296276.

74. Lai CQ, Wojczynski MK, Parnell LD, Hidalgo BA, Irvin MR, Aslibekyan S, Province MA, Absher DM, Arnett DK, Ordovás JM. Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge. J Lipid Res. 2016;57:2200-2207. PMC5321216.

75. Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W, Wang L, Biggs ML, Chen YD, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L, Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B, Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016;103:567-78. PMC5260796.

76. Aslibekyan S, Do AN, Xu H; Li S, Irvin MR, Zhi D, Tiwari HK, Absher DM, Shuldiner AR, Zhang T, Chen W, Tanner K, Hong C, Mitchell BD, Berenson G, Arnett DK. CPT1A methylation is associated with plasma adiponectin. Nutr Metab Cardiovasc Dis. 2017;27:225-233. PMC5330786.

77. Mendelson MM, Marioni RE, Joehanes R, Liu C, K. Hedman AK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR, Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundstrom J, Gustafsson S, Shah S, McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E, Lipovich L, Visscher PM, Wray NR, Krauss RM, Fallin D, Feinberg A, Absher DM, Fornage M, Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PloS One. 2017;14:e1002215. PMC5240936.

78. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D, Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples LA, Deloukas P, Spector TD, Sundström J, Krauss RM, Arnett DK, Deary IJ, Lind L, Levy D, Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017;10. pii: e001487. PMC5331877.

79. Shendre A, Wiener H, Irvin MR, Zhi D, Limdi NA, Overton ET, Wassel CL, Divers J, Rotter JI, Post WS, Shrestha S. Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies. Circ Cardiovasc Genet. 2017;10. pii: e001569. PMC5396391.

Ryan Irvin CV • January 2017 • 16

80. Shendre A, Irvin MR, Wiener H, Zhi D, Limdi NA, Overton ET, Shrestha S. Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study. J Am Heart Assoc. 2017;6(4). pii: e004739. PMC5532995

81. Naik RP, Irvin MR+, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR, Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp JB, Winkler CA, Cushman M. Sickle Cell Trait and the Risk of ESRD in Blacks. J Am Soc Nephrol. 2017. pii: ASN.2016101086. PMC5491293.

82. Bress AP, Irvin MR, Muntner P. Genetics of Blood Pressure: New Insights Into a Complex Trait. Am J Kidney Dis. 2017;69:723-725. PMC in process.

83. Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D; Bone Mineral Density in Childhood Study (BMDCS) Group., Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, North KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017;13:e1006719. PMC5419579.

84. Aslibekyan S, Irvin MR, Hidalgo BA, Perry RT, Jeyarajah EJ, Garcia E, Shalaurova I, Hopkins PN, Province MA, Tiwari HK, Ordovas JM, Absher DM, Arnett DK. Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). J Nutr Intermed Metab. 2017;8:1-7. PMC5400362.

85. Fernández-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y, Highland HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage M, Buzkova P, Tao R, Isasi C, Avilés-Santa L, Daviglus M, Mackey RH, Houston D, Gu CC, Ehret G, Nguyen KH, Lewis CE, Leppert M, Irvin MR, Lim U, Haiman CA, Le Marchand L, Schumacher F, Wilkens L, Lu Y, Bottinger EP, Loos RJL, Sheu WH, Guo X, Lee WJ, Hai Y, Hung YJ, Absher D, Wu IC, Taylor KD, Lee IT, Liu Y, Wang TD, Quertermous T, Juang JJ, Rotter JI, Assimes T, Hsiung CA, Chen YI, Prentice R, Kuller LH, Manson JE, Kooperberg C, Smokowski P, Robinson WR, Gordon-Larsen P, Li R, Hindorff L, Buyske S, Matise TC, Peters U, North KE. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum Genet. 2017;136:771-800. PMC5485655.

86. Owolabi M, Sarfo F, Howard VJ, Irvin MR, Gebregziabher M, Akinyemi R, Bennett A, Armstrong K, Tiwari HK, Akpalu A, Wahab KW, Owolabi L, Fawale B, Komolafe M, Obiako R, Adebayo P, Manly JM, Ogbole G, Melikam E, Laryea R, Saulson R, Jenkins C, Arnett DK, Lackland DT, Ovbiagele B, Howard G; SIREN-REGARDS Collaboration (Stroke Investigative Research and Educational Network–Reasons for Geographic and Racial Differences in Stroke).

Ryan Irvin CV • January 2017 • 17

Stroke in Indigenous Africans, African Americans, and European Americans: Interplay of Racial and Geographic Factors. Stroke. 2017;48:1169-1175. PMC5404953.

87. Katz DH, Deo RC, Aguilar FG, Selvaraj S, Martinez EE, Beussink-Nelson L, Kim KA, Peng J, Irvin MR, Tiwari H, Rao DC, Arnett DK, Shah SJ. Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res. J Cardiovasc Transl Res. 2017 Jun;10(3):275-284. PMC in process.

88. Sayols-Baixeras S, Irvin MR, Arnett DK, Elosua R, Aslibekyan SW. Epigenetics of Lipid Phenotypes. Curr Cardiovasc Risk Rep. 2016;10. pii: 31. PMC5421987.

89. Vemulapalli S, Deng L, Patel MR, Kilgore ML, Jones WS, Curtis LH, Irvin MR, Svetkey LP, Shimbo D, Calhoun DA, Muntner P. National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension. Am Heart J. 2017;186:29-39. PMC in process.

90. Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ, Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M, Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M, Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP, Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A, Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST, Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehnia N, Stricker BH, Surendran P, Thom S, Töglhofer AM, Uitterlinden AG, Wachter R, Völzke H, Ziegler A, Münzel T, März W, Cappola TP, Hirschhorn JN, Mitchell GF, Smith NL, Fox ER, Dueker ND, Jaddoe VWV, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks AA, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty BM, Blankenberg S, Larson MG, Felix SB, Franco OH, Zeller T, Vasan RS, Dörr M. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest. 2017;127:1798-1812. PMC5409098.

91. Liu N, Irvin MR, Zhi D, Patki A, Beasley TM, Nickerson DA, Hill CE, Chen J, Kimmel SE, Limdi NA. Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array. Pharmacogenomics. 2017 Jul;18(11):1059-1073. PMC5619051

92. Tanner RM, Shimbo D, Irvin MR, Spruill TM, Bromfield SG, Seals SR, Young BA, Muntner P. Chronic kidney disease and incident apparent treatment-resistant hypertension among blacks: Data from the Jackson Heart Study. J Clin Hypertens (Greenwich). 2017 Nov;19(11):1117-1124. PMC5693725

93. Akinyemi R, Arnett DK, Tiwari HK, Ovbiagele B, Sarfo F, Srinivasasainagendra V, Irvin MR, Adeoye A, Perry RT, Akpalu A, Jenkins C, Owolabi L, Obiako R, Wahab K, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Akpa O, Melikam S, Saulson R, Kalaria R, Ogunniyi A, Owolabi M; SIREN Investigators. Interleukin-6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men. J Neurol Sci. 2017 Aug 15;379:229-235. PMC5546618

94. Selvaraj S, Djoussé L, Aguilar FG, Martinez EE, Polsinelli VB, Irvin MR, Arnett DK, Shah SJ. Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the HyperGEN Study. J Am Coll Cardiol. 2017 Aug 8;70(6):715-724. PMC5571737

Ryan Irvin CV • January 2017 • 18

95. Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P. PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites. Circ Cardiovasc Genet. 2017 Aug;10(4):e001632. PMC in process

96. Raffield LM, Zakai NA, Duan Q, Laurie C, Smith JD, Irvin MR, Doyle MF, Naik RP, Song C, Manichaikul AW, Liu Y, Durda P, Rotter JI, Jenny NS, Rich SS, Wilson JG, Johnson AD, Correa A, Li Y, Nickerson DA, Rice K, Lange EM, Cushman M, Lange LA, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis TOPMed Working Group*. D-Dimer in African Americans: Whole Genome Sequence Analysis and Relationship to Cardiovascular Disease Risk in the Jackson Heart Study. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2220-2227. PMC5658238

97. Yanik MV, Irvin MR, Beasley TM3, Jacobson PA, Julian BA, Limdi NA. Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage. Pharmacotherapy. 2017 Nov;37(11):1366-1373. PMC5681429

98. Mefford MT, Rosenson RS, Cushman M, Farkouh ME, McClure LA, Wadley VG, Irvin MR, Bittner VA, Safford MM, Somaratne R, Monda KL, Muntner P, Levitan EB. PCSK9 Variants, LDL-Cholesterol, and Neurocognitive Impairment: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Circulation. 2017 Nov 16. pii: CIRCULATIONAHA.117.029785. PMC in process

99. Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, Guan W, Mosley TH Jr, Bressler J, Morrison AC, Liu C, Mendelson MM, Uitterlinden AG, van Meurs JB; Franco OH, Zhang G, Li Y, Stewart JD, Bis JC, Psaty BM, Chen YI, Kardia SLR, Zhao W, Turner ST, Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz JD, Vokonas PS, Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI, Palmas W, Liu Y, Paus T, Horvath S, O'Connell JR, Guo X, Pausova Z, Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. Am J Hum Genet. 2017 Dec 7;101(6):888-902. doi: 10.1016/j.ajhg.2017.09.028.

100. Owolabi M, Peprah E, Xu H, Akinyemi R, Tiwari HK, Irvin MR, Wahab KW, Arnett DK, Ovbiagele B. Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities. J Neurol Sci. 2017 Nov 15;382:18-28. doi: 10.1016/j.jns.2017.09.021.

101. Huisingh C, Levitan EB, Irvin MR, MacLennan P, Wadley V, Owsley C. Visual Sensory and Visual-Cognitive Function and Rate of Crash and Near-Crash Involvement Among Older Drivers Using Naturalistic Driving Data. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2959-2967.

102. Yusuf N, Hidalgo B, Irvin MR, Sha J, Zhi D, Tiwari HK, Absher D, Arnett DK, Aslibekyan S. An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Pharmacogenomics. 2017 Sep;18(14):1333-1341. doi: 10.2217/pgs-2017-0037.

103. Shendre A, Wiener HW, Irvin MR, Aouizerat BE, Overton ET, Lazar J, Liu C, Hodis HN, Limdi NA, Weber KM, Gange SJ, Zhi D, Floris-Moore MA, Ofotokun I, Qi Q, Hanna DB, Kaplan RC, Shrestha S. Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS). PLoS One. 2017 Dec 4;12(12):e0188725.

Ryan Irvin CV • January 2017 • 19

104. Do AN, Zhao W, Srinivasasainagendra V, Aslibekyan S, Tiwari HK, Limdi N, Shah SJ, Zhi D, Broeckel U, Gu CC, Rao DC, Schwander K, Smith JA, Kardia S, Arnett DK , Irvin MR. Whole Exome Analyses to Examine the Impact of Rare Variants on Left Ventricular Traits in African American Participants from the HyperGEN and GENOA Studies. J Hypertens Manag 2017, 3:025 DOI: 10.23937/2474-3690/1510025

105. Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. 2017 Oct 24;89(17):1829-1839. doi: 10.1212/WNL.0000000000004560. Epub 2017 Sep 27. PubMed PMID: 28954878; PubMed Central PMCID: PMC5664302.

106. Irvin MR, Booth JN, Sims M, Bress AP, Abdalla M, Shimbo D, Calhoun D, Muntner P. The association of nocturnal hypertension and non-dipping blood pressure with treatment resistant hypertension: The Jackson Heart Study. The Journal of Clinical Hypertension. 2018 Mar;20(3):438-446 PMC5907922

107. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Jr., Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jimenez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmae K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Bjorkegren JLM, Codoni V, Civelek M, Smith NL, Tregouet DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT, Jr., Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Jr., Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA,

Ryan Irvin CV • January 2017 • 20

Ingelsson E, Irvin MR, Jian X, Jimenez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmae K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dorr M, Engstrom G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, Minegishi N, Montaner J, Morris AP, Muino E, Muller-Nurasyid M, Norrving B, Ogishima S, Parati EA, Peddareddygari LR, Pedersen NL, Pera J, Perola M, Pezzini A, Pileggi S, Rabionet R, Riba-Llena I, Ribases M, Romero JR, Roquer J, Rudd AG, Sarin AP, Sarju R, Sarnowski C, Sasaki M, Satizabal CL, Satoh M, Sattar N, Sawada N, Sibolt G, Sigurdsson A, Smith A, Sobue K, Soriano-Tarraga C, Stanne T, Stine OC, Stott DJ, Strauch K, Takai T, Tanaka H, Tanno K, Teumer A, Tomppo L, Torres-Aguila NP, Touze E, Tsugane S, Uitterlinden AG, Valdimarsson EM, van der Lee SJ, Volzke H, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT, Jr., Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Consortium AF, Cohorts for H, Aging Research in Genomic Epidemiology C, International Genomics of Blood Pressure C, Consortium I, Starnet, BioBank Japan Cooperative Hospital G, Consortium C, Consortium E-C, Consortium EP-I, International Stroke Genetics C, Consortium M, Neurology Working Group of the CC, Network NSG, Study UKYLD, Consortium M and Consortium M. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524-537.doi: 10.1038/s41588-018-0058-3

108. Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort. J Lipid Res. 2018 Apr;59(4):722-729. doi: 10.1194/jlr.P080333.

109. Booth JN III, Li M, Shimbo D, Hess R, Irvin MR, Kittles R, Wilson JG, Jorde L, Cheung A, Lange L, Lange E, Yano T, Muntner P, Bress AP. West African ancestry and nocturnal blood pressure in African Americans: the Jackson Heart Study. Am J Hypertens. 2018 May 7;31(6):706-714. doi: 10.1093/ajh/hpy038.

110. Akinyemiju T, Do AN, Patki A, Aslibekyan S, Zhi D, Hidalgo B, Tiwari HK, Absher D, Geng X, Arnett DK, Irvin MR. Epigenome-wide association study of metabolic syndrome in African-American adults. Clin Epigenetics. 2018 Apr 10;10:49. doi: 10.1186/s13148-018-0483-2

111. Akinyemi R, Tiwari HK, Arnett DK, Ovbiagele B, Irvin MR, Wahab K, Sarfo F, Srinivasasainagendra V, Adeoye A, Perry RT, Akpalu A, Jenkins C, Arulogun O, Gebregziabher M, Owolabi L, Obiako R, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Onoja A, Akinyemi J, Ogbole G, Melikam S, Saulson

Ryan Irvin CV • January 2017 • 21

R, Owolabi M; SIREN Investigators. APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke. Acta Neurol Scand. 2018 Jan;137(1):133-141. PMC5716854

112. Irvin MR, Aslibekyan S, Do A, Zhi D, Hidalgo B, Claas SA, Srinivasasainagendra V, Horvath S, Tiwari HK, Absher DM, Arnett DK. Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study. Clin Epigenetics. 2018 Apr 18;10:56. doi: 10.1186/s13148-018-0481-4.

113. Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA. APOL1 nephropathy risk variants and incident cardiovascular disease events in community-dwelling Black adults. Circ Genom Precis Med. 2018 Jun;11(6):e002098. doi: 10.1161/CIRCGEN.117.002098

114. de Oliveira Otto MC, Lemaitre RN, Sun Q, King IB, Wu JHY, Manichaikul A, Rich SS, Tsai MY, Chen YD, Fornage M, Weihua G, Aslibekyan S, Irvin MR, Kabagambe EK, Arnett DK, Jensen MK, McKnight B, Psaty BM, Steffen LM, Smith CE, Risérus U, Lind L, Hu FB, Rimm EB, Siscovick DS, Mozaffarian D. Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: results from the CHARGE Consortium. PLoS One. 2018 May 8;13(5):e0196951. doi: 10.1371/journal.pone.0196951

115. Liu C, Marioni RE, Hedman AK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kuhnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA, Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JBJ, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E and Levy D. A DNA methylation biomarker of alcohol consumption. Mol Psychiatry. 2018;23:422-433.

116. Mitchell KA, Moore JX, Rosenson RS, Irvin R, Guirgis FW, Shapiro N, Safford M and Wang HE. PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. PLoS One. 2019;14:e0210808.

117. Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK and Zhi D. An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort. J Lipid Res. 2018;59:722-729.

118. Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, Lim U, Lu Y, Gross M, Fornage M, Yoneyama S, Isasi CR, Buzkova P, Daviglus M, Lin DY, Tao R, Goodloe R, Bush WS, Farber-Eger E, Boston J, Dilks HH, Ehret G, Gu CC, Lewis CE, Nguyen KH, Cooper R, Leppert M, Irvin MR, Bottinger EP, Wilkens LR, Haiman CA, Park L, Monroe KR, Cheng I, Stram DO, Carlson CS, Jackson R, Kuller L, Houston D, Kooperberg C, Buyske S, Hindorff LA, Crawford DC, Loos RJF, Le Marchand L, Matise TC, North KE and Peters U. Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond). 2018;42:384-390

119. Zekavat SM, Ruotsalainen S, Handsaker RE, Alver M, Bloom J, Poterba T, Seed C, Ernst J, Chaffin M, Engreitz J, Peloso GM, Manichaikul A, Yang C, Ryan KA, Fu M, Johnson WC, Tsai M, Budoff M, Vasan RS, Cupples LA, Rotter JI, Rich SS, Post W, Mitchell BD, Correa A, Metspalu A, Wilson JG, Salomaa V, Kellis M, Daly MJ, Neale BM, McCarroll S, Surakka I,

Ryan Irvin CV • January 2017 • 22

Esko T, Ganna A, Ripatti S, Kathiresan S, Natarajan P and NHLBI TOPMed Lipids Working Group. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018;9:2606.

120. Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkanen N, Franzen O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Volzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney L, Lind L, Raffield LM, Launer LJ, Holdt LM, Dorr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hagg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimaki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y, Consortium M, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikainen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Volker U, Gudnason V, Hingorani AD, Bjorkegren JLM, Casas JP and O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018;9:5141.

121. Natarajan P, Peloso GM, Zekavat SM, Montasser M, Ganna A, Chaffin M, Khera AV, Zhou W, Bloom JM, Engreitz JM, Ernst J, O'Connell JR, Ruotsalainen SE, Alver M, Manichaikul A, Johnson WC, Perry JA, Poterba T, Seed C, Surakka IL, Esko T, Ripatti S, Salomaa V, Correa A, Vasan RS, Kellis M, Neale BM, Lander ES, Abecasis G, Mitchell B, Rich SS, Wilson JG, Cupples LA, Rotter JI, Willer CJ, Kathiresan S and NHLBI TOPMed Lipids Working Group. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018;9:3391.

122. Hyacinth HI, Carty CL, Seals SR, Irvin MR, Naik RP, Burke GL, Zakai NA, Wilson JG, Franceschini N, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Longstreth WT, Jr., Egede L, Lackland DT, Taylor H, Manson JE, Howard V, Allison M, Gee BE, Correa A, Safford MM, Arnett DK, Howard G, Reiner AP and Cushman M. Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis. JAMA Neurol. 2018;75:802-807.

123. Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto A, Hsu FC, Jackson AU, Kahonen M, Kasturiratne A, Kuhnel B, Leander K, Lee WJ, Lin KH, an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stancakova A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B,

Ryan Irvin CV • January 2017 • 23

Caizheng Y, Campbell A, Canouil M, Chakravarti A, Group CNW, Chauhan G, Christensen K, Cocca M, Consortium CO-K, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dorr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H, Consortium G, Gigante B, Graff M, Gu CC, Gu D, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lifelines Cohort S, Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Magi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH, Jr., Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renstrom F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimaki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC and Chasman DI. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018;102:375-400.

124. Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S;

Ryan Irvin CV • January 2017 • 24

Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print] PubMed PMID: 30651383; PubMed Central PMCID: PMC6369905.

125. Fan S, Kind T, Cajka T, Hazen SL, Tang WHW, Kaddurah-Daouk R, Irvin MR, Arnett DK, Barupal DK, Fiehn O. Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data. Anal Chem. 2019 Mar 5;91(5):3590-3596. doi: 10.1021/acs.analchem.8b05592. Epub 2019 Feb 19. PubMed PMID: 30758187.

126. Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids. Front Genet. 2019 Feb 26;10:158. doi: 10.3389/fgene.2019.00158. eCollection 2019. PubMed PMID: 30863429; PubMed Central PMCID: PMC6399202.

127. He KY, Li X, Kelly TN, Liang J, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bress AP, Chang YC, Chen YI, de Vries PS, Fox ER, Franceschini N, Furniss A, Gao Y, Guo X, Haessler J, Hwang SJ, Irvin MR, Kalyani RR, Liu CT, Liu C, Martin LW, Montasser ME, Muntner PM, Mwasongwe S, Palmas W, Reiner AP, Shimbo D, Smith JA, Snively BM, Yanek LR, Boerwinkle E, Correa A, Cupples LA, He J, Kardia SLR, Kooperberg C, Mathias RA, Mitchell BD, Psaty BM, Vasan RS, Rao DC, Rich SS, Rotter JI, Wilson JG, NHLBI Trans-Omics for Precision Medicine Consortium TOPMed Blood Pressure Working Group, Chakravarti A, Morrison AC, Levy D, Arnett DK, Redline S and Zhu X. Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data. Hum Genet. 2019;138:199-210.

128. Huisingh C, Owsley C, Wadley VG, Levitan EB, Irvin MR, MacLennan P and McGwin G, Jr. General cognitive impairment as a risk factor for motor vehicle collision involvement: a prospective population-based study. Geriatrics (Basel). 2018;3(1).pii:11.

129. Huisingh C, Owsley C, Levitan EB, Irvin MR, MacLennan P and McGwin G. Distracted Driving and Risk of Crash or Near-Crash Involvement Among Older Drivers Using Naturalistic Driving Data With a Case-Crossover Study Design. J Gerontol A Biol Sci Med Sci. 2019;74:550-555.

130. Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium. Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. Neurology. 2019 Feb 26;92(9):e944-e950. doi: 10.1212/WNL.0000000000007001. Epub 2019 Jan 25. PubMed PMID: 30804065; PubMed Central PMCID: PMC6404465.

131. Luo Y, Mao C, Yang Y, Wang F, Ahmad FS, Arnett D, Irvin MR and Shah SJ. Integrating hypertension phenotype and genotype with hybrid non-negative matrix factorization. Bioinformatics. 2019 Feb 7. doi: 10.1093/bioinformatics/btz049. [Epub ahead of print] PubMed PMID: 30753340.

132. Khan SS, Kim KA, Peng J, Aguilar FG, Selvaraj S, Martinez EE, Baldridge AS, Sha J, Irvin MR, Broeckel U, Arnett DK, Rasmussen-Torvik LJ and Shah SJ. Clinical correlates and heritability of cardiac mechanics: The HyperGEN study. Int J Cardiol. 2019;274:208-213.

133. Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig

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FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpelainen TO, Kardia SLR, Jorgensen ME, Jorgensen T, Sorensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI and North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019;104:112-138.

134. Irvin MR, Sitlani CM, Noordam R, Avery CL, Bis JC, Floyd JS, Li J, Limdi NA, Srinivasasainagendra V, Stewart J, de Mutsert R, Mook-Kanamori DO, Lipovich L, Kleinbrink EL, Smith A, Bartz TM, Whitsel EA, Uitterlinden AG, Wiggins KL, Wilson JG, Zhi D, Stricker BH, Rotter JI, Arnett DK, Psaty BM and Lange LA. Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry. Pharmacogenomics J. 2019;19:97-108.

135. Zhao X, Geng X, Srinivasasainagendra V, Chaudhary N, Judd S, Wadley V, Gutiérrez OM, Wang H, Lange EM, Lange LA, Woo D, Unverzagt FW, Safford M, Cushman M, Limdi N, Quarells R, Arnett DK, Irvin MR, Zhi D. A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study. BMC Med Genomics. 2019 Jan 31;12(Suppl 1):26. doi: 10.1186/s12920-018-0462-7. PubMed PMID: 30704471; PubMed Central PMCID: PMC6357353.

Book Chapters 1. Padilla MA, Irvin MR, Tiwari HK. Gene-environment Interactions: Gene-environment

interactions in human traits in Nriagu J (ed) Encyclopedia on Environmental Health, Elsevier Science, 2011.

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2. Irvin MR. Genetics of complex traits in Shah SJ, Arnett DK (eds) Cardiovascular Genetics and Genomics in Clinical Practice, Demos Medical, 2014.

Abstracts and Posters 1. Dickson MR, Go R CP, Wiener H, Blacker D, Bassett SS. A genomic scan for age at onset

of Alzheimer’s disease from the NIMH Genetic Initiative. Poster Presentation at Annual International Genetic Epidemiology Society Meeting. November 2006, Tampa Bay, FL.

2. Dickson MR, Wiener HW, Perry RP, Go R CP. Genetic risk factors for type 2 diabetes with pharmacologic intervention in patients with schizophrenia and schizoaffective disorder. Poster Presentation at Genome-wide Association: Analyze This! August 2008, Bethesda, MD.

3. Irvin MR, Lynch AI, Kabagambe EK, Tiwari HK , Barzilay JI, Eckfeldt J, Boerwinkle E, Davis BR, Ford CE, Arnett DK. Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study. Poster Presentation, American Heart Association Cardiovascular Disease Epidemiology and Prevention Conference. March 3-5th 2010, San Francisco, CA.

4. Irvin MR, Wineinger N, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk JB, Freedman B, Franceschini N, Tiwari HK, Arnett DK. Genome wide detection of allele specific copy number variation associated with diabetes related traits in African Americans from the HyperGEN Study. Poster Presentation, HudsonAlpha Spring Symposium. March 30th 2010, Hunstville, AL.

5. Irvin MR, Kabagambe EK, Zhang Q, Sha J, Tiwari HK, Borecki IB, Province MA, Shimmin LC, Hixson JE, and Arnett DK. Rare PPARa variants and extreme response to fenofibrate in the GOLDN Study. Poster Presentation, Evolution of Next-Generation Sequencing Data Management Workshop. September 27-29th 2010, Providence, RI.

6. Irvin MR, Kabagambe EK, Zhang Q, Sha J, Tiwari HK, Borecki IB, Province MA, Shimmin LC, Hixson JE, and Arnett DK.. Rare PPARa variants and extreme response to fenofibrate in the GOLDN Study. Poster Presentation at the 51th annual American Heart Association Cardiovascular Disease Epidemiology and Prevention Conference. March 23-25th 2011, Atlanta, GA.

7. Irvin MR, Wood AC, Vaughn LK, Kabagambe EK, Sha J, Tiwari HK, Borecki IB, Ordovas JM, Arnett DK. Genetics of Insulin Response to Fenofibrate in the GOLDN Study. Poster Presentation, AHA Scientific Sessions. Nov 12-15 2011, Orlando, FL.

8. Arnett DK, Borecki IB, Irvin MR, Tiwari HK, Straka RJ, Ordovas JM. Genome-Wide Association Study of Lipid Response to Fenofibrate Treatment in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) Study. Nutrition, Physical Activity and Metabolism / Cardiovascular Disease Epidemiology and Prevention Scientific Sessions, March 2012, San Diego, CA.

9. Aguilar FG, Selvaraj S, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L, Sha J, Irvin MR, Arnett DK, Shah DJ. Serum Uric Acid is an Independent Risk Factor for Subclinical Cardiac Dysfunction: A Speckle- Tracking Analysis of the HyperGEN Study. Abstract Oral Session, AHA Scientific Sessions. Nov 7 2012. Los Angeles, CA.

10. Shah SJ, Aguilar FG, Selvaraj S, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L, Sha J, Irvin MR, Budinger S, Mutlu GM, Arnett DK. Adverse Effects of Obesity, Hyperglycemia, and Insulin Resistance on Cardiac Mechanics. Abstract Oral Session, American Heart Association Scientific Sessions. Nov 7 2012, Los Angeles, CA.

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11. Selvaraj S, Aguilar FG, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L, Sha J, Irvin MR, Arnett DK, Shah SJ. Diastolic Wall Strain: A Simple Marker of Abnormal Cardiac Mechanics. Poster Presentation, American Heart Association Scientific Sessions. Nov 5 2012, Los Angeles, CA.

12. Irvin MR, Booth JN, Shimbo D, Lackland DT, Oparil S, Howard G, Safford M, Muntner P, Calhoun DA. Apparent Treatment Resistant Hypertension and Risk for Stroke, Coronary Heart Disease and All-cause Mortality. Poster Presentation, American Heart Association EPI/NPAM March 2013 New Orleans, LA.

13. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutiérrez OM, Irvin MR, Lackland DT, Oparil S, Warnock D, Muntner, P. Prevalence of aTRH among individuals with CKD: results from the REGARDS study. Moderated Poster Presentation, American Heart Association EPI/NPAM March 2013 New Orleans, LA.

14. Katz DH, Selvaraj S, Aguilar F, Martinez E, Beussink L, Kim K, Peng J, Sha J, Irvin MR, Freedman B, Eckfeldt J, Arnett DK, Shah S. Association of Albuminuria with Adverse Cardiac Mechanics: Findings from the HyperGEN Study. Poster Presentation, American College of Cardiology March 2013, San Francisco, CA.

15. Aslibekyan S, Irvin MR, Sha J, Zhi D, Thibeault KS, Tsai M, Hopkins P, Borecki IB, Ordovas JM, Absher D, Arnett DK. CPT1A Methylation is a Novel Epigenetic Marker of Cardiovascular Risk. Oral Presentation, AHA Emerging Science Series, June 19, 2013, Dallas, TX.

16. Howard VJ, Tanner RM, Irvin MR, Calhoun DA, Anderson A, Lackland DT, Oparil S, Muntner P. Prevalence and Predictors of Apparent Treatment-Resistant Hypertension among Individuals with a History of Physician-Diagnosed Stroke or TIA. Oral Presentation, American Heart Association/American Stroke Association International Stroke Conference, Feb 2014, San Diego, CA.

17. Diaz KM, Booth JN, Calhoun DA, Irvin MR, Howard G, Safford MM, Muntner P, Shimbo D. Association of healthy lifestyle factors with all-cause mortality and incident cardiovascular events among individuals with apparent treatment resistant hypertension: the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study. Moderated Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco, CA.

18. Bromfield S, Shimbo D, Diaz K, Booth J, Calhoun D, Irvin MR, Krousel-Wood M, Redmond N, Oparil S, Muntner P. The associations between apparent treatment resistant hypertension and low mental and physical functioning, depressive symptoms, and stress. Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco, CA.

19. Aslibekyan S, Hidalgo B, Irvin MR, Sha J, Tiwari HK, Zhi D, Ordovas JM, Absher D, Arnett DK. Epigenome-wide study of erythrocyte fatty acids in the Genetics of Lipid Lowering Drugs and Diet Network. Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco, CA.

20. Hidalgo B, Irvin MR, Aslibekyan S, Sha J, Zhi D, Ordovas JM, Absher D, Tiwari HK, Arnett DK. Epigenome-wide association study of lipid and inflammatory marker response fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network Study. Moderated Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco, CA.

21. Irvin, MR; Zhi, D; Limdi, NA; Sitlani, CM; Floyd, JS; Avery, CL; Musani, SK; Smith, AV; Noordam, R; Arnett, DK on behalf of the CHARGE Pharmacogenetics Working Group. Genome-Wide Meta-analysis of SNP-by-Thiazide diuretic and SNP-by-ACEI/ARB effect on

Ryan Irvin CV • January 2017 • 28

serum potassium in cohorts of European and African Ancestry in CHARGE. Winter CHARGE Conference, November 2014, Washington DC.

22. Kent ST, Rosenson RS, Avery CL, Correa A, Cummings SR, Cupples LA, Cushman M, , Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Emily B Levitan EB, Li X, Liu Y, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P. PCSK9 Loss-of-function Variants, Low-density Lipoprotein Cholesterol, And Risk Of Coronary Heart Disease And Stroke: Data From The REGARDS Study And CHARGE Consortium. Oral presentation. American Heart Association Scientific Sessions November 2015, Orlando, FL.

23. Vemulapalli S, Deng L, Patel MR, Kilgore ML, Jones WS, Curtis LH, Irvin MR, Svetkey LP; Shimbo D, Calhoun DA, Muntner P. National Patterns in Intensity and Frequency of Outpatient Care for Apparent Treatment Resistant Hypertension. Poster presentation. American Heart Association Scientific Sessions November 2015, Orlando, FL.

24. Irvin MR, Zhi D, Limdi N, Sitlani C, Floyd F, Avery C, Whitsel E, Lange L, Smith A, Noordam R, Arnett DK. Genome-Wide Meta-analysis of SNP-by-Thiazide diuretic and SNP-by-ACEI/ARB effect on serum potassium in cohorts of European and African Ancestry in CHARGE. Moderated Poster presentation. American Heart Association Epi Lifestyle March 2016, Phoenix, AZ.

25. Do AN, Irvin MR, Zhi D, Tiwari HK, Aslibekyan S, Zhao W, Smith J, Rao DC, Claas SA, Broeckel U, Arnett DK. Epigenetic determinants of left ventricular traits and functions in hypertensive African Americans. CVGPS special poster session. American Heart Association Scientific Sessions November 2016, New Orleans LA.

26. Irvin MR, Hidalgo B, Zhi D, Aslibekyan S, Tiwari HK, Absher D, Arnett DK. Epigenetic Age Acceleration and Postprandial Lipemia in the Genetics of Lipid Lowering Drugs and Diet Network Study. Poster. EPI/Lifestyle 2017 Scientific Sessions, March 2017, Portland, OR.

27. Gutiérrez OM+, Irvin MR+, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Nelson GW, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA. APOL1 nephropathy risk variants and incident cardiovascular disease events in community-dwelling Black adults ASN Kidney Week 2017 Annual Meeting, October 31 - November 5 in New Orleans, LA.

28. Jones AC, Irvin MR, Chaudhary NS, Howard VJ, Howard H, Judd SE. Walkability as a Predictor of Incident Hypertension in a National Cohort Study. UASOM Medical Student Research Day, Tuesday, August 7, 2018, Birmingham AL. 1st Place Prize Poster

29. Jones AC, Irvin MR, Chaudhary NS, Howard VJ, Howard H, Judd SE. Walkability as a Predictor of Incident Hypertension in a National Cohort Study. EPI/Lifestyle 2019 Scientific Sessions, Houston TX.

30. Colantonio LC, Saag KG, Singh JA, Chen L, Reynolds RJ, Gaffo A, Plante TB, Curtis JR, Bridges SL, Levitan EB, Chaudhary NS, Howard G, Safford MM, Muntner P, Irvin MR. Gout and risk for incident heart failure, coronary heart disease and stroke: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. EPI/Lifestyle 2019 Scientific Sessions, Houston TX.

External Research Support

Ongoing

Ryan Irvin CV • January 2017 • 29

Genetic Underpinnings of Cardiorenal Risk in Africans and African Americans NIH/NHLBI R01HL13666 (PIs: Irvin and Lange) African Americans are overburdened by hypertension and related comorbidities, representing a major area of racial health disparity, with African Americans having higher risk and worse outcomes. The proposed work will identify novel genetic risk factors for various cardiorenal measures in African Americans and Africans. The results may help better understand the potential ancestral genetic etiology and lead to improved disease diagnosis as well as cardiovascular disease prevention. Role: Co-PI (4/01/17 – 03/31/2021)

Genomic Background of Blood Pressure Response to Thiazide Diuretic in African Americans.

NIH/NHLBI 1R01HLHL123782-01 (PI: Irvin) Hypertension (unhealthy high blood pressure) tends to begin earlier in life in African Americans and clinical consequences (for example, cardiovascular disease) occur more rapidly. Thiazide diuretics are the most common treatment for hypertension in this race group, yet some persons do not respond to the medicine or have adverse metabolic side effects. The proposed work will identify novel genetic risk factors for response and potentially harmful metabolic side effects. Role: Principal Investigator (09/15/2016 – 05/31/2021)

Genomics of lipidomic phenotypes in a postprandial intervention dietary study 15SDG25760020-American Heart Association Scientist Development Grant-National Center This project will add deeper lipid phenotyping to the well-characterized Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study using stored plasma samples. We will then evaluate the association of the new phenotypes with existing genetic and epigenetic markers to reveal novel loci underlying lipid metabolism. Role: Principal Investigator (07/01/2015 – 06/30/2019)

HyperGEN: Genetics of Left Ventricular (LV) Hypertrophy NIH/NHLBI 2R01HL055673-16 (PI: Arnett) To further understand the genetic architecture of LV hypertrophy and related traits. Role: Subcontract PI (07/15/2013 – 04/30/2017 NCE)

Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics NIH/NHLBI 2R01HL107577-05 (PI: Shah) The overall goal of the proposed studies is to leverage a unique ability to digitize and speckle-track archived echoes from epidemiologic studies with the goal of further understanding determinants, trajectories, and consequences of abnormal cardiac mechanics. Role: Subcontract PI (07/05/2016 – 4/30/2020)

Metabolic predictors of stroke in REGARDS NIH/NINDS 1R01NS099209-01 (PI: Kimberly) There are geographic and racial disparities in the burden of stroke across the United States. In this proposal, we will apply novel metabolite profiling techniques developed by our group to test the hypothesis that metabolomics will illuminate stroke-associated markers and unravel racial differences in that risk. These efforts have the potential to improve our ability to identify individuals at risk for stroke and improve the understanding of underlying mechanisms of disease. Role: Subcontract PI (12/01/2016 – 11/30/2021)

Genomewide Association: Triglyceride Response to Fenofibrate Therapy and Dietary Fat NIH/NHLBI 5R01HL091357-04 (PI: Arnett)

Ryan Irvin CV • January 2017 • 30

This study aims to identify genetic variants that influence fat and cholesterol’s response to diet and drugs. Role: Subcontract PI (04/01/2015 – 03/31/2019)

Trace Mineral Levels, The Trajectory of Cognitive Decline and Telomere Attrition NIH/NIA 1R01AG056111 (PI: He) The overall objective of this project is to examine a few trace mineral concentrations measured in urine or serum in relation to the trajectory of cognitive decline, as well as telomere length and telomere attrition. The proposed study will help to identify at-risk Americans for cognitive decline and/or the consequences of aging. For nutritious minerals, information generated from this study will be useful for future interventions related to healthy aging; and for the toxic ones at low-to-moderate exposure level, knowledge gained will serve as a scientific foundation for remediation and prevention strategies to improve cognitive health or slow down the consequences of aging. Role: PI of Subcontract (09/01/2017-08/31/2022)

Identification of the role of HDL function in human cardiovascular disease through proteomics and genetics

NIH/NHLBI 1R01HL136373-01 (PI: Pamir) This study will use available genomic data with the REGARDS study to determine genetic variants responsible for dysfunctional HDL associated with human cardiovascular disease and/or stroke events. Role- PI of Subcontract (11/01/2017-08/31/2022)

VCID and Stroke in a Bi-racial National Cohort (REGARDS) NIH/NINDS 2 U01 NS041588 (PIs: Manly and Howard) This is a longitudinal cohort study of > 30,000 black and white participants over the age of 45: 21% from the “buckle” of the stroke belt, 35% from the rest of the stroke belt area, and 44% from the remainder of the 40 contiguous states. The aims of the current grant are to: 1) advance the understanding of disparities in the rate of cognitive decline and the development of clinically defined cognitive impairment, 2) continue to advance the understanding of disparities in stroke risk, with particular emphasis on stroke in the elderly, and 3) assess biomarkers contributing to the disparities in the development of hypertension and diabetes.

Role: Co-Investigator (09/01/01 – 01/31/23) Transitions to Family Caregiving and the impact on Caregivers’ Health

NIH/NINDS R01AG050609-01 (PI: Roth) The proposed investigation will make major contributions to the research literature on the health effects of caregiving. We propose to identify and study a large group of individuals who have transitioned from being non-caregivers into an informal family caregiving role at some point during their participation in a large, ongoing, national epidemiologic study. Role- Co-Investigator (04/01/2016-03/31/2021)

Completed

HyperGEN: Genetics of Left Ventricular (LV) Hypertrophy – TOPMed Supplement NIH/NHLBI 3R01HL055673-18S1 (PI: Arnett) To further understand the genetic architecture of LV hypertrophy and related traits using whole-genome sequencing. Role: Co-Investigator (08/14/2015 – 04/30/2017 NCE)

Ryan Irvin CV • January 2017 • 31

Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate NHLBI 1R01HL104135-01 (PI: Arnett) Research focuses on genetic and epigenetic response to lipid-lowering treatment with fenofibrate in the Genetics of Lipid Lowering and Diet Network Study (GOLDN). Role: Co-Investigator (08/15/2010 – 05/31/2014)

Stroke Investigative Research & Educational Network (SIREN) NIH/NHGRI 1U54HG007479-01 (PI: Owolabi) As a key aspect of the Stroke Investigative Research and Education Network (SIREN), the overall goals of the Systematic Investigation of Blacks with Stroke (SIBS) Genomics project are to evaluate the premier genetic risk factors for stroke in black Africans, and through training and mentoring build sustainable cardiovascular genomics expertise/capacity in Sub-Saharan Africa. Role: Co-Investigator (08/01/2015 – 07/31/2017)

Epigenetic Determinants of Left Ventricular and Function in Hypertensive African Americans

American Heart Association CVGPS Pathway (PI: Arnett) Left ventricular hypertrophy (a thickening of heart walls that can reduce the heart's ability to pump effectively) is common in African Americans, and it contributes more to the risk of cardiovascular death in African Americans than it does in other race groups. This project is designed to determine which non-coding genetic factors (that is, epigenetic factors) may play a role in the development of left ventricular hypertrophy in African Americans. Role: Subcontract PI (02/01/2015 – 01/31/2017)

Prospective Meta-Analyses of Drug-Gene Interactions: CHARGE GWAS Consortium NIH/NHLBI 1R01HL103612-02 (PI: Psaty) The benefits of modern drug therapies can be maximized by avoiding some medications in patients who are genetically susceptible to adverse reactions or by selecting other medications for patients who are genetically likely to benefit. This broad-based discovery effort may help to illuminate biologic mechanisms, affect how some drugs are prescribed, or identify novel targets for new therapies. Role: Subcontract PI (08/10/2011 – 05/31/2015)

UAB CFAR-Lipidomic profiling in HIV patients newly initiating antiretroviral treatments NIH/NIAID Administrative Supplement to 5P30AI027767-27 (PI: Saag) Cardiovascular disease (CVD) is the second leading cause of death among people with HIV. Changes in lipids after starting retroviral treatment may contribute to that statistic. This study will investigate changes in small-molecule lipids and link those changes to clinical lipids and measures of CVD risk aiming to better understand mechanisms underlying CVD in HIV+ individuals. Role: Principal on Supplement (06/30/2015 – 05/31/2016 NCE)

Genetic Variants in Calcium Channel and Binding Proteins Underlying cIMT in HIV NIH/NHLBI 1R56HL125061(PI: Shrestha) The major objective of this study is to conduct deep-sequencing and examine genetic variants in 9 genes encoding Ca2+ channels (RYR1, RYR2, RYR3, IP3R) and other related proteins (GADD153, CALM1, CALM2, CALM3, CAMKII) in HIV patients that exhibit extreme (high/low) carotid intima-media thickness measurements. Role: Co-Investigator (09/01/2015 – 08/31/2016)

Training Grant NIH/NINDS T32NS054584 (PI: Cutter)

Ryan Irvin CV • January 2017 • 32

Research focus is on risk factors for cardiovascular disease in disadvantaged populations including African Americans. Role: Post-doc (7/01/07 – 6/30/13)

GenHAT – Genetics of Hypertension Associated Treatments NIH/NHLBI R01 HL063082-05 (PI: Arnett) To evaluate whether hypertension candidate genotypes can predict therapeutic response to antihypertensive therapy. Role: Post-Doc (09/01/99 – 05/31/10)

Internal Pilot Research Funding Ongoing

Epigenetic biomarkers of preeclampsia risk among mothers with chronic hypertension UAB Center for Clinical and Translational Sciences Multidisciplinary Network Pilot Program Conduct genome-wide CpG methylation analysis to identify epigenetic variation contributing to preeclampsia in mothers with chronic hypertension. Role: Principal Investigator (4/1/2016 – 3/31/2017)

Completed Epigenetic risk factors for treatment resistant hypertension in African Americans

UAB Minority Health Research Center Pilot and Feasibility Program 2014 Conduct genome-wide CpG methylation analysis to identify epigenetic variation contributing to treatment resistant hypertension (TRH) in 50 TRH cases and 50 age-matched normotensive controls using UAB clinic based samples. Role: Principal Investigator (7/1/2014 – 6/31/2015)

Genes involved in renal Na+/K+ transport modify risk for diabetes on thiazide diuretics UAB Diabetes and Research Training Center Pilot and Feasibility Program 2012 Candidate gene study of risk factors for increased fasting glucose levels due to thiazide diuretic treatment for hypertension among African Americans participating in the Genetics of Hypertension Associated Treatment Study. Role: Principal Investigator (6/1/2012 – 5/31/2013) *Supported funding NIH/NHLBI 1R01HLHL123782-01 (PI: Irvin)